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Conserved domains on  [gi|1709624|sp|P51866|]
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RecName: Full=Platelet endothelial cell adhesion molecule; Short=PECAM-1; AltName: CD_antigen=CD31; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 327-404 1.86e-22

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


:

Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 91.69  E-value: 1.86e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1709624    327 KPKLESSATHLDQGEDLNLLCSIPGAPPANFTIQKGGMTVSQTQN-FTKRVSEWDSGLYTCVAGVGRVFKRSNTVQITV 404
Cdd:pfam13895   1 KPVLTPSPTVVTEGEPVTLTCSAPGNPPPSYTWYKDGSAISSSPNfFTLSVSAEDSGTYTCVARNGRGGKVSNPVELTV 79
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 43-119 7.85e-09

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05753:

Pssm-ID: 472250  Cd Length: 83  Bit Score: 53.08  E-value: 7.85e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1709624   43 PHSTVQNGENLTLQClvdvsTTSRVKPLHQVLFYKDDVLLHNvsSRRNTeSYLIPHVRVCDSGRYKCNVILNNKEKT 119
Cdd:cd05753   7 PSAVVFEGEPLTLRC-----HGWKDKKVHKVTYYKDGKALKF--SYENS-NFSIPQATLSDSGSYHCSGTVRIKRRS 75
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 511-591 3.45e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.88  E-value: 3.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709624     511 EVEPGEPIVFYCSVNeGSFPITYKFYKEKESKPFYQDTINATQIMWHKT----TASKEYEGQYYCTASNranlSKHVIQS 586
Cdd:smart00410   5 TVKEGESVTLSCEAS-GSPPPEVTWYKQGGKLLAESGRFSVSRSGSTSTltisNVTPEDSGTYTCAATN----SSGSASS 79


                   ....*.
gi 1709624     587 NT-LTV 591
Cdd:smart00410  80 GTtLTV 85
Ig_C17orf99 super family cl39263
C17orf99 Ig domain; This Ig domain is found in tandem in the uncharacterized human protein ...
 423-480 1.70e-03

C17orf99 Ig domain; This Ig domain is found in tandem in the uncharacterized human protein C17orf99, which is found across mammalian species.


The actual alignment was detected with superfamily member pfam17736:

Pssm-ID: 465476  Cd Length: 95  Bit Score: 38.25  E-value: 1.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1709624    423 KGQTIEVSCQSVNGTAPIFYQL-SNTSKPVANQSVGSNKPAIFRVKPTK-----DVEYCCSADN 480
Cdd:pfam17736  15 SGRRVLISCHASQGSPPITYSLvGSDGIVVAKKIPLHGEPANFSLNITLksspdLLTYQCQAAN 78
 
Name Accession Description Interval E-value
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 327-404 1.86e-22

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 91.69  E-value: 1.86e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1709624    327 KPKLESSATHLDQGEDLNLLCSIPGAPPANFTIQKGGMTVSQTQN-FTKRVSEWDSGLYTCVAGVGRVFKRSNTVQITV 404
Cdd:pfam13895   1 KPVLTPSPTVVTEGEPVTLTCSAPGNPPPSYTWYKDGSAISSSPNfFTLSVSAEDSGTYTCVARNGRGGKVSNPVELTV 79
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 43-119 7.85e-09

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 53.08  E-value: 7.85e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1709624   43 PHSTVQNGENLTLQClvdvsTTSRVKPLHQVLFYKDDVLLHNvsSRRNTeSYLIPHVRVCDSGRYKCNVILNNKEKT 119
Cdd:cd05753   7 PSAVVFEGEPLTLRC-----HGWKDKKVHKVTYYKDGKALKF--SYENS-NFSIPQATLSDSGSYHCSGTVRIKRRS 75
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 511-591 3.45e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.88  E-value: 3.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709624     511 EVEPGEPIVFYCSVNeGSFPITYKFYKEKESKPFYQDTINATQIMWHKT----TASKEYEGQYYCTASNranlSKHVIQS 586
Cdd:smart00410   5 TVKEGESVTLSCEAS-GSPPPEVTWYKQGGKLLAESGRFSVSRSGSTSTltisNVTPEDSGTYTCAATN----SSGSASS 79


