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Conserved domains on  [gi|169764565|ref|XP_001816754|]
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unnamed protein product [Aspergillus oryzae RIB40]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 50-492 1.62e-85

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17327:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 406  Bit Score: 270.66  E-value: 1.62e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  50 KLDFRIIPAFWVLYFLCAAVRSNVSLAQTMNIDTnhtifdVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPHVWM 129
Cdd:cd17327    1 KLDLFILPLLCILYFLQYLDKSNISNAAVMGMKE------DLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 130 SRIVISVGIIGTCMTAMKAAWSFYLLRLLLGIVIAGMWPGMAYYLTLFYPPSRTGKRIGQYYTAAQLSAAAVGLVSAGFQ 209
Cdd:cd17327   75 SVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVF 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 210 KMDGVRGYVGFQWMFLVWGVITIAVGILLLWWLPDRPTipgeqpakkkyLRWFprsppaLTGRDAEIHYHDLKRVYHRSA 289
Cdd:cd17327  155 KILGVGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPS-----------KAWF------LTEEEKELAVERLRANQTGKG 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 290 WT---LQDLLRVFLDWRLWPLLIMYFGVVGVGIGVQSYATVIIKAINPnlSGIDLSLLSAPIWLMDLAAILLVTPFSDRF 366
Cdd:cd17327  218 DQkfkWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGF--YSLQTNLLSVPIGALGAVSLLIAALLSDRF 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 367 hHHRAVFFSVPVLLQILGLLLTTYAgtdTNSWPRYGGLLIVGFGLGPTVPITMTWTTEIFqprHGEVGVAAASAVVSGLG 446
Cdd:cd17327  296 -KKRGLFAIFACVLALVGSIILLAA---PNPPGAYFAAYILGGGSYAGFPILLSWISSNC---AGYTKRATVLAIMLIFY 368

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 169764565 447 NLGSIVTTYALYNGwaedsAAPgrlKFRKSNLVMVGILCGSILAAV 492
Cdd:cd17327  369 NVGNIVAPQIFRAG-----DAP---RYIPGNIALLVCACVSIVLSV 406
 
Name Accession Description Interval E-value
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 50-492 1.62e-85

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 270.66  E-value: 1.62e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  50 KLDFRIIPAFWVLYFLCAAVRSNVSLAQTMNIDTnhtifdVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPHVWM 129
Cdd:cd17327    1 KLDLFILPLLCILYFLQYLDKSNISNAAVMGMKE------DLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 130 SRIVISVGIIGTCMTAMKAAWSFYLLRLLLGIVIAGMWPGMAYYLTLFYPPSRTGKRIGQYYTAAQLSAAAVGLVSAGFQ 209
Cdd:cd17327   75 SVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVF 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 210 KMDGVRGYVGFQWMFLVWGVITIAVGILLLWWLPDRPTipgeqpakkkyLRWFprsppaLTGRDAEIHYHDLKRVYHRSA 289
Cdd:cd17327  155 KILGVGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPS-----------KAWF------LTEEEKELAVERLRANQTGKG 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 290 WT---LQDLLRVFLDWRLWPLLIMYFGVVGVGIGVQSYATVIIKAINPnlSGIDLSLLSAPIWLMDLAAILLVTPFSDRF 366
Cdd:cd17327  218 DQkfkWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGF--YSLQTNLLSVPIGALGAVSLLIAALLSDRF 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 367 hHHRAVFFSVPVLLQILGLLLTTYAgtdTNSWPRYGGLLIVGFGLGPTVPITMTWTTEIFqprHGEVGVAAASAVVSGLG 446
Cdd:cd17327  296 -KKRGLFAIFACVLALVGSIILLAA---PNPPGAYFAAYILGGGSYAGFPILLSWISSNC---AGYTKRATVLAIMLIFY 368

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 169764565 447 NLGSIVTTYALYNGwaedsAAPgrlKFRKSNLVMVGILCGSILAAV 492
Cdd:cd17327  369 NVGNIVAPQIFRAG-----DAP---RYIPGNIALLVCACVSIVLSV 406
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
45-499 6.91e-26

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 109.19  E-value: 6.91e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  45 ERIYRKLDFRIIPAFWVLYFLCAAVRSNVSLAQTmnidtnhTIFDVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLS 124
Cdd:COG2271    1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAP-------PLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 125 PHVWMSRIVISVGIIGTCMTAMKAAWSFYLLRLLLGIVIAGMWPGMAYYLTLFYPPSRTGKRIGQYYTAAQLSAAAVGLV 204
Cdd:COG2271   74 RRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 205 SAGFQkmdgvrGYVGFQWMFLVWGVITIAVGILllwwlpdrptipgeqpakkkylrwfprsppaltgrdaeihyhdlkrv 284
Cdd:COG2271  154 LGWLL------AAFGWRAAFLILGLPGLLLALL----------------------------------------------- 180

