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Conserved domains on  [gi|1721952473|ref|XP_030229874|]
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asporin [Gadus morhua]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
115-323 7.13e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 7.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 115 GENAFKGIHKLYALFLINNKITKIhPKAFKNMDHLKLLYLSYNLLTEIPANLPR--NILELRFHGNRINTIqKEAFKGLR 192
Cdd:COG4886   105 GNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDL-PEELGNLT 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 193 NLNVLEMSANPLANSGIALGafdGMSSLyigmaeakltavpkdlpasiTELSLDYNKISKVEiEDFIRYGELQKLGLSFN 272
Cdd:COG4886   183 NLKELDLSNNQITDLPEPLG---NLTNL--------------------EELDLSGNQLTDLP-EPLANLTNLETLDLSNN 238

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1721952473 273 QIKSVEngSLALIPKIREICLDNNKLKKVPaELGSLRNLQVVYLHANKISS 323
Cdd:COG4886   239 QLTDLP--ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTD 286
LRRNT smart00013
Leucine rich repeat N-terminal domain;
72-101 4.90e-09

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 51.16  E-value: 4.90e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 1721952473   72 CPAGCQCWPRVVQCSDQGLIAIPGKIPEDT 101
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
115-323 7.13e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 7.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 115 GENAFKGIHKLYALFLINNKITKIhPKAFKNMDHLKLLYLSYNLLTEIPANLPR--NILELRFHGNRINTIqKEAFKGLR 192
Cdd:COG4886   105 GNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDL-PEELGNLT 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 193 NLNVLEMSANPLANSGIALGafdGMSSLyigmaeakltavpkdlpasiTELSLDYNKISKVEiEDFIRYGELQKLGLSFN 272
Cdd:COG4886   183 NLKELDLSNNQITDLPEPLG---NLTNL--------------------EELDLSGNQLTDLP-EPLANLTNLETLDLSNN 238

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1721952473 273 QIKSVEngSLALIPKIREICLDNNKLKKVPaELGSLRNLQVVYLHANKISS 323
Cdd:COG4886   239 QLTDLP--ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTD 286
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
89-315 6.78e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.95  E-value: 6.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473  89 GLIAIPGKIPEDTVMIDLQNNDITDVGENafkgihkLYAlflinnkitkihpkafknmdHLKLLYLSYNLLTEIPANLPR 168
Cdd:PRK15370  189 GLTTIPACIPEQITTLILDNNELKSLPEN-------LQG--------------------NIKTLYANSNQLTSIPATLPD 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 169 NILELRFHGNRINTIQKEAFKGLRNLNVlemSANPLanSGIALGAFDGMSslYIGMAEAKLTAVPKDLPASITELSLDYN 248
Cdd:PRK15370  242 TIQEMELSINRITELPERLPSALQSLDL---FHNKI--SCLPENLPEELR--YLSVYDNSIRTLPAHLPSGITHLNVQSN 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 249 KISKVEIE-----DFIRYGE-------------LQKLGLSFNQIKSVENgslALIPKIREICLDNNKLKKVPAEL-GSLR 309
Cdd:PRK15370  315 SLTALPETlppglKTLEAGEnaltslpaslppeLQVLDVSKNQITVLPE---TLPPTITTLDVSRNALTNLPENLpAALQ 391


                  ....*.
gi 1721952473 310 NLQVVY 315
Cdd:PRK15370  392 IMQASR 397
LRR_8 pfam13855
Leucine rich repeat;
104-159 1.75e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 1.75e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1721952473 104 IDLQNNDITDVGENAFKGIHKLYALFLINNKITKIHPKAFKNMDHLKLLYLSYNLL 159
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
72-101 4.90e-09

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 51.16  E-value: 4.90e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 1721952473   72 CPAGCQCWPRVVQCSDQGLIAIPGKIPEDT 101
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 238-324 4.54e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 4.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 238 ASITELSLDYNKISKveIEDFIRYGELQKLGLSFNQIKSVENgsLALIPKIREICLDNNKLKKVPaELGSLRNLQVVYLH 317
Cdd:cd21340     2 KRITHLYLNDKNITK--IDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLG 76


