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Conserved domains on  [gi|1713652087|gb|TVV44859|]
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lytic transglycosylase [Thalassolituus sp. C2-1]

Protein Classification

LT_MltC_MltE domain-containing protein( domain architecture ID 13013998)

LT_MltC_MltE domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 202-363 1.75e-98

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


:

Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 289.07  E-value: 1.75e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 202 PLVQTASAKWQVSPALVMAIMQTESAFNPMAQSHVPAFGLMQIVPGSAGRDATKKVYGKERLLTGAELFKPQTNIELGCA 281
Cdd:cd16893     1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGLPSKSYLFDPENNIDIGTA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 282 YLHILDRQYLSAVTDPQSRLYCVIAAYNTGAGNVARAFSGNtsVKEAARRINAMSPKQVYAHLRTRLKYEETRNYVQKVT 361
Cdd:cd16893    81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSD--RKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVL 158


                  ..
gi 1713652087 362 AA 363
Cdd:cd16893   159 KA 160
 
Name Accession Description Interval E-value
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 202-363 1.75e-98

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 289.07  E-value: 1.75e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 202 PLVQTASAKWQVSPALVMAIMQTESAFNPMAQSHVPAFGLMQIVPGSAGRDATKKVYGKERLLTGAELFKPQTNIELGCA 281
Cdd:cd16893     1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGLPSKSYLFDPENNIDIGTA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 282 YLHILDRQYLSAVTDPQSRLYCVIAAYNTGAGNVARAFSGNtsVKEAARRINAMSPKQVYAHLRTRLKYEETRNYVQKVT 361
Cdd:cd16893    81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSD--RKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVL 158


                  ..
gi 1713652087 362 AA 363
Cdd:cd16893   159 KA 160
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
173-367 2.52e-59

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 195.66  E-value: 2.52e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 173 QQNTSKGKVIT-ITIPLQAGALPARAQNFLPLVQTASAKWQVSPALVMAIMQTESAFNPMAQSHVPAFGLMQIVPGSAGR 251
Cdd:PRK11671  164 QSRSNGLRIIYsVTINMVPNHLDKRAHKYLPMVRKASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAGK 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 252 DATkKVYGKERLLTGAELFKPQTNIELGCAYLHILDRQYLSAVTDPQSRLYCVIAAYNTGAGNVARAFSGNTsvKEAARR 331
Cdd:PRK11671  244 DVF-RMKGKSGQPSRSYLFDPANNIDTGTAYLAILQNVYLGGITNPTSRRYAVITAYNGGAGSVLRVFSNDK--IQAANI 320

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1713652087 332 INAMSPKQVYAHLRTRLKYEETRNYVQKVTAALAQY 367
Cdd:PRK11671  321 INTMSPGDVYQTLTTRHPSAESRRYLYKVNTAQKSY 356
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 189-368 1.22e-38

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 138.20  E-value: 1.22e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 189 QAGALPARAQNFLPLVQTASAKWQVSPALVMAIMQTESAFNPMAQSHVPAFGLMQIVPGSAGRdatkkvYGKE--RLLTG 266
Cdd:COG0741    92 LAALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATARR------LGLKlgLGPSP 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 267 AELFKPQTNIELGCAYLHILDRQYLsavtdpqSRLYCVIAAYNTGAGNVARAFSGNTSVKeaarrinamspkqvyahlRT 346
Cdd:COG0741   166 DDLFDPETNIRAGAAYLRELLDRFD-------GDLVLALAAYNAGPGRVRRWLRRNGDRD------------------GE 220

                         170       180
                  ....*....|....*....|..
gi 1713652087 347 RLKYEETRNYVQKVTAALAQYQ 368
Cdd:COG0741   221 IIPYAETRNYVKKVLANYAIYR 242
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 207-322 1.41e-28

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 107.39  E-value: 1.41e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 207 ASAKWQVSPALVMAIMQTESAFNPMAQSHVPAFGLMQIVPGSAGRDAtKKVYGKERlltgaELFKPQTNIELGCAYLHIL 286
Cdd:pfam01464   4 AAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLG-LRVNPGVD-----DLFDPEKNIKAGTKYLKEL 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1713652087 287 DRQYLsavtdpqSRLYCVIAAYNTGAGNVARAFSGN 322
Cdd:pfam01464  78 YKQYG-------GDLWLALAAYNAGPGRVRKWIKNA 106
 
