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Conserved domains on  [gi|1721862545|ref|XP_030221878|]
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interferon-inducible GTPase 5-like [Gadus morhua]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IIGP super family cl27085
Interferon-inducible GTPase (IIGP); Interferon-inducible GTPase (IIGP) is thought to play a ...
 72-453 9.98e-115

Interferon-inducible GTPase (IIGP); Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.


The actual alignment was detected with superfamily member pfam05049:

Pssm-ID: 461536 [Multi-domain]  Cd Length: 375  Bit Score: 341.77  E-value: 9.98e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545  72 VIEDIKKALEKNDTDSAALITQKYLGDINNISLNIAVTGESGVGKSTFVNAFRGIDNRDEGAAPTGVVETTMKPEPYPHP 151
Cdd:pfam05049   4 VITLIEKALREGNLQKVVSIIKKAIQEISSAPLKIAVTGDSGNGKSSFINALRGIGHEEDGSAPTGVVETTMKRTPYSHP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 152 RHPNVTLWDLPGVGTTKFPADQYLKYVEFEKFDFFIIVSADRLSENDAKLAQEIKKIGRKFYFVRSKIDNNLS-DAKRSQ 230
Cdd:pfam05049  84 HFPNVVLWDLPGLGATNFTVESYLEEMKFSEYDFFIIISSERFSLNDVKLAKAIQRMGKRFYFVRTKLDSDLSnEQKGKP 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 231 REYDEEKTLQEIRENCIQGLEKQGVASPQVFLVSSFHLHLYDFPALQDTMERELPSHKRDFLILVLPNICKSTIYKKKEV 310
Cdd:pfam05049 164 QTFPKEKVLQNIQDNCRNNLQKEGVKEPPIFLVSNLDPSHYDFPKLRDTLLKDLPIIKRHNFLLSLPNITDKTIEKKRQS 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 311 FRSRIKYYAILSAFVAAVPIPGLSIAADSSIVAKVLQDYLNGLGLDEKSLEKVSNATKRSLSDVRAGMKClcsgQNVTKE 390
Cdd:pfam05049 244 LKQKIWLEALKAAAVSIIPSLTFLGDSDLENLEECLKFYRSYFGLDDTSLQQVARDLGIEVDDFKAMLKS----PAFFKL 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1721862545 391 HVNSMLKHSVYPTVlvaaEEGSRmlpVLKIPIAALLSFTSIYRVLTSTLESLSVDAENVLMEA 453
Cdd:pfam05049 320 TKDDSILARLTRYI----NAFCR---VLGGPLCVNTYLREIYYLRYLFLDIVAEDAKTLLRKI 375
 
Name Accession Description Interval E-value
IIGP pfam05049
Interferon-inducible GTPase (IIGP); Interferon-inducible GTPase (IIGP) is thought to play a ...
 72-453 9.98e-115

Interferon-inducible GTPase (IIGP); Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.


Pssm-ID: 461536 [Multi-domain]  Cd Length: 375  Bit Score: 341.77  E-value: 9.98e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545  72 VIEDIKKALEKNDTDSAALITQKYLGDINNISLNIAVTGESGVGKSTFVNAFRGIDNRDEGAAPTGVVETTMKPEPYPHP 151
Cdd:pfam05049   4 VITLIEKALREGNLQKVVSIIKKAIQEISSAPLKIAVTGDSGNGKSSFINALRGIGHEEDGSAPTGVVETTMKRTPYSHP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 152 RHPNVTLWDLPGVGTTKFPADQYLKYVEFEKFDFFIIVSADRLSENDAKLAQEIKKIGRKFYFVRSKIDNNLS-DAKRSQ 230
Cdd:pfam05049  84 HFPNVVLWDLPGLGATNFTVESYLEEMKFSEYDFFIIISSERFSLNDVKLAKAIQRMGKRFYFVRTKLDSDLSnEQKGKP 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 231 REYDEEKTLQEIRENCIQGLEKQGVASPQVFLVSSFHLHLYDFPALQDTMERELPSHKRDFLILVLPNICKSTIYKKKEV 310
Cdd:pfam05049 164 QTFPKEKVLQNIQDNCRNNLQKEGVKEPPIFLVSNLDPSHYDFPKLRDTLLKDLPIIKRHNFLLSLPNITDKTIEKKRQS 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 311 FRSRIKYYAILSAFVAAVPIPGLSIAADSSIVAKVLQDYLNGLGLDEKSLEKVSNATKRSLSDVRAGMKClcsgQNVTKE 390
Cdd:pfam05049 244 LKQKIWLEALKAAAVSIIPSLTFLGDSDLENLEECLKFYRSYFGLDDTSLQQVARDLGIEVDDFKAMLKS----PAFFKL 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1721862545 391 HVNSMLKHSVYPTVlvaaEEGSRmlpVLKIPIAALLSFTSIYRVLTSTLESLSVDAENVLMEA 453
Cdd:pfam05049 320 TKDDSILARLTRYI----NAFCR---VLGGPLCVNTYLREIYYLRYLFLDIVAEDAKTLLRKI 375
p47_IIGP_like cd04104
p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1; The p47 GTPase ...
 104-298 9.03e-107

