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Conserved domains on  [gi|1697699207|ref|NP_001358175|]
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sodium channel protein type 2 subunit alpha isoform 2 [Homo sapiens]

Protein Classification

sodium channel protein subunit alpha( domain architecture ID 11999295)

sodium channel protein subunit alpha is the ion conducting pore forming subunit of the channel that mediates the voltage-dependent sodium ion permeability of excitable membranes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
558-709 1.54e-91

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


:

Pssm-ID: 463401  Cd Length: 163  Bit Score: 293.95  E-value: 1.54e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  558 SLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHSTFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPI 637
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGSIFSFRGRGRDVGSENDFADDENSTFEDSESRRGSLFVPRRHLERRSSYQSQASRSSRSHPG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  638 LPMNGKMHSAVDCNGVVSLVGGPSTLTS-AGQLLPE----------GTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMS 706
Cdd:pfam11933   81 LPQNGKRHSTVDCNGVVSLVGGGPEPTSpGGQLLPEvildkpatgdSTTTEEELRKRRLSSYQLSMDYLEEPFQRQRAVS 160

                   ...
gi 1697699207  707 IAS 709
Cdd:pfam11933  161 AAS 163
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
997-1203 9.29e-84

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


:

Pssm-ID: 461936  Cd Length: 195  Bit Score: 273.06  E-value: 9.29e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  997 DNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKA-LDEIKPLEDLNNKKDSCISNHTTIEIGKDlnylkdgngtt 1075
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQLPkKKPLTELKDARSKLTNQIANHTSLKKAPG----------- 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1076 sgigssvEKYVVDEsDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESK-----EKLNATSSSEGSTVDIGA 1150
Cdd:pfam06512   70 -------GKYELDE-DHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQSSDEEKSkqqeqLEDDDSSSSEGSTVDLQD 141
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1697699207 1151 PAEG-EQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYK 1203
Cdd:pfam06512  142 PEEElEKIPEEAEELKEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1207-1482 2.47e-63

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 215.98  E-value: 2.47e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1207 HNWFETFIVFMILLSSGALAFEDIYIEQRKTiKTMLEYADKVFTYIFILEMLLKWVAYGFQV-YFTNAWCWLDFLIVDVS 1285
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPL-TTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1286 LVSLTANalGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH 1365
Cdd:pfam00520   80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1366 CINyttgemfdvsvvnnyseckaliesnqtarWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRnvelqpkyeD 1445
Cdd:pfam00520  158 WEN-----------------------------PDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK---------G 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1697699207 1446 NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1482
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1531-1786 1.01e-58

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 202.88  E-value: 1.01e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1531 QVFDISIMILICLNMVTMMVETDDQSQE-MTNILYWINLVFIVLFTGECVLKLISLR--YYYFTIGWNIFDFVVVILSIV 1607
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1608 GMFLAEliekyFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
Cdd:pfam00520   82 SLVLSS-----VGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1688 --EVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPpdcdpdkdhpgssvkgdcgnPSVGIFFFVSYIIISFL 1765
Cdd:pfam00520  157 twENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------------------EFWAYIYFVSFIILGGF 216
                          250       260
                   ....*....|....*....|.
gi 1697699207 1766 VVVNMYIAVILENFSVATEES 1786
Cdd:pfam00520  217 LLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
758-971 3.33e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 192.87  E-value: 3.33e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  758 DPFVDLAITICIVLNTLFMAMEHYPMTEQ-FSSVLSVGNLVFTGIFTAEMFLKIIAMDP-YYYFQEGWNIFDGFIVSLSL 835
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  836 MELGLANVE---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkecvc 912
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  913 KISNDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGN 971
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
128-435 2.52e-48

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 172.84  E-value: 2.52e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  128 HSLFNMLIMCTILTNCVFMTMSNPP-------DWTKNVEYTFTGIYTFESLIKILARGFCledFTFLRDPWNWLDFTVIT 200
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFqpeepltTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  201 FAYVT----EFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRN 276
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  277 kclqwppdnssfeinitsffnnsldgngttfnrtvsifnwdeyiedkshfyflegqndallcgnssdagqcpegyicvka 356
Cdd:pfam00520      --------------------------------------------------------------------------------
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  357 GRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQAT 435
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1474-1526 1.12e-31

