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Conserved domains on  [gi|1720702545|gb|QEA11215|]
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capsid and scaffold protein [Salmonella phage Th1]

Protein Classification

HK97 family phage prohead protease( domain architecture ID 10007935)

HK97 family phage prohead protease similar to Escherichia virus HK97 prohead protease that is involved in virion assembly and maturation

EC:  3.4.21.-
Gene Ontology:  GO:0008236|GO:0046797|GO:0006508
MEROPS:  S78
PubMed:  7723019|22297521

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG3740 COG3740
Phage head maturation protease [Mobilome: prophages, transposons];
22-178 5.98e-28

Phage head maturation protease [Mobilome: prophages, transposons];


:

Pssm-ID: 442954  Cd Length: 183  Bit Score: 103.91  E-value: 5.98e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720702545  22 IKSIDsESKEGVvkIRGFA---NTISK-DRAGDVIPASAWktSNALANYMKNPIILFGHDHRRPIGKCIDLNPTEMGLEI 97
Cdd:COG3740    12 IRAVT-DDDDGT--IEGYAsvfGSPSElDRFGEVIAPGAF--AKSLAERGSDVPMLWQHDPAKPLGRWDELREDDKGLRV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720702545  98 ECEIYESSDPA--IFSLIKNGVLKTFSIGFRCLDAEW--DEATDIFIIKDLELYEVSVVSVPCNQDSTFNLAKSMNGHDY 173
Cdd:COG3740    87 EGRLLPDTPRArdVYALIKAGAIDGLSIGFRVVKDEWerDGGTGVRTILEVDLWEVSVVTFPAYPDARVSARKSALEAAE 166

                  ....*
gi 1720702545 174 TEWRK 178
Cdd:COG3740   167 AEALR 171
 
Name Accession Description Interval E-value
COG3740 COG3740
Phage head maturation protease [Mobilome: prophages, transposons];
22-178 5.98e-28

Phage head maturation protease [Mobilome: prophages, transposons];


Pssm-ID: 442954  Cd Length: 183  Bit Score: 103.91  E-value: 5.98e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720702545  22 IKSIDsESKEGVvkIRGFA---NTISK-DRAGDVIPASAWktSNALANYMKNPIILFGHDHRRPIGKCIDLNPTEMGLEI 97
Cdd:COG3740    12 IRAVT-DDDDGT--IEGYAsvfGSPSElDRFGEVIAPGAF--AKSLAERGSDVPMLWQHDPAKPLGRWDELREDDKGLRV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720702545  98 ECEIYESSDPA--IFSLIKNGVLKTFSIGFRCLDAEW--DEATDIFIIKDLELYEVSVVSVPCNQDSTFNLAKSMNGHDY 173
Cdd:COG3740    87 EGRLLPDTPRArdVYALIKAGAIDGLSIGFRVVKDEWerDGGTGVRTILEVDLWEVSVVTFPAYPDARVSARKSALEAAE 166

                  ....*
gi 1720702545 174 TEWRK 178
Cdd:COG3740   167 AEALR 171
proheadase_HK97 TIGR01543
phage prohead protease, HK97 family; This model describes the prohead protease of HK97 and ...
39-160 2.60e-18

phage prohead protease, HK97 family; This model describes the prohead protease of HK97 and related phage. It is generally encoded next to the gene for the capsid protein that it processes, and in some cases may be fused to it. This family does not show similarity to the prohead protease of phage T4 (see pfam03420). [Mobile and extrachromosomal element functions, Prophage functions, Protein fate, Other]


Pssm-ID: 273682  Cd Length: 145  Bit Score: 77.92  E-value: 2.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720702545  39 FANTISKDRAGDVIPASAWKtsNALANYMKNPIILFGHDHRRPIGK---CIDLNPTEMGLEIECEI-YESSDPA-IFSLI 113
Cdd:TIGR01543  10 FGNKDSDGWGYEVFLPGAFT--NTLAEWNDKVRLLYNHDTALPVGRtvsGTKLEEDDHGLYGRGKLpPDTPDAAdVYALV 87
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1720702545 114 KNGVLKTFSIGFRCLDAEWD--EATDIFIIKDLELYEVSVVSVPCNQDS 160
Cdd:TIGR01543  88 KAGDVSGMSFGFRVIKDVWDdrEEGDVISLLEAALYEVSVTTFPAYPEA 136
Peptidase_S78 pfam04586
Caudovirus prohead serine protease; Family of Caudovirus prohead serine proteases also found ...
27-161 9.02e-17

Caudovirus prohead serine protease; Family of Caudovirus prohead serine proteases also found in a number of bacteria possibly as the result of horizontal transfer.


