NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1704621086|gb|QDM04117|]
View 

glycosyltransferase family 4 protein [Escherichia coli]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 11-339 1.49e-18

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member cd03820:

Pssm-ID: 471961 [Multi-domain]  Cd Length: 351  Bit Score: 85.37  E-value: 1.49e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086  11 SISNHGGV-RILLQIANSIANKGGRTKIICPKGTYD-TRYNISDKVEIIEVGPAISNKICRWF-FFTILFPF--YVKNND 85
Cdd:cd03820     8 SISNAGGAeRVAINLANHLAKKGYDVTIISLDSAEKpPFYELDDNIKIKNLGDRKYSHFKLLLkYFKKVRRLrkYLKNNK 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086  86 tvfANFFVTFYASLLSRILFKKIKIVYFIQD-IEYEFFGGLIKKIAKKLCEYSYAYK-----KAEIIAANIYLYERLLVK 159
Cdd:cd03820    88 ---PDVVISFRTSLLTFLALIGLKSKLIVWEhNNYEAYNKGLRRLLLRRLLYKRADKivvltEADKLKKYKQPNSNVVVI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 160 NDAIKLFNVWI-----DEKFITTASVETHRQYDL---IYFLRQDPRK----RI----DRfEEMLpylyENNIsilcvtQS 223
Cdd:cd03820   165 PNPLSFPSEEPstnlkSKRILAVGRLTYQKGFDLlieAWALIAKKHPdwklRIygdgPE-REEL----EKLI------DK 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 224 LDLADRyssqlpVFIPENDQELISLIDKCKIYLLTSSQEGFSLPPLECMARGVIPVVFEC-GGPEIYIEDGLNGFIVNT- 301
Cdd:cd03820   234 LGLEDR------VKLLGPTKNIAEEYANSSIFVLSSRYEGFPMVLLEAMAYGLPIISFDCpTGPSEIIEDGENGLLVPNg 307

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1704621086 302 -IDEASETILKLVKSYDSLIEIKTKAVGTARKisFSEEV 339
Cdd:cd03820   308 dVDALAEALLRLMEDEELRKKMGKNARKNAER--FSIEK 344
 
Name Accession Description Interval E-value
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 11-339 1.49e-18

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 85.37  E-value: 1.49e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086  11 SISNHGGV-RILLQIANSIANKGGRTKIICPKGTYD-TRYNISDKVEIIEVGPAISNKICRWF-FFTILFPF--YVKNND 85
Cdd:cd03820     8 SISNAGGAeRVAINLANHLAKKGYDVTIISLDSAEKpPFYELDDNIKIKNLGDRKYSHFKLLLkYFKKVRRLrkYLKNNK 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086  86 tvfANFFVTFYASLLSRILFKKIKIVYFIQD-IEYEFFGGLIKKIAKKLCEYSYAYK-----KAEIIAANIYLYERLLVK 159
Cdd:cd03820    88 ---PDVVISFRTSLLTFLALIGLKSKLIVWEhNNYEAYNKGLRRLLLRRLLYKRADKivvltEADKLKKYKQPNSNVVVI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 160 NDAIKLFNVWI-----DEKFITTASVETHRQYDL---IYFLRQDPRK----RI----DRfEEMLpylyENNIsilcvtQS 223
Cdd:cd03820   165 PNPLSFPSEEPstnlkSKRILAVGRLTYQKGFDLlieAWALIAKKHPdwklRIygdgPE-REEL----EKLI------DK 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 224 LDLADRyssqlpVFIPENDQELISLIDKCKIYLLTSSQEGFSLPPLECMARGVIPVVFEC-GGPEIYIEDGLNGFIVNT- 301
Cdd:cd03820   234 LGLEDR------VKLLGPTKNIAEEYANSSIFVLSSRYEGFPMVLLEAMAYGLPIISFDCpTGPSEIIEDGENGLLVPNg 307

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1704621086 302 -IDEASETILKLVKSYDSLIEIKTKAVGTARKisFSEEV 339
Cdd:cd03820   308 dVDALAEALLRLMEDEELRKKMGKNARKNAER--FSIEK 344
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 237-349 3.36e-13

