|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
1-397 |
2.16e-157 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 449.15 E-value: 2.16e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 1 MLEVADALAEVLARARPRSPQLMPLEpGNVGGVLAEDVTADRDAPPFDKSLRDGYAVRSTDRFDA---ELCVVEEIPAGV 77
Cdd:COG0303 1 MISVEEALALILAAVRPLGTETVPLA-EALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADLAGAnpvTLRVVGEIAAGS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 78 VPRKAIGPGECARIYTGAPIPAGADAVVMQEDTTAAGDRVRINAAPRPGAWVFRRGAEMRTGEVVVAAGTILTPAAIGVL 157
Cdd:COG0303 80 PPPGPLGPGEAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAGTRLTPADLGLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 158 VGVGRARIETHRFLDVGVVATGDELVGASEAPGPGQIRNTNGPMLTALACQAGTHGCDNGIARDTRESLRAVIGPALDNN 237
Cdd:COG0303 160 ASLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEALRAALREALAEA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 238 NVVLIAGGVSAGKFDLVPGVLAELGVTAHFHQVRMKPGKPLLFGTRGDTLVFGLPGNPVSALVCFELFVRPALRKMAGHA 317
Cdd:COG0303 240 DLVITSGGVSVGDYDLVKEALEELGAEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLAGLP 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 318 DPGPRVVNLPLAAAVVESNDRPTYRPAKLEPAAVGWAVRPLDGGTAPDLRGMAPADALLALPAGDARYDAGTPVRVVLIG 397
Cdd:COG0303 320 PPPPPRVRARLAEDLPKKPGRTEFLRVRLERDDGELVVEPLGGQGSGLLSSLAEADGLIVLPEGVEGVEAGEEVEVLLLD 399
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
4-396 |
1.25e-151 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 434.23 E-value: 1.25e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 4 VADALAEVLARARPRSPQLMPLEPGnVGGVLAEDVTADRDAPPFDKSLRDGYAVRSTDRFDA--ELCVVEEIPAGVVPRK 81
Cdd:cd00887 1 VEAARELLLALAPPLGTETVPLLEA-LGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTAGAsvTLRVVGEIPAGEPPDG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 82 AIGPGECARIYTGAPIPAGADAVVMQEDTTAAGDRVRINAAPRPGAWVFRRGAEMRTGEVVVAAGTILTPAAIGVLVGVG 161
Cdd:cd00887 80 PLGPGEAVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGLLASLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 162 RARIETHRFLDVGVVATGDELVGASEAPGPGQIRNTNGPMLTALACQAGTHGCDNGIARDTRESLRAVIGPALDNNNVVL 241
Cdd:cd00887 160 IAEVPVYRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALREALEEALEEADVVI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 242 IAGGVSAGKFDLVPGVLAELGVTAHFHQVRMKPGKPLLFGTRGDTLVFGLPGNPVSALVCFELFVRPALRKMAGHADPGP 321
Cdd:cd00887 240 TSGGVSVGDYDFVKEVLEELGGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQGAPEPEP 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1712586393 322 RVVNLPLAAAVVESNDRPTYRPAKLEPAAVGWAVRPLDGGTAPDLRGMAPADALLALPAGDARYDAGTPVRVVLI 396
Cdd:cd00887 320 PRVKARLAEDLKSKPGRREFLRVRLERDEGGLVVAPPGGQGSGLLSSLARADGLIVIPEGVEGLEAGEEVEVLLL 394
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
2-399 |
3.30e-97 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 302.90 E-value: 3.30e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 2 LEVADALAEVLARARPRSPQLMPLEPGnVGGVLAEDVTADRDAPPFDKSLRDGYAVRSTDRFDA------ELCVVEEIPA 75
Cdd:PRK14498 12 LEEAREILESLLSELPLGTEEVPLEEA-LGRVLAEDVYAPIDVPPFDRSAMDGYAVRAADTFGAseanpvRLKLGGEVHA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 76 GVVPRKAIGPGECARIYTGAPIPAGADAVVMQEDTTAAG-DRVRINAAPRPGAWVFRRGAEMRTGEVVVAAGTILTPAAI 154
