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Conserved domains on  [gi|1712582547|ref|WP_143763719|]
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MULTISPECIES: DHA2 family efflux MFS transporter permease subunit [Paenibacillus]

Protein Classification

efflux MFS transporter permease( domain architecture ID 1000855)

efflux MFS (major facilitator superfamily) transporter permease, similar to Escherichia coli multidrug efflux pump EmrB and Neisseria gonorrhoeae fatty acid resistance protein FarB

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
efflux_EmrB super family cl31024
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 1-454 2.35e-102

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00711:

Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 314.70  E-value: 2.35e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAI 80
Cdd:TIGR00711   7 LMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  81 AASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPT 160
Cdd:TIGR00711  87 APNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 161 VVVIVCGFIYLKNVSKRSYPKLDMISVALSTIGFGSLLYGFSRAGSAGWTSAEVLLALG-AGTLSLGLFIWRQLASHNPL 239
Cdd:TIGR00711 167 IIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSiTGLVAIIAFVVWELTDDNPL 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 240 LDLRAFKYNMFSLTTVISIAVTIVMYADMILLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLAII 319
Cdd:TIGR00711 247 VDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTI 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 320 GLLITISTTLSF-INLTDSTSYIYLVFMSTGRQIGMAMFLMPIQTAGLNQLPAKLNAHGTAISNTVKQVAGAIGTSLLVT 398
Cdd:TIGR00711 327 GLILYAVGFYWRaFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALITT 406

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1712582547 399 IMMSRTATHMQQL----------------------MATNVAKSATQDHMMMEATIQGINDAYLVIVGIGILGLLLSFF 454
Cdd:TIGR00711 407 ILTNRTQFHHSQLtetinpvnpnflsgysqlaalgNPEQQVYALIAQQITLHAFSIAINEIFWMATLLFVSGLILIWF 484
 
Name Accession Description Interval E-value
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 1-454 2.35e-102

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 314.70  E-value: 2.35e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAI 80
Cdd:TIGR00711   7 LMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  81 AASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPT 160
Cdd:TIGR00711  87 APNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 161 VVVIVCGFIYLKNVSKRSYPKLDMISVALSTIGFGSLLYGFSRAGSAGWTSAEVLLALG-AGTLSLGLFIWRQLASHNPL 239
Cdd:TIGR00711 167 IIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSiTGLVAIIAFVVWELTDDNPL 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 240 LDLRAFKYNMFSLTTVISIAVTIVMYADMILLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLAII 319
Cdd:TIGR00711 247 VDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTI 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 320 GLLITISTTLSF-INLTDSTSYIYLVFMSTGRQIGMAMFLMPIQTAGLNQLPAKLNAHGTAISNTVKQVAGAIGTSLLVT 398
Cdd:TIGR00711 327 GLILYAVGFYWRaFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALITT 406

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1712582547 399 IMMSRTATHMQQL----------------------MATNVAKSATQDHMMMEATIQGINDAYLVIVGIGILGLLLSFF 454
Cdd:TIGR00711 407 ILTNRTQFHHSQLtetinpvnpnflsgysqlaalgNPEQQVYALIAQQITLHAFSIAINEIFWMATLLFVSGLILIWF 484
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 1-456 7.86e-96

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 294.10  E-value: 7.86e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAI 80
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  81 AASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPT 160
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 161 VVVIVCGfiylknvskrsypkldmisvalstigfgsllygfsragsagwtsaevllalgagtlslglfiwrqlashnPLL 240
Cdd:cd17503   161 ILALLLA----------------------------------------------------------------------PLL 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 241 DLRAFKYNMFSLTTVISIAVTIVMYADMILLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLAIIG 320
Cdd:cd17503   171 DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 321 LLITISTTLSFINLTDSTSYIYLVFMSTGRQIGMAMFLMPIQTAGLNQLPAKLNAHGTAISNTVKQVAGAIGTSLLVTIM 400
Cdd:cd17503   251 LLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLL 330

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1712582547 401 MSRTATHMQQLMATNVAKSATQdhmmmeATIQGINDAYLVIVGIGILGLLLSFFIK 456
Cdd:cd17503   331 TNRTQFHHSRLSELLAQQVQKQ------ALIIAFNDAFLVSAILLLVGLLLALFLR 380
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-391 2.08e-32

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 126.24  E-value: 2.08e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAI 80
Cdd:COG2814    15 LALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  81 AASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPT 160
Cdd:COG2814    95 APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLA 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 161 VVVIVCGFIYLKNVSKRSYPKLDMISVALstigfgsllygfsragsagwtsaevllalgagtlslglfiwrqlashnpll 240
Cdd:COG2814   175 LLALLLLLRLLPESRPAARARLRGSLREL--------------------------------------------------- 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 241 dlraFKYNMFSLTTVISIAVTIVMYADMILLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLAIIG 320
Cdd:COG2814   204 ----LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG 279

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1712582547 321 LLITIsttLSFINLTDSTSYIYLVFMSTGRQIGMAMFLMPIQTAGLNQLPAKLNAHGTAISNTVKQVAGAI 391
Cdd:COG2814   280 LLLLA---LGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
1-393 7.13e-23

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 99.41  E-value: 7.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPE-LMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAA 79
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  80 IAASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPP 159
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 160 TVVVIVCGFIYLKNVSKRSYPKldmisvalstigfgsllygfsragsagwtsaevllalgagtlslglfiwRQLASHNPL 239
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKP-------------------------------------------------AEEARLSLI 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 240 LDLRAFKYNMFSLTTVISIAVTIVMYADMILLPLYLQSaRGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLAII 319
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1712582547 320 GLLITISTTLSFINLTDSTSYIYLVFMSTGRQIGMAMFLMPIQTAGLNQLPAKLNAHGTAISNTVKQVAGAIGT 393
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
PRK14995 PRK14995
SmvA family efflux MFS transporter;
9-334 1.57e-20

