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Conserved domains on  [gi|1707808713|gb|QDL94569|]
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GntR family transcriptional regulator (plasmid) [Paroceanicella profunda]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
36-224 2.13e-32

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 118.10  E-value: 2.13e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707808713  36 PQAERAYRRIEAAIVTCALRPGSFQRIQDLAALAGTGRTPVHQAVSRLAADTLLDVLPRQGLLVAPVELGRCRVLLGLRR 115
Cdd:COG1802    11 SLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVRA 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707808713 116 EVERFAIGLAAARATEGQRSHMRHLAGALRAAGDTLDLADFNAFDTRIDAVVLEACGEPFLENTLRPLHSVFRRvgwIWH 195
Cdd:COG1802    91 ALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRR---YRR 167

                         170       180
                  ....*....|....*....|....*....
gi 1707808713 196 GLATPGPDPAASVSAHLDVLDALADGRGE 224
Cdd:COG1802   168 LSLRSPGRLEESLAEHRAILDALEAGDAE 196
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
36-224 2.13e-32

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 118.10  E-value: 2.13e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707808713  36 PQAERAYRRIEAAIVTCALRPGSFQRIQDLAALAGTGRTPVHQAVSRLAADTLLDVLPRQGLLVAPVELGRCRVLLGLRR 115
Cdd:COG1802    11 SLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVRA 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707808713 116 EVERFAIGLAAARATEGQRSHMRHLAGALRAAGDTLDLADFNAFDTRIDAVVLEACGEPFLENTLRPLHSVFRRvgwIWH 195
Cdd:COG1802    91 ALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRR---YRR 167

                         170       180
                  ....*....|....*....|....*....
gi 1707808713 196 GLATPGPDPAASVSAHLDVLDALADGRGE 224
Cdd:COG1802   168 LSLRSPGRLEESLAEHRAILDALEAGDAE 196
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 113-224 1.31e-11

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 60.08  E-value: 1.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707808713 113 LRREVERFAIGLAAARATEGQRSHMRHLAGALRAAGDTLDLADFNAFDTRIDAVVLEACGEPFLENTLRPLHsvfRRVGW 192
Cdd:pfam07729   5 LRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLW---DRLRR 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1707808713 193 IWHGLATPGPDPAASVSAHLDVLDALADGRGE 224
Cdd:pfam07729  82 LRRLLLSSPGRLRASLEEHRAILDAIRARDPE 113
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 110-224 3.94e-09

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 53.52  E-value: 3.94e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707808713  110 LLGLRREVERFAIGLAAARATEGQRSHMRHLAGALRAAGDTLD-LADFNAFDTRIDAVVLEACGEPFLENTLRPLHSVFR 188
Cdd:smart00895   2 LYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGDdLEEFAELDREFHRALAEAAGNPVLLELLESLRARLR 81

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1707808713  189 RVgwiwhgLATPGPDPAASVSAHLDVLDALADGRGE 224
Cdd:smart00895  82 RL------RRLSLEAARRALDEHRAILDAIRARDAE 111
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 36-194 8.08e-07

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 48.74  E-value: 8.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707808713  36 PQAERAYRRIEAAIVTCALRPGSFQRIQDLAALAGTGRTPVHQAVSRLAADTLLDVLPRQGLLVAPVELGRCRVLLGLRR 115
Cdd:PRK11534    7 ITALDGYRWLKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707808713 116 EVERFAIGLAAARATEG------QRSHMRHLAGALRAAGDTLDLAD--FNAFDTRIDAvvleACGEPFLENTLRPLHSVF 187
Cdd:PRK11534   87 NMEAMLVSLAIARGGDEweadvlAKAHLLSKLEACDASEKMLDEWDlrHQAFHTAIVA----GCGSHYLLQMRERLFDLA 162


                  ....*..
gi 1707808713 188 RRVGWIW 194
Cdd:PRK11534  163 ARYRFIW 169
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 36-100 5.59e-06

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 42.82  E-value: 5.59e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1707808713  36 PQAERAYRRIEAAIVTCALRPGsfQRI---QDLAALAGTGRTPVHQAVSRLAADTLLDVLPRQGLLVA 100
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPG--DRLpseRELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
36-224 2.13e-32

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 118.10  E-value: 2.13e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707808713  36 PQAERAYRRIEAAIVTCALRPGSFQRIQDLAALAGTGRTPVHQAVSRLAADTLLDVLPRQGLLVAPVELGRCRVLLGLRR 115
Cdd:COG1802    11 SLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVRA 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707808713 116 EVERFAIGLAAARATEGQRSHMRHLAGALRAAGDTLDLADFNAFDTRIDAVVLEACGEPFLENTLRPLHSVFRRvgwIWH 195
Cdd:COG1802    91 ALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRR---YRR 167

