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Conserved domains on  [gi|1719379330|ref|WP_145680061|]
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DNA-directed RNA polymerase subunit beta [Azospirillum brasilense]

Protein Classification

DNA-directed RNA polymerase subunit beta( domain architecture ID 11478603)

DNA-directed RNA polymerase subunit beta catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
1-1392 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


:

Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2278.48  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330    1 MAKSFTGRKRVRKSFGRIPEVTQMPNLIEVQRSSYDHFLQMDVPPEkraNLGLQEVFRSVFPIKDFSDRAVLDFVKYELE 80
Cdd:PRK00405     1 MVYSYTGKKRIRKSFGKIKEVLELPNLLEIQLDSFDWFLQLDVPPE---DEGLEEVFRSIFPIEDFNGNLSLEFVSYELG 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   81 QPKYDVEECQQRGMTFAAPLKVTLRLsvfdVEEDTGlrsirDIKEQDVYMGDMPLMTANGTFIINGTERVIVSQMHRSPG 160
Cdd:PRK00405    78 EPKYDVEECKERGLTYSAPLRVKLRL----INKETG-----EIKEQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPG 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  161 VFFDHDKGKThSSGKYLFAARVIPYRGSWLDFEFDAKDLVYVRIDRRRKLPATTLLFALdgaetealraerkaqkkdllp 240
Cdd:PRK00405   149 VYFDHDKDKT-SSGKLLYSARIIPYRGSWLEFEFDPKDILYVRIDRRRKLPVTVLLRAL--------------------- 206
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  241 yeaqGMAKEEILNFFYDTITYTRasggwktpfnadrmkgvkvasdlvdaasgqvvaeagtkmtprlikklvegglaEQLV 320
Cdd:PRK00405   207 ----GYSDEEILDLFYEKEEFGK-----------------------------------------------------EIEV 229
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  321 STEELTGRYLAVDIINERTGEVLFEAGDElsasdldklekagvdelpvlaIDHLNVGAYIRNTMAADRNASREDALIDIY 400
Cdd:PRK00405   230 PVEYLLGKVLAEDIVDEETGEVLAEANDE---------------------ITEELDGPYIRNTLEKDPTSSREEALVEIY 288
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  401 RVMRPGEPPTLESAEALFAGLFFDSERYDLSAVGRVKMNARLNFQTEDSVRVLRKQDIMSILKVLVNLKDGRGEIDDIDH 480
Cdd:PRK00405   289 RRLRPGEPPTVEAARSLLENLFFDPKRYDLSKVGRYKLNKKLGLDEDEDVRVLTKEDIIATIKYLINLRNGKGEVDDIDH 368
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  481 LGNRRVRSVGELMENQYRVGLLRMERAIRERMSSVEIDTVMPHDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEITHK 560
Cdd:PRK00405   369 LGNRRVRSVGELLQNQFRIGLSRMERAVRERMSLQDLDTLTPQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHK 448
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  561 RRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNQYGFIESPYRKVRDSIVTDEVVYLS 640
Cdd:PRK00405   449 RRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNEYGFIETPYRKVVDGKVTDEIVYLT 528
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  641 AMEEGRYVVAQANAELDADNRFAADLVSCRQGGEYLMFRPEAIDLIDVSPKQLVSVAAALIPFLENDDANRALMGSNMQR 720
Cdd:PRK00405   529 ADEEDNYVIAQANAPLDEDGRFVDELVTARYKGEFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQR 608
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  721 QAVPLVKADAPLVGTGMEATVARDSGVTIVAKRKGIVDQIDATRIVVRAtDSSDATAPGVDIYNLLKFQRSNQNTCITQR 800
Cdd:PRK00405   609 QAVPLLRPEAPLVGTGMERRVARDSGAVVVAKRDGVVEYVDASRIVVRV-EELDPGEDGVDIYNLIKFQRSNQNTCINQR 687
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  801 PLVKVGDRVAAGDIIADGPSTELGELALGRNVLVAFMPWNGYNFEDSILINERIVKDDVFTSIHIEEFEVMARDTKLGQE 880
Cdd:PRK00405   688 PIVKVGDRVEKGDVLADGPSTDNGELALGQNVLVAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEARDTKLGPE 767
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  881 EITRDIPNVGEEALKNLDEAGIVYIGAEVRPGDILVGKVTPKGESPMTPEEKLLRAIFGEKASDVRDTSLRLPPGVAGTI 960
Cdd:PRK00405   768 EITRDIPNVSEEALRNLDESGIVRIGAEVKPGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVKDTSLRVPHGEEGTV 847
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  961 VEVRVFSRrgvdkderalaieraeieklakdrdderailersfytrlkevilgqtaqsgpkgmkagtvltdaelanltkg 1040
Cdd:PRK00405   848 IDVKVFTR------------------------------------------------------------------------ 855
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1041 qwrqisiadeqvmetveslgkvfddsiqalqnrfenkvekLQRGDELPPGVMKMVKVFVAVKRKLQPGDKMAGRHGNKGV 1120
Cdd:PRK00405   856 ----------------------------------------IEQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGV 895
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1121 VSRILPQEDMPYLEDGQPVDLVLNPLGVPSRMNIGQILETHLGWASAGLGKQigraidqyrlamkgrgdaaqtmdglrit 1200
Cdd:PRK00405   896 VSRILPVEDMPYLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAAKGLGIK---------------------------- 947
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1201 lkeaygqkvyddqiadmtegellelggnlrkgvpFATPVFDGAREEDICQQLEKAGLDRSGQVTLIDGRTGEAFDRKVTV 1280
Cdd:PRK00405   948 ----------------------------------FATPVFDGAKEEEIKELLEEAGLPEDGKTTLYDGRTGEPFDRPVTV 993
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1281 GYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVSGRTKVYEA 1360
Cdd:PRK00405   994 GYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKVYEA 1073
                         1370      1380      1390
                   ....*....|....*....|....*....|..
gi 1719379330 1361 IVRGDDNFEAGIPESFNVLVKELRSLGLNVEL 1392
Cdd:PRK00405  1074 IVKGENIPEPGIPESFNVLVKELQSLGLDVEL 1105
 
Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
1-1392 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2278.48  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330    1 MAKSFTGRKRVRKSFGRIPEVTQMPNLIEVQRSSYDHFLQMDVPPEkraNLGLQEVFRSVFPIKDFSDRAVLDFVKYELE 80
Cdd:PRK00405     1 MVYSYTGKKRIRKSFGKIKEVLELPNLLEIQLDSFDWFLQLDVPPE---DEGLEEVFRSIFPIEDFNGNLSLEFVSYELG 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   81 QPKYDVEECQQRGMTFAAPLKVTLRLsvfdVEEDTGlrsirDIKEQDVYMGDMPLMTANGTFIINGTERVIVSQMHRSPG 160
Cdd:PRK00405    78 EPKYDVEECKERGLTYSAPLRVKLRL----INKETG-----EIKEQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPG 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  161 VFFDHDKGKThSSGKYLFAARVIPYRGSWLDFEFDAKDLVYVRIDRRRKLPATTLLFALdgaetealraerkaqkkdllp 240
Cdd:PRK00405   149 VYFDHDKDKT-SSGKLLYSARIIPYRGSWLEFEFDPKDILYVRIDRRRKLPVTVLLRAL--------------------- 206
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  241 yeaqGMAKEEILNFFYDTITYTRasggwktpfnadrmkgvkvasdlvdaasgqvvaeagtkmtprlikklvegglaEQLV 320
Cdd:PRK00405   207 ----GYSDEEILDLFYEKEEFGK-----------------------------------------------------EIEV 229
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  321 STEELTGRYLAVDIINERTGEVLFEAGDElsasdldklekagvdelpvlaIDHLNVGAYIRNTMAADRNASREDALIDIY 400
Cdd:PRK00405   230 PVEYLLGKVLAEDIVDEETGEVLAEANDE---------------------ITEELDGPYIRNTLEKDPTSSREEALVEIY 288
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  401 RVMRPGEPPTLESAEALFAGLFFDSERYDLSAVGRVKMNARLNFQTEDSVRVLRKQDIMSILKVLVNLKDGRGEIDDIDH 480
Cdd:PRK00405   289 RRLRPGEPPTVEAARSLLENLFFDPKRYDLSKVGRYKLNKKLGLDEDEDVRVLTKEDIIATIKYLINLRNGKGEVDDIDH 368
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  481 LGNRRVRSVGELMENQYRVGLLRMERAIRERMSSVEIDTVMPHDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEITHK 560
Cdd:PRK00405   369 LGNRRVRSVGELLQNQFRIGLSRMERAVRERMSLQDLDTLTPQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHK 448
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  561 RRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNQYGFIESPYRKVRDSIVTDEVVYLS 640
Cdd:PRK00405   449 RRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNEYGFIETPYRKVVDGKVTDEIVYLT 528
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  641 AMEEGRYVVAQANAELDADNRFAADLVSCRQGGEYLMFRPEAIDLIDVSPKQLVSVAAALIPFLENDDANRALMGSNMQR 720
Cdd:PRK00405   529 ADEEDNYVIAQANAPLDEDGRFVDELVTARYKGEFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQR 608
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  721 QAVPLVKADAPLVGTGMEATVARDSGVTIVAKRKGIVDQIDATRIVVRAtDSSDATAPGVDIYNLLKFQRSNQNTCITQR 800
Cdd:PRK00405   609 QAVPLLRPEAPLVGTGMERRVARDSGAVVVAKRDGVVEYVDASRIVVRV-EELDPGEDGVDIYNLIKFQRSNQNTCINQR 687
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  801 PLVKVGDRVAAGDIIADGPSTELGELALGRNVLVAFMPWNGYNFEDSILINERIVKDDVFTSIHIEEFEVMARDTKLGQE 880
Cdd:PRK00405   688 PIVKVGDRVEKGDVLADGPSTDNGELALGQNVLVAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEARDTKLGPE 767
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  881 EITRDIPNVGEEALKNLDEAGIVYIGAEVRPGDILVGKVTPKGESPMTPEEKLLRAIFGEKASDVRDTSLRLPPGVAGTI 960
Cdd:PRK00405   768 EITRDIPNVSEEALRNLDESGIVRIGAEVKPGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVKDTSLRVPHGEEGTV 847
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  961 VEVRVFSRrgvdkderalaieraeieklakdrdderailersfytrlkevilgqtaqsgpkgmkagtvltdaelanltkg 1040
Cdd:PRK00405   848 IDVKVFTR------------------------------------------------------------------------ 855
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1041 qwrqisiadeqvmetveslgkvfddsiqalqnrfenkvekLQRGDELPPGVMKMVKVFVAVKRKLQPGDKMAGRHGNKGV 1120
Cdd:PRK00405   856 ----------------------------------------IEQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGV 895
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1121 VSRILPQEDMPYLEDGQPVDLVLNPLGVPSRMNIGQILETHLGWASAGLGKQigraidqyrlamkgrgdaaqtmdglrit 1200
Cdd:PRK00405   896 VSRILPVEDMPYLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAAKGLGIK---------------------------- 947
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1201 lkeaygqkvyddqiadmtegellelggnlrkgvpFATPVFDGAREEDICQQLEKAGLDRSGQVTLIDGRTGEAFDRKVTV 1280
Cdd:PRK00405   948 ----------------------------------FATPVFDGAKEEEIKELLEEAGLPEDGKTTLYDGRTGEPFDRPVTV 993
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1281 GYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVSGRTKVYEA 1360
Cdd:PRK00405   994 GYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKVYEA 1073
                         1370      1380      1390
                   ....*....|....*....|....*....|..
gi 1719379330 1361 IVRGDDNFEAGIPESFNVLVKELRSLGLNVEL 1392
Cdd:PRK00405  1074 IVKGENIPEPGIPESFNVLVKELQSLGLDVEL 1105
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
8-1392 0e+00

