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Conserved domains on  [gi|1702047045|ref|XP_029795719|]
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toll-like receptor 2 [Suricata suricatta]

Protein Classification

toll-like receptor( domain architecture ID 11471630)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-785 2.76e-41

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 147.47  E-value: 2.76e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045  641 CYDAFVSYSERDshWVENLMVQELEHFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTIFVLSENFVKSEWCRYELDF 720
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1702047045  721 SHFRLFDENNDAVILILLEPIeKKAIPQRFCKLRKIMnTRTYLEWPTDEAQQegFWLNLRAAIKS 785
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVI-PSDVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPS 139
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
214-564 2.04e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 2.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 214 LLEIFIDLLSSVEHLELRDTHLNTLHFSKASINETNTLIKKWTFRNVKITDVSFSELAKLLNYVSGVLEVEFEDCTLHGL 293
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 294 GDFDVSDMGEIGSVSGIETLTVRRLEipffySFYDLSSVYSLTGRVKRITVesskvflVPCLLSQhLKSLEYLDLSDNLM 373
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTD-------LPEELAN-LTNLKELDLSNNQL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 374 --VEEYLRNaacehaWPLLQTLILRQNRLKSLektGEILLTLKNLINLDISKNGYLSMPETCQWPEKLKYLNLSNTRIHS 451
Cdd:COG4886   149 tdLPEPLGN------LTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTD 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 452 LTRCIPW--TLEILDISNNNLDSFS--LTFPQLKELYISRNKLKTLPDASFLPMLQVMRISRNTVNTFSKEQLDSFQRLM 527
Cdd:COG4886   220 LPEPLANltNLETLDLSNNQLTDLPelGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLN 299

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1702047045 528 TLEVGGNNFICSCEFLSFTQEQQALAQILIDWPDNYL 564
Cdd:COG4886   300 SLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-304 1.27e-10

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 1.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045  44 LTSVPAGLTA--AVRSLDLSNNEITYLGnSDLRGCVNLRALRLEANKINTIEEdSFFPLGSLEHLDLSYNNISSLSSSwF 121
Cdd:COG4886   125 LTDLPEELANltNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEP-L 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 122 RPLSSLNFLNLLGNPYKSLGQTplFSQLTTLRILKVGNTySFTEIqkTDFVGLTFLEELEIDATNLQKYEPksLKSIQNI 201
Cdd:COG4886   202 GNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNN-QLTDL--PELGNLTNLEELDLSNNQLTDLPP--LANLTNL 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 202 SHLALRMKQPDFLLEIFIDLLSSVEHLELRDTHLNTLHFSKASINETNTLIKKWTFRNVKITDVSFSELAKLLNYVSGVL 281
Cdd:COG4886   275 KTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLL 354

                         250       260
                  ....*....|....*....|...
gi 1702047045 282 EVEFEDCTLHGLGDFDVSDMGEI 304
Cdd:COG4886   355 LLNLLSLLLTLLLTLGLLGLLEA 377
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-785 2.76e-41

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 147.47  E-value: 2.76e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045  641 CYDAFVSYSERDshWVENLMVQELEHFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTIFVLSENFVKSEWCRYELDF 720
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1702047045  721 SHFRLFDENNDAVILILLEPIeKKAIPQRFCKLRKIMnTRTYLEWPTDEAQQegFWLNLRAAIKS 785
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVI-PSDVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPS 139
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 642-785 1.87e-21

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 92.04  E-value: 1.87e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 642 YDAFVSYSERDS-HWVENLMVQELEHFNppFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTIFVLSENFVKSEWCRYELDF 720
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKG--IKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 721 S-HFRLfdENNDAVILILLEPIE------KKAIPQRFCKLRKIMNTRTYLEWP---TDEAQQEG---------FWLNLRA 781
Cdd:pfam01582  79 IlECAL--DLGQKVIPIFYEVDPsdvrkqTGSFGKAFKKHKKVLTEEKVLKWRgalNEVANIWHsksvsdeskFWKKIAY 156