                         170       180
                  ....*....|....*....|....*....
gi 1707808713 196 GLATPGPDPAASVSAHLDVLDALADGRGE 224
Cdd:COG1802   168 LSLRSPGRLEESLAEHRAILDALEAGDAE 196
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
38-224 1.91e-17

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 78.82  E-value: 1.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707808713  38 AERAYRRIEAAIVTCALRPGSfqRI---QDLAALAGTGRTPVHQAVSRLAADTLLDVLPRQGLLVAPVELGR-------- 106
Cdd:COG2186     9 AEQVAEQLRELILSGELKPGD--RLpseRELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWAlldplall 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707808713 107 -------CRVLLGLRREVERFAIGLAAARATEGQRSHMRHLAGALRAAGDtlDLADFNAFDTRIDAVVLEACGEPFLENT 179
Cdd:COG2186    87 lalddasLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAAD--DGEAFAEADLAFHRAIAEASGNPLLALL 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1707808713 180 LRPLHSVFRRVgwIWHGLATPGpDPAASVSAHLDVLDALADGRGE 224
Cdd:COG2186   165 LESLRELLRRS--VRLTLRSPE-ARERSLAEHRAILDAIRAGDPE 206
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 113-224 1.31e-11

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 60.08  E-value: 1.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707808713 113 LRREVERFAIGLAAARATEGQRSHMRHLAGALRAAGDTLDLADFNAFDTRIDAVVLEACGEPFLENTLRPLHsvfRRVGW 192
Cdd:pfam07729   5 LRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLW---DRLRR 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1707808713 193 IWHGLATPGPDPAASVSAHLDVLDALADGRGE 224
Cdd:pfam07729  82 LRRLLLSSPGRLRASLEEHRAILDAIRARDPE 113
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 110-224 3.94e-09

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 53.52  E-value: 3.94e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707808713  110 LLGLRREVERFAIGLAAARATEGQRSHMRHLAGALRAAGDTLD-LADFNAFDTRIDAVVLEACGEPFLENTLRPLHSVFR 188
Cdd:smart00895   2 LYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGDdLEEFAELDREFHRALAEAAGNPVLLELLESLRARLR 81

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1707808713  189 RVgwiwhgLATPGPDPAASVSAHLDVLDALADGRGE 224
Cdd:smart00895  82 RL------RRLSLEAARRALDEHRAILDAIRARDAE 111
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 36-194 8.08e-07

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 48.74  E-value: 8.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707808713  36 PQAERAYRRIEAAIVTCALRPGSFQRIQDLAALAGTGRTPVHQAVSRLAADTLLDVLPRQGLLVAPVELGRCRVLLGLRR 115
Cdd:PRK11534    7 ITALDGYRWLKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707808713 116 EVERFAIGLAAARATEG------QRSHMRHLAGALRAAGDTLDLAD--FNAFDTRIDAvvleACGEPFLENTLRPLHSVF 187
Cdd:PRK11534   87 NMEAMLVSLAIARGGDEweadvlAKAHLLSKLEACDASEKMLDEWDlrHQAFHTAIVA----GCGSHYLLQMRERLFDLA 162


                  ....*..
gi 1707808713 188 RRVGWIW 194
Cdd:PRK11534  163 ARYRFIW 169
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 38-99 1.02e-06

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 44.91  E-value: 1.02e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1707808713  38 AERAYRRIEAAIVTCALRPGS-FQRIQDLAALAGTGRTPVHQAVSRLAADTLLDVLPRQGLLV 99
Cdd:pfam00392   2 YEQVYARLREDILSGRLRPGDkLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 36-100 5.59e-06

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 42.82  E-value: 5.59e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1707808713  36 PQAERAYRRIEAAIVTCALRPGsfQRI---QDLAALAGTGRTPVHQAVSRLAADTLLDVLPRQGLLVA 100
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPG--DRLpseRELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
41-99 5.81e-06

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 42.95  E-value: 5.81e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707808713   41 AYRRIEAAIVTCALRPGS-FQRIQDLAALAGTGRTPVHQAVSRLAADTLLDVLPRQGLLV 99
Cdd:smart00345   1 VAERLREDIVSGELRPGDkLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK11414 PRK11414
GntR family transcriptional regulator;
53-155 6.63e-06

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 46.02  E-value: 6.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707808713  53 ALRPGSFQRIQDLAALAGTGRTPVHQAVSRLAADTLLDVLPRQGLLVAPVELGRCRVLLGLRREVERFAIGLAAARATEG 132
Cdd:PRK11414   28 ALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVSKRQLDEINRIRYELELMAVALAVENLTPQ 107

                          90       100
                  ....*....|....*....|...
gi 1707808713 133 QRSHMRHLAGALRAAGDTLDLAD 155
Cdd:PRK11414  108 DLAELQELLEKLQQAQEKGDMEQ 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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