Cdd:PRK14498 91 GEAPDVEVEPGEAVEIATGAPIPRGADAVVMVEDTEEVDdDTVEIYRPVAPGENVRPAGEDIVAGELILPKGTRLTPRDI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 155 GVLVGVGRARIETHRFLDVGVVATGDELVGASEAPGPGQIRNTNGPMLTALACQAGTHGCDNGIARDTRESLRAVIGPAL 234
Cdd:PRK14498 171 GALAAGGVAEVPVYKKPRVGIISTGDELVEPGEPLKPGKIYDVNSYTLAAAVEEAGGEPVRYGIVPDDEEELEAALRKAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 235 DNNNVVLIAGGVSAGKFDLVPGVLAELGVTaHFHQVRMKPGKPLLFGTRGDTLVFGLPGNPVSALVCFELFVRPALRKMA 314
Cdd:PRK14498 251 KECDLVLLSGGTSAGAGDVTYRVIEELGEV-LVHGVAIKPGKPTILGVIGGKPVVGLPGYPVSALTIFEEFVAPLLRKLA 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 315 GHADPGPRVVNLPLAAAVVESNDRPTYRPAKLEPAAVGWAVRPLDGG----TApdlrgMAPADALLALPAGDARYDAGTP 390
Cdd:PRK14498 330 GLPPPERATVKARLARRVRSELGREEFVPVSLGRVGDGYVAYPLSRGsgaiTS-----LVRADGFIEIPANTEGLEAGEE 404
|
....*....
gi 1712586393 391 VRVVLIGKQ 399
Cdd:PRK14498 405 VEVELFGPL 413
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
17-161 |
1.93e-42 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 145.79 E-value: 1.93e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 17 PRSPQLMPLEPGNVGG-VLAEDVTADRDAPPFDKSLRDGYAVRSTDRFDAelCVVEEIPAGVVPRKAIGPGECARIYTGA 95
Cdd:pfam03453 3 LGTEETVPLEALDALGrVLAEDVVAPRDVPPFDRSAMDGYAVRAADGFGA--SEVNPIAAGEPPGPLLPGGEAVRIMTGA 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1712586393 96 PIPAGADAVVMQEDTTAAGDR-VRINAAPRPGAWVFRRGAEMRTGEVVVAAGTILTPAAIGVLVGVG 161
Cdd:pfam03453 81 PLPEGADAVVMVEDTEEGGGRtVEIRAPVAPGENVRRAGEDIKAGEVVLPAGTRLTPAEIGLLASLG 147
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
173-308 |
4.49e-37 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 131.67 E-value: 4.49e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 173 VGVVATGDELVGASEAPGPGQIRNTNGPMLTALACQAGTHGCDNGIARDTRESLRAVIGPALDNNNVVLIAGGVSAGKFD 252
Cdd:TIGR00177 3 VAVISVGDELVEGGQPLEPGQIYDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKAVDEADVVLTTGGTGVGPRD 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1712586393 253 LVPGVLAELG----------VTAHFHQVRMKPGKPLLFGTRGDTLVFGLPGNPVSALVCFELFVRP 308
Cdd:TIGR00177 83 VTPEALEELGekeipgfgefRMLSSLPVLSRPGKPATAGVRGGTLIFNLPGNPVSALVTFEVLILP 148
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
174-305 |
1.93e-26 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 103.05 E-value: 1.93e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 174 GVVATGDELVGaseapgPGQIRNTNGPMLTALACQAGTHGCDNGIA--RDTRESLRAVIGPALDNNNVVLIAGGVSAGKF 251
Cdd:smart00852 1 AIISTGDELLS------GGQIRDSNGPMLAALLRELGIEVVRVVVVggPDDPEAIREALREALAEADVVITTGGTGPGPD 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1712586393 252 DLVPGVLAE-LGVTAHFHQVRMKPGKPLLF---------GTRGDTLVFGLPGNPVSALVCFELF 305
Cdd:smart00852 75 DLTPEALAElGGRELLGHGVAMRPGGPPGPlanlsgtapGVRGKKPVFGLPGNPVAALVMFEEL 138
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
1-397 |
2.16e-157 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 449.15 E-value: 2.16e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 1 MLEVADALAEVLARARPRSPQLMPLEpGNVGGVLAEDVTADRDAPPFDKSLRDGYAVRSTDRFDA---ELCVVEEIPAGV 77
Cdd:COG0303 1 MISVEEALALILAAVRPLGTETVPLA-EALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADLAGAnpvTLRVVGEIAAGS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 78 VPRKAIGPGECARIYTGAPIPAGADAVVMQEDTTAAGDRVRINAAPRPGAWVFRRGAEMRTGEVVVAAGTILTPAAIGVL 157
Cdd:COG0303 80 PPPGPLGPGEAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAGTRLTPADLGLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 158 VGVGRARIETHRFLDVGVVATGDELVGASEAPGPGQIRNTNGPMLTALACQAGTHGCDNGIARDTRESLRAVIGPALDNN 237
