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Conserved domains on  [gi|171460948|ref|NP_904358|]
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TSC22 domain family protein 1 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZIP_TSC22D1 cd21938
leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 ...
 983-1061 9.36e-35

leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 (TSC22D1) is also called cerebral protein 2, regulatory protein TSC-22, TGFB-stimulated clone 22, or transforming growth factor beta-1-induced transcript 4 protein (TGFB1I4). It is a transcriptional repressor that was reported to be present in both the cytoplasmic and the nuclear fraction. It is activated by transcription growth factor-beta1 and other growth factors of osteoblastic cells. TSC22D1 acts on the C-type natriuretic peptide (CNP) promoter. It enhances c-Myc-mediated activation of the telomerase reverse transcriptase (TERT) promoter. This model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D1. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


:

Pssm-ID: 409278  Cd Length: 79  Bit Score: 127.18  E-value: 9.36e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 171460948  983 KIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPATTQPQGTTQPP 1061
Cdd:cd21938     1 KIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPSSSQPPGTTPQP 79
rne super family cl35953
ribonuclease E; Reviewed
 685-899 4.69e-05

ribonuclease E; Reviewed


The actual alignment was detected with superfamily member PRK10811:

Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 47.73  E-value: 4.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  685 PVAQPQGIQL--PVQPTAVPAQPAGASVQPVGQAPAAVSAvptgsqianigqqaniPTAVQQPSTQVPPSVIQQGAPPSS 762
Cdd:PRK10811  846 PVVRPQDVQVeeQREAEEVQVQPVVAEVPVAAAVEPVVSA----------------PVVEAVAEVVEEPVVVAEPQPEEV 909

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  763 QVVPPAQTGIIhqgvqtSAPSLPQQLVIASQSslltvppqpqgvEPVAQGIVSQQLPAVSSLPSASSISVTSQVsstgps 842
Cdd:PRK10811  910 VVVETTHPEVI------AAPVTEQPQVITESD------------VAVAQEVAEHAEPVVEPQDETADIEEAAET------ 965

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 171460948  843 gmpsAPTNLVPPQNIAQTPATQNGNLVQSVSQPPLIATNTNLPLAQQIPLSSTQFSA 899
Cdd:PRK10811  966 ----AEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEVAPAQVPEATVEHNHATA 1018
 
Name Accession Description Interval E-value
ZIP_TSC22D1 cd21938
leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 ...
 983-1061 9.36e-35

leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 (TSC22D1) is also called cerebral protein 2, regulatory protein TSC-22, TGFB-stimulated clone 22, or transforming growth factor beta-1-induced transcript 4 protein (TGFB1I4). It is a transcriptional repressor that was reported to be present in both the cytoplasmic and the nuclear fraction. It is activated by transcription growth factor-beta1 and other growth factors of osteoblastic cells. TSC22D1 acts on the C-type natriuretic peptide (CNP) promoter. It enhances c-Myc-mediated activation of the telomerase reverse transcriptase (TERT) promoter. This model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D1. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409278  Cd Length: 79  Bit Score: 127.18  E-value: 9.36e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 171460948  983 KIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPATTQPQGTTQPP 1061
Cdd:cd21938     1 KIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPSSSQPPGTTPQP 79
TSC22 pfam01166
TSC-22/dip/bun family;
988-1034 6.27e-27

TSC-22/dip/bun family;


Pssm-ID: 460093  Cd Length: 57  Bit Score: 103.93  E-value: 6.27e-27
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 171460948   988 MDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPE 1034
Cdd:pfam01166    1 MDLVKSHLMYAVREEVEVLKEQIKELEERNSQLEEENSILRANASPE 47
rne PRK10811
ribonuclease E; Reviewed
 685-899 4.69e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 47.73  E-value: 4.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  685 PVAQPQGIQL--PVQPTAVPAQPAGASVQPVGQAPAAVSAvptgsqianigqqaniPTAVQQPSTQVPPSVIQQGAPPSS 762
Cdd:PRK10811  846 PVVRPQDVQVeeQREAEEVQVQPVVAEVPVAAAVEPVVSA----------------PVVEAVAEVVEEPVVVAEPQPEEV 909

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  763 QVVPPAQTGIIhqgvqtSAPSLPQQLVIASQSslltvppqpqgvEPVAQGIVSQQLPAVSSLPSASSISVTSQVsstgps 842
Cdd:PRK10811  910 VVVETTHPEVI------AAPVTEQPQVITESD------------VAVAQEVAEHAEPVVEPQDETADIEEAAET------ 965