                   ....*.
gi 1709624     587 NT-LTV 591
Cdd:smart00410  80 GTtLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 43-121 4.80e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.49  E-value: 4.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709624      43 PHSTVQNGENLTLQCLVDVSTTSRV---KPLHQVLFYKDDVllhNVSSRRNTESYLIPHVRVCDSGRYKCNVILNNKEKT 119
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVtwyKQGGKLLAESGRF---SVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSAS 78


                   ..
gi 1709624     120 TP 121
Cdd:smart00410  79 SG 80
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 340-404 1.51e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.95  E-value: 1.51e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1709624     340 GEDLNLLCSIPGAPPANFT-IQKGGMTVSQTQNFT------------KRVSEWDSGLYTCVAGVGrVFKRSNTVQITV 404
Cdd:smart00410   9 GESVTLSCEASGSPPPEVTwYKQGGKLLAESGRFSvsrsgststltiSNVTPEDSGTYTCAATNS-SGSASSGTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 45-111 3.07e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.86  E-value: 3.07e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1709624     45 STVQNGENLTLQCLVDVSttsrvkPLHQVLFYKDDVLLHNVSSRRNTE-----SYLIPHVRVCDSGRYKCNV 111
Cdd:pfam13927  11 VTVREGETVTLTCEATGS------PPPTITWYKNGEPISSGSTRSRSLsgsnsTLTISNVTRSDAGTYTCVA 76
Ig_C17orf99 pfam17736
C17orf99 Ig domain; This Ig domain is found in tandem in the uncharacterized human protein ...
 423-480 1.70e-03

C17orf99 Ig domain; This Ig domain is found in tandem in the uncharacterized human protein C17orf99, which is found across mammalian species.


Pssm-ID: 465476  Cd Length: 95  Bit Score: 38.25  E-value: 1.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1709624    423 KGQTIEVSCQSVNGTAPIFYQL-SNTSKPVANQSVGSNKPAIFRVKPTK-----DVEYCCSADN 480
Cdd:pfam17736  15 SGRRVLISCHASQGSPPITYSLvGSDGIVVAKKIPLHGEPANFSLNITLksspdLLTYQCQAAN 78
IgI_Twitchin_like cd20949
C-terminal immunoglobulin-like domain of the myosin-associated giant protein kinase Twitchin, ...
 332-388 4.07e-03

C-terminal immunoglobulin-like domain of the myosin-associated giant protein kinase Twitchin, and similar domains; member of the I-set IgSF domains; The members here are composed of the C-terminal immunoglobulin-like domain of the myosin-associated giant protein kinase Twitchin and similar proteins, including Caenorhabditis elegans and Aplysia californica Twitchin, Drosophila melanogaster Projectin, and similar proteins. These are very large muscle proteins containing multiple immunoglobulin (Ig)-like and fibronectin type III (FN3) domains and a single kinase domain near the C-terminus. In humans these proteins are called Titin. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The Ig-like domain of the Twitchin is a member of the I-set IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins (titin, telokin, and twitchin), the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D.


Pssm-ID: 409541 [Multi-domain]  Cd Length: 89  Bit Score: 36.93  E-value: 4.07e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1709624  332 SSATHLDQGEDLNLLCSIPGAPPANFTIQKGGMTVSQTQNFTK------------RVSEWDSGLYTCVA 388
Cdd:cd20949   6 AYVTTVKEGQSATILCEVKGEPQPNVTWHFNGQPISASVADMSkyriladgllinKVTQDDTGEYTCRA 74
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 511-575 8.53e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.00  E-value: 8.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1709624    511 EVEPGEPIVFYCSVNEGSFPiTYKFYK---EKESKPFYQDTINATQIMWHKTTASKEYEGQYYCTASN 575
Cdd:pfam13927  12 TVREGETVTLTCEATGSPPP-TITWYKngePISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCVASN 78
 
Name Accession Description Interval E-value
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 327-404 1.86e-22