Name Accession Description Interval E-value
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 202-363 1.75e-98

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 289.07  E-value: 1.75e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 202 PLVQTASAKWQVSPALVMAIMQTESAFNPMAQSHVPAFGLMQIVPGSAGRDATKKVYGKERLLTGAELFKPQTNIELGCA 281
Cdd:cd16893     1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGLPSKSYLFDPENNIDIGTA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 282 YLHILDRQYLSAVTDPQSRLYCVIAAYNTGAGNVARAFSGNtsVKEAARRINAMSPKQVYAHLRTRLKYEETRNYVQKVT 361
Cdd:cd16893    81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSD--RKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVL 158


                  ..
gi 1713652087 362 AA 363
Cdd:cd16893   159 KA 160
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
173-367 2.52e-59

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 195.66  E-value: 2.52e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 173 QQNTSKGKVIT-ITIPLQAGALPARAQNFLPLVQTASAKWQVSPALVMAIMQTESAFNPMAQSHVPAFGLMQIVPGSAGR 251
Cdd:PRK11671  164 QSRSNGLRIIYsVTINMVPNHLDKRAHKYLPMVRKASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAGK 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 252 DATkKVYGKERLLTGAELFKPQTNIELGCAYLHILDRQYLSAVTDPQSRLYCVIAAYNTGAGNVARAFSGNTsvKEAARR 331
Cdd:PRK11671  244 DVF-RMKGKSGQPSRSYLFDPANNIDTGTAYLAILQNVYLGGITNPTSRRYAVITAYNGGAGSVLRVFSNDK--IQAANI 320

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1713652087 332 INAMSPKQVYAHLRTRLKYEETRNYVQKVTAALAQY 367
Cdd:PRK11671  321 INTMSPGDVYQTLTTRHPSAESRRYLYKVNTAQKSY 356
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 189-368 1.22e-38

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 138.20  E-value: 1.22e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 189 QAGALPARAQNFLPLVQTASAKWQVSPALVMAIMQTESAFNPMAQSHVPAFGLMQIVPGSAGRdatkkvYGKE--RLLTG 266
Cdd:COG0741    92 LAALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATARR------LGLKlgLGPSP 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 267 AELFKPQTNIELGCAYLHILDRQYLsavtdpqSRLYCVIAAYNTGAGNVARAFSGNTSVKeaarrinamspkqvyahlRT 346
Cdd:COG0741   166 DDLFDPETNIRAGAAYLRELLDRFD-------GDLVLALAAYNAGPGRVRRWLRRNGDRD------------------GE 220

                         170       180
                  ....*....|....*....|..
gi 1713652087 347 RLKYEETRNYVQKVTAALAQYQ 368
Cdd:COG0741   221 IIPYAETRNYVKKVLANYAIYR 242
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 200-368 5.64e-31

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 114.88  E-value: 5.64e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 200 FLPLVQTASAKWQVSPALVMAIMQTESAFNPMAQSHVPAFGLMQIVPGSAGRDATKKvygKERLLTGAELFKPQTNIELG 279
Cdd:cd13401     6 YRDLVERAAKKNGLDPALVYAIIRQESAFDPDAVSPAGALGLMQLMPATAKDVAKKL---GLPYYSPRDLFDPEYNIRLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 280 CAYLHILDRQYlsavtdPQSRLYcVIAAYNTGAGNVARaFSGNTSVKEAARRINAMSpkqvyahlrtrlkYEETRNYVQK 359
Cdd:cd13401    83 SAYLAELLDRF------DGNPVL-ALAAYNAGPGRVRR-WLKRRGDLDPDLWIETIP-------------FSETRNYVKR 141


                  ....*....
gi 1713652087 360 VTAALAQYQ 368
Cdd:cd13401   142 VLENYVVYR 150
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 203-363 1.35e-30

