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Conserved domains on  [gi|1720418823|ref|XP_030111456|]
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solute carrier family 41 member 3 isoform X5 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 153-297 3.36e-17

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


:

Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 76.33  E-value: 3.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418823 153 TPVMCGVGGNLVAIQTSRISTFLHMWSTPgvlpvqmkrfwPNPCFIFCSSEINSVSARVLLFLVVPGHLIFFYLICLveg 232
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEIE-----------PRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGL--- 66

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720418823 233 qsvtnskIFILLYLVAGVVQVVILLYLAEVTVRLTWHQALDPDNHCIPYLTGLGDLLGTSLLALC 297
Cdd:pfam01769  67 -------LLGLVVGLALLLAVLIALLLGTLLPLLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 14-74 5.22e-07

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


:

Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 47.82  E-value: 5.22e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720418823  14 KVALLCTSSVITAFLAALALGILMiciVIGARKFGVNPDNIATPIAASLGDLITLSILALM 74
Cdd:pfam01769  67 LLGLVVGLALLLAVLIALLLGTLL---PLLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
 
Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 153-297 3.36e-17

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 76.33  E-value: 3.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418823 153 TPVMCGVGGNLVAIQTSRISTFLHMWSTPgvlpvqmkrfwPNPCFIFCSSEINSVSARVLLFLVVPGHLIFFYLICLveg 232
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEIE-----------PRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGL--- 66

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720418823 233 qsvtnskIFILLYLVAGVVQVVILLYLAEVTVRLTWHQALDPDNHCIPYLTGLGDLLGTSLLALC 297
Cdd:pfam01769  67 -------LLGLVVGLALLLAVLIALLLGTLLPLLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
114-294 1.63e-10

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 59.49  E-value: 1.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418823 114 KILKYGWFPIILAMIISSFGGLILSKTISK-HEFKGMAVLTPVMCGVGGNLVAIQTSRISTFLHMwstpGVLPvqmKRFW 192
Cdd:COG1824     9 RIVRESLPVLLVLAVGGIIAGLVLEGMEELlLAYPGLLVLVPAFLGTRGNLGGILGARLSTALHL----GLLE---PRLR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418823 193 PNPCFIFCSSEINSVSARVLLFLVVPGHLIffyliCLVEGQSVTNSKIFILLYLVAGVVQVVILLYLAEVTVRLTWHQAL 272
Cdd:COG1824    82 PDRRLLNNILATLILALLISPLIGVLAWLV-----AVLLGRGSLGLLTLVGIALLAGLLLALLLIVVTYYVAIASYRFGL 156

                         170       180
                  ....*....|....*....|..
gi 1720418823 273 DPDNHCIPYLTGLGDLLGTSLL 294
Cdd:COG1824   157 DPDNVVIPVVTTLGDVFGVLFL 178
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 14-74 5.22e-07

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 47.82  E-value: 5.22e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720418823  14 KVALLCTSSVITAFLAALALGILMiciVIGARKFGVNPDNIATPIAASLGDLITLSILALM 74
Cdd:pfam01769  67 LLGLVVGLALLLAVLIALLLGTLL---PLLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
22-78 2.83e-03

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 38.31  E-value: 2.83e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720418823  22 SVITAFLAALALGILMICIVIGARKFGVNPDNIATPIAASLGDLITLSILALMSSFF 78
Cdd:COG1824   129 ALLAGLLLALLLIVVTYYVAIASYRFGLDPDNVVIPVVTTLGDVFGVLFLILVARLV 185
 
Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 153-297 3.36e-17

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 76.33  E-value: 3.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418823 153 TPVMCGVGGNLVAIQTSRISTFLHMWSTPgvlpvqmkrfwPNPCFIFCSSEINSVSARVLLFLVVPGHLIFFYLICLveg 232
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEIE-----------PRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGL--- 66

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720418823 233 qsvtnskIFILLYLVAGVVQVVILLYLAEVTVRLTWHQALDPDNHCIPYLTGLGDLLGTSLLALC 297
Cdd:pfam01769  67 -------LLGLVVGLALLLAVLIALLLGTLLPLLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
114-294 1.63e-10

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 59.49  E-value: 1.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418823 114 KILKYGWFPIILAMIISSFGGLILSKTISK-HEFKGMAVLTPVMCGVGGNLVAIQTSRISTFLHMwstpGVLPvqmKRFW 192
Cdd:COG1824     9 RIVRESLPVLLVLAVGGIIAGLVLEGMEELlLAYPGLLVLVPAFLGTRGNLGGILGARLSTALHL----GLLE---PRLR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418823 193 PNPCFIFCSSEINSVSARVLLFLVVPGHLIffyliCLVEGQSVTNSKIFILLYLVAGVVQVVILLYLAEVTVRLTWHQAL 272
Cdd:COG1824    82 PDRRLLNNILATLILALLISPLIGVLAWLV-----AVLLGRGSLGLLTLVGIALLAGLLLALLLIVVTYYVAIASYRFGL 156

                         170       180
                  ....*....|....*....|..
gi 1720418823 273 DPDNHCIPYLTGLGDLLGTSLL 294
Cdd:COG1824   157 DPDNVVIPVVTTLGDVFGVLFL 178
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 14-74 5.22e-07

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 47.82  E-value: 5.22e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720418823  14 KVALLCTSSVITAFLAALALGILMiciVIGARKFGVNPDNIATPIAASLGDLITLSILALM 74
Cdd:pfam01769  67 LLGLVVGLALLLAVLIALLLGTLL---PLLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
22-78 2.83e-03

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 38.31  E-value: 2.83e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720418823  22 SVITAFLAALALGILMICIVIGARKFGVNPDNIATPIAASLGDLITLSILALMSSFF 78
Cdd:COG1824   129 ALLAGLLLALLLIVVTYYVAIASYRFGLDPDNVVIPVVTTLGDVFGVLFLILVARLV 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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