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 171460948  843 gmpsAPTNLVPPQNIAQTPATQNGNLVQSVSQPPLIATNTNLPLAQQIPLSSTQFSA 899
Cdd:PRK10811  966 ----AEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEVAPAQVPEATVEHNHATA 1018
PRK13169 PRK13169
DNA replication initiation control protein YabA;
1001-1030 1.84e-03

DNA replication initiation control protein YabA;


Pssm-ID: 183876  Cd Length: 110  Bit Score: 39.07  E-value: 1.84e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 171460948 1001 EEVEVLKEQIKELIEKNSQLEQENNLLKTL 1030
Cdd:PRK13169   22 KELGALKKQLAELLEENTALRLENDKLRER 51
 
Name Accession Description Interval E-value
ZIP_TSC22D1 cd21938
leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 ...
 983-1061 9.36e-35

leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 (TSC22D1) is also called cerebral protein 2, regulatory protein TSC-22, TGFB-stimulated clone 22, or transforming growth factor beta-1-induced transcript 4 protein (TGFB1I4). It is a transcriptional repressor that was reported to be present in both the cytoplasmic and the nuclear fraction. It is activated by transcription growth factor-beta1 and other growth factors of osteoblastic cells. TSC22D1 acts on the C-type natriuretic peptide (CNP) promoter. It enhances c-Myc-mediated activation of the telomerase reverse transcriptase (TERT) promoter. This model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D1. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409278  Cd Length: 79  Bit Score: 127.18  E-value: 9.36e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 171460948  983 KIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPATTQPQGTTQPP 1061
Cdd:cd21938     1 KIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPSSSQPPGTTPQP 79
ZIP_TSC22D4 cd21941
leucine zipper domain found in TSC22 domain family protein 4; TSC22 domain family protein 4 ...
 978-1050 2.59e-28

leucine zipper domain found in TSC22 domain family protein 4; TSC22 domain family protein 4 (TSC22D4), also called TSC22-related-inducible leucine zipper protein 2 (TILZ2), or Tsc-22-like protein THG-1, is a transcriptional repressor that acts as a molecular determinant of insulin signalling and glucose handling. It also functions in hepatic lipid handling by regulating hepatic very-low-density-lipoprotein (VLDL) release and lipogenic gene expression. This model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D4. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409281  Cd Length: 74  Bit Score: 108.87  E-value: 2.59e-28
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 171460948  978 VAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPA 1050
Cdd:cd21941     1 VAIDNKIEQAMDLVKSHLLFAVREEVEVLKEQIKELSERNAALEQENSLLRSLATPQQLSRLQSRQPTSRKPA 73
ZIP_TSC22D cd21936
leucine zipper domain found in the TSC22 domain family of leucine zipper transcription factors; ...
 987-1034 1.17e-27

leucine zipper domain found in the TSC22 domain family of leucine zipper transcription factors; The TGF-beta-stimulated clone-22 domain (TSC22D) family includes TSC22D1-4 and similar proteins. They have diverse physiological functions, including cell growth, development, homeostasis, and immune regulation. All family members contain a conserved leucine zipper (ZIP) domain located at the C-terminus. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. In the bZIP family of transcription factors, the leucine zipper acts as a dimerization domain and the upstream basic region as a DNA-binding domain. However, DNA-binding capability of TSC22D family proteins is not obvious, due to the lack of the basic region found in the original bZIP DNA-binding domains. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409276  Cd Length: 49  Bit Score: 106.11  E-value: 1.17e-27
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 171460948  987 AMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPE 1034
Cdd:cd21936     1 AMDLVKSHLMFAVREEVDVLKEQIAELEERISQLERENSLLRSNAPPE 48
ZIP_TSC22D3 cd21940
leucine zipper domain found in TSC22 domain family protein 3; TSC22 domain family protein 3 ...
 987-1070 1.49e-27