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 94.02  E-value: 1.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   9 TLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLV-NGVLIPITAyLMQRFTTRQLFQTSMFIFLTGTIVAAIAASFPVL 87
Cdd:PRK14995   19 AIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVmAGMVLPMGA-LGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  88 LTGRLIQATGAGIIMPLLINVILTLFPPEK-RGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPTVVVIVC 166
Cdd:PRK14995   98 IATRALLAIGAAMIVPATLAGIRATFTEEKqRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGL 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 167 GFIYLKNVSKRSYPKLDMISVALSTIGFGSLLYGFSRAGSAGWTSAEVLLALGAGTLSLGLFIWRQLASHNPLLDLRAFK 246
Cdd:PRK14995  178 TARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFT 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 247 YNMFSLTTVISIAVTIVMYADMILLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLAIIGLLItis 326
Cdd:PRK14995  258 HRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGMAL--- 334


                  ....*...
gi 1712582547 327 TTLSFINL 334
Cdd:PRK14995  335 SALSFYGL 342
 
Name Accession Description Interval E-value
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 1-454 2.35e-102

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 314.70  E-value: 2.35e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAI 80
Cdd:TIGR00711   7 LMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  81 AASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPT 160
Cdd:TIGR00711  87 APNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 161 VVVIVCGFIYLKNVSKRSYPKLDMISVALSTIGFGSLLYGFSRAGSAGWTSAEVLLALG-AGTLSLGLFIWRQLASHNPL 239
Cdd:TIGR00711 167 IIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSiTGLVAIIAFVVWELTDDNPL 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 240 LDLRAFKYNMFSLTTVISIAVTIVMYADMILLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLAII 319
Cdd:TIGR00711 247 VDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTI 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 320 GLLITISTTLSF-INLTDSTSYIYLVFMSTGRQIGMAMFLMPIQTAGLNQLPAKLNAHGTAISNTVKQVAGAIGTSLLVT 398
Cdd:TIGR00711 327 GLILYAVGFYWRaFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALITT 406

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1712582547 399 IMMSRTATHMQQL----------------------MATNVAKSATQDHMMMEATIQGINDAYLVIVGIGILGLLLSFF 454
Cdd:TIGR00711 407 ILTNRTQFHHSQLtetinpvnpnflsgysqlaalgNPEQQVYALIAQQITLHAFSIAINEIFWMATLLFVSGLILIWF 484
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 1-456 7.86e-96

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 294.10  E-value: 7.86e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAI 80
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  81 AASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPT 160
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 161 VVVIVCGfiylknvskrsypkldmisvalstigfgsllygfsragsagwtsaevllalgagtlslglfiwrqlashnPLL 240
Cdd:cd17503   161 ILALLLA----------------------------------------------------------------------PLL 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 241 DLRAFKYNMFSLTTVISIAVTIVMYADMILLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLAIIG 320
Cdd:cd17503   171 DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 321 LLITISTTLSFINLTDSTSYIYLVFMSTGRQIGMAMFLMPIQTAGLNQLPAKLNAHGTAISNTVKQVAGAIGTSLLVTIM 400
Cdd:cd17503   251 LLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLL 330

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1712582547 401 MSRTATHMQQLMATNVAKSATQdhmmmeATIQGINDAYLVIVGIGILGLLLSFFIK 456
Cdd:cd17503   331 TNRTQFHHSRLSELLAQQVQKQ------ALIIAFNDAFLVSAILLLVGLLLALFLR 380
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 1-456 5.02e-44

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 158.49  E-value: 5.02e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAI 80
Cdd:cd17321     1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  81 AASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPT 160
Cdd:cd17321    81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 161 VVVIVCGfiylknvskrsypkldmisvalstigfgsllygfsragsagwtsaevllalgagtlslglfiwrqlashnpll 240
Cdd:cd17321   161 LVALLLA------------------------------------------------------------------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 241 dlrafkyNMFSLTTVISIAVTIVMYADMILLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLAIIG 320
Cdd:cd17321   168 -------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAG 240

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 321 LLITISTTLSFINLTDSTSYIYLVFMSTGRQIGMAMFLMPIQTAGLNQLPAKLNAHGTAISNTVKQVAGAIGTSLLVTIM 400
Cdd:cd17321   241 LLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALL 320

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1712582547 401 MSRTATHMQQLMATNVAKSATQdhmmmeATIQGINDAYLVIVGIGILGLLLSFFIK 456
Cdd:cd17321   321 TAGLSANLGDSGVAALLSAAAA------AFAAGFHLAFLVAAALALLAALLALLLP 370
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-391 2.08e-32

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 126.24  E-value: 2.08e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAI 80
Cdd:COG2814    15 LALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  81 AASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPT 160
Cdd:COG2814    95 APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLA 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 161 VVVIVCGFIYLKNVSKRSYPKLDMISVALstigfgsllygfsragsagwtsaevllalgagtlslglfiwrqlashnpll 240
Cdd:COG2814   175 LLALLLLLRLLPESRPAARARLRGSLREL--------------------------------------------------- 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 241 dlraFKYNMFSLTTVISIAVTIVMYADMILLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLAIIG 320
Cdd:COG2814   204 ----LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG 279

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1712582547 321 LLITIsttLSFINLTDSTSYIYLVFMSTGRQIGMAMFLMPIQTAGLNQLPAKLNAHGTAISNTVKQVAGAI 391
Cdd:COG2814   280 LLLLA---LGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 2-456 1.25e-25

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 107.66  E-value: 1.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   2 IFGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIA 81
Cdd:cd17504     2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  82 ASFPVLLTGRLIQATGAGIImPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPTV 161
Cdd:cd17504    82 PNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 162 VVIVCgfiylknvskrsypkldmisvalstigfgsllygfsragsagwtsaevllalgagtlslglfiwrqlashNPLLD 241
Cdd:cd17504   161 LLAAL----------------------------------------------------------------------VPLID 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 242 LRAFKYNMFSLTTVISIAVTIVMYADMILLPLYLQSARGY----SAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLA 317
Cdd:cd17504   171 LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTgfglGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVL 250