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


:

Pssm-ID: 240441  Cd Length: 54  Bit Score: 118.44  E-value: 1.12e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1697699207 1474 DNFNQQKKKFGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFD 1526
Cdd:cd13433      1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
GPHH super family cl25190
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1798-1845 1.37e-03

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


The actual alignment was detected with superfamily member pfam16905:

Pssm-ID: 465306  Cd Length: 54  Bit Score: 38.40  E-value: 1.37e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1697699207 1798 FYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAK--PNKV---QLIAMDLP 1845
Cdd:pfam16905    2 FVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARVaykRLVRMNMP 54
 
Name Accession Description Interval E-value
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
558-709 1.54e-91

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 293.95  E-value: 1.54e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  558 SLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHSTFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPI 637
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGSIFSFRGRGRDVGSENDFADDENSTFEDSESRRGSLFVPRRHLERRSSYQSQASRSSRSHPG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  638 LPMNGKMHSAVDCNGVVSLVGGPSTLTS-AGQLLPE----------GTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMS 706
Cdd:pfam11933   81 LPQNGKRHSTVDCNGVVSLVGGGPEPTSpGGQLLPEvildkpatgdSTTTEEELRKRRLSSYQLSMDYLEEPFQRQRAVS 160

                   ...
gi 1697699207  707 IAS 709
Cdd:pfam11933  161 AAS 163
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
997-1203 9.29e-84

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 273.06  E-value: 9.29e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  997 DNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKA-LDEIKPLEDLNNKKDSCISNHTTIEIGKDlnylkdgngtt 1075
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQLPkKKPLTELKDARSKLTNQIANHTSLKKAPG----------- 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1076 sgigssvEKYVVDEsDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESK-----EKLNATSSSEGSTVDIGA 1150
Cdd:pfam06512   70 -------GKYELDE-DHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQSSDEEKSkqqeqLEDDDSSSSEGSTVDLQD 141
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1697699207 1151 PAEG-EQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYK 1203
Cdd:pfam06512  142 PEEElEKIPEEAEELKEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1207-1482 2.47e-63

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 215.98  E-value: 2.47e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1207 HNWFETFIVFMILLSSGALAFEDIYIEQRKTiKTMLEYADKVFTYIFILEMLLKWVAYGFQV-YFTNAWCWLDFLIVDVS 1285
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPL-TTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1286 LVSLTANalGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH 1365
Cdd:pfam00520   80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1366 CINyttgemfdvsvvnnyseckaliesnqtarWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRnvelqpkyeD 1445
Cdd:pfam00520  158 WEN-----------------------------PDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK---------G 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1697699207 1446 NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1482
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1531-1786 1.01e-58

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 202.88  E-value: 1.01e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1531 QVFDISIMILICLNMVTMMVETDDQSQE-MTNILYWINLVFIVLFTGECVLKLISLR--YYYFTIGWNIFDFVVVILSIV 1607
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1608 GMFLAEliekyFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
Cdd:pfam00520   82 SLVLSS-----VGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1688 --EVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPpdcdpdkdhpgssvkgdcgnPSVGIFFFVSYIIISFL 1765
Cdd:pfam00520  157 twENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------------------EFWAYIYFVSFIILGGF 216
                          250       260
                   ....*....|....*....|.
gi 1697699207 1766 VVVNMYIAVILENFSVATEES 1786
Cdd:pfam00520  217 LLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
758-971 3.33e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 192.87  E-value: 3.33e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  758 DPFVDLAITICIVLNTLFMAMEHYPMTEQ-FSSVLSVGNLVFTGIFTAEMFLKIIAMDP-YYYFQEGWNIFDGFIVSLSL 835
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  836 MELGLANVE---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkecvc 912
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  913 KISNDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGN 971
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
128-435 2.52e-48

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 172.84  E-value: 2.52e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  128 HSLFNMLIMCTILTNCVFMTMSNPP-------DWTKNVEYTFTGIYTFESLIKILARGFCledFTFLRDPWNWLDFTVIT 200
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFqpeepltTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  201 FAYVT----EFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRN 276
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  277 kclqwppdnssfeinitsffnnsldgngttfnrtvsifnwdeyiedkshfyflegqndallcgnssdagqcpegyicvka 356
Cdd:pfam00520      --------------------------------------------------------------------------------
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  357 GRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQAT 435
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1474-1526 1.12e-31