Pssm-ID: 309640  Cd Length: 160  Bit Score: 73.94  E-value: 9.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720702545  27 SESKEGVVKIRGFA---NTISKDRAG--DVIPASAWktSNALANymKNPIILFGHDHRRPIGK----CIDLNPTEMGLEI 97
Cdd:pfam04586   4 RSVEEGGITISGYAsvfNTVSELLGGfrEVIAPGAF--DNTLKS--ADVPALFNHDTNKVLGRtksgTLELSEDEVGLRF 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720702545  98 ECEIyeSSDPAI---FSLIKNGVLKTFSIGFRCLDAEWDEATD---IFIIKDLELYEVSVVSVPCNQDST 161
Cdd:pfam04586  80 ELDL--PDTTVArdlYELMKRGDIDGCSFGFRVVGDSWDEREDkvpVRTITEVELIEVSIVTFPAYPDTS 147
 
Name Accession Description Interval E-value
COG3740 COG3740
Phage head maturation protease [Mobilome: prophages, transposons];
22-178 5.98e-28

Phage head maturation protease [Mobilome: prophages, transposons];


Pssm-ID: 442954  Cd Length: 183  Bit Score: 103.91  E-value: 5.98e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720702545  22 IKSIDsESKEGVvkIRGFA---NTISK-DRAGDVIPASAWktSNALANYMKNPIILFGHDHRRPIGKCIDLNPTEMGLEI 97
Cdd:COG3740    12 IRAVT-DDDDGT--IEGYAsvfGSPSElDRFGEVIAPGAF--AKSLAERGSDVPMLWQHDPAKPLGRWDELREDDKGLRV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720702545  98 ECEIYESSDPA--IFSLIKNGVLKTFSIGFRCLDAEW--DEATDIFIIKDLELYEVSVVSVPCNQDSTFNLAKSMNGHDY 173
Cdd:COG3740    87 EGRLLPDTPRArdVYALIKAGAIDGLSIGFRVVKDEWerDGGTGVRTILEVDLWEVSVVTFPAYPDARVSARKSALEAAE 166

                  ....*
gi 1720702545 174 TEWRK 178
Cdd:COG3740   167 AEALR 171
proheadase_HK97 TIGR01543
phage prohead protease, HK97 family; This model describes the prohead protease of HK97 and ...
39-160 2.60e-18

phage prohead protease, HK97 family; This model describes the prohead protease of HK97 and related phage. It is generally encoded next to the gene for the capsid protein that it processes, and in some cases may be fused to it. This family does not show similarity to the prohead protease of phage T4 (see pfam03420). [Mobile and extrachromosomal element functions, Prophage functions, Protein fate, Other]


Pssm-ID: 273682  Cd Length: 145  Bit Score: 77.92  E-value: 2.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720702545  39 FANTISKDRAGDVIPASAWKtsNALANYMKNPIILFGHDHRRPIGK---CIDLNPTEMGLEIECEI-YESSDPA-IFSLI 113
Cdd:TIGR01543  10 FGNKDSDGWGYEVFLPGAFT--NTLAEWNDKVRLLYNHDTALPVGRtvsGTKLEEDDHGLYGRGKLpPDTPDAAdVYALV 87
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1720702545 114 KNGVLKTFSIGFRCLDAEWD--EATDIFIIKDLELYEVSVVSVPCNQDS 160
Cdd:TIGR01543  88 KAGDVSGMSFGFRVIKDVWDdrEEGDVISLLEAALYEVSVTTFPAYPEA 136
Peptidase_S78 pfam04586
Caudovirus prohead serine protease; Family of Caudovirus prohead serine proteases also found ...
27-161 9.02e-17

Caudovirus prohead serine protease; Family of Caudovirus prohead serine proteases also found in a number of bacteria possibly as the result of horizontal transfer.


Pssm-ID: 309640  Cd Length: 160  Bit Score: 73.94  E-value: 9.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720702545  27 SESKEGVVKIRGFA---NTISKDRAG--DVIPASAWktSNALANymKNPIILFGHDHRRPIGK----CIDLNPTEMGLEI 97
Cdd:pfam04586   4 RSVEEGGITISGYAsvfNTVSELLGGfrEVIAPGAF--DNTLKS--ADVPALFNHDTNKVLGRtksgTLELSEDEVGLRF 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720702545  98 ECEIyeSSDPAI---FSLIKNGVLKTFSIGFRCLDAEWDEATD---IFIIKDLELYEVSVVSVPCNQDST 161
Cdd:pfam04586  80 ELDL--PDTTVArdlYELMKRGDIDGCSFGFRVVGDSWDEREDkvpVRTITEVELIEVSIVTFPAYPDTS 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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