p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1; The p47 GTPase family consists of several highly homologous proteins, including IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1. They are found in higher eukaryotes where they play a role in immune resistance against intracellular pathogens. p47 proteins exist at low resting levels in mouse cells, but are strongly induced by Type II interferon (IFN-gamma). ITGP is critical for resistance to Toxoplasma gondii infection and in involved in inhibition of Coxsackievirus-B3-induced apoptosis. TGTP was shown to limit vesicular stomatitis virus (VSV) infection of fibroblasts in vitro. IRG-47 is involved in resistance to T. gondii infection. LRG-47 has been implicated in resistance to T. gondii, Listeria monocytogenes, Leishmania, and mycobacterial infections. IIGP1 has been shown to localize to the ER and to the Golgi membranes in IFN-induced cells and inflamed tissues. In macrophages, IIGP1 interacts with hook3, a microtubule binding protein that participates in the organization of the cis-Golgi compartment.


Pssm-ID: 206690  Cd Length: 197  Bit Score: 314.65  E-value: 9.03e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 104 LNIAVTGESGVGKSTFVNAFRGIDNRDEGAAPTGVVETTMKPEPYPHPRHPNVTLWDLPGVGTTKFPADQYLKYVEFEKF 183
Cdd:cd04104     2 LNIAVTGESGAGKSSFINALRGIGHEEEGAAPTGVVETTMKRTPYPHPKFPNVTLWDLPGIGSTAFPPDDYLEEMKFSEY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 184 DFFIIVSADRLSENDAKLAQEIKKIGRKFYFVRSKIDNNLSDAKRSQ-REYDEEKTLQEIRENCIQGLEKQGVASPQVFL 262
Cdd:cd04104    82 DFFIIISSTRFSSNDVKLAKAIQMMGKKFYFVRTKVDSDLSNEQRSKpRSFNKEQVLQQIRDNCLENLQEAGVSEPPVFL 161

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1721862545 263 VSSFHLHLYDFPALQDTMERELPSHKRDFLILVLPN 298
Cdd:cd04104   162 VSNFDPSDYDFPKLRDTLLKDLPAHKRHNFLLSLPN 197
YeeP COG3596
Predicted GTPase [General function prediction only];
67-289 1.43e-14

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 74.42  E-value: 1.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545  67 ALESKVIEDIKKALEKNDTDSAALITQKY-LGDINNISLNIAVTGESGVGKSTFVNAFRGidnrdEGAAPTGVVE-TTMK 144
Cdd:COG3596     2 STEVSSLTERLEALKRLPQVLRELLAEALeRLLVELPPPVIALVGKTGAGKSSLINALFG-----AEVAEVGVGRpCTRE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 145 PEPYPHPRH--PNVTLWDLPGVGTTKFPADQYLKYVEF-EKFDFFI-IVSA-DRLSENDAKLAQEIKK--IGRKFYFVRS 217
Cdd:COG3596    77 IQRYRLESDglPGLVLLDTPGLGEVNERDREYRELRELlPEADLILwVVKAdDRALATDEEFLQALRAqyPDPPVLVVLT 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1721862545 218 KIDnNLSDAKRSQREYD--EEKTLQEIRENCIQGLEKQGVASPQVFLVSSFHLHL-YDFPALQDTMERELPSHKR 289
Cdd:COG3596   157 QVD-RLEPEREWDPPYNwpSPPKEQNIRRALEAIAEQLGVPIDRVIPVSAAEDRTgYGLEELVDALAEALPEAKR 230
 