Cdd:COG0303 160 ASLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEALRAALREALAEA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 238 NVVLIAGGVSAGKFDLVPGVLAELGVTAHFHQVRMKPGKPLLFGTRGDTLVFGLPGNPVSALVCFELFVRPALRKMAGHA 317
Cdd:COG0303 240 DLVITSGGVSVGDYDLVKEALEELGAEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLAGLP 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 318 DPGPRVVNLPLAAAVVESNDRPTYRPAKLEPAAVGWAVRPLDGGTAPDLRGMAPADALLALPAGDARYDAGTPVRVVLIG 397
Cdd:COG0303 320 PPPPPRVRARLAEDLPKKPGRTEFLRVRLERDDGELVVEPLGGQGSGLLSSLAEADGLIVLPEGVEGVEAGEEVEVLLLD 399
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
4-396 |
1.25e-151 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 434.23 E-value: 1.25e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 4 VADALAEVLARARPRSPQLMPLEPGnVGGVLAEDVTADRDAPPFDKSLRDGYAVRSTDRFDA--ELCVVEEIPAGVVPRK 81
Cdd:cd00887 1 VEAARELLLALAPPLGTETVPLLEA-LGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTAGAsvTLRVVGEIPAGEPPDG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 82 AIGPGECARIYTGAPIPAGADAVVMQEDTTAAGDRVRINAAPRPGAWVFRRGAEMRTGEVVVAAGTILTPAAIGVLVGVG 161
Cdd:cd00887 80 PLGPGEAVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGLLASLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 162 RARIETHRFLDVGVVATGDELVGASEAPGPGQIRNTNGPMLTALACQAGTHGCDNGIARDTRESLRAVIGPALDNNNVVL 241
Cdd:cd00887 160 IAEVPVYRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALREALEEALEEADVVI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 242 IAGGVSAGKFDLVPGVLAELGVTAHFHQVRMKPGKPLLFGTRGDTLVFGLPGNPVSALVCFELFVRPALRKMAGHADPGP 321
Cdd:cd00887 240 TSGGVSVGDYDFVKEVLEELGGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQGAPEPEP 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1712586393 322 RVVNLPLAAAVVESNDRPTYRPAKLEPAAVGWAVRPLDGGTAPDLRGMAPADALLALPAGDARYDAGTPVRVVLI 396
Cdd:cd00887 320 PRVKARLAEDLKSKPGRREFLRVRLERDEGGLVVAPPGGQGSGLLSSLARADGLIVIPEGVEGLEAGEEVEVLLL 394
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
2-399 |
3.30e-97 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 302.90 E-value: 3.30e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 2 LEVADALAEVLARARPRSPQLMPLEPGnVGGVLAEDVTADRDAPPFDKSLRDGYAVRSTDRFDA------ELCVVEEIPA 75
Cdd:PRK14498 12 LEEAREILESLLSELPLGTEEVPLEEA-LGRVLAEDVYAPIDVPPFDRSAMDGYAVRAADTFGAseanpvRLKLGGEVHA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 76 GVVPRKAIGPGECARIYTGAPIPAGADAVVMQEDTTAAG-DRVRINAAPRPGAWVFRRGAEMRTGEVVVAAGTILTPAAI 154
Cdd:PRK14498 91 GEAPDVEVEPGEAVEIATGAPIPRGADAVVMVEDTEEVDdDTVEIYRPVAPGENVRPAGEDIVAGELILPKGTRLTPRDI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 155 GVLVGVGRARIETHRFLDVGVVATGDELVGASEAPGPGQIRNTNGPMLTALACQAGTHGCDNGIARDTRESLRAVIGPAL 234
Cdd:PRK14498 171 GALAAGGVAEVPVYKKPRVGIISTGDELVEPGEPLKPGKIYDVNSYTLAAAVEEAGGEPVRYGIVPDDEEELEAALRKAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 235 DNNNVVLIAGGVSAGKFDLVPGVLAELGVTaHFHQVRMKPGKPLLFGTRGDTLVFGLPGNPVSALVCFELFVRPALRKMA 314
Cdd:PRK14498 251 KECDLVLLSGGTSAGAGDVTYRVIEELGEV-LVHGVAIKPGKPTILGVIGGKPVVGLPGYPVSALTIFEEFVAPLLRKLA 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 315 GHADPGPRVVNLPLAAAVVESNDRPTYRPAKLEPAAVGWAVRPLDGG----TApdlrgMAPADALLALPAGDARYDAGTP 390
Cdd:PRK14498 330 GLPPPERATVKARLARRVRSELGREEFVPVSLGRVGDGYVAYPLSRGsgaiTS-----LVRADGFIEIPANTEGLEAGEE 404
|
....*....
