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Conserved domains on  [gi|171988402|gb|ACB59412|]
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NADH dehydrogenase subunit 2, partial (mitochondrion) [Drosophila signata]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475933)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-163 2.04e-43

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 146.12  E-value: 2.04e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402   1 MFNNSSKILFLMMMFMGSLISITSNSWLGAWMGLEINLLSFIPLMSDSNNLKSTESSLKYFLTQALASAVLLFAVILLML 80
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402  81 KNNVNlelkNSFISMILLSTLLMKSGAAPFHFWFPNLMDGLTWLNSLLLMTWQKIAPLMLISYLNLNNLLIFSVILSVMT 160
Cdd:MTH00160  81 NLMLF----NNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAII 156


                 ...
gi 171988402 161 GAI 163
Cdd:MTH00160 157 GAI 159
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-163 2.04e-43

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 146.12  E-value: 2.04e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402   1 MFNNSSKILFLMMMFMGSLISITSNSWLGAWMGLEINLLSFIPLMSDSNNLKSTESSLKYFLTQALASAVLLFAVILLML 80
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402  81 KNNVNlelkNSFISMILLSTLLMKSGAAPFHFWFPNLMDGLTWLNSLLLMTWQKIAPLMLISYLNLNNLLIFSVILSVMT 160
Cdd:MTH00160  81 NLMLF----NNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAII 156


                 ...
gi 171988402 161 GAI 163
Cdd:MTH00160 157 GAI 159
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 24-141 7.45e-11

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 58.86  E-value: 7.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402   24 SNSWLGAWMGLEINLLSFIPLMSD-SNNLKSTESSLKYFLTQALASAVLLFAVI-------------LLMLKNNVNLELK 89
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYwGKSPRSSEAGMKYFLLTLLGSSILLFGISlmynytgtlsfdeLSKALTGGLNSSG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 171988402   90 NSFISMILLSTLLMKSGAAPFHFWFPNLMDGLTWLNSLLL-MTWQKIAPLMLI 141
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLaATLVKAGGYGLI 133
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 13-115 1.81e-06

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 46.26  E-value: 1.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402  13 MMFMGSlisitSNSWLGAWMGLEINLLSFIPLMS-DSNNLKSTESSLKYFLTQALASAVLLFAVILL----------MLK 81
Cdd:COG1007  115 MMLMAS-----ANDLLTLFLGLELLSLSLYVLVAfRRDDRRSSEAALKYFLLGALSSGFLLYGISLLygatgslnlaGIA 189

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 171988402  82 NNVNLELKNSFISMI----LLSTLLMKSGAAPFHFWFP 115
Cdd:COG1007  190 AALAAGGANSPLLLLglvlVLAGLAFKLSAVPFHMWTP 227
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 2-163 3.61e-05

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 42.63  E-value: 3.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402    2 FNNSSKILFLMMMFMGSLISITSNSWLGAWMGLEINLLSFIPLMSDS-NNLKSTESSLKYFLTQALASAVLLFAVILL-- 78
Cdd:TIGR01770  99 INKFEFYILLLFALLGIFLLVSSNDLLSIYLGLELQSLCFYVLAGLKrKSRFSTEAGLKYFILGAFSSGLLLFGISLIyg 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402   79 ---------MLKNNVNLELKNSFISM---ILLSTLLMKSGAAPFHFWFPNLMDGLTWLNSLLLMTWQKIAPLMLISYLNL 146
Cdd:TIGR01770 179 ftgslnfedLLLFLSNGMLNISLLLLgivLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFL 258

                         170
                  ....*....|....*..
gi 171988402  147 NNLLIFSVILSVMTGAI 163
Cdd:TIGR01770 259 YILFGFSEAWQIFLAII 275
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-163 2.04e-43

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 146.12  E-value: 2.04e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402   1 MFNNSSKILFLMMMFMGSLISITSNSWLGAWMGLEINLLSFIPLMSDSNNLKSTESSLKYFLTQALASAVLLFAVILLML 80
Cdd:MTH00160   1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402  81 KNNVNlelkNSFISMILLSTLLMKSGAAPFHFWFPNLMDGLTWLNSLLLMTWQKIAPLMLISYLNLNNLLIFSVILSVMT 160
Cdd:MTH00160  81 NLMLF----NNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLINNNFIIIIIILSAII 156


                 ...
gi 171988402 161 GAI 163
Cdd:MTH00160 157 GAI 159
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 8-162 2.49e-31

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 114.94  E-value: 2.49e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402   8 ILFLMMMFMGSLISITSNSWLGAWMGLEINLLSFIPLMSDSNNLKSTESSLKYFLTQALASAVLLFAVIL-LMLKNNVNL 86
Cdd:MTH00105   7 IIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIInLMYSGQWTI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402  87 -ELKNSFISMILLSTLLMKSGAAPFHFWFPNLMDGLTWLNSLLLMTWQKIAPLMLI----SYLNLnNLLIFSVILSVMTG 161
Cdd:MTH00105  87 tKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILyqisPSINP-NLLLTLAILSILIG 165


                 .
gi 171988402 162 A 162
Cdd:MTH00105 166 G 166
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 6-161 1.03e-30

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 113.38  E-value: 1.03e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402   6 SKILFLMMMFMGSLISITSNSWLGAWMGLEINLLSFIPLMSDSNNLKSTESSLKYFLTQALASAVLLFAVIL--LMLKNN 83
Cdd:MTH00112   5 AKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTnaWNTGQW 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402  84 VNLELKNSFISMILLSTLLMKSGAAPFHFWFPNLMDGLTWLNSLLLMTWQKIAP--LMLISYLNLN-NLLIFSVILSVMT 160
Cdd:MTH00112  85 DITQLTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPltLLLMTSNSLNpTLLLTLAILSTLI 164


                 .
gi 171988402 161 G 161
Cdd:MTH00112 165 G 165
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 5-163 7.71e-26

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 99.96  E-value: 7.71e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402   5 SSKILFLMMMFMGSLISITSNSWLGAWMGLEINLLSFIPLMSDSNNLKSTESSLKYFLTQALASAVLLFAVILLMLKNNV 84
Cdd:MTH00144   4 PSNLLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFS 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 171988402  85 nlelknSFISMILLSTLLMKSGAAPFHFWFPNLMDGLTWLNSLLLMTWQKIAPLMLISYLNLNNLLIFSVILSVMTGAI 163
Cdd:MTH00144  84 ------WFSMSLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLAYLLCVISVLSAL 156
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 3-163 4.48e-25

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 98.46  E-value: 4.48e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402   3 NNSSKILFLMMMFMGSLISITSNSWLGAWMGLEINLLSFIPLMSDSNNLKSTESSLKYFLTQALASAVLLFAVIL-LMLK 81
Cdd:MTH00041   2 NRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIqAWLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402  82 NNVNL-ELKNSFISMILLSTLLMKSGAAPFHFWFPNLMDGLTWLNSLLLMTWQKIAPLMLISYLN---LNNLLIFSVILS 157
Cdd:MTH00041  82 GSWSInGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISnllNSNILILCGILS 161


                 ....*.
gi 171988402 158 VMTGAI 163
Cdd:MTH00041 162 VLVGGW 167
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 9-161 7.83e-25

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 97.57  E-value: 7.83e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402   9 LFLMMMFMGSLISITSNSWLGAWMGLEINLLSFIPLMSDSNNLKSTESSLKYFLTQALASAVLLFAVIL---LMLKNNVN 85
Cdd:MTH00135   8 ILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTnawLTGQWDIQ 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 171988402  86 lELKNSFISMILLSTLLMKSGAAPFHFWFPNLMDGLTWLNSLLLMTWQKIAPLMLISYLNLNN--LLIFSVILSVMTG 161
Cdd:MTH00135  88 -QMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPTNptLLITLGLTSTLVG 164
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 10-161 7.99e-25

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 97.68  E-value: 7.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402  10 FLMMMFMGSLISITSNSWLGAWMGLEINLLSFIPLMSDSNNLKSTESSLKYFLTQALASAVLLFAVILLMLKNN--VNLE 87
Cdd:MTH00070   9 LLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWFTGewTIMN 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 171988402  88 LKNSFISMILLSTLLMKSGAAPFHFWFPNLMDGLTWLNSLLLMTWQKIAPLML---ISYLNLNNLLIFSVILSVMTG 161
Cdd:MTH00070  89 MQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALliqISHLLNSNLLIIMGLLSTLIG 165
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 9-159 3.36e-21