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 285 yhrsawtlqdllrvfldwRLWPLLIMYFGVVGVGIGVQSYATVIIKAINpNLSGIDLSLLSAPIWLMDLAAILLVTPFSD 364
Cdd:COG2271  181 ------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVR-GLSLAQAGLLLSLPFLAGIVGSLLGGWLSD 241

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 365 RFHHHRAVFFSVPVLLQILGLLLTTYAGtdtNSWPRYGGLLIVGFGLGPTVPITMTWTTEIFQPRHgevgVAAASAVVSG 444
Cdd:COG2271  242 RLGRRRKLVLAIGLLLAALALLLLALLP---SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKA----RGTASGLVNT 314

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 169764565 445 LGNLGSIVTTYALynGWAEDSAAPgrlkfrksNLVMVGILCGSILAAVLMQILVR 499
Cdd:COG2271  315 FGFLGGALGPLLV--GYLLDATGY--------QAAFLLLAALALLAALLALLLLR 359
MFS_1 pfam07690
Major Facilitator Superfamily;
59-430 5.17e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 91.33  E-value: 5.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565   59 FWVLYFLCAAVRSNVSLAQTMnidtnhTIFDVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPHVWMSRIVISVGI 138
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPL------LLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  139 IGTCMTAMKAAWSFYLLRLLLGIVIAGMWPGMAYYLTLFYPPSRTGKRIGQYYTAAQLsAAAVGLVSAGFqkmdgVRGYV 218
Cdd:pfam07690  75 GLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGL-GAALGPLLGGL-----LASLF 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  219 GFQWMFLVWGVITIAVGIllLWWLPDRPTIPGEQPAKKKYLRWFPRsppaltgrdaeihyhdlkrvyhrsawtlqdLLRV 298
Cdd:pfam07690 149 GWRAAFLILAILSLLAAV--LLLLPRPPPESKRPKPAEEARLSLIV------------------------------AWKA 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  299 FLDWRLWPLLIMYFGVVGVGIGVQSYATVIIKAInpNLSGIDLSLLSAPIWLMDLAAILLVTPFSDRFHHHRAVFFSVPV 378
Cdd:pfam07690 197 LLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL--GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLL 274

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 169764565  379 LLQILGLLltTYAGTDTNSWPRYGGLLIVGFGLGPTVPITMTWTTEIFQPRH 430
Cdd:pfam07690 275 LILAALGL--LLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEE 324
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 60-254 5.13e-08

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 55.07  E-value: 5.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565   60 WVLYFLCAAVRSNVSLAQTMnidtnhtIFDVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPHVWMSRIVISVGII 139
Cdd:TIGR00881   1 FIGYAAYYLVRKNFALAMPY-------LVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  140 GTCMTAMKAAWSFYLLRLLLGIVIAGMWPGMAYYLTLFYPPSRTGKRIGQYYTAAQLSAAAV-GLVSAGFQKMdgvrgyV 218
Cdd:TIGR00881  74 NLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLpPLVLFGIAEL------Y 147

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 169764565  219 GFQWMFLVWGVITIAVGILLLWWLPDRPTIPGEQPA 254
Cdd:TIGR00881 148 SWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPA 183
PRK11663 PRK11663
glucose-6-phosphate receptor/MFS transporter UhpC;
104-250 4.98e-07

glucose-6-phosphate receptor/MFS transporter UhpC;


Pssm-ID: 183266 [Multi-domain]  Cd Length: 434  Bit Score: 52.02  E-value: 4.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 104 LFYVCYVVFDLPSNLIMSRLSPHVWMSRIVISVGIIGTCMTAMKAAWSFYLLRLLLGIVIAGMWPGMAYYLTLFYPPSRT 183
Cdd:PRK11663  66 LFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTER 145

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 169764565 184 GKRIGQYYTAAQLSAAAVGLVsAGFQKMdgvrgYVGFQWMFLVWGVITIAVGILLLWWLPDRPTIPG 250
Cdd:PRK11663 146 GGWWAIWNTAHNVGGALIPLV-VGAIAL-----HYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMG 206
 
Name Accession Description Interval E-value
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 50-492 1.62e-85

