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Conserved domains on  [gi|1707435590|ref|NP_001358593|]
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ribosome biogenesis protein WDR12 isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
26-272 4.20e-42

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.91  E-value: 4.20e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590  26 DQTILLWewNVERNKVkaLHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTvptdeedemeestnrprkkqkteql 105
Cdd:COG2319   141 DGTVRLW--DLATGKL--LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL------------------------- 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 106 gLTRTPIVTLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWDVESGSLKSTLTG-NKVFNCISYSPLCKRLASGSTDRHI 183
Cdd:COG2319   192 -ATGKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTV 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 184 RLWDPRTkdGSLVSLsLTSHTGWVTSVKWSPThEQQLISGSLDNIVKLWDTRSCKaPLYDLAAHEDKVLSVDWTDTG-LL 262
Cdd:COG2319   271 RLWDLAT--GELLRT-LTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFSPDGkTL 345

                         250
                  ....*....|
gi 1707435590 263 LSGGADNKLY 272
Cdd:COG2319   346 ASGSDDGTVR 355
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
26-272 4.20e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.91  E-value: 4.20e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590  26 DQTILLWewNVERNKVkaLHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTvptdeedemeestnrprkkqkteql 105
Cdd:COG2319   141 DGTVRLW--DLATGKL--LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL------------------------- 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 106 gLTRTPIVTLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWDVESGSLKSTLTG-NKVFNCISYSPLCKRLASGSTDRHI 183
Cdd:COG2319   192 -ATGKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTV 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 184 RLWDPRTkdGSLVSLsLTSHTGWVTSVKWSPThEQQLISGSLDNIVKLWDTRSCKaPLYDLAAHEDKVLSVDWTDTG-LL 262
Cdd:COG2319   271 RLWDLAT--GELLRT-LTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFSPDGkTL 345

                         250
                  ....*....|
gi 1707435590 263 LSGGADNKLY 272
Cdd:COG2319   346 ASGSDDGTVR 355
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 26-275 6.83e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 145.56  E-value: 6.83e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590  26 DQTILLWewNVERNKVkaLHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVptdeedemeestnrprkkqkteql 105
Cdd:cd00200    30 DGTIKVW--DLETGEL--LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE------------------------ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 106 glTRTPIVTLSGHMEAVSSVLWSDAEEI-CSASWDHTIRVWDVESGSLKSTLTGNKVF-NCISYSPLCKRLASGSTDRHI 183
Cdd:cd00200    82 --TGECVRTLTGHTSYVSSVAFSPDGRIlSSSSRDKTIKVWDVETGKCLTTLRGHTDWvNSVAFSPDGTFVASSSQDGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 184 RLWDPRTkdGSLVSlSLTSHTGWVTSVKWSPThEQQLISGSLDNIVKLWDTRScKAPLYDLAAHEDKVLSVDWTDTGLLL 263
Cdd:cd00200   160 KLWDLRT--GKCVA-TLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLST-GKCLGTLRGHENGVNSVAFSPDGYLL 234

                         250
                  ....*....|...
gi 1707435590 264 -SGGADNKLYSYR 275
Cdd:cd00200   235 aSGSEDGTIRVWD 247
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 54-283 7.56e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 62.41  E-value: 7.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590  54 VDSIAVDGSGTKFCSGSWDKMLKIWstvptdeedEMEESTNRPRKkqkteqlglTRTPIVTLSGHMEaVSSVLWSD--AE 131
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIF---------ECESIIKDGRD---------IHYPVVELASRSK-LSGICWNSyiKS 546

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 132 EICSASWDHTIRVWDVESGSLKSTLTGNK--VFNCISYSPLCKRLASGSTDRHIRLWDPRTKdgslVSLSLTSHTGWVTS 209
Cdd:PLN00181  547 QVASSNFEGVVQVWDVARSQLVTEMKEHEkrVWSIDYSSADPTLLASGSDDGSVKLWSINQG----VSIGTIKTKANICC 622

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1707435590 210 VKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSPTTSHV 283
Cdd:PLN00181  623 VQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGI 696
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 199-233 2.43e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 2.43e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1707435590  199 SLTSHTGWVTSVKWSPTHeQQLISGSLDNIVKLWD 233
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
199-233 1.31e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.31e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1707435590 199 SLTSHTGWVTSVKWSPTHeQQLISGSLDNIVKLWD 233
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
26-272 4.20e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.91  E-value: 4.20e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590  26 DQTILLWewNVERNKVkaLHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTvptdeedemeestnrprkkqkteql 105
Cdd:COG2319   141 DGTVRLW--DLATGKL--LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL------------------------- 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 106 gLTRTPIVTLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWDVESGSLKSTLTG-NKVFNCISYSPLCKRLASGSTDRHI 183
Cdd:COG2319   192 -ATGKLLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTV 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 184 RLWDPRTkdGSLVSLsLTSHTGWVTSVKWSPThEQQLISGSLDNIVKLWDTRSCKaPLYDLAAHEDKVLSVDWTDTG-LL 262
Cdd:COG2319   271 RLWDLAT--GELLRT-LTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFSPDGkTL 345

                         250
                  ....*....|
gi 1707435590 263 LSGGADNKLY 272
Cdd:COG2319   346 ASGSDDGTVR 355
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 26-275 6.83e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 145.56  E-value: 6.83e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590  26 DQTILLWewNVERNKVkaLHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVptdeedemeestnrprkkqkteql 105
Cdd:cd00200    30 DGTIKVW--DLETGEL--LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE------------------------ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 106 glTRTPIVTLSGHMEAVSSVLWSDAEEI-CSASWDHTIRVWDVESGSLKSTLTGNKVF-NCISYSPLCKRLASGSTDRHI 183
Cdd:cd00200    82 --TGECVRTLTGHTSYVSSVAFSPDGRIlSSSSRDKTIKVWDVETGKCLTTLRGHTDWvNSVAFSPDGTFVASSSQDGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 184 RLWDPRTkdGSLVSlSLTSHTGWVTSVKWSPThEQQLISGSLDNIVKLWDTRScKAPLYDLAAHEDKVLSVDWTDTGLLL 263
Cdd:cd00200   160 KLWDLRT--GKCVA-TLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLST-GKCLGTLRGHENGVNSVAFSPDGYLL 234

                         250
                  ....*....|...
gi 1707435590 264 -SGGADNKLYSYR 275
Cdd:cd00200   235 aSGSEDGTIRVWD 247
WD40 COG2319
WD40 repeat [General function prediction only];
26-271 2.82e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.98  E-value: 2.82e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590  26 DQTILLWEWNvernKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVptdeedemeestnrprkkqkteql 105
Cdd:COG2319   183 DGTVRLWDLA----TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA------------------------ 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 106 glTRTPIVTLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWDVESGSLKSTLTGNK-VFNCISYSPLCKRLASGSTDRHI 183
Cdd:COG2319   235 --TGKLLRTLTGHSGSVRSVAFSpDGRLLASGSADGTVRLWDLATGELLRTLTGHSgGVNSVAFSPDGKLLASGSDDGTV 312

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 184 RLWDPRTkdGSLVSlSLTSHTGWVTSVKWSPThEQQLISGSLDNIVKLWDTRScKAPLYDLAAHEDKVLSVDWTDTG-LL 262
Cdd:COG2319   313 RLWDLAT--GKLLR-TLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLWDLAT-GELLRTLTGHTGAVTSVAFSPDGrTL 387


                  ....*....
gi 1707435590 263 LSGGADNKL 271
Cdd:COG2319   388 ASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-271 7.82e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.16  E-value: 7.82e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590  25 MDQTILLWEWnverNKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTvptdeedemeestnrprkkqkteq 104
Cdd:cd00200    71 SDKTIRLWDL----ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV------------------------ 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 105 lgLTRTPIVTLSGHMEAVSSVLWSDAEE-ICSASWDHTIRVWDVESGSLKSTLTGNKVF-NCISYSPLCKRLASGSTDRH 182
Cdd:cd00200   123 --ETGKCLTTLRGHTDWVNSVAFSPDGTfVASSSQDGTIKLWDLRTGKCVATLTGHTGEvNSVAFSPDGEKLLSSSSDGT 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 183 IRLWDPRTKDgslVSLSLTSHTGWVTSVKWSPtHEQQLISGSLDNIVKLWDTRSCKaPLYDLAAHEDKVLSVDWTDTG-L 261
Cdd:cd00200   201 IKLWDLSTGK---CLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGE-CVQTLSGHTNSVTSLAWSPDGkR 275

                         250
                  ....*....|
gi 1707435590 262 LLSGGADNKL 271
Cdd:cd00200   276 LASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
26-236 1.09e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.65  E-value: 1.09e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590  26 DQTILLWewNVERNKVKALHccRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVptdeedemeestnrprkkqkteql 105
Cdd:COG2319   225 DGTVRLW--DLATGKLLRTL--TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA------------------------ 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 106 glTRTPIVTLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWDVESGSLKSTLTG-NKVFNCISYSPLCKRLASGSTDRHI 183
Cdd:COG2319   277 --TGELLRTLTGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGKTLASGSDDGTV 354

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1707435590 184 RLWDPRTKdgsLVSLSLTSHTGWVTSVKWSPtHEQQLISGSLDNIVKLWDTRS 236
Cdd:COG2319   355 RLWDLATG---ELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
48-271 2.97e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.50  E-value: 2.97e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590  48 RGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTvptdeedemeestnrprkkqkteqlgLTRTPIVTLSGHMEAVSSVLW 127
Cdd:COG2319    75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDL--------------------------ATGLLLRTLTGHTGAVRSVAF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 128 S-DAEEICSASWDHTIRVWDVESGSLKSTLTG-NKVFNCISYSPLCKRLASGSTDRHIRLWDPRTkdGSLVsLSLTSHTG 205
Cdd:COG2319   129 SpDGKTLASGSADGTVRLWDLATGKLLRTLTGhSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT--GKLL-RTLTGHTG 205

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1707435590 206 WVTSVKWSPtHEQQLISGSLDNIVKLWDTRSCKaPLYDLAAHEDKVLSVDWTDTG-LLLSGGADNKL 271
Cdd:COG2319   206 AVRSVAFSP-DGKLLASGSADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFSPDGrLLASGSADGTV 270
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 26-233 3.63e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 3.63e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590  26 DQTILLWEWNvernKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVptdeedemeestnrprkkqkteql 105
Cdd:cd00200   114 DKTIKVWDVE----TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR------------------------ 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 106 glTRTPIVTLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWDVESGSLKSTLTG-NKVFNCISYSPLCKRLASGSTDRHI 183
Cdd:cd00200   166 --TGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTI 243

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1707435590 184 RLWDPRTKDgslVSLSLTSHTGWVTSVKWSPThEQQLISGSLDNIVKLWD 233
Cdd:cd00200   244 RVWDLRTGE---CVQTLSGHTNSVTSLAWSPD-GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
107-271 5.11e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 5.11e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 107 LTRTPIVTLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWDVESGSLKSTLTG-NKVFNCISYSPLCKRLASGSTDRHIR 184
Cdd:COG2319    66 AAGALLATLLGHTAAVLSVAFSpDGRLLASASADGTVRLWDLATGLLLRTLTGhTGAVRSVAFSPDGKTLASGSADGTVR 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 185 LWDPRTkdGSLVSlSLTSHTGWVTSVKWSPThEQQLISGSLDNIVKLWDTRSCKaPLYDLAAHEDKVLSVDWTDTG-LLL 263
Cdd:COG2319   146 LWDLAT--GKLLR-TLTGHSGAVTSVAFSPD-GKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFSPDGkLLA 220


                  ....*...
gi 1707435590 264 SGGADNKL 271
Cdd:COG2319   221 SGSADGTV 228
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 111-270 7.01e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.27  E-value: 7.01e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 111 PIVTLSGHMEAVSSVLWSDAEE-ICSASWDHTIRVWDVESGSLKSTLTGNKVF-NCISYSPLCKRLASGSTDRHIRLWDp 188
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPvRDVAASADGTYLASGSSDKTIRLWD- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 189 rTKDGSLVSlSLTSHTGWVTSVKWSPTHeQQLISGSLDNIVKLWDTRSCKaPLYDLAAHEDKVLSVDWTDTGLLLSGGAD 268
Cdd:cd00200    80 -LETGECVR-TLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGK-CLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155


                  ..
gi 1707435590 269 NK 270
Cdd:cd00200   156 DG 157
WD40 COG2319
WD40 repeat [General function prediction only];
95-271 6.97e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 6.97e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590  95 RPRKKQKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVESGSLKSTLTGNKVF-NCISYSPLCKR 173
Cdd:COG2319    13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAvLSVAFSPDGRL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 174 LASGSTDRHIRLWDPRTkdgSLVSLSLTSHTGWVTSVKWSPTHeQQLISGSLDNIVKLWDTRSCKaPLYDLAAHEDKVLS 253
Cdd:COG2319    93 LASASADGTVRLWDLAT---GLLLRTLTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGK-LLRTLTGHSGAVTS 167

                         170
                  ....*....|....*....
gi 1707435590 254 VDWTDTG-LLLSGGADNKL 271
Cdd:COG2319   168 VAFSPDGkLLASGSDDGTV 186
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 54-283 7.56e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 62.41  E-value: 7.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590  54 VDSIAVDGSGTKFCSGSWDKMLKIWstvptdeedEMEESTNRPRKkqkteqlglTRTPIVTLSGHMEaVSSVLWSD--AE 131
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIF---------ECESIIKDGRD---------IHYPVVELASRSK-LSGICWNSyiKS 546

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 132 EICSASWDHTIRVWDVESGSLKSTLTGNK--VFNCISYSPLCKRLASGSTDRHIRLWDPRTKdgslVSLSLTSHTGWVTS 209
Cdd:PLN00181  547 QVASSNFEGVVQVWDVARSQLVTEMKEHEkrVWSIDYSSADPTLLASGSDDGSVKLWSINQG----VSIGTIKTKANICC 622

