BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1721879200 176 GHVVGWYQYAQRIGDAPLQDSCLRYLSWNLSSVLQSAEWTSVSADLLLTLLRRSDLVVQSELELYDGLEAW 246
Cdd:cd18493     3 NHAVSWLQYAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKW 73

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1721879200 176 GHVVGWYQYAQRIGDAPLQDSCLRYLSWNLSSVLQSAEWTSVSADLLLTLLRRSDLVVQSELELYDGLEAW 246
Cdd:cd18493     3 NHAVSWLQYAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKW 73

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721879200 178 VVGWYQYAQRIGDAPLQDSCLRYLSWNLSSVLQSAEWTSVSADLLLTLLRRSDLVVQSELELYDGLEAWAARNRPGGPT- 256
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKh 80

                          90       100
                  ....*....|....*....|...
gi 1721879200 257 AERALEAIRYGMIPPQKLFHLQK 279
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721879200  58 MENLMALGNASDVSLRVQTlnteevKVLPAHSLVLSLQSDVFRDLLL--ARNGSALVLSETVECAAVFDKFLRYLYCGDI 135
Cdd:pfam00651   1 LNELREQGELCDVTLVVGD------KEFRAHKAVLAACSPYFKALFSgqESESSVSEITLDDVSPEDFEALLEFMYTGKL 74

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1721879200 136 sVRLDQAIPLHQLATKYRVEGLQLGLTQFMSQHL 169
Cdd:pfam00651  75 -ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1721879200 176 GHVVGWYQYAQRIGDAPLQDSCLRYLSWNLSSVLQSAEWTSVSADLLLTLLRRSDLVVQSELELYDGLEAW 246
Cdd:cd18493     3 NHAVSWLQYAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKW 73

BACK (BTB and C-terminal Kelch) domain found in lectin galactoside-binding soluble 3-binding protein (LGALS3BP); LGALS3BP, also called galectin-3-binding protein, or basement membrane autoantigen p105, or Mac-2-binding protein (MAC2BP/M2BP), or tumor-associated antigen 90K, promotes integrin-mediated cell adhesion. It may stimulate host defense against viruses and tumor cells.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1721879200 182 YQYAQRIGDAPLQDSCLRYLSWNLSSVLQSAEWTSVSADLLLTLLRRSDLVVQSELELYDGLEAWA 247
Cdd:cd18496     9 YEYALSTGDALLRGLCLQYLAWNCEALISSEAWLDLPWDQLKALLTRSDLVVPDELVLLKALEAWA 74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721879200  68 SDVSLRVQTlnteevKVLPAHSLVLSLQSDVFRDLLLARNGSA----LVLSETveCAAVFDKFLRYLYCGDISVRLDQAI 143
Cdd:cd18186     2 CDVTLVVGG------REFPAHRAVLAARSPYFRAMFSSGMKESssseIELDDV--SPEAFEALLDYIYTGELELSEENVE 73

                  ....*....
gi 1721879200 144 PLHQLATKY 152
Cdd:cd18186    74 ELLAAADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Mac-2-binding protein (MAC2BP/M2BP); M2BP is also called galectin-3-binding protein, basement membrane autoantigen p105, lectin galactoside-binding soluble 3-binding protein (LGALS3BP), or tumor-associated antigen 90K. It promotes integrin-mediated cell adhesion and may stimulate host defense against viruses and tumor cells. It contains a scavenger receptor cysteine-rich domain, followed by BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721879200  51 SMALVQRMENLMALGNASDVSLRVQTLNTEEV-KVLPAHSLVLSLQSDVfrDLLLARNGSALVLSETVECAAVFDKFLRY 129
Cdd:cd18304     1 SMELSEDLGLLYDSQQGCDFNISVLTAGGEEEeLTFCAHRVILMLSPEA--NFLHKTGSSNITLDVDEECLPHVPDFLRY 78

                          90       100
                  ....*....|....*....|....*....
gi 1721879200 130 LYCGDISVRLDQAIPLHQLATKYRVEGLQ 158
Cdd:cd18304    79 FYTRQIDITLTSVKCFHKLASIYGVRKLR 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721879200  47 VLNHSMALVQRMENLMALGNASDVSLRVqtlntEEVKvLPAHSLVLSLQSDVFRDLLLA----RNGSALVLSETVecAAV 122
Cdd:cd18287     2 EIDHVHFLSEDIGALFLNEEYSDVTFVV-----EEKR-FPAHRVILAARSEYFRALLYGgmreSQQSEIELKDTN--AEA 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1721879200 123 FDKFLRYLYCGDIS---VRLDQAIPLHQLATKYRVEGLQLGLTQF 164
Cdd:cd18287    74 FKALLKYIYTGRLTltdLKEDVLLDVLGLAHQYGFEELEAAISDY 118

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721879200  68 SDVSLRVQTlnteevKVLPAHSLVLSLQSDVFRDLLLAR----NGSALVLsETVEcAAVFDKFLRYLYCGDISVRLDQAI 143
Cdd:cd18314     7 SDVVLCVGD------RKFFAHRIVLCARSPVFRSMLTGSmiesNLKEVTL-EDVE-PEIFETVLKYMYTGQVTLSEENVL 78

                          90
                  ....*....|....
gi 1721879200 144 PLHQLATKYRVEGL 157
Cdd:cd18314    79 DLLMLASKYQVPDL 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721879200  68 SDVSLRVqtlnteEVKVLPAHSLVLSLQSDVFRDLLlaRNGSALVLSETVECA----AVFDKFLRYLYCGDIS---VRLD 140
Cdd:cd18297    13 SDVTFLV------EGRPFYAHKIVLVTASDRFKSML--SSGSTEAQTPVIEIPdiryDIFQLMMQYLYTGGVEsldVAQD 84