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 318 IIGLLITISTTLSFinLTDSTSYIYLVFMSTGRQIGMAMFLMPIQTAGLNQLPAKLNAHGTAISNTVKQVAGAIGTSLLV 397
Cdd:cd17504   251 LIGLVISAVGLLLL--ALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAG 328

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1712582547 398 TIMMSRTATHMQQLMATNVAKSAtqdhmmmeatiqgindAYLVIVGIGILGLLLSFFIK 456
Cdd:cd17504   329 AILTTYTVSITSGGVPTEGAYVL----------------AFLIGAALALAALLLSLLIP 371
MFS_1 pfam07690
Major Facilitator Superfamily;
1-393 7.13e-23

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 99.41  E-value: 7.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPE-LMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAA 79
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  80 IAASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPP 159
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 160 TVVVIVCGFIYLKNVSKRSYPKldmisvalstigfgsllygfsragsagwtsaevllalgagtlslglfiwRQLASHNPL 239
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKP-------------------------------------------------AEEARLSLI 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 240 LDLRAFKYNMFSLTTVISIAVTIVMYADMILLPLYLQSaRGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLAII 319
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1712582547 320 GLLITISTTLSFINLTDSTSYIYLVFMSTGRQIGMAMFLMPIQTAGLNQLPAKLNAHGTAISNTVKQVAGAIGT 393
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 4-398 1.72e-22

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 98.02  E-value: 1.72e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   4 GAFLATLNQTVMGVAMPELMNDFNiSAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAAS 83
Cdd:cd17502     4 ALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPN 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  84 FPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPTVVV 163
Cdd:cd17502    83 MTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 164 IVcgfiylknvskrsypkldMISVALSTIGFGSLLYGFsragsagwtsaevllalgagtlslglfiwrqlashnplldlr 243
Cdd:cd17502   163 LA------------------LLRTILLSSIFGFLFGGA------------------------------------------ 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 244 afkynmfslttvisiavtivMYADMILLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFG-AKWLAIIGLL 322
Cdd:cd17502   183 --------------------LFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVIGTI 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 323 ITISTTLSFINLTDSTSYI----YLVFMSTGRQIGMAMFLMPIQtaglNQLPAKLNAHGTAISNTVKQVAGAIGTSLLVT 398
Cdd:cd17502   243 LMSVGAGLLTTLTLDTSKWlligYLILLGLGLGIGFQQPLVAVQ----NAVPPADVGVATATNTFFRSLGGTLGVAITDV 318
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 1-275 3.48e-22

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 96.42  E-value: 3.48e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAI 80
Cdd:COG0477    19 LALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  81 AASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPT 160
Cdd:COG0477    99 APSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLG 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 161 VVVIVCGFIYLKNVSKRSYPKLDMISVALSTIGFGSLLYGFSRAGSAGWTSAEVLLALGAGTLSLGLFIWRQLASHNPLL 240
Cdd:COG0477   179 LLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLL 258

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1712582547 241 DLRAFKYNMFSLTTVISIAVTIVMYADMILLPLYL 275
Cdd:COG0477   259 LAALLLLLLLLLLLALLLALLLLLLLLLLLLLLAL 293
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 1-419 4.39e-22

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 98.85  E-value: 4.39e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMNDFNISAATAqWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAI 80
Cdd:cd06179     3 LCLAYFAQLFGVTLPAAVLPFIVADLGPSSNST-WISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  81 AASFPVLLTGRLIQATGAGIImPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHY--SWETMFY-GII 157
Cdd:cd06179    82 AKSVNMLIGGQALIGIGAGTQ-GLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRWIFYiNAI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 158 PPTVVVIVCGFIY-------LKNVSKRSYPK-LDMISVALSTIGFGSLLYGFSRAGSA-GWTSAEVL--LALGAGTLsLG 226
Cdd:cd06179   161 FNALALILLFFFYhppprpqLHGSSTRQKLKrLDWVGLFLLIAGLVLFLLGLSWGGNPyPWSSAHVIapLVIGGVLL-IA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 227 LFIWRQLASHNPLLDLRAFKYNM-FSLTTVISIAVTIVMYADMILLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTG 305
Cdd:cd06179   240 FGLYEWKGTKDGLLPPRLLFRGRnFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAG 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 306 KLFDRFG-AKWLAIIGLLITISTT--LSFINLTDSTSYIYLVFMSTgrqIGMAMFLMPIQTAGLNQLPAKLNAHGTAISN 382
Cdd:cd06179   320 LLLTKIKhIKWQLVAGFVLFTAFLalLALITPDNKALAIAFSVLAG---IGIGGPLVLAIVIVQLSVPPEDIGTASGLLG 396

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1712582547 383 TVKQVAGAIGTSLLVTIMMSRTATHMQQLMATNVAKS 419
Cdd:cd06179   397 SARALGGAVGTAIFTSILSNRLSKNLPARVAPAALEA 433
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-400 1.01e-21

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 96.48  E-value: 1.01e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAI 80
Cdd:COG2271    15 LFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  81 AASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPT 160
Cdd:COG2271    95 ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPG 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 161 VVVIVCGFIYLknvskrsypkldmisvalstigfgsllygfsragsagwtsaevllalgagtlslglfiwrqlashnpll 240
Cdd:COG2271   175 LLLALLRFWLL--------------------------------------------------------------------- 185

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 241 dlrafkynmfsltTVISIAVTIVMYADMILLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGA--KWLAI 318
Cdd:COG2271   186 -------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLA 252

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 319 IGLLITISTTLSFINLTDSTSYIYLVFMSTgrqIGMAMFLMPIQTAGLNQLPAKLNAHGTAISNTVKQVAGAIGTSLLVT 398
Cdd:COG2271   253 IGLLLAALALLLLALLPSPALAIALLFLAG---FGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGY 329