leucine zipper domain found in TSC22 domain family protein 3; TSC22 domain family protein 3 (TSC22D3) is also called DSIP-immunoreactive peptide, protein DIP, delta sleep-inducing peptide immunoreactor, glucocorticoid-induced leucine zipper protein (GILZ), TSC-22-like protein, or TSC-22-related protein (TSC-22R). It protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, it plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, it inhibits anti-CD3-induced NFKB1 nuclear translocation. TSC22D3 contains a leucine zipper motif, a Pro/Glu rich domain, and three potential phosphorylation sites. This model corresponds to the leucine zipper (ZIP) domain. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409280  Cd Length: 81  Bit Score: 106.96  E-value: 1.49e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  987 AMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLqtgsPPATTQPQgtTQPPAQPAS 1066
Cdd:cd21940     1 AMDLVKNHLMYAVREEVEVLKEQIKELVEKNSQLERENSLLKTLASPEQLEKFQSRL----PSEETAPE--TPLDAQPAE 74


                  ....
gi 171460948 1067 QGSG 1070
Cdd:cd21940    75 HSGG 78
TSC22 pfam01166
TSC-22/dip/bun family;
988-1034 6.27e-27

TSC-22/dip/bun family;


Pssm-ID: 460093  Cd Length: 57  Bit Score: 103.93  E-value: 6.27e-27
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 171460948   988 MDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPE 1034
Cdd:pfam01166    1 MDLVKSHLMYAVREEVEVLKEQIKELEERNSQLEEENSILRANASPE 47
ZIP_TSC22D2 cd21939
leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 ...
 987-1034 6.82e-22

leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 (TSC22D2), also called transforming growth factor beta-stimulated clone 22 domain family member 2, or TSC22-related-inducible leucine zipper protein 4 (TILZ4), may participate in the regulation of cell growth. It interacts with pyruvate kinase isoform M2 (PKM2) and WD repeat domain 77 (WDR77). The model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D2. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409279  Cd Length: 63  Bit Score: 90.02  E-value: 6.82e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 171460948  987 AMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPE 1034
Cdd:cd21939     1 AMDLVKSHLMYAVREEVEVLKEQIKELIERNSLLERENALLKSLSNND 48
ZIP_TSC22D-like cd21927
leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding ...
 988-1034 3.48e-20

leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins; The family includes TGF-beta-stimulated clone-22 domain (TSC22D) leucine zipper transcription factors, TSC22D1-4, as well as c-Myc-binding protein (MycBP). TSC22D proteins have diverse physiological functions, including cell growth, development, homeostasis, and immune regulation. MycBP, also called associate of Myc 1 (AMY-1), is a novel c-Myc binding protein that may control the transcriptional activity of Myc. It stimulates the activation of E box-dependent transcription by Myc. Members of this family contain a conserved leucine zipper (ZIP) domain. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. In the bZIP family of transcription factors, the leucine zipper acts as a dimerization domain and the upstream basic region as a DNA-binding domain. However, DNA-binding capability of TSC22D family proteins is not obvious, due to the lack of the basic region found in the original bZIP DNA-binding domains. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409275  Cd Length: 51  Bit Score: 84.87  E-value: 3.48e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 171460948  988 MDLVKSHLMYAVREE--VEVLKEQIKELIEKNSQLEQENNLLKTLASPE 1034
Cdd:cd21927     2 LDFLKHHLGAATPENpeIELLRLELAEMKEKYEAIVEENKKLKAKLAQY 50
ZIP_MycBP-like cd21937
leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called ...
 987-1029 1.67e-05

leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called associate of Myc 1 (AMY-1), is a novel c-Myc binding protein that may control the transcriptional activity of Myc. It stimulates the activation of E box-dependent transcription by Myc. This model corresponds to the conserved region that shows high sequence similarity with the leucine zipper (ZIP) domain located at the C-terminus of TGF-beta-stimulated clone-22 domain (TSC22D) family transcription factors. The first helix of ZIP is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409277 [Multi-domain]  Cd Length: 53  Bit Score: 43.31  E-value: 1.67e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 171460948  987 AMDLVKSHL--MYAVREEVEVLKEQIKELIEKNSQLEQENNLLKT 1029
Cdd:cd21937     3 ALDFIKQHLgaPGPEDADVEALRLENEELKQKNEELEEENKELKA 47
rne PRK10811
ribonuclease E; Reviewed
 685-899 4.69e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 47.73  E-value: 4.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  685 PVAQPQGIQL--PVQPTAVPAQPAGASVQPVGQAPAAVSAvptgsqianigqqaniPTAVQQPSTQVPPSVIQQGAPPSS 762
Cdd:PRK10811  846 PVVRPQDVQVeeQREAEEVQVQPVVAEVPVAAAVEPVVSA----------------PVVEAVAEVVEEPVVVAEPQPEEV 909