                  ....*..
gi 1721952473 318 ANKISSV 324
Cdd:cd21340    77 GNRISVV 83
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 72-98 4.63e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.61  E-value: 4.63e-06
                          10        20
                  ....*....|....*....|....*..
gi 1721952473  72 CPAGCQCWPRVVQCSDQGLIAIPGKIP 98
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
115-323 7.13e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 7.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 115 GENAFKGIHKLYALFLINNKITKIhPKAFKNMDHLKLLYLSYNLLTEIPANLPR--NILELRFHGNRINTIqKEAFKGLR 192
Cdd:COG4886   105 GNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDL-PEELGNLT 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 193 NLNVLEMSANPLANSGIALGafdGMSSLyigmaeakltavpkdlpasiTELSLDYNKISKVEiEDFIRYGELQKLGLSFN 272
Cdd:COG4886   183 NLKELDLSNNQITDLPEPLG---NLTNL--------------------EELDLSGNQLTDLP-EPLANLTNLETLDLSNN 238

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1721952473 273 QIKSVEngSLALIPKIREICLDNNKLKKVPaELGSLRNLQVVYLHANKISS 323
Cdd:COG4886   239 QLTDLP--ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-301 2.07e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 2.07e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473  81 RVVQCSDQGLIAIPGKIPEDT--VMIDLQNNDITDVGEnAFKGIHKLYALFLINNKITKIhPKAFKNMDHLKLLYLSYNL 158
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQ 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 159 LTEIPANL--PRNILELRFHGNRINTIqKEAFKGLRNLNVLEMSANPLANsgiaLGAFDGMSSL-YIGMAEAKLTAVPKD 235
Cdd:COG4886   194 ITDLPEPLgnLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTD----LPELGNLTNLeELDLSNNQLTDLPPL 268

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1721952473 236 LP-ASITELSLDYNKISKVEIEDFIRYGELQKLGLSFNQIKSVENGSLALIPKIREICLDNNKLKKV 301
Cdd:COG4886   269 ANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
104-324 2.49e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 2.49e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 104 IDLQNNDITDVGENAFKGIHKLYALFLINNKitkihpkAFKNMDHLKLLYLSYNLLTEIPANLPR--NILELRFHGNRIN 181
Cdd:COG4886    77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLT 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 182 TIQkEAFKGLRNLNVLEMSANPLansgialgafdgmsslyigmaeakltavpKDLPASITELSldynkiskveiedfiry 261
Cdd:COG4886   150 DLP-EPLGNLTNLKSLDLSNNQL-----------------------------TDLPEELGNLT----------------- 182

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1721952473 262 gELQKLGLSFNQIKSVENgSLALIPKIREICLDNNKLKKVPAELGSLRNLQVVYLHANKISSV 324
Cdd:COG4886   183 -NLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
103-323 1.63e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 1.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 103 MIDLQNNDITDVGENAFKGIHKLYALFLINNKITKIHPKAFKNMDHLKLLYLSYNLLTEIPANLPRNILELRFHGNRINT 182
Cdd:COG4886     7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 183 IQKEAFKGLRNLNVLEMSANPlansgiALGAFDGMSSLYIGmaEAKLTAVPKDLPA--SITELSLDYNKISkvEIEDFIR 260
Cdd:COG4886    87 LGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLS--GNQLTDLPEELANltNLKELDLSNNQLT--DLPEPLG 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1721952473 261 Y-GELQKLGLSFNQIKSVENgSLALIPKIREICLDNNKLKKVPAELGSLRNLQVVYLHANKISS 323
Cdd:COG4886   157 NlTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTD 219
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
104-259 5.73e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.50  E-value: 5.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 104 IDLQNNDITDVGEnAFKGIHKLYALFLINNKITKIhPKAFKNMDHLKLLYLSYNLLTEIP--ANLPrNILELRFHGNRIN 181
Cdd:COG4886   187 LDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPelGNLT-NLEELDLSNNQLT 263