                  ....
gi 1702047045 782 AIKS 785
Cdd:pfam01582 157 DISN 160
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
214-564 2.04e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 2.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 214 LLEIFIDLLSSVEHLELRDTHLNTLHFSKASINETNTLIKKWTFRNVKITDVSFSELAKLLNYVSGVLEVEFEDCTLHGL 293
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 294 GDFDVSDMGEIGSVSGIETLTVRRLEipffySFYDLSSVYSLTGRVKRITVesskvflVPCLLSQhLKSLEYLDLSDNLM 373
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTD-------LPEELAN-LTNLKELDLSNNQL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 374 --VEEYLRNaacehaWPLLQTLILRQNRLKSLektGEILLTLKNLINLDISKNGYLSMPETCQWPEKLKYLNLSNTRIHS 451
Cdd:COG4886   149 tdLPEPLGN------LTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTD 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 452 LTRCIPW--TLEILDISNNNLDSFS--LTFPQLKELYISRNKLKTLPDASFLPMLQVMRISRNTVNTFSKEQLDSFQRLM 527
Cdd:COG4886   220 LPEPLANltNLETLDLSNNQLTDLPelGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLN 299

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1702047045 528 TLEVGGNNFICSCEFLSFTQEQQALAQILIDWPDNYL 564
Cdd:COG4886   300 SLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
334-559 1.02e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 75.12  E-value: 1.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 334 SLTGRVKRITVESSKVFLVPCLLSQhlkSLEYLDLSDNLMVE--EYLRNAacehawplLQTLILRQNRLKSLEKTgeill 411
Cdd:PRK15370  217 NLQGNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITElpERLPSA--------LQSLDLFHNKISCLPEN----- 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 412 TLKNLINLDISKNGYLSMPEtcQWPEKLKYLNLSNTRIHSLTRCIPWTLEILDISNNNLDSFSLTFP-QLKELYISRNKL 490
Cdd:PRK15370  281 LPEELRYLSVYDNSIRTLPA--HLPSGITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASLPpELQVLDVSKNQI 358

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 491 KTLPDaSFLPMLQVMRISRNTVNTFSkEQLDSfqRLMTLEVGGNNFICSCEFL-SFTQEQQALAQILIDW 559
Cdd:PRK15370  359 TVLPE-TLPPTITTLDVSRNALTNLP-ENLPA--ALQIMQASRNNLVRLPESLpHFRGEGPQPTRIIVEY 424
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-304 1.27e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 1.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045  44 LTSVPAGLTA--AVRSLDLSNNEITYLGnSDLRGCVNLRALRLEANKINTIEEdSFFPLGSLEHLDLSYNNISSLSSSwF 121
Cdd:COG4886   125 LTDLPEELANltNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEP-L 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 122 RPLSSLNFLNLLGNPYKSLGQTplFSQLTTLRILKVGNTySFTEIqkTDFVGLTFLEELEIDATNLQKYEPksLKSIQNI 201
Cdd:COG4886   202 GNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNN-QLTDL--PELGNLTNLEELDLSNNQLTDLPP--LANLTNL 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 202 SHLALRMKQPDFLLEIFIDLLSSVEHLELRDTHLNTLHFSKASINETNTLIKKWTFRNVKITDVSFSELAKLLNYVSGVL 281
Cdd:COG4886   275 KTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLL 354