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  763 QVVPPAQTGIIhqgvqtSAPSLPQQLVIASQSslltvppqpqgvEPVAQGIVSQQLPAVSSLPSASSISVTSQVsstgps 842
Cdd:PRK10811  910 VVVETTHPEVI------AAPVTEQPQVITESD------------VAVAQEVAEHAEPVVEPQDETADIEEAAET------ 965

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 171460948  843 gmpsAPTNLVPPQNIAQTPATQNGNLVQSVSQPPLIATNTNLPLAQQIPLSSTQFSA 899
Cdd:PRK10811  966 ----AEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEVAPAQVPEATVEHNHATA 1018
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 661-809 6.62e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.39  E-value: 6.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  661 PILQTAMSSGQPSSAGVGAGTTVIPVAQPQGIQLPVQPTAvPAQPAGASVQPVGQAPaavsavptgsQIANIGQQANIPT 740
Cdd:PRK10263  747 PIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVA-PQPQYQQPQQPVAPQP----------QYQQPQQPVAPQP 815

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 171460948  741 AVQQPSTQVPPSviQQGAPPSSQVVPPAQTGIIHQGVQTSAPSLPQQLVIASQSSLLTVPPQPQGVEPV 809
Cdd:PRK10263  816 QYQQPQQPVAPQ--PQYQQPQQPVAPQPQDTLLHPLLMRNGDSRPLHKPTTPLPSLDLLTPPPSEVEPV 882
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
682-811 1.01e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 46.31  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  682 TVIPVAQPQGIQLPVQPTAVPAQPAGASV-QPVGQAPAAVSAVPTGSQIAN-IGQQANIPTAVQQPSTQVPPSVIQQGAP 759
Cdd:PRK14971  355 TLIQLAQLTQKGDDASGGRGPKQHIKPVFtQPAAAPQPSAAAAASPSPSQSsAAAQPSAPQSATQPAGTPPTVSVDPPAA 434

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 171460948  760 pssQVVPPAQTGIIHQGVQTSAPSLPQQLVIASQSSLLTVPP------QPQGVEPVAQ 811
Cdd:PRK14971  435 ---VPVNPPSTAPQAVRPAQFKEEKKIPVSKVSSLGPSTLRPiqekaeQATGNIKEAP 489
PHA03247 PHA03247
large tegument protein UL36; Provisional
 564-850 1.06e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  564 PVPLQATMSAATGIQPSPVNVVGVTSALGQQPSISSLAQPQLPYSQAAPPVQTPLPGAPPPQQLQYGQQQPMVSTQMAPG 643
Cdd:PHA03247 2712 PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASL 2791

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  644 HVkSVTQNPASEYVQQQPILQTAMSSGQPSSAGVGAGTTVIPVAQPQGIQLPVQPTAvPAQPAGASVQPVG--------Q 715
Cdd:PHA03247 2792 SE-SRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPP-PSLPLGGSVAPGGdvrrrppsR 2869

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  716 APAAVSAVPTGSQIANIGQqanipTAVQQPSTQVPPSVIQQGAPPSSQVVPPAQTGIIHQGVQTSAPSLPQQlviASQSS 795
Cdd:PHA03247 2870 SPAAKPAAPARPPVRRLAR-----PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPP---PRPQP 2941

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 171460948  796 LLTVPPQPQGVEPVAQGIVSQQLPAVSSLPSASSISVTSQVSSTGPSGMPSAPTN 850
Cdd:PHA03247 2942 PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPL 2996
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
671-911 1.11e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.41  E-value: 1.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  671 QPSSAGVGAGTTVIPVAQPQ--GIQLPVQPTAVPAQPAGASVQPVGQAPAAVSAVPTGSQIANIGQ-QANIPTAVQQPST 747
Cdd:PRK12323  373 GPATAAAAPVAQPAPAAAAPaaAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQaSARGPGGAPAPAP 452

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  748 QVPPSVIQQGAPPSSQVVPPAQTgiihqgvqTSAPSLPQQLVIASQSSLLTVPPQPQGVEPVAQGIVSQQLPAVSSLPSA 827
Cdd:PRK12323  453 APAAAPAAAARPAAAGPRPVAAA--------AAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAE 524