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1721879200 141 QAIPLHQLATKYRVEGLQLGLTQFMSQHLSSES 173
Cdd:cd18297    85 DALELLRAASFFQLDGLKRHCEILLSQQIDLDN 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721879200  67 ASDVSLRVQtlNTEEVKVLPAHSLVLSLQSDVFRDLL---LARNGSALVLSEtVECAAvFDKFLRYLYCGDISVRLDQAI 143
Cdd:cd18282     7 MADVHFIVG--PPGGTQRIPAHKYVLATGSSVFYAMFyggLAENKNEIEIPD-VEPAA-FLNLLRYLYCDEIDLEPDTVL 82

                          90       100
                  ....*....|....*....|....*.
gi 1721879200 144 PLHQLATKYRVEGLQLGLTQFMSQHL 169
Cdd:cd18282    83 ATLYAAKKYLVPHLARACVQFLETSL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721879200  85 LPAHSLVLSLQSDVFRDLLlarNGSALVLSETVEC----AAVFDKFLRYLYCGDISVRLDQAIPLHQLATKYRVEGLQLG 160
Cdd:cd18281    38 IPAHKFVLSIGSAVFDAMF---NGGMATTSAEIELpdvePAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESA 114

                          90
                  ....*....|..
gi 1721879200 161 LTQFMSQHLSSE 172
Cdd:cd18281   115 CVEFLKKNLSSD 126

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1721879200 193 LQDSCLRYLSWNLSSVLQSAEWTSVSADLLLTLLRRsDLVVQSELELYDGLEAWAARNRPGGPTAERALEAIR 265
Cdd:cd14822    21 LCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSR-DSFCAPEVDIFNAVRRWCEHNPDSKEDAKEILEAVR 92

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721879200 179 VGWYQYAQRIGDAPLQDSCLRYLSWNLSSVLQSAEWTSVSADLLLTLLRRSDLVVQSELELYDGLEAWAARNRPGGPT-A 257
Cdd:cd18466     7 IGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKRKKhV 86

                          90
                  ....*....|....*..
gi 1721879200 258 ERALEAIRYGMIPPQKL 274
Cdd:cd18466    87 VEVLEPVRFPLLPPQRL 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721879200  68 SDVSLRVQTlnteevKVLPAHSLVLSLQSDVFRDLLLArNGSALVLSETVEcaAVFDKFLRYLYCGDISVRLDQ--AIPL 145
Cdd:cd18303    19 SDITIKLAD------KSIPAHKFVLAARSEKWSNENLA-STNELDLSDISY--EVVLALLRWLYTDELDLTLDDefLLEL 89

                          90
                  ....*....|...
gi 1721879200 146 HQLATKYRVEGLQ 158
Cdd:cd18303    90 MKAAKRFQLTDLV 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721879200  68 SDVSLRVqtlnTEEVKVLPAHSLVLSLQSDVFRDLLLARNG-----SALVLSETVEcaAVFDKFLRYLYCGDISVRLDQA 142
Cdd:cd18294    15 SDVKFLV----GPERQEIFAHKCILAARCEVFRAMFLTGPQkestqSPLVLSDIEP--EVFRAVLEFIYTNCVTLSNHTV 88

                          90
                  ....*....|....*
gi 1721879200 143 IPLHQLATKYRVEGL 157
Cdd:cd18294    89 IEVLAAAVEYGLDEL 103

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1721879200 191 APLQDSCLRYLSWNLSSVLQSAEWTSVSADLLLTLLRRSDLVVQSELELYDGLEAW 246
Cdd:cd18474    19 APLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRW 74

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1721879200  83 KVLPAHSLVLSLQSDVFRDLLLARNGS---ALVLSE-TVEcaaVFDKFLRYLYCGDISVRLDQAIPLHQLA 149
Cdd:cd18315    11 GSLKAHKLVLAAASPYFAALLKETPPDehpVIILPDvPYS---ELKALLDFIYTGEVNVSQEQLESLLKLA 78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721879200  50 HSMALVQRMENLMALGNASDVSLRVqtlnteEVKVLPAHSLVLSLQSDVFRDLL---LARNGSALVLSETVEcAAVFDKF 126
Cdd:cd18265     6 HAERILQVLNAYRRSGTFTDVVLLV------DGKDFPCHRATLSANSAYFRAMFgghLKESRQAVVEIQKVS-AAAMEVL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1721879200 127 LRYLYCGDISVRLDQAIPLHQLATKYRVEGLQLGLTQFMSQHLS 170
Cdd:cd18265    79 LDYMYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLH 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721879200  50 HSMALVQRMENLMALGNASDVSLRVqtlnteEVKVLPAHSLVLSLQSDVFRDLLlaRNGSALVLSETVE----CAAVFDK 125
Cdd:cd18242     4 HAKSILNTMNSLRKSNTLCDVTLRV------EGKEFPAHRIVLAACSDYFCAMF--TSEMSEKGKSEVElqglTASTMEI 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1721879200 126 FLRYLYCGDISVRLDQAIPLHQLATKYRVEGLQLGLTQFMSQHL 169
Cdd:cd18242    76 LLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1721879200 122 VFDKFLRYLYCGDISVRLDQAIPLHQLATKYRVEGL 157
Cdd:cd18298    63 VYYAFLRYLYTDQVDLPPEDAIGLLDLANSYCEERL 98