                  ..
gi 1712582547 399 IM 400
Cdd:COG2271   330 LL 331
PRK14995 PRK14995
SmvA family efflux MFS transporter;
9-334 1.57e-20

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 94.02  E-value: 1.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   9 TLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLV-NGVLIPITAyLMQRFTTRQLFQTSMFIFLTGTIVAAIAASFPVL 87
Cdd:PRK14995   19 AIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVmAGMVLPMGA-LGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  88 LTGRLIQATGAGIIMPLLINVILTLFPPEK-RGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPTVVVIVC 166
Cdd:PRK14995   98 IATRALLAIGAAMIVPATLAGIRATFTEEKqRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGL 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 167 GFIYLKNVSKRSYPKLDMISVALSTIGFGSLLYGFSRAGSAGWTSAEVLLALGAGTLSLGLFIWRQLASHNPLLDLRAFK 246
Cdd:PRK14995  178 TARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFT 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 247 YNMFSLTTVISIAVTIVMYADMILLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLAIIGLLItis 326
Cdd:PRK14995  258 HRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGMAL--- 334


                  ....*...
gi 1712582547 327 TTLSFINL 334
Cdd:PRK14995  335 SALSFYGL 342
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 3-392 3.20e-19

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 89.17  E-value: 3.20e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   3 FGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAA 82
Cdd:cd17325     3 LALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  83 SFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPTVV 162
Cdd:cd17325    83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 163 VIVCGFIYLKNVSKRSYPKLDMISVALSTIgfgsllygfsragsagwtsaevllalgagtlslglfiwrqlashnplldL 242
Cdd:cd17325   163 ALVLALLLLPEPRPPPNKRAVSAARLRSGL-------------------------------------------------R 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 243 RAFKYNMFSLTTVISIAVTIVMYADMILLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLAIIGLL 322
Cdd:cd17325   194 LLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLL 273

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 323 ItisTTLSFINLTDSTSYIYLVFMSTGRQIGMAMFLMPIQTAGLNQLPAKLNAHGTAISNTVKQVAGAIG 392
Cdd:cd17325   274 L---SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG 340
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
2-396 7.02e-19

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 88.40  E-value: 7.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   2 IFGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIA 81
Cdd:COG2223    11 TLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  82 ASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPTV 161
Cdd:COG2223    91 VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 162 VVIVCGFIYLKNVSKrsypkldmisvalstigfgsllyGFSRAGSAGWTSAevllalgagtlslglfiwrqlashnplld 241
Cdd:COG2223   171 VVAVLAWLFLRDPPA-----------------------GAAAAAKASLRDQ----------------------------- 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 242 LRAFKYNMFSLTTVISIAVTIVMYADMILLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLAIIGL 321
Cdd:COG2223   199 LEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVF 278

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1712582547 322 LITISTTLSFINLTDSTSYIYLVFMSTGRQIGMAMFLMPIQTAGLNqlPAKLNAHGTAISNTVKQVAGAIGTSLL 396
Cdd:COG2223   279 ALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIF--PTKNAGAVYGLVGAAGGLGGFLGPLLF 351
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 3-198 2.17e-18

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 86.47  E-value: 2.17e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   3 FGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAA 82
Cdd:cd17474     6 FATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  83 SFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHySWETMFYGIIPPTVV 162
Cdd:cd17474    86 SFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAALIPV 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1712582547 163 VIVCGFIYLKNVSKR----SYPKLDMISVALSTIGFGSLL 198
Cdd:cd17474   165 AFLAILFLLPEPKEKakssSATKLRDLKKALRGRGLLTFL 204
PRK10504 PRK10504
putative transporter; Provisional
 1-282 4.23e-18

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 86.71  E-value: 4.23e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAI 80
Cdd:PRK10504   15 VAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  81 AASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPT 160
Cdd:PRK10504   95 SGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVG 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 161 VVVIVCGFIYLKNVSKRSYpKLDMISVALSTIGFGSLLYGFSRAGSAGWTSAEVLLALGAGTLSLGLFIWRQLASHNPLL 240
Cdd:PRK10504  175 IIGAIATLMLMPNYTMQTR-RFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNRALF 253

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1712582547 241 DLRAFKYNMFSLTTVISIAVTIVMYADMILLPLYLQSARGYS 282
Cdd:PRK10504  254 SLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFS 295
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 1-156 6.22e-17

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 82.21  E-value: 6.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAI 80
Cdd:cd17324     4 LALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1712582547  81 AASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGI 156
Cdd:cd17324    84 APSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAI 159
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 1-154 2.19e-14

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 74.53  E-value: 2.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAI 80
Cdd:cd17320     4 LALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCAL 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1712582547  81 AASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFY 154
Cdd:cd17320    84 ASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFV 157
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 3-202 7.73e-14

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 72.60  E-value: 7.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   3 FGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAA 82
Cdd:cd17319    10 LAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFAT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  83 SFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPTVV 162
Cdd:cd17319    90 SLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLL 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1712582547 163 VIVCGFIYLKNvskrsypkldMISVALSTIGFGSLLYGFS 202
Cdd:cd17319   170 LAVLWWFYLRQ----------VWGLALGYFGINYALYGLL 199
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
1-173 6.40e-13

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 70.29  E-value: 6.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLN----QTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTI 76
Cdd:COG2807    19 LLLAIVLVALNlrpaITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  77 VAAIAASFPVLLTGRLIQATGAGIIMPLLINVILTLFpPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGI 156
Cdd:COG2807    99 LRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVW 177

                         170
                  ....*....|....*..
gi 1712582547 157 IPPTVVVIVCGFIYLKN 173
Cdd:COG2807   178 ALLALLALLLWLPLLRR 194
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 3-396 1.47e-12