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  828 SSI-SVTSQVSSTGPSGMPSAPTNLVPPQNIAQTPATQNGNLVQSVSQPPLIATNTNLPLAQQIPLsstqfsaQSLAQAI 906
Cdd:PRK12323  525 SIPdPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARLPV-------RGLAQQL 597


                  ....*
gi 171460948  907 GSQIE 911
Cdd:PRK12323  598 ARQSE 602
PHA03378 PHA03378
EBNA-3B; Provisional
 561-818 9.22e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.52  E-value: 9.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  561 GLQPVPLQATMSAATGIQPSPVNVVGVTSALGQQPSisslAQPQLPYSQAAPPVQTPLPGAPPPQQLQYGQQQPMVSTQM 640
Cdd:PHA03378  568 GLGPLQIQPLTSPTTSQLASSAPSYAQTPWPVPHPS----QTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPITF 643

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  641 APGHVKSVTQNPASEYVQQQPI-LQTAMSSGQPSSAGVGA--------GTTVIPVAQPQGIQLPVQPTAVPAQPAGASVQ 711
Cdd:PHA03378  644 NVLVFPTPHQPPQVEITPYKPTwTQIGHIPYQPSPTGANTmlpiqwapGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGR 723

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  712 PVGQAPAAVSAVPTGSQIANIGQQANIPTAVQQPSTQVPPSVIQQGAPPSSQVVPPAQTGIIHQGVQTSAPSlPQQLVIA 791
Cdd:PHA03378  724 ARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPT-PQPPPQA 802

                         250       260
                  ....*....|....*....|....*..
gi 171460948  792 SQSSLLTVPPQPQGVEPVAQGIVSQQL 818
Cdd:PHA03378  803 GPTSMQLMPRAAPGQQGPTKQILRQLL 829
PHA03247 PHA03247
large tegument protein UL36; Provisional
 596-903 1.29e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  596 SISSLAQPQLPYSQAAPPVQTPLPGAPPPQQLQYGQQQPMVSTQM-APGHVKSVTQNPASEYVQQQPILQTAMSSGQPSS 674
Cdd:PHA03247 2694 SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAApAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPA 2773

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  675 AGVGA---GTTVIPVAQ----PQGIQLPVQPTAVPAQ-PAGASVQPVGQAPAAVSAVPTGSQianigqqaniPTAVQQPS 746
Cdd:PHA03247 2774 APAAGpprRLTRPAVASlsesRESLPSPWDPADPPAAvLAPAAALPPAASPAGPLPPPTSAQ----------PTAPPPPP 2843

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  747 TQVPPSVIQQGA----------PPSSQVVPPAQTGIIHQGVQTSAPSLPQQLVIASQSSL-LTVPPQPQGVEPVAQGIVS 815
Cdd:PHA03247 2844 GPPPPSLPLGGSvapggdvrrrPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDqPERPPQPQAPPPPQPQPQP 2923

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  816 QQLPAVSSLPSASSISVTSQVSSTGPSGMPSAPTNLVPPQNIAQTPATQNGNLVQ-SVSQPPLIATNTNLPLAQQIPLSS 894
Cdd:PHA03247 2924 PPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRvPQPAPSREAPASSTPPLTGHSLSR 3003


                  ....*....
gi 171460948  895 TQFSAQSLA 903
Cdd:PHA03247 3004 VSSWASSLA 3012
PRK13169 PRK13169
DNA replication initiation control protein YabA;
1001-1030 1.84e-03

DNA replication initiation control protein YabA;


Pssm-ID: 183876  Cd Length: 110  Bit Score: 39.07  E-value: 1.84e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 171460948 1001 EEVEVLKEQIKELIEKNSQLEQENNLLKTL 1030
Cdd:PRK13169   22 KELGALKKQLAELLEENTALRLENDKLRER 51
PHA03247 PHA03247
large tegument protein UL36; Provisional
 685-926 2.23e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  685 PVAQPQGIQLPVQPTAVPAQPAGASVQPVGQAPAAVSAVPTGSQianigqQANIPTAVQQPSTQVPPSVIQQGAPPSSQV 764
Cdd:PHA03247 2712 PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPA------RPARPPTTAGPPAPAPPAAPAAGPPRRLTR 2785

