|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
1-376 |
0e+00 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 638.31 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 1 MNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKIDAWWYFAVISVSGVFAVTFSVVFAYVADITQ 80
Cdd:cd17387 37 MNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 81 EHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPASWGAPISWEQAD 160
Cdd:cd17387 117 EEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATIVALLDICFILLAVPESLPEKMRPASWGAPISWEQAD 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 161 PFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKN 240
Cdd:cd17387 197 PFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVMGFEYEEVAAFIAVVGILSITAQTLLLSILMRSIGAKN 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 241 TILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFI 320
Cdd:cd17387 277 TILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISALVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFV 356
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1717019280 321 FYIFHVELDElpITETNSEDKDNLHHSQQNSIIPGPPFLFGACSVLLALLVALFIP 376
Cdd:cd17387 357 FYLFHVDLNE--IKPVQSSKQRMQNPSLEGAIIPGPPFLFGAISVLLAILVASFIP 410
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
1-324 |
1.47e-62 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 205.12 E-value: 1.47e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 1 MNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGVFAVTFSVVFAYVADI 78
Cdd:cd17330 35 YVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLsrNLWLLFLARFLDGLTGGNVSVAQAYIADI 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 79 TQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPeslpekmrpaswgapisweq 158
Cdd:cd17330 115 TDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP-------------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 159 adpfaslkkvgqdsIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGN 238
Cdd:cd17330 175 --------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 239 KNTILLGLGFQILQLAWYGFGSE-PWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALY 317
Cdd:cd17330 241 RKLLRLGLLLAIIGLLLLPFASSvPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLA 320
|
....*..
gi 1717019280 318 GFIFYIF 324
Cdd:cd17330 321 GPLYSFL 327
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
2-333 |
6.27e-43 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 154.72 E-value: 6.27e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 2 NGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLT--------VFFTCAPIplmkidAWWYFAVISVSGVFAVTFSVVFA 73
Cdd:cd17388 40 YGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSlagaaldyLLMAFAPT------LWWLYLGRIIAGITGATGAVAAA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 74 YVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSrEYGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPASwgap 153
Cdd:cd17388 114 YIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLG-EISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAF---- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 154 iSWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQTIVLSLLM 233
Cdd:cd17388 189 -RWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIA 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 234 RSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLG 313
Cdd:cd17388 268 KRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIG 347
|
330 340
....*....|....*....|
gi 1717019280 314 PALYGFIFYIFHVELDELPI 333
Cdd:cd17388 348 PLLFTGIFAASPATWPGLAW 367
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-325 |
2.69e-32 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 125.77 E-value: 2.69e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 1 MNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLL-TVFFTCAPIPLMKIDAWWYFAVISV-SGVF-AVTFSVVFAYVAD 77
Cdd:cd17325 32 QIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLgLLLLAVSTLLFAFATSYWQLLLARFlQGLAsAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 78 ITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEKmrpaswgAPISWE 157
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPP-------NKRAVS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 158 QADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQTIVLSLLMRsIG 237
Cdd:cd17325 185 AARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDR-IG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 238 NKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVA-AMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPAL 316
Cdd:cd17325 264 RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLgLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343
|
....*....
gi 1717019280 317 YGFIFYIFH 325
Cdd:cd17325 344 GGFLYDAFG 352
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-312 |
9.77e-29 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 115.07 E-value: 9.77e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGVF-AVTFSVVFAYVADIT 79
Cdd:COG2814 48 GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALapSLWLLLAARFLQGLGaGALFPAALALIADLV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPASwgapisweqa 159
Cdd:COG2814 128 PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLR---------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 160 dpfASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNK 239
Cdd:COG2814 198 ---GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRR 273
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1717019280 240 NTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGL 312
Cdd:COG2814 274 RLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
3-324 |
2.05e-26 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 109.24 E-value: 2.05e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGVF-AVTFSVVFAYVADIT 79
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFahSPWLFAIALVLTGFGgGLFEPASEAMIADVT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLSrEYGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPaswgapiswEQA 159
Cdd:cd17329 118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA---------EKT 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 160 DPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQTIVlSLLMRSIGNK 239
Cdd:cd17329 188 EILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPV-ARLVERFRLR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 240 NTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYG 318
Cdd:cd17329 267 KILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLgEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGG 346
|
....*.
gi 1717019280 319 FIFYIF 324
Cdd:cd17329 347 LLLDLL 352
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
3-325 |
1.34e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 104.05 E-value: 1.34e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLM-KIDAWWYFAVISV--SGVFAVTFSVVFAYVADIT 79
Cdd:cd06174 34 GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFaFAPSFWLLLLGRFllGLGSGLIDPAVLALIADLF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFIL-VAVPESLPEKMRPaswgAPISWEQ 158
Cdd:cd06174 114 PERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILlLLVVPDPPESARA----KNEEASS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 159 ADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGN 238
Cdd:cd06174 190 KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGR 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 239 KNTILLGLGFQILQLAWYGFGSEPWMMWAAGA-VAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALY 317
Cdd:cd06174 270 KPLLLIGLLLMALGLALLLLAPSLLLLLLLLLlLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLA 349
|
....*...
gi 1717019280 318 GFIFYIFH 325
Cdd:cd06174 350 GFLLAATF 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
3-314 |
2.16e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 102.88 E-value: 2.16e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAP--IPLMKIDAWWYFAVISVSGVF-AVTFSVVFAYVADIT 79
Cdd:pfam07690 35 GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGllLLLFASSLWLLLVLRVLQGLGaGALFPAALALIADWF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVldICFILVAVPESLPEKMRPASWGApISWEQA 159
Cdd:pfam07690 115 PPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL--LAAVLLLLPRPPPESKRPKPAEE-ARLSLI 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 160 DPFASLKKVGQDSIVLLICITVFLSYLpeagqYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNK 239
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFGFAFFG-----LLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGR-LLLGRLSDRLGRR 265
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1717019280 240 NTILLGLGFQIL---QLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGP 314
Cdd:pfam07690 266 RRLLLALLLLILaalGLLLLSLTLSSLWLLLALLLLGFGfGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
3-320 |
2.14e-21 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 95.74 E-value: 2.14e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSD----VWG-RKSFLL-------LTVFFTCAPIPLMKIDAWWYFAVISVsgVFAVTFSV 70
Cdd:COG2211 49 GLILLVARLWDAITDPLIGALSDrtrtRWGrRRPWILigaiplaLSFVLLFTAPDLSPTGKLIYALVTYL--LLGLAYTL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 71 VF----AYVADITQE-HERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNL---VVVLATAIAVLDICFILVAVPeSLP 142
Cdd:COG2211 127 VNipysALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAalgYRLTALIFAVLGLLAFLLTFF-GTK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 143 EKMRPASwgapiswEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSI 222
Cdd:COG2211 206 ERPVPEE-------EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAAL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 223 IAqTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGF--GSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQ---- 295
Cdd:COG2211 279 LG-APLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgPGNLWLLLVLAALAGIgLGAILVLPWAMLADVVDYDEWktgr 357
|
330 340
....*....|....*....|....*...
gi 1717019280 296 ---GVVQGMITGIRGLCNGLGPALYGFI 320
Cdd:COG2211 358 rreGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
1-321 |
1.09e-18 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 86.89 E-value: 1.09e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 1 MNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFavIS-VSGVFAVTFSVVFAYVAD 77
Cdd:cd17331 36 VFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFasSVPMLF--LSrLPSVFMHAMQAAQMVVTD 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 78 ITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICfILVAVPESLPEKMRPASWGAPISWE 157
Cdd:cd17331 114 LTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIV-LVILLIPSNTKSKREKEAKESASPP 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 158 QADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIG 237
Cdd:cd17331 193 SVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFG 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 238 NKNTILLGLGFQILQLAWYGF-GSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPAL 316
Cdd:cd17331 273 ERSLLKLSVALLAIGYLLLAFvTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTI 352
|
....*
gi 1717019280 317 YGFIF 321
Cdd:cd17331 353 GGALL 357
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
3-321 |
1.53e-17 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 83.37 E-value: 1.53e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKIdAWWYFAVI---SVSGVF-AVTFSVVFAYVADI 78
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL-APSFALLLlarALAGLAhGGFWAIAAAYAADL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 79 TQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPASwgapisweq 158
Cdd:cd17324 116 VPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLG--------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 159 adPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQTIVLSLLMRsIGN 238
Cdd:cd17324 187 --LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADR-GGR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 239 KNTILLGLGFQILQLAWYGFGSEPWMMWAAGAV-AAMSSITFPAVSALVSRTAdADQQGVVQGMITGIRGLCNGLGPALY 317
Cdd:cd17324 264 RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLwGLGFFAAHSALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALG 342
|
....