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 87.53  E-value: 3.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402   9 LFLMMMFMGSLISITSNSWLGAWMGLEINLLSFIPLMSDSNNLKSTESSLKYFLTQALASAVLLFAVILLMLKNNvnleL 88
Cdd:MTH00011  10 LFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMWSFPS----L 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 171988402  89 KNSFISMILLSTLLMKSGAAPFHFWFPNLMDGLTWLNSLLLMTWQKIAPLMLISYLNLNNLLIFSVILSVM 159
Cdd:MTH00011  86 LKNITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNILPMMTSMAAM 156
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 9-163 2.27e-20

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 85.79  E-value: 2.27e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402   9 LFLMMMFMGSLISITSNSWLGAWMGLEINLLSFIPLMSDSNNLKSTESSLKYFLTQALASAVLLFAVILLMLKNNVN--L 86
Cdd:MTH00200   8 LFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWTSGQWgiS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402  87 ELKNSFISMILLSTLLMKSGAAPFHFWFPNLMDGLTWLNSLLLMTWQKIAPLML---ISYLNLNNLLIFSVILSVMTGAI 163
Cdd:MTH00200  88 EMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALliqLAPALNSNILLLLGLLSVLVGGW 167
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 9-163 1.81e-19

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 82.80  E-value: 1.81e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402   9 LFLMMMFMGSLISITSNSWLGAWMGLEINLLSFIPLMSDSNNLKSTESSLKYFLTQALASAVLLFAVILLMLKNNVNLel 88
Cdd:MTH00197   2 LFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSFSNLYLSL-- 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 171988402  89 knsFISMILLSTLLMKSGAAPFHFWFPNLMDGLTWLNSLLLMTWQKIAPLMLISYLNLNNLLIF-SVILSVMTGAI 163
Cdd:MTH00197  80 ---LSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSSSFMGLLiCSVLSSLIGGI 152
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 5-163 1.83e-11

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 60.80  E-value: 1.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402   5 SSKILFLMMMFMGSLISITSNSWLGAWMGLEINLLS-FIPLMSDSNNLKSTESSLKYFLTQALASAVLLFAVILLM-LKN 82
Cdd:MTH00199  97 QSSPILILIVALGSLLLVSSINWLSIYLAIELQTLTlFILVALKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALLYgLTG 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402  83 NVNLELKNSF----ISMILLS-TLLMKSGAAPFHFWFPNLMDGLTWLNSLLLMTWQKIAPL-MLISYLNLNNLLIFSVIL 156
Cdd:MTH00199 177 ETSIQGINSIltgdVGKILITiSLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFsILVQIGPVTNVVLICAVL 256


                 ....*..
gi 171988402 157 SVMTGAI 163
Cdd:MTH00199 257 SIIYGAI 263
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 13-163 2.27e-11

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 60.43  E-value: 2.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402  13 MMFMGSLISITSNSWLGAWMGLEINLLS-FIPLMSDSNNLKSTESSLKYFLTQALASAVLLFAVILL------------- 78
Cdd:MTH00196   1 MVALGILCLISSSNWLSVYLAIELQTLSlFILIAQNRGSGYSAEAGLKYFVLGALSSGLFLFGCALLcgttgglhlsyin 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402  79 MLKNN--VNLELKNSFISMILLSTLLMKSGAAPFHFWFPNLMDGLTWLNSLLLMTWQKIAPLMLISYLNLN-NLLIFSVI 155
Cdd:MTH00196  81 LVLNSgqSFSSVSVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGLNvNILLIGGL 160


                 ....*...
gi 171988402 156 LSVMTGAI 163
Cdd:MTH00196 161 FSLFVGAI 168
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 24-141 7.45e-11