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 270.66  E-value: 1.62e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  50 KLDFRIIPAFWVLYFLCAAVRSNVSLAQTMNIDTnhtifdVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPHVWM 129
Cdd:cd17327    1 KLDLFILPLLCILYFLQYLDKSNISNAAVMGMKE------DLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 130 SRIVISVGIIGTCMTAMKAAWSFYLLRLLLGIVIAGMWPGMAYYLTLFYPPSRTGKRIGQYYTAAQLSAAAVGLVSAGFQ 209
Cdd:cd17327   75 SVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVF 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 210 KMDGVRGYVGFQWMFLVWGVITIAVGILLLWWLPDRPTipgeqpakkkyLRWFprsppaLTGRDAEIHYHDLKRVYHRSA 289
Cdd:cd17327  155 KILGVGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPS-----------KAWF------LTEEEKELAVERLRANQTGKG 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 290 WT---LQDLLRVFLDWRLWPLLIMYFGVVGVGIGVQSYATVIIKAINPnlSGIDLSLLSAPIWLMDLAAILLVTPFSDRF 366
Cdd:cd17327  218 DQkfkWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGF--YSLQTNLLSVPIGALGAVSLLIAALLSDRF 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 367 hHHRAVFFSVPVLLQILGLLLTTYAgtdTNSWPRYGGLLIVGFGLGPTVPITMTWTTEIFqprHGEVGVAAASAVVSGLG 446
Cdd:cd17327  296 -KKRGLFAIFACVLALVGSIILLAA---PNPPGAYFAAYILGGGSYAGFPILLSWISSNC---AGYTKRATVLAIMLIFY 368

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 169764565 447 NLGSIVTTYALYNGwaedsAAPgrlKFRKSNLVMVGILCGSILAAV 492
Cdd:cd17327  369 NVGNIVAPQIFRAG-----DAP---RYIPGNIALLVCACVSIVLSV 406
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 53-456 1.24e-26

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 111.12  E-value: 1.24e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  53 FRIIPAFWVLYFLCAAVRSNVSLAQ-TMNIDtnhtifdvLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPHVWMSR 131
Cdd:cd17319    2 WRIIPLLFLAYVINYLDRVNISVAApTIMKD--------LGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAV 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 132 IVISVGIIGTCMTAMKAAWSFYLLRLLLGIVIAGMWPGMAYYLTLFYPPSRTGKRIGQYYTAAQLSAAAVGLVSAGFQkm 211
Cdd:cd17319   74 SMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL-- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 212 dgvrGYVGFQWMFLVWGVITIAVGILLLWWLPdrptipgeqpakkkylrwfprsppaltgrdaeihyhdlkrvyhrsawt 291
Cdd:cd17319  152 ----LLFGWRWAFIIEGLLGLLLAVLWWFYLR------------------------------------------------ 179

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 292 lqdllrvfldwRLWPLLIMYFGVVGVGIGVQSYATVIIKAiNPNLSGIDLSLLSAPIWLMDLAAILLVTPFSDRFHHH-R 370
Cdd:cd17319  180 -----------QVWGLALGYFGINYALYGLLTWLPTYLKQ-ARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGaR 247

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 371 AVFFSVPVLLQILGLLLttyAGTDTNSWPRYGGLLIVGFGLGPTVPITMTWTTEIFQPRHgevgVAAASAVVSGLGNLGS 450
Cdd:cd17319  248 RLVIIIGLLLAAVGLLL---AYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEA----AATAGGLINSGGNLGG 320


                 ....*.
gi 169764565 451 IVTTYA 456
Cdd:cd17319  321 FVAPLL 326
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
45-499 6.91e-26

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 109.19  E-value: 6.91e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  45 ERIYRKLDFRIIPAFWVLYFLCAAVRSNVSLAQTmnidtnhTIFDVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLS 124
Cdd:COG2271    1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAP-------PLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 125 PHVWMSRIVISVGIIGTCMTAMKAAWSFYLLRLLLGIVIAGMWPGMAYYLTLFYPPSRTGKRIGQYYTAAQLSAAAVGLV 204
Cdd:COG2271   74 RRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 205 SAGFQkmdgvrGYVGFQWMFLVWGVITIAVGILllwwlpdrptipgeqpakkkylrwfprsppaltgrdaeihyhdlkrv 284
Cdd:COG2271  154 LGWLL------AAFGWRAAFLILGLPGLLLALL----------------------------------------------- 180

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 285 yhrsawtlqdllrvfldwRLWPLLIMYFGVVGVGIGVQSYATVIIKAINpNLSGIDLSLLSAPIWLMDLAAILLVTPFSD 364
Cdd:COG2271  181 ------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVR-GLSLAQAGLLLSLPFLAGIVGSLLGGWLSD 241