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 1888.60  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330    8 RKRVRKSFGRIPEVTQMPNLIEVQRSSYDHFLQMDVPPEKRANLGLQEVFRSVFPIKDFSDRAVLDFVKYELEQPKYDVE 87
Cdd:TIGR02013    1 KKRIRIDFGKIPEVLEVPNLLEIQLDSYDWFLQQDTPPEKRKEEGLEEVFKSIFPIEDYTGNIELEYLSYRLGEPKYSVE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   88 ECQQRGMTFAAPLKVTLRLSVFDvEEDTGlrsirDIKEQDVYMGDMPLMTANGTFIINGTERVIVSQMHRSPGVFFDHDK 167
Cdd:TIGR02013   81 ECKERGLTYSAPLKVKLRLINKE-EDGTK-----EIKEQDVYMGDIPLMTDRGTFIINGAERVVVSQLHRSPGVFFSSEK 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  168 GkTHSSGKYLFAARVIPYRGSWLDFEFDAKDLVYVRIDRRRKLPATTLLFALDgaetealraerkaqkkdllpyeaqgma 247
Cdd:TIGR02013  155 D-TTKSGKVLFSARIIPYRGSWLEFETDKKDVLYVRIDRKRKLPATVLLRALG--------------------------- 206
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  248 keeilnFFYDTitytrasggwktpfnadrmkgvkvasdlvdaasgqvvaeagtkmtprlikklvegglaeqlvsteeltg 327
Cdd:TIGR02013  207 ------YTIDT--------------------------------------------------------------------- 211
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  328 rylavdiinertgevlfeagdelsasdldklekagvdelpvLAIDHLNVGAYIRNTMAADRNASREDALIDIYRVMRPGE 407
Cdd:TIGR02013  212 -----------------------------------------LILNRLGSGEYIRNTLRKDPTNSEEEALVEIYRKLRPGE 250
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  408 PPTLESAEALFAGLFFDSERYDLSAVGRVKMNARLNFQTEDSVRVLRKQDIMSILKVLVNLKDGRGEIDDIDHLGNRRVR 487
Cdd:TIGR02013  251 PPTVEAARSLLENLFFDPKRYDLGRVGRYKLNKKLGLDVPESIGVLTKEDIIATIKYLIKLRNGKGEIDDIDHLGNRRIR 330
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  488 SVGELMENQYRVGLLRMERAIRERMSSVEIDTVMPHDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEITHKRRLSALG 567
Cdd:TIGR02013  331 SVGELLQNQFRVGLARMERIVRERMSTQDTDTLTPQDLINAKPISAAIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALG 410
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  568 PGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNQYGFIESPYRKVRDSIV--TDEVVYLSAMEEG 645
Cdd:TIGR02013  411 PGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLSTYARVNEYGFIETPYRKVKDGKVvvTDEIDYLTADEED 490
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  646 RYVVAQANAELDADNRFAADLVSCRQGGEYLMFRPEAIDLIDVSPKQLVSVAAALIPFLENDDANRALMGSNMQRQAVPL 725
Cdd:TIGR02013  491 NYVIAQANAPLDENGRFVEDLVVARYRGEITLVSPDQVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPL 570
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  726 VKADAPLVGTGMEATVARDSGVTIVAKRKGIVDQIDATRIVVRATDSSDATAPGVDIYNLLKFQRSNQNTCITQRPLVKV 805
Cdd:TIGR02013  571 LRSEAPLVGTGMEAKVARDSGAVIVAKRGGVVEYVDAKRIVIRYDEDEEEPDGGIDIYRLLKYQRSNQDTCINQRPIVSV 650
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  806 GDRVAAGDIIADGPSTELGELALGRNVLVAFMPWNGYNFEDSILINERIVKDDVFTSIHIEEFEVMARDTKLGQEEITRD 885
Cdd:TIGR02013  651 GDRVEAGDVLADGPSTDLGELALGRNVLVAFMPWNGYNYEDAILISERLVKDDVFTSIHIEEYEVEARDTKLGPEEITRD 730
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  886 IPNVGEEALKNLDEAGIVYIGAEVRPGDILVGKVTPKGESPMTPEEKLLRAIFGEKASDVRDTSLRLPPGVAGTIVEVRV 965
Cdd:TIGR02013  731 IPNVSEEALRNLDENGIVRIGAEVKAGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVRDTSLRVPPGVEGTVIDVKV 810
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  966 FSRrgvdkderalaieraeieklakdrdderailersfytrlkevilgqtaqsgpkgmkagtvltdaelanltkgqwrqi 1045
Cdd:TIGR02013  811 FSR----------------------------------------------------------------------------- 813
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1046 siadeqvmetveslgkvfddsiqalqnrfenkveklQRGDELPPGVMKMVKVFVAVKRKLQPGDKMAGRHGNKGVVSRIL 1125
Cdd:TIGR02013  814 ------------------------------------EQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSKIL 857
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1126 PQEDMPYLEDGQPVDLVLNPLGVPSRMNIGQILETHLGWASAGLGKqigraidqyrlamkgrgdaaqtmdglritlkeay 1205
Cdd:TIGR02013  858 PIEDMPFLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAGKRLGR---------------------------------- 903
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1206 gqkvyddqiadmtegellelggnlrKGVPFATPVFDGAREEDICQQLEKAGLDRSGQVTLIDGRTGEAFDRKVTVGYIYM 1285
Cdd:TIGR02013  904 -------------------------KGVPIATPVFDGASEEEIKEYLEKAGLPRDGKVRLYDGRTGEQFDRPVTVGYMYM 958
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1286 LKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVSGRTKVYEAIVRGD 1365
Cdd:TIGR02013  959 LKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKAYEAIVKGE 1038
                         1370      1380
                   ....*....|....*....|....*..
gi 1719379330 1366 DNFEAGIPESFNVLVKELRSLGLNVEL 1392
Cdd:TIGR02013 1039 NVPEPGIPESFNVLIKELQSLGLDIEL 1065
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
12-1392 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 1705.31  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   12 RKSFGRIPEVTQMPNLIEVQRSSYDHFLqmdvppekraNLGLQEVFRSVFPIKDFSDRAVLDFVKYELEQPKYDVEECQQ 91
Cdd:COG0085      1 RWSFAKIKEPLELPNLLEIQLDSFNWFL----------EEGLQEIFDEISPIEDFTGNLSLEFGDYRLGEPKYTPEECKE 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   92 RGMTFAAPLKVTLRLsvfdVEEDTGlrsirDIKEQDVYMGDMPLMTANGTFIINGTERVIVSQMHRSPGVFFDHDKGKth 171
Cdd:COG0085     71 RDLTYAAPLYVKVRL----VNKETG-----EIKEQEVFMGDFPLMTDSGTFIINGTERVIVSQLVRSPGVYFVEEEDK-- 139
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  172 sSGKYLFAARVIPYRGSWLDFEFDAKDLVYVRIDRRRKLPATTLLFALdGAETEalraerkaqkkdllpyeaqgmakEEI 251
Cdd:COG0085    140 -SGKDLYSAKVIPSRGAWLEFETDKDGTIYVRIDRKRKIPVTVLLRAL-GLETD-----------------------EEI 194
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  252 LNFFYDtitytrasggwktpfnadrmkgvkvasdlvdaasgqvvaeagtkmtprlikklvegglaeqlvsteeltgryla 331
Cdd:COG0085    195 LEAFGD-------------------------------------------------------------------------- 200
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  332 vDIINErtgevlfeagdelsasdldklekagvdelpvlaidhlnvgaYIRNTMAADRNASREDALIDIYRVMRPGEPPTL 411
Cdd:COG0085    201 -DPIQE-----------------------------------------YILATLEKDNTKTQEEALLEIYRKLRPGEPPTI 238
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  412 ESAEALFAGLFFDSERYDLSAVGRVKMNARLNFQTEDSVRVLRKQDIMSILKVLVNLKDGRGEIDDIDHLGNRRVRSVGE 491
Cdd:COG0085    239 ERAEQLLDNLFFDPKRYDLAHVGRYKINKKLGLDVPPEDRVLTAEDIVATIKYLLELHLGEREPDDIDHLGNRRVRLVGE 318
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  492 LMENQYRVGLLRMERAIRERMSSVEIDTVMPHDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEITHKRRLSALGPGGL 571
Cdd:COG0085    319 LLQNQFRVGLSRMERVVRERMTTQDVEAITPQSLINIRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGL 398
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  572 TRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNQYGFIESPYRKVRDSIVTDEVVYLSAMEEGRYVVAQ 651
Cdd:COG0085    399 SRERAGFEVRDVHPSHYGRMCPIETPEGPNIGLIGSLALYARVNEYGFIETPYRKVENGKVTDEIEYLTADEEENYYIAQ 478
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  652 ANAELDADNRFAADLVSCRQGGEYLMFRPEAIDLIDVSPKQLVSVAAALIPFLENDDANRALMGSNMQRQAVPLVKADAP 731
Cdd:COG0085    479 ANAPLDEDGNFLEERVLVRYRGEEVLVPPEEVDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPEAP 558
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  732 LvgtgmeatvardsgvtivakrkgivdqidatrivvratdssdatapgvDIYNLLKFQRSNQNTCITQRPLVKVGDRVAA 811
Cdd:COG0085    559 L------------------------------------------------LHYPLQKFQRSNQGTCINQRPIVRVGDRVEK 590
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  812 GDIIADGPSTELGELALGRNVLVAFMPWNGYNFEDSILINERIVKDDVFTSIHIEEFEVMARDTKLGQEEITRDIPNVGE 891
Cdd:COG0085    591 GDVLADGPATDNGELALGQNLLVAFMPWEGYNYEDAIIISERLVKDDVLTSIHIEEYEIEARDTKLGPEEITRDIPNVSE 670
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  892 EALKNLDEAGIVYIGAEVRPGDILVGKVTPKGESPMTPEEKLLRAIFGEKASDVRDTSLRLPPGVAGTIVEVRVFSRrgv 971
Cdd:COG0085    671 EALRNLDEDGIIRIGAEVKGGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLRVPHGEKGKVIDVKVFSR--- 747
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  972 dkderalaieraeieklakdrdderailersfytrlkevilgqtaqsgpkgmkagtvltdaelanltkgqwrqisiadeq 1051
Cdd:COG0085        --------------------------------------------------------------------------------
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1052 vmetveslgkvfddsiqalqnrfENkveklqrGDELPPGVMKMVKVFVAVKRKLQPGDKMAGRHGNKGVVSRILPQEDMP 1131
Cdd:COG0085    748 -----------------------EE-------GDELPPGVNKLVRVYVAQKRKIEVGDKLAGRHGNKGVISRILPQEDMP 797
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1132 YLEDGQPVDLVLNPLGVPSRMNIGQILETHLGWASAGLGKQIgraidqyrlamkgrgdaaqtmdglritlkeaygqkvyd 1211
Cdd:COG0085    798 FLEDGTPVDIVLNPLGVPSRMNVGQVLETHLGWAAALLGRRV-------------------------------------- 839
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1212 dqiadmtegellelggnlrkgvpfATPVFDGAREEDICQQLEKAGLDRSGQVTLIDGRTGEAFDRKVTVGYIYMLKLHHL 1291
Cdd:COG0085    840 ------------------------ATPVFDGAPEEEIRELLEKAGLPPDGKEVLYDGRTGEPFDNPVTVGYMYYLKLHHM 895
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1292 VDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVSGRTKVYEAIVRGDDNFEAG 1371
Cdd:COG0085    896 VDDKIHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQERLTIKSDDVCGRVKVYEAIVKGENIPEPG 975
                         1370      1380
                   ....*....|....*....|.
gi 1719379330 1372 IPESFNVLVKELRSLGLNVEL 1392
Cdd:COG0085    976 IPESFKVLLKELQSLGLDVEV 996
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
27-1393 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 863.42  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   27 LIEVQRSSYDHFLQMdvppekranlGLQEVFRSVFPIKDFSD--RAVLDFVKYELEQP---------KYDVEECQQRGMT 95
Cdd:cd00653      1 LVKQQIDSFNYFLNV----------GLQEIVKSIPPITDTDDdgRLKLKFGDIYLGKPkveeggvtrKLTPNECRLRDLT 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   96 FAAPLKVTLRLSVFDveedtglrsIRDIKEQDVYMGDMPLMTANGTFIING---TERVIVSQMHRSPGVFFdhdkgkths 172
Cdd:cd00653     71 YSAPLYVDIRLTVND---------KGKIKEQEVFIGEIPIMLRSKLCNLNGltpEELIKLGECPLDPGGYF--------- 132
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  173 sgkylfaarVIpyRGSwldfEfdaKDLVYVrIDRRRklpattllfaldgaetealraerkaqkkdllpyeaqgmakeeil 252
Cdd:cd00653    133 ---------II--NGT----E---KVIINQ-EQRSP-------------------------------------------- 149
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  253 NFFYdtitytrasggwktpfnADRMKGVKVASdlvdaasgqvvaeagtkmtprlikklvegglaeqlvsteeltgrylaV 332
Cdd:cd00653    150 NVII-----------------VEDSKGKRIYT-----------------------------------------------K 165
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  333 DIINERTGEvlfeAGDELSASDLDKlekagvdelpvlaIDHLNVGAYIRNtmaadrnasREDALIDIYRVMRpgepptle 412
Cdd:cd00653    166 TSIPSYSPY----RGSWLEVKSDKK-------------KDRIYVRIDLKR---------QEEALKYIGKRFE-------- 211
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  413 saealfaglffdserydlsavgrvkmnarlnfqtedsvrvlrkqDIMSILKVLVNLKDGRGEIDDIDHLGNRRVRSVGEL 492
Cdd:cd00653    212 --------------------------------------------DLIYMIRKLILLVLGKGKLDDIDHLGNKRVRLAGEL 247
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  493 MENQYRVGLLRMERAIRERMSSVEI--DTVMPHDLINAKPAAAAVREFFGSSQ------------LSQFMDQTNPLSEIT 558
Cdd:cd00653    248 LQNLFRSGLKRLEREVKEKLQKQLSkkKDLTPQLLINSKPITSGIKEFLATGNwgskrflmqrsgLSQVLDRLNPLSELS 327
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  559 HKRRLSAlgpGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNqyGFIESPYRKVRDSIvtdevvy 638
Cdd:cd00653    328 HKRRISS---LGLFRERKGFEVRDLHPSHWGRICPIETPEGENCGLVKNLALMARIS--GRIERPYRIVEKEV------- 395
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  639 lsameegryvvaqanaeldadnrfaadlvscrqggeylmfrpeaiDLIDVSPKQLVSVAAALIPFLENDDANRALMGSNM 718
Cdd:cd00653    396 ---------------------------------------------THIEISPSQILSVAASLIPFPEHNQSPRNLYQSNM 430
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  719 QRQAVPlvkadaplvgtgmeatvardsgvtivakrkgivdqIDATRIVVRaTDSSdatapgvdIYNLLKfqrsnqntciT 798
Cdd:cd00653    431 QKQAVG-----------------------------------TPALNQQYR-MDTK--------LYLLLY----------P 456
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  799 QRPLVKVGDRvaagDIIAdgpsteLGELALGRNVLVAFMPWNGYNFEDSILINERIVKDDVFTSIHIEEFEVMARDTKLG 878
Cdd:cd00653    457 QKPLVGTGIE----EYIA------FGELPLGQNAIVAVMSYSGYNFEDAIIINKSSVDRGFFRSIHYKKYEIELRKTKNG 526
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  879 QEEITR-DIPNVGEEALKNLDEAGIVYIGAEVRPGDILVGKVTPKGESPMTPeekllraIFGEKASDVRDTSLRLPPGVA 957
Cdd:cd00653    527 PEEITRgDIPNVSEEKLKNLDEDGIIRPGARVEPGDILVGKITPKGETESTP-------IFGEKARDVRDTSLKYPGGEK 599
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  958 GTIVEVRVFSRrgvdkderalaieraeieklakdrdderailersfytrlkevilgqtaqsgpkgmkagtvltdaelanl 1037
Cdd:cd00653    600 GIVDDVKIFSR--------------------------------------------------------------------- 610
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1038 tkgqwrqisiadeqvmetveslgkvfddsiqalqnrfenkveklqrgdELPPGVMKMVKVFVAVKRKLQPGDKMAGRHGN 1117
Cdd:cd00653    611 ------------------------------------------------ELNDGGNKLVKVYIRQKRKPQIGDKFASRHGQ 642
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1118 KGVVSRILPQEDMPYLEDGQPVDLVLNPLGVPSRMNIGQILETHLGWASAGLGKQIgraidqyrlamkgrgdaaqtmdgl 1197
Cdd:cd00653    643 KGVISKILPQEDMPFTEDGIPPDIILNPHGFPSRMTIGQLLESLLGKAGALLGKFG------------------------ 698
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1198 ritlkeaygqkvyddqiadmtegellelggnlrkgvpFATPvFDGAREEDICQQLEKAGLDRSGQVTLIDGRTGEAFDRK 1277
Cdd:cd00653    699 -------------------------------------DATP-FDGAEEEDISELLGEAGLNYYGKEVLYDGRTGEPLEAP 740
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1278 VTVGYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVSGRTKV 1357
Cdd:cd00653    741 IFVGPVYYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQRFGEMERDALIAHGAAYLLQERLTIKSDDVVARVCV 820
                         1370      1380      1390      1400
                   ....*....|....*....|....*....|....*....|....*.
gi 1719379330 1358 YEAIV----------RGDDNFEAGIPESFNVLVKELRSLGLNVELN 1393
Cdd:cd00653    821 KCGIIlsanlcrlckKGTNISKVGIPYAFKLLFQELQSMNIDPRLK 866
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
750-1317 3.84e-177