gi 1712586393 391 VRVVLIGKQ 399
Cdd:PRK14498 405 VEVELFGPL 413
|
|
| PLN02699 |
PLN02699 |
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase |
1-396 |
5.14e-76 |
|
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase
Pssm-ID: 215376 [Multi-domain] Cd Length: 659 Bit Score: 248.19 E-value: 5.14e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 1 MLEVADALAEVLARARPRSPQLMPLEPGnVGGVLAEDVTADRDAPPFDKSLRDGYAVRSTDRfDAELCVVEEIPAGVVPR 80
Cdd:PLN02699 7 MISVEEALSIVLSVAARLSPVIVPLHEA-LGKVLAEDIRAPDPLPPYPASVKDGYAVVASDG-PGEYPVITESRAGNDGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 81 K-AIGPGECARIYTGAPIPAGADAVVMQEDTTAAGD------RVRINAAPRPGAWVFRRGAEMRTGEVVVAAGTILTPAA 153
Cdd:PLN02699 85 GvTLTPGTVAYVTTGGPIPDGADAVVQVEDTEVVEDpldgskRVRILSQASKGQDIRPVGCDIEKDAKVLKAGERLGASE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 154 IGVLVGVGRARIETHRFLDVGVVATGDELVGASEAP-GPGQIRNTNGPMLTALACQAGTHGCDNGIARDTRESLRAVIGP 232
Cdd:PLN02699 165 IGLLATVGVTMVKVYPRPTVAILSTGDELVEPTTGTlGRGQIRDSNRAMLLAAAIQQQCKVVDLGIARDDEEELERILDE 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 233 ALDNN-NVVLIAGGVSAGKFDLVPGVLAELGvTAHFHQVRMKPGKPLLF---------GTRGDTLVFGLPGNPVSALVCF 302
Cdd:PLN02699 245 AISSGvDILLTSGGVSMGDRDFVKPLLEKRG-TVYFSKVLMKPGKPLTFaeidaksapSNSKKMLAFGLPGNPVSCLVCF 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 303 ELFVRPALRKMAGHADPGPRVVNLPLAAAVVESNDRPTYRPAKLEPAAVGWAVRPldGGTAPD--------LRGMAPADA 374
Cdd:PLN02699 324 NLFVVPAIRYLAGWSNPHLLRVQARLREPIKLDPVRPEFHRAIIRWKLNDGSGNP--GFVAEStghqmssrLLSMKSANA 401
|
410 420
....*....|....*....|..