gi 1717019280 318 GFIF 321
Cdd:cd17324 343 GLVL 346
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
3-324 |
2.39e-17 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 83.09 E-value: 2.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLmkidawWYFA------VIS--VSGVFAVTFSVVFAY 74
Cdd:cd17389 67 GLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYAL------WAVSrsftifLLSriVGGISKGNVSLSTAI 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 75 VADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVV------LATAIAVLDICFILVAVPESLPEKMRPA 148
Cdd:cd17389 141 VADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFASFTRSLGEVFfsmpalFALVLALADLLFIFFFLPETLPSNLRRL 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 149 SWGapisweqadpfaslkkvgqdsivllicitVFLSYLPEAG-QYSSFFLyLRQVMEFSPESVAAFIAVLGILSIIAQTI 227
Cdd:cd17389 221 GLV-----------------------------YFLYLFLFSGlEFTLTFL-THQRFQYTSMQQGKMFFFIGIIMALVQGG 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 228 VLSLLmRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIR 306
Cdd:cd17389 271 YVRRI-KPGKEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFaAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLG 349
|
330
....*....|....*...
gi 1717019280 307 GLCNGLGPALYGFIFYIF 324
Cdd:cd17389 350 ALARALGPIVACTVYWLA 367
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
3-320 |
8.37e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 81.44 E-value: 8.37e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKIDAWWYFAVIS--VSGV-FAVTFSVVFAYVADIT 79
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLAlfLLGLgLGLLDVAANPYVAALG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 80 QEHERSMaYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPASwgapiswEQA 159
Cdd:COG0738 126 PETAASR-LNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEE-------EAA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 160 DPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNK 239
Cdd:COG0738 198 GSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGR-FLGGFLLKRFGPV 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 240 NTILLGLGFQILQLAWYGFGSEPWM-MWAAGAVAAMSSITFPAVSALVSRTADADQQGVVqGMITGIRGLCNGLGPALYG 318
Cdd:COG0738 277 RLLRLSALLAAVGLLLALLAPGPWLaLIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIG 355
|
..
gi 1717019280 319 FI 320
Cdd:COG0738 356 FL 357
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
3-320 |
1.43e-16 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 80.35 E-value: 1.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKIDAWWYFAVIS--VSGVFAVTFSVVFAYVADITQ 80
Cdd:cd17390 34 GLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSriPLGIFKHTQSLCKAYLSDLVS 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 81 EHERSMAYGLVSATFAASLVTSPAIGAYLSR-EYGNNLVVVLATAIAVLDICFILVAVPESLpekmrpaswgapisweqa 159
Cdd:cd17390 114 EQERSRVLGRFNAASSLGFILGPVVGGHLAEtDGGFYYVALLCSAIFILNAGLVWFLLSKLW------------------ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 160 DPFAslkkvgqdsIVLLICITVFLSylpeagqYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQTIVLSLLmrSIGNK 239
Cdd:cd17390 176 DLLL---------VRFLMGFSVLLF-------RSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRIL--KLYKN 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 240 NTILLGLGFQILQ---LAWYGFGSEPWMMWAAGA-VAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPA 315
Cdd:cd17390 238 NEYLLLLHSFILLalsLLGLALAPSIWLLVLCLTpLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPL 317
|
....*
gi 1717019280 316 LYGFI 320
Cdd:cd17390 318 LSGLL 322
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
3-326 |
1.50e-16 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 80.74 E-value: 1.50e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLT-------VFFTCAPIPLMKIDAWWYFAVISVSGVFAVTFSVVF-AY 74
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllrallAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARqAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 75 VADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATaiavldICFILVAVPESLPEKMRPASWGAPI 154
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA------LSFLLSALLLLFIRRPPPAAPGESS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 155 SWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAqTIVLSLLMR 234
Cdd:cd06173 191 SLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLG-ALLLGRLSK 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 235 SIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITF-PAVSALVSRTADADQQGVVQGMITGIRGLCNGLG 313
Cdd:cd06173 270 RRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLG 349
|
330
....*....|...
gi 1717019280 314 PALYGFIFYIFHV 326
Cdd:cd06173 350 ALLAGLLADALGL 362
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
8-321 |
4.50e-16 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 78.86 E-value: 4.50e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 8 VKGLLSFLSAPLIGALSDVWGRKSFLLLTVF--------------FTCAPIPlmkidaWWYF---AVISVSGVFAVTFSV 70
Cdd:cd17386 38 MGSIPPLFSSLFLGSWSDRYGRKPPLLMSLVglllsslilvlivyFTTVPSV------WWFYlsaIPLALFGGFTAFLSA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 71 VFAYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVpeslpekmrpasw 150
Cdd:cd17386 112 SFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIALLYILFFL------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 151 gapisweqadpfaslkkvgqdSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAvLGILSIIAQTIVLS 230
Cdd:cd17386 179 ---------------------TLLILLLLAAFLTIFVLSGESDVLYLFVLEKFAWNVKDFSYFST-LGSLIYLTGMLGGV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 231 LLMRSIGNKN---TILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQqgvvQGMITGIRG 307
Cdd:cd17386 237 LLLRCLLKMSdstLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSE----QGKIFSLLS 312
|
330
....*....|....
gi 1717019280 308 LCNGLGPALYGFIF 321
Cdd:cd17386 313 VLESLSPLVASPIY 326
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
15-326 |
1.20e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 68.76 E-value: 1.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 15 LSAPLIGALSDVWGRKSFLLLTVFFTCAPIPL--MKIDAWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAYGLVS 92
Cdd:cd17504 46 VSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLaaFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 93 ATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLdicfILVAVPESLPEKMRPASWGAPISweqadpfaslkkvgqds 172
Cdd:cd17504 126 ATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVL----LAALVPLIDLRLLRRRNVLLANI----------------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 173 IVLLICITVFLSY--LPEAGQYSSFFLYLRQVMEfspesvAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQI 250
Cdd:cd17504 185 TALLAGFGMFMVFqlLPQLLQLPTPTGFGLGITE------AGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISA 258
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1717019280 251 LQLAWYGF-GSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHV 326
Cdd:cd17504 259 VGLLLLALlHSSLWALVVALLLIGIgLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTV 336
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
3-324 |
1.76e-12 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 68.39 E-value: 1.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGV-FAVTFSVVFAYVADIT 79
Cdd:cd17489 34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLatSVALLLVLRLIHGIgWGAFTTAAATLVADII 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDI--CFILVAVPESLPEKMRPASWGapiswe 157
Cdd:cd17489 114 PPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALllVFLVKDPPPVAAEEAEAGTRA------ 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 158 qadPFASLKKVgqdsiVLLICITVFLSYLPEAGqySSFFLYLrQVMEFSPESVAAFIAVLGILSIIAQTIVLSLLMRsIG 237
Cdd:cd17489 188 ---FRRLVEKK-----VLPPALILFLASIAYGA--ISTFLPL-YAAERGISNAGLFFTVYAIALLLSRPFSGKLSDR-KG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 238 NKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPAL 316
Cdd:cd17489 256 PKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLL 335
|
....*...
