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Conserved domains on  [gi|170045236|ref|XP_001850222|]
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protein D3 [Culex quinquefasciatus]

Protein Classification

YbhB/YbcL family Raf kinase inhibitor-like protein( domain architecture ID 10096268)

YbhB/YbcL family Raf kinase inhibitor-like protein similar to mammalian phosphatidylethanolamine-binding protein 1/2 and Schizosaccharomyces pombe mitochondrial 54S ribosomal protein L35

CATH:  3.90.280.10
SCOP:  4002457

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 47-190 1.96e-62

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


:

Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 191.05  E-value: 1.96e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170045236  47 KVTYPSGAEASLGNELTPTQVKDQPTVSWEADS--NSLYTLILTDPDAPSRANPKMREWRHWIVINIPGED-----VASG 119
Cdd:cd00866    4 TVSYGSSGVVTPGNLLTPSETQKAPTVSFSSEDppDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGSDtttglVSKG 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 170045236 120 EPVAEYISSAPPQGSGLHRYAFLVYKQPSGKIDFDEPRLNNRNPNRGMFRVAEFAAKYALGTPIAGNFYQA 190
Cdd:cd00866   84 EVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPESKLPPTSGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
 
Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 47-190 1.96e-62

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 191.05  E-value: 1.96e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170045236  47 KVTYPSGAEASLGNELTPTQVKDQPTVSWEADS--NSLYTLILTDPDAPSRANPKMREWRHWIVINIPGED-----VASG 119
Cdd:cd00866    4 TVSYGSSGVVTPGNLLTPSETQKAPTVSFSSEDppDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGSDtttglVSKG 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 170045236 120 EPVAEYISSAPPQGSGLHRYAFLVYKQPSGKIDFDEPRLNNRNPNRGMFRVAEFAAKYALGTPIAGNFYQA 190
Cdd:cd00866   84 EVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPESKLPPTSGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
PLN00169 PLN00169
CETS family protein; Provisional
 47-191 6.61e-26

CETS family protein; Provisional


Pssm-ID: 177765  Cd Length: 175  Bit Score: 98.34  E-value: 6.61e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170045236  47 KVTYpSGAEASLGNELTPTQVKDQPTVSWEA-DSNSLYTLILTDPDAPSRANPKMREWRHWIVINIPGEDVAS-GEPVAE 124
Cdd:PLN00169  29 RVTY-GSREVNNGCELKPSQVVNQPRVDIGGeDLRTFYTLVMVDPDAPSPSNPNLREYLHWLVTDIPATTGATfGQEVVC 107

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 170045236 125 YISSAPPqgSGLHRYAFLVYKQpSGKIDFDEPRLnnrnpnRGMFRVAEFAAKYALGTPIAGNFYQAQ 191
Cdd:PLN00169 108 YESPRPT--AGIHRFVFVLFRQ-LGRQTVYAPGW------RQNFNTRDFAELYNLGSPVAAVYFNCQ 165
PBP pfam01161
Phosphatidylethanolamine-binding protein;
70-187 7.86e-20

Phosphatidylethanolamine-binding protein;


Pssm-ID: 460090  Cd Length: 136  Bit Score: 81.23  E-value: 7.86e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170045236   70 QPTVSWEA--DSNSLYTLILTDPDAPSRANpkmREWRHWIVINIPGEDVASGEPV-------------AEYISSAPPQGS 134
Cdd:pfam01161  14 SPPLAWSGapAGTKSFALVMIDPDAPKVGG---SGWLHWVVTNIPATVTELPEGApagavqglndfggAGYGGPCPPAGD 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 170045236  135 GLHRYAFLVYKqpsgkidFDEPRLN-NRNPNRGMFRVAefAAKYALG-TPIAGNF 187
Cdd:pfam01161  91 GPHRYVFTLYA-------LDVPLLDrNWGFTKAELGVA--FAGHVLAlAVLAGNY 136
TIGR00481 TIGR00481
Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]
 71-157 3.03e-09

Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]


Pssm-ID: 129572  Cd Length: 141  Bit Score: 53.26  E-value: 3.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170045236   71 PTVSWE---ADSNSlYTLILTDPDAPSRANpkmreWRHWIVINIPG------EDVAS-------GEPVAE--------YI 126
Cdd:TIGR00481  16 PPLSWDgvpEGAKS-LALTCIDPDAPTGCG-----WWHWVVVNIPAdttvlpENASSddkrlpqGVPLQGrndfgksgYI 89