Name Accession Description Interval E-value
IIGP pfam05049
Interferon-inducible GTPase (IIGP); Interferon-inducible GTPase (IIGP) is thought to play a ...
 72-453 9.98e-115

Interferon-inducible GTPase (IIGP); Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localizes to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.


Pssm-ID: 461536 [Multi-domain]  Cd Length: 375  Bit Score: 341.77  E-value: 9.98e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545  72 VIEDIKKALEKNDTDSAALITQKYLGDINNISLNIAVTGESGVGKSTFVNAFRGIDNRDEGAAPTGVVETTMKPEPYPHP 151
Cdd:pfam05049   4 VITLIEKALREGNLQKVVSIIKKAIQEISSAPLKIAVTGDSGNGKSSFINALRGIGHEEDGSAPTGVVETTMKRTPYSHP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 152 RHPNVTLWDLPGVGTTKFPADQYLKYVEFEKFDFFIIVSADRLSENDAKLAQEIKKIGRKFYFVRSKIDNNLS-DAKRSQ 230
Cdd:pfam05049  84 HFPNVVLWDLPGLGATNFTVESYLEEMKFSEYDFFIIISSERFSLNDVKLAKAIQRMGKRFYFVRTKLDSDLSnEQKGKP 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 231 REYDEEKTLQEIRENCIQGLEKQGVASPQVFLVSSFHLHLYDFPALQDTMERELPSHKRDFLILVLPNICKSTIYKKKEV 310
Cdd:pfam05049 164 QTFPKEKVLQNIQDNCRNNLQKEGVKEPPIFLVSNLDPSHYDFPKLRDTLLKDLPIIKRHNFLLSLPNITDKTIEKKRQS 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 311 FRSRIKYYAILSAFVAAVPIPGLSIAADSSIVAKVLQDYLNGLGLDEKSLEKVSNATKRSLSDVRAGMKClcsgQNVTKE 390
Cdd:pfam05049 244 LKQKIWLEALKAAAVSIIPSLTFLGDSDLENLEECLKFYRSYFGLDDTSLQQVARDLGIEVDDFKAMLKS----PAFFKL 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1721862545 391 HVNSMLKHSVYPTVlvaaEEGSRmlpVLKIPIAALLSFTSIYRVLTSTLESLSVDAENVLMEA 453
Cdd:pfam05049 320 TKDDSILARLTRYI----NAFCR---VLGGPLCVNTYLREIYYLRYLFLDIVAEDAKTLLRKI 375
p47_IIGP_like cd04104
p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1; The p47 GTPase ...
 104-298 9.03e-107

p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1; The p47 GTPase family consists of several highly homologous proteins, including IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1. They are found in higher eukaryotes where they play a role in immune resistance against intracellular pathogens. p47 proteins exist at low resting levels in mouse cells, but are strongly induced by Type II interferon (IFN-gamma). ITGP is critical for resistance to Toxoplasma gondii infection and in involved in inhibition of Coxsackievirus-B3-induced apoptosis. TGTP was shown to limit vesicular stomatitis virus (VSV) infection of fibroblasts in vitro. IRG-47 is involved in resistance to T. gondii infection. LRG-47 has been implicated in resistance to T. gondii, Listeria monocytogenes, Leishmania, and mycobacterial infections. IIGP1 has been shown to localize to the ER and to the Golgi membranes in IFN-induced cells and inflamed tissues. In macrophages, IIGP1 interacts with hook3, a microtubule binding protein that participates in the organization of the cis-Golgi compartment.