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1721952473 182 TIQKEAfkGLRNLNVLEMSANPLANSGIA-LGAFDGMSSLYIGMAEAKLTAVPKDLPASITELSLDYNKISKVEIEDFI 259
Cdd:COG4886   264 DLPPLA--NLTNLKTLDLSNNQLTDLKLKeLELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
89-315 6.78e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.95  E-value: 6.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473  89 GLIAIPGKIPEDTVMIDLQNNDITDVGENafkgihkLYAlflinnkitkihpkafknmdHLKLLYLSYNLLTEIPANLPR 168
Cdd:PRK15370  189 GLTTIPACIPEQITTLILDNNELKSLPEN-------LQG--------------------NIKTLYANSNQLTSIPATLPD 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 169 NILELRFHGNRINTIQKEAFKGLRNLNVlemSANPLanSGIALGAFDGMSslYIGMAEAKLTAVPKDLPASITELSLDYN 248
Cdd:PRK15370  242 TIQEMELSINRITELPERLPSALQSLDL---FHNKI--SCLPENLPEELR--YLSVYDNSIRTLPAHLPSGITHLNVQSN 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 249 KISKVEIE-----DFIRYGE-------------LQKLGLSFNQIKSVENgslALIPKIREICLDNNKLKKVPAEL-GSLR 309
Cdd:PRK15370  315 SLTALPETlppglKTLEAGEnaltslpaslppeLQVLDVSKNQITVLPE---TLPPTITTLDVSRNALTNLPENLpAALQ 391


                  ....*.
gi 1721952473 310 NLQVVY 315
Cdd:PRK15370  392 IMQASR 397
LRR_8 pfam13855
Leucine rich repeat;
104-159 1.75e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 1.75e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1721952473 104 IDLQNNDITDVGENAFKGIHKLYALFLINNKITKIHPKAFKNMDHLKLLYLSYNLL 159
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
124-204 3.13e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 3.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 124 KLYALFLINNKITKIHPKAFKNMDHLKLLYLSYNLLTEIPANlprnilelrfhgnrintiqkeAFKGLRNLNVLEMSANP 203
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPG---------------------AFSGLPSLRYLDLSGNR 60


                  .
gi 1721952473 204 L 204
Cdd:pfam13855  61 L 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
72-101 4.90e-09

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 51.16  E-value: 4.90e-09
                           10        20        30
                   ....*....|....*....|....*....|
gi 1721952473   72 CPAGCQCWPRVVQCSDQGLIAIPGKIPEDT 101
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 95-322 1.87e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.31  E-value: 1.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473  95 GKIPEdtVMIDLQNNDITDVGENAFKG--------IHKLYALFLINNKITKIHPKAFKNMDHLKLLYLSYNLLT-EIPAN 165
Cdd:PLN00113  298 GEIPE--LVIQLQNLEILHLFSNNFTGkipvaltsLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTgEIPEG 375

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 166 L--PRNILELRFHGNRINTIQKEAFKGLRNLNVLEMSANPLanSGIALGAFDGMSSLYI-----GMAEAKLTAVPKDLPa 238
Cdd:PLN00113  376 LcsSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSF--SGELPSEFTKLPLVYFldisnNNLQGRINSRKWDMP- 452

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 239 SITELSLDYNKISKvEIEDFIRYGELQKLGLSFNQIKSVENGSLALIPKIREICLDNNKLK-KVPAELGSLRNLQVVYLH 317
Cdd:PLN00113  453 SLQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLS 531


                  ....*
gi 1721952473 318 ANKIS 322
Cdd:PLN00113  532 HNQLS 536
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 93-322 1.02e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473  93 IPGKIPEDtvMIDLQNNDITDVGENAFKG--------IHKLYALFLINNKITKIHPKAFKNMDHLKLLYLSYNLLT-EIP 163
Cdd:PLN00113  152 LSGEIPND--IGSFSSLKVLDLGGNVLVGkipnsltnLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIP 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 164 ANLprnilelrfhgnrintiqkeafKGLRNLNVLEMSANPLanSGIALGAFDGMSSL-YIGMAEAKLTAvpkDLPASITE 242
Cdd:PLN00113  230 YEI----------------------GGLTSLNHLDLVYNNL--TGPIPSSLGNLKNLqYLFLYQNKLSG---PIPPSIFS 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 243 L----SLDY--NKISKVEIEDFIRYGELQKLGLSFNQIKSVENGSLALIPKIREICLDNNKLK-KVPAELGSLRNLQVVY 315
Cdd:PLN00113  283 LqkliSLDLsdNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLD 362