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 530.56  E-value: 3.84e-177
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  750 VAKRKGIVDQIDATRIVVRATDSSDAtapgVDIYNLLKFQRSNQNT---CITQRPLVKVGdRVAAGDiiadgpsteLGEL 826
Cdd:pfam00562    1 VASLIPFVDHNQSPRNTYQCAMGKQA----MGIYTLNKFYRSDQNTyvlCYPQKPLVKTG-AVEAGG---------FGEL 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  827 ALGRNVLVAFMPWNGYNFEDSILINERIVKDDVFTSIHIEEFEvmARDTKLGQ-EEITRDIPNVGEEALKNLDEAGIVYI 905
Cdd:pfam00562   67 PLGQNAIVAVMSYTGYNQEDAIIINKSSVDRGFFTSIHIKEIE--ARKTKLGPiEEITRDIPNVSEEALKKLDEDGIVRV 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  906 GAEVRPGDILVGKVTPkgespmTPEEKLLRAIFGEKASDVRDTSLRLPPGVAGTIVEVRVFsrrgvdkderalaieraei 985
Cdd:pfam00562  145 GAEVKPGDILVGKVGP------TELTKLLRAIFGEKARDVKDTSLKVPPGEEGVVDDVIVF------------------- 199
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  986 eklakdrdderailersfytrlkevilgqtaqsgpkgmkagtvltdaelanltkgqwrqisiadeqvmetveslgkvfdd 1065
Cdd:pfam00562      --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1066 siqalqnrfenkveklqrgdELPPGVMKMVKVFVAVKRKLQPGDKMAGRHGNKGVVSRILPQEDMPYLEDGQPVDLVLNP 1145
Cdd:pfam00562  200 --------------------ELPPGGIKMVKVYIRQKRKPEVGDKFASRHGQKGVVSRILPQEDMPFTEDGIPPDIILNP 259
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1146 LGVPSRMNIGQILETHLGWASAGlgkqigraidqyrlamkgrgdaaqtmdglritlkeaygqkvyddqiadmtegellel 1225
Cdd:pfam00562  260 HGVPSRMTIGQLLETHLGKAAAL--------------------------------------------------------- 282
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1226 ggnlrKGVPFATPVFDGARE--EDICQQLEKAGLDRSGQVTLIDGRTGEAFDRKVTVGYIYMLKLHHLVDDKIHARSIGP 1303
Cdd:pfam00562  283 -----LGVFVDATPFDGASTevEDIGELLEKAGYNYYGKEVLYDGRTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGP 357
                          570
                   ....*....|....
gi 1719379330 1304 YSLVTQQPLGGKAQ 1317
Cdd:pfam00562  358 YSLLTRQPLGGRAR 371
 
Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
1-1392 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2278.48  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330    1 MAKSFTGRKRVRKSFGRIPEVTQMPNLIEVQRSSYDHFLQMDVPPEkraNLGLQEVFRSVFPIKDFSDRAVLDFVKYELE 80
Cdd:PRK00405     1 MVYSYTGKKRIRKSFGKIKEVLELPNLLEIQLDSFDWFLQLDVPPE---DEGLEEVFRSIFPIEDFNGNLSLEFVSYELG 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   81 QPKYDVEECQQRGMTFAAPLKVTLRLsvfdVEEDTGlrsirDIKEQDVYMGDMPLMTANGTFIINGTERVIVSQMHRSPG 160
Cdd:PRK00405    78 EPKYDVEECKERGLTYSAPLRVKLRL----INKETG-----EIKEQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPG 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  161 VFFDHDKGKThSSGKYLFAARVIPYRGSWLDFEFDAKDLVYVRIDRRRKLPATTLLFALdgaetealraerkaqkkdllp 240
Cdd:PRK00405   149 VYFDHDKDKT-SSGKLLYSARIIPYRGSWLEFEFDPKDILYVRIDRRRKLPVTVLLRAL--------------------- 206
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  241 yeaqGMAKEEILNFFYDTITYTRasggwktpfnadrmkgvkvasdlvdaasgqvvaeagtkmtprlikklvegglaEQLV 320
Cdd:PRK00405   207 ----GYSDEEILDLFYEKEEFGK-----------------------------------------------------EIEV 229
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  321 STEELTGRYLAVDIINERTGEVLFEAGDElsasdldklekagvdelpvlaIDHLNVGAYIRNTMAADRNASREDALIDIY 400
Cdd:PRK00405   230 PVEYLLGKVLAEDIVDEETGEVLAEANDE---------------------ITEELDGPYIRNTLEKDPTSSREEALVEIY 288
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  401 RVMRPGEPPTLESAEALFAGLFFDSERYDLSAVGRVKMNARLNFQTEDSVRVLRKQDIMSILKVLVNLKDGRGEIDDIDH 480
Cdd:PRK00405   289 RRLRPGEPPTVEAARSLLENLFFDPKRYDLSKVGRYKLNKKLGLDEDEDVRVLTKEDIIATIKYLINLRNGKGEVDDIDH 368
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  481 LGNRRVRSVGELMENQYRVGLLRMERAIRERMSSVEIDTVMPHDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEITHK 560
Cdd:PRK00405   369 LGNRRVRSVGELLQNQFRIGLSRMERAVRERMSLQDLDTLTPQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHK 448
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  561 RRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNQYGFIESPYRKVRDSIVTDEVVYLS 640
Cdd:PRK00405   449 RRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNEYGFIETPYRKVVDGKVTDEIVYLT 528
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  641 AMEEGRYVVAQANAELDADNRFAADLVSCRQGGEYLMFRPEAIDLIDVSPKQLVSVAAALIPFLENDDANRALMGSNMQR 720
Cdd:PRK00405   529 ADEEDNYVIAQANAPLDEDGRFVDELVTARYKGEFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQR 608
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  721 QAVPLVKADAPLVGTGMEATVARDSGVTIVAKRKGIVDQIDATRIVVRAtDSSDATAPGVDIYNLLKFQRSNQNTCITQR 800
Cdd:PRK00405   609 QAVPLLRPEAPLVGTGMERRVARDSGAVVVAKRDGVVEYVDASRIVVRV-EELDPGEDGVDIYNLIKFQRSNQNTCINQR 687
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  801 PLVKVGDRVAAGDIIADGPSTELGELALGRNVLVAFMPWNGYNFEDSILINERIVKDDVFTSIHIEEFEVMARDTKLGQE 880
Cdd:PRK00405   688 PIVKVGDRVEKGDVLADGPSTDNGELALGQNVLVAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEARDTKLGPE 767
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  881 EITRDIPNVGEEALKNLDEAGIVYIGAEVRPGDILVGKVTPKGESPMTPEEKLLRAIFGEKASDVRDTSLRLPPGVAGTI 960
Cdd:PRK00405   768 EITRDIPNVSEEALRNLDESGIVRIGAEVKPGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVKDTSLRVPHGEEGTV 847
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  961 VEVRVFSRrgvdkderalaieraeieklakdrdderailersfytrlkevilgqtaqsgpkgmkagtvltdaelanltkg 1040
Cdd:PRK00405   848 IDVKVFTR------------------------------------------------------------------------ 855
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1041 qwrqisiadeqvmetveslgkvfddsiqalqnrfenkvekLQRGDELPPGVMKMVKVFVAVKRKLQPGDKMAGRHGNKGV 1120
Cdd:PRK00405   856 ----------------------------------------IEQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGV 895
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1121 VSRILPQEDMPYLEDGQPVDLVLNPLGVPSRMNIGQILETHLGWASAGLGKQigraidqyrlamkgrgdaaqtmdglrit 1200
Cdd:PRK00405   896 VSRILPVEDMPYLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAAKGLGIK---------------------------- 947
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1201 lkeaygqkvyddqiadmtegellelggnlrkgvpFATPVFDGAREEDICQQLEKAGLDRSGQVTLIDGRTGEAFDRKVTV 1280
Cdd:PRK00405   948 ----------------------------------FATPVFDGAKEEEIKELLEEAGLPEDGKTTLYDGRTGEPFDRPVTV 993
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1281 GYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVSGRTKVYEA 1360
Cdd:PRK00405   994 GYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKVYEA 1073
                         1370      1380      1390
                   ....*....|....*....|....*....|..
gi 1719379330 1361 IVRGDDNFEAGIPESFNVLVKELRSLGLNVEL 1392
Cdd:PRK00405  1074 IVKGENIPEPGIPESFNVLVKELQSLGLDVEL 1105
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
8-1392 0e+00