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 65.40  E-value: 3.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 237 FIPENDQELI--SLIDKCKIYLLTSSQEGFSLPPLECMARGVIPVVFECGGPEIYIEDGLNGFIV--NTIDEASETILKL 312
Cdd:COG0438     4 LVPRKGLDLLleALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVppGDPEALAEAILRL 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1704621086 313 VKSYDSLIEIKTKAVGTARKiSFSeeVDALADKVLQM 349
Cdd:COG0438    84 LEDPELRRRLGEAARERAEE-RFS--WEAIAERLLAL 117
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 185-326 4.66e-13

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 66.14  E-value: 4.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 185 QYDLIYFLRQDPRKRIDRFEEMLPYLYENNISILCV--------------TQSLDLADRYssqlpVFIPE-NDQELISLI 249
Cdd:pfam00534   2 KKIILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLViagdgeeekrlkklAEKLGLGDNV-----IFLGFvSDEDLPELL 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1704621086 250 DKCKIYLLTSSQEGFSLPPLECMARGVIPVVFECGGPEIYIEDGLNGFIV--NTIDEASETILKLVKSYDSLIEIKTKA 326
Cdd:pfam00534  77 KIADVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVkpNNAEALAEAIDKLLEDEELRERLGENA 155
PLN02949 PLN02949
transferase, transferring glycosyl groups
 262-337 5.67e-04

transferase, transferring glycosyl groups


Pssm-ID: 215511 [Multi-domain]  Cd Length: 463  Bit Score: 41.65  E-value: 5.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 262 EGFSLPPLECMARGVIPVVFECGGPEIYI---EDGLN-GFIVNTIDEASETILKLVKSYDSLIEiKTKAVGTARKISFSE 337
Cdd:PLN02949  365 EHFGISVVEYMAAGAVPIAHNSAGPKMDIvldEDGQQtGFLATTVEEYADAILEVLRMRETERL-EIAAAARKRANRFSE 443
 
Name Accession Description Interval E-value
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 11-339 1.49e-18

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 85.37  E-value: 1.49e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086  11 SISNHGGV-RILLQIANSIANKGGRTKIICPKGTYD-TRYNISDKVEIIEVGPAISNKICRWF-FFTILFPF--YVKNND 85
Cdd:cd03820     8 SISNAGGAeRVAINLANHLAKKGYDVTIISLDSAEKpPFYELDDNIKIKNLGDRKYSHFKLLLkYFKKVRRLrkYLKNNK 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086  86 tvfANFFVTFYASLLSRILFKKIKIVYFIQD-IEYEFFGGLIKKIAKKLCEYSYAYK-----KAEIIAANIYLYERLLVK 159
Cdd:cd03820    88 ---PDVVISFRTSLLTFLALIGLKSKLIVWEhNNYEAYNKGLRRLLLRRLLYKRADKivvltEADKLKKYKQPNSNVVVI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 160 NDAIKLFNVWI-----DEKFITTASVETHRQYDL---IYFLRQDPRK----RI----DRfEEMLpylyENNIsilcvtQS 223
Cdd:cd03820   165 PNPLSFPSEEPstnlkSKRILAVGRLTYQKGFDLlieAWALIAKKHPdwklRIygdgPE-REEL----EKLI------DK 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 224 LDLADRyssqlpVFIPENDQELISLIDKCKIYLLTSSQEGFSLPPLECMARGVIPVVFEC-GGPEIYIEDGLNGFIVNT- 301
Cdd:cd03820   234 LGLEDR------VKLLGPTKNIAEEYANSSIFVLSSRYEGFPMVLLEAMAYGLPIISFDCpTGPSEIIEDGENGLLVPNg 307

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1704621086 302 -IDEASETILKLVKSYDSLIEIKTKAVGTARKisFSEEV 339
Cdd:cd03820   308 dVDALAEALLRLMEDEELRKKMGKNARKNAER--FSIEK 344
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 16-314 2.23e-16