gi 1712586393 375 LLALPAGDARYDAGTPVRVVLI 396
Cdd:PLN02699 402 LLELPATGNVLSAGTSVSAIII 423
|
|
| PRK14491 |
PRK14491 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; ... |
1-393 |
1.89e-74 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional
Pssm-ID: 237729 [Multi-domain] Cd Length: 597 Bit Score: 242.60 E-value: 1.89e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 1 MLEVADALAEVLARARP-RSPQLMPLEPGNvGGVLAEDVTADRDAPPFDKSLRDGYAVRSTDRFDAELCVVEEIPAGVVP 79
Cdd:PRK14491 198 FLSVSQGLDKILSLVTPvTETEDVALDELD-GRVLAQDVISPVNVPQHTNSAMDGYAFRSDDLEPESYTLVGEVLAGHQY 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 80 RKAIGPGECARIYTGAPIPAGADAVVMQEDTTAAGDRVRINAAPRPGAWVFRRGAEMRTGEVVVAAGTILTPAAIGVLVG 159
Cdd:PRK14491 277 DGTLQAGEAVRIMTGAPVPAGADTVVMRELATQDGDKVSFDGGIKAGQNVRLAGEDLAQGQVALAAGTRLSAPEQGLLAS 356
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 160 VGRARIETHRFLDVGVVATGDELVGASEAPGPGQIRNTNGPMLTALACQAGTHGCDNGIARDTRESLRAVIGPALDNNNV 239
Cdd:PRK14491 357 LGFAEVPVFRRPKVAVFSTGDEVQAPGETLKPNCIYDSNRFTIKAMAKKLGCEVIDLGIIEDSEAALEATLEQAAAQADV 436
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 240 VLIAGGVSAGKFDLVPGVLAELGvTAHFHQVRMKPGKPLLFGTRGDTLVFGLPGNPVSALVCFELFVRPALRKMAGHADP 319
Cdd:PRK14491 437 VISSGGVSVGDADYIKTALAKLG-QIDFWRINMRPGRPLAFGQIGDSPFFGLPGNPVAVMVSFLQFVEPALRKLAGEQNW 515
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1712586393 320 GPRVVNLPLAAAVVESNDRPTYRPAKLEPAAVGWA-VRPLDGGTAPDLRGMAPADALLALPAGDARYDAGTPVRV 393
Cdd:PRK14491 516 QPLLFPAIADETLRSRQGRTEFSRGIYHLGADGRLhVRTTGKQGSGILSSMSEANCLIEIGPAAETVNAGETVTI 590
|
|
| PRK10680 |
PRK10680 |
molybdopterin biosynthesis protein MoeA; Provisional |
6-321 |
1.82e-63 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 182643 [Multi-domain] Cd Length: 411 Bit Score: 209.18 E-value: 1.82e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 6 DALAEVLARARP-RSPQLMPLePGNVGGVLAEDVTADRDAPPFDKSLRDGYAVRSTD-RFDAELCVVEEIPAGVvPRKAI 83
Cdd:PRK10680 12 TALTEMLSRVTPlTATETLPL-VQCFGRITASDIVSPLDVPGFDNSAMDGYAVRLADlASGQPLPVAGKAFAGQ-PFHGE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 84 GP-GECARIYTGAPIPAGADAVVMQEDTTAAGDRVRINAAPRPGAWVFRRGAEMRTGEVVVAAGTILTPAAIGVLVGVGR 162
Cdd:PRK10680 90 WPaGTCIRIMTGAPVPEGCEAVVMQEQTEQTDDGVRFTAEVRSGQNIRRRGEDISQGAVVFPAGTRLTTAELPVLASLGI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 163 ARIETHRFLDVGVVATGDELVGASEAPGPGQIRNTN----GPMLTALACQAgthgCDNGIARDTRESLRAVIGPALDNNN 238
Cdd:PRK10680 170 AEVPVVRKVRVALFSTGDELQLPGQPLGDGQIYDTNrlavHLMLEQLGCEV----INLGIIRDDPHALRAAFIEADSQAD 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 239 VVLIAGGVSAGKFDLVPGVLAELGvTAHFHQVRMKPGKPLLFGTRGDTLVFGLPGNPVSALVCFELFVRPALRKMAGHAD 318
Cdd:PRK10680 246 VVISSGGVSVGEADYTKTILEELG-EIAFWKLAIKPGKPFAFGKLSNSWFCGLPGNPVSAALTFYQLVQPLLAKLSGNTA 324
|
...
