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Conserved domains on  [gi|1706522494|gb|QDM67885|]
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GtrOC26 [Acinetobacter baumannii]

Protein Classification

glycosyltransferase family protein( domain architecture ID 27718)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 4-224 3.93e-27

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd06433:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 202  Bit Score: 105.71  E-value: 3.93e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   4 SVIVPSYNHAQYLEDRIESILKQSYSQFEVILLDDLSSDHSAEILEKYknHPKVSHCIINKQNsGstfcQ---WNKGIHL 80
Cdd:cd06433     1 SIITPTYNQAETLEETIDSVLSQTYPNIEYIVIDGGSTDGTVDIIKKY--EDKITYWISEPDK-G----IydaMNKGIAL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494  81 AKG-YLIWIaESDDVADSQFLEKLVPRFEKNPKLVLAYSQSYRMNAHGEVTGTWKDFTDHVNPELFGkdfempgleyier 159
Cdd:cd06433    74 ATGdIIGFL-NSDDTLLPGALLAVVAAFAEHPEVDVVYGDVLLVDENGRVIGRRRPPPFLDKFLLYG------------- 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1706522494 160 flsaqNTIPNaSGVIFKKQSYFDVGGANPKLRFIGDWEIWAKIVSQGDIFF-SHECLNYFRYHDTS 224
Cdd:cd06433   140 -----MPICH-QATFFRRSLFEKYGGFDESYRIAADYDLLLRLLLAGKIFKyLPEVLAAFRLGGVS 199
 
Name Accession Description Interval E-value
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 4-224 3.93e-27

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 105.71  E-value: 3.93e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   4 SVIVPSYNHAQYLEDRIESILKQSYSQFEVILLDDLSSDHSAEILEKYknHPKVSHCIINKQNsGstfcQ---WNKGIHL 80
Cdd:cd06433     1 SIITPTYNQAETLEETIDSVLSQTYPNIEYIVIDGGSTDGTVDIIKKY--EDKITYWISEPDK-G----IydaMNKGIAL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494  81 AKG-YLIWIaESDDVADSQFLEKLVPRFEKNPKLVLAYSQSYRMNAHGEVTGTWKDFTDHVNPELFGkdfempgleyier 159
Cdd:cd06433    74 ATGdIIGFL-NSDDTLLPGALLAVVAAFAEHPEVDVVYGDVLLVDENGRVIGRRRPPPFLDKFLLYG------------- 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1706522494 160 flsaqNTIPNaSGVIFKKQSYFDVGGANPKLRFIGDWEIWAKIVSQGDIFF-SHECLNYFRYHDTS 224
Cdd:cd06433   140 -----MPICH-QATFFRRSLFEKYGGFDESYRIAADYDLLLRLLLAGKIFKyLPEVLAAFRLGGVS 199
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-122 3.37e-26

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 103.24  E-value: 3.37e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   1 MFVSVIVPSYNHAQYLEDRIESILKQSYSQFEVILLDDLSSDHSAEILEKY-KNHPKVsHCIINKQNSGSTFcQWNKGIH 79
Cdd:COG0463     2 PLVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELaAKDPRI-RVIRLERNRGKGA-ARNAGLA 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1706522494  80 LAKGYLIWIAESDDVADSQFLEKLVPRFEKNPKLVLAYSQSYR 122
Cdd:COG0463    80 AARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSRLIR 122
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 4-175 2.62e-25

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 99.78  E-value: 2.62e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   4 SVIVPSYNHAQYLEDRIESILKQSYSQFEVILLDDLSSDHSAEILEKYKNHPKVSHCIINKQNSG-STfcQWNKGIHLAK 82
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPENRGkAG--ARNAGLRAAT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494  83 GYLIWIAESDDVADSQFLEKLVPRFEKNPKLVlaysqsyrmnahgeVTGTWKDFTDHVNPELFGKDFEMPGLEYIERFLS 162
Cdd:pfam00535  79 GDYIAFLDADDEVPPDWLEKLVEALEEDGADV--------------VVGSRYVIFGETGEYRRASRITLSRLPFFLGLRL 144

