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Conserved domains on  [gi|1721979160|ref|XP_030234623|]
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NFU1 iron-sulfur cluster scaffold homolog, mitochondrial-like [Gadus morhua]

Protein Classification

NifU family protein( domain architecture ID 10658661)

NifU family protein may play a role in the biogenesis of Fe/S proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nfu_N smart00932
Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU ...
 51-138 2.22e-39

Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein. Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters.


:

Pssm-ID: 214919  Cd Length: 88  Bit Score: 131.49  E-value: 2.22e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721979160   51 VQTQDTPNPRSLKFLPGKPVLGSGTLDFPSPSSAECSS-LARDLFEIEGVKSVFFGPDFITVTKmDDDVEWTDIKRYSLD 129
Cdd:smart00932   1 IQTEPTPNPNTLKFLPGEFVLPGGSAEFKSADEAAEASpLAQKLFEIPGVKSVFFGPDFITVTK-YPDVDWEDLKPEVLS 79


                   ....*....
gi 1721979160  130 AIVKFFESG 138
Cdd:smart00932  80 VIMEHFESG 88
NifU COG0694
Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, ...
 57-230 1.82e-36

Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440458 [Multi-domain]  Cd Length: 176  Bit Score: 127.08  E-value: 1.82e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721979160  57 PNPRSLKFLPGKPVLGSGTLDFPSPSSAECSSLARDLFEIEGVKSVFFGPDFITVTKMDDDVEWTDIKRYSLDAIVKFFE 136
Cdd:COG0694     1 AQAAALKLLPEEPGGELIRGEVAAPGAPAAAALLLAEAPEVEEDDDVVVVAAVFVAVTDELSGPLLELAIIDAILAAAGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721979160 137 SGTPITTGAVN--NESSFSEDDDEVVAIIKELLDNRIRPTVQEDGGDIIYKGFEDGIVKVKLVGSCTGCPSSTVTLKNGI 214
Cdd:COG0694    81 QLTLAAPDAAVaeVLSFHALTDAELEERIEEVLDEEIRPALASDGGDIELVDVEDGVVYVRLGGACSGCPSSTMTLKNGI 160

                         170
                  ....*....|....*.
gi 1721979160 215 QNMMQFYIPEVVAVEQ 230
Cdd:COG0694   161 ERALKERVPEVKEVEA 176
 
Name Accession Description Interval E-value
Nfu_N smart00932
Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU ...
 51-138 2.22e-39

Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein. Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters.


Pssm-ID: 214919  Cd Length: 88  Bit Score: 131.49  E-value: 2.22e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721979160   51 VQTQDTPNPRSLKFLPGKPVLGSGTLDFPSPSSAECSS-LARDLFEIEGVKSVFFGPDFITVTKmDDDVEWTDIKRYSLD 129
Cdd:smart00932   1 IQTEPTPNPNTLKFLPGEFVLPGGSAEFKSADEAAEASpLAQKLFEIPGVKSVFFGPDFITVTK-YPDVDWEDLKPEVLS 79


                   ....*....
gi 1721979160  130 AIVKFFESG 138
Cdd:smart00932  80 VIMEHFESG 88
NifU COG0694
Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, ...
 57-230 1.82e-36

Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440458 [Multi-domain]  Cd Length: 176  Bit Score: 127.08  E-value: 1.82e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721979160  57 PNPRSLKFLPGKPVLGSGTLDFPSPSSAECSSLARDLFEIEGVKSVFFGPDFITVTKMDDDVEWTDIKRYSLDAIVKFFE 136
Cdd:COG0694     1 AQAAALKLLPEEPGGELIRGEVAAPGAPAAAALLLAEAPEVEEDDDVVVVAAVFVAVTDELSGPLLELAIIDAILAAAGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721979160 137 SGTPITTGAVN--NESSFSEDDDEVVAIIKELLDNRIRPTVQEDGGDIIYKGFEDGIVKVKLVGSCTGCPSSTVTLKNGI 214
Cdd:COG0694    81 QLTLAAPDAAVaeVLSFHALTDAELEERIEEVLDEEIRPALASDGGDIELVDVEDGVVYVRLGGACSGCPSSTMTLKNGI 160

                         170
                  ....*....|....*.
gi 1721979160 215 QNMMQFYIPEVVAVEQ 230
Cdd:COG0694   161 ERALKERVPEVKEVEA 176
Nfu_N pfam08712
Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU ...
 51-124 1.04e-35

Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein. Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters.