Pssm-ID: 206690  Cd Length: 197  Bit Score: 314.65  E-value: 9.03e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 104 LNIAVTGESGVGKSTFVNAFRGIDNRDEGAAPTGVVETTMKPEPYPHPRHPNVTLWDLPGVGTTKFPADQYLKYVEFEKF 183
Cdd:cd04104     2 LNIAVTGESGAGKSSFINALRGIGHEEEGAAPTGVVETTMKRTPYPHPKFPNVTLWDLPGIGSTAFPPDDYLEEMKFSEY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 184 DFFIIVSADRLSENDAKLAQEIKKIGRKFYFVRSKIDNNLSDAKRSQ-REYDEEKTLQEIRENCIQGLEKQGVASPQVFL 262
Cdd:cd04104    82 DFFIIISSTRFSSNDVKLAKAIQMMGKKFYFVRTKVDSDLSNEQRSKpRSFNKEQVLQQIRDNCLENLQEAGVSEPPVFL 161

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1721862545 263 VSSFHLHLYDFPALQDTMERELPSHKRDFLILVLPN 298
Cdd:cd04104   162 VSNFDPSDYDFPKLRDTLLKDLPAHKRHNFLLSLPN 197
YeeP COG3596
Predicted GTPase [General function prediction only];
67-289 1.43e-14

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 74.42  E-value: 1.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545  67 ALESKVIEDIKKALEKNDTDSAALITQKY-LGDINNISLNIAVTGESGVGKSTFVNAFRGidnrdEGAAPTGVVE-TTMK 144
Cdd:COG3596     2 STEVSSLTERLEALKRLPQVLRELLAEALeRLLVELPPPVIALVGKTGAGKSSLINALFG-----AEVAEVGVGRpCTRE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 145 PEPYPHPRH--PNVTLWDLPGVGTTKFPADQYLKYVEF-EKFDFFI-IVSA-DRLSENDAKLAQEIKK--IGRKFYFVRS 217
Cdd:COG3596    77 IQRYRLESDglPGLVLLDTPGLGEVNERDREYRELRELlPEADLILwVVKAdDRALATDEEFLQALRAqyPDPPVLVVLT 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1721862545 218 KIDnNLSDAKRSQREYD--EEKTLQEIRENCIQGLEKQGVASPQVFLVSSFHLHL-YDFPALQDTMERELPSHKR 289
Cdd:COG3596   157 QVD-RLEPEREWDPPYNwpSPPKEQNIRRALEAIAEQLGVPIDRVIPVSAAEDRTgYGLEELVDALAEALPEAKR 230
DLP_2 cd09912
Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; The ...
 104-292 7.29e-12

Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; The dynamin family of large mechanochemical GTPases includes the classical dynamins and dynamin-like proteins (DLPs) that are found throughout the Eukarya. This family also includes bacterial DLPs. These proteins catalyze membrane fission during clathrin-mediated endocytosis. Dynamin consists of five domains; an N-terminal G domain that binds and hydrolyzes GTP, a middle domain (MD) involved in self-assembly and oligomerization, a pleckstrin homology (PH) domain responsible for interactions with the plasma membrane, GED, which is also involved in self-assembly, and a proline arginine rich domain (PRD) that interacts with SH3 domains on accessory proteins. To date, three vertebrate dynamin genes have been identified; dynamin 1, which is brain specific, mediates uptake of synaptic vesicles in presynaptic terminals; dynamin-2 is expressed ubiquitously and similarly participates in membrane fission; mutations in the MD, PH and GED domains of dynamin 2 have been linked to human diseases such as Charcot-Marie-Tooth peripheral neuropathy and rare forms of centronuclear myopathy. Dynamin 3 participates in megakaryocyte progenitor amplification, and is also involved in cytoplasmic enlargement and the formation of the demarcation membrane system. This family also includes mitofusins (MFN1 and MFN2 in mammals) that are involved in mitochondrial fusion. Dynamin oligomerizes into helical structures around the neck of budding vesicles in a GTP hydrolysis-dependent manner.