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 68.99  E-value: 1.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   3 FGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAA 82
Cdd:cd06174     3 LGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  83 SFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEH--YSWETMFYGIIPPT 160
Cdd:cd06174    83 SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 161 VVVIVCGFIYLKNVSKRSYPKLDMISVALSTIGFGSLlygfsragsagwtsaevllalgagtlslglfiwrqlashnpll 240
Cdd:cd06174   163 LLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRV------------------------------------------- 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 241 dlraFKYNMFSLTTVISIAVTIVMYADMILLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLAIIG 320
Cdd:cd06174   200 ----LKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLI 275

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1712582547 321 LLITISTTLSFINLTDSTSYIYLVFMSTGrqIGMAMFLMPIQTAGLNQLPAKLNAHGTAISNTVKQVAGAIGTSLL 396
Cdd:cd06174   276 GLLLMALGLALLLLAPSLLLLLLLLLLLG--FGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLA 349
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 1-171 1.17e-10

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 62.98  E-value: 1.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAI 80
Cdd:cd17323     4 ISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  81 AASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYgiippt 160
Cdd:cd17323    84 APNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFW------ 157

                         170
                  ....*....|.
gi 1712582547 161 VVVIVCGFIYL 171
Cdd:cd17323   158 FLAIISGFCLI 168
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 14-360 5.28e-10

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 61.22  E-value: 5.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  14 VMGVAMPELMNDFNISAATAQWLTTGY---MLVNGVLIpitAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAASFPVLLTG 90
Cdd:TIGR00895  35 AMGFAAPAISAEWGLDPVQLGFLFSAGligMAFGALFF---GPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLIL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  91 RLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFY--GIIPPTVVVIVCGF 168
Cdd:TIGR00895 112 RFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYvgGIAPLLLLLLLMRF 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 169 -----IYLknVSKRSYPKLDMISVALSTIGFGSlLYGFSRAGSAGWTSAEVLLALGAGTLSLG-LFIWrqlashnplldl 242
Cdd:TIGR00895 192 lpesiDFL--VSKRPETVRRIVNAIAPQMQAEA-QSALPEQKSTQGTKRSVFKALFQGKTARItVLLW------------ 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 243 rafkynmfslttvISIAVTIVM-YADMILLPlYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLAIIGL 321
Cdd:TIGR00895 257 -------------LLYFMLLVGvYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLL 322

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1712582547 322 LITISTTLSFINLTDSTSYIYLV----FMSTGRQIGMaMFLMP 360
Cdd:TIGR00895 323 LGAVFAVLVGSTLFSPTLLLLLGaiagFFVNGGQSGL-YALMA 364
2_A_01_02 TIGR00880
Multidrug resistance protein;
35-154 6.89e-10

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 57.27  E-value: 6.89e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  35 WLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAASFPVLLTGRLIQATGAGIIMPLLINVILTLFP 114
Cdd:TIGR00880   2 LLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1712582547 115 PEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFY 154
Cdd:TIGR00880  82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFL 121
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 5-212 3.69e-09

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 58.55  E-value: 3.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   5 AFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAASF 84
Cdd:TIGR00710  14 SILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNI 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  85 PVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPTVVVI 164
Cdd:TIGR00710  94 ETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLS 173

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1712582547 165 VCGFIYLKNvskrSYPKLDMISVALSTIGFGSLL-----------YGFSRAGSAGWTSA 212
Cdd:TIGR00710 174 ALIFFILPE----TLPYEARIQISTYFETFLLLLkskmfwgyaliYGASFGGFFAFFSG 228
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 22-171 1.48e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 56.43  E-value: 1.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  22 LMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAASFPVLLTGRLIQATGAGII 101
Cdd:cd17325   226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLV 305

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 102 MPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIpptVVVIVCGFIYL 171
Cdd:cd17325   306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAA---ALLLLAAVLFL 372
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-176 2.01e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 56.03  E-value: 2.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMND-FNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQ--LFQTSMFIFLTGTIV 77
Cdd:COG2271   185 LALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLL 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  78 AAIAASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGII 157
Cdd:COG2271   265 LALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLA 344

                         170
                  ....*....|....*....
gi 1712582547 158 PPTVVVIVCGFIYLKNVSK 176
Cdd:COG2271   345 ALALLAALLALLLLRETRK 363
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 12-163 6.64e-08

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 54.55  E-value: 6.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  12 QTVMGVAmPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAASFPVLLTGR 91
Cdd:cd17328    16 FTIAGVL-PDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFR 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1712582547  92 LIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEH-YSWETMFYGIIPPTVVV 163
Cdd:cd17328    95 ALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLL 167
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 2-154 2.53e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 52.58  E-value: 2.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   2 IFGAFLATLNQTVMGVAMPELMNDF-NISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAI 80
Cdd:cd17473     5 LLASTLTVMAGAAIAPALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLF 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1712582547  81 AASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEhYSWETMFY 154
Cdd:cd17473    85 LDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFL 157
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 13-164 3.31e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 52.20  E-value: 3.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  13 TVMGVAMPELMNDFNISAATAQWL-TTGY--MLVNGVLIPITAylmQRFTTRQLFQTSMFIFLTGTIVAAIAASFPVLLT 89
Cdd:cd17365    16 AVMGFVAPALAQDWGLSPAQLGPVgSAALfgMAIGALLAGPLA---DRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1712582547  90 GRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFY-GIIPPTVVVI 164
Cdd:cd17365    93 LRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLlGGVPPLILLP 168
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 45-171 4.42e-07

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 51.80  E-value: 4.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  45 GVLIPITAYLM-----QRFTTRQLFQTSMFIFLTGTIVAAIAASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRG 119
Cdd:cd17474   244 SVLLALGSLFVgrllkKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERG 323

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1712582547 120 AAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIppTVVVIVCGFIYL 171
Cdd:cd17474   324 TASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGA--AIALAAAVLLAL 373
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 25-169 4.53e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.83  E-value: 4.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  25 DFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAASFPVLLTGRLIQATGAGIIMPL 104
Cdd:cd17489    25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1712582547 105 LINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPTVVVIVCGFI 169
Cdd:cd17489   105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFL 169
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 6-199 6.35e-07