Pssm-ID: 462574  Cd Length: 81  Bit Score: 121.81  E-value: 1.04e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1721979160  51 VQTQDTPNPRSLKFLPGKPVL-GSGTLDFPSPSSAECSSLARDLFEIEGVKSVFFGPDFITVTKmDDDVEWTDIK 124
Cdd:pfam08712   1 IQTEPTPNPNALKFIPGKPLLpEGGTAEFKSAEEAKASPLAQKLFAIPGVKSVFIGPDFITVTK-DDDVDWEDLK 74
NifU pfam01106
NifU-like domain; This is an alignment of the carboxy-terminal domain. This is the only common ...
 163-229 3.37e-32

NifU-like domain; This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown.


Pssm-ID: 460066 [Multi-domain]  Cd Length: 67  Bit Score: 112.53  E-value: 3.37e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1721979160 163 IKELLDNRIRPTVQEDGGDIIYKGFEDGIVKVKLVGSCTGCPSSTVTLKNGIQNMMQFYIPEVVAVE 229
Cdd:pfam01106   1 IEEVLEEEIRPALQADGGDIELVDVDDGVVYVRLQGACSGCPSSTMTLKNGIEQALKEKVPEVKRVE 67
 
Name Accession Description Interval E-value
Nfu_N smart00932
Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU ...
 51-138 2.22e-39

Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein. Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters.


Pssm-ID: 214919  Cd Length: 88  Bit Score: 131.49  E-value: 2.22e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721979160   51 VQTQDTPNPRSLKFLPGKPVLGSGTLDFPSPSSAECSS-LARDLFEIEGVKSVFFGPDFITVTKmDDDVEWTDIKRYSLD 129
Cdd:smart00932   1 IQTEPTPNPNTLKFLPGEFVLPGGSAEFKSADEAAEASpLAQKLFEIPGVKSVFFGPDFITVTK-YPDVDWEDLKPEVLS 79


                   ....*....
gi 1721979160  130 AIVKFFESG 138
Cdd:smart00932  80 VIMEHFESG 88
NifU COG0694
Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, ...
 57-230 1.82e-36

Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440458 [Multi-domain]  Cd Length: 176  Bit Score: 127.08  E-value: 1.82e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721979160  57 PNPRSLKFLPGKPVLGSGTLDFPSPSSAECSSLARDLFEIEGVKSVFFGPDFITVTKMDDDVEWTDIKRYSLDAIVKFFE 136
Cdd:COG0694     1 AQAAALKLLPEEPGGELIRGEVAAPGAPAAAALLLAEAPEVEEDDDVVVVAAVFVAVTDELSGPLLELAIIDAILAAAGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721979160 137 SGTPITTGAVN--NESSFSEDDDEVVAIIKELLDNRIRPTVQEDGGDIIYKGFEDGIVKVKLVGSCTGCPSSTVTLKNGI 214
Cdd:COG0694    81 QLTLAAPDAAVaeVLSFHALTDAELEERIEEVLDEEIRPALASDGGDIELVDVEDGVVYVRLGGACSGCPSSTMTLKNGI 160

                         170
                  ....*....|....*.
gi 1721979160 215 QNMMQFYIPEVVAVEQ 230
Cdd:COG0694   161 ERALKERVPEVKEVEA 176
Nfu_N pfam08712
Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU ...
 51-124 1.04e-35

Scaffold protein Nfu/NifU N terminal; This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein. Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters.


Pssm-ID: 462574  Cd Length: 81  Bit Score: 121.81  E-value: 1.04e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1721979160  51 VQTQDTPNPRSLKFLPGKPVL-GSGTLDFPSPSSAECSSLARDLFEIEGVKSVFFGPDFITVTKmDDDVEWTDIK 124
Cdd:pfam08712   1 IQTEPTPNPNALKFIPGKPLLpEGGTAEFKSAEEAKASPLAQKLFAIPGVKSVFIGPDFITVTK-DDDVDWEDLK 74
NifU pfam01106
NifU-like domain; This is an alignment of the carboxy-terminal domain. This is the only common ...
 163-229 3.37e-32

NifU-like domain; This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown.


Pssm-ID: 460066 [Multi-domain]  Cd Length: 67  Bit Score: 112.53  E-value: 3.37e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1721979160 163 IKELLDNRIRPTVQEDGGDIIYKGFEDGIVKVKLVGSCTGCPSSTVTLKNGIQNMMQFYIPEVVAVE 229
Cdd:pfam01106   1 IEEVLEEEIRPALQADGGDIELVDVDDGVVYVRLQGACSGCPSSTMTLKNGIEQALKEKVPEVKRVE 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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