gi 1717019280 317 YGFIFYIF 324
Cdd:cd17489 336 LGLVAELF 343
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
11-321 |
2.03e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 68.07 E-value: 2.03e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 11 LLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGVF--AVTFSVVFAYVADITQEHERSM 86
Cdd:cd17355 49 LAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALatSLWQLYLLWGLLGGGgaGTLAAVAFATVAAWWFERRRGL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 87 AYGLVSATFAASLVTSPAIGAYLSREYG-NNLVVVLATAIAVLDICFILVAVPESLPEKMRPASWGAPisweqADPFASL 165
Cdd:cd17355 129 ALGILTAGGGLGSLVFLPLGAALIEAFGwRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASP-----ASPGSTL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 166 KKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQvMEFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLG 245
Cdd:cd17355 204 KEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVG-RLLSGWLGDRYSPRRLLAAS 281
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1717019280 246 LGFQILQLAWYGFGSEP-WMMWAAGAVAAMSSI-TFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIF 321
Cdd:cd17355 282 YALRALGLALLLLLPFPpLALLLFAALFGLGWGaTVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLY 359
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
3-325 |
2.35e-12 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 68.26 E-value: 2.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRK-----SFLLLTVFFTCApIPLMKIDAWWYFAVISVSGVFAVTFSVVF--AYV 75
Cdd:COG2270 55 GYALAIAGLLVALLAPVLGAIADRSGRKkpflaFFTLLGVLATAA-LFFVAPGGLWLGLLLFVLANIGFEGSLVFynAFL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 76 ADITQEHER--------SMAY--GLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEKM 145
Cdd:COG2270 134 PDIATPEEIgrvsglgwALGYlgGVLLLLINLALFLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLPERPRPGP 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 146 RPASWGAPISWEQAdpFASLKKVGQDSIVL--LICITVFLSYLpeAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSII 223
Cdd:COG2270 214 APPRGAVRAGFREL--RRTLRELRRYRDLLrfLLAYFFYRDGV--QTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAAL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 224 AqTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVS-ALVSRTADADQQGV----- 297
Cdd:COG2270 290 G-ALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSrSLLARLIPPGREAEffgly 368
|
330 340
....*....|....*....|....*....
gi 1717019280 298 -VQGMITGIrglcngLGPALYGFIFYIFH 325
Cdd:COG2270 369 aLSGKAASF------LGPLLFGLVTQLTG 391
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
3-321 |
3.52e-12 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 67.60 E-value: 3.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCAPIPLMKIDAWWYFAVISV-SGVFA-VTFSVVFAYVADIT 79
Cdd:COG2223 43 GLLFAIPVLVGALLRIPLGFLVDRFGpRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLlLGIGGgGSFAVGIALVSKWF 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLSREYG-NNLVVVLATAIAVLDICFILVAvpESLPEKMRPASwgapisweq 158
Cdd:COG2223 123 PPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGwRNAFLILGILLLVVAVLAWLFL--RDPPAGAAAAA--------- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 159 ADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGN 238
Cdd:COG2223 192 KASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALG-RPLGGWLSDRIGG 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 239 KNTILLGLGFQILQLAWYGF--GSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPAL 316
Cdd:COG2223 271 RRVLLIVFALMALGLLLLALalGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLL 350
|
....*
gi 1717019280 317 YGFIF 321
Cdd:COG2223 351 FGALL 355
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-325 |
5.23e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 66.82 E-value: 5.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGVF-AVTFSVVFAYVADIT 79
Cdd:COG2271 48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFatSFWQLLLLRFLLGLGeAGFFPAALKLIAEWF 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLdicfilvavpeslpekmrpasWGAPISWeqa 159
Cdd:COG2271 128 PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLL---------------------LALLRFW--- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 160 dpfaslkkvgqdsivlLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIG-- 237
Cdd:COG2271 184 ----------------LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVG-SLLGGWLSDRLGrr 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 238 NKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSI-TFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPAL 316
Cdd:COG2271 247 RKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGgAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLL 326
|
....*....
gi 1717019280 317 YGFIFYIFH 325
Cdd:COG2271 327 VGYLLDATG 335
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
3-320 |
6.92e-12 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 66.45 E-value: 6.92e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLL-----TVFFTCAPIPLMKIdAWWYFAVISVSGVF-AVTFSVVFAYVA 76
Cdd:cd17335 35 GILIGIRPFVRFLSAPLWGALADRFGKRKALLLlsllaAVLFFLSLFFVAQI-FWLLLLLVILGAFFsAPVVPLVDSITL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 77 DITQEHERSmaYGLV----SATFAAslvTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVpeslpeKMRPASWGA 152
Cdd:cd17335 114 QYLGEERER--YGKQrlwgSIGFGI---AALLVGILIDRSSTYKNYTIAFYVFAVLMLLALLLAL------KFPFRPKHP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 153 PISWEQADPFASLKKVGqdsiVLLICITVFLSYLPEAGQYSSFFLYLRQVMefSPESVAAFIAVLGILSIIAQTIVLSLL 232
Cdd:cd17335 183 EPNENTGGLLALLRNPR----VLAFLLVAFLMGFGHGLIYSFLFWHLQDLG--GSKTLIGLLWTVGVVSEIPFFFFSSRL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 233 MRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMwaaGAVAAMSSITFPAV----SALVSRTADADQQGVVQGMITgirGL 308
Cdd:cd17335 257 IQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLV---LPIELLHGLTFALVwaaaVSYASAAAPPGLRATAQGLLQ---GL 330
|
330
....*....|..
gi 1717019280 309 CNGLGPALYGFI 320
Cdd:cd17335 331 YFGLGGGLGSLI 342
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
15-324 |
2.42e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 64.90 E-value: 2.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 15 LSAPLIGALSDVWGRKSFLL--LTVFFTCAPIPLMKIDAWWYFAVISVSGV-FAVTFSVVFAYVADITQEHERSMAYGLV 91
Cdd:cd17474 49 VLMPVAGVLADRFGRKKVLLpgLLLFGIGGLLCGLSDSFALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLY 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 92 SATFAASLVTSPAIGAYLSrEYGNNLVVVLATAIAVLDICFILVAVPESlPEKMRPASWGAPISWEQADPFASLKKVGQD 171
Cdd:cd17474 129 EAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPVAFLAILFLLPEP-KEKAKSSSATKLRDLKKALRGRGLLTFLVS 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 172 SIVLLICITVFLSYLPeagqyssffLYLRQVMEFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQIL 251
Cdd:cd17474 207 AFLYFFLYFAFLTYLP---------FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYAL 277
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1717019280 252 QLAWYGFGSEPWMMWAAGAVAAMSS-ITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 324
Cdd:cd17474 278 SLLLLGFVPSLALLLIAIVLFGLGLgLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIF 351
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-137 |
3.90e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 64.13 E-value: 3.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 1 MNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGV-FAVTFSVVFAYVAD 77
Cdd:cd17325 236 QIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLatSFWLLLLLLALLGLgLGLVFPATLALLAD 315
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 78 ITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAV 137
Cdd:cd17325 316 IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
3-327 |
2.48e-10 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 61.79 E-value: 2.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCAPIPLMKIDAWWYFAVISVS------GVFAvtfSVVFAYV 75
Cdd:cd17370 37 GLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRIlerlgkGIRT---PPRDALL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 76 ADITQEHERSMAYGLVSA--TFAAslVTSPAIGAYLSREYGNN--LVVVLATAIAVLDICFILVAVPESlPEKMRPaswg 151
Cdd:cd17370 114 ADATPPSGRGKAFGLHRAldTLGA--VLGPLLAALLLYLLGGNyrTIFLLAAIPALLALLILLFVVKEY-PRPPKL---- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 152 apiswEQADPFASLKKVGQDSIVLLICITVFlsylpEAGQYS-SFFLYLRQVMEFSPESVAAFIAVLGILSIIAqTIVLS 230
Cdd:cd17370 187 -----RKKSKKTSLKKLPKAFWLYLLAVALF-----ALGNFSfAFLILRAQELGLSAALIPLLYALFNLVYALA-AYPAG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 231 LLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTADADQQGVVQGMITGIRGLC 309
Cdd:cd17370 256 RLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTAYGLFNTVVGIG 335
|
330
....*....|....*...