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 113.76  E-value: 1.35e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 203 LVQTASAKWQVSPALVMAIMQTESAFNPMAQSHVPAFGLMQIVPgSAGRDATKKVygKERLLTGAELFKPQTNIELGCAY 282
Cdd:cd16896     7 YIEKYAKEYGVDPLLVAAVIKVESNFNPNAVSSKGAIGLMQIMP-ETAEWIAEKL--GLEDFSEDDLYDPETNIRLGTWY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 283 LHILDRQYlsavtdpQSRLYCVIAAYNTGAGNVAR--AFSGNTSVKEAARRINamspkqvyahlrtrlkYEETRNYVQKV 360
Cdd:cd16896    84 LSYLLKEF-------DGNLVLALAAYNAGPGNVDKwlKDGGWSGDGKTLDQIP----------------FPETRHYVKKV 140


                  ...
gi 1713652087 361 TAA 363
Cdd:cd16896   141 LKN 143
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
196-364 2.99e-30

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 114.68  E-value: 2.99e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 196 RAQNFLPLVQTASAKWQVSPALVMAIMQTESAFNPMAQSHVPAFGLMQIVPGSAGRDATKKVyGKERLLTGAELFKPQTN 275
Cdd:PRK15470   35 RAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGLMQLKASTSGRDVYRRM-GWSGEPTTSELKNPERN 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 276 IELGCAYLHILDRQYLSAVTDPQSRLYCVIAAYNTGAGNVARAFSGNTsvKEAARRINAMSPKQVYAHLRTRLKYEETRN 355
Cdd:PRK15470  114 ISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSDR--KKAISKINDLDADEFLEHVARNHPAPQAPR 191


                  ....*....
gi 1713652087 356 YVQKVTAAL 364
Cdd:PRK15470  192 YIYKLEQAL 200
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 207-322 1.41e-28

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 107.39  E-value: 1.41e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 207 ASAKWQVSPALVMAIMQTESAFNPMAQSHVPAFGLMQIVPGSAGRDAtKKVYGKERlltgaELFKPQTNIELGCAYLHIL 286
Cdd:pfam01464   4 AAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLG-LRVNPGVD-----DLFDPEKNIKAGTKYLKEL 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1713652087 287 DRQYLsavtdpqSRLYCVIAAYNTGAGNVARAFSGN 322
Cdd:pfam01464  78 YKQYG-------GDLWLALAAYNAGPGRVRKWIKNA 106
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 215-365 6.08e-26

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 100.37  E-value: 6.08e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 215 PALVMAIMQTESAFNPMAQSHVPAFGLMQIVPGSAGRDATKKVygkerlltgAELFKPQTNIELGCAYL-HILDRQYLSa 293
Cdd:cd00254     1 PALVLAVIRVESGFNPRAVSPAGARGLMQLMPGTARDLGRRGV---------DDLFDPEENIRAGARYLrELLDRFGGD- 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1713652087 294 vtdpqsrLYCVIAAYNTGAGNVARAFSGNtsvkeaarrinamspkqvyahlrtRLKYEETRNYVQKVTAALA 365
Cdd:cd00254    71 -------LELALAAYNAGPGAVDRWGGGE------------------------VPPYKETRNYVQRVLAYYQ 111
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 192-369 4.82e-19

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 87.81  E-value: 4.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 192 ALPARAQNFLPLVQTASAKWQVSPALVMAIMQTESAFNPMAQSHVPAFGLMQIVPgsagrdATKKVYGKErlltgaELFK 271
Cdd:COG4623   256 RIEGRLPPYDPLFEKYAEEYGLDWRLLAALAYQESHWNPRARSPTGARGLMQLMP------ATAKELGVD------DRLD 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 272 PQTNIELGCAYLHILDRQYLSAVTDPQsRLYCVIAAYNTGAGNVARAfsgntsVKEAARR--------INAMSPKQVYah 343
Cdd:COG4623   324 PEQSIRAGAKYLRWLYDRFPEAIDEPD-RWWFALAAYNAGPGHVQDA------RRLAKKQgldpdrwfDVEKSQPKYY-- 394

                         170       180
                  ....*....|....*....|....*....
gi 1713652087 344 lrtRLKYE---ETRNYVQKVTAALAQYQG 369
Cdd:COG4623   395 ---DTGYArgrETVNYVPNIRAYYDIYKR 420
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 213-367 5.99e-17