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 51.49  E-value: 6.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   6 FLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAASFP 85
Cdd:cd17476     8 LLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFI 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  86 VLLTGRLIQATGAGIIMPLLINVILTLFPPEK-RGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIippTVVVI 164
Cdd:cd17476    88 FFIICRALQGLGPAFLLPNAMALLGRTYPPGPrKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFL---AILAA 164

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1712582547 165 VCGFIYLknVSKRSYPKLDMISVALSTIGFGSLLY 199
Cdd:cd17476   165 IVAVAAI--FWTSPSFIAVLLAVFLGWASFGIWVF 197
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 1-166 1.53e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 50.25  E-value: 1.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAI 80
Cdd:cd17478     1 LSLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  81 AASFPVLLTGRLIQATGAGIIMPLLInVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPT 160
Cdd:cd17478    81 APNYWLLLLLVALAGIGSAAFHPEGA-RLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPG 159


                  ....*.
gi 1712582547 161 VVVIVC 166
Cdd:cd17478   160 LAVALL 165
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 3-144 2.36e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 49.49  E-value: 2.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   3 FGAFLATLNQTVMGVAMPELMNDFNI-SAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIA 81
Cdd:cd17473   204 FLAFLAMLLFYVIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALA 283

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1712582547  82 ASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVL 144
Cdd:cd17473   284 SGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLV 346
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 43-394 4.64e-06

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 48.84  E-value: 4.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  43 VNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAASFPVLLTGRLIQA---TGAGIIMPLLINVILTLfppEKRG 119
Cdd:cd17322    49 VSAVSQPPYAKLSDVFGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYNagyTGLNLLLTLILADFSSL---KNRG 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 120 AAMGTVGLAIIFAPAIGPTLAGYVLEHYSWE---TMFYGIIPPTVVVIVCGFIYLKNVSKRS------------------ 178
Cdd:cd17322   126 FASAIPSLPYIITTWIGGNIAQAALPNSNWRwgyGMWAIILPLSSLPLVLCLLYMQRKARKDgeikelknqeteeqtggl 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 179 -------YPKLDMISVALSTIGFGSLLYGFSRAGSA--GWTSAEVLLALGAGTLSLGLF-IWRQLASHNPLLDLRAFKYN 248
Cdd:cd17322   206 sqnlvklFWKLDIFGVILLTAGLGLILVPLTLAGGAksKWKNSSIIAMIVLGGVLLVAFlLWEAKFAKYPFLPFRLLKDR 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 249 MFSLTTVISIAVTIVMYADMILLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFG-AKWLAIIGLLITIST 327
Cdd:cd17322   286 TILAACLIDFFYFFSYYIFSDYLYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRrYKVLVIIGVPLYIVG 365

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1712582547 328 TLSFINLTDSTSYI-YLVFMSTGRQIGMAMFLMPIQTAGLNQLPAKLNAHGTAISNTVKQVAGAIGTS 394
Cdd:cd17322   366 MGLLIRYRGGSGSHgGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAA 433
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-178 5.17e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 48.72  E-value: 5.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLAtlnqtVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAI 80
Cdd:COG2223   216 GTFGSFIG-----FSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLAL 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  81 A-ASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHY-SWETMFYGIIP 158
Cdd:COG2223   291 AlGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAV 370

                         170       180
                  ....*....|....*....|
gi 1712582547 159 PTVVVIVCGFIYLKNVSKRS 178
Cdd:COG2223   371 LALVALVLTLLLYRRPRRAA 390
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-177 5.35e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 48.70  E-value: 5.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMND-FNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAA 79
Cdd:COG0738   215 GGLAIFLYVGAEGAIGDWLPLYLKDvLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLAL 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  80 IAASFPVLLTGRLIQATGAGIIMPLLINVILTLFPpEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPP 159
Cdd:COG0738   295 LAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLG-KRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVC 373

                         170
                  ....*....|....*...
gi 1712582547 160 TVVVIVCGFIYLKNVSKR 177
Cdd:COG0738   374 YLLILLLALALKRKRRKK 391
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 14-341 6.57e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 48.07  E-value: 6.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  14 VMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAASFPVLLTGRLI 93
Cdd:cd17371    17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRAL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  94 QATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLA----IIFAPAIGPTLAGYVLEHYSWETMFY-GIIPPTVVVIVcgf 168
Cdd:cd17371    97 AGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGwavgWLLATLLAALLFPLLPPEIAWRVLFLlGALPALLVLFI--- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 169 iylknvsKRSYPKLDMISVAlstigfgsllygfSRAGSAGWTSAEVLLALGAGTLslglfiwrqlashnplldlrafkyN 248
Cdd:cd17371   174 -------RRFVKEPPQWQAA-------------RAARRHFADRPSLRELFSPPLL------------------------R 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 249 MFSLTTVISIAVTIVMYADMILLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLAIIGLLITISTT 328
Cdd:cd17371   210 TTLLASLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISI 289

                         330
                  ....*....|...
gi 1712582547 329 LSFINLTDSTSYI 341
Cdd:cd17371   290 LLYFFLPLSPTLI 302
emrD PRK11652
multidrug transporter EmrD;
12-149 7.44e-06

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 47.98  E-value: 7.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  12 QTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAASFPVLLTGR 91
Cdd:PRK11652   24 QTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAAS 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1712582547  92 LIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSW 149
Cdd:PRK11652  104 AIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGW 161
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 16-170 1.25e-05

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 47.22  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  16 GVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAASFP-VLLTGRLIQ 94
Cdd:cd17353    23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPlLFLGYGVLG 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1712582547  95 ATGAGIIMPLLINVILTLFpPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFY--GIIpPTVVVIVCGFIY 170
Cdd:cd17353   103 GIGAGIGYITPVSTAVKWF-PDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLilGII-FLIIIVIGAFLI 178
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 68-176 1.28e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 47.21  E-value: 1.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  68 MFIFLTGTIVAAIAASFPVLLTGRLIQatGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHY 147
Cdd:cd17472    69 LLLFIAGSLLAAYATSIYGLILGRALQ--GSGAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHL 146