                  ....*..
gi 1721952473 316 LHANKIS 322
Cdd:PLN00113  363 LSTNNLT 369
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 238-324 4.54e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 4.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 238 ASITELSLDYNKISKveIEDFIRYGELQKLGLSFNQIKSVENgsLALIPKIREICLDNNKLKKVPaELGSLRNLQVVYLH 317
Cdd:cd21340     2 KRITHLYLNDKNITK--IDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLG 76


                  ....*..
gi 1721952473 318 ANKISSV 324
Cdd:cd21340    77 GNRISVV 83
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 72-98 4.63e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.61  E-value: 4.63e-06
                          10        20
                  ....*....|....*....|....*..
gi 1721952473  72 CPAGCQCWPRVVQCSDQGLIAIPGKIP 98
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 106-302 1.67e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 106 LQNNDITDVGEnaFKGIHKLYALFLINNKITKIhpKAFKNMDHLKLLYLSYNLLTEIP--ANLPRniLE-LRFHGNRINT 182
Cdd:cd21340     9 LNDKNITKIDN--LSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEnlENLVN--LKkLYLGGNRISV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 183 IqkEAFKGLRNLNVLEMSANPLAnSGIALgAFDGMSSLYIGmaeakltavpkdlpASITELSLDYNKISkvEIEDFIRYG 262
Cdd:cd21340    83 V--EGLENLTNLEELHIENQRLP-PGEKL-TFDPRSLAALS--------------NSLRVLNISGNNID--SLEPLAPLR 142

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1721952473 263 ELQKLGLSFNQIKSVEN--GSLALIPKIREICLDNNKLKKVP 302
Cdd:cd21340   143 NLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
239-298 2.69e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 2.69e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 239 SITELSLDYNKISKVEIEDFIRYGELQKLGLSFNQIKSVENGSLALIPKIREICLDNNKL 298
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 104-289 3.14e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.55  E-value: 3.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 104 IDLQNNDITDVGENAF----KGIHKLYALFLINNKITKIH----PKAFKNMDHLKLLYLSYNLLTE-----IPANLPRN- 169
Cdd:COG5238   241 LDLSNNQIGDEGVIALaealKNNTTVETLYLSGNQIGAEGaialAKALQGNTTLTSLDLSVNRIGDegaiaLAEGLQGNk 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 170 -ILELRFHGNRINTIQK----EAFKGLRNLNVLEMSANPLANSGIalgafdgmsslyIGMAEAkltavPKDLPaSITELS 244
Cdd:COG5238   321 tLHTLNLAYNGIGAQGAialaKALQENTTLHSLDLSDNQIGDEGA------------IALAKY-----LEGNT-TLRELN 382

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1721952473 245 LDYNKISKVEIE---DFIRYGELQKLGLSFNQIKSVENGSL-ALIPKIR 289
Cdd:COG5238   383 LGKNNIGKQGAEaliDALQTNRLHTLILDGNLIGAEAQQRLeQLLERIK 431
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
233-325 5.54e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 5.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 233 PKDLPASITELSLDYNKISKVEIEDFIRYGELQKLGLSFNQiksvengSLALIPKIREICLDNNKLKKVPAELGSLRNLQ 312
Cdd:COG4886    67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANLTNLK 139