                         170
                  ....*....|...
gi 1706522494 163 AQNTIPNASGVIF 175
Cdd:pfam00535 145 LGLNLPFLIGGFA 157
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 3-104 2.23e-14

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 72.77  E-value: 2.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   3 VSVIVPSYNHAQYLEDRIESILKQSYSQFEVILLDDLSSDHSAEILEKY-KNHPKVShcIINKQNSGSTfCQWNKGIHLA 81
Cdd:PRK10073    8 LSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYaENYPHVR--LLHQANAGVS-VARNTGLAVA 84

                          90       100
                  ....*....|....*....|...
gi 1706522494  82 KGYLIWIAESDDVADSQFLEKLV 104
Cdd:PRK10073   85 TGKYVAFPDADDVVYPTMYETLM 107
 
Name Accession Description Interval E-value
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 4-224 3.93e-27

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 105.71  E-value: 3.93e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   4 SVIVPSYNHAQYLEDRIESILKQSYSQFEVILLDDLSSDHSAEILEKYknHPKVSHCIINKQNsGstfcQ---WNKGIHL 80
Cdd:cd06433     1 SIITPTYNQAETLEETIDSVLSQTYPNIEYIVIDGGSTDGTVDIIKKY--EDKITYWISEPDK-G----IydaMNKGIAL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494  81 AKG-YLIWIaESDDVADSQFLEKLVPRFEKNPKLVLAYSQSYRMNAHGEVTGTWKDFTDHVNPELFGkdfempgleyier 159
Cdd:cd06433    74 ATGdIIGFL-NSDDTLLPGALLAVVAAFAEHPEVDVVYGDVLLVDENGRVIGRRRPPPFLDKFLLYG------------- 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1706522494 160 flsaqNTIPNaSGVIFKKQSYFDVGGANPKLRFIGDWEIWAKIVSQGDIFF-SHECLNYFRYHDTS 224
Cdd:cd06433   140 -----MPICH-QATFFRRSLFEKYGGFDESYRIAADYDLLLRLLLAGKIFKyLPEVLAAFRLGGVS 199
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-122 3.37e-26

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 103.24  E-value: 3.37e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   1 MFVSVIVPSYNHAQYLEDRIESILKQSYSQFEVILLDDLSSDHSAEILEKY-KNHPKVsHCIINKQNSGSTFcQWNKGIH 79
Cdd:COG0463     2 PLVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELaAKDPRI-RVIRLERNRGKGA-ARNAGLA 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1706522494  80 LAKGYLIWIAESDDVADSQFLEKLVPRFEKNPKLVLAYSQSYR 122
Cdd:COG0463    80 AARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSRLIR 122
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 5-120 2.59e-25

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 99.50  E-value: 2.59e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   5 VIVPSYNHAQYLEDRIESILKQSYSQFEVILLDDLSSDHSAEILEKYKNHPKVSHCIINKQNSGSTFcQWNKGIHLAKGY 84
Cdd:cd00761     1 VIIPAYNEEPYLERCLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYAKKDPRVIRVINEENQGLAA-ARNAGLKAARGE 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1706522494  85 LIWIAESDDVADSQFLEKLVPRFEKNPKLVLAYSQS 120
Cdd:cd00761    80 YILFLDADDLLLPDWLERLVAELLADPEADAVGGPG 115
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 4-175 2.62e-25

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 99.78  E-value: 2.62e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   4 SVIVPSYNHAQYLEDRIESILKQSYSQFEVILLDDLSSDHSAEILEKYKNHPKVSHCIINKQNSG-STfcQWNKGIHLAK 82
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPENRGkAG--ARNAGLRAAT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494  83 GYLIWIAESDDVADSQFLEKLVPRFEKNPKLVlaysqsyrmnahgeVTGTWKDFTDHVNPELFGKDFEMPGLEYIERFLS 162
Cdd:pfam00535  79 GDYIAFLDADDEVPPDWLEKLVEALEEDGADV--------------VVGSRYVIFGETGEYRRASRITLSRLPFFLGLRL 144

                         170
                  ....*....|...
gi 1706522494 163 AQNTIPNASGVIF 175
Cdd:pfam00535 145 LGLNLPFLIGGFA 157
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 4-226 1.53e-20