                          90       100
                  ....*....|....*....|....*....
gi 1712582547 148 SWETMFYGIIPPTVVVIVCGFIYLKNVSK 176
Cdd:cd17472   147 GVSGLFLITAILSLVSLLILLFFVPDPPK 175
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 1-169 5.47e-05

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 45.26  E-value: 5.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMNDFNISAATAQW-LTTGYMLVNGVLIPITA-YLMQRFTTRQLFQTSMFIFLTGTIVA 78
Cdd:cd17315     2 AALGGLLFGYDLGVINGALLYIAKDLGFGLSTSLQgLVVSSLLLGAAIGSLFGgPLADRFGRRKSLLIAAVLYVIGALLS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  79 AIAASFPVLLTGRLIQATGAGI---IMPLLINVILtlfPPEKRGA------AMGTVGLAIIFapaigptLAGYVLEHYS- 148
Cdd:cd17315    82 ALAPNVWVLIVGRFLLGLGVGLasvLVPLYISEIA---PAKIRGAlgtlnqLMITFGILLAY-------LLGLALSLSPp 151

                         170       180
                  ....*....|....*....|...
gi 1712582547 149 --WETMFYGIIPPTVVVIVCGFI 169
Cdd:cd17315   152 gwWRLMFALAAVPALLQLLLMFF 174
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 1-165 7.88e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 44.88  E-value: 7.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMND-FNISAATAQWLTTG----YMLVNGVLIPItayLMQRFTTRQLFQTSMFIFLTGT 75
Cdd:cd17330   179 LLLVYFLIALAFAGLESVFSLFLKDrFGFSPSQIGLLLALvgiaGILAQLLLIPR---LAKRLGERKLLRLGLLLAIIGL 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  76 IVAAIAASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYG 155
Cdd:cd17330   256 LLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLL 335

                         170
                  ....*....|
gi 1712582547 156 IIPPTVVVIV 165
Cdd:cd17330   336 AAGLLLIALF 345
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 2-143 3.57e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 42.55  E-value: 3.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   2 IFGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIA 81
Cdd:cd17477     2 LLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1712582547  82 ASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYV 143
Cdd:cd17477    82 DSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALV 143
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
 13-149 5.42e-04

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 42.18  E-value: 5.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  13 TVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVaAIAASFPVLLTGRL 92
Cdd:cd17339    16 TSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILL-RSLGGIALLFLGTA 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1712582547  93 IQATGAGIIMPLLINVILTLFpPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSW 149
Cdd:cd17339    95 LAGAGIAVGNVLLPSLIKRDF-PRRVGLMTGLYTTSMNLGAALASGLSVPLAQALGG 150
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 24-236 6.14e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 41.79  E-value: 6.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  24 NDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAASFPVLLTGRLIQATGAGIImP 103
Cdd:cd17330    27 NKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNV-S 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 104 LLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPTVVVIVCGFIYLKNVskrSYPKLD 183
Cdd:cd17330   106 VAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPL---RRLLLV 182

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1712582547 184 MISVALSTIGFGSLLYGFSRAgSAGWTSAEV---LLALGAGTLSLGLFIWRQLASH 236
Cdd:cd17330   183 YFLIALAFAGLESVFSLFLKD-RFGFSPSQIgllLALVGIAGILAQLLLIPRLAKR 237
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-157 6.76e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 42.03  E-value: 6.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQR-FTTRQLFQTSMFIFLTGTIVAA 79
Cdd:cd06174   209 LLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLL 288

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1712582547  80 IAASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVL-EHYSWETMFYGII 157
Cdd:cd06174   289 LAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLA 367
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 22-168 6.83e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.77  E-value: 6.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  22 LMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAASFPVLLTGRLIQATGAGII 101
Cdd:cd17324   225 LTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAA 304

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1712582547 102 MPLLINVILTLfPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPTVVVIVCGF 168
Cdd:cd17324   305 HSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 252-408 8.43e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.43  E-value: 8.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 252 LTTVISIAVTIVMYADMILLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLAIIGLLIT-ISTTLS 330
Cdd:cd17316   181 LLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSgILALPL 260

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1712582547 331 FINLTDSTSYIYLVFMSTGRQIGMAMFLMPIQTAGLnqLPAKLNAHGTAISNTVKQVAGAIGTSLLVTIMMSRTATHM 408
Cdd:cd17316   261 FYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAEL--FPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGV 336
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 1-171 9.18e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 41.44  E-value: 9.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTV-MGVAM---PELMNDFNISAATAQWLTTGYMLVNGVLIPITA-YLMQRFTTRQLFQTSMFIFLTGT 75
Cdd:cd17490   196 LLFFSLLAILQQMItFSTTFgftPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGtLFYKKLGERNTIIIGFLLLGAYC 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  76 IVAAIAASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYG 155
Cdd:cd17490   276 FLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFV 355

                         170
                  ....*....|....*.
gi 1712582547 156 IippTVVVIVCGFIYL 171
Cdd:cd17490   356 I---GVIALLAAILSL 368
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 15-156 1.10e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 41.10  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  15 MGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAASFPVLLTGR-LI 93
Cdd:cd17355    22 FGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWgLL 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1712582547  94 QATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGI 156
Cdd:cd17355   102 GGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVL 164
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 29-172 1.24e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.06  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  29 SAATAQWLTTGYMLVNGVLI----PITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAASFPVLLTGRLIQATGAGIIMPL 104
Cdd:cd17329   230 ILGLGESLLGLLLALNALLIvllqFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPA 309

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1712582547 105 LINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIpptVVVIVCGFIYLK 172
Cdd:cd17329   310 VQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILA---ALGLIAAALLLG 374
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 67-174 1.64e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 40.62  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  67 SMFIFLTgtiVAAIAASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEH 146
Cdd:cd17380    75 SLATLLT---PLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEY 151

                          90       100
                  ....*....|....*....|....*...
gi 1712582547 147 YSWETMFYGIIPPTVVVIVCGFIYLKNV 174
Cdd:cd17380   152 YGWPSVFYFFGLLGLLWALVWLIYLPPV 179
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
16-328 3.39e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.84  E-value: 3.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  16 GVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAASFPVLLTGRLIQA 95
Cdd:COG0738    28 GPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLG 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  96 TGAGIIMPLlINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEH---YSWETMFYGI-IPPTVVVIVCGFIYL 171
Cdd:COG0738   108 LGLGLLDVA-ANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILaVLLLLLALLFLRSKL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 172 KNVSKRSYPKLDMISVALSTIGFGSLLYGfsragsagwtsaeVLLALGAGTLSLGLFIWrqlashnplldlrafkynmfs 251
Cdd:COG0738   187 PEIEEEEEEAAGSAASLKSLLKNPRLLLG-------------GLAIFLYVGAEGAIGDW--------------------- 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 252 lttvisiavtivmyadmilLPLYLQSARGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKW-------LAIIGLLIT 324
Cdd:COG0738   233 -------------------LPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRllrlsalLAAVGLLLA 293


                  ....
gi 1712582547 325 ISTT 328
Cdd:COG0738   294 LLAP 297
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 8-171 3.93e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 39.53  E-value: 3.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   8 ATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAASFPVL 87
Cdd:cd17475     8 ASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  88 LTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFygiIPPTVVVIVCG 167
Cdd:cd17475    88 LVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAF---VVAGLVSILAA 164


                  ....
gi 1712582547 168 FIYL 171
Cdd:cd17475   165 VLFW 168
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 5-167 3.94e-03

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 39.32  E-value: 3.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   5 AFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIA-AS 83
Cdd:cd17314    12 SAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVfNS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  84 FPVLLTGRLIQATGAGIIMPLLINVILTLFpPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPTVVV 163
Cdd:cd17314    92 FPLSYACFVFIGAGTGILYGSAVLVTTQYF-PDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIV 170


                  ....
gi 1712582547 164 IVCG 167
Cdd:cd17314   171 LSVV 174
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
1-147 4.53e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.50  E-value: 4.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   1 MIFGAFLATLNQTVMGVAMPELMND-FNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAA 79
Cdd:COG2211   233 LLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF 312

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1712582547  80 IA--ASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEK-------RGAAMGTVGLAIIFAPAIGPTLAGYVLEHY 147
Cdd:COG2211   313 FLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALF 389
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 254-401 4.77e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.11  E-value: 4.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547 254 TVISIAVTIVMYADMILLPLYLQSArGYSAMESGLLLLPGSLVMGLLMPVTGKLFDRFGAKWLAIIGLLITISTTLSFIN 333
Cdd:cd17489     2 LLANFFFFLSFYLLLPVLPLYAHDL-GGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1712582547 334 LTDSTSYIYLVFMstgRQIGMAMFLMPIQTAGLNQLPAKLNAHGTAISNTVKQVAGAIGTSLLVTIMM 401
Cdd:cd17489    81 ATSVALLLVLRLI---HGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ 145
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 49-154 6.54e-03

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 38.79  E-value: 6.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  49 PITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAASFPVLLTGRLIQATGAGIIMpLLINVILTLFPPEKRGAAMGTVGLA 128
Cdd:cd17389    82 PITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVS-LSTAIVADVTSPKKRSKGMALIGVA 160

                          90       100       110
                  ....*....|....*....|....*....|
gi 1712582547 129 I----IFAPAIGptlAGYVLEHYSWETMFY 154
Cdd:cd17389   161 FslgfIIGPMIG---AYFASFTRSLGEVFF 187
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 3-172 8.21e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 38.51  E-value: 8.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547   3 FGAFLATLNQTVMGVAMPELMNDFNISAATAQWLTTGYMLVNGVLIPITAYLMQRFTTRQLFQTSMFIFLTGTIVAAIAA 82
Cdd:TIGR00881   2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  83 SFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVL-EHYSWETMFYGiipPTV 161
Cdd:TIGR00881  82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIaELYSWHWVFIV---PGI 158

                         170
                  ....*....|.
gi 1712582547 162 VVIVCGFIYLK 172
Cdd:TIGR00881 159 IAIIVSLICFL 169
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 53-166 8.34e-03

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 38.37  E-value: 8.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  53 YLMQRFTTRQLFQTSMFI--FLTGTIVAAIAASFPVLLTGRLIQATGAGIIMPLLINVILTLFPPEKRGAAMGTVGLAII 130
Cdd:cd17318    78 YLAEKYGAKRVLGYSILItaLLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQ 157

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1712582547 131 FAPAIGPTLAGYVLEHYSWETMFYgiIPPTVVVIVC 166
Cdd:cd17318   158 FGTVIAMPLSGFLCESLGWPSIFY--IFGGLGLLWC 191
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
18-165 9.26e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 38.36  E-value: 9.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  18 AMPELMNDFNISAATAQWLTTGYMLvngvlipitaylmqRFTTRQLFQTSMF-------IFLTGTIVAAIAASFPVLLTG 90
Cdd:PRK11102   13 ALPVIAADFGVSAGSVQMTLSAYIL--------------GFAIGQLFYGPMAdsfgrkpVILGGTLVFALAAVACALAQT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1712582547  91 -------RLIQATgAGIIMPLLINVIL-TLFPPEKRGAAMGTVGLAIIFAPAIGPTLAGYVLEHYSWETMFYGIIPPTVV 162
Cdd:PRK11102   79 idqliymRFLHGL-AAAAASVVINALMrDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAIL 157


                  ...
gi 1712582547 163 VIV 165
Cdd:PRK11102  158 AAA 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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