                         250       260
                  ....*....|....*....|...
gi 1702047045 282 EVEFEDCTLHGLGDFDVSDMGEI 304
Cdd:COG4886   355 LLNLLSLLLTLLLTLGLLGLLEA 377
LRR_8 pfam13855
Leucine rich repeat;
55-113 7.24e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 7.24e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1702047045  55 VRSLDLSNNEITYLGNSDLRGCVNLRALRLEANKINTIEEDSFFPLGSLEHLDLSYNNI 113
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
534-587 7.51e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.88  E-value: 7.51e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1702047045  534 NNFICSCEFLSFTQEQQalAQILIDWPDNYLCDSPFYVRGQRVQDTHLPASeCH 587
Cdd:smart00082   1 NPFICDCELRWLLRWLQ--ANEHLQDPVDLRCASPSSLRGPLLELLHSEFK-CP 51
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 359-517 1.95e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 359 HLKSLEYLDLSDNLMveEYLRNaaCEHAwPLLQTLILRQNRLKSLEKtgeiLLTLKNLINLDISKNgYLSMPETCQWPEK 438
Cdd:cd21340    22 LCKNLKVLYLYDNKI--TKIEN--LEFL-TNLTHLYLQNNQIEKIEN----LENLVNLKKLYLGGN-RISVVEGLENLTN 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 439 LKYLNLSNTRI---HSLT---RCIPW---TLEILDISNNNLDSFS--LTFPQLKELYISRNKLKTLPDASFL----PMLQ 503
Cdd:cd21340    92 LEELHIENQRLppgEKLTfdpRSLAAlsnSLRVLNISGNNIDSLEplAPLRNLEQLDASNNQISDLEELLDLlsswPSLR 171

                         170
                  ....*....|....
gi 1702047045 504 VMRISRNTVNTFSK 517
Cdd:cd21340   172 ELDLTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
478-536 2.13e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 2.13e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1702047045 478 PQLKELYISRNKLKTLPDASF--LPMLQVMRISRNTVNTFSKEQLDSFQRLMTLEVGGNNF 536
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 58-117 8.80e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 8.80e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045  58 LDLSNNEITYLGNsdLRGCVNLRALRLEANKINTIEedSFFPLGSLEHLDLSYNNISSLS 117
Cdd:cd21340    29 LYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE 84
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-785 2.76e-41

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 147.47  E-value: 2.76e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045  641 CYDAFVSYSERDshWVENLMVQELEHFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTIFVLSENFVKSEWCRYELDF 720
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1702047045  721 SHFRLFDENNDAVILILLEPIeKKAIPQRFCKLRKIMnTRTYLEWPTDEAQQegFWLNLRAAIKS 785
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVI-PSDVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPS 139
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 642-785 1.87e-21

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 92.04  E-value: 1.87e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 642 YDAFVSYSERDS-HWVENLMVQELEHFNppFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTIFVLSENFVKSEWCRYELDF 720
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKG--IKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 721 S-HFRLfdENNDAVILILLEPIE------KKAIPQRFCKLRKIMNTRTYLEWP---TDEAQQEG---------FWLNLRA 781
Cdd:pfam01582  79 IlECAL--DLGQKVIPIFYEVDPsdvrkqTGSFGKAFKKHKKVLTEEKVLKWRgalNEVANIWHsksvsdeskFWKKIAY 156


                  ....
gi 1702047045 782 AIKS 785
Cdd:pfam01582 157 DISN 160
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
214-564 2.04e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 2.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 214 LLEIFIDLLSSVEHLELRDTHLNTLHFSKASINETNTLIKKWTFRNVKITDVSFSELAKLLNYVSGVLEVEFEDCTLHGL 293
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 294 GDFDVSDMGEIGSVSGIETLTVRRLEipffySFYDLSSVYSLTGRVKRITVesskvflVPCLLSQhLKSLEYLDLSDNLM 373
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTD-------LPEELAN-LTNLKELDLSNNQL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 374 --VEEYLRNaacehaWPLLQTLILRQNRLKSLektGEILLTLKNLINLDISKNGYLSMPETCQWPEKLKYLNLSNTRIHS 451
Cdd:COG4886   149 tdLPEPLGN------LTNLKSLDLSNNQLTDL---PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTD 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 452 LTRCIPW--TLEILDISNNNLDSFS--LTFPQLKELYISRNKLKTLPDASFLPMLQVMRISRNTVNTFSKEQLDSFQRLM 527
Cdd:COG4886   220 LPEPLANltNLETLDLSNNQLTDLPelGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLN 299

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1702047045 528 TLEVGGNNFICSCEFLSFTQEQQALAQILIDWPDNYL 564
Cdd:COG4886   300 SLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 645-740 8.02e-15

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 71.19  E-value: 8.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 645 FVSYSERDSHWVENLmVQELEhfNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTIFVLSENFVKSEWCRYELDfsHFR 724
Cdd:pfam13676   2 FISYAGEDRAWAEWL-ADALE--AAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWE--AAL 76