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 79.12  E-value: 2.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086  16 GGVRILLQIANSIANKGGRTKIICPKGTYDTRYNISDKVEIIEVGPAISNKICRWFFFTILFPFYVKNNDTVFANFFVTF 95
Cdd:cd03801    15 GAERHVRELARALAARGHDVTVLTPADPGEPPEELEDGVIVPLLPSLAALLRARRLLRELRPLLRLRKFDVVHAHGLLAA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086  96 YASLLSRILfKKIKIVYFIQDIEYEFFGGLIKKIAKKLCEYSYAYKKA-EIIAANIYLYERLL----VKNDAIKLFNVWI 170
Cdd:cd03801    95 LLAALLALL-LGAPLVVTLHGAEPGRLLLLLAAERRLLARAEALLRRAdAVIAVSEALRDELRalggIPPEKIVVIPNGV 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 171 D-EKFITTASVETHRQYDLIYFL---RQDPRKRIDRFEEMLPYL--YENNISILCVTQSLDLADRYSSQLP------VFI 238
Cdd:cd03801   174 DlERFSPPLRRKLGIPPDRPVLLfvgRLSPRKGVDLLLEALAKLlrRGPDVRLVIVGGDGPLRAELEELELglgdrvRFL 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 239 PE-NDQELISLIDKCKIYLLTSSQEGFSLPPLECMARGVIPVVFECGG-PEIyIEDGLNGFIVNTIDEAS--ETILKLVK 314
Cdd:cd03801   254 GFvPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGlPEV-VEDGEGGLVVPPDDVEAlaDALLRLLA 332
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 237-349 3.36e-13

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 65.40  E-value: 3.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 237 FIPENDQELI--SLIDKCKIYLLTSSQEGFSLPPLECMARGVIPVVFECGGPEIYIEDGLNGFIV--NTIDEASETILKL 312
Cdd:COG0438     4 LVPRKGLDLLleALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVppGDPEALAEAILRL 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1704621086 313 VKSYDSLIEIKTKAVGTARKiSFSeeVDALADKVLQM 349
Cdd:COG0438    84 LEDPELRRRLGEAARERAEE-RFS--WEAIAERLLAL 117
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 185-326 4.66e-13

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 66.14  E-value: 4.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 185 QYDLIYFLRQDPRKRIDRFEEMLPYLYENNISILCV--------------TQSLDLADRYssqlpVFIPE-NDQELISLI 249
Cdd:pfam00534   2 KKIILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLViagdgeeekrlkklAEKLGLGDNV-----IFLGFvSDEDLPELL 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1704621086 250 DKCKIYLLTSSQEGFSLPPLECMARGVIPVVFECGGPEIYIEDGLNGFIV--NTIDEASETILKLVKSYDSLIEIKTKA 326
Cdd:pfam00534  77 KIADVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVkpNNAEALAEAIDKLLEDEELRERLGENA 155
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 4-300 3.74e-12

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 66.61  E-value: 3.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086   4 NVIFPMLSISNHGGVRILLQIANSIANKGGRTKIICPKGTYDTRYNISDKVEIIEVGPAISNKICRWFFFTIL-FPFYVK 82
Cdd:cd03811     1 KILFVIPSLSGGGAERVLLNLANALDKRGYDVTLVLLRDEGDLDKQLNGDVKLIRLLIRVLKLIKLGLLKAILkLKRILK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086  83 NN--DTVFAN-FFVTFYASLLSRILFKKIKIVYFIQDIEYEFFgglikkiaKKLCEYSYAYKKAEIIAANIYLYERLLVK 159
Cdd:cd03811    81 RAkpDVVISFlGFATYIVAKLAAARSKVIAWIHSSLSKLYYLK--------KKLLLKLKLYKKADKIVCVSKGIKEDLIR 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 160 NDAIKLFNVW-----IDEKFITTASVETHRQY--DLIYFL---RQDPRKRIDRFEEMLPYLYENNISILCV--------- 220
Cdd:cd03811   153 LGPSPPEKIEviynpIDIDRIRALAKEPILNEpeDGPVILavgRLDPQKGHDLLIEAFAKLRKKYPDVKLVilgdgplre 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 221 -----TQSLDLADRyssqlpVFIPENDQELISLIDKCKIYLLTSSQEGFSLPPLECMARGVIPVVFECGGPEIYIEDGLN 295
Cdd:cd03811   233 eleklAKELGLAER------VIFLGFQSNPYPYLKKADLFVLSSRYEGFPNVLLEAMALGTPVVSTDCPGPREILDDGEN 306