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 91.69  E-value: 1.86e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1709624    327 KPKLESSATHLDQGEDLNLLCSIPGAPPANFTIQKGGMTVSQTQN-FTKRVSEWDSGLYTCVAGVGRVFKRSNTVQITV 404
Cdd:pfam13895   1 KPVLTPSPTVVTEGEPVTLTCSAPGNPPPSYTWYKDGSAISSSPNfFTLSVSAEDSGTYTCVARNGRGGKVSNPVELTV 79
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 43-119 7.85e-09

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 53.08  E-value: 7.85e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1709624   43 PHSTVQNGENLTLQClvdvsTTSRVKPLHQVLFYKDDVLLHNvsSRRNTeSYLIPHVRVCDSGRYKCNVILNNKEKT 119
Cdd:cd05753   7 PSAVVFEGEPLTLRC-----HGWKDKKVHKVTYYKDGKALKF--SYENS-NFSIPQATLSDSGSYHCSGTVRIKRRS 75
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 511-591 3.45e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.88  E-value: 3.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709624     511 EVEPGEPIVFYCSVNeGSFPITYKFYKEKESKPFYQDTINATQIMWHKT----TASKEYEGQYYCTASNranlSKHVIQS 586
Cdd:smart00410   5 TVKEGESVTLSCEAS-GSPPPEVTWYKQGGKLLAESGRFSVSRSGSTSTltisNVTPEDSGTYTCAATN----SSGSASS 79


                   ....*.
gi 1709624     587 NT-LTV 591
Cdd:smart00410  80 GTtLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 327-388 3.95e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 42.55  E-value: 3.95e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1709624    327 KPKL--ESSATHLDQGEDLNLLCSIPGAPPANFTIQKGG-----------MTVSQTQNFT-KRVSEWDSGLYTCVA 388
Cdd:pfam13927   1 KPVItvSPSSVTVREGETVTLTCEATGSPPPTITWYKNGepissgstrsrSLSGSNSTLTiSNVTRSDAGTYTCVA 76
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 43-121 4.80e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.49  E-value: 4.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709624      43 PHSTVQNGENLTLQCLVDVSTTSRV---KPLHQVLFYKDDVllhNVSSRRNTESYLIPHVRVCDSGRYKCNVILNNKEKT 119
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVtwyKQGGKLLAESGRF---SVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSAS 78


                   ..
gi 1709624     120 TP 121
Cdd:smart00410  79 SG 80
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 340-404 1.51e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.95  E-value: 1.51e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1709624     340 GEDLNLLCSIPGAPPANFT-IQKGGMTVSQTQNFT------------KRVSEWDSGLYTCVAGVGrVFKRSNTVQITV 404
Cdd:smart00410   9 GESVTLSCEASGSPPPEVTwYKQGGKLLAESGRFSvsrsgststltiSNVTPEDSGTYTCAATNS-SGSASSGTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 45-111 3.07e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.86  E-value: 3.07e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1709624     45 STVQNGENLTLQCLVDVSttsrvkPLHQVLFYKDDVLLHNVSSRRNTE-----SYLIPHVRVCDSGRYKCNV 111
Cdd:pfam13927  11 VTVREGETVTLTCEATGS------PPPTITWYKNGEPISSGSTRSRSLsgsnsTLTISNVTRSDAGTYTCVA 76
Ig_C17orf99 pfam17736
C17orf99 Ig domain; This Ig domain is found in tandem in the uncharacterized human protein ...
 423-480 1.70e-03

C17orf99 Ig domain; This Ig domain is found in tandem in the uncharacterized human protein C17orf99, which is found across mammalian species.


Pssm-ID: 465476  Cd Length: 95  Bit Score: 38.25  E-value: 1.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1709624    423 KGQTIEVSCQSVNGTAPIFYQL-SNTSKPVANQSVGSNKPAIFRVKPTK-----DVEYCCSADN 480
Cdd:pfam17736  15 SGRRVLISCHASQGSPPITYSLvGSDGIVVAKKIPLHGEPANFSLNITLksspdLLTYQCQAAN 78
IgV_1_Necl_like cd05717
First (N-terminal) immunoglobulin (Ig)-like domain of the nectin-like molecules; member of the ...
 44-109 3.03e-03