                          90
                  ....*....|....*.
gi 1702047045 725 LFDENNDAVILILLEP 740
Cdd:pfam13676  77 ADPEGRKRLIPVRLEC 92
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
334-559 1.02e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 75.12  E-value: 1.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 334 SLTGRVKRITVESSKVFLVPCLLSQhlkSLEYLDLSDNLMVE--EYLRNAacehawplLQTLILRQNRLKSLEKTgeill 411
Cdd:PRK15370  217 NLQGNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITElpERLPSA--------LQSLDLFHNKISCLPEN----- 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 412 TLKNLINLDISKNGYLSMPEtcQWPEKLKYLNLSNTRIHSLTRCIPWTLEILDISNNNLDSFSLTFP-QLKELYISRNKL 490
Cdd:PRK15370  281 LPEELRYLSVYDNSIRTLPA--HLPSGITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASLPpELQVLDVSKNQI 358

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 491 KTLPDaSFLPMLQVMRISRNTVNTFSkEQLDSfqRLMTLEVGGNNFICSCEFL-SFTQEQQALAQILIDW 559
Cdd:PRK15370  359 TVLPE-TLPPTITTLDVSRNALTNLP-ENLPA--ALQIMQASRNNLVRLPESLpHFRGEGPQPTRIIVEY 424
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-304 1.27e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 1.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045  44 LTSVPAGLTA--AVRSLDLSNNEITYLGnSDLRGCVNLRALRLEANKINTIEEdSFFPLGSLEHLDLSYNNISSLSSSwF 121
Cdd:COG4886   125 LTDLPEELANltNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEP-L 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 122 RPLSSLNFLNLLGNPYKSLGQTplFSQLTTLRILKVGNTySFTEIqkTDFVGLTFLEELEIDATNLQKYEPksLKSIQNI 201
Cdd:COG4886   202 GNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNN-QLTDL--PELGNLTNLEELDLSNNQLTDLPP--LANLTNL 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 202 SHLALRMKQPDFLLEIFIDLLSSVEHLELRDTHLNTLHFSKASINETNTLIKKWTFRNVKITDVSFSELAKLLNYVSGVL 281
Cdd:COG4886   275 KTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLL 354

                         250       260
                  ....*....|....*....|...
gi 1702047045 282 EVEFEDCTLHGLGDFDVSDMGEI 304
Cdd:COG4886   355 LLNLLSLLLTLLLTLGLLGLLEA 377
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-281 4.04e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 4.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045  53 AAVRSLDLSNNEITYLGNSdLRGCVNLRALRLEANKINTIEEdSFFPLGSLEHLDLSYNNISSLSSSwfrplsslnflnl 132
Cdd:COG4886   113 TNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE------------- 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 133 lgnpykslgqtplFSQLTTLRILKVGNTySFTEIQKTdFVGLTFLEELEIDATNLqKYEPKSLKSIQNISHLALRMKQpd 212
Cdd:COG4886   178 -------------LGNLTNLKELDLSNN-QITDLPEP-LGNLTNLEELDLSGNQL-TDLPEPLANLTNLETLDLSNNQ-- 239