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 58.86  E-value: 7.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402   24 SNSWLGAWMGLEINLLSFIPLMSD-SNNLKSTESSLKYFLTQALASAVLLFAVI-------------LLMLKNNVNLELK 89
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYwGKSPRSSEAGMKYFLLTLLGSSILLFGISlmynytgtlsfdeLSKALTGGLNSSG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 171988402   90 NSFISMILLSTLLMKSGAAPFHFWFPNLMDGLTWLNSLLL-MTWQKIAPLMLI 141
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLaATLVKAGGYGLI 133
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 13-115 1.81e-06

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 46.26  E-value: 1.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402  13 MMFMGSlisitSNSWLGAWMGLEINLLSFIPLMS-DSNNLKSTESSLKYFLTQALASAVLLFAVILL----------MLK 81
Cdd:COG1007  115 MMLMAS-----ANDLLTLFLGLELLSLSLYVLVAfRRDDRRSSEAALKYFLLGALSSGFLLYGISLLygatgslnlaGIA 189

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 171988402  82 NNVNLELKNSFISMI----LLSTLLMKSGAAPFHFWFP 115
Cdd:COG1007  190 AALAAGGANSPLLLLglvlVLAGLAFKLSAVPFHMWTP 227
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 6-162 2.31e-06

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 46.39  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402   6 SKILFLMMMFMGSLISITSNSWLGAWMGLEINLLSFIPLMSDSNNLKST---------ESSLKYFLTQALASAVLLFA-- 74
Cdd:MTH00198 189 SGFALVLIVGLGGLLLIESANWLTIYLALEFQTLALFILAGEGSQPGSHfpspgntppESGLKYWILGAMSSGFYLFGca 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402  75 -------------VILLMLKNNVNLELKNSFISMILLS-TLLMKSGAAPFHFWFPNLMDGLTWLNSLLLMTWQKIAPLML 140
Cdd:MTH00198 269 lyfgftgnegmlgTILSATLETTNIELRQGSLGYLFITvAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYIL 348

                        170       180
                 ....*....|....*....|...
gi 171988402 141 ISYLNLNNLLIFSV-ILSVMTGA 162
Cdd:MTH00198 349 LTSLVITSKLLLSVaIISLVVGA 371
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
11-115 2.51e-06

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 45.97  E-value: 2.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402  11 LMMMFMGSLISITSNSWLGAWMGLEI-NLLSFIPLMSDSNNLKSTESSLKYFLTQALASAVLL--------------FAV 75
Cdd:PRK05777 109 VLFALLGMMVMVSANDLLTLFLGLELlSLPLYALAALRRDRRRSLEAAIKYFVLGALASGFLLygmsllygatgslsFAG 188

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 171988402  76 ILLMLKNNVNLELKNSFISMILLSTLLMKSGAAPFHFWFP 115
Cdd:PRK05777 189 IAKALADGSGNSLLLLFGLVFLLVGLAFKLSAVPFHMWTP 228
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 2-163 3.61e-05

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 42.63  E-value: 3.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402    2 FNNSSKILFLMMMFMGSLISITSNSWLGAWMGLEINLLSFIPLMSDS-NNLKSTESSLKYFLTQALASAVLLFAVILL-- 78
Cdd:TIGR01770  99 INKFEFYILLLFALLGIFLLVSSNDLLSIYLGLELQSLCFYVLAGLKrKSRFSTEAGLKYFILGAFSSGLLLFGISLIyg 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171988402   79 ---------MLKNNVNLELKNSFISM---ILLSTLLMKSGAAPFHFWFPNLMDGLTWLNSLLLMTWQKIAPLMLISYLNL 146
Cdd:TIGR01770 179 ftgslnfedLLLFLSNGMLNISLLLLgivLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFL 258

                         170
                  ....*....|....*..
gi 171988402  147 NNLLIFSVILSVMTGAI 163
Cdd:TIGR01770 259 YILFGFSEAWQIFLAII 275
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 55-116 2.27e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 40.47  E-value: 2.27e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 171988402  55 ESSLKYFLTQALASAVLLFAVILLMLKNN--------VNLELKNSFISMI----LLSTLLMKSGAAPFHFWFPN 116
Cdd:PRK08376 172 EAGIKYMFVGSLASSMVLLGIALLYGQYGtlnmaylaVKMSENPTVVAKIalalFIAGLAMKSGAVPVHMWLPD 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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