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 88.07  E-value: 1.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   4 SVIVPSYNHAQYLEDRIESILKQSYSQFEVILLDDLSSDHSAEILEKY-KNHPKVSHCIINKQNSGST--FcqwNKGIHL 80
Cdd:cd04196     1 AVLMATYNGEKYLREQLDSILAQTYKNDELIISDDGSTDGTVEIIKEYiDKDPFIIILIRNGKNLGVArnF---ESLLQA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494  81 AKGYLIWIAESDDVADSQFLEKLVPRFEKNPKLVLAYSQSYRMNAHGEVTGTWKDFTDHVNPelfGKDFEmpgleyierF 160
Cdd:cd04196    78 ADGDYVFFCDQDDIWLPDKLERLLKAFLKDDKPLLVYSDLELVDENGNPIGESFFEYQKIKP---GTSFN---------N 145

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1706522494 161 LSAQNTIPNASGVIfkkqsyfdvggaNPKLR-----------FIGDWEIWAKIVSQGDIFFSHECLNYFRYHDTSVI 226
Cdd:cd04196   146 LLFQNVVTGCTMAF------------NRELLelalpfpdadvIMHDWWLALLASAFGKVVFLDEPLILYRQHGNNVV 210
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-104 6.72e-19

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 83.50  E-value: 6.72e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   1 MFVSVIVPSYNHAQYLEDRIESILKQSYSQFEVILLDDLSSDHSAEILEKYKnHPKVsHCIINKQNSGstFC-QWNKGIH 79
Cdd:COG1216     3 PKVSVVIPTYNRPELLRRCLESLLAQTYPPFEVIVVDNGSTDGTAELLAALA-FPRV-RVIRNPENLG--FAaARNLGLR 78

                          90       100
                  ....*....|....*....|....*
gi 1706522494  80 LAKGYLIWIAESDDVADSQFLEKLV 104
Cdd:COG1216    79 AAGGDYLLFLDDDTVVEPDWLERLL 103
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 1-108 7.68e-19

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 85.56  E-value: 7.68e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   1 MFVSVIVPSYNHAQYLEDRIESILKQSY--SQFEVILLDDLSSDHSAEILEKYKNHPKVSHCIINKQNSGSTFCQwNKGI 78
Cdd:COG1215    29 PRVSVIIPAYNEEAVIEETLRSLLAQDYpkEKLEVIVVDDGSTDETAEIARELAAEYPRVRVIERPENGGKAAAL-NAGL 107

                          90       100       110
                  ....*....|....*....|....*....|
gi 1706522494  79 HLAKGYLIWIAESDDVADSQFLEKLVPRFE 108
Cdd:COG1215   108 KAARGDIVVFLDADTVLDPDWLRRLVAAFA 137
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 5-114 1.45e-16

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 76.50  E-value: 1.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   5 VIVPSYNHAQYLEDRIESILKQSYSQFEVILLDDLSSDHSAEILEKY-KNHPKVSHCIINKQNSGSTFCQwNKGIHLAKG 83
Cdd:cd06423     1 IIVPAYNEEAVIERTIESLLALDYPKLEVIVVDDGSTDDTLEILEELaALYIRRVLVVRDKENGGKAGAL-NAGLRHAKG 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1706522494  84 YLIWIAESDDVADSQFLEKLVPRFEKNPKLV 114
Cdd:cd06423    80 DIVVVLDADTILEPDALKRLVVPFFADPKVG 110
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 2-104 1.61e-14

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 72.26  E-value: 1.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   2 FVSVIVPSYNHAQYLEDRIESILKQSYSQ--FEVILLDDLSSDHSAEILEKYKN-HPKVShCIINKQNSGStfCQWNKGI 78
Cdd:cd02525     1 FVSIIIPVRNEEKYIEELLESLLNQSYPKdlIEIIVVDGGSTDGTREIVQEYAAkDPRIR-LIDNPKRIQS--AGLNIGI 77

                          90       100
                  ....*....|....*....|....*.
gi 1706522494  79 HLAKGYLIWIAESDDVADSQFLEKLV 104
Cdd:cd02525    78 RNSRGDIIIRVDAHAVYPKDYILELV 103
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 3-104 2.23e-14