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 82.42  E-value: 5.99e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 213 VSPALVMAIMQTESAFNPMAQSHVPAFGLMQIVPGSAgrDATKKVYGKERLLTGAELFKPQTNIELGCAYLHILDRQYls 292
Cdd:PRK11619  492 IPQSYAMAIARQESAWNPKARSPVGASGLMQIMPGTA--THTVKMFSIPGYSSSSQLLDPETNINIGTSYLEYVYQQF-- 567

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1713652087 293 avtdPQSRLYCViAAYNTGAGNVarafsgNTSVKEAARRINAMspkqvyAHLRTrLKYEETRNYVQKVTAALAQY 367
Cdd:PRK11619  568 ----GNNRILAS-AAYNAGPGRV------RTWLGNSAGRIDAV------AFVES-IPFSETRGYVKNVLAYDAYY 624
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 217-318 2.86e-15

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 72.57  E-value: 2.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 217 LVMAIMQTESAFNPMAQSHVPAFGLMQIVPGSAgrdATKKVYgkerlltgaELFKPQTNIELGCAYLHILDRQYlSAVTD 296
Cdd:cd13403    14 LLAAQAYQESRFNPNARSPAGARGLMQLMPSTA---RELGVN---------DRLDPEQNIHAGAKYLRYLRDRF-PPDID 80

                          90       100
                  ....*....|....*....|..
gi 1713652087 297 PQSRLYCVIAAYNTGAGNVARA 318
Cdd:cd13403    81 EPDRLKFALAAYNAGPGHVRDA 102
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 225-363 1.21e-08

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 52.91  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 225 ESAFNPMAQSHVPAFGLMQIVPGSAgrdatkKVYGK-------ERLltgaelfkpqtNIEL----GCAYLHILDRQYLSa 293
Cdd:cd16894    17 ESGFNPDAVSSAGAAGLWQFMPATA------REYGLrvdswvdERR-----------DPEKstraAARYLKDLYKRFGD- 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 294 vtdpqsrLYCVIAAYNTGAGNVARAfsgntsvkeaarrINAMSPKQVYAHLRTRLKyEETRNYVQKVTAA 363
Cdd:cd16894    79 -------WLLALAAYNAGEGRVRRA-------------IKRAGTDKWEDYYRLYLP-AETRRYVPKFLAA 127
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 213-318 5.81e-05

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 41.91  E-value: 5.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 213 VSPALVMAIMQTESAFNPMAQ-SHVPAFGLMQIVPGSA---GRDATKKvyGKERLLTGAELFKPQTNielgcaYLHILDR 288
Cdd:cd13399     3 VPPGILAAILGVESGFGPNAGgSPAGAQGIAQFMPSTWkayGVDGNGD--GKADPFNPEDAIASAAN------YLCRHGW 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 1713652087 289 QYLSAVTDPQSRlycVIAAYNTGAGNVARA 318
Cdd:cd13399    75 DLNAFLGEDNFL---ALAAYNAGPGAYANA 101
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 211-244 1.39e-04

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 40.59  E-value: 1.39e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1713652087 211 WQVSPALVMAIMQTESAFNPMAQSHVP----AFGLMQI 244
Cdd:cd13400     1 YGVPPRLLRAIAKVESGFNPNAINRNKngsyDIGLMQI 38
mltD PRK10783
membrane-bound lytic murein transglycosylase D; Provisional
 225-362 2.03e-04

membrane-bound lytic murein transglycosylase D; Provisional


Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 43.18  E-value: 2.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1713652087 225 ESAFNPMAQSHVPAFGLMQIVPgSAGRDatkkvYG--KERLLTGAELFKPQTNielgcAYLHILdrQYLSAVTDPQSRLy 302
Cdd:PRK10783  128 ESAFDPHATSGANAAGIWQIIP-STGRN-----YGlkQTRWYDARRDVVASTT-----AALDMM--QRLNKMFDGDWLL- 193

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1713652087 303 cVIAAYNTGAGNVARAFSGNtsvKEAARRINAMS---PKqvyahlrtrlkyeETRNYVQKVTA 362
Cdd:PRK10783  194 -TVAAYNSGEGRVMKAIKAN---KAKGKPTDFWSlslPR-------------ETKIYVPKMLA 239
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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