                  ....*
gi 1704621086 296 GFIVN 300
Cdd:cd03811   307 GLLVP 311
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 183-299 3.91e-09

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 56.26  E-value: 3.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 183 HRQYDLIYFLRQDPRKRIDRFEEMLPYLYENNISILCV----------TQSLDLADRYSSQLPVFIPENDQELISLI-DK 251
Cdd:cd01635   108 LPLADKVSVGRLVPEKGIDLLLEALALLKARLPDLVLVlvggggereeEEALAAALGLLERVVIIGGLVDDEVLELLlAA 187

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1704621086 252 CKIYLLTSSQEGFSLPPLECMARGVIPVVFECGGPEIYIEDGLNGFIV 299
Cdd:cd01635   188 ADVFVLPSRSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGLLV 235
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
243-314 1.06e-08

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 53.28  E-value: 1.06e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1704621086 243 QELISLIDKCKIYLLTSSQEGFSLPPLECMARGViPVV-FECGG-PEIYieDGLNGFIVNTIDEAS--ETILKLVK 314
Cdd:pfam13692  65 EDLAELLAAADVFVLPSLYEGFGLKLLEAMAAGL-PVVaTDVGGiPELV--DGENGLLVPPGDPEAlaEAILRLLE 137
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 9-280 4.83e-08

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 53.91  E-value: 4.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086   9 MLSISNHGGVRILLQIANSIA-NKGGRTKIICPKGTYDTRYNISDKVEIIEVGPAISNKICRWFFFTILFPFYVKNNDTV 87
Cdd:cd03809     8 SLAQRLTGIGRYTRELLKALAkNDPDESVLAVPPLPGELLRLLREYPELSLGVIKIKLWRELALLRWLQILLPKKDKPDL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086  88 FanffvtFYASLLSRILFKKIKIVYFIQDIEY----EFFGGLIKKIAKKLceYSYAYKKAEIIAANIYLyerllVKNDAI 163
Cdd:cd03809    88 L------HSPHNTAPLLLKGCPQVVTIHDLIPlrypEFFPKRFRLYYRLL--LPISLRRADAIITVSEA-----TRDDII 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 164 KLFNV---WI--------DEKFITTASVETHRQYDLI--YFL---RQDPRKRIDR-FE--EMLPYLYeNNISILCVTQS- 223
Cdd:cd03809   155 KFYGVppeKIvviplgvdPSFFPPESAAVLIAKYLLPepYFLyvgTLEPRKNHERlLKafALLKKQG-GDLKLVIVGGKg 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1704621086 224 ------LDLADRYSSQLPVFIPEN--DQELISLIDKCKIYLLTSSQEGFSLPPLECMARGViPVV 280
Cdd:cd03809   234 wedeelLDLVKKLGLGGRVRFLGYvsDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGT-PVI 297
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 37-326 2.14e-07

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 51.83  E-value: 2.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086  37 IICPKGTYDTRYNISDKVEIIEVGPAISNKICRWFFFTIL-FPFYVKNN--DTVFANFFVT-FYASLLSRILFKKiKIVY 112
Cdd:cd03808    32 VIAPDGDKLSDELKELGVKVIDIPILRRGINPLKDLKALFkLYKLLKKEkpDIVHCHTPKPgILGRLAARLAGVP-KVIY 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 113 FIQDIEYEFFGGLIKKIAKKLCEYSYAYKKAEIIAANIYLYERLLVK-----NDAIKLFNVWIDEKFITTASVET-HRQY 186
Cdd:cd03808   111 TVHGLGFVFTEGKLLRLLYLLLEKLALLFTDKVIFVNEDDRDLAIKKgiikkKKTVLIPGSGVDLDRFQYSPESLpSEKV 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 187 DLIYFLRQDPRKRIDRFEEMLPYLYENNISI-LCVTQSLDLADRYSSQLPVFIPEND-------QELISLIDKCKIYLLT 258
Cdd:cd03808   191 VFLFVARLLKDKGIDELIEAAKILKKKGPNVrFLLVGDGELENPSEILIEKLGLEGRieflgfrSDVPELLAESDVFVLP 270

