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Conserved domains on  [gi|1720355545|ref|XP_030110449|]
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opticin isoform X4 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
207-304 3.31e-10

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 3.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 207 KLRRIDLSGNSISSIhNDALRLLPALQDLILPENQLAALPV----LPSgIEFLDVRLNRLQSsgiQPEAFVALKKLQFLY 282
Cdd:COG4886   137 NLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEelgnLTN-LKELDLSNNQITD---LPEPLGNLTNLEELD 211

                          90       100
                  ....*....|....*....|....
gi 1720355545 283 LANNMLDSIPGPLPL--SLRSLHL 304
Cdd:COG4886   212 LSGNQLTDLPEPLANltNLETLDL 235
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
207-304 3.31e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 3.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 207 KLRRIDLSGNSISSIhNDALRLLPALQDLILPENQLAALPV----LPSgIEFLDVRLNRLQSsgiQPEAFVALKKLQFLY 282
Cdd:COG4886   137 NLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEelgnLTN-LKELDLSNNQITD---LPEPLGNLTNLEELD 211

                          90       100
                  ....*....|....*....|....
gi 1720355545 283 LANNMLDSIPGPLPL--SLRSLHL 304
Cdd:COG4886   212 LSGNQLTDLPEPLANltNLETLDL 235
LRR_8 pfam13855
Leucine rich repeat;
207-288 6.97e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 6.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 207 KLRRIDLSGNSISSIHNDALRLLPALQDLILPENQLaalpvlpsgiefldvrlnrlqsSGIQPEAFVALKKLQFLYLANN 286
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL----------------------TTLSPGAFSGLPSLRYLDLSGN 59


                  ..
gi 1720355545 287 ML 288
Cdd:pfam13855  60 RL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
158-310 1.28e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.08  E-value: 1.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 158 QIPEAKISNLT-LPTRTSptSTVAQKTLSPNLTMAVPTTTGllnsqsshAKLRRIDLSGNSISS-------------IHN 223
Cdd:PRK15370  244 QEMELSINRITeLPERLP--SALQSLDLFHNKISCLPENLP--------EELRYLSVYDNSIRTlpahlpsgithlnVQS 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 224 DALRLLPA-----LQDLILPENQLAALPV-LPSGIEFLDVRLNRLQssgIQPEAFVAlkKLQFLYLANNMLDSIPGPLPL 297
Cdd:PRK15370  314 NSLTALPEtlppgLKTLEAGENALTSLPAsLPPELQVLDVSKNQIT---VLPETLPP--TITTLDVSRNALTNLPENLPA 388

                         170
                  ....*....|...
gi 1720355545 298 SLRSLHLQYPLLA 310
Cdd:PRK15370  389 ALQIMQASRNNLV 401
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 207-305 9.68e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 9.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 207 KLRRIDLSGNSISSIHNdaLRLLPALQDLILpENQlaalpVLPSG--IEF--------------LDVRLNRLQSsgiqPE 270
Cdd:cd21340    69 NLKKLYLGGNRISVVEG--LENLTNLEELHI-ENQ-----RLPPGekLTFdprslaalsnslrvLNISGNNIDS----LE 136

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1720355545 271 AFVALKKLQFLYLANNMLDSIPGPLPL-----SLRSLHLQ 305
Cdd:cd21340   137 PLAPLRNLEQLDASNNQISDLEELLDLlsswpSLRELDLT 176
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
207-304 3.31e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 3.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 207 KLRRIDLSGNSISSIhNDALRLLPALQDLILPENQLAALPV----LPSgIEFLDVRLNRLQSsgiQPEAFVALKKLQFLY 282
Cdd:COG4886   137 NLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEelgnLTN-LKELDLSNNQITD---LPEPLGNLTNLEELD 211

                          90       100
                  ....*....|....*....|....
gi 1720355545 283 LANNMLDSIPGPLPL--SLRSLHL 304
Cdd:COG4886   212 LSGNQLTDLPEPLANltNLETLDL 235
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
207-306 2.61e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.02  E-value: 2.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 207 KLRRIDLSGNSISSIhNDALRLLPALQDLILPENQLAALPV----LPSgIEFLDVRLNRLQSsgiQPEAFVALKKLQFLY 282
Cdd:COG4886   160 NLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEplgnLTN-LEELDLSGNQLTD---LPEPLANLTNLETLD 234

                          90       100
                  ....*....|....*....|....*.
gi 1720355545 283 LANNMLDSIP--GPLPlSLRSLHLQY 306
Cdd:COG4886   235 LSNNQLTDLPelGNLT-NLEELDLSN 259
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
207-306 1.75e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 1.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 207 KLRRIDLSGNSISSIHnDALRLLPALQDLILPENQLAALPV----LPSgIEFLDVRLNRLQSsgiqPEAFVALKKLQFLY 282
Cdd:COG4886   183 NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEplanLTN-LETLDLSNNQLTD----LPELGNLTNLEELD 256

                          90       100
                  ....*....|....*....|....*
gi 1720355545 283 LANNMLDSIPGPLPL-SLRSLHLQY 306
Cdd:COG4886   257 LSNNQLTDLPPLANLtNLKTLDLSN 281
LRR_8 pfam13855
Leucine rich repeat;
207-288 6.97e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 6.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 207 KLRRIDLSGNSISSIHNDALRLLPALQDLILPENQLaalpvlpsgiefldvrlnrlqsSGIQPEAFVALKKLQFLYLANN 286
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL----------------------TTLSPGAFSGLPSLRYLDLSGN 59