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 365 RFHHHRAVFFSVPVLLQILGLLLTTYAGtdtNSWPRYGGLLIVGFGLGPTVPITMTWTTEIFQPRHgevgVAAASAVVSG 444
Cdd:COG2271  242 RLGRRRKLVLAIGLLLAALALLLLALLP---SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKA----RGTASGLVNT 314

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 169764565 445 LGNLGSIVTTYALynGWAEDSAAPgrlkfrksNLVMVGILCGSILAAVLMQILVR 499
Cdd:COG2271  315 FGFLGGALGPLLV--GYLLDATGY--------QAAFLLLAALALLAALLALLLLR 359
MFS_1 pfam07690
Major Facilitator Superfamily;
59-430 5.17e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 91.33  E-value: 5.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565   59 FWVLYFLCAAVRSNVSLAQTMnidtnhTIFDVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPHVWMSRIVISVGI 138
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPL------LLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  139 IGTCMTAMKAAWSFYLLRLLLGIVIAGMWPGMAYYLTLFYPPSRTGKRIGQYYTAAQLsAAAVGLVSAGFqkmdgVRGYV 218
Cdd:pfam07690  75 GLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGL-GAALGPLLGGL-----LASLF 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  219 GFQWMFLVWGVITIAVGIllLWWLPDRPTIPGEQPAKKKYLRWFPRsppaltgrdaeihyhdlkrvyhrsawtlqdLLRV 298
Cdd:pfam07690 149 GWRAAFLILAILSLLAAV--LLLLPRPPPESKRPKPAEEARLSLIV------------------------------AWKA 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  299 FLDWRLWPLLIMYFGVVGVGIGVQSYATVIIKAInpNLSGIDLSLLSAPIWLMDLAAILLVTPFSDRFHHHRAVFFSVPV 378
Cdd:pfam07690 197 LLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL--GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLL 274

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 169764565  379 LLQILGLLltTYAGTDTNSWPRYGGLLIVGFGLGPTVPITMTWTTEIFQPRH 430
Cdd:pfam07690 275 LILAALGL--LLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEE 324
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
54-430 6.56e-20

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 91.87  E-value: 6.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  54 RIIPAFWVLYFLCAAVRSNVSLAQTmnidtnhTIFDVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPHVWMSRIV 133
Cdd:COG2223    5 RVLLLATLAFFLAFGVWYLWSVLAP-------PLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 134 ISVGIIGTCMTAMKAAWSFYLLRLLLGIVIAGMWPGMAYYLTLFYPPSRTGKRIGQYYTAAQLSAAAVGLVSAgfqkmdG 213
Cdd:COG2223   78 LLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAP------L 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 214 VRGYVGFQWMFLVWGVITIAVGILLLWWLPDRPtiPGEQPAKKKylrwfprsppaltgrdaeihyhdlkrvyhrsawTLQ 293
Cdd:COG2223  152 LIAAFGWRNAFLILGILLLVVAVLAWLFLRDPP--AGAAAAAKA---------------------------------SLR 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 294 DLLRVFLDWRLWPLLIMYFGVVGVGIGVQSYATVIIKAINPnLSGIDLSLLSAPIWLMDLAAILLVTPFSDRFHHHRAVF 373
Cdd:COG2223  197 DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFG-LSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLL 275

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 169764565 374 FSVPVLLQILGLLlttyAGTDTNSWPRYGGLLIVGFGLGPTVPITMTWTTEIFQPRH 430
Cdd:COG2223  276 IVFALMALGLLLL----ALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKN 328
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 59-430 1.35e-17

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 84.79  E-value: 1.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  59 FWVLYFLCAAVRSNVSLAQTMnidtnhtIFDVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPHVWM--SRIVISV 136
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPA-------LLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLllGLLLFAL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 137 GIIGtcMTAMKAAWSFYLLRLLLGIVIAGMWPGMAYYLTLFYPPSRTGKRIGQYYTAAQLSAAAVGLVSAGFqkmdGVRG 216
Cdd:cd06174   74 GALL--FAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIL----ASSL 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 217 YVGFQWMFLVWGVITIAVGILLLWWLPDRPTIPGEQPAKKKYLRWFprsppaltgrdaeihyhdlkrvyhrsawtlQDLL 296
Cdd:cd06174  148 GFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVL------------------------------KLLK 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 297 RVFLDWRLWPLLIMYFGVVGVGIGVQSYATVIIKAINpNLSGIDLSLLSAPIWLMDLAAILLVTPFSDRFHHHRAVFfsv 376
Cdd:cd06174  198 RVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG-GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLL--- 273