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1702047045 213 flLEIFIDL--LSSVEHLELRDTHLNTLHFSKasineTNTLIKKWTFRNVKITDVSFSELAKLLNYVSGVL 281
Cdd:COG4886   240 --LTDLPELgnLTNLEELDLSNNQLTDLPPLA-----NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL 303
LRR_8 pfam13855
Leucine rich repeat;
55-113 7.24e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 7.24e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1702047045  55 VRSLDLSNNEITYLGNSDLRGCVNLRALRLEANKINTIEEDSFFPLGSLEHLDLSYNNI 113
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
78-122 5.95e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 5.95e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1702047045  78 NLRALRLEANKINTIEEDSFFPLGSLEHLDLSYNNISSLSSSWFR 122
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS 46
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-238 3.69e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.93  E-value: 3.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045  44 LTSVPAGLTA--AVRSLDLSNNEITYLgnSDLRGCVNLRALRLEANKINTIEEDSffPLGSLEHLDLSYNNISSLSSSWF 121
Cdd:COG4886   217 LTDLPEPLANltNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKEL 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 122 RPLSSLNFLNLLGNPYKSLGQTPLFSQLTTLRILKVGNTYSFTEIQKTDFVGLTFLEELEIDATNLQKYEPKSLKSIQNI 201
Cdd:COG4886   293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1702047045 202 SHLALRMKQPDFLLEIFIDLLSSVEHLELRDTHLNTL 238
Cdd:COG4886   373 GLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409
LRRCT smart00082
Leucine rich repeat C-terminal domain;
534-587 7.51e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.88  E-value: 7.51e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1702047045  534 NNFICSCEFLSFTQEQQalAQILIDWPDNYLCDSPFYVRGQRVQDTHLPASeCH 587
Cdd:smart00082   1 NPFICDCELRWLLRWLQ--ANEHLQDPVDLRCASPSSLRGPLLELLHSEFK-CP 51
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 360-534 9.80e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.99  E-value: 9.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 360 LKSLEYLDLSDNLMVEEY------LRNAACEH---------------AWPLLQTLILRQNRLkslekTGEILLTL---KN 415
Cdd:PLN00113  283 LQKLISLDLSDNSLSGEIpelviqLQNLEILHlfsnnftgkipvaltSLPRLQVLQLWSNKF-----SGEIPKNLgkhNN 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 416 LINLDISKNGYLS-MPET-CQWPEKLKYLNLSNtrihSLTRCIPWTLE------------------------------IL 463
Cdd:PLN00113  358 LTVLDLSTNNLTGeIPEGlCSSGNLFKLILFSN----SLEGEIPKSLGacrslrrvrlqdnsfsgelpseftklplvyFL 433

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1702047045 464 DISNNNL----DSFSLTFPQLKELYISRNK-LKTLPDASFLPMLQVMRISRNTVNTFSKEQLDSFQRLMTLEVGGN 534
Cdd:PLN00113  434 DISNNNLqgriNSRKWDMPSLQMLSLARNKfFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSEN 509
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 359-517 1.95e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 359 HLKSLEYLDLSDNLMveEYLRNaaCEHAwPLLQTLILRQNRLKSLEKtgeiLLTLKNLINLDISKNgYLSMPETCQWPEK 438
Cdd:cd21340    22 LCKNLKVLYLYDNKI--TKIEN--LEFL-TNLTHLYLQNNQIEKIEN----LENLVNLKKLYLGGN-RISVVEGLENLTN 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 439 LKYLNLSNTRI---HSLT---RCIPW---TLEILDISNNNLDSFS--LTFPQLKELYISRNKLKTLPDASFL----PMLQ 503
Cdd:cd21340    92 LEELHIENQRLppgEKLTfdpRSLAAlsnSLRVLNISGNNIDSLEplAPLRNLEQLDASNNQISDLEELLDLlsswPSLR 171

                         170
                  ....*....|....
gi 1702047045 504 VMRISRNTVNTFSK 517
Cdd:cd21340   172 ELDLTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
478-536 2.13e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 2.13e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1702047045 478 PQLKELYISRNKLKTLPDASF--LPMLQVMRISRNTVNTFSKEQLDSFQRLMTLEVGGNNF 536
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 331-536 3.51e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 3.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 331 SVYSLTgrvKRITVESSKVFL---VPCLLSQhLKSLEYLDLSDNLMVEEYLRNAAcehAWPLLQTLILRQNRLkslekTG 407
Cdd:PLN00113  279 SIFSLQ---KLISLDLSDNSLsgeIPELVIQ-LQNLEILHLFSNNFTGKIPVALT---SLPRLQVLQLWSNKF-----SG 346

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 408 EILLTL---KNLINLDISKNGYLS-MPET-CQWPEKLKYLNLSNtrihSLTRCIPWTLE--------------------- 461
Cdd:PLN00113  347 EIPKNLgkhNNLTVLDLSTNNLTGeIPEGlCSSGNLFKLILFSN----SLEGEIPKSLGacrslrrvrlqdnsfsgelps 422