Pssm-ID: 206739 [Multi-domain]  Cd Length: 180  Bit Score: 63.72  E-value: 7.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 104 LNIAVTGESGVGKSTFVNAFRGidnrdEGAAPTGVVETTMKPEpypHPRH---PNVTLWDLPGVGTTkFPADQYLKYVEF 180
Cdd:cd09912     1 FLLAVVGEFSAGKSTLLNALLG-----EEVLPTGVTPTTAVIT---VLRYgllKGVVLVDTPGLNST-IEHHTEITESFL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 181 EKFDFFIIV-SADR-LSENDAKLAQEIKK-IGRKFYFVRSKIDnNLSDAKRSQREYDEEKTLQEIREnciqglekqGVAS 257
Cdd:cd09912    72 PRADAVIFVlSADQpLTESEREFLKEILKwSGKKIFFVLNKID-LLSEEELEEVLEYSREELGVLEL---------GGGE 141

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1721862545 258 PQVFLVSS----FHLHLYDFPALQDTMERELPSHKRDFL 292
Cdd:cd09912   142 PRIFPVSAkealEARLQGDEELLEQSGFEELEEHLEEFL 180
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 107-247 1.56e-11

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 62.47  E-value: 1.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 107 AVTGESGVGKSTFVNAFRGidnrDEGAAPTGVVETTMKPEPYPHPRHP---NVTLWDLPGVGTTKFPADQYLKYVEFEKF 183
Cdd:cd00882     1 VVVGRGGVGKSSLLNALLG----GEVGEVSDVPGTTRDPDVYVKELDKgkvKLVLVDTPGLDEFGGLGREELARLLLRGA 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1721862545 184 DFFIIV--SADRLSENDAKLAQEIKKIGRK--FYFVRSKIDnnLSDAKRSQREYDEEKTLQEIRENCI 247
Cdd:cd00882    77 DLILLVvdSTDRESEEDAKLLILRRLRKEGipIILVGNKID--LLEEREVEELLRLEELAKILGVPVF 142
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
101-245 7.17e-06

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 46.13  E-value: 7.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 101 NISLNIAVTGESGVGKSTFVNAF-RGIDNRDEGAAPTGVveTTMKPEPYPHPRHPNVTLWDLPGV----GTTKFpadqYL 175
Cdd:COG1100     1 MGEKKIVVVGTGGVGKTSLVNRLvGDIFSLEKYLSTNGV--TIDKKELKLDGLDVDLVIWDTPGQdefrETRQF----YA 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1721862545 176 KyvEFEKFDFFIIVSADRLSENDA---KLAQEIKKIGRK--FYFVRSKIDnnlsdaKRSQREYDEEKTLQEIREN 245
Cdd:COG1100    75 R--QLTGASLYLFVVDGTREETLQslyELLESLRRLGKKspIILVLNKID------LYDEEEIEDEERLKEALSE 141
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 105-218 4.05e-04

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 39.91  E-value: 4.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 105 NIAVTGESGVGKSTFVNAFRGidnrdEGAAPTGVVETTMKPEPYP-HPRHPNVTLWDLPG-VGTTKFPADQYLKYVEFEK 182
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTG-----AKAIVSDYPGTTRDPNEGRlELKGKQIILVDTPGlIEGASEGEGLGRAFLAIIE 75

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1721862545 183 FD--FFIIVSADRLSENDAKLAQEIKKIGRKFYFVRSK 218
Cdd:pfam01926  76 ADliLFVVDSEEGITPLDEELLELLRENKKPIILVLNK 113
YfjP cd11383
YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several ...
 107-179 8.44e-04

YfjP GTPase; The Era (E. coli Ras-like protein)-like YfjP subfamily includes several uncharacterized bacterial GTPases that are similar to Era. They generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain.