                          90       100       110
                  ....*....|....*....|....*....|.
gi 170045236  127 SSAPPqgSGLHRYAFLVYKQPSGKIDFDEPR 157
Cdd:TIGR00481  90 GPCPP--KGDHRYLFTVYALDTEKLDLDPGF 118
PEBP COG1881
Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family ...
 83-144 3.51e-09

Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family [General function prediction only];


Pssm-ID: 441485  Cd Length: 151  Bit Score: 53.24  E-value: 3.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170045236  83 YTLILTDPDAPSRANpkmreWRHWIVINIPG------EDVASGEPVAEYISS------------APPQGSGLHRYAFLVY 144
Cdd:COG1881   41 FALIVEDPDAPTGGG-----FWHWVVYNIPAdvtelpEGAGSADLPAGAVQGrndfgeagyggpCPPPGDGPHRYVFTVY 115
 
Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 47-190 1.96e-62

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 191.05  E-value: 1.96e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170045236  47 KVTYPSGAEASLGNELTPTQVKDQPTVSWEADS--NSLYTLILTDPDAPSRANPKMREWRHWIVINIPGED-----VASG 119
Cdd:cd00866    4 TVSYGSSGVVTPGNLLTPSETQKAPTVSFSSEDppDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGSDtttglVSKG 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 170045236 120 EPVAEYISSAPPQGSGLHRYAFLVYKQPSGKIDFDEPRLNNRNPNRGMFRVAEFAAKYALGTPIAGNFYQA 190
Cdd:cd00866   84 EVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPESKLPPTSGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
PLN00169 PLN00169
CETS family protein; Provisional
 47-191 6.61e-26

CETS family protein; Provisional


Pssm-ID: 177765  Cd Length: 175  Bit Score: 98.34  E-value: 6.61e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170045236  47 KVTYpSGAEASLGNELTPTQVKDQPTVSWEA-DSNSLYTLILTDPDAPSRANPKMREWRHWIVINIPGEDVAS-GEPVAE 124
Cdd:PLN00169  29 RVTY-GSREVNNGCELKPSQVVNQPRVDIGGeDLRTFYTLVMVDPDAPSPSNPNLREYLHWLVTDIPATTGATfGQEVVC 107

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 170045236 125 YISSAPPqgSGLHRYAFLVYKQpSGKIDFDEPRLnnrnpnRGMFRVAEFAAKYALGTPIAGNFYQAQ 191
Cdd:PLN00169 108 YESPRPT--AGIHRFVFVLFRQ-LGRQTVYAPGW------RQNFNTRDFAELYNLGSPVAAVYFNCQ 165
PEBP cd00457
PhosphatidylEthanolamine-Binding Protein (PEBP) domain; PhosphatidylEthanolamine-Binding ...
 50-190 3.74e-20

PhosphatidylEthanolamine-Binding Protein (PEBP) domain; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). A number of biological roles for members of the PEBP family include serine protease inhibition, membrane biogenesis, regulation of flowering plant stem architecture, and Raf-1 kinase inhibition. Although their overall structures are similar, the members of the PEBP family bind very different substrates including phospholipids, opioids, and hydrophobic odorant molecules as well as having different oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176642  Cd Length: 159  Bit Score: 82.83  E-value: 3.74e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170045236  50 YPSGAEasLGNELTPTQVKDQPTVSW--EADSNSLYTLILTDPDAPsranpKMREWRHWIVINIPG---------EDVAS 118
Cdd:cd00457    8 GPSGSV--LPPEYSFEGVGRFPSLSWdgPPPDVKEYVLVMEDPDAP-----LGRPIVHGLVYGIPAnktslsnddFVVTD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170045236 119 GEP--------------VAEYISSAPPQGSGLHRYAFLVYKQPSGKIDFDEPrlnnrnPNRGMFRVAEFAAKYALGtPIA 184
Cdd:cd00457   81 NGKgglqggfkygknrgGTVYIGPRPPLGHGPHRYFFQVYALDEPLDRSKLG------DGRTKFEVARFAEGNVLG-AVG 153


                 ....*.
gi 170045236 185 GNFYQA 190
Cdd:cd00457  154 EWVGQF 159
PBP pfam01161
Phosphatidylethanolamine-binding protein;
70-187 7.86e-20

Phosphatidylethanolamine-binding protein;