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1704621086 259 SSQEGFSLPPLECMARGVIPVVFECGG-PEIyIEDGLNGFIVNTIDEAS--ETILKLVKSYDSLIEIKTKA 326
Cdd:cd03808   271 SYREGLPRSLLEAMAAGRPVITTDVPGcREL-VIDGVNGFLVPPGDVEAlaDAIEKLIEDPELRKEMGEAA 340
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 243-332 6.76e-07

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 50.43  E-value: 6.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 243 QELISLIDkckIYLLTSSQEGFSLPPLECMARGVIPVVFECGG-PEIyIEDGLNGFIVNT--IDEASETILKLVKSYDSL 319
Cdd:cd04962   264 EELLSIAD---LFLLPSEKESFGLAALEAMACGVPVVSSNAGGiPEV-VKHGETGFLSDVgdVDAMAKSALSILEDDELY 339

                          90
                  ....*....|...
gi 1704621086 320 IEIKTKAVGTARK 332
Cdd:cd04962   340 NRMGRAARKRAAE 352
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 241-312 7.63e-07

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 50.36  E-value: 7.63e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1704621086 241 NDQELISLIDKCKIYLLTSS-QEGFSLPPLECMARGViPVV-FECGG-PEIyIEDGLNGFIVNTIDEASETILKL 312
Cdd:cd03802   229 GHDEKQELLGGARALLFPINwDEPFGLVMIEAMACGT-PVIaYRRGGlPEV-IQHGETGFLVDSVEEMAEAIANI 301
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 253-338 1.11e-06

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 49.61  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 253 KIYLLTSSQEGFSLPPLECMARGVIPVVFECG-GPEIYIEDGLNGFIV--NTIDEASETILKLVKSYDSLIEIKTKAVGT 329
Cdd:cd04949   236 YLSLLTSQMEGFGLTLMEAIGHGLPVVSYDVKyGPSELIEDGENGYLIekNNIDALADKIIELLNDPEKLQQFSEESYKI 315


                  ....*....
gi 1704621086 330 ARKisFSEE 338
Cdd:cd04949   316 AEK--YSTE 322
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 239-314 1.61e-05

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 46.16  E-value: 1.61e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1704621086 239 PENDQELISLIDKCKIYLLTSSQEGFSLPPLECMARGVIPVVFECGGPEIYIEDGLNGFIVNTIDEASETILKLVK 314
Cdd:cd03792   267 PPSDQEINALQRAATVVLQLSTREGFGLTVSEALWKGKPVIATPAGGIPLQVIDGETGFLVNSVEGAAVRILRLLT 342
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 220-315 2.59e-05

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 45.69  E-value: 2.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 220 VTQSLDLADRYssQLPVFIpeNDQELISLIDKCKIYLLTSSQEGFSLPPLECMARGViPVVFEC-GGPEIYIEDGLNGFI 298
Cdd:cd03800   275 LAEELGLIDRV--RFPGRV--SRDDLPELYRAADVFVVPSLYEPFGLTAIEAMACGT-PVVATAvGGLQDIVRDGRTGLL 349

                          90
                  ....*....|....*....
gi 1704621086 299 VNTIDEAS--ETILKLVKS 315
Cdd:cd03800   350 VDPHDPEAlaAALRRLLDD 368
GT4_ALG11-like cd03806
alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related ...
 243-339 7.48e-05

alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown to block the early steps of core biosynthesis that takes place on the cytoplasmic face of the ER and lead to a defect in the assembly of lipid-linked oligosaccharides.