                          90
                  ....*....|...
gi 1721952473 313 VVYLHANKISSVG 325
Cdd:COG4886   140 ELDLSNNQLTDLP 152
LRR_8 pfam13855
Leucine rich repeat;
168-220 6.40e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 6.40e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1721952473 168 RNILELRFHGNRINTIQKEAFKGLRNLNVLEMSANPLanSGIALGAFDGMSSL 220
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSL 51
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 108-195 7.70e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 42.15  E-value: 7.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 108 NNDITDVGENAFKG--IHKLYalflINNKITKIHPKAFKNMDHLKLLYLSYNlLTEIPANLPRN--ILELRFHGNrINTI 183
Cdd:pfam13306  42 PSSLTSIGSYAFYNcsLTSIT----IPSSLTSIGEYAFSNCSNLKSITLPSN-LTSIGSYAFSNcsLKSITIPSS-VTTI 115

                          90
                  ....*....|..
gi 1721952473 184 QKEAFKGLRNLN 195
Cdd:pfam13306 116 GSYAFSNCSNLK 127
LRR_8 pfam13855
Leucine rich repeat;
263-321 4.57e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 4.57e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 263 ELQKLGLSFNQIKSVENGSLALIPKIREICLDNNKLKKV-PAELGSLRNLQVVYLHANKI 321
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 92-178 5.18e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 5.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473  92 AIP---GKIPEdTVMIDLQNNDITDVGENAFKGIHKLYALFLINNKITKIHPKAFKNMDHLKLLYLSYNLLT-EIPANLP 167
Cdd:PLN00113  490 AVPrklGSLSE-LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLG 568

                          90
                  ....*....|....*...
gi 1721952473 168 R-------NILELRFHGN 178
Cdd:PLN00113  569 NveslvqvNISHNHLHGS 586
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 223-335 7.01e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 7.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 223 GMAEAKLTAVPKDLPASITELSLDYNKISKVEIED----FIRYGELQKLGLSFNQIKsvENGSLALIPKIREIC------ 292
Cdd:cd00116   122 DRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEAlakaLRANRDLKELNLANNGIG--DAGIRALAEGLKANCnlevld 199

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1721952473 293 LDNNKL-----KKVPAELGSLRNLQVVYLHANKISSVGVNDFCPVSLG 335
Cdd:cd00116   200 LNNNGLtdegaSALAETLASLKSLEVLNLGDNNLTDAGAAALASALLS 247
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 80-275 1.74e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473  80 PRVVQCSDQGLIAIPGkipedTVMIDLQNNDITDVGENAFKGIHKLYAL---FLINNKI----TKIHPKAFKNMDH-LKL 151
Cdd:cd00116    67 PRGLQSLLQGLTKGCG-----LQELDLSDNALGPDGCGVLESLLRSSSLqelKLNNNGLgdrgLRLLAKGLKDLPPaLEK 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 152 LYLSYNLLT---------EIPANlpRNILELRFHGNRI-------------------------NTIQK-------EAFKG 190
Cdd:cd00116   142 LVLGRNRLEgascealakALRAN--RDLKELNLANNGIgdagiralaeglkancnlevldlnnNGLTDegasalaETLAS 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473 191 LRNLNVLEMSANPLANSGIAlgAF-DGMSSLYIgmaeakltavpkdlpaSITELSLDYNKISKVEIEDFIRY----GELQ 265
Cdd:cd00116   220 LKSLEVLNLGDNNLTDAGAA--ALaSALLSPNI----------------SLLTLSLSCNDITDDGAKDLAEVlaekESLL 281

                         250
                  ....*....|
gi 1721952473 266 KLGLSFNQIK 275
Cdd:cd00116   282 ELDLRGNKFG 291
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 102-202 2.91e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.86  E-value: 2.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721952473  102 VMIDLQNNDITDVGENAFKGIH-----KLYALFLINNKITKIH-PKAFKNMDH-LKLLYLSYNLLTEIPANL-PRNILEL 173
Cdd:PLN03210   537 ITLDIDEIDELHIHENAFKGMRnllflKFYTKKWDQKKEVRWHlPEGFDYLPPkLRLLRWDKYPLRCMPSNFrPENLVKL 616

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1721952473  174 RFHGNRINTIQK--EAFKGLRNLNvLEMSAN 202
Cdd:PLN03210   617 QMQGSKLEKLWDgvHSLTGLRNID-LRGSKN 646
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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