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 462 ---------ILDISNNNL----DSFSLTFPQLKELYISRNK-LKTLPDAS------------------------FLPMLQ 503
Cdd:PLN00113  423 eftklplvyFLDISNNNLqgriNSRKWDMPSLQMLSLARNKfFGGLPDSFgskrlenldlsrnqfsgavprklgSLSELM 502

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1702047045 504 VMRISRNTVNTFSKEQLDSFQRLMTLEVGGNNF 536
Cdd:PLN00113  503 QLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
388-534 3.95e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.00  E-value: 3.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 388 PLLQTLILRQNRLKSLEKTGEILLTL--------------KNLINLDISKNGYLSMPETcqwPEKLKYLNLSNTRIHSLT 453
Cdd:PRK15387  302 PGLQELSVSDNQLASLPALPSELCKLwaynnqltslptlpSGLQELSVSDNQLASLPTL---PSELYKLWAYNNRLTSLP 378

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 454 rCIPWTLEILDISNNNLDSFSLTFPQLKELYISRNKLKTLPdasFLPM-LQVMRISRNTVNTFSkEQLDSFQRLMTLEVG 532
Cdd:PRK15387  379 -ALPSGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLP---MLPSgLLSLSVYRNQLTRLP-ESLIHLSSETTVNLE 453


                  ..
gi 1702047045 533 GN 534
Cdd:PRK15387  454 GN 455
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 58-117 8.80e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 8.80e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045  58 LDLSNNEITYLGNsdLRGCVNLRALRLEANKINTIEedSFFPLGSLEHLDLSYNNISSLS 117
Cdd:cd21340    29 LYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE 84
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 58-116 1.34e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1702047045  58 LDLSNNEITYLGNsdLRGCVNLRALRLEANKINTIEEDSFFPlgSLEHLDLSYNNISSL 116
Cdd:cd21340     7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIENLEFLT--NLTHLYLQNNQIEKI 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-117 1.98e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 1.98e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1702047045  42 RSLTSVPAGLtaavRSLDLSNNEITYLgnSDLRGCVNLRALRLEANKINTIEE--DSFFPLGSLEHLDLSYNNISSLS 117
Cdd:cd21340   113 RSLAALSNSL----RVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 408-549 4.29e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 4.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 408 EILLTLKNLINlDISK--NGYLSMPETCQW-------PEKLKYLNLS----NTRIHSLTRCIPWtLEILDISNNNL---- 470
Cdd:PLN00113   32 ELLLSFKSSIN-DPLKylSNWNSSADVCLWqgitcnnSSRVVSIDLSgkniSGKISSAIFRLPY-IQTINLSNNQLsgpi 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045 471 -DSFSLTFPQLKELYISRNKLKTLPDASFLPMLQVMRISRNTVNTFSKEQLDSFQRLMTLEVGGNNF----------ICS 539
Cdd:PLN00113  110 pDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLvgkipnsltnLTS 189

                         170
                  ....*....|
gi 1702047045 540 CEFLSFTQEQ 549
Cdd:PLN00113  190 LEFLTLASNQ 199
LRR_8 pfam13855
Leucine rich repeat;
438-490 5.76e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 5.76e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1702047045 438 KLKYLNLSNTRIHSltrcIPWT-------LEILDISNNNLDSFSLT----FPQLKELYISRNKL 490
Cdd:pfam13855   2 NLRSLDLSNNRLTS----LDDGafkglsnLKVLDLSNNLLTTLSPGafsgLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 58-117 8.40e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 8.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702047045  58 LDLSNNEITYLGNsdLRGCVNLRALRLEA------------------------------NKINTIEEdsFFPLGSLEHLD 107
Cdd:cd21340    73 LYLGGNRISVVEG--LENLTNLEELHIENqrlppgekltfdprslaalsnslrvlnisgNNIDSLEP--LAPLRNLEQLD 148

                          90
                  ....*....|
gi 1702047045 108 LSYNNISSLS 117
Cdd:cd21340   149 ASNNQISDLE 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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