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 1888.60  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330    8 RKRVRKSFGRIPEVTQMPNLIEVQRSSYDHFLQMDVPPEKRANLGLQEVFRSVFPIKDFSDRAVLDFVKYELEQPKYDVE 87
Cdd:TIGR02013    1 KKRIRIDFGKIPEVLEVPNLLEIQLDSYDWFLQQDTPPEKRKEEGLEEVFKSIFPIEDYTGNIELEYLSYRLGEPKYSVE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   88 ECQQRGMTFAAPLKVTLRLSVFDvEEDTGlrsirDIKEQDVYMGDMPLMTANGTFIINGTERVIVSQMHRSPGVFFDHDK 167
Cdd:TIGR02013   81 ECKERGLTYSAPLKVKLRLINKE-EDGTK-----EIKEQDVYMGDIPLMTDRGTFIINGAERVVVSQLHRSPGVFFSSEK 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  168 GkTHSSGKYLFAARVIPYRGSWLDFEFDAKDLVYVRIDRRRKLPATTLLFALDgaetealraerkaqkkdllpyeaqgma 247
Cdd:TIGR02013  155 D-TTKSGKVLFSARIIPYRGSWLEFETDKKDVLYVRIDRKRKLPATVLLRALG--------------------------- 206
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  248 keeilnFFYDTitytrasggwktpfnadrmkgvkvasdlvdaasgqvvaeagtkmtprlikklvegglaeqlvsteeltg 327
Cdd:TIGR02013  207 ------YTIDT--------------------------------------------------------------------- 211
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  328 rylavdiinertgevlfeagdelsasdldklekagvdelpvLAIDHLNVGAYIRNTMAADRNASREDALIDIYRVMRPGE 407
Cdd:TIGR02013  212 -----------------------------------------LILNRLGSGEYIRNTLRKDPTNSEEEALVEIYRKLRPGE 250
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  408 PPTLESAEALFAGLFFDSERYDLSAVGRVKMNARLNFQTEDSVRVLRKQDIMSILKVLVNLKDGRGEIDDIDHLGNRRVR 487
Cdd:TIGR02013  251 PPTVEAARSLLENLFFDPKRYDLGRVGRYKLNKKLGLDVPESIGVLTKEDIIATIKYLIKLRNGKGEIDDIDHLGNRRIR 330
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  488 SVGELMENQYRVGLLRMERAIRERMSSVEIDTVMPHDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEITHKRRLSALG 567
Cdd:TIGR02013  331 SVGELLQNQFRVGLARMERIVRERMSTQDTDTLTPQDLINAKPISAAIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALG 410
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  568 PGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNQYGFIESPYRKVRDSIV--TDEVVYLSAMEEG 645
Cdd:TIGR02013  411 PGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLSTYARVNEYGFIETPYRKVKDGKVvvTDEIDYLTADEED 490
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  646 RYVVAQANAELDADNRFAADLVSCRQGGEYLMFRPEAIDLIDVSPKQLVSVAAALIPFLENDDANRALMGSNMQRQAVPL 725
Cdd:TIGR02013  491 NYVIAQANAPLDENGRFVEDLVVARYRGEITLVSPDQVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPL 570
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  726 VKADAPLVGTGMEATVARDSGVTIVAKRKGIVDQIDATRIVVRATDSSDATAPGVDIYNLLKFQRSNQNTCITQRPLVKV 805
Cdd:TIGR02013  571 LRSEAPLVGTGMEAKVARDSGAVIVAKRGGVVEYVDAKRIVIRYDEDEEEPDGGIDIYRLLKYQRSNQDTCINQRPIVSV 650
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  806 GDRVAAGDIIADGPSTELGELALGRNVLVAFMPWNGYNFEDSILINERIVKDDVFTSIHIEEFEVMARDTKLGQEEITRD 885
Cdd:TIGR02013  651 GDRVEAGDVLADGPSTDLGELALGRNVLVAFMPWNGYNYEDAILISERLVKDDVFTSIHIEEYEVEARDTKLGPEEITRD 730
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  886 IPNVGEEALKNLDEAGIVYIGAEVRPGDILVGKVTPKGESPMTPEEKLLRAIFGEKASDVRDTSLRLPPGVAGTIVEVRV 965
Cdd:TIGR02013  731 IPNVSEEALRNLDENGIVRIGAEVKAGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVRDTSLRVPPGVEGTVIDVKV 810
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  966 FSRrgvdkderalaieraeieklakdrdderailersfytrlkevilgqtaqsgpkgmkagtvltdaelanltkgqwrqi 1045
Cdd:TIGR02013  811 FSR----------------------------------------------------------------------------- 813
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1046 siadeqvmetveslgkvfddsiqalqnrfenkveklQRGDELPPGVMKMVKVFVAVKRKLQPGDKMAGRHGNKGVVSRIL 1125
Cdd:TIGR02013  814 ------------------------------------EQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSKIL 857
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1126 PQEDMPYLEDGQPVDLVLNPLGVPSRMNIGQILETHLGWASAGLGKqigraidqyrlamkgrgdaaqtmdglritlkeay 1205
Cdd:TIGR02013  858 PIEDMPFLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAGKRLGR---------------------------------- 903
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1206 gqkvyddqiadmtegellelggnlrKGVPFATPVFDGAREEDICQQLEKAGLDRSGQVTLIDGRTGEAFDRKVTVGYIYM 1285
Cdd:TIGR02013  904 -------------------------KGVPIATPVFDGASEEEIKEYLEKAGLPRDGKVRLYDGRTGEQFDRPVTVGYMYM 958
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1286 LKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVSGRTKVYEAIVRGD 1365
Cdd:TIGR02013  959 LKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKAYEAIVKGE 1038
                         1370      1380
                   ....*....|....*....|....*..
gi 1719379330 1366 DNFEAGIPESFNVLVKELRSLGLNVEL 1392
Cdd:TIGR02013 1039 NVPEPGIPESFNVLIKELQSLGLDIEL 1065
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
12-1392 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 1705.31  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   12 RKSFGRIPEVTQMPNLIEVQRSSYDHFLqmdvppekraNLGLQEVFRSVFPIKDFSDRAVLDFVKYELEQPKYDVEECQQ 91
Cdd:COG0085      1 RWSFAKIKEPLELPNLLEIQLDSFNWFL----------EEGLQEIFDEISPIEDFTGNLSLEFGDYRLGEPKYTPEECKE 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   92 RGMTFAAPLKVTLRLsvfdVEEDTGlrsirDIKEQDVYMGDMPLMTANGTFIINGTERVIVSQMHRSPGVFFDHDKGKth 171
Cdd:COG0085     71 RDLTYAAPLYVKVRL----VNKETG-----EIKEQEVFMGDFPLMTDSGTFIINGTERVIVSQLVRSPGVYFVEEEDK-- 139
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  172 sSGKYLFAARVIPYRGSWLDFEFDAKDLVYVRIDRRRKLPATTLLFALdGAETEalraerkaqkkdllpyeaqgmakEEI 251
Cdd:COG0085    140 -SGKDLYSAKVIPSRGAWLEFETDKDGTIYVRIDRKRKIPVTVLLRAL-GLETD-----------------------EEI 194
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  252 LNFFYDtitytrasggwktpfnadrmkgvkvasdlvdaasgqvvaeagtkmtprlikklvegglaeqlvsteeltgryla 331
Cdd:COG0085    195 LEAFGD-------------------------------------------------------------------------- 200
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  332 vDIINErtgevlfeagdelsasdldklekagvdelpvlaidhlnvgaYIRNTMAADRNASREDALIDIYRVMRPGEPPTL 411
Cdd:COG0085    201 -DPIQE-----------------------------------------YILATLEKDNTKTQEEALLEIYRKLRPGEPPTI 238
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  412 ESAEALFAGLFFDSERYDLSAVGRVKMNARLNFQTEDSVRVLRKQDIMSILKVLVNLKDGRGEIDDIDHLGNRRVRSVGE 491
Cdd:COG0085    239 ERAEQLLDNLFFDPKRYDLAHVGRYKINKKLGLDVPPEDRVLTAEDIVATIKYLLELHLGEREPDDIDHLGNRRVRLVGE 318
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  492 LMENQYRVGLLRMERAIRERMSSVEIDTVMPHDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEITHKRRLSALGPGGL 571
Cdd:COG0085    319 LLQNQFRVGLSRMERVVRERMTTQDVEAITPQSLINIRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGL 398
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  572 TRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNQYGFIESPYRKVRDSIVTDEVVYLSAMEEGRYVVAQ 651
Cdd:COG0085    399 SRERAGFEVRDVHPSHYGRMCPIETPEGPNIGLIGSLALYARVNEYGFIETPYRKVENGKVTDEIEYLTADEEENYYIAQ 478
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  652 ANAELDADNRFAADLVSCRQGGEYLMFRPEAIDLIDVSPKQLVSVAAALIPFLENDDANRALMGSNMQRQAVPLVKADAP 731
Cdd:COG0085    479 ANAPLDEDGNFLEERVLVRYRGEEVLVPPEEVDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPEAP 558
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  732 LvgtgmeatvardsgvtivakrkgivdqidatrivvratdssdatapgvDIYNLLKFQRSNQNTCITQRPLVKVGDRVAA 811
Cdd:COG0085    559 L------------------------------------------------LHYPLQKFQRSNQGTCINQRPIVRVGDRVEK 590
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  812 GDIIADGPSTELGELALGRNVLVAFMPWNGYNFEDSILINERIVKDDVFTSIHIEEFEVMARDTKLGQEEITRDIPNVGE 891
Cdd:COG0085    591 GDVLADGPATDNGELALGQNLLVAFMPWEGYNYEDAIIISERLVKDDVLTSIHIEEYEIEARDTKLGPEEITRDIPNVSE 670
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  892 EALKNLDEAGIVYIGAEVRPGDILVGKVTPKGESPMTPEEKLLRAIFGEKASDVRDTSLRLPPGVAGTIVEVRVFSRrgv 971
Cdd:COG0085    671 EALRNLDEDGIIRIGAEVKGGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLRVPHGEKGKVIDVKVFSR--- 747
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  972 dkderalaieraeieklakdrdderailersfytrlkevilgqtaqsgpkgmkagtvltdaelanltkgqwrqisiadeq 1051
Cdd:COG0085        --------------------------------------------------------------------------------
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1052 vmetveslgkvfddsiqalqnrfENkveklqrGDELPPGVMKMVKVFVAVKRKLQPGDKMAGRHGNKGVVSRILPQEDMP 1131
Cdd:COG0085    748 -----------------------EE-------GDELPPGVNKLVRVYVAQKRKIEVGDKLAGRHGNKGVISRILPQEDMP 797
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1132 YLEDGQPVDLVLNPLGVPSRMNIGQILETHLGWASAGLGKQIgraidqyrlamkgrgdaaqtmdglritlkeaygqkvyd 1211
Cdd:COG0085    798 FLEDGTPVDIVLNPLGVPSRMNVGQVLETHLGWAAALLGRRV-------------------------------------- 839
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1212 dqiadmtegellelggnlrkgvpfATPVFDGAREEDICQQLEKAGLDRSGQVTLIDGRTGEAFDRKVTVGYIYMLKLHHL 1291
Cdd:COG0085    840 ------------------------ATPVFDGAPEEEIRELLEKAGLPPDGKEVLYDGRTGEPFDNPVTVGYMYYLKLHHM 895
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1292 VDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVSGRTKVYEAIVRGDDNFEAG 1371
Cdd:COG0085    896 VDDKIHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQERLTIKSDDVCGRVKVYEAIVKGENIPEPG 975
                         1370      1380
                   ....*....|....*....|.
gi 1719379330 1372 IPESFNVLVKELRSLGLNVEL 1392
Cdd:COG0085    976 IPESFKVLLKELQSLGLDVEV 996
PRK14844 PRK14844
DNA-directed RNA polymerase subunit beta/beta';
26-1394 0e+00

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 173305 [Multi-domain]  Cd Length: 2836  Bit Score: 1595.81  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   26 NLIEVQRSSYDHFlqmdvPPEKRANLGLQEVFRSVFPIKDFSDRAVLDFVKYELEQPKYDVEECQQRGMTFAAPLKVTLR 105
Cdd:PRK14844    31 DLVKVQKESYDSF-----TPKNKGNERLEVIFHTIFPINDPLHRATIEFISCRVDDPKYDESECIKRGITFSAQVIASIR 105
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  106 LSVF----DVEEDTGLRS----------IRDIKEQDVYMGDMPLMTANGTFIINGTERVIVSQMHRSPGVFFDHDKGKTH 171
Cdd:PRK14844   106 LVIMqdgiSLDEYKSIKEsgdhsklatvIKSIEEQEVHFCELPMMTDKGTFIINGVEKVIVSQMHRSPGVFFDSDKGKTY 185
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  172 SSGKYLFAARVIPYRGSWLDFEFDAKDLVYVRIDRRRKLPATTLLFALdgaetealraerkaqkkdllpyeaqGMAKEEI 251
Cdd:PRK14844   186 NSGKLIYSARVIPYRGSWLDIEFDVKDHLYFRIDRKRKLPISVLLKAL-------------------------GLSNNDI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  252 LNFFYDTITYTRASGGWKTPFNADRMKGVKVASDLVDAaSGQVVAEAGTKMTPRLIKKLVEGGLAEQLVSTEELTGRYLA 331
Cdd:PRK14844   241 LDRFYEKIKYIKHKDGWKVPFVPDKFKGVRLPFDLMDV-EGNVLLKANVRITSRLAKKLYDNELKEYLVPFDSICGLFLA 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  332 VDIINERTGEVLFEAGDELSASDLDKLEKAGVDELPVLAIDHLNVGAYIRNTMAADRNASREDALIDIYRVMRPGEPPTL 411
Cdd:PRK14844   320 EDLIDSASSTKILSAGESIKLEDIKKLELLSIDEISVLNIDNLSVGPYILNTLFLDENMSYQDALYEIYKVLRPGEVPVL 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  412 ESAEALFAGLFFDSERYDLSAVGRVKMNARLNFQTEDSVRVLRKQDIMSILKVLVNLKDGRGEIDDIDHLGNRRVRSVGE 491
Cdd:PRK14844   400 EIVEEFFRNLFFSPEYYDLSNIGRLKLNSYLGLNYDEDLTVLTHEDIIEIVRKIVLLRDGQGSVDDIDHLGNRRVRSVGE 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  492 LMENQYRVGLLRMERAIRERMSSVEIDTVMPHDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEITHKRRLSALGPGGL 571
Cdd:PRK14844   480 FIENQFRTGLLKLERAVVDSMSTSSLDKVSPSDFINPKVLTNVLRDFFNSSQLSQFMDQTNPLSEITHKRRLSALGPGGL 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  572 TRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNQYGFIESPYRKVRDSIVTDEVVYLSAMEEGRYVVAQ 651
Cdd:PRK14844   560 TRERAGFEVRDVHPTHYGRICPIETPEGQNIGLINSLAIYARINKYGFIESPYRKVVNRVVTDQIEYLSAIDEGLYYIAD 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  652 ANAELDADNRFAADLVSCRQGGEYLMFRPEAIDLIDVSPKQLVSVAAALIPFLENDDANRALMGSNMQRQAVPLVKADAP 731
Cdd:PRK14844   640 TSAKLDENNCFVDDMLYCRYAGSFVMVSSDQVSYIDVSPKQVISVAASLIPFLENDDANRALMGSNMQRQAVPLLKPTAP 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  732 LVGTGMEATVARDSGVTIVAKRKGIVDQIDATRIVVRATDSSDATAPGVDIYNLLKFQRSNQNTCITQRPLVKVGDRVAA 811
Cdd:PRK14844   720 LVATGMESFVASGSGAVVLAKRDGIVDSSDSNSIVIRAFDKERVNYLDVDIYHLRKFQRSNHNTCINQKPLVCVGDYVKE 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  812 GDIIADGPSTELGELALGRNVLVAFMPWNGYNFEDSILINERIVKDDVFTSIHIEEFEVMARDTKLGQEEITRDIPNVGE 891
Cdd:PRK14844   800 GDVIADGPAINSGELALGQNLLVAFMSWQGYNFEDSIIISSEVVKKDLFTSIHIEEFECVVHDTPLGSEKITRAIPGVNE 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  892 EALKNLDEAGIVYIGAEVRPGDILVGKVTPKGESPMTPEEKLLRAIFGEKASDVRDTSLRLPPGVAGTIVEVRVFSRRGV 971
Cdd:PRK14844   880 ENLYHLDDSGIVKIGTRVGPGYILVGKVTPKPSLSLPPETKLLMTIFGEKSFDCADSSLYTSPDVEGTVIDVQVFTRRGV 959
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  972 DKDERALAIERAEIEKLAKDRDDERAILERSFYTRLKEVILGQTAQSGPKgmkagtvltdaeLANLTKGQWRQISIADEQ 1051
Cdd:PRK14844   960 EENERALLIKQKEINDFEKERDYIINVTSEYFYDELKKLLINSGSQDREK------------FDSIEREQWWGIGLKNQS 1027
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1052 VMETVESLGKVFDDSIQALQNRFENKVEKLQRGDELPPGVMKMVKVFVAVKRKLQPGDKMAGRHGNKGVVSRILPQEDMP 1131
Cdd:PRK14844  1028 ISEQVKSLKKDFDEKVSHAIAQFKRKVEKLHEGYDLPQGVSMSVKVFIAVKHSLQPGDKMAGRHGNKGVISRVVPVEDMP 1107
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1132 YLEDGQPVDLVLNPLGVPSRMNIGQILETHLGWASAGLGKQIGRAIDQ-------YRLAMKGRGD------AAQTMDGLR 1198
Cdd:PRK14844  1108 YLEDGTPVDIILNPLGVPSRMNVGQILETHVGWACKKLGEKVGNILDEinkiksaFCKGIRSLNDdnftkfAAAYLDNKK 1187
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1199 I----------------------------------TLKEAYGQ------KVYD--------DQIADMTEGELLELGGNLR 1230
Cdd:PRK14844  1188 IenidddeitasvlntpnknalndelnelvenylnSCKSAYSNlrnfliEVYScgsnvsicNNIRDISDNNLIEFARKLR 1267
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1231 KGVPFATPVFDGAREEDICQQLEKAGLDRSGQVTLIDGRTGEAFDRKVTVGYIYMLKLHHLVDDKIHARSIGPYSLVTQQ 1310
Cdd:PRK14844  1268 DGIPVAAPVFEGPKDEQIAKLFELAGLDNSGQAVLYDGCSGEKFDRKVTVGYMYMLKLHHLVDGKIHARSVGPYSLVTQQ 1347
                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1311 PLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVSGRTKVYEAIVRGDDNFEAGIPESFNVLVKELRSLGLNV 1390
Cdd:PRK14844  1348 PLGGKSHFGGQRFGEMECWALQAYGAAYTLQEMLTVKSDDINGRVKIYESIIKGDSNFECGIPESFNVMIKELRSLCLNV 1427

                   ....
gi 1719379330 1391 ELNQ 1394
Cdd:PRK14844  1428 DLKQ 1431
PRK09603 PRK09603
DNA-directed RNA polymerase subunit beta/beta';
1-1392 0e+00

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 181983 [Multi-domain]  Cd Length: 2890  Bit Score: 1455.90  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330    1 MAKSFTGRKRVRKSFGRIPEVTQMPNLIEVQRSSYDHFLQMDVPPEKranlGLQEVFRSVFPIKDFSDRAVLDFVKYELE 80
Cdd:PRK09603     1 MSKKIPLKNRLRADFTKTPTDLEVPNLLLLQRDSYDSFLYSKDGKES----GIEKVFKSIFPIQDEHNRITLEYAGCEFG 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   81 QPKYDVEECQQRGMTFAAPLKVTLRLSVFDVEEDTGLR-SIRDIKEQDVYMGDMPLMTANGTFIINGTERVIVSQMHRSP 159
Cdd:PRK09603    77 KSKYTVREAMERGITYSIPLKIKVRLILWEKDTKSGEKnGIKDIKEQSIFIREIPLMTERTSFIINGVERVVVNQLHRSP 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  160 GVFFDHDKGKThSSGKYLFAARVIPYRGSWLDFEFDAKDLVYVRIDRRRKLPATTLLFALdgaetealraerkaqkkdll 239
Cdd:PRK09603   157 GVIFKEEESST-SLNKLIYTGQIIPDRGSWLYFEYDSKDVLYARINKRRKVPVTILFRAM-------------------- 215
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  240 pyeaqGMAKEEILNFFYDTITYTRASGGWKTPFNADRMKGvKVASDLVDAaSGQVVAEAGTKMTPRLIKKLVEGGLAEQL 319
Cdd:PRK09603   216 -----DYQKQDIIKMFYPLVKVRYENDKYLIPFASLDANQ-RMEFDLKDP-QGKIILLAGKKLTSRKIKELKENHLEWVE 288
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  320 VSTEELTGRYLAVDIINERtgEVLFEAGDELSASDLDKLEKAGVDELPVLAIDHLNVGAYIRNTMAADRNASR------- 392
Cdd:PRK09603   289 YPMDILLNRHLAEPVMVGK--EVLLDMLTQLDKNKLEKIHDLGVQEFVIINDLALGHDASIIHSFSADSESLKllkqtek 366
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  393 -----EDALIDIYRVMRPGEPPTLESAEALFAGLFFDSERYDLSAVGRVKMNARLNFQTEDSVRVLRKQDIMSILKVLVN 467
Cdd:PRK09603   367 iddenALAAIRIHKVMKPGDPVTTEVAKQFVKKLFFDPERYDLTMVGRMKMNHKLGLHVPDYITTLTHEDIITTVKYLMK 446
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  468 LKDGRGEIDDIDHLGNRRVRSVGELMENQYRVGLLRMERAIRERMSSVEI--DTVMPHDLINAKPAAAAVREFFGSSQLS 545
Cdd:PRK09603   447 IKNNQGKIDDRDHLGNRRIRAVGELLANELHSGLVKMQKTIKDKLTTMSGafDSLMPHDLVNSKMITSTIMEFFMGGQLS 526
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  546 QFMDQTNPLSEITHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNQYGFIESPYR 625
Cdd:PRK09603   527 QFMDQTNPLSEVTHKRRLSALGEGGLVKDRVGFEARDVHPTHYGRICPIETPEGQNIGLINTLSTFTRVNDLGFIEAPYK 606
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  626 KVRDSIVTDEVVYLSAMEEGRYVVAQANAELDADNRFAADLVSCRQGGEYLMFRPEAIDLIDVSPKQLVSVAAALIPFLE 705
Cdd:PRK09603   607 KVVDGKVVGETIYLTAIQEDSHIIAPASTPIDEEGNILGDLIETRVEGEIVLNEKSKVTLMDLSSSMLVGVAASLIPFLE 686
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  706 NDDANRALMGSNMQRQAVPLVKADAPLVGTGMEATVARDSGVTIVAKRKGIVDQIDATRIVVRATDSSDATapgVDIYNL 785
Cdd:PRK09603   687 HDDANRALMGTNMQRQAVPLLRSDAPIVGTGIEKIIARDSWGAIKANRAGVVEKIDSKNIYILGEGKEEAY---IDAYSL 763
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  786 LKFQRSNQNTCITQRPLVKVGDRVAAGDIIADGPSTELGELALGRNVLVAFMPWNGYNFEDSILINERIVKDDVFTSIHI 865
Cdd:PRK09603   764 QKNLRTNQNTSFNQVPIVKVGDKVEAGQIIADGPSMDRGELALGKNVRVAFMPWNGYNFEDAIVVSERITKDDIFTSTHI 843
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  866 EEFEVMARDTKLGQEEITRDIPNVGEEALKNLDEAGIVYIGAEVRPGDILVGKVTPKGESPMTPEEKLLRAIFGEKASDV 945
Cdd:PRK09603   844 YEKEVDARELKHGVEEFTADIPDVKEEALAHLDESGIVKVGTYVSAGMILVGKTSPKGEIKSTPEERLLRAIFGDKAGHV 923
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  946 RDTSLRLPPGVAGTIVEVRVFSRRGVDKDERALAIERAEIEKLAKDRDDERAILERSFYTR----LKEVILGQTAQSGPK 1021
Cdd:PRK09603   924 VNKSLYCPPSLEGTVIDVKVFTKKGYEKDARVLSAYEEEKAKLDMEHFDRLTMLNREELLRvsslLSQAILEEPFSHNGK 1003
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1022 GMKAGTVLTDAELANLTKGQWRQ-ISIADEQVMETVESLGKVFDDSIQALQNRFENKVEKLQRGDELPPGVMKMVKVFVA 1100
Cdd:PRK09603  1004 DYKEGDQIPKEEIASINRFTLASlVKKYSKEVQNHYEITKNNFLEQKKVLGEEHEEKLSILEKDDILPNGVIKKVKLYIA 1083
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1101 VKRKLQPGDKMAGRHGNKGVVSRILPQEDMPYLEDGQPVDLVLNPLGVPSRMNIGQILETHLGWASAGLGKQIGRAIDQy 1180
Cdd:PRK09603  1084 TKRKLKVGDKMAGRHGNKGIVSNIVPVADMPYTADGEPVDIVLNPLGVPSRMNIGQILEMHLGLVGKEFGKQIASMLED- 1162
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1181 rlamkgrgDAAQTMDGLRITLKEAY-----GQKVYDDQIADMTEGELLELGGNLRKGVPFATPVFDGAREEDICQQLEKA 1255
Cdd:PRK09603  1163 --------KTKDFAKELRAKMLEIAnaineKDPLTIHALENCSDEELLEYAKDWSKGVKMAIPVFEGISQEKFYKLFELA 1234
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1256 GLDRSGQVTLIDGRTGEAFDRKVTVGYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYG 1335
Cdd:PRK09603  1235 KIAMDGKMDLYDGRTGEKMRERVNVGYMYMIKLHHLVDEKVHARSTGPYSLVTHQPVGGKALFGGQRFGEMEVWALEAYG 1314
                         1370      1380      1390      1400      1410
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1719379330 1336 AAYTLQEMLTVKSDDVSGRTKVYEAIVRGDDNFEAGIPESFNVLVKELRSLGLNVEL 1392
Cdd:PRK09603  1315 AAHTLKEMLTIKSDDIRGRENAYRAIAKGEQVGESEIPETFYVLTKELQSLALDINI 1371
rpoB CHL00207
RNA polymerase beta subunit; Provisional
22-1397 0e+00

RNA polymerase beta subunit; Provisional


Pssm-ID: 214397 [Multi-domain]  Cd Length: 1077  Bit Score: 1109.00  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   22 TQMPNLIEVQRSSYDHFLqmdvppekraNLGLQEVFRSVFPIKDFSDRA--VLDFVKYELEQPKYDVEECQQRGMTFAAP 99
Cdd:CHL00207     5 FALPDFLEIQRTSFCWFL----------NEGLNEELNIFSKIFDYTGNLelLLFGKNYKLKYPKYNLLSAKSYDSNYSIQ 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  100 LKVTLRLSVFDveedtglrsIRDIKEQDVYMGDMPLMTANGTFIINGTERVIVSQMHRSPGVFFDHDKGKTHssgKYLFA 179
Cdd:CHL00207    75 IYLPLKFINLK---------TNKIKFINYLIGNLPKMTQRGTFIINGLERVIVSQIIRSPGIYFKKEIKKNS---NKIYS 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  180 ARVIPYRGSWLDFEFDAKDLVYVRIDRRRKLPATTLLFALdgaetealraerkaqkkdllpyeaqGMAKEEILNFfydtI 259
Cdd:CHL00207   143 ATLIPNRGSWIKFELDKNKEIWIRIDKNRKKPLIIFLKAL-------------------------GLTDQDIYSR----L 193
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  260 TYTRasggwktpfnadrmkgvkvasdlvdaasgqvvaeagtkmTPRLIKKLvegglaeqLVSTEELTgrylavdiinert 339
Cdd:CHL00207   194 TKSE---------------------------------------FLKKLKPI--------LLNSNSYT------------- 213
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  340 gevlfeagdelsasdldklekagvdelpvlaidhlnvgayirntmaadrnasREDALIDIYRVMRPGEPPTLESAEALFA 419
Cdd:CHL00207   214 ----------------------------------------------------NEEILLEIYKNLSPIEPATVNDANQNLF 241
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  420 GLFFDSERYDLSAVGRVKMNARLNFQTEDSVRVLRKQDIMSILKVLVNLKDGRGEIDDIDHLGNRRVRSVGELMENQYRV 499
Cdd:CHL00207   242 SRFFDPKNYDLGKVGRYKINNKLNLNIPERVRNLTYEDILSIIDKLINLKINKGNFDDIDHLKNRRVRSVGELLQNQFRI 321
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  500 GLLRMERAIRERMSSVEIDTVMPHDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEITHKRRLSALGPGGLTRERAGFE 579
Cdd:CHL00207   322 GLKRLERILRNRMTICDIDSLSKFNLINPKPLIALIREFFGSSQLSQYMDQTNPLSELTHKRRISILGPGGLDKDRISFA 401
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  580 VRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNQYGFIESPYRKVRDS--IVTDEVVYLSAMEEGRYVVAQANAELD 657
Cdd:CHL00207   402 VRDIHPSHYGRICPIETPEGPNCGLIGSLATNARINKFGFIETPFYKVINGkvKKFGNPIYLTADSEDLYRIAPNDINLN 481
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  658 ADNRFAADLVSCRQGGEYLMFRPEAIDLIDVSPKQLVSVAAALIPFLENDDANRALMGSNMQRQAVPLVKADAPLVGTGM 737
Cdd:CHL00207   482 KNNYFKKNIIPVRYKQEFKTVNPSKVDFIAISPIQVFSIAESLIPFLEHNDANRALMGSNMQRQAVPLLYPEKPIVGTGY 561
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  738 EATVARDSGVTIVAKRKGIVDQIDATRIVVRatdssDATAPGVdIYNLLKFQRSNQNTCITQRPLVKVGDRVAAGDIIAD 817
Cdd:CHL00207   562 EKQIALDSGMTIISLTEGIVVSVSAYKIIIQ-----DDNNRYI-HYYLQKYQRSNQNTCINYRPIVWVGEKINIGQILAD 635
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  818 GPSTELGELALGRNVLVAFMPWNGYNFEDSILINERIVKDDVFTSIHIEEFEVMARDTKLGQEEITRDIPNVGEEALKNL 897
Cdd:CHL00207   636 GSDIDNSELALGQNVLVAYMPWEGYNFEDAILINKRLVYEDLFTSIHIEKYEIELRQTKLGSEEITRNIPNVSEYSLKNL 715
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  898 DEAGIVYIGAEVRPGDILVGKVTPKGESPMTPEEKLLRAIFGEKASDVRDTSLRLPPGVAGTIVEVRVFSRRgvdkdera 977
Cdd:CHL00207   716 DENGIISIGSKVLAGDILVGKITPKGESDQLPEGKLLRAIFGEKAKDVKDTSLRMPNGGYGRVIKVEIFSRS-------- 787
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  978 laieraeieklakdrdderailersfytrlkevilgqtaqsgpkgmkagtvltdaelanltkgqwrqisiadeqvmetve 1057
Cdd:CHL00207       --------------------------------------------------------------------------------
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1058 slgkvfddsiqalqnrfenkveklqRGDELPPGVMKMVKVFVAVKRKLQPGDKMAGRHGNKGVVSRILPQEDMPYLEDGQ 1137
Cdd:CHL00207   788 -------------------------KGDELKFGYYLKIRVFIAQIRKIQVGDKLAGRHGNKGIISRILPRQDMPYLPDGT 842
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1138 PVDLVLNPLGVPSRMNIGQILETHLGWASAGLGKQIGRA-IDqyrlamkgrgdaaqTMDGL---RITLKEAYGQkvyddq 1213
Cdd:CHL00207   843 PPDIILNPLGVPSRMNVGQLFECLLGLAGDNLNKRFKILpFD--------------EMYGSeysRILINNKLNQ------ 902
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1214 iADMTEGELLELGGNLrkgvpfatpvfdgareedicqqlekagldrSGQVTLIDGRTGEAFDRKVTVGYIYMLKLHHLVD 1293
Cdd:CHL00207   903 -ASIKNNEYWLFNSYH------------------------------PGKMVLRDGRTGYKFKNPVTVGIAYMLKLIHLVD 951
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1294 DKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVSGRTKVYEAIVRGDDNFEAGIP 1373
Cdd:CHL00207   952 DKIHARTTGPYSLVTQQPLGGKAQHGGQRFGEMEVWALEAFGAAYTLKELLTIKSDDMQGRNETLNAIVKGQPIPKPGTP 1031
                         1370      1380
                   ....*....|....*....|....
gi 1719379330 1374 ESFNVLVKELRSLGLNVELNQRSY 1397
Cdd:CHL00207  1032 ESFKVLMRELQSLGLDIEAYKIEN 1055
rpoB CHL00001
RNA polymerase beta subunit
25-1396 0e+00

RNA polymerase beta subunit


Pssm-ID: 214330 [Multi-domain]  Cd Length: 1070  Bit Score: 1108.43  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   25 PNLIEVQRSSYDHFLqmdvppekraNLGLQEVFRSVFPIKDfSDRAV--LDFVK-YELEQPKYDVEECQQRGMTFAAPLK 101
Cdd:CHL00001    13 PGFNQIQFEGFCRFI----------DQGLTEELSKFPKIED-TDQEIefQLFVEtYQLVEPLIKERDAVYESLTYSSELY 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  102 VTLRLSvfdveedtgLRSIRDIKEQDVYMGDMPLMTANGTFIINGTERVIVSQMHRSPGVFF----DHDKGKTHSsgkyl 177
Cdd:CHL00001    82 VPAGLI---------WKKSRDMQEQTVFIGNIPLMNSLGTFIINGIYRVVINQILRSPGIYYrselDHNGISVYT----- 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  178 faARVIPYRGSWLDFEFDAKDLVYVRIDRRRKLPATTLLFALdgaetealraerkaqkkdllpyeaqGMAKEEILnffyD 257
Cdd:CHL00001   148 --GTIISDWGGRLELEIDRKARIWARVSRKQKISILVLLSAM-------------------------GLNLREIL----D 196
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  258 TITYtrasggwktpfnadrmkgvkvasdlvdaasgqvvaeagtkmtprlikklvegglAEQLVSTEeltgrylavdiine 337
Cdd:CHL00001   197 NVCY------------------------------------------------------PEIFLSFL-------------- 208
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  338 rtgevlfeagdelsasdLDKLEKagvdelpvlaidhlNVGayirntmaadrnaSREDALIDIYR--VMRPGEPPTLESAE 415
Cdd:CHL00001   209 -----------------NDKEKK--------------KIG-------------SKENAILEFYQqfACVGGDPVFSESLC 244
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  416 ALFAGLFFDSeRYDLSAVGRVKMNARLNFQTEDSVRVLRKQDIMSILKVLVNLKDGRGEIDDIDHLGNRRVRSVGELMEN 495
Cdd:CHL00001   245 KELQKKFFQQ-RCELGRIGRRNMNRKLNLDIPENNTFLLPQDVLAAADYLIGMKFGMGTLDDIDHLKNKRIRSVADLLQD 323
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  496 QYRVGLLRMERAIRERMSSVEIDTVM--PHDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEITHKRRLSALGPGGLTR 573
Cdd:CHL00001   324 QFGLALNRLENAVRGTICGAIRRKLIptPQNLVTSTPLTTTYESFFGSHPLSQFLDQTNPLTEIVHGRKLSSLGPGGLTG 403
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  574 ERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNQYGFIESPYRKVRDSIVTDEVVYLSAMEEGRYVVAQAN 653
Cdd:CHL00001   404 RTASFRVRDIHPSHYGRICPIDTSEGINAGLIGSLAIHARIGHWGSLESPFYEISERSKEERMVYLSPSEDEYYMIAAGN 483
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  654 AeLDADNRFAAD-LVSCRQGGEYLMFRPEAIDLIDVSPKQLVSVAAALIPFLENDDANRALMGSNMQRQAVPLVKADAPL 732
Cdd:CHL00001   484 S-LALNQGIQEEqVVPARYRQEFLTIAWEQIHLRSIFPFQYFSIGASLIPFLEHNDANRALMGSNMQRQAVPLSRSEKCI 562
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  733 VGTGMEATVARDSGVTIVAKRKGIVDQIDATRIVVRATDSsdatapgVDIYNLLKFQRSNQNTCITQRPLVKVGDRVAAG 812
Cdd:CHL00001   563 VGTGLERQVALDSGVVAIAEHEGKIIYTDTDKIILSGNGD-------TLSIPLVMYQRSNKNTCMHQKPQVRRGKCVKKG 635
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  813 DIIADGPSTELGELALGRNVLVAFMPWNGYNFEDSILINERIVKDDVFTSIHIEEFEVMARDTKLGQEEITRDIPNVGEE 892
Cdd:CHL00001   636 QILADGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYTSFHIRKYEIQTHVTSQGPERITKEIPHLEAH 715
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  893 ALKNLDEAGIVYIGAEVRPGDILVGKVTPK--GESPMTPEEKLLRAIFGEKASDVRDTSLRLPPGVAGTIVEVRvfsrrg 970
Cdd:CHL00001   716 LLRNLDKNGIVMLGSWVETGDILVGKLTPQeaEESSYAPEGRLLRAIFGIQVSTSKETCLKLPIGGRGRVIDVR------ 789
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  971 vdkderalaieraeieklakdrdderailersfytrlkevilgqtaqsgpkgmkagtvltdaelanltkgqWRQisiade 1050
Cdd:CHL00001   790 -----------------------------------------------------------------------WIQ------ 792
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1051 qvmetveslgkvfddsiqalqnrfenkveklqrGDELPPGVMKMVKVFVAVKRKLQPGDKMAGRHGNKGVVSRILPQEDM 1130
Cdd:CHL00001   793 ---------------------------------KKGGSSYNPETIHVYILQKREIQVGDKVAGRHGNKGIISKILPRQDM 839
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1131 PYLEDGQPVDLVLNPLGVPSRMNIGQILETHLGWASAGLGKqigraidQYRLAmkgrgdaaqtmdglriTLKEAYGQKVY 1210
Cdd:CHL00001   840 PYLQDGTPVDMVLNPLGVPSRMNVGQIFECLLGLAGDLLNR-------HYRIA----------------PFDERYEQEAS 896
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1211 ddqiadmtegellelggnlRKgvpfatPVFdgareedicQQLEKAG----------LDRSGQVTLIDGRTGEAFDRKVTV 1280
Cdd:CHL00001   897 -------------------RK------LVF---------SELYEASkqtanpwvfePEYPGKSRLFDGRTGDPFEQPVTI 942
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1281 GYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVSGRTKVYEA 1360
Cdd:CHL00001   943 GKAYILKLIHQVDDKIHARSSGPYALVTQQPLRGRSKQGGQRVGEMEVWALEGFGVAYILQEMLTYKSDHIRARQEVLGA 1022
                         1370      1380      1390
                   ....*....|....*....|....*....|....*...
gi 1719379330 1361 IVRGD--DNFEaGIPESFNVLVKELRSLGLNVELNQRS 1396
Cdd:CHL00001  1023 IITGGtiPKPE-DAPESFRLLVRELRSLALELNHFLVS 1059
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
27-1393 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 863.42  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   27 LIEVQRSSYDHFLQMdvppekranlGLQEVFRSVFPIKDFSD--RAVLDFVKYELEQP---------KYDVEECQQRGMT 95
Cdd:cd00653      1 LVKQQIDSFNYFLNV----------GLQEIVKSIPPITDTDDdgRLKLKFGDIYLGKPkveeggvtrKLTPNECRLRDLT 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   96 FAAPLKVTLRLSVFDveedtglrsIRDIKEQDVYMGDMPLMTANGTFIING---TERVIVSQMHRSPGVFFdhdkgkths 172
Cdd:cd00653     71 YSAPLYVDIRLTVND---------KGKIKEQEVFIGEIPIMLRSKLCNLNGltpEELIKLGECPLDPGGYF--------- 132
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  173 sgkylfaarVIpyRGSwldfEfdaKDLVYVrIDRRRklpattllfaldgaetealraerkaqkkdllpyeaqgmakeeil 252
Cdd:cd00653    133 ---------II--NGT----E---KVIINQ-EQRSP-------------------------------------------- 149
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  253 NFFYdtitytrasggwktpfnADRMKGVKVASdlvdaasgqvvaeagtkmtprlikklvegglaeqlvsteeltgrylaV 332
Cdd:cd00653    150 NVII-----------------VEDSKGKRIYT-----------------------------------------------K 165
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  333 DIINERTGEvlfeAGDELSASDLDKlekagvdelpvlaIDHLNVGAYIRNtmaadrnasREDALIDIYRVMRpgepptle 412
Cdd:cd00653    166 TSIPSYSPY----RGSWLEVKSDKK-------------KDRIYVRIDLKR---------QEEALKYIGKRFE-------- 211
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  413 saealfaglffdserydlsavgrvkmnarlnfqtedsvrvlrkqDIMSILKVLVNLKDGRGEIDDIDHLGNRRVRSVGEL 492
Cdd:cd00653    212 --------------------------------------------DLIYMIRKLILLVLGKGKLDDIDHLGNKRVRLAGEL 247
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  493 MENQYRVGLLRMERAIRERMSSVEI--DTVMPHDLINAKPAAAAVREFFGSSQ------------LSQFMDQTNPLSEIT 558
Cdd:cd00653    248 LQNLFRSGLKRLEREVKEKLQKQLSkkKDLTPQLLINSKPITSGIKEFLATGNwgskrflmqrsgLSQVLDRLNPLSELS 327
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  559 HKRRLSAlgpGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNqyGFIESPYRKVRDSIvtdevvy 638
Cdd:cd00653    328 HKRRISS---LGLFRERKGFEVRDLHPSHWGRICPIETPEGENCGLVKNLALMARIS--GRIERPYRIVEKEV------- 395
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  639 lsameegryvvaqanaeldadnrfaadlvscrqggeylmfrpeaiDLIDVSPKQLVSVAAALIPFLENDDANRALMGSNM 718
Cdd:cd00653    396 ---------------------------------------------THIEISPSQILSVAASLIPFPEHNQSPRNLYQSNM 430
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  719 QRQAVPlvkadaplvgtgmeatvardsgvtivakrkgivdqIDATRIVVRaTDSSdatapgvdIYNLLKfqrsnqntciT 798
Cdd:cd00653    431 QKQAVG-----------------------------------TPALNQQYR-MDTK--------LYLLLY----------P 456
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  799 QRPLVKVGDRvaagDIIAdgpsteLGELALGRNVLVAFMPWNGYNFEDSILINERIVKDDVFTSIHIEEFEVMARDTKLG 878
Cdd:cd00653    457 QKPLVGTGIE----EYIA------FGELPLGQNAIVAVMSYSGYNFEDAIIINKSSVDRGFFRSIHYKKYEIELRKTKNG 526
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  879 QEEITR-DIPNVGEEALKNLDEAGIVYIGAEVRPGDILVGKVTPKGESPMTPeekllraIFGEKASDVRDTSLRLPPGVA 957
Cdd:cd00653    527 PEEITRgDIPNVSEEKLKNLDEDGIIRPGARVEPGDILVGKITPKGETESTP-------IFGEKARDVRDTSLKYPGGEK 599
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  958 GTIVEVRVFSRrgvdkderalaieraeieklakdrdderailersfytrlkevilgqtaqsgpkgmkagtvltdaelanl 1037
Cdd:cd00653    600 GIVDDVKIFSR--------------------------------------------------------------------- 610
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1038 tkgqwrqisiadeqvmetveslgkvfddsiqalqnrfenkveklqrgdELPPGVMKMVKVFVAVKRKLQPGDKMAGRHGN 1117
Cdd:cd00653    611 ------------------------------------------------ELNDGGNKLVKVYIRQKRKPQIGDKFASRHGQ 642
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1118 KGVVSRILPQEDMPYLEDGQPVDLVLNPLGVPSRMNIGQILETHLGWASAGLGKQIgraidqyrlamkgrgdaaqtmdgl 1197
Cdd:cd00653    643 KGVISKILPQEDMPFTEDGIPPDIILNPHGFPSRMTIGQLLESLLGKAGALLGKFG------------------------ 698
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1198 ritlkeaygqkvyddqiadmtegellelggnlrkgvpFATPvFDGAREEDICQQLEKAGLDRSGQVTLIDGRTGEAFDRK 1277
Cdd:cd00653    699 -------------------------------------DATP-FDGAEEEDISELLGEAGLNYYGKEVLYDGRTGEPLEAP 740
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1278 VTVGYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVSGRTKV 1357
Cdd:cd00653    741 IFVGPVYYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQRFGEMERDALIAHGAAYLLQERLTIKSDDVVARVCV 820
                         1370      1380      1390      1400
                   ....*....|....*....|....*....|....*....|....*.
gi 1719379330 1358 YEAIV----------RGDDNFEAGIPESFNVLVKELRSLGLNVELN 1393
Cdd:cd00653    821 KCGIIlsanlcrlckKGTNISKVGIPYAFKLLFQELQSMNIDPRLK 866
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
750-1317 3.84e-177

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 530.56  E-value: 3.84e-177
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  750 VAKRKGIVDQIDATRIVVRATDSSDAtapgVDIYNLLKFQRSNQNT---CITQRPLVKVGdRVAAGDiiadgpsteLGEL 826
Cdd:pfam00562    1 VASLIPFVDHNQSPRNTYQCAMGKQA----MGIYTLNKFYRSDQNTyvlCYPQKPLVKTG-AVEAGG---------FGEL 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  827 ALGRNVLVAFMPWNGYNFEDSILINERIVKDDVFTSIHIEEFEvmARDTKLGQ-EEITRDIPNVGEEALKNLDEAGIVYI 905
Cdd:pfam00562   67 PLGQNAIVAVMSYTGYNQEDAIIINKSSVDRGFFTSIHIKEIE--ARKTKLGPiEEITRDIPNVSEEALKKLDEDGIVRV 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  906 GAEVRPGDILVGKVTPkgespmTPEEKLLRAIFGEKASDVRDTSLRLPPGVAGTIVEVRVFsrrgvdkderalaieraei 985
Cdd:pfam00562  145 GAEVKPGDILVGKVGP------TELTKLLRAIFGEKARDVKDTSLKVPPGEEGVVDDVIVF------------------- 199
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  986 eklakdrdderailersfytrlkevilgqtaqsgpkgmkagtvltdaelanltkgqwrqisiadeqvmetveslgkvfdd 1065
Cdd:pfam00562      --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1066 siqalqnrfenkveklqrgdELPPGVMKMVKVFVAVKRKLQPGDKMAGRHGNKGVVSRILPQEDMPYLEDGQPVDLVLNP 1145
Cdd:pfam00562  200 --------------------ELPPGGIKMVKVYIRQKRKPEVGDKFASRHGQKGVVSRILPQEDMPFTEDGIPPDIILNP 259
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1146 LGVPSRMNIGQILETHLGWASAGlgkqigraidqyrlamkgrgdaaqtmdglritlkeaygqkvyddqiadmtegellel 1225
Cdd:pfam00562  260 HGVPSRMTIGQLLETHLGKAAAL--------------------------------------------------------- 282
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1226 ggnlrKGVPFATPVFDGARE--EDICQQLEKAGLDRSGQVTLIDGRTGEAFDRKVTVGYIYMLKLHHLVDDKIHARSIGP 1303
Cdd:pfam00562  283 -----LGVFVDATPFDGASTevEDIGELLEKAGYNYYGKEVLYDGRTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGP 357
                          570
                   ....*....|....
gi 1719379330 1304 YSLVTQQPLGGKAQ 1317
Cdd:pfam00562  358 YSLLTRQPLGGRAR 371
PRK08565 PRK08565
DNA-directed RNA polymerase subunit B; Provisional
26-1393 1.29e-86

DNA-directed RNA polymerase subunit B; Provisional


Pssm-ID: 236291 [Multi-domain]  Cd Length: 1103  Bit Score: 307.27  E-value: 1.29e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   26 NLIEVQRSSYDHFLqmdvppekraNLGLQEVFRSVFPIKDFSDRAVLDFVKYELEQPKYDvE-----------ECQQRGM 94
Cdd:PRK08565    13 GLVRQHLDSYNDFI----------ERGLQEIVDEFGEIKTEIPGLKIVLGKIRVGEPEIK-EadgserpitpmEARLRNL 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   95 TFAAPLKVTLRLSVFDVEEdtglrsirdiKEQDVYMGDMPLMTAN------------------------GTFIINGTERV 150
Cdd:PRK08565    82 TYAAPLYLTMIPVENGIEY----------EPEEVKIGDLPIMVKSkicplsglspdelieigedpkdpgGYFIINGSERV 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  151 IVSQMHRSPG---VffdhDKGKTHSSGKYLfaARVIPYRG---SWLDFEFDAKDLVYVRIDR-RRKLPATTLLFALdgae 223
Cdd:PRK08565   152 IVSQEDLAPNrvlV----DKGEAGSSITHT--AKVISSRAgyrAQVTVERRKDGTIYVSFPAvPGKIPFVILMRAL---- 221
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  224 tealraerkaqkkdllpyeaqGMAKEEilnffydtitytrasggwktpfnadrmkgvkvasDLVDAASgqvvaeagtkMT 303
Cdd:PRK08565   222 ---------------------GLETDR----------------------------------DIVYAVS----------LD 236
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  304 PRLIKKLvegglaeqlvsteeltgrylavdiinertgevlfeagdelsasdLDKLEKAGvdelpvlaidhlnvgayirnt 383
Cdd:PRK08565   237 PEIQQEL--------------------------------------------LPSLEQAS--------------------- 251
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  384 maaDRNASREDALIDIYRVMRPGEPPT--LESAEALFaglffdsERYDLSAVGrvkmnarlnfqTEDSVRVLRKQDIMSI 461
Cdd:PRK08565   252 ---SIAATVEDALDYIGKRVAIGQPREyrIERAEQIL-------DKYLLPHLG-----------TSPEDRIKKAYFLGQM 310
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  462 LKVLVNLKDGRGEIDDIDHLGNRRVRSVGELMENQYRVGLLRMERAIRERMSS-------VEIDTVMPHDLINAK--PAA 532
Cdd:PRK08565   311 ASKLLELYLGRREPDDKDHYANKRLRLAGDLLAELFRVAFKQLVKDLKYQLEKsyargrkLDLRAIVRPDIITERirHAL 390
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  533 AAVREFFGSSQLSQFMDQTNPLSEITHKRRLsaLGPggLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYA 612
Cdd:PRK08565   391 ATGNWVGGRTGVSQLLDRTNYLSTLSHLRRV--VSP--LSRGQPHFEARDLHGTQWGRICPFETPEGPNCGLVKNLALMA 466
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  613 RVNQ-----------YGF--------IESPY-----------------------RKVRD----SIVTDEV---------- 636
Cdd:PRK08565   467 QISVgvdeeeveeilYELgvvpveeaREEEYiswsrvylngrligyhpdgeelaEKIRElrrsGKISDEVnvayietgei 546
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  637 --VYLSAmEEGR-----YVVAQANAELDADNRFA--------ADLVscRQGG-EYLMFRPE-----AIDLIDVSPKQ--- 692
Cdd:PRK08565   547 neVYVNC-DSGRvrrplIVVENGKPKLTREHVEKlkkgeltfDDLV--KMGViEYLDAEEEenayvALDPEDLTPEHthl 623
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  693 ------LVSVAAALIPFLENDDANRALMGSNMQRQAVPLVKADAPLvgtgmeatvardsgvtivakrkgivdqidatRIV 766
Cdd:PRK08565   624 eiwppaILGITASIIPYPEHNQSPRNTYQAAMAKQSLGLYAANFRI-------------------------------RTD 672
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  767 VRAtdssdatapgvdiyNLLKFqrsnqntciTQRPLVKVgdRVAagDIIA--DGPStelgelalGRNVLVAFMPWNGYNF 844
Cdd:PRK08565   673 TRG--------------HLLHY---------PQRPLVQT--RAL--EIIGynDRPA--------GQNAVVAVLSYTGYNI 717
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  845 EDSILINERIVKDDVFTSIHIEEFEVMARDTKLGQE-EITRDIPNV----GEEALKNLDEAGIVYIGAEVRPGDILVGKV 919
Cdd:PRK08565   718 EDAIIMNKASIERGLARSTFFRTYETEERKYPGGQEdKIEIPEPNVrgyrGEEYYRKLDEDGIVSPEVEVKGGDVLIGKT 797
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  920 TPkgesP-MTPEEKLLRAIFGEKasdvRDTSLRLPPGVAGTivevrvfsrrgVDKderalaieraeieklakdrdderai 998
Cdd:PRK08565   798 SP----PrFLEELEELSLGLQER----RDTSVTVRHGEKGI-----------VDT------------------------- 833
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  999 lersfytrlkeVILGQTAQSGpkgmkagtvltdaelanltkgqwrqisiadeqvmetveslgkvfddsiqalqnrfenkv 1078
Cdd:PRK08565   834 -----------VLITESPEGN----------------------------------------------------------- 843
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1079 eklqrgdelppgvmKMVKVFVAVKRKLQPGDKMAGRHGNKGVVSRILPQEDMPYLEDGQPVDLVLNPLGVPSRMNIGQIL 1158
Cdd:PRK08565   844 --------------KLVKVRVRDLRIPELGDKFASRHGQKGVIGMLVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLL 909
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1159 ETHLGWASAGLGkqigRAIDqyrlamkgrgdaaqtmdglritlkeaygqkvyddqiadmtegellelggnlrkgvpfATP 1238
Cdd:PRK08565   910 ESIAGKVAALEG----RFVD---------------------------------------------------------ATP 928
                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1239 vFDGAREEDICQQLEKAGLDRSGQVTLIDGRTGEAFDRKVTVGYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQF 1318
Cdd:PRK08565   929 -FYGEPEEELRKELLKLGYKPDGTEVMYDGRTGEKIKAPIFIGVVYYQKLHHMVADKIHARARGPVQILTRQPTEGRARE 1007
                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1319 GGQRFGEMEVWALEAYGAAYTLQEMLTVKSD-------DVSG-------RTKVYEAIVRGDDN--FEAGIPESFNVLVKE 1382
Cdd:PRK08565  1008 GGLRFGEMERDCLIGHGAAMLLKERLLDSSDkttiyvcELCGhiawydrRKNKYVCPIHGDKGniSPVEVSYAFKLLLQE 1087
                         1530
                   ....*....|.
gi 1719379330 1383 LRSLGLNVELN 1393
Cdd:PRK08565  1088 LMSMGISPRLK 1098
rpoB_arch TIGR03670
DNA-directed RNA polymerase subunit B; This model represents the archaeal version of ...
686-1393 1.61e-63

DNA-directed RNA polymerase subunit B; This model represents the archaeal version of DNA-directed RNA polymerase subunit B (rpoB) and is observed in all archaeal genomes.


Pssm-ID: 274713 [Multi-domain]  Cd Length: 599  Bit Score: 228.37  E-value: 1.61e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  686 IDVSPKQLVSVAAALIPFLENDDANRALMGSNMQRQAVPLVKADAPLvgtgmeatvardsgvtivakrkgivdqidatRI 765
Cdd:TIGR03670  119 LEIDPSAILGIIASTIPYPEHNQSPRNTMGAAMAKQSLGLYAANYRI-------------------------------RL 167
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  766 VVRAtdssdatapgvdiyNLLKFqrsnqntciTQRPLVKVgdRVAagDIIadgpstELGELALGRNVLVAFMPWNGYNFE 845
Cdd:TIGR03670  168 DTRG--------------HLLHY---------PQKPLVKT--RVL--ELI------GYDDRPAGQNFVVAVMSYEGYNIE 214
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  846 DSILINERIVKDDVFTSIHIEEFEVMARDTKLGQE-EITRDIPNV----GEEALKNLDEAGIVYIGAEVRPGDILVGKVT 920
Cdd:TIGR03670  215 DALIMNKASIERGLARSTFFRTYEAEERRYPGGQEdRFEIPEPDVrgyrGEEAYKHLDEDGIVYPEVEVKGGDVLIGKTS 294
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  921 PkgesPMTPEEkllRAIFGEKASDVRDTSLRLPPGVAGTivevrvfsrrgVDKderalaieraeieklakdrdderaile 1000
Cdd:TIGR03670  295 P----PRFLEE---LREFGLVTERRRDTSVTVRHGEKGI-----------VDK--------------------------- 329
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1001 rsfytrlkeVILgqtaqsgpkgmkagtvltdaelanltkgqwrqisiadeqvMETVESlgkvfddsiqalqnrfenkvek 1080
Cdd:TIGR03670  330 ---------VII----------------------------------------TETEEG---------------------- 338
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1081 lqrgdelppgvMKMVKVFVAVKRKLQPGDKMAGRHGNKGVVSRILPQEDMPYLEDGQPVDLVLNPLGVPSRMNIGQILET 1160
Cdd:TIGR03670  339 -----------NKLVKVRVRDLRIPELGDKFASRHGQKGVIGMIVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLEM 407
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1161 HLGWASAglgkQIGRAIDqyrlamkgrgdaaqtmdglritlkeaygqkvyddqiadmtegellelggnlrkgvpfATPvF 1240
Cdd:TIGR03670  408 IAGKVAA----LEGRRVD---------------------------------------------------------GTP-F 425
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1241 DGAREEDICQQLEKAGLDRSGQVTLIDGRTGEAFDRKVTVGYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQFGG 1320
Cdd:TIGR03670  426 EGEPEEELRKELLKLGFKPDGKEVMYDGITGEKLEAEIFIGVIYYQKLHHMVADKIHARSRGPVQVLTRQPTEGRAREGG 505
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1321 QRFGEMEVWALEAYGAAYTLQEMLTVKSDDVS-------GRTKVYEAI-------VRGD--DNFEAGIPESFNVLVKELR 1384
Cdd:TIGR03670  506 LRFGEMERDVLIGHGAAMLLKERLLDESDKYVvyvcencGHIAWEDKRkgtaycpVCGEtgDISPVEMSYAFKLLLDELK 585