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  765 VPPAQtgiihqgVQTSAPSLPQqlviasqsslltvPPQPQGVEPVAQGIVSQQLPAVSSLPSASSISVTSQVSSTGPSGM 844
Cdd:PHA03247 2786 PAVAS-------LSESRESLPS-------------PWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP 2845

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  845 PSAPTNL-------------VPPQNIAQTPATQNGNLVQSVSQPPLIATNTNLPLAQQIPLSSTQFSAQSLAQAIGSQIE 911
Cdd:PHA03247 2846 PPPSLPLggsvapggdvrrrPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP 2925

                         250
                  ....*....|....*
gi 171460948  912 DARRAAEPSLVGLPQ 926
Cdd:PHA03247 2926 PPQPQPPPPPPPRPQ 2940
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 582-787 3.12e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 3.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  582 VNVVGVTSALGQQPSISSLAQPQLPYSQAAPPVQTPLPGAPPPQQLQYGQQQPmvstqmAPGHVKSVTQNPASEYVQQQP 661
Cdd:PRK07764  584 VEAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAP------AEASAAPAPGVAAPEHHPKHV 657

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  662 ILQTAMSSGQPSSAGVGAGTTVIPVAQPQgiqlPVQPTAVPAQPAGASVQPVGQAPAAVSAVPTGSQIANIGQQANIPTA 741
Cdd:PRK07764  658 AVPDASDGGDGWPAKAGGAAPAAPPPAPA----PAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSP 733

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 171460948  742 VQQPSTQVPPSVIQQGAPPSSQVVPPAQTGIIHQGVQTSAPSLPQQ 787
Cdd:PRK07764  734 AADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPP 779
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 653-784 3.95e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  653 ASEYVQQQPILQTAmSSGQPSSAGVGAGTTVIPVAQPQGIQLPV-QPTAVPAQPAGASVQPVGQAPAAVSAVPTGSQIAN 731
Cdd:PRK07764  390 GAGAPAAAAPSAAA-AAPAAAPAPAAAAPAAAAAPAPAAAPQPApAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAP 468

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 171460948  732 IGQQANIPTAVQQPSTQVPPSviQQGAPPSSQVVPPAQTGIIHQGVQTSAPSL 784
Cdd:PRK07764  469 APAAAPEPTAAPAPAPPAAPA--PAAAPAAPAAPAAPAGADDAATLRERWPEI 519
ZapB pfam06005
Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is ...
 983-1028 4.73e-03

Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is required for proper Z-ring formation.


Pssm-ID: 428718 [Multi-domain]  Cd Length: 71  Bit Score: 36.86  E-value: 4.73e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 171460948   983 KIEQAMDLVkSHLmyavREEVEVLKEQIKELIEKNSQLEQENNLLK 1028
Cdd:pfam06005   12 KIQAAVDTI-ALL----QMENEELKEENEELKEEANELEEENQQLK 52
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
644-772 4.94e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.91  E-value: 4.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 171460948  644 HVKSVTQNPASeyvQQQPILQTAMSSGQPSSAGVGAGTTVIPVAQPQGIQLPV---QPTAVPAQPAGASVQPVGQAPAAV 720
Cdd:PRK14971  378 HIKPVFTQPAA---APQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVsvdPPAAVPVNPPSTAPQAVRPAQFKE 454

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 171460948  721 SAVPTGSQIANIGqqaniptavqqPSTQVPpsvIQQGAPPSSQVVPPAQTGI 772
Cdd:PRK14971  455 EKKIPVSKVSSLG-----------PSTLRP---IQEKAEQATGNIKEAPTGT 492
DUF6262 pfam19776
Family of unknown function (DUF6262); This family of proteins, functionally uncharacterized, ...
 979-1027 6.56e-03

Family of unknown function (DUF6262); This family of proteins, functionally uncharacterized, is found in bacteria. Proteins in this family are typically between 124 and 143 amino acids in length. Some members included in this family are hypothetical transposases, associated with transposon Tn554. There is a conserved sequence GV/LSR/K and a highly conserved tyrosine residue.


Pssm-ID: 466180 [Multi-domain]  Cd Length: 110  Bit Score: 37.60  E-value: 6.56e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 171460948   979 AIDNKIEQAMDLVKSH---LMYAVREEVEVLKEQIKELIEKNSQLEQENNLL 1027
Cdd:pfam19776   59 ELDEAIEQQGGMVNPKreiLDMALEKRIELLKKEIKELKRENEELKKENEKL 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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