gi 1717019280 310 NGLGPALYGFIFYIFHVE 327
Cdd:cd17370 336 WLLASLIAGYLWDLISPS 353
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
19-321 |
3.36e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 61.44 E-value: 3.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 19 LIGALSDVWGRKSFLL--LTVFFTCAPIPLMKIDAWWYFAVISVSGVFAVTFSVV-FAYVADITQEHERSMAYGLVSATF 95
Cdd:cd17320 53 LYGPLSDRFGRRPVLLagLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVaRAIVRDLYSGAELAKIFSLLMMIL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 96 AASLVTSPAIGAYLSREYGNNLVVVLATAIAVLdiCFILVA--VPESLPEKMRPASWGApisweqadPFASLKKVGQDSI 173
Cdd:cd17320 133 AIAPALAPLLGGLLLLFFGWRAIFVFLALLGLL--LLLLVLlfLPETLPEEKRKPLLSS--------LLRAYKRVLKNRR 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 174 VLL------ICITVFLSYLPEAGqyssfFLYLrQVMEFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLG 247
Cdd:cd17320 203 FLGyalalgLSFAGLFAYLAAAP-----FIYI-EQLGLSPAQFGLLFALNAIALILG-SLLNGRLVRRFGPRRLLRLGLL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 248 FQI------LQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRtADADQQGVVQGMITGIRGLCNGLGPALYGFIF 321
Cdd:cd17320 276 LLLaaalvlLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALE-PFPHVAGTASALLGFLQFLIGALAGALVGLLP 354
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
18-322 |
7.05e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 60.26 E-value: 7.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 18 PLIGALSDVWGRKSFLL--LTVFFTCAPIPLMKIDAWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLVSAT 94
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLigLALFGLASLLCALAPSLAFLIAARALQGIGaAAIMPASLALIAATFPGERRGRALGLWGAV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 95 FAASLVTSPAIGAYLSREYGNNLVVVLATAIAVldICFILVavpeslpekmrPASWGApisweqadpfaslkkvgqdsiv 174
Cdd:cd17321 129 VGIGAALGPLLGGLLLELFGWRWIFLINVPIGL--VALLLA-----------RTFSGA---------------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 175 lliCITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLA 254
Cdd:cd17321 174 ---VLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVA-APLAGRLADRFGPRLVLVAGLLLTAVGLL 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1717019280 255 WYGFGSEPWMMWAAGAVAAMSSI----TFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFY 322
Cdd:cd17321 250 LLALLGADSSVWLLLPGLVLLGLglglFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLT 321
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
15-303 |
1.69e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 59.12 E-value: 1.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 15 LSAPLIGALSDVWGRKSFLL--LTVFFTCAPIPLMKIDAWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGLV 91
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIagLLLYGIGGVAGLFLDSLYALLASRALLGIGvAGIMTLATALIGDYFEGEERAKMLGLQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 92 SATFAASLVTSPAIGAYLSrEYGNNLvVVLATAIAVldICFILVAVpeSLPEKMRPASwgapiswEQADPFASLKKVGQD 171
Cdd:cd17473 130 SAAMSLGGVVFLLLGGALA-EIGWRA-PFLVYLLAL--PVLILVLL--FLPEPARKSK-------SAASPGAATAAALPW 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 172 SIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQIL 251
Cdd:cd17473 197 KRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIG-ALLFGRLKRRLGKRRLLAIGFALMAL 275
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1717019280 252 QLAWYGFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMIT 303
Cdd:cd17473 276 GFLLLALASGLWVVLLGAILAGLgFGLLLPTLNSWAMSLVPPELRGRAMGIVT 328
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
3-324 |
9.74e-09 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 56.48 E-value: 9.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRK-------SFLLLTVFFTCAPIPLMKIdAWWYFAVISV-----SGVFAVTFSV 70
Cdd:pfam12832 37 GLITAILPLTRILAPPIWGWLADRTGKRkavvrlaSILAAVLFLSVLFIPISLT-FWWLALLVVLfsffwNAILPQFEVA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 71 VFAYVADITQEHERSMAYGLVSatFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDicfilVAVPESLPEKMRPASW 150
Cdd:pfam12832 116 TLQHLGEKRKDYGRQRLWGSVG--FALSVFGLGALFDHYSVGLLPSVLFYLFAALMLLS-----LLLPLAPPEMEYESKG 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 151 GapisweqadPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVmEFSPESVAAFIAVlGILSIIAQTIVLS 230
Cdd:pfam12832 189 G---------SKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENL-GASNTLLGALWAL-GVVAEIPLFFYAH 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 231 LLMRSIGNKNTILLGLGFQILQLAWYGFGSE-PWMMWAAGAVAAMSSITFPAVSA-LVSRTADADQQGVVQGMITGIR-G 307
Cdd:pfam12832 258 RLLRRFGHRNLLIIALLLTALRWLLYAFFVEnPWLVLPIQFLHAISFGLTHAAAIeYVRRIFPGSLQGTGQALYSGLYfG 337
|
330
....*....|....*..
gi 1717019280 308 LCNGLGPALYGFIFYIF 324
Cdd:pfam12832 338 LGGALGSLIGGQLWDLF 354
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
3-321 |
9.89e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 56.84 E-value: 9.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLL-SFLSAPLiGALSDVWGRKSFLL--LTVFFTCAPIPLMKIDAWWYFAVISVSGVFAVTfSVVFAYVADIT 79
Cdd:cd17472 35 GLALGIYGLTqAIFQIPF-GLLSDRIGRKPVILfgLLLFIAGSLLAAYATSIYGLILGRALQGSGAIS-SVVMALLADLT 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPASWGapisweqa 159
Cdd:cd17472 113 REENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEK-------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 160 dpfASLKKVGQDSIVLLICITVFLSYLpeagQYSSFFLYLRQVME------------FSPESVAAFIAVlGILSIIAQ-- 225
Cdd:cd17472 185 ---KKLKKLLKNKRLLRLDFSIFILHF----VLMAFFYILPLLLTqlgggkgqlwkvYLPAILIGFILM-VPFVIYAEkk 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 226 TIVLSLLMRSIgnkntILLGLGFQILqlawyGFGSEPWMMWAAGAVAAMSSITF--PAVSALVSRTADADQQGVVQGMIT 303
Cdd:cd17472 257 GKMKQVFVSSI-----LLIAVGFLLL-----LFAATSLWLLIIGLIIFFIGFNLleALLPSLVSKIAPKEYRGTAMGIYN 326
|
330
....*....|....*...
gi 1717019280 304 GIRGLCNGLGPALYGFIF 321
Cdd:cd17472 327 TSQFLGSFLGGALGGLLW 344
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
15-321 |
2.68e-08 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 55.69 E-value: 2.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 15 LSAPLIGALSDV----WGR-KSFLLLT----VFFTCA----PIPLMKIDAWWYFAVISVSGVFAVTFSVVF-AYVADITQ 80
Cdd:cd17332 50 INDPLMGYLIDRtrsrWGRfRPWLLWGaiplALLFVLlfttPDGSGTGKLIYALITYILLDLLYTLVNIPYtALIPELTD 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 81 E-HERS--MAYGLVSATFAASLVTS--PAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESlpEKMRPASWGAPIS 155
Cdd:cd17332 130 DpEERTslTSWRMFFATIGGLLVTVlpPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICFFGT--RERVVPPEEEKSK 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 156 WEQADPFASLKKvgQDSIVLLICITVFLSYLPEAGQySSFFLYLRQVMEFSPESVAAFIAVLGILSIIaqTIVLSLLMRS 235
Cdd:cd17332 208 LPLLKSLKALLK--NRPFLILLLAYLLYFLAFNIVN-TVLVYYFKYVLGGRAELVLLLLLILSGALLA--LLPWPPLKKR 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 236 IGNKNTILLGLGFQILQLAWYGFGSEP--WMMWAAGAVAAM-SSITFPAVSALVSRTADADQ--QGV-VQGMITGIRGLC 309
Cdd:cd17332 283 FGKKKAFFIGLLLAILGLLLLFFLPPGnlVLILVLAVLAGIgYGGANLLPWAMLADVIDYGElkTGKrREGIFYSVMTFF 362
|
330
....*....|..
gi 1717019280 310 NGLGPALYGFIF 321
Cdd:cd17332 363 RKLGLALAGALV 374
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
11-128 |
2.83e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 52.16 E-value: 2.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 11 LLSFLSAPLIGALSDVWGRKSFLLLT-VFFTCAPIPLM-KIDAWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMA 87
Cdd:cd17370 245 LVYALAAYPAGRLSDRIGRKKLLILGyLSLALAYLGFAlGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTA 324
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1717019280 88 YGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVL 128
Cdd:cd17370 325 YGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALI 365
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-139 |
4.30e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.41 E-value: 4.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI----DAWWYFAVISVSGVFA-VTFSVVFAYVAD 77
Cdd:COG2271 219 GLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLallpSPALAIALLFLAGFGLgGAFGLLWALAAE 298
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1717019280 78 ITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPE 139
Cdd:COG2271 299 LFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
177-324 |
4.55e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 51.66 E-value: 4.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 177 ICITVFLSYLPEAGqYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQLAWY 256
Cdd:cd06174 1 LLLGFFLTGLARGL-ISPLLPALLQSFGLSASQLGLLFALFSLGYALLQ-PLAGLLADRFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1717019280 257 GFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 324
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLgSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL 147
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
173-325 |
1.03e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 50.36 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 173 IVLLICITVFLSYLpEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQ 252
Cdd:COG2814 11 ALLALALGAFLSGL-GIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1717019280 253 LAWYGFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFH 325
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
3-237 |
1.03e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 50.19 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGVF-AVTFSVVFAYVADIT 79
Cdd:COG0477 52 GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLapSPELLIAARALQGIGaGGLMPGALALIAELF 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDIcFILVAVPESLPEKMRPASWGAPISWEQA 159
Cdd:COG0477 132 PARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLAL-VLRLRLPESRGLLLALLALALAALLLAA 210
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1717019280 160 DPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIG 237
Cdd:COG0477 211 LALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLL 288
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
18-325 |
1.10e-06 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 50.39 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 18 PLIGALSD----VWGR-KSFLLL---------TVFFTCAPIPLMKIDAWWYFAVISVSgvFAVTFSVV--FAYVADITQE 81
Cdd:pfam13347 51 PIVGHIIDrtrtRWGRrRPWLLLsaiilavsfILLFTPPELGRAPLFIWLLATYILLR--IAYTFFEIpyWSLGPELTRD 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 82 -HERS---------MAYGLVSATFAASLVTSPaIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPASWG 151
Cdd:pfam13347 129 yDERTsltsyrsffSVGGGLLAAALAFPLVLI-LGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQ 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 152 ApiswEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFspESVAAFIAVLGILSIIAQTIVLSL 231
Cdd:pfam13347 208 K----EAGSLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGN--GFAASAFPLVFTIGALLGIPLWPP 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 232 LMRSIGNKNTILLGLGFQI--LQLAWYGFGSEPWMMWAAGAVAAMSSIT-FPAVSALVSRTADADQ---QGVVQGMITGI 305
Cdd:pfam13347 282 LAKRIGKKNTYILGALITIagFALALLLGPNNTLLFLVLYIIIGFGYGSsFFLPWSMLADVVDYGElrtGKRREGTFFAM 361
|
330 340
....*....|....*....|....
gi 1717019280 306 RGLCN----GLGPALYGFIFYIFH 325
Cdd:pfam13347 362 WSFISklatGVGLGVSGLLLSAFG 385
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
3-149 |
1.74e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 49.88 E-value: 1.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRK-----SFLLLTVFftCAPIPLMKIDAWWYFAVISVSGVFA-VTFSVVFAYVA 76
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIGGRrvlliVFALMALG--LLLLALALGSLWLFLVLFLLLGLALgGGNGAVFALVP 321
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1717019280 77 DITQEHERSMAYGLVSATFAASLVTSPAIGAYLsREYGNNLVVVLATAIAVLDICFILVAVpesLPEKMRPAS 149
Cdd:COG2223 322 DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL-LDATGSYTAAFLVFAVLALVALVLTLL---LYRRPRRAA 390
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
1-324 |
4.48e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 48.37 E-value: 4.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 1 MNGLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGVFA---VTFSVVFAy 74
Cdd:cd17490 32 MIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILfpSPWGLLIARFLSGIAAatwVSFTVLYA- 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 75 vaDITQEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPASWgapi 154
Cdd:cd17490 111 --SYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTEL---- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 155 sweqadpfASLKKVGQDSIVLlicitvFLSYLPEAGQYSSFflylRQVMEFSP---ESVAAFIAVLGILS-------IIA 224
Cdd:cd17490 185 --------KELLSVLKDKKLL------FFSLLAILQQMITF----STTFGFTPliaKQLGASSFQLGLLSiiyllpnALA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 225 QTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSS-ITFPAVSALVSRTADADQQGVVQGMIT 303
Cdd:cd17490 247 SLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTgILFPLLMSLSIEGVPAEQRSTAMGFFQ 326
|
330 340
....*....|....*....|.
gi 1717019280 304 GIRGLCNGLGPALYGFIFYIF 324
Cdd:cd17490 327 AIYALGMFLGPVLVGIISEAF 347
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
3-320 |
6.16e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 48.03 E-value: 6.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGVFAVTFSVVFAYVADITQ 80
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFvtNVWQLLILRLLQGVFSGYVPNATALIASQTP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 81 EHERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIavLDICFILVAVpeSLPEKMRPASWGAPISWEQAd 160
Cdd:cd17391 119 KEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGL--LFLAFLLTLF--FVKEDFKPVEKKKMVSTKEV- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 161 pfasLKKVGQDSIVLLICITVFLSylpeagQYSSFF------LYLRQVMefSPESVAAFIA-----VLGILSIIAqTIVL 229
Cdd:cd17391 194 ----WNSVPNPSLLISLFVTTFII------QLANQSiepiltLYIRQLM--GDASNLAFISglvfsATGVSSLLS-APRL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 230 SLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPW-MMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGL 308
Cdd:cd17391 261 GKLGDRIGHHRILLGALLASALLYIPQAFVQTPWqLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYL 340
|
330
....*....|..
gi 1717019280 309 CNGLGPALYGFI 320
Cdd:cd17391 341 GNVAGPLLGSAI 352
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
177-324 |
7.08e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.80 E-value: 7.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 177 ICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQLAWY 256
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-PLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1717019280 257 GFGSEPWMMWAAGAVAAM-SSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 324
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF 148
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
19-265 |
1.47e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 46.77 E-value: 1.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 19 LIGALSDVWG-RKSFLLLT-VFFTCAPIPLMKIDAWWYFAVISV--SGVFAVTFSVVFAYVADITQEH---ERSMAYGLV 91
Cdd:cd17471 51 WLGRLSDRGGdRKPLILLAlLAGALGYLLFAFLRNYWVLLLVGVvlLSLGAAAFPQLFALAREYADRSsgrDATLFNSVL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 92 SATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLdicfILVAVPESLPEKMRPAswgapiswEQADPFASLKKVGQD 171
Cdd:cd17471 131 RAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLV----VALLVLFLLPSVKPPA--------QKATPASSLVKAPVN 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 172 SIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFsPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQIL 251
Cdd:cd17471 199 RRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGG-SESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVL 277
|
250
....*....|....
gi 1717019280 252 QLAWYGFGSEPWMM 265
Cdd:cd17471 278 FYLGLALATSLWQL 291
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
7-134 |
2.32e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 46.06 E-value: 2.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 7 GVKGLLSFLSAPLIGALSDVWGRK---SFLLLTVFFTCAPIPLMKIDAWWYFAVISVSGV-FAVTFSVVFAYVADITQEH 82
Cdd:cd17353 256 SILSIFNGGGRPFWGWLSDKIGRKntlSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFcYGGGFALFPALTADFFGTK 335
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1717019280 83 ERSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFIL 134
Cdd:cd17353 336 NAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALAL 387
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
3-321 |
2.71e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 46.02 E-value: 2.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGV-FAVTFSVVFAYVADIT 79
Cdd:COG2807 56 GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLapSVALLLAGTALIGAgIAVGNVLLPGLIKRWF 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 80 QEHeRSMAYGLVSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESlpekmRPASWGAPISWeqa 159
Cdd:COG2807 136 PDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRR-----PAAAAAAPAAA--- 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 160 dpfaSLKKVGQDSIVLLICITVFLSylpeAGQYSSFFLYLRQVME---FSPESVAAFIAVLGILSIIAQTIVLSLLMRSI 236
Cdd:COG2807 207 ----SLRSLWRSPLAWLLTLFFGLQ----SLLYYAVVAWLPPILRdagLSAATAGLLLSLFQLAGIPGSLLVPLLADRLG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 237 GNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVS-RTADADQQGVVQGMITGIRGLCNGLGPA 315
Cdd:COG2807 279 DRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGlRARTPAEAAALSGMAQSVGYLLAALGPL 358
|
....*.
gi 1717019280 316 LYGFIF 321
Cdd:COG2807 359 LVGALH 364
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
173-324 |
3.50e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 45.63 E-value: 3.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 173 IVLLICITVFLSYLPEAGqYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQ 252
Cdd:COG2271 11 ILALLFLAYFLNYLDRSN-LSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQ-IPAGLLADRFGRRRVLAIGLLLWGLA 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1717019280 253 LAWYGFGSEPWMMWAA-GAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIF 324
Cdd:COG2271 89 TLLFGFATSFWQLLLLrFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
1-279 |
3.61e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 45.63 E-value: 3.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 1 MNGLIQGVKGLLSFLSAPLIGALSDVWG-RKSFLLLTVFFTCAPIPLM-KIDAWWYFAVISVSGVFAVTFSVVF-AYVAD 77
Cdd:cd17477 32 LIGLVASAYYLGILLGSPLVPRLIRRVGhIRAFAAGAAITAVSVLLLAlTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 78 ITQEHERSMAYGLVSATFAASLVTSPAIGAYLSreygnnlvVVLATAIAVLDICFILVAVPESLpekmrpaSWGAPISWE 157
Cdd:cd17477 112 LATNENRGRVLGLYSTVLGLGFALGPLLLALVG--------TAGALPFLIAAVLLLLALVPLLL-------TRRAAPEIE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 158 QADPFASLKKVgqdSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMeFSPESVAAFIAVLGILSIIAQTIVLSLLMRSIG 237
Cdd:cd17477 177 EAESISLRRLL---RIAPLALLGAFVAGFLEGAFYSLLPLYGLRLG-LSVAQAALLLAAFVLGGLLLQWPLGWLADRFDR 252
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1717019280 238 NKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITF 279
Cdd:cd17477 253 RRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPL 294
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
3-275 |
1.18e-04 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 43.75 E-value: 1.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRK-----SFLLLTVFFTCAPIpLMKIDAWWYFAVISVSGVFAVTFSVVF--AYV 75
Cdd:cd17482 42 GYANSIASLVIALLAPILGAIADYSGRKkrflaFFCLIGVVSTALLF-FVTPGQWLLALLLFILANIGFSGANVFydAFL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 76 ADITQEHER----SMAYGLvsATFAASLVTSPAIGAYLSREYGNnlvvvLATAIAVlDICFILVAVpeslpekmrpasWG 151
Cdd:cd17482 121 PDVASPERMdrvsSLGYAL--GYIGGGLLFAVNLVLILGPDAFG-----LDTAEAV-RLSFLSVAL------------WW 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 152 APISweqadpfASLKKVGQDSIVLLICI----TVFLSylpeAGQYSSfflylrQVMEFSPESVAAFIAVLGILSIIAqTI 227
Cdd:cd17482 181 ALFS-------IPLKQLLLFLIAYFFYIdgvqTIIRM----ATIYGA------EEGKLGSSALILALLLTQFVAFPG-AL 242
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1717019280 228 VLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMS 275
Cdd:cd17482 243 LFGWLAERFGAKRAILVSLVIYILICIYAYFMLTAWDFWILAALIGLV 290
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
11-278 |
1.49e-04 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 43.64 E-value: 1.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 11 LLSFLSaPLIGALSDVWGRKSF----------LLLTVFFTCAP--IPLMKIDAWW--YFAVISVSGVFAVTFSVV----F 72
Cdd:cd06176 47 LVAPLR-VWIGHRSDTHPLRGYrrtpyiwlgmLLLALGLALAPfaALLLAGAAFWlgLALAVLAFLLYGIGVGAAgtafL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 73 AYVADITQEHERSMAYGLV-SATFAASLVTSPAIGAYLsREYGNNLVVVLATAIAVLDICFILVAVPESlpEKMRPASWG 151
Cdd:cd06176 126 ALLADLTPEERRPRAVTVVwTMLILGIIVTAIVFGRLL-DPYSPERLIQVFQIVALVALLLALLALWGV--ERRRSRAAL 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 152 APISWEQADPFASLKKVGQDSIVLLICITVFLSYLpeagqysSFFL-------YLRQVMEFSPESVAAFIAVLGILSIIA 224
Cdd:cd06176 203 AAEEAPPETFREALRLLWASPQARRFFIFLFLSTL-------ALFMqdvilepFGGEVFGMSVGETTRLTAIWGGGTLLG 275
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 225 QTIVLSLLMRSIGNKNTILLGLGFQILQ---LAWYGFGSEPWM-------------MWAAGAVAAMSSIT 278
Cdd:cd06176 276 MLLAGFLLSRRLGKKRTAALGCLLSALGfllLALAGLLGNPWLfrpgvfllglgngLFTVGALTLMMDLT 345
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
2-319 |
1.76e-04 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 43.37 E-value: 1.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 2 NGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGVFAVTFSVVFAYVADIT 79
Cdd:PRK09874 56 SGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLaqNIWQFLILRALLGLLGGFVPNANALIATQV 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 80 QEHERSMAYGLVSATFAASLVTSPAIGAYLSREYGnnLVVVLATAIAVLDICFILVAVpeSLPEKMRPASWGAPISWEQA 159
Cdd:PRK09874 136 PRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYG--LRPVFFITASVLFLCFLVTLF--CIRENFQPVSKKEMLHMREV 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 160 dpFASLKkvgQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMefSPESVAAFI-----AVLGILSIIAQTiVLSLLMR 234
Cdd:PRK09874 212 --VTSLK---NPKLVLSLFVTTLIIQVATGSIAPILTLYVRELA--GNVSNIAFIsgmiaSVPGVAALLSAP-RLGKLGD 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 235 SIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAG-AVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLG 313
Cdd:PRK09874 284 RIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRfLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTG 363
|
330
....*....|...
gi 1717019280 314 P-------ALYGF 319
Cdd:PRK09874 364 PlmgaaisANYGF 376
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
1-103 |
2.78e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.79 E-value: 2.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 1 MNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVF------FTCAPIPLMKIDAWWYFAVISVSGVFAVTFSVVFAY 74
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLllilaaLGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNAL 315
|
90 100
....*....|....*....|....*....
gi 1717019280 75 VADITQEHERSMAYGLVSATFAASLVTSP 103
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
14-320 |
4.64e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.20 E-value: 4.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 14 FLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGL 90
Cdd:cd17316 50 PIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLlpTPILLLVLRFLQGIGiGGEYPGASTYVAEFAPSKRRGFALGL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 91 VSATFAASLVTSpaigaylsreygnNLVVVLATAIAVLD----ICFILVAVPESLPEKMRPASWGAPISWeqadpfaslk 166
Cdd:cd17316 130 LQSGWALGALLA-------------ALVASLLIPLLSGDwgwrILFLIGALPALLALLLRRRTLLLILLW---------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 167 kvgqdsIVLLICITVFLSYLPEagqyssfflYLRQVMEFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGL 246
Cdd:cd17316 187 ------FFISFGYYGLTTFLPT---------YLQTVLGLSPATSSLYLLLISLGALVG-ALIAGLLSDRIGRKKTLVIGL 250
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1717019280 247 GFQILQLAWYGF---GSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFI 320
Cdd:cd17316 251 ILSGILALPLFYllsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
11-326 |
5.11e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 41.78 E-value: 5.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 11 LLSFLSAPLIGALSDVWGRKSFLLL-TVFFT-----CAPIPLMkidaWWYFAVISVSGVFA-VTFSVVFAYVADITQEHE 83
Cdd:cd17502 41 LTSTAFQPIYGKLSDLFGRKWVLLIaIVIFElgsllCGLAPNM----TMLIVGRAIQGIGGgGLMSLAFIIIADLVPPRE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 84 RSMAYGLVSATFAASLVTSPAIGAYLSREYGN------NLVVVLATAIAVLDICFILVAvpeslpekmrpaswgapiswe 157
Cdd:cd17502 117 RGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWrwcfyiNLPIGGLALALLRTILLSSIF--------------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 158 qadpfaslkkvgqdSIVLLICITVFLSYLPeagqyssffLYLRQVMEFSPeSVAAFIAVLGILSIIAQTIVLSLLMRSIG 237
Cdd:cd17502 176 --------------GFLFGGALFGLIYYLP---------LYFQLVLGDSA-TKSGVRLLPLIIGLVIGSIISGALISKTG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 238 N-KNTILLGLGFQI---LQLAWYGFGSEPWMMWAAGAVAAMSS-ITFPAVSALVSRTADADQQGVVqgmiTGIRGLCNGL 312
Cdd:cd17502 232 RyKPLIVIGTILMSvgaGLLTTLTLDTSKWLLIGYLILLGLGLgIGFQQPLVAVQNAVPPADVGVA----TATNTFFRSL 307
|
330
....*....|....
gi 1717019280 313 GPALYGFIFYIFHV 326
Cdd:cd17502 308 GGTLGVAITDVFLV 321
|
|
| MFS_FBT |
cd17484 |
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ... |
6-251 |
6.73e-04 |
|
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 41.44 E-value: 6.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 6 QGVKGLLSFLSA--PLIGALSDVWG-----RKSFLLLTVFFTCAP---IPLMKIDAWWYFAVISVSGVFAVTFSVVF--A 73
Cdd:cd17484 36 QALTSIASLPWAikPLYGLLSDSVPifgyrRKPYLILAGALGALSwlaLALVSNSSLALALLLLLLASLGVAFSDVVidA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 74 YVADITQEHERSMAYGLVSATFAASlvtspAIGAYLSREYGNNLV--VVLATAIAVLDICFILVAVPESLpeKMRPASWG 151
Cdd:cd17484 116 LVVEASRGAPQSLAGDLQSLCWGSS-----AIGGIVGSYFSGYLLelLGPRTVFAVTSFFPLLLLIVAFF--VKEERVPP 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 152 APISWEQADPFASLKKVGQDSIVLLICITVFLSY-LPEAGqySSFFLYLRQVMEFSPESVaAFIAVLGILSIIAQTIVLS 230
Cdd:cd17484 189 HRTKENFDEQLKALWETVKQPSIWLPALFIFLYQaTPSSG--SAMFYFMTNELGFSPEFL-GRLRVIGSIASLLGVLLYN 265
|
250 260
....*....|....*....|.
gi 1717019280 231 LLMRSIGNKNTILLGLGFQIL 251
Cdd:cd17484 266 RFLKHVPFRKIFFWTTVLLVL 286
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
3-305 |
6.99e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 41.46 E-value: 6.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDV----WG-RKSFLLLTVFFTC---APIPLMKIDAWWYFAVISVSGVFAVTFSVVF-- 72
Cdd:cd17313 37 GFVWTLGPILGLFVQPLVGSLSDRcnsrIGrRRPFILVGAPLAAlglILIPNAADIGLALGDGPRTWALVLFVLGIVLld 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 73 -----------AYVADITQEHERSMAYGLVSATFAASLVTSPAIGAYLS------REYGNNLVVVLATAIAVLDICFI-- 133
Cdd:cd17313 117 famnvcqgpvrALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWdhnwfgFALGGNLKVPFYIGAIILLVCVLvt 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 134 LVAVPEslpEKMRPASWGAPISWEQADPFASLKKV--GQDSIVLLICITVFLSYLpeAGQYSSFF--LYLRQVMEFSP-- 207
Cdd:cd17313 197 LFFVKE---PPLSPEAGEHSENPSLGEVLKSLLKLlkIMPRSLLRLLLVIFFWWI--AFFPFELFftDYMGEEVYHGTsa 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 208 --------ESVAAFIavLGILSIIAQ--TIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSI 277
Cdd:cd17313 272 asshygagVRMGAWG--LLIFSLAFLifSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWA 349
|
330 340
....*....|....*....|....*....
gi 1717019280 278 TFPAVS-ALVSRTADADQQGvvQGMITGI 305
Cdd:cd17313 350 TININPyPLVSDYHSESGRG--QGTDTGL 376
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
3-327 |
9.16e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.00 E-value: 9.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKI--DAWWYFAVISVSGVFAVTFSVVFAYVADITQ 80
Cdd:cd17478 34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFapNYWLLLLLVALAGIGSAAFHPEGARLASQAA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 81 EHERSMAYGLVSA--TFAASLvtSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPASWGAPISWEQ 158
Cdd:cd17478 114 GGRRGLAMSIFSVggNLGFAL--GPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLK 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 159 ADPFAslkkvgqdsiVLLICITVFLSYLPEAGqYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGN 238
Cdd:cd17478 192 GVWRA----------LLLLLIIVFLRSWVLSS-LTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIG-TLIGGPLSDRFGR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 239 KNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTAdADQQGVVQGMITGIRGLCNGLGPALYG 318
Cdd:cd17478 260 RRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELL-PGNVGLASGLMMGLSFGLGGIGAPVLG 338
|
....*....
gi 1717019280 319 FIFYIFHVE 327
Cdd:cd17478 339 ALADAFGLE 347
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
10-128 |
9.56e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 41.05 E-value: 9.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 10 GLLSFLSAPLIGALSDVWGRKSFLLLT-VFFTCAPIPLMKI---DAWWYFAVISVSGVFAVTFSVVF-AYVADITQEHER 84
Cdd:cd17316 223 SLGALVGALIAGLLSDRIGRKKTLVIGlILSGILALPLFYLlsgSPTLLLLLLFILSFFVGGVWGALyAYLAELFPTEVR 302
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1717019280 85 SMAYGLVSAT-FAASLVTSPAIGAYLSREYGNNLVVVLATAIAVL 128
Cdd:cd17316 303 ATGVGLSYNLgRLGGGGAPPLIALLLASTGGTGVPALILALLAIV 347
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
173-321 |
1.19e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.02 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 173 IVLLICITVFLSYLPEAGqYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQtIVLSLLMRSIGNKNTILLGLGFQILQ 252
Cdd:COG2223 6 VLLLATLAFFLAFGVWYL-WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLR-IPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 253 LAWYGFGSEPWMMWAAGAVAAMSS-ITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIF 321
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI 153
|
|
| MFS_MFSD6L |
cd17479 |
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ... |
3-324 |
1.35e-03 |
|
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341032 [Multi-domain] Cd Length: 376 Bit Score: 40.76 E-value: 1.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKIDawwYFAVISVSGVFAVTFSVVFAYVAD----- 77
Cdd:cd17479 34 GIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYLLYHQ---IFLLVLLVIIIWELLSAPLEKVADdslye 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 78 ------ITQEHERSMAYGLVSATFAASLVT----------SPAIGAYLSREYGNNLVVVLATAIAVLdicfilvaVPESL 141
Cdd:cd17479 111 yldfvdATERYGKLKVWSALGAAFGPCGITllvdnldcflPPKISRILLHFYTYGGFMILTFLLSFF--------YPIPV 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 142 PEKMRPASWGapisweqadpFASLKKVGQDSIVLLICITVFLSYLPeAGQYSSFFLYLRQVMEFSPESVAAFIAVlGILS 221
Cdd:cd17479 183 PKKEEHSSKV----------VKGLRLLGGDGRAILYALTVFLVGFV-GSTVQNFLFWLMQDKGGSELHMGLSIAL-ALLS 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 222 IIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPA---------VSALVSRTADA 292
Cdd:cd17479 251 EILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGALWWavnsqveflASPGMERSLQL 330
|
330 340 350
....*....|....*....|....*....|..
gi 1717019280 293 dqqgVVQGMitgIRGLCNGLGPALYGFIFYIF 324
Cdd:cd17479 331 ----VLRAL---YYGIGFALGSFVSGFIYDRF 355
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
176-319 |
1.38e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 40.64 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 176 LICITVFLSYLPeagqyssFFLYLRQVMEFSPESVAAFIAVLGILSIIAQTIVLSLLMRsIGNKNTILLGLGFQILQLAW 255
Cdd:cd17330 9 ALGFGIVFPVLP-------FYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDR-YGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1717019280 256 YGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGF 319
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGF 144
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
3-320 |
1.52e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 40.32 E-value: 1.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKIDAWWYFAVIS--VSGVFAVTFSVVF-AYVADIT 79
Cdd:cd17393 37 GLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALAlfLFGAANGALDVAMnAQGVAVE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 80 QEHER---SMAYGLVSA-TFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEkmRPASWGAPIS 155
Cdd:cd17393 117 RAYGRpimSSLHAMWSLgGLAGALLGAAAIGAGVSPGVHLLAAAVLLLLAALVAIRALLPGTGEAAED--RPDGAGKPGF 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 156 weqadpfaslkkVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQVMEFSPESVAAFIAVLGILSIIAQtIVLSLLMRS 235
Cdd:cd17393 195 ------------LLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGR-LFGDRLVDR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 236 IGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAV-----AAMSSITFPAVSALVSRTADAdqqGVVQGMITGIRGLCn 310
Cdd:cd17393 262 FGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALmglglSVVVPLAFSAAGALPGLAAGI---AVARVATLGYLGFL- 337
|
330
....*....|
gi 1717019280 311 gLGPALYGFI 320
Cdd:cd17393 338 -VGPPLIGFL 346
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
19-289 |
3.00e-03 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 39.67 E-value: 3.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 19 LIGALSDVWGRKSFLLLTVF-FTCAPIPLMKIDAWWYFAVIS-VSGVFAVTFSVV-FAYVADITQEHERSMAYGLVSATF 95
Cdd:TIGR00710 59 LWGPLSDRYGRRPVLLLGLFiFALSSLGLALSNNIETLLVLRfVQAFGASAGSVIsQALVRDIYPGEELSRIYSILMPVL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 96 AASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPASwgaPISWEQ-ADPFASlKKVGQDSIV 174
Cdd:TIGR00710 139 ALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLPYEARIQI---STYFETfLLLLKS-KMFWGYALI 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 175 LLICITVFLSYLPEAGqyssfFLYLRQvMEFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTILLGLGFQILQLA 254
Cdd:TIGR00710 215 YGASFGGFFAFFSGAP-----FVYIDI-MGVSPSVFGLLFALNIIAMIFG-GFLNGRFIKKWGAKSLLRMGLILFAVSAV 287
|
250 260 270
....*....|....*....|....*....|....*...