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 118.44  E-value: 1.12e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1697699207 1474 DNFNQQKKKFGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFD 1526
Cdd:cd13433      1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1798-1845 1.37e-03

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 38.40  E-value: 1.37e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1697699207 1798 FYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAK--PNKV---QLIAMDLP 1845
Cdd:pfam16905    2 FVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARVaykRLVRMNMP 54
ChtBD1_GH18_2 cd10909
Hevein or type 1 chitin binding domain (ChtBD1) subfamily; in some members co-occurs with ...
1713-1748 8.63e-03

Hevein or type 1 chitin binding domain (ChtBD1) subfamily; in some members co-occurs with family 18 glycosyl hydrolases; This subfamily includes a Toxoplasma gondii ME49 protein annotated as a putative mannosyl-oligosaccharide glucosidase. ChtBD1 is a lectin domain found in proteins from plants and fungi that bind N-acetylglucosamine, plant endochitinases, wound-induced proteins such as hevein, a major IgE-binding allergen in natural rubber latex, and the alpha subunit of Kluyveromyces lactis killer toxin. This domain is involved in the recognition and/or binding of chitin subunits; it typically occurs N-terminal to glycosyl hydrolase domains in chitinases, together with other carbohydrate-binding domains, or by itself in tandem-repeat arrangements.


Pssm-ID: 211315  Cd Length: 51  Bit Score: 36.20  E-value: 8.63e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1697699207 1713 SAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGN 1748
Cdd:cd10909      3 SDGRCGKGFPLLDGYPPVCDPDSEHPCCSNGGYCGS 38
 
Name Accession Description Interval E-value
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
558-709 1.54e-91

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 293.95  E-value: 1.54e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  558 SLLSIRGSLFSPRRNSRASLFSFRGRAKDIGSENDFADDEHSTFEDNDSRRDSLFVPHRHGERRHSNVSQASRASRVLPI 637
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGSIFSFRGRGRDVGSENDFADDENSTFEDSESRRGSLFVPRRHLERRSSYQSQASRSSRSHPG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  638 LPMNGKMHSAVDCNGVVSLVGGPSTLTS-AGQLLPE----------GTTTETEIRKRRSSSYHVSMDLLEDPTSRQRAMS 706
Cdd:pfam11933   81 LPQNGKRHSTVDCNGVVSLVGGGPEPTSpGGQLLPEvildkpatgdSTTTEEELRKRRLSSYQLSMDYLEEPFQRQRAVS 160

                   ...
gi 1697699207  707 IAS 709
Cdd:pfam11933  161 AAS 163
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
997-1203 9.29e-84

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 273.06  E-value: 9.29e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  997 DNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKA-LDEIKPLEDLNNKKDSCISNHTTIEIGKDlnylkdgngtt 1075
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQLPkKKPLTELKDARSKLTNQIANHTSLKKAPG----------- 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1076 sgigssvEKYVVDEsDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESK-----EKLNATSSSEGSTVDIGA 1150
Cdd:pfam06512   70 -------GKYELDE-DHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQSSDEEKSkqqeqLEDDDSSSSEGSTVDLQD 141
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1697699207 1151 PAEG-EQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYK 1203
Cdd:pfam06512  142 PEEElEKIPEEAEELKEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1207-1482 2.47e-63

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 215.98  E-value: 2.47e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1207 HNWFETFIVFMILLSSGALAFEDIYIEQRKTiKTMLEYADKVFTYIFILEMLLKWVAYGFQV-YFTNAWCWLDFLIVDVS 1285
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPL-TTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1286 LVSLTANalGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYH 1365
Cdd:pfam00520   80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1366 CINyttgemfdvsvvnnyseckaliesnqtarWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRnvelqpkyeD 1445
Cdd:pfam00520  158 WEN-----------------------------PDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK---------G 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1697699207 1446 NLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1482
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1531-1786 1.01e-58

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 202.88  E-value: 1.01e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1531 QVFDISIMILICLNMVTMMVETDDQSQE-MTNILYWINLVFIVLFTGECVLKLISLR--YYYFTIGWNIFDFVVVILSIV 1607
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1608 GMFLAEliekyFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKR 1687
Cdd:pfam00520   82 SLVLSS-----VGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1688 --EVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPpdcdpdkdhpgssvkgdcgnPSVGIFFFVSYIIISFL 1765
Cdd:pfam00520  157 twENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------------------EFWAYIYFVSFIILGGF 216
                          250       260
                   ....*....|....*....|.
gi 1697699207 1766 VVVNMYIAVILENFSVATEES 1786
Cdd:pfam00520  217 LLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
758-971 3.33e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 192.87  E-value: 3.33e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  758 DPFVDLAITICIVLNTLFMAMEHYPMTEQ-FSSVLSVGNLVFTGIFTAEMFLKIIAMDP-YYYFQEGWNIFDGFIVSLSL 835
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  836 MELGLANVE---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkecvc 912
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  913 KISNDCELPRWHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLTVFMMVMVIGN 971
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
128-435 2.52e-48

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 172.84  E-value: 2.52e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  128 HSLFNMLIMCTILTNCVFMTMSNPP-------DWTKNVEYTFTGIYTFESLIKILARGFCledFTFLRDPWNWLDFTVIT 200
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFqpeepltTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  201 FAYVT----EFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRN 276
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  277 kclqwppdnssfeinitsffnnsldgngttfnrtvsifnwdeyiedkshfyflegqndallcgnssdagqcpegyicvka 356
Cdd:pfam00520      --------------------------------------------------------------------------------
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207  357 GRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYM-IFFVLVIFLGSFYLINLILAVVAMAYEEQNQAT 435
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1474-1526 1.12e-31

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 118.44  E-value: 1.12e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1697699207 1474 DNFNQQKKKFGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFD 1526
Cdd:cd13433      1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1562-1780 3.04e-05

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 47.27  E-value: 3.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1562 ILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAelIEKYFVSPTLFRVI-----------RL 1630
Cdd:pfam08016   12 LCEIVFVVFFLYFVVEEILKIRKHRPSYLRSVWNLLDLAIVILSVVLIVLN--IYRDFLADRLIKSVeaspvtfidfdRV 89
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1631 ARIGRILRLIKG----------------AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAyvkrevgiDDM 1694
Cdd:pfam08016   90 AQLDNLYRIILAflvfltwlklfkvlrfNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG--------TQA 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1697699207 1695 FNFETFGNSMICLFQITTSA-GWDGLlapilnsgppdcdpdkdhpgssvkgDCGNPSVGIFFFVSYIIISFLVVVNMYIA 1773
Cdd:pfam08016  162 PNFSNFVKSILTLFRTILGDfGYNEI-------------------------FSGNRVLGPLLFLTFVFLVIFILLNLFLA 216

                   ....*..
gi 1697699207 1774 VILENFS 1780
Cdd:pfam08016  217 IINDSYV 223
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1798-1845 1.37e-03

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 38.40  E-value: 1.37e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1697699207 1798 FYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAK--PNKV---QLIAMDLP 1845
Cdd:pfam16905    2 FVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARVaykRLVRMNMP 54
ChtBD1_GH18_2 cd10909
Hevein or type 1 chitin binding domain (ChtBD1) subfamily; in some members co-occurs with ...
1713-1748 8.63e-03

Hevein or type 1 chitin binding domain (ChtBD1) subfamily; in some members co-occurs with family 18 glycosyl hydrolases; This subfamily includes a Toxoplasma gondii ME49 protein annotated as a putative mannosyl-oligosaccharide glucosidase. ChtBD1 is a lectin domain found in proteins from plants and fungi that bind N-acetylglucosamine, plant endochitinases, wound-induced proteins such as hevein, a major IgE-binding allergen in natural rubber latex, and the alpha subunit of Kluyveromyces lactis killer toxin. This domain is involved in the recognition and/or binding of chitin subunits; it typically occurs N-terminal to glycosyl hydrolase domains in chitinases, together with other carbohydrate-binding domains, or by itself in tandem-repeat arrangements.


Pssm-ID: 211315  Cd Length: 51  Bit Score: 36.20  E-value: 8.63e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1697699207 1713 SAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGN 1748
Cdd:cd10909      3 SDGRCGKGFPLLDGYPPVCDPDSEHPCCSNGGYCGS 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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