Pssm-ID: 460090  Cd Length: 136  Bit Score: 81.23  E-value: 7.86e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170045236   70 QPTVSWEA--DSNSLYTLILTDPDAPSRANpkmREWRHWIVINIPGEDVASGEPV-------------AEYISSAPPQGS 134
Cdd:pfam01161  14 SPPLAWSGapAGTKSFALVMIDPDAPKVGG---SGWLHWVVTNIPATVTELPEGApagavqglndfggAGYGGPCPPAGD 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 170045236  135 GLHRYAFLVYKqpsgkidFDEPRLN-NRNPNRGMFRVAefAAKYALG-TPIAGNF 187
Cdd:pfam01161  91 GPHRYVFTLYA-------LDVPLLDrNWGFTKAELGVA--FAGHVLAlAVLAGNY 136
TIGR00481 TIGR00481
Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]
 71-157 3.03e-09

Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]


Pssm-ID: 129572  Cd Length: 141  Bit Score: 53.26  E-value: 3.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170045236   71 PTVSWE---ADSNSlYTLILTDPDAPSRANpkmreWRHWIVINIPG------EDVAS-------GEPVAE--------YI 126
Cdd:TIGR00481  16 PPLSWDgvpEGAKS-LALTCIDPDAPTGCG-----WWHWVVVNIPAdttvlpENASSddkrlpqGVPLQGrndfgksgYI 89

                          90       100       110
                  ....*....|....*....|....*....|.
gi 170045236  127 SSAPPqgSGLHRYAFLVYKQPSGKIDFDEPR 157
Cdd:TIGR00481  90 GPCPP--KGDHRYLFTVYALDTEKLDLDPGF 118
PEBP COG1881
Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family ...
 83-144 3.51e-09

Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family [General function prediction only];


Pssm-ID: 441485  Cd Length: 151  Bit Score: 53.24  E-value: 3.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170045236  83 YTLILTDPDAPSRANpkmreWRHWIVINIPG------EDVASGEPVAEYISS------------APPQGSGLHRYAFLVY 144
Cdd:COG1881   41 FALIVEDPDAPTGGG-----FWHWVVYNIPAdvtelpEGAGSADLPAGAVQGrndfgeagyggpCPPPGDGPHRYVFTVY 115
PEBP_bact_arch cd00865
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; ...
 83-144 1.44e-06

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in bacterial and archaea. Members here include Escherichia coli YBHB and YBCL which are thought to regulate protein phosphorylation as well as Sulfolobus solfataricus SsCEI which inhibits serine proteases alpha-chymotrypsin and elastase. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer). In a few of the bacterial members present here the dimerization interface is proposed to form the ligand binding site, unlike in other PEBP members.


Pssm-ID: 176643  Cd Length: 150  Bit Score: 46.05  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170045236  83 YTLILTDPDAPSRanpkmREWRHWIVINIPG------EDVASGEPVAE------------YISSAPPQGsGLHRYAFLVY 144
Cdd:cd00865   42 LALIVEDPDAPTG-----GGFVHWVVWNIPAdttelpEGASRGALPAGavqgrndfgeagYGGPCPPDG-GPHRYVFTVY 115
PRK10257 PRK10257
putative kinase inhibitor protein; Provisional
 71-155 4.09e-06

putative kinase inhibitor protein; Provisional


Pssm-ID: 182339  Cd Length: 158  Bit Score: 45.15  E-value: 4.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170045236  71 PTVSWEADSNSLYTLILT--DPDAPSRANpkmreWRHWIVINIPG------EDVASGEP--------------VAEYISS 128
Cdd:PRK10257  32 PHLAWDDVPAGTKSFVVTcyDPDAPTGSG-----WWHWVVVNLPAdtrvlpQGFGSGLValpdgvlqtrtdfgKAGYGGA 106

                         90       100
                 ....*....|....*....|....*..
gi 170045236 129 APPQGSGlHRYAFLVYKQPSGKIDFDE 155
Cdd:PRK10257 107 APPKGET-HRYIFTVHALDVERIDVDE 132
PRK09818 PRK09818
kinase inhibitor;
43-154 3.35e-04

kinase inhibitor;


Pssm-ID: 182092  Cd Length: 183  Bit Score: 39.93  E-value: 3.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170045236  43 AMLAKVTYPSGAEA--------SLGNELTPTQV---------KDQPTVSWEADSNSLYTLILT--DPDAPSRANpkmreW 103
Cdd:PRK09818   8 SVLAFITFSAQAAAfqvtsneiKTGEQLTTSHVfsgfgceggNTSPSLTWSGAPEGTKSFAVTvyDPDAPTGSG-----W 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 170045236 104 RHWIVINIP----------GEDVASGEPV-----------AEYISSAPPQGSGLHRYAFLVYKQPSGKIDFD 154
Cdd:PRK09818  83 WHWTVANIPatvtylpadaGRRDGTKLPTgavqgrndfgyAGFGGACPPKGDKPHHYQFKVWALKTDKIPVD 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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