gi 1712586393 319 PGP 321
Cdd:PRK10680 325 SGL 327
|
|
| PRK14690 |
PRK14690 |
molybdopterin biosynthesis protein MoeA; Provisional |
4-397 |
5.84e-54 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 237789 [Multi-domain] Cd Length: 419 Bit Score: 184.35 E-value: 5.84e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 4 VADALAEVLARARPRSPQLMPLEPGNVGGVLAEDVTADRDAPPFDKSLRDGYAVRSTDRFDAELCVVEE--IPAGVVPRK 81
Cdd:PRK14690 25 VDTALDLLRARLGPVTDIKELDLSDALGHVLAHDAVALRSNPPQANSAVDGYGFAGAAPEGAQVLPLIEgrAAAGVPFSG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 82 AIGPGECARIYTGAPIPAGADAVVMQEDTTAAGDRVRINAAPRPGAWVFRRGAEMRTGEVVVAAGTILTPAAIGVLVGVG 161
Cdd:PRK14690 105 RVPEGMALRILTGAALPEGVDTVVLEEDVAGDGHRIAFHGPLKMGANTRKAGEDVIAGDVALPAGRRLTPADLALLSAVG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 162 RARIETHRFLDVGVVATGDELVGASEAPGPGQIRNTNGPMLTALACQAGTHGCDNGIARDTRESLRAVIGPALDNNNVVL 241
Cdd:PRK14690 185 LTRVSVRRPLRVAVLSTGDELVEPGALAEVGQIYDANRPMLLALARRWGHAPVDLGRVGDDRAALAARLDRAAAEADVIL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 242 IAGGVSAGKFDLVPGVLAELGVTAHFhQVRMKPGKPLLFGTRGDTLVFGLPGNPVSALVCFELFVRPALRKMAGHADPGP 321
Cdd:PRK14690 265 TSGGASAGDEDHVSALLREAGAMQSW-RIALKPGRPLALGLWQGVPVFGLPGNPVAALVCTLVFARPAMSLLAGEGWSEP 343
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1712586393 322 RVVNLPLAAAVVESNDRPTYRPAKLEPAAVgwAVRPLDGgtAPDLRGMAPADALLALPAGDARYDAGTPVRVVLIG 397
Cdd:PRK14690 344 QGFTVPAAFEKRKKPGRREYLRARLRQGHA--EVFRSEG--SGRISGLSWAEGLVELGDGARRIAPGDPVRFIPYG 415
|
|
| PRK14497 |
PRK14497 |
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional |
30-315 |
1.19e-49 |
|
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional
Pssm-ID: 172968 [Multi-domain] Cd Length: 546 Bit Score: 175.77 E-value: 1.19e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 30 VGGVLAEDVTADRDAPPFDKSLRDGYAVRStDRFDAELCVVEEIPAGVVPRKAIGPGECARIYTGAPIPAGADAVVMQED 109
Cdd:PRK14497 39 FGYVSAEDLMSPIDYPPFSRSTVDGYALKS-SCTPGEFKVIDKIGIGEFKEIHIKECEAVEVDTGSMIPMGADAVIKVEN 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 110 T-TAAGDRVRINAAPRPGAWVFRRGAEMRTGEVVVAAGTILTPAAIGVLVGVGRARIETHRFLDVGVVATGDELVGASEA 188
Cdd:PRK14497 118 TkVINGNFIKIDKKINFGQNIGWIGSDIPKGSIILRKGEVISHEKIGLLASLGISSVKVYEKPKIYLIATGDELVEPGNS 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 189 PGPGQIRNTNGPMLTALACQAGTHGCDNGIARDTRESLRAVIGPALDNNNVVLIAGGVSAGKFDLVPGVLAELGVTAhFH 268
Cdd:PRK14497 198 LSPGKIYESNLHYLYSKLKSEGYKIVGLSLLSDDKESIKNEIKRAISVADVLILTGGTSAGEKDFVHQAIRELGNII-VH 276
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1712586393 269 QVRMKPGKPLLFGTRGDTLVFGLPGNPVSALVCFELFVRPALRKMAG 315
Cdd:PRK14497 277 GLKIKPGKPTILGIVDGKPVIGLPGNIVSTMVVLNMVILEYLKSLYP 323
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
17-161 |
1.93e-42 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 145.79 E-value: 1.93e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 17 PRSPQLMPLEPGNVGG-VLAEDVTADRDAPPFDKSLRDGYAVRSTDRFDAelCVVEEIPAGVVPRKAIGPGECARIYTGA 95
Cdd:pfam03453 3 LGTEETVPLEALDALGrVLAEDVVAPRDVPPFDRSAMDGYAVRAADGFGA--SEVNPIAAGEPPGPLLPGGEAVRIMTGA 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1712586393 96 PIPAGADAVVMQEDTTAAGDR-VRINAAPRPGAWVFRRGAEMRTGEVVVAAGTILTPAAIGVLVGVG 161
Cdd:pfam03453 81 PLPEGADAVVMVEDTEEGGGRtVEIRAPVAPGENVRRAGEDIKAGEVVLPAGTRLTPAEIGLLASLG 147
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
173-308 |
4.49e-37 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 131.67 E-value: 4.49e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 173 VGVVATGDELVGASEAPGPGQIRNTNGPMLTALACQAGTHGCDNGIARDTRESLRAVIGPALDNNNVVLIAGGVSAGKFD 252
Cdd:TIGR00177 3 VAVISVGDELVEGGQPLEPGQIYDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKAVDEADVVLTTGGTGVGPRD 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1712586393 253 LVPGVLAELG----------VTAHFHQVRMKPGKPLLFGTRGDTLVFGLPGNPVSALVCFELFVRP 308
Cdd:TIGR00177 83 VTPEALEELGekeipgfgefRMLSSLPVLSRPGKPATAGVRGGTLIFNLPGNPVSALVTFEVLILP 148
|
|
| MoCF_biosynth |
pfam00994 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
174-312 |
1.06e-30 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerization.