Pssm-ID: 340835 [Multi-domain]  Cd Length: 419  Bit Score: 44.14  E-value: 7.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 243 QELISLIDKCKIYLLTSSQEGFSLPPLECMARGVIPVVFECGGPEIYI----EDGLNGFIVNTIDEASETILKLVKSYDS 318
Cdd:cd03806   316 EELKELLSTASIGLHTMWNEHFGIGVVEYMAAGLIPLAHASAGPLLDIvvpwDGGPTGFLASTPEEYAEAIEKILTLSEE 395

                          90       100
                  ....*....|....*....|..
gi 1704621086 319 -LIEIKTKAVGTARKisFSEEV 339
Cdd:cd03806   396 eRLQRREAARSSAER--FSDEE 415
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 94-346 1.26e-04

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 43.42  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086  94 TFYASLlsRILFKKIKIVYFIQDIeYEFFGGLI---KKIAKKLCEYSYaYKKAEIIAANIYLYERLLVKNDAIKLFNVWI 170
Cdd:cd03817   123 LHYIPK--GKLLVKAVVRKLVRRF-YNHTDAVIapsEKIKDTLREYGV-KGPIEVIPNGIDLDKFEKPLNTEERRKLGLP 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 171 DEKFIttasvethrqydLIYFLRQDPRKRIDRFEEMLPYL-YENNISILCV-----TQSLD-LADRYSSQLPV----FIP 239
Cdd:cd03817   199 PDEPI------------LLYVGRLAKEKNIDFLLRAFAELkKEPNIKLVIVgdgpeREELKeLARELGLADKViftgFVP 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 240 ENdqELISLIDKCKIYLLTSSQEGFSLPPLECMARGViPVVFECGG--PEIyIEDGLNGFIVNTIDE-ASETILKLVKSY 316
Cdd:cd03817   267 RE--ELPEYYKAADLFVFASTTETQGLVYLEAMAAGL-PVVAAKDPaaSEL-VEDGENGFLFEPNDEtLAEKLLHLRENL 342

                         250       260       270
                  ....*....|....*....|....*....|
gi 1704621086 317 DSLIEIKTKAVGTARKISFSEEVDALADKV 346
Cdd:cd03817   343 ELLRKLSKNAEISAREFAFAKSVEKLYEEV 372
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 95-319 3.10e-04

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 42.30  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086  95 FYASLLSRI---LFKKIKIVYFIQDI-EYEFFGGLIKKIAKKLCEYSYAY-----KKAEIIAANIYLYERLLVKNDAIKL 165
Cdd:cd03807    88 YHADLIGGLaakLAGGVKVIWSVRSSnIPQRLTRLVRKLCLLLSKFSPATvanssAVAEFHQEQGYAKNKIVVIYNGIDL 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 166 FNVWIDEK----FITTASVETHRqYDLIYFLRQDPRKRIDRFEEMLPYLYEN--NISILCV------TQSLDLADRYSSQ 233
Cdd:cd03807   168 FKLSPDDAsrarARRRLGLAEDR-RVIGIVGRLHPVKDHSDLLRAAALLVEThpDLRLLLVgrgperPNLERLLLELGLE 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 234 LPVFIPENDQELISLIDKCKIYLLTSSQEGFSLPPLECMARGVIPVVFECGG-PEIyIEDGlNGFIV-----NTIDEASE 307
Cdd:cd03807   247 DRVHLLGERSDVPALLPAMDIFVLSSRTEGFPNALLEAMACGLPVVATDVGGaAEL-VDDG-TGFLVpagdpQALADAIR 324

                         250
                  ....*....|..
gi 1704621086 308 TILKLVKSYDSL 319
Cdd:cd03807   325 ALLEDPEKRARL 336
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
 236-314 3.50e-04

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 42.19  E-value: 3.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 236 VFIPE-NDQELISLIDKCKIYLLTSSQEGFSLPPLECMARGViPVVfEC--GGPEIYIEDGLNGFIV-NTIDEASETILK 311
Cdd:cd03805   283 LFLRSiSDSQKEQLLSSALALLYTPSNEHFGIVPLEAMYAGK-PVI-ACnsGGPLETVVEGVTGFLCePTPEAFAEAMLK 360