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 72.77  E-value: 2.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   3 VSVIVPSYNHAQYLEDRIESILKQSYSQFEVILLDDLSSDHSAEILEKY-KNHPKVShcIINKQNSGSTfCQWNKGIHLA 81
Cdd:PRK10073    8 LSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYaENYPHVR--LLHQANAGVS-VARNTGLAVA 84

                          90       100
                  ....*....|....*....|...
gi 1706522494  82 KGYLIWIAESDDVADSQFLEKLV 104
Cdd:PRK10073   85 TGKYVAFPDADDVVYPTMYETLM 107
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 3-211 2.39e-14

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 71.25  E-value: 2.39e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   3 VSVIVPSYNHAQYLEDRIESILKQSYSQFEVILLDDLSSDHSAEIL-EKYKNHPKVS-HCIINKQNSGSTFCQW--NKGI 78
Cdd:pfam13641   4 VSVVVPAFNEDSVLGRVLEAILAQPYPPVEVVVVVNPSDAETLDVAeEIAARFPDVRlRVIRNARLLGPTGKSRglNHGF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494  79 HLAKGYLIWIAESDDVADSQFLEKLVPRFeKNPKLVLAYSQSYRMNAhgevtGTWKDFTDhvNPELFGKDFEMPGLEYIE 158
Cdd:pfam13641  84 RAVKSDLVVLHDDDSVLHPGTLKKYVQYF-DSPKVGAVGTPVFSLNR-----STMLSALG--ALEFALRHLRMMSLRLAL 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1706522494 159 RFLsaqntIPNASGVIFKKQSYFDVGGANPKLRFIGDWEIWAKIVSQG-DIFFS 211
Cdd:pfam13641 156 GVL-----PLSGAGSAIRREVLKELGLFDPFFLLGDDKSLGRRLRRHGwRVAYA 204
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 5-112 2.82e-13

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 66.81  E-value: 2.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   5 VIVPSYNHAQYLEDRIESILKQSYSQFEVILLDDLSSDHSAEILEKYknHPKVShCIINKQNSGstF---CqwNKGIHLA 81
Cdd:cd04186     1 IIIVNYNSLEYLKACLDSLLAQTYPDFEVIVVDNASTDGSVELLREL--FPEVR-LIRNGENLG--FgagN--NQGIREA 73

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1706522494  82 KGYLIWIAESDDVADSQFLEKLVPRFEKNPK 112
Cdd:cd04186    74 KGDYVLLLNPDTVVEPGALLELLDAAEQDPD 104
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 3-134 1.36e-11

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 63.76  E-value: 1.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   3 VSVIVPSYNHAQYLEDRIESILKQSYS--QFEVILLDDLSSDHSAEILEKYKnhPKVSHCIINKQNSGSTFCQwNKGIHL 80
Cdd:cd06439    31 VTIIIPAYNEEAVIEAKLENLLALDYPrdRLEIIVVSDGSTDGTAEIAREYA--DKGVKLLRFPERRGKAAAL-NRALAL 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1706522494  81 AKGYLIWIAESDDVADSQFLEKLVPRFEkNPKlVLAYSQSYRMNAHGEVTGT----WK 134
Cdd:cd06439   108 ATGEIVVFTDANALLDPDALRLLVRHFA-DPS-VGAVSGELVIVDGGGSGSGeglyWK 163
Glyco_tranf_2_2 pfam10111
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 4-202 4.44e-11

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 313356 [Multi-domain]  Cd Length: 276  Bit Score: 62.68  E-value: 4.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   4 SVIVPSYNHAQ--YLEDRIESILKQSYSQFEVILLDDLSSDHSAEILEKYKNHpkvSHCIINKQNSGSTFCQW---NKGI 78
Cdd:pfam10111   1 SVVIPVYNGEKthWIQERILNQTFQYDPEFELIIINDGSTDKTLEEVSSIKDH---NLQVYYPNAPDTTYSLAasrNRGT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494  79 HLAKGYLIWIAESDDVADSQFLEKLvprfeknpkLVLAYSQSYRMNAHGEVTGTWKDFTDHVNPELFGKDFEMPGLEYIE 158
Cdd:pfam10111  78 SHAIGEYISFIDGDCLWSPDKFEKQ---------LKIATSLALQENIQAAVVLPVTDLNDESSNFLRRGGDLTASGDVLR 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1706522494 159 RFLSAQNTI-----PNASGVIFKKQSYFDVGGANPKLRFIG--DWEIWAKI 202
Cdd:pfam10111 149 DLLVFYSPLaiffaPNSSNALINRQAFIEVGGFDESFRGHGaeDFDIFLRL 199
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 3-145 4.63e-11

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 61.45  E-value: 4.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   3 VSVIVPSYNHAQ-YLEDRIESILKQSYSQFEVILLDDLSSD-HSAEILEKYKNHPKVSHCIINKQN---SGSTfcqwNKG 77
Cdd:cd04184     3 ISIVMPVYNTPEkYLREAIESVRAQTYPNWELCIADDASTDpEVKRVLKKYAAQDPRIKVVFREENggiSAAT----NSA 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494  78 IHLAKGYLIWIAESDDVADSQFLEKLVPRFEKNPKLVLAYSQSYRMNAHGEVTGTW--KDFtdhvNPELF 145
Cdd:cd04184    79 LELATGEFVALLDHDDELAPHALYEVVKALNEHPDADLIYSDEDKIDEGGKRSEPFfkPDW----SPDLL 144
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 4-206 2.94e-09

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 56.17  E-value: 2.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   4 SVIVPSYNH--AQYLEDRIESILKQSYSQFEVILLDD-LSSDHSAEILEKYK-NHP-KVshcIINKQNSGstfcqwnKGI 78
Cdd:cd04195     1 SVLMSVYIKekPEFLREALESILKQTLPPDEVVLVKDgPVTQSLNEVLEEFKrKLPlKV---VPLEKNRG-------LGK 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494  79 HLAKGYLI----WIA--ESDDVADSQFLEKLVPRFEKNPKLVLAYSQSYRMNAHGevtgtwkdfTDHVNPELfgkdfeMP 152
Cdd:cd04195    71 ALNEGLKHctydWVArmDTDDISLPDRFEKQLDFIEKNPEIDIVGGGVLEFDSDG---------NDIGKRRL------PT 135

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1706522494 153 GLEYIERFlsAQNTIP-NASGVIFKKQSYFDVGGANPKLRFiGDWEIWAKIVSQG 206
Cdd:cd04195   136 SHDDILKF--ARRRSPfNHPTVMFRKSKVLAVGGYQDLPLV-EDYALWARMLANG 187
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 5-134 3.22e-09

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 55.66  E-value: 3.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   5 VIVPSYNHAQYLE---DRIESILKQSYsQFEVILLDDLSSDHSAEILEKYKNHPKVSHCIINKQNSGstfcqwnK----- 76
Cdd:cd04179     1 VVIPAYNEEENIPelvERLLAVLEEGY-DYEIIVVDDGSTDGTAEIARELAARVPRVRVIRLSRNFG-------Kgaavr 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1706522494  77 -GIHLAKG-YLIWIAE--SDDVAD-SQFLEKLVprfEKNPKLVLAysqsYRMNAHGEVTGTWK 134
Cdd:cd04179    73 aGFKAARGdIVVTMDAdlQHPPEDiPKLLEKLL---EGGADVVIG----SRFVRGGGAGMPLL 128
GT_2_like_b cd04185
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 5-127 1.11e-08

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133028 [Multi-domain]  Cd Length: 202  Bit Score: 54.56  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   5 VIVPSYNHAQYLEDRIESILKQSYSQFEVILLDDLSSDHSAEILEKYKNHPKVSHcIINKQNSGST--FcqwNKGIHLA- 81
Cdd:cd04185     1 AVVVTYNRLDLLKECLDALLAQTRPPDHIIVIDNASTDGTAEWLTSLGDLDNIVY-LRLPENLGGAggF---YEGVRRAy 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1706522494  82 -KGY-LIWIAESDDVADSQFLEKLVPRFEKNPKLVLaysQSYRMNAHG 127
Cdd:cd04185    77 eLGYdWIWLMDDDAIPDPDALEKLLAYADKDNPQFL---APLVLDPDG 121
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 5-117 1.33e-08

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 54.60  E-value: 1.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   5 VIVPSYNHAQYLEDRIESILKQSY--SQFEVILLDDLSSDHSAEILEKYKNHPKVSHCIIN---KQNSGSTFcQWNKGIH 79
Cdd:cd04192     1 VVIAARNEAENLPRLLQSLSALDYpkEKFEVILVDDHSTDGTVQILEFAAAKPNFQLKILNnsrVSISGKKN-ALTTAIK 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1706522494  80 LAKGYLIWIAESDDVADSQFLEKLV-PRFEKNPKLVLAY 117
Cdd:cd04192    80 AAKGDWIVTTDADCVVPSNWLLTFVaFIQKEQIGLVAGP 118
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 5-83 7.26e-08

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 51.71  E-value: 7.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   5 VIVPSYNHAQYLE---DRIESILKQSYSQFEVILLDDLSSDHSAEILEKY-KNHPKVsHCIINKQNSG---STFCqwnkG 77
Cdd:cd04187     1 IVVPVYNEEENLPelyERLKAVLESLGYDYEIIFVDDGSTDRTLEILRELaARDPRV-KVIRLSRNFGqqaALLA----G 75


                  ....*.
gi 1706522494  78 IHLAKG 83
Cdd:cd04187    76 LDHARG 81
beta3GnTL1_like cd06913
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ...
 5-98 9.96e-08

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.


Pssm-ID: 133063 [Multi-domain]  Cd Length: 219  Bit Score: 52.07  E-value: 9.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   5 VIVPSYNHAQYLEDRIESILKQSYSQ-FEVILLDDLSSDHSAEILEKYKNHPKVS--HCIINKQNSGSTF-CQW--NKGI 78
Cdd:cd06913     1 IILPVHNGEQWLDECLESVLQQDFEGtLELSVFNDASTDKSAEIIEKWRKKLEDSgvIVLVGSHNSPSPKgVGYakNQAI 80

                          90       100
                  ....*....|....*....|
gi 1706522494  79 HLAKGYLIWIAESDDVADSQ 98
Cdd:cd06913    81 AQSSGRYLCFLDSDDVMMPQ 100
PRK10018 PRK10018
colanic acid biosynthesis glycosyltransferase WcaA;
2-93 1.01e-07

colanic acid biosynthesis glycosyltransferase WcaA;


Pssm-ID: 182197 [Multi-domain]  Cd Length: 279  Bit Score: 52.69  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   2 FVSVIVPSYNHAQYLEDRIESILKQSYSQFEVILLDDLSSdhSAEILEKYK---NHPKVSHcIINKQNSGSTFCQwNKGI 78
Cdd:PRK10018    6 LISIYMPTWNRQQLAIRAIKSVLRQDYSNWEMIIVDDCST--SWEQLQQYVtalNDPRITY-IHNDINSGACAVR-NQAI 81

                          90
                  ....*....|....*
gi 1706522494  79 HLAKGYLIWIAESDD 93
Cdd:PRK10018   82 MLAQGEYITGIDDDD 96
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 5-68 5.19e-07

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 49.49  E-value: 5.19e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1706522494   5 VIVPSYNHaqylEDRIESIL--------KQSYSQFEVILLDDLSSDHSAEILEKY-KNHPKVSHCIINKQNSG 68
Cdd:cd04188     1 VVIPAYNE----EKRLPPTLeeaveyleERPSFSYEIIVVDDGSKDGTAEVARKLaRKNPALIRVLTLPKNRG 69
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 5-88 3.13e-06

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 46.80  E-value: 3.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   5 VIVPSYNHAQYLEDRIESILKQSYSQFEVILLDDLSSDHSAEILEKYKNHP--KVSHciINKQNSGSTFCQ-WNKGIHLA 81
Cdd:cd06420     1 LIITTYNRPEALELVLKSVLNQSILPFEVIIADDGSTEETKELIEEFKSQFpiPIKH--VWQEDEGFRKAKiRNKAIAAA 78


                  ....*...
gi 1706522494  82 KG-YLIWI 88
Cdd:cd06420    79 KGdYLIFI 86
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 1-121 5.94e-06

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 47.45  E-value: 5.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   1 MFVSVIVPSYN-----------HAQYLEDRIESILKQSYsqfEVILLDDLSSDHSAEILEKY---KNHPKVSHCIIN-KQ 65
Cdd:PTZ00260   70 VDLSIVIPAYNeedrlpkmlkeTIKYLESRSRKDPKFKY---EIIIVNDGSKDKTLKVAKDFwrqNINPNIDIRLLSlLR 146

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1706522494  66 NSGSTFCQwNKGIHLAKGYLIWIAESD---DVADSQFLEKLVPRFEKNPKLVLAYSQSY 121
Cdd:PTZ00260  147 NKGKGGAV-RIGMLASRGKYILMVDADgatDIDDFDKLEDIMLKIEQNGLGIVFGSRNH 204
PRK10714 PRK10714
undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional
 3-61 1.84e-05

undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional


Pssm-ID: 182669 [Multi-domain]  Cd Length: 325  Bit Score: 45.88  E-value: 1.84e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1706522494   3 VSVIVPSYNHAQYLEDRIESIL---KQSYSQFEVILLDDLSSDHSAEILEKYKNHPKvSHCI 61
Cdd:PRK10714    8 VSVVIPVYNEQESLPELIRRTTaacESLGKEYEILLIDDGSSDNSAEMLVEAAQAPD-SHIV 68
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 5-107 8.41e-04

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 40.21  E-value: 8.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   5 VIVPSYNHAQYLEDRIESILKQSYS-QFEVILLDDLSSDHSAEILEKY-KNHPKVsHCIINKQNSG-STFCQWnkGIHLA 81
Cdd:cd06442     1 IIIPTYNERENIPELIERLDAALKGiDYEIIVVDDNSPDGTAEIVRELaKEYPRV-RLIVRPGKRGlGSAYIE--GFKAA 77

                          90       100
                  ....*....|....*....|....*..
gi 1706522494  82 KG-YLIWIaesDdvADSQFLEKLVPRF 107
Cdd:cd06442    78 RGdVIVVM---D--ADLSHPPEYIPEL 99
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 3-50 1.11e-03

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 39.86  E-value: 1.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1706522494   3 VSVIVPSYNHAQYLEDRIESILKQSYSQFEVILLDDLSSDHSAEILEK 50
Cdd:cd02522     1 LSIIIPTLNEAENLPRLLASLRRLNPLPLEIIVVDGGSTDGTVAIARS 48
CESA_CaSu_A2 cd06437
Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit ...
 2-126 2.07e-03

Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Cellulose synthase (CESA) catalyzes the polymerization reaction of cellulose using UDP-glucose as the substrate. Cellulose is an aggregate of unbranched polymers of beta-1,4-linked glucose residues, which is an abundant polysaccharide produced by plants and in varying degrees by several other organisms including algae, bacteria, fungi, and even some animals. Genomes from higher plants harbor multiple CESA genes. There are ten in Arabidopsis. At least three different CESA proteins are required to form a functional complex. In Arabidopsis, CESA1, 3 and 6 and CESA4, 7 and 8, are required for cellulose biosynthesis during primary and secondary cell wall formation. CESA2 is very closely related to CESA6 and is viewed as a prime substitute for CESA6. They functionally compensate each other. The cesa2 and cesa6 double mutant plants were significantly smaller, while the single mutant plants were almost normal.


Pssm-ID: 133059 [Multi-domain]  Cd Length: 232  Bit Score: 39.22  E-value: 2.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1706522494   2 FVSVIVPSYNHAQYLEDRIESILKQSY--SQFEVILLDDlSSDHSAEILEKYKNHPK-----VSHcIINKQNSGSTFCQW 74
Cdd:cd06437     2 MVTVQLPVFNEKYVVERLIEAACALDYpkDRLEIQVLDD-STDETVRLAREIVEEYAaqgvnIKH-VRRADRTGYKAGAL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1706522494  75 NKGIHLAKGYLIWIAESDDVADSQFLEKLVPRFeKNPKLVL----------AYS-----QSYRMNAH 126
Cdd:cd06437    80 AEGMKVAKGEYVAIFDADFVPPPDFLQKTPPYF-ADPKLGFvqtrwghinaNYSlltrvQAMSLDYH 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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