                  ..
gi 1720355545 287 ML 288
Cdd:pfam13855  60 RL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
158-310 1.28e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.08  E-value: 1.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 158 QIPEAKISNLT-LPTRTSptSTVAQKTLSPNLTMAVPTTTGllnsqsshAKLRRIDLSGNSISS-------------IHN 223
Cdd:PRK15370  244 QEMELSINRITeLPERLP--SALQSLDLFHNKISCLPENLP--------EELRYLSVYDNSIRTlpahlpsgithlnVQS 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 224 DALRLLPA-----LQDLILPENQLAALPV-LPSGIEFLDVRLNRLQssgIQPEAFVAlkKLQFLYLANNMLDSIPGPLPL 297
Cdd:PRK15370  314 NSLTALPEtlppgLKTLEAGENALTSLPAsLPPELQVLDVSKNQIT---VLPETLPP--TITTLDVSRNALTNLPENLPA 388

                         170
                  ....*....|...
gi 1720355545 298 SLRSLHLQYPLLA 310
Cdd:PRK15370  389 ALQIMQASRNNLV 401
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
207-291 2.28e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 2.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 207 KLRRIDLSGNSISSIhNDALRLLPALQDLILPENQLAALPVLP--SGIEFLDVRLNRLqsSGIQPEAfvALKKLQFLYLA 284
Cdd:COG4886   206 NLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPELGnlTNLEELDLSNNQL--TDLPPLA--NLTNLKTLDLS 280


                  ....*..
gi 1720355545 285 NNMLDSI 291
Cdd:COG4886   281 NNQLTDL 287
LRR_8 pfam13855
Leucine rich repeat;
255-306 1.32e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 1.32e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720355545 255 LDVRLNRLQSsgIQPEAFVALKKLQFLYLANNMLDSIPG----PLPlSLRSLHLQY 306
Cdd:pfam13855   6 LDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPgafsGLP-SLRYLDLSG 58
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
117-306 9.20e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.69  E-value: 9.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 117 QSPEEGDTYASLYVGNHTLSIEDYNEVIDLSNYEELADYGDQIPEAKISNLTLPTRTSPTSTVAQKTLSPNLTMAVPTTT 196
Cdd:COG4886     7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 197 GLLNSQSSHAKLRRIDLSGNsissihnDALRLLPALQDLILPENQLAALPvlpsgiefldvrlnrlqssgiqpEAFVALK 276
Cdd:COG4886    87 LGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLP-----------------------EELANLT 136

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1720355545 277 KLQFLYLANNMLDSIPGPLPL--SLRSLHLQY 306
Cdd:COG4886   137 NLKELDLSNNQLTDLPEPLGNltNLKSLDLSN 168
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 207-305 9.68e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 9.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 207 KLRRIDLSGNSISSIHNdaLRLLPALQDLILpENQlaalpVLPSG--IEF--------------LDVRLNRLQSsgiqPE 270
Cdd:cd21340    69 NLKKLYLGGNRISVVEG--LENLTNLEELHI-ENQ-----RLPPGekLTFdprslaalsnslrvLNISGNNIDS----LE 136

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1720355545 271 AFVALKKLQFLYLANNMLDSIPGPLPL-----SLRSLHLQ 305
Cdd:cd21340   137 PLAPLRNLEQLDASNNQISDLEELLDLlsswpSLRELDLT 176
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
131-310 1.14e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.92  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 131 GNHTLSIEDYNEV----IDLSNYEELADYGDQiPEAKISNLTLPTRTSPTSTVAQKTLSPNLTMAVPTTTGLlNSQSSHA 206
Cdd:PRK15387  116 GNYTVNCQGYSEThrltLDTAQGEEGTGHAEG-ASGTFRTSFLPATTAPQTPAEYDAVWSAWRRAAPAEESR-GRAAVVQ 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 207 KLRRIDLSGNSISSIHNDALRLLP-----ALQDLILPENQLAALPVLPSGIEFLDVRLNRLQSSGIQPEAFVAL------ 275
Cdd:PRK15387  194 KMRACLNNGNAVLNVGESGLTTLPdclpaHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELsifsnp 273

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1720355545 276 --------KKLQFLYLANNMLDSIPgPLPLSLRSLHLQYPLLA 310
Cdd:PRK15387  274 lthlpalpSGLCKLWIFGNQLTSLP-VLPPGLQELSVSDNQLA 315
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
208-275 4.67e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 38.99  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 208 LRRIDLSGNSISSI------------HNDALRLLPAL----QDLILPENQLAALPVLPSGIEFLDVRLNRLQSSGIQPEA 271
Cdd:PRK15387  344 LQELSVSDNQLASLptlpselyklwaYNNRLTSLPALpsglKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLPSG 423


                  ....
gi 1720355545 272 FVAL 275
Cdd:PRK15387  424 LLSL 427
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
215-302 4.88e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 38.99  E-value: 4.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 215 GNSISSIHndalRLLPALQDLILPENQLAALPVLPSGIEFLDVRLNRLQSSGIQPEAfvalkkLQFLYLANNMLDSIPgP 294
Cdd:PRK15387  291 GNQLTSLP----VLPPGLQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPTLPSG------LQELSVSDNQLASLP-T 359


                  ....*...
gi 1720355545 295 LPLSLRSL 302
Cdd:PRK15387  360 LPSELYKL 367
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
208-302 5.56e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 38.60  E-value: 5.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720355545 208 LRRIDLSGNSISSI------------HNDALRLLP----ALQDLILPENQLAALPVLPSGIEFLDVRLNRLQSSGIQPEA 271
Cdd:PRK15387  304 LQELSVSDNQLASLpalpselcklwaYNNQLTSLPtlpsGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSG 383

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1720355545 272 fvalkkLQFLYLANNMLDSIPgPLPLSLRSL 302
Cdd:PRK15387  384 ------LKELIVSGNRLTSLP-VLPSELKEL 407
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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