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Conserved domains on  [gi|1701944667|ref|NP_001358400|]
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polypeptide N-acetylgalactosaminyltransferase 11 isoform 6 [Homo sapiens]

Protein Classification

glycosyltransferase family protein( domain architecture ID 27718)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 154-238 3.38e-39

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd02510:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 299  Bit Score: 137.34  E-value: 3.38e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944667 154 SVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKYLPgKIKVIRNTKREGLIRGRMIGA 233
Cdd:cd02510     1 SVIIIFHNEALSTLLRTVHSVINRTPPELLKEIILVDDFSDKPELKLLLEEYYKKYLP-KVKVLRLKKREGLIRARIAGA 79


                  ....*
gi 1701944667 234 AHATG 238
Cdd:cd02510    80 RAATG 84
 
Name Accession Description Interval E-value
pp-GalNAc-T cd02510
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide ...
 154-238 3.38e-39

pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferases (pp-GalNAc-T) initiate the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to hydroxyl groups of Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-a-1-O-Ser/Thr). These enzymes are type II membrane proteins with a GT-A type catalytic domain and a lectin domain located on the lumen side of the Golgi apparatus. In human, there are 15 isozymes of pp-GalNAc-Ts, representing the largest of all glycosyltransferase families. Each isozyme has unique but partially redundant substrate specificity for glycosylation sites on acceptor proteins.


Pssm-ID: 133004 [Multi-domain]  Cd Length: 299  Bit Score: 137.34  E-value: 3.38e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944667 154 SVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKYLPgKIKVIRNTKREGLIRGRMIGA 233
Cdd:cd02510     1 SVIIIFHNEALSTLLRTVHSVINRTPPELLKEIILVDDFSDKPELKLLLEEYYKKYLP-KVKVLRLKKREGLIRARIAGA 79


                  ....*
gi 1701944667 234 AHATG 238
Cdd:cd02510    80 RAATG 84
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 154-238 3.82e-13

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 65.11  E-value: 3.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944667 154 SVVICFYNEAfSALLRTVHSVIDRTpaHLLHEIILVDDDSDFDdLKGELDEYVQKYlpGKIKVIRNTKREGLIRGRMIGA 233
Cdd:pfam00535   1 SVIIPTYNEE-KYLLETLESLLNQT--YPNFEIIVVDDGSTDG-TVEIAEEYAKKD--PRVRVIRLPENRGKAGARNAGL 74


                  ....*
gi 1701944667 234 AHATG 238
Cdd:pfam00535  75 RAATG 79
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
151-238 7.30e-06

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 45.37  E-value: 7.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944667 151 PAASVVICFYNEAfSALLRTVHSVIDRTPAHllHEIILVDDDSdfddlKGELDEYVQKYLPGKIKVIRNTKREGLIRGRM 230
Cdd:COG1216     3 PKVSVVIPTYNRP-ELLRRCLESLLAQTYPP--FEVIVVDNGS-----TDGTAELLAALAFPRVRVIRNPENLGFAAARN 74


                  ....*...
gi 1701944667 231 IGAAHATG 238
Cdd:COG1216    75 LGLRAAGG 82
 
Name Accession Description Interval E-value
pp-GalNAc-T cd02510
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide ...
 154-238 3.38e-39

pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferases (pp-GalNAc-T) initiate the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to hydroxyl groups of Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-a-1-O-Ser/Thr). These enzymes are type II membrane proteins with a GT-A type catalytic domain and a lectin domain located on the lumen side of the Golgi apparatus. In human, there are 15 isozymes of pp-GalNAc-Ts, representing the largest of all glycosyltransferase families. Each isozyme has unique but partially redundant substrate specificity for glycosylation sites on acceptor proteins.


Pssm-ID: 133004 [Multi-domain]  Cd Length: 299  Bit Score: 137.34  E-value: 3.38e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944667 154 SVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKYLPgKIKVIRNTKREGLIRGRMIGA 233
Cdd:cd02510     1 SVIIIFHNEALSTLLRTVHSVINRTPPELLKEIILVDDFSDKPELKLLLEEYYKKYLP-KVKVLRLKKREGLIRARIAGA 79


                  ....*
gi 1701944667 234 AHATG 238
Cdd:cd02510    80 RAATG 84
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 154-238 3.82e-13

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 65.11  E-value: 3.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944667 154 SVVICFYNEAfSALLRTVHSVIDRTpaHLLHEIILVDDDSDFDdLKGELDEYVQKYlpGKIKVIRNTKREGLIRGRMIGA 233
Cdd:pfam00535   1 SVIIPTYNEE-KYLLETLESLLNQT--YPNFEIIVVDDGSTDG-TVEIAEEYAKKD--PRVRVIRLPENRGKAGARNAGL 74


                  ....*
gi 1701944667 234 AHATG 238
Cdd:pfam00535  75 RAATG 79
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
151-238 7.30e-06

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 45.37  E-value: 7.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944667 151 PAASVVICFYNEAfSALLRTVHSVIDRTPAHllHEIILVDDDSdfddlKGELDEYVQKYLPGKIKVIRNTKREGLIRGRM 230
Cdd:COG1216     3 PKVSVVIPTYNRP-ELLRRCLESLLAQTYPP--FEVIVVDNGS-----TDGTAELLAALAFPRVRVIRNPENLGFAAARN 74


                  ....*...
gi 1701944667 231 IGAAHATG 238
Cdd:COG1216    75 LGLRAAGG 82
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 154-238 4.12e-05

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 43.15  E-value: 4.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944667 154 SVVICFYNEAfSALLRTVHSVIDRTPAHLlhEIILVdddsdfddlkgelD--------EYVQKYLPG--KIKVIRNTKRE 223
Cdd:COG0463     5 SVVIPTYNEE-EYLEEALESLLAQTYPDF--EIIVV-------------DdgstdgtaEILRELAAKdpRIRVIRLERNR 68

                          90
                  ....*....|....*
gi 1701944667 224 GLIRGRMIGAAHATG 238
Cdd:COG0463    69 GKGAARNAGLAAARG 83
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 147-238 1.42e-04

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 42.04  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1701944667 147 PPDLPAASVVICFYNEAfSALLRTVHSVIDRTPAHLLHEIILVDDDSdfddlKGELDEYVQKY--LPGKIKVIRNTKREG 224
Cdd:COG1215    25 PADLPRVSVIIPAYNEE-AVIEETLRSLLAQDYPKEKLEVIVVDDGS-----TDETAEIARELaaEYPRVRVIERPENGG 98

                          90
                  ....*....|....
gi 1701944667 225 LIRGRMIGAAHATG 238
Cdd:COG1215    99 KAAALNAGLKAARG 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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