                   ....*....
gi 1719379330 1385 SLGLNVELN 1393
Cdd:TIGR03670  586 SLGISPRLE 594
PRK07225 PRK07225
DNA-directed RNA polymerase subunit B'; Validated
686-1388 6.78e-59

DNA-directed RNA polymerase subunit B'; Validated


Pssm-ID: 235972 [Multi-domain]  Cd Length: 605  Bit Score: 214.82  E-value: 6.78e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  686 IDVSPKQLVSVAAALIPFLENDDANRALMGSNMQRQAVPLVKADAPLvgtgmeatvardsgvtivakrkgivdqidatRI 765
Cdd:PRK07225   125 LEIDPSLILGIGAGMIPYPEHNASPRITMGAGMIKQSLGLPAANYKL-------------------------------RP 173
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  766 VVRAtdssdatapgvdiyNLLKFqrsnqntciTQRPLVKVgdrvAAGDIIA--DGPStelgelalGRNVLVAFMPWNGYN 843
Cdd:PRK07225   174 DTRG--------------HLLHY---------PQVPLVKT----QTQEIIGfdERPA--------GQNFVVAVMSYEGYN 218
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  844 FEDSILINERIVKDDVFTSIHIEEFEVMARDTKLGQE-EITRDIPNV----GEEALKNLDEAGIVYIGAEVRPGDILVGK 918
Cdd:PRK07225   219 IEDALIMNKASIERGLGRSHFFRTYEGEERRYPGGQEdRFEIPDKDVrgyrGEEAYRHLDEDGLVNPETEVKEGDVLIGK 298
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  919 VTPkgesPMTPEEKllrAIFGEKASDVRDTSLrlppgvagtivevrvfsrrgvdkderalaieraeieklakdrdderai 998
Cdd:PRK07225   299 TSP----PRFLEEP---DDFGISPEKRRETSV------------------------------------------------ 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  999 lersfytrlkevilgqTAQSGPKGMkAGTVLtdaelanltkgqwrqisiadeqVMETVESlgkvfddsiqalqnrfenkv 1078
Cdd:PRK07225   324 ----------------TMRSGEEGI-VDTVI----------------------LTETEEG-------------------- 344
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1079 eklqrgdelppgvMKMVKVFVAVKRKLQPGDKMAGRHGNKGVVSRILPQEDMPYLEDGQPVDLVLNPLGVPSRMNIGQIL 1158
Cdd:PRK07225   345 -------------SRLVKVRVRDLRIPELGDKFASRHGQKGVIGLIVPQEDMPFTESGVVPDLIINPHAIPSRMTVGHVL 411
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1159 EThlgwasagLGKQIGraidqyrlAMKGRgdaaqTMDGlritlkeaygqkvyddqiadmtegellelggnlrkgvpfaTP 1238
Cdd:PRK07225   412 EM--------IGGKVG--------SLEGR-----RVDG----------------------------------------TA 430
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1239 vFDGAREEDICQQLEKAGLDRSGQVTLIDGRTGEAFDRKVTVGYIYMLKLHHLVDDKIHARSIGPYSLVTQQPLGGKAQF 1318
Cdd:PRK07225   431 -FSGEDEEDLREALEKLGFEHTGKEVMYDGITGEKIEAEIFVGVIYYQKLHHMVANKLHARSRGPVQVLTRQPTEGRARE 509
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1319 GGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVS-------GRTKVYEAIVR-------GD--DNFEAGIPESFNVLVKE 1382
Cdd:PRK07225   510 GGLRFGEMERDVLIGHGAAMLLKERLLDESDKVEiyvcakcGMIAIYDKKRNrkycpicGEetDIYPVEMSYAFKLLLDE 589

                   ....*.
gi 1719379330 1383 LRSLGL 1388
Cdd:PRK07225   590 LKSLGI 595
RNA_pol_Rpb2_1 pfam04563
RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. ...
26-530 2.54e-55

RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the protrusion domain. The other lobe (pfam04561) is nested within this domain.


Pssm-ID: 367994 [Multi-domain]  Cd Length: 396  Bit Score: 198.37  E-value: 2.54e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   26 NLIEVQRSSYDHFLQMDVPPEKRANLGLQEVFRSVFPIKDfSDRAVLDFVKYELEQPKYDV----------EECQQRGMT 95
Cdd:pfam04563    1 GLVRQQLDSFNEFVDNDLQKIIDENALIESEFEIQHPGEN-GDKLSLKFGQIRLGKPMFDEtdgstreiypQECRLRNLT 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330   96 FAAPLKVTLRLSVFDVEedtglrsirDIKEQDVYMGDMPLMTAN------------------------GTFIINGTERVI 151
Cdd:pfam04563   80 YSAPLYVDLELSVYNGE---------DIKPIEVFIGRLPIMLRSnacilsgateselvklgecpldpgGYFIINGSEKVI 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  152 VSQMHRS---PGVFFDHDKGKTHSSGKYLFAAR--VIPYRGSWLDF-EFDAKDLVYVRIDRRRK-LPATTLLFALdGAET 224
Cdd:pfam04563  151 VAQEHRSrnhPIVFKKADPKKRGSVASVRSSAEisVRPDSTSWVNVlEYLSNGTIYFKFPYIKKeIPIVIILRAL-GFTS 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  225 EalraerkaqkkdllpyeaqgmakEEILNffydtitytrasggwktpfnadrmkgvKVASDLVDAasgqvvaeagtkmtp 304
Cdd:pfam04563  230 D-----------------------REIFE---------------------------LICYDVNDQ--------------- 244
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  305 rlikklvegglaeQLVsteeltgrylavdiinertgevlfeagDELSASdldkLEKAGVDELPvlaiDHLNVGAYIRNTM 384
Cdd:pfam04563  245 -------------QLQ---------------------------EELLPS----LEEGFKIRIQ----TQEQALDYIGGRG 276
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  385 AAdrnasredalidIYRVMRPGEPPTLESAEALFAGLFFDSERYDLSAVGRVKMnarlnfqtedsvrvlrkqdIMSILKV 464
Cdd:pfam04563  277 RA------------IFRMGRPREPRIKYAEEILQKEVLPHLGTYELDETKKAYF-------------------IGYMIRR 325
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1719379330  465 LVNLKDGRGEIDDIDHLGNRRVRSVGELMENQYRVGLLRMERAIRERMSSV--EIDTVMPHDLINAKP 530
Cdd:pfam04563  326 LLLLALGRREVDDRDHLGNKRLRLAGPLLASLFRVLFKKLVRDVRERLQKVlgSPDDLMLQLLVNAKP 393
RNA_pol_Rpb2_3 pfam04565
RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of ...
546-613 5.73e-38

RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 3, s also known as the fork domain and is proximal to catalytic site.


Pssm-ID: 428011 [Multi-domain]  Cd Length: 67  Bit Score: 136.12  E-value: 5.73e-38
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1719379330  546 QFMDQTNPLSEITHKRRLSAlGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYAR 613
Cdd:pfam04565    1 QVLDRTNYLSTLSHLRRVNS-PRGGLFREMKTTEVRDLHPSHWGRICPVETPEGPNCGLVKHLALYAR 67
RNA_pol_Rpb2_7 pfam04560
RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of ...
1319-1392 1.36e-33

RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain comprised of the structural domains anchor and clamp. The clamp region (C-terminal) contains a zinc-binding motif. The clamp region is named due to its interaction with the clamp domain found in Rpb1. The domain also contains a region termed "switch 4". The switches within the polymerase are thought to signal different stages of transcription.


Pssm-ID: 461355 [Multi-domain]  Cd Length: 87  Bit Score: 124.62  E-value: 1.36e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330 1319 GGQRFGEMEVWALEAYGAAYTLQEMLTVKSD----DVSGRTKVYEA-----IVRGDDNFEAG-IPESFNVLVKELRSLGL 1388
Cdd:pfam04560    1 GGLRFGEMERWALIAYGAAHTLQERLTIKSDayevDVCGRCGLYAAynkcpICKGETDISPGyIPESFKLLFQELQSLGI 80

                   ....
gi 1719379330 1389 NVEL 1392
Cdd:pfam04560   81 DPRL 84
RNA_pol_Rpb2_45 pfam10385
RNA polymerase beta subunit external 1 domain; RNA polymerases catalyze the DNA-dependent ...
624-689 1.41e-30

RNA polymerase beta subunit external 1 domain; RNA polymerases catalyze the DNA-dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared with three in eukaryotes (not including mitochondrial or chloroplast polymerases). This domain in prokaryotes spans the gap between domains 4 and 5 of the yeast protein. It is also known as the external 1 region of the polymerase and is bound in association with the external 2 region.


Pssm-ID: 463067 [Multi-domain]  Cd Length: 66  Bit Score: 115.16  E-value: 1.41e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1719379330  624 YRKVRDSIVTDEVVYLSAMEEGRYVVAQANAELDADNRFAADLVSCRQGGEYLMFRPEAIDLIDVS 689
Cdd:pfam10385    1 YRKVEDGKVTDEIVYLTADEEDGYVIAQANAPLDEDGRFVDERVSARYRGEFPLVPPEEVDYMDVS 66
PRK09606 PRK09606
DNA-directed RNA polymerase subunit B''; Validated
468-616 4.70e-26

DNA-directed RNA polymerase subunit B''; Validated


Pssm-ID: 236587 [Multi-domain]  Cd Length: 494  Bit Score: 113.89  E-value: 4.70e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  468 LKDGRGEIDDIDHLGNRRVRSVGELMENQYRVGLLRM--------ERA-IRERMSSVEidTVMPHDLINA--KPAAAAVR 536
Cdd:PRK09606   320 LALGRREEDDKDHYANKRLKLAGDLMEDLFRVAFNRLardvkyqlERAnMRNRELSIK--TAVRSDVLTErlEHAMATGN 397
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  537 EFFGSSQLSQFMDQTNPLSEITHKRRLSAlgpgGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNQ 616
Cdd:PRK09606   398 WVGGRTGVSQLLDRTDYMATLSHLRRVVS----PLSRSQPHFEARDLHPTQWGRICPSETPEGPNCGLVKNFAQMVEIST 473
RNA_pol_Rpb2_2 pfam04561
RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of ...
389-487 1.20e-11

RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the lobe domain. DNA has been demonstrated to bind to the concave surface of the lobe domain, and plays a role in maintaining the transcription bubble. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 1 (DRI).


Pssm-ID: 398318 [Multi-domain]  Cd Length: 185  Bit Score: 65.06  E-value: 1.20e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  389 NASREDALIDIYRV--MRPGEPPTLESAEALFAglffdserydlSAVGRVKMNARLNFQTEDSVRVLRKQDIMSILKVLV 466
Cdd:pfam04561   96 IYTQEEALDYIGKGfaLRRGEEPRLQRAREILY-----------SRDPKYNLNKHLGLNEPFENERLKAQDILYMIDRLL 164
                           90       100
                   ....*....|....*....|.
gi 1719379330  467 NLKDGRGEIDDIDHLGNRRVR 487
Cdd:pfam04561  165 NLKLGRRKPDDIDHLGNKRVR 185
PRK00566 PRK00566
DNA-directed RNA polymerase subunit beta'; Provisional
286-368 8.07e-09

DNA-directed RNA polymerase subunit beta'; Provisional


Pssm-ID: 234794 [Multi-domain]  Cd Length: 1156  Bit Score: 60.47  E-value: 8.07e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  286 LVDAASGQVVAE------AGTKMTPrlikkLVEGGlaEQLVSTEE-LTGRYLAVDIINERTGEVLFEAGDELSASDLDKL 358
Cdd:PRK00566   767 LVDVAQDVIVREddcgtdRGIEVTA-----IIEGG--EVIEPLEErILGRVLAEDVVDPETGEVIVPAGTLIDEEIADKI 839
                           90
                   ....*....|
gi 1719379330  359 EKAGVDELPV 368
Cdd:PRK00566   840 EEAGIEEVKI 849
RpoC COG0086
DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; DNA-directed RNA ...
286-365 2.91e-04

DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; DNA-directed RNA polymerase, beta' subunit/160 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439856 [Multi-domain]  Cd Length: 1165  Bit Score: 45.54  E-value: 2.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1719379330  286 LVDAASGQVVAEAGTKMTPRL-IKKLVEGG-LAEQLvsTEELTGRYLAVDIINERTGEVLFEAGDELSASDLDKLEKAGV 363
Cdd:COG0086    766 LVDVAQDVIVTEEDCGTDRGItVTAIKEGGeVIEPL--KERILGRVAAEDVVDPGTGEVLVPAGTLIDEEVAEIIEEAGI 843

                   ..
gi 1719379330  364 DE 365
Cdd:COG0086    844 DS 845
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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