Pssm-ID: 206743 [Multi-domain]  Cd Length: 140  Bit Score: 39.63  E-value: 8.44e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1721862545 107 AVTGESGVGKSTFVNAFRGIdnrdEGAAPTGVVETTMKPEPYP-HPRHPNVTLWDLPGVG----TTKFPADQYLKYVE 179
Cdd:cd11383     1 GLMGKTGAGKSSLCNALFGT----EVAAVGDRRPTTRAAQAYVwQTGGDGLVLLDLPGVGergrRDREYEELYRRLLP 74
Dynamin_N pfam00350
Dynamin family;
106-179 1.00e-03

Dynamin family;


Pssm-ID: 459775 [Multi-domain]  Cd Length: 168  Bit Score: 39.91  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1721862545 106 IAVTGESGVGKSTFVNAFRGIDnrdegAAPTGVVETT-------MKPEPYPHPRHPNVTLWDlpgvGTTKF-PADQYLKY 177
Cdd:pfam00350   1 IAVVGDQSSGKSSVLNALLGRD-----ILPRGPGPTTrrptvlrLGESPGASEGAVKVEYKD----GEKKFeDFSELREE 71


                  ..
gi 1721862545 178 VE 179
Cdd:pfam00350  72 IE 73
ABC_tran pfam00005
ABC transporter; ABC transporters for a large family of proteins responsible for translocation ...
 99-132 2.09e-03

ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.


Pssm-ID: 394964 [Multi-domain]  Cd Length: 150  Bit Score: 38.40  E-value: 2.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1721862545  99 INNISLNI------AVTGESGVGKSTFVNAFRGIDNRDEG 132
Cdd:pfam00005   1 LKNVSLTLnpgeilALVGPNGAGKSTLLKLIAGLLSPTEG 40
Septin pfam00735
Septin; Members of this family include CDC3, CDC10, CDC11 and CDC12/Septin. Members of this ...
 102-165 4.19e-03

Septin; Members of this family include CDC3, CDC10, CDC11 and CDC12/Septin. Members of this family bind GTP. As regards the septins, these are polypeptides of 30-65kDa with three characteriztic GTPase motifs (G-1, G-3 and G-4) that are similar to those of the Ras family. The G-4 motif is strictly conserved with a unique septin consensus of AKAD. Most septins are thought to have at least one coiled-coil region, which in some cases is necessary for intermolecular interactions that allow septins to polymerize to form rod-shaped complexes. In turn, these are arranged into tandem arrays to form filaments. They are multifunctional proteins, with roles in cytokinesis, sporulation, germ cell development, exocytosis and apoptosis.


Pssm-ID: 395596  Cd Length: 272  Bit Score: 38.82  E-value: 4.19e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1721862545 102 ISLNIAVTGESGVGKSTFVNAFRGIDNRDEGAAPtGVVETTMKPEPYPHPR--------HPNVTLWDLPGVG 165
Cdd:pfam00735   2 FDFTLMVVGESGLGKTTFINTLFLTDLYRARGIP-GPSEKIKKTVEIKAYTveieedgvKLNLTVIDTPGFG 72
CDC_Septin cd01850
CDC/Septin GTPase family; Septins are a conserved family of GTP-binding proteins associated ...
 100-121 9.43e-03

CDC/Septin GTPase family; Septins are a conserved family of GTP-binding proteins associated with diverse processes in dividing and non-dividing cells. They were first discovered in the budding yeast S. cerevisiae as a set of genes (CDC3, CDC10, CDC11 and CDC12) required for normal bud morphology. Septins are also present in metazoan cells, where they are required for cytokinesis in some systems, and implicated in a variety of other processes involving organization of the cell cortex and exocytosis. In humans, 12 septin genes generate dozens of polypeptides, many of which comprise heterooligomeric complexes. Since septin mutants are commonly defective in cytokinesis and formation of the neck formation of the neck filaments/septin rings, septins have been considered to be the primary constituents of the neck filaments. Septins belong to the GTPase superfamily for their conserved GTPase motifs and enzymatic activities.


Pssm-ID: 206649  Cd Length: 275  Bit Score: 37.91  E-value: 9.43e-03
                          10        20
                  ....*....|....*....|..
gi 1721862545 100 NNISLNIAVTGESGVGKSTFVN 121
Cdd:cd01850     1 RGFQFNIMVVGESGLGKSTFIN 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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