First (N-terminal) immunoglobulin (Ig)-like domain of the nectin-like molecules; member of the V-set of Ig superfamily (IgSF) domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 (CADM3)), Necl-2 (CADM1), Necl-3 (CADM2), and similar proteins. At least five nectin-like molecules have been identified (Necl-1 to Necl-5). They all have an extracellular region containing three Ig-like domains, a transmembrane region, and a cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1, Necl-2, and Necl-3 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue, and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues and is a putative tumour suppressor gene which is downregulated in aggressive neuroblastoma. Necl-3 accumulates in central and peripheral nervous system tissue and has been shown to selectively interact with oligodendrocytes. This group also contains Class-I MHC-restricted T-cell-associated molecule (CRTAM), whose expression pattern is consistent with its expression in Class-I MHC-restricted T-cells.


Pssm-ID: 409382  Cd Length: 94  Bit Score: 37.49  E-value: 3.03e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1709624   44 HSTVQNGENLTLQCLVDVSTTSRVK---PLHQVLFYKDDVLLHN-----VSSRRNTESYLIPHVRVCDSGRYKC 109
Cdd:cd05717   5 DVTVVEGETLTLKCQVSLRDDSSLQwlnPNGQTIYFNDKRALRDsryqlLNHSASELSISVSNVTLSDEGVYTC 78
IgI_Twitchin_like cd20949
C-terminal immunoglobulin-like domain of the myosin-associated giant protein kinase Twitchin, ...
 332-388 4.07e-03

C-terminal immunoglobulin-like domain of the myosin-associated giant protein kinase Twitchin, and similar domains; member of the I-set IgSF domains; The members here are composed of the C-terminal immunoglobulin-like domain of the myosin-associated giant protein kinase Twitchin and similar proteins, including Caenorhabditis elegans and Aplysia californica Twitchin, Drosophila melanogaster Projectin, and similar proteins. These are very large muscle proteins containing multiple immunoglobulin (Ig)-like and fibronectin type III (FN3) domains and a single kinase domain near the C-terminus. In humans these proteins are called Titin. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The Ig-like domain of the Twitchin is a member of the I-set IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins (titin, telokin, and twitchin), the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D.


Pssm-ID: 409541 [Multi-domain]  Cd Length: 89  Bit Score: 36.93  E-value: 4.07e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1709624  332 SSATHLDQGEDLNLLCSIPGAPPANFTIQKGGMTVSQTQNFTK------------RVSEWDSGLYTCVA 388
Cdd:cd20949   6 AYVTTVKEGQSATILCEVKGEPQPNVTWHFNGQPISASVADMSkyriladgllinKVTQDDTGEYTCRA 74
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 343-388 4.92e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 36.15  E-value: 4.92e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 1709624  343 LNLLCSIPGAPPANFTIQKGGMTVSQTQNFT------------KRVSEWDSGLYTCVA 388
Cdd:cd00096   1 VTLTCSASGNPPPTITWYKNGKPLPPSSRDSrrselgngtltiSNVTLEDSGTYTCVA 58
IgC2_CEACAM5-like cd20948
Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell ...
 331-388 6.87e-03

Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), also known as CD66e (Cluster of Differentiation 66e), is a cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Diseases associated with CEACAM5 include lung cancer and rectum cancer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409540  Cd Length: 76  Bit Score: 35.94  E-value: 6.87e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1709624  331 ESSATHLDQGEDLNLLCSIPGAPPANF--TIQKGGMTVSQTQNFTKRVSEwDSGLYTCVA 388
Cdd:cd20948   1 SPSDTYYLSGENLNLSCHAASNPPAQYswTINGTFQTSSQELFLPAITEN-NEGTYTCSA 59
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 511-575 8.53e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.00  E-value: 8.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1709624    511 EVEPGEPIVFYCSVNEGSFPiTYKFYK---EKESKPFYQDTINATQIMWHKTTASKEYEGQYYCTASN 575
Cdd:pfam13927  12 TVREGETVTLTCEATGSPPP-TITWYKngePISSGSTRSRSLSGSNSTLTISNVTRSDAGTYTCVASN 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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