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1707435590 210 VKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSPTTSHV 283
Cdd:PLN00181  623 VQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGI 696
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 199-233 2.43e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 2.43e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1707435590  199 SLTSHTGWVTSVKWSPTHeQQLISGSLDNIVKLWD 233
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 174-270 3.90e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 3.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 174 LASGSTDRHIRLWDPRTKDGSLVSLS-----LTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAhe 248
Cdd:PTZ00420   90 LASGSEDLTIRVWEIPHNDESVKEIKdpqciLKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMP-- 167

                          90       100
                  ....*....|....*....|..
gi 1707435590 249 DKVLSVDWTDTGLLLSGGADNK 270
Cdd:PTZ00420  168 KKLSSLKWNIKGNLLSGTCVGK 189
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-79 5.57e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 5.57e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1707435590  25 MDQTILLWEWNvernKVKALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWS 79
Cdd:cd00200   239 EDGTIRVWDLR----TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
199-233 1.31e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.31e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1707435590 199 SLTSHTGWVTSVKWSPTHeQQLISGSLDNIVKLWD 233
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 108-146 1.68e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 1.68e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1707435590  108 TRTPIVTLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWD 146
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 106-266 1.98e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.65  E-value: 1.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 106 GLTRT---PIVTLSGHMEAVSSVLW--SDAEEICSASWDHTIRVWDVESGSLKSTLTG-NKVFNCISYSPLCKRLASGST 179
Cdd:PTZ00421  109 GLTQNisdPIVHLQGHTKKVGIVSFhpSAMNVLASAGADMVVNVWDVERGKAVEVIKChSDQITSLEWNLDGSLLCTTSK 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 180 DRHIRLWDPRtkDGSLVSLSLTSHTGWVTSVKWSptHEQQLI-----SGSLDNIVKLWDTRSCKAPLY--DLAAHEDKVL 252
Cdd:PTZ00421  189 DKKLNIIDPR--DGTIVSSVEAHASAKSQRCLWA--KRKDLIitlgcSKSQQRQIMLWDTRKMASPYStvDLDQSSALFI 264

                         170
                  ....*....|....
gi 1707435590 253 SVDWTDTGLLLSGG 266
Cdd:PTZ00421  265 PFFDEDTNLLYIGS 278
WD40 pfam00400
WD domain, G-beta repeat;
109-146 8.90e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 8.90e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1707435590 109 RTPIVTLSGHMEAVSSVLWS-DAEEICSASWDHTIRVWD 146
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSpDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 68-277 1.36e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.01  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590  68 SGSWDKMLKIWStVPTDEEDEMEestnrprkkqkteqlglTRTPIVTLSGHMEAVSSVLWSDAEE--ICSASWDHTIRVW 145
Cdd:PTZ00420   92 SGSEDLTIRVWE-IPHNDESVKE-----------------IKDPQCILKGHKKKISIIDWNPMNYyiMCSSGFDSFVNIW 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 146 DVESGSLKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDgslVSLSLTSHTG-------WVTSVKWSPTHeq 218
Cdd:PTZ00420  154 DIENEKRAFQINMPKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQE---IASSFHIHDGgkntkniWIDGLGGDDNY-- 228

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1707435590 219 QLISG-SLDNI--VKLWDTRSCKAPLYD---------LAAHEDKvlsvdwtDTGLL-LSGGADNKLYSYRYS 277
Cdd:PTZ00420  229 ILSTGfSKNNMreMKLWDLKNTTSALVTmsidnasapLIPHYDE-------STGLIyLIGKGDGNCRYYQHS 293
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 42-79 1.94e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 1.94e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1707435590   42 KALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWS 79
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 149-187 4.62e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 4.62e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1707435590  149 SGSLKSTLTG-NKVFNCISYSPLCKRLASGSTDRHIRLWD 187
Cdd:smart00320   1 SGELLKTLKGhTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
42-79 5.23e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 5.23e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1707435590  42 KALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWS 79
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 129-238 2.05e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.49  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1707435590 129 DAEEICSASWDHTIRVWDVESGSLKST-------LTG-NKVFNCISYSPLCKR-LASGSTDRHIRLWDPRTkdGSLVSlS 199
Cdd:PTZ00421   87 DPQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGhTKKVGIVSFHPSAMNvLASAGADMVVNVWDVER--GKAVE-V 163

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1707435590 200 LTSHTGWVTSVKWSpTHEQQLISGSLDNIVKLWDTRSCK 238
Cdd:PTZ00421  164 IKCHSDQITSLEWN-LDGSLLCTTSKDKKLNIIDPRDGT 201
WD40 pfam00400
WD domain, G-beta repeat;
150-187 3.14e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 3.14e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1707435590 150 GSLKSTLTGNKVF-NCISYSPLCKRLASGSTDRHIRLWD 187
Cdd:pfam00400   1 GKLLKTLEGHTGSvTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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