gi 1717019280 255 WYGFGsepwMMWAAGAVAAMSSITF---PAVSALVSRT 289
Cdd:TIGR00710 288 LLEIT----AILGLGSWAMIIGPMMfvgIGNSMISSIA 321
|
|
| MFS_SLC46A1_PCFT |
cd17449 |
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ... |
11-320 |
3.35e-03 |
|
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341007 [Multi-domain] Cd Length: 425 Bit Score: 39.41 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 11 LLSFLSAPLIGALSDVWGRKSFLLLtvfftcaPIPLMKIDAWWYFAVIS----------------VSGVFAVTFSVVFAY 74
Cdd:cd17449 76 LVGLFSVTLLGPWSDSVGRRPVLIL-------PSLGLALQAAVYLLVMYlqlhvayfligrilsgLLGDFNGILAGCFAY 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 75 VADITQEHERSMAYGLVSATFAASLVTSPAIGAYLSRE--YGNNLVVVLATAIAVLDICFILVAVPESLPEKMRPASWGA 152
Cdd:cd17449 149 VADVSDRRSRTFRVAVLEACLGLAGMLASIIGGQWRKAqgYINPFWLVLALNLAAALYAAFCVGESVKEPKSARLFTTRH 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 153 PISWEQ----ADPFASLKKVGQDSIVLLICITVFLsylpeaGQYSSFFLY-LRQVMEFSPE-----SVAAFIAVLGILsi 222
Cdd:cd17449 229 HQSVVRlyvaPAPNGSRRKLALYSLALFVVVTVHF------GAKDLLVLYeLSSPLCWDSDligygSAAEHLTYLSSL-- 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 223 iaqtIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALVSRTADADQQGVVQGMI 302
Cdd:cd17449 301 ----LGLRLLQLCLEDTWVAEIGLISNISGLVVISVATTTPLMFTGYGLLFLSMATTPVIRAKLSKLVRETEQGALFASV 376
|
330 340
....*....|....*....|....*.
gi 1717019280 303 TGIRGLC--------NGLGPALYGFI 320
Cdd:cd17449 377 ACVEGLCslvatgifNSLYPATLHFM 402
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
19-259 |
4.86e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 38.82 E-value: 4.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 19 LIGALSDVWGRKSFLLLTV----FFTCApipLMKIDAWWYFAVI-SVSGV-FAVTFSVVFAYVADITQEHERSMAYGLVS 92
Cdd:cd17371 53 LGGILADRFGRVRVLVITIllfaVFTLL---CGFAQNYWQLLILrALAGLgFGGEWAAGAALMAEYVPARHRGKALGYVQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 93 ATFA-----ASLVTSPAIGaYLSREYGNNLVVVLAtAIAVLDICFILVAVPEslpekmrPASWGAPISWEQADPFASLKK 167
Cdd:cd17371 130 SGWAvgwllATLLAALLFP-LLPPEIAWRVLFLLG-ALPALLVLFIRRFVKE-------PPQWQAARAARRHFADRPSLR 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 168 VGQDSIVLLICI-TVFLSYLPEAGQYS-SFFL--YLRQVMEFSPESVAAFIAVLGILSIIAqTIVLSLLMRSIGNKNTIL 243
Cdd:cd17371 201 ELFSPPLLRTTLlASLLATGALGGYYGiTTWLpsYLTGERGLSFEGSAGYLVVTILGGFLG-YLAGGFLADRIGRRNNFA 279
|
250
....*....|....*.
gi 1717019280 244 LGLGFQILQLAWYGFG 259
Cdd:cd17371 280 LFALGSAISILLYFFL 295
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
3-324 |
4.90e-03 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 38.73 E-value: 4.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLM-----KIDAWWYFAVIS---VSGVFAVTFSVVFAY 74
Cdd:cd17326 39 GWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVSILIAIVGNILyalaeYFPSNRKYVMLVarfLIGVGAGNVAVLRAY 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 75 VADITQEHERSMAYGLVSATFAASLVTSPAIGAYLS------REYGNNLVVVLATAIAVLDICFILVAVpeslpekmrpa 148
Cdd:cd17326 119 VAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTpigypgYVIGIKLRFNMYTAPAWLMAILGIINI----------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 149 swgapisweqadpfaslkkvgqdsIVLLICITVFLSYLPEAGQYSSFFLY------LRQVM-----EFSPESVAAFIAVL 217
Cdd:cd17326 188 ------------------------ILILFFFKEVVCIFLFFVVLFIFANLetigtpLTMDMygwtrEEAVLYNGIILAVS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 218 GILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYgfgsepwMMWAAGAVAAMsSITFPAVS----ALVSRTADAD 293
Cdd:cd17326 244 GVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFVVT-------LPWGITGVILF-GLGYPIGNvmlyTLYSKILGPK 315
|
330 340 350
....*....|....*....|....*....|.
gi 1717019280 294 QQGVVQGMITGIRGLCNGLGPALYGFIFYIF 324
Cdd:cd17326 316 PQGTMQGVLTASGSLARTLGPIFVTAIYTHF 346
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
18-324 |
8.70e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 37.94 E-value: 8.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 18 PLIGALSDVWGRKS-FLLLTVFFT-----CAPIPlmkiDAWWYFAVISVSGVF-AVTFSVVFAYVADITQEHERSMAYGL 90
Cdd:cd17503 49 PLSGWLADRFGTRRlFLTALALFTlgsllCGLAP----NLASLIIFRILQGFGgGVLIPLAQTILLRIYPPEKRGAAMGL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 91 VSATFAASLVTSPAIGAYLSREYGNNLVVVLATAIAVldICFILVavpeslpekmrpaswgapisweqadPFASLKkVGQ 170
Cdd:cd17503 125 VGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGI--LALLLA-------------------------PLLDLR-LFK 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 171 DSIVLLICITVFLSYLpeaGQYSSFF---LYLRQVMEFSPESVAAFIAVLGILSIIAQTIVlSLLMRSIGNKNTILLGL- 246
Cdd:cd17503 177 DRNFTLGLLLSFLLGL---GLFGAMFllpLYLQNVLGYSAFESGLVLAPGGLASAILSPLV-GRLLDKFGPRLLLLAGLl 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 247 --GFQILQLAWYGFGSEPWMMWAAGAVAAMS-SITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYI 323
Cdd:cd17503 253 llALGTLLLAFLTPDTSLWLIILPLFIRGLGmGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTN 332
|
.
gi 1717019280 324 F 324
Cdd:cd17503 333 R 333
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
3-134 |
8.78e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.18 E-value: 8.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1717019280 3 GLIQGVKGLLSFLSAPLIGALSD-VWGRKSFLLLTVF---FTCAPIPLMKIDAWWYFAVISVSGVFAVTFSVVFAYVADI 78
Cdd:cd06174 242 GLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLlmaLGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAEL 321
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1717019280 79 TQEHERSMAYGLVSAT-FAASLVTSPAIGAYLSREYGNNLVVVLATAIAVLDICFIL 134
Cdd:cd06174 322 FPPEIRGTAFGLLNTFgFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| |