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 169764565 377 pVLLQILGLLLTTYAGTDTNSWPRYGGLLIVGFGLGPTVPITMTWTTEIFQPRH 430
Cdd:cd06174  274 -LIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEI 326
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
60-430 2.39e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 83.48  E-value: 2.39e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  60 WVLYFLCAAVRSNVSLAQTMNIDTNHTIFDVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPhvwmsRIVISVGII 139
Cdd:COG2814    9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGR-----RRVLLLGLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 140 GTCMTAMKAA-----WSFYLLRLLLGIVIAGMWPGMAYYLTLFYPPSRTGKRIGqYYTAAQLSAAAVGLVSAGFqkmdgV 214
Cdd:COG2814   84 LFALGSLLCAlapslWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALG-LLGAGLGLGPALGPLLGGL-----L 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 215 RGYVGFQWMFLVWGVITIAVGILLLWWLPDRPtipgeqpakkkylrwfPRSPPALTGRdaeihyhdlkrvyhrsawtlqd 294
Cdd:COG2814  158 ADLFGWRWVFLVNAVLALLALLLLLRLLPESR----------------PAARARLRGS---------------------- 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 295 LLRVFLDWRLWPLLIMYFGVVGVGIGVQSYATVIIKAINpNLSGIDLSLLSAPIWLMDLAAILLVTPFSDRFHHHRAVFF 374
Cdd:COG2814  200 LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL-GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLI 278

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 169764565 375 SVPVLLQILGLLLTTyagtdTNSWPRYGGLLIVGFGLGPTVPITMTWTTEIFQPRH 430
Cdd:COG2814  279 GLLLLALGLLLLALA-----GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEA 329
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 91-269 3.58e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 61.82  E-value: 3.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  91 LHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSpHVWMsrIVISVGIIGTCMTAMKAA---WSFYLLRLLLGIVIAGMW 167
Cdd:cd17325   26 LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFG-RKRL--LLLGLLLLAVSTLLFAFAtsyWQLLLARFLQGLASAAVW 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 168 PGMAYYLTLFYPPSRTGKRIGqYYTAAQLSAAAVGLVSAGFqkmdgVRGYVGFQWMFLVWGVITIAVGILLLWWLPDRPT 247
Cdd:cd17325  103 PAAMALIADIAPPEERGRAMG-IFSSAIGLGFLIGPLLGGL-----LADALGYRAPFLVCAALALLALVLALLLLPEPRP 176

                        170       180
                 ....*....|....*....|....*
gi 169764565 248 IP---GEQPAKKKYLRWFPRSPPAL 269
Cdd:cd17325  177 PPnkrAVSAARLRSGLRLLLRDRRL 201
MFS_UhpC cd17488
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ...
 104-246 3.37e-08

Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341041 [Multi-domain]  Cd Length: 364  Bit Score: 55.49  E-value: 3.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 104 LFYVCYVVFDLPSNLIMSRLSPHVWMSRIVISVGIIGTCMTAMKAAWSFYLLRLLLGIVIAGMWPGMAYYLTLFYPPSRT 183
Cdd:cd17488   46 LFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNER 125

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 169764565 184 GKRIGQYYTAAQLSAAAVGLVSAGfqkmdgVRGYVGFQWMFLVWGVITIAVGILLLWWLPDRP 246
Cdd:cd17488  126 GFWWSIWNTSHNIGGALIPILTGF------AALTYGWRAGMYVPGIIAILMGIVLCWRLRDRP 182
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 60-254 5.13e-08

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 55.07  E-value: 5.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565   60 WVLYFLCAAVRSNVSLAQTMnidtnhtIFDVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPHVWMSRIVISVGII 139
Cdd:TIGR00881   1 FIGYAAYYLVRKNFALAMPY-------LVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  140 GTCMTAMKAAWSFYLLRLLLGIVIAGMWPGMAYYLTLFYPPSRTGKRIGQYYTAAQLSAAAV-GLVSAGFQKMdgvrgyV 218
Cdd:TIGR00881  74 NLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLpPLVLFGIAEL------Y 147

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 169764565  219 GFQWMFLVWGVITIAVGILLLWWLPDRPTIPGEQPA 254
Cdd:TIGR00881 148 SWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPA 183
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 91-269 9.12e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 54.09  E-value: 9.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  91 LHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPHVWMSrIVISVGIIGTCMTAMkaAWSFYLