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Conserved domains on  [gi|17063327|gb|AAL35002|]
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engrailed, partial [Melanoplus sp. MFW-2001]

Protein Classification

homeobox domain-containing protein( domain architecture ID 21)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

CATH:  1.10.10.60
Gene Ontology:  GO:0003677
PubMed:  26464018|1357790
SCOP:  4000291

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain super family cl47488
Homeodomain;
2-45 7.96e-11

Homeodomain;


The actual alignment was detected with superfamily member pfam00046:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 50.19  E-value: 7.96e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 17063327    2 KRPRTAFSGEQLARLKHEFTENRYLTERRRQELARELGLNEAQI 45
Cdd:pfam00046  1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQV 44
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
2-45 7.96e-11

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 50.19  E-value: 7.96e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 17063327    2 KRPRTAFSGEQLARLKHEFTENRYLTERRRQELARELGLNEAQI 45
Cdd:pfam00046  1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQV 44
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 2-45 7.42e-10

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 48.02  E-value: 7.42e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 17063327     2 KRPRTAFSGEQLARLKHEFTENRYLTERRRQELARELGLNEAQI 45
Cdd:smart00389  2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQV 45
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 2-45 5.37e-09

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 45.70  E-value: 5.37e-09
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....
gi 17063327  2 KRPRTAFSGEQLARLKHEFTENRYLTERRRQELARELGLNEAQI 45
Cdd:cd00086  1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQV 44
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
2-45 7.96e-11

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 50.19  E-value: 7.96e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 17063327    2 KRPRTAFSGEQLARLKHEFTENRYLTERRRQELARELGLNEAQI 45
Cdd:pfam00046  1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQV 44
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 2-45 7.42e-10

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 48.02  E-value: 7.42e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 17063327     2 KRPRTAFSGEQLARLKHEFTENRYLTERRRQELARELGLNEAQI 45
Cdd:smart00389  2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQV 45
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 2-45 5.37e-09

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 45.70  E-value: 5.37e-09
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....
gi 17063327  2 KRPRTAFSGEQLARLKHEFTENRYLTERRRQELARELGLNEAQI 45
Cdd:cd00086  1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQV 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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