                  ...
gi 1704621086 312 LVK 314
Cdd:cd03805   361 LAN 363
PLN02949 PLN02949
transferase, transferring glycosyl groups
 262-337 5.67e-04

transferase, transferring glycosyl groups


Pssm-ID: 215511 [Multi-domain]  Cd Length: 463  Bit Score: 41.65  E-value: 5.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 262 EGFSLPPLECMARGVIPVVFECGGPEIYI---EDGLN-GFIVNTIDEASETILKLVKSYDSLIEiKTKAVGTARKISFSE 337
Cdd:PLN02949  365 EHFGISVVEYMAAGAVPIAHNSAGPKMDIvldEDGQQtGFLATTVEEYADAILEVLRMRETERL-EIAAAARKRANRFSE 443
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 159-299 5.84e-04

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 41.55  E-value: 5.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 159 KNDAIKLFNVWIDEKFITTASVETHrqydliyflrqDPRKRIDRFEEMLPYLYENNISILCVTQSLDLADRYSSQLPVFI 238
Cdd:cd03825   180 KAKARKRLGIPQDKKVILFGAESVT-----------KPRKGFDELIEALKLLATKDDLLLVVFGKNDPQIVILPFDIISL 248

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1704621086 239 P--ENDQELISLIDKCKIYLLTSSQEGFSLPPLECMARGVIPVVFECGG-PEIyIEDGLNGFIV 299
Cdd:cd03825   249 GyiDDDEQLVDIYSAADLFVHPSLADNLPNTLLEAMACGTPVVAFDTGGsPEI-VQHGVTGYLV 311
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 252-299 9.63e-04

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 40.83  E-value: 9.63e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1704621086 252 CKIYLLTSSQEGFSLPPLECMARGViPVV-FECGGPEIYIEDGLNGFIV 299
Cdd:cd03798   277 CDVFVLPSRHEGFGLVLLEAMACGL-PVVaTDVGGIPEVVGDPETGLLV 324
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
256-327 5.18e-03

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 38.54  E-value: 5.18e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1704621086 256 LLTSSQEGFSLPPLECMARGVIPVVFEC-GGPEIYIEDGLNGFIVN--TIDEASEtilKLVKSYDSLIEIKTKAV 327
Cdd:PRK09922  262 LLTSKFEGFPMTLLEAMSYGIPCISSDCmSGPRDIIKPGLNGELYTpgNIDEFVG---KLNKVISGEVKYQHDAI 333
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 16-326 8.63e-03

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 37.71  E-value: 8.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086  16 GGVRILLQIANSIANKGGRTKIICPKGTYDTRYNIS------DKVEIIEV------GPAISNKICRWFFFT----ILFPF 79
Cdd:cd03794    15 AAAARVYELAKELVRRGHEVTVLTPSPNYPLGRIFAgatetkDGIRVIRVklgpikKNGLIRRLLNYLSFAlaalLKLLV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086  80 YVKNNDTVFAN---FFVTFYASLLSRilFKKIKIVYFIQDIEYEFF---GGLIKKIAKKLCEY--SYAYKKAE-IIAANI 150
Cdd:cd03794    95 REERPDVIIAYsppITLGLAALLLKK--LRGAPFILDVRDLWPESLialGVLKKGSLLKLLKKleRKLYRLADaIIVLSP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 151 YLYERLLVKNDAIKLFNV---WIDEKFITTASVETHRQY-------DLIYF----LRQDPRKRIDRFEEMLPYlyeNNIS 216
Cdd:cd03794   173 GLKEYLLRKGVPKEKIIVipnWADLEEFKPPPKDELRKKlglddkfVVVYAgnigKAQGLETLLEAAERLKRR---PDIR 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1704621086 217 ILCVTQ------SLDLADRYSSQLPVFIPE-NDQELISLIDKCKIYLLT---SSQEGFSLP--PLECMARGvIPVVFEC- 283
Cdd:cd03794   250 FLFVGDgdekerLKELAKARGLDNVTFLGRvPKEEVPELLSAADVGLVPlkdNPANRGSSPskLFEYMAAG-KPILASDd 328

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1704621086 284 GGPEIYIEDGLNGFIVNT--IDEASETILKLVKSYDSLIEIKTKA 326
Cdd:cd03794   329 GGSDLAVEINGCGLVVEPgdPEALADAILELLDDPELRRAMGENG 373
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH