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Conserved domains on  [gi|1720390309|ref|XP_030105697|]
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uncharacterized protein LOC319615 isoform X2 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12017129)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
13-52 4.28e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 88.68  E-value: 4.28e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1720390309  13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFV 52
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
321-484 4.31e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 4.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390309 321 KPYKCGKCEKCFTHKGDLRSHQR--IHTGE--KPYKCSE--CDKCFTHKRSLRSHQRIHTGEKPYKCSECDKCFTHKRSL 394
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390309 395 -------SIHQIIHTEEKPYRCSGCDKIFNHKGD--LRNHQRIHTGQKP--YKCSECDKCFVHKYSLSIHQRIHTgEKPY 463
Cdd:COG5048   368 nneppqsLQQYKDLKNDKKSETLSNSCIRNFKRDsnLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAP 446
                         170       180
                  ....*....|....*....|.
gi 1720390309 464 KCNECNEFFRYKCSLRTHQKM 484
Cdd:COG5048   447 LLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
253-278 6.07e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720390309 253 DLRIHQRIHTGEKPYKCIECDKSFTQ 278
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
198-222 3.69e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.69e-03
                          10        20
                  ....*....|....*....|....*
gi 1720390309 198 LRQHQIIHTGEKPYRCSQCDKCFSQ 222
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-306 3.92e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.92e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390309 281 HLIIHQRIHTGEKPYKCSECDKCFTQ 306
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
13-52 4.28e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 88.68  E-value: 4.28e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1720390309  13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFV 52
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-55 1.36e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 88.03  E-value: 1.36e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1720390309   13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFVENH 55
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
13-51 1.17e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.17e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720390309  13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFF 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
321-484 4.31e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 4.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390309 321 KPYKCGKCEKCFTHKGDLRSHQR--IHTGE--KPYKCSE--CDKCFTHKRSLRSHQRIHTGEKPYKCSECDKCFTHKRSL 394
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390309 395 -------SIHQIIHTEEKPYRCSGCDKIFNHKGD--LRNHQRIHTGQKP--YKCSECDKCFVHKYSLSIHQRIHTgEKPY 463
Cdd:COG5048   368 nneppqsLQQYKDLKNDKKSETLSNSCIRNFKRDsnLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAP 446
                         170       180
                  ....*....|....*....|.
gi 1720390309 464 KCNECNEFFRYKCSLRTHQKM 484
Cdd:COG5048   447 LLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
365-390 5.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.39e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720390309 365 SLRSHQRIHTGEKPYKCSECDKCFTH 390
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
253-278 6.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720390309 253 DLRIHQRIHTGEKPYKCIECDKSFTQ 278
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
198-222 3.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.69e-03
                          10        20
                  ....*....|....*....|....*
gi 1720390309 198 LRQHQIIHTGEKPYRCSQCDKCFSQ 222
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-306 3.92e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.92e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390309 281 HLIIHQRIHTGEKPYKCSECDKCFTQ 306
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-322 4.40e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 4.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390309 265 KPYKCIECDKSFTQKGHLIIHQRIHTGEKPYKCS--ECDKCFTQKCSLTIHQRIHTGEKP 322
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPS 91
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
13-52 4.28e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 88.68  E-value: 4.28e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1720390309  13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFV 52
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
13-55 1.36e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 88.03  E-value: 1.36e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1720390309   13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFFVENH 55
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
13-51 1.17e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 79.13  E-value: 1.17e-18
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720390309  13 LTFKDVAVDFSQEEWECLDCAQRALYMDVMLENYNNLFF 51
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
321-484 4.31e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 4.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390309 321 KPYKCGKCEKCFTHKGDLRSHQR--IHTGE--KPYKCSE--CDKCFTHKRSLRSHQRIHTGEKPYKCSECDKCFTHKRSL 394
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390309 395 -------SIHQIIHTEEKPYRCSGCDKIFNHKGD--LRNHQRIHTGQKP--YKCSECDKCFVHKYSLSIHQRIHTgEKPY 463
Cdd:COG5048   368 nneppqsLQQYKDLKNDKKSETLSNSCIRNFKRDsnLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAP 446
                         170       180
                  ....*....|....*....|.
gi 1720390309 464 KCNECNEFFRYKCSLRTHQKM 484
Cdd:COG5048   447 LLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-416 5.18e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 5.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390309 265 KPYKCIECDKSFTQKGHLIIHQR--IHTGE--KPYKCSE--CDKCFTQKCSLTIHQRIHTGEKPYKC--GKCEKCFTHKG 336
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390309 337 DLRSHQRI--HTGEKPYKCSECD--KCF-----THKRSLRSHQRIHTGEKPYKCSECDKCFTHKRSLSIHQIIHTEEKPY 407
Cdd:COG5048   368 NNEPPQSLqqYKDLKNDKKSETLsnSCIrnfkrDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                  ....*....
gi 1720390309 408 RCSGCDKIF 416
Cdd:COG5048   448 LCSILKSFR 456
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
347-425 2.63e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 2.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390309 347 GEKPYKCS--ECDKCFTHKRSLRSHqRIHtgekpykcSECDKCFTHKRSLSIHQIIHTEEKPYRCSGCDKIFNHKGDLRN 424
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416

                  .
gi 1720390309 425 H 425
Cdd:COG5189   417 H 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
291-369 1.46e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390309 291 GEKPYKCS--ECDKCFTQKCSLTIHqRIHtgekpykcGKCEKCFTHKGDLRSHQRIHTGEKPYKCSECDKCFTHKRSLRS 368
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416

                  .
gi 1720390309 369 H 369
Cdd:COG5189   417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
365-390 5.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.39e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720390309 365 SLRSHQRIHTGEKPYKCSECDKCFTH 390
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
337-362 5.55e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.55e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720390309 337 DLRSHQRIHTGEKPYKCSECDKCFTH 362
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
253-278 6.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720390309 253 DLRIHQRIHTGEKPYKCIECDKSFTQ 278
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
421-446 1.38e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.38e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390309 421 DLRNHQRIHTGQKPYKCSECDKCFVH 446
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
198-222 3.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.69e-03
                          10        20
                  ....*....|....*....|....*
gi 1720390309 198 LRQHQIIHTGEKPYRCSQCDKCFSQ 222
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-306 3.92e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.92e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720390309 281 HLIIHQRIHTGEKPYKCSECDKCFTQ 306
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-322 4.40e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 4.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390309 265 KPYKCIECDKSFTQKGHLIIHQRIHTGEKPYKCS--ECDKCFTQKCSLTIHQRIHTGEKP 322
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPS 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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