Pssm-ID: 425979 [Multi-domain] Cd Length: 143 Bit Score: 114.65 E-value: 1.06e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 174 GVVATGDELVgaseapgPGQIRNTNGPMLTALACQAGTHGCDNGIARDTRESLRAVIGPALDNNNVVLIAGGVSAGKFDL 253
Cdd:pfam00994 1 AIITTGDELL-------PGQIRDTNGPLLAALLREAGAEVIRYGIVPDDPEAIKEALRAAAEEADVVITTGGTGPGPDDV 73
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 254 VPGVLAELGVT------AHFHQVRMKPGKPLLFGT-----RGDTLVFGLPGNPVSALVCFELFVRPALRK 312
Cdd:pfam00994 74 TPEALAELGGRelpgfeELFRGVSLKPGKPVGTAPgailsRAGKTVFGLPGSPVAAKVMFELLLLPLLRH 143
|
|
| MoCF_BD |
cd00758 |
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of ... |
173-310 |
2.83e-27 |
|
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin.
Pssm-ID: 238387 [Multi-domain] Cd Length: 133 Bit Score: 105.12 E-value: 2.83e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 173 VGVVATGDELVgaseapgPGQIRNTNGPMLTALACQAGTHGCDNGIARDTRESLRAVIGPALDNNNVVLIAGGVSAGKFD 252
Cdd:cd00758 2 VAIVTVSDELS-------QGQIEDTNGPALEALLEDLGCEVIYAGVVPDDADSIRAALIEASREADLVLTTGGTGVGRRD 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1712586393 253 LVPGVLAELG-VTAHFHQVRMKPGKPLLFGTRGDTLVFGLPGNPVSALVCFELFVRPAL 310
Cdd:cd00758 75 VTPEALAELGeREAHGKGVALAPGSRTAFGIIGKVLIINLPGSPKSALTTFEALVLPAL 133
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
174-305 |
1.93e-26 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 103.05 E-value: 1.93e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712586393 174 GVVATGDELVGaseapgPGQIRNTNGPMLTALACQAGTHGCDNGIA--RDTRESLRAVIGPALDNNNVVLIAGGVSAGKF 251
Cdd:smart00852 1 AIISTGDELLS------GGQIRDSNGPMLAALLRELGIEVVRVVVVggPDDPEAIREALREALAEADVVITTGGTGPGPD 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1712586393 252 DLVPGVLAE-LGVTAHFHQVRMKPGKPLLF---------GTRGDTLVFGLPGNPVSALVCFELF 305
Cdd:smart00852 75 DLTPEALAElGGRELLGHGVAMRPGGPPGPlanlsgtapGVRGKKPVFGLPGNPVAALVMFEEL 138
|
|
| MoeA_C |
pfam03454 |
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis ... |
325-396 |
4.40e-05 |
|
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this domain is uncertain. The structure of this domain is known and forms an incomplete beta barrel.
Pssm-ID: 460924 [Multi-domain] Cd Length: 72 Bit Score: 41.44 E-value: 4.40e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1712586393 325 NLPLAAAVVESNDRPTYRPAKLEPAAVGWAVRPLDGGTAPDLRGMAPADALLALPAGDARYDAGTPVRVVLI 396
Cdd:pfam03454 1 KARLARDLKSDPGRREFVRVRLHEEDGRYYAEPIGKQGSGMLSSLAEANGLIVVPEGTEGLEAGEEVEVILL 72
|
|
| |
