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Conserved domains on  [gi|1718055432|ref|WP_144530559|]
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TetR/AcrR family transcriptional regulator [Bacillus subtilis]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
1-154 6.54e-22

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 86.88  E-value: 6.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718055432   1 MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTFFKNKEELFDEIFTTLLKEMKQKADEAVEPNLPFhEN 80
Cdd:COG1309     3 RREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPR-ER 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1718055432  81 VHRALFAILEFRKTHQLTIKIFQENAEIGTmAVQEVIQKMERAILSYIKSKIEDGiksGAIKPCDPELTAFVML 154
Cdd:COG1309    82 LRALLRAYLEFLAENPALARLLLAEAAELP-ELRAALRALLRRLRALLAELLRAG---GLLADVDPDALARALL 151
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
1-154 6.54e-22

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 86.88  E-value: 6.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718055432   1 MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTFFKNKEELFDEIFTTLLKEMKQKADEAVEPNLPFhEN 80
Cdd:COG1309     3 RREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPR-ER 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1718055432  81 VHRALFAILEFRKTHQLTIKIFQENAEIGTmAVQEVIQKMERAILSYIKSKIEDGiksGAIKPCDPELTAFVML 154
Cdd:COG1309    82 LRALLRAYLEFLAENPALARLLLAEAAELP-ELRAALRALLRRLRALLAELLRAG---GLLADVDPDALARALL 151
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
9-55 1.72e-13

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 61.65  E-value: 1.72e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1718055432   9 ILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTFFKNKEELFDEI 55
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 9-55 1.11e-08

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 52.70  E-value: 1.11e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1718055432   9 ILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTFFKNKEELFDEI 55
Cdd:PRK10668   16 ILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEI 62
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
8-73 5.24e-07

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 47.59  E-value: 5.24e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1718055432   8 LILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTFFKNKEELFDEIfttlLKEMKQKADEAVEP 73
Cdd:NF041196   10 AILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAV----LEEQVARLREAVEP 71
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
1-154 6.54e-22

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 86.88  E-value: 6.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718055432   1 MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTFFKNKEELFDEIFTTLLKEMKQKADEAVEPNLPFhEN 80
Cdd:COG1309     3 RREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPR-ER 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1718055432  81 VHRALFAILEFRKTHQLTIKIFQENAEIGTmAVQEVIQKMERAILSYIKSKIEDGiksGAIKPCDPELTAFVML 154
Cdd:COG1309    82 LRALLRAYLEFLAENPALARLLLAEAAELP-ELRAALRALLRRLRALLAELLRAG---GLLADVDPDALARALL 151
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
9-55 1.72e-13

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 61.65  E-value: 1.72e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1718055432   9 ILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTFFKNKEELFDEI 55
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 9-55 1.11e-08

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 52.70  E-value: 1.11e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1718055432   9 ILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTFFKNKEELFDEI 55
Cdd:PRK10668   16 ILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEI 62
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
8-73 5.24e-07

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 47.59  E-value: 5.24e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1718055432   8 LILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTFFKNKEELFDEIfttlLKEMKQKADEAVEP 73
Cdd:NF041196   10 AILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAV----LEEQVARLREAVEP 71
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 5-55 1.04e-06

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 47.04  E-value: 1.04e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1718055432   5 RKKLIlEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTFFKNKEELFDEI 55
Cdd:PRK09975   13 RQELI-ETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEM 62
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 5-153 1.84e-06

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 46.46  E-value: 1.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718055432   5 RKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTFFKNKEELFDEIfttllkeMKQKADEAVEPNLPFHENVhRA 84
Cdd:PRK15008   19 KKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAV-------LRQILDIWLAPLKAFREDF-AP 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1718055432  85 LFAI-------LEFRKTHQLTIKIFQENAEIGTMAVQEVIQKMERAILSYIKSKIEDGIKSGAIKPCDPELTAFVM 153
Cdd:PRK15008   91 LAAIkeyirlkLEVSRDYPQASRLFCMEMLAGAPLLMDELTGDLKALIDEKSALIAGWVKSGKLAPIDPQHLIFMI 166
TetR_C_24 pfam17932
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 79-188 3.02e-05

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.


Pssm-ID: 465574  Cd Length: 114  Bit Score: 41.39  E-value: 3.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718055432  79 ENVHRALFAILEFRKTHQLTIKIFqeNAEIGTM--AVQEVIQKMERAILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKL 156
Cdd:pfam17932   6 ERLRALVRAHVRVHAERRDEAAVF--LRELRSLspEHRAEIRALRREYERLLRDLIEEGVAAGEFRDLDPKLAALAILGM 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1718055432 157 YIAlIFDWEKQHPPLDKETIAGLLELYVVKGL 188
Cdd:pfam17932  84 LNW-VYRWYRPDGPLSPEEIADQYADLLLRGL 114
PRK00767 PRK00767
transcriptional regulator BetI; Validated
 3-67 2.09e-03

transcriptional regulator BetI; Validated


Pssm-ID: 179115 [Multi-domain]  Cd Length: 197  Bit Score: 37.51  E-value: 2.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1718055432   3 IDRKKLIlEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTFFKNKEELFDEIFTTLLKEMKQKA 67
Cdd:PRK00767    9 IRRQQLI-DATLRAIGEVGLLDATIAQIARRAGVSTGIISHYFGGKDGLLEATMRHLLRQLGDAV 72
PRK14996 PRK14996
TetR family transcriptional regulator; Provisional
 5-85 3.46e-03

TetR family transcriptional regulator; Provisional


Pssm-ID: 184958 [Multi-domain]  Cd Length: 192  Bit Score: 36.61  E-value: 3.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1718055432   5 RKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTFFKNKEELFDEIFTTLLKEMkqKADEAVEPNLPFHENVHRA 84
Cdd:PRK14996    9 RREVILQAAMRVALAEGFAAMTVRRIASEAQVAAGQVHHHFSSAGELKALAFIHLIRQL--LDAEQVPQTASWRERLHAM 86


                  .
gi 1718055432  85 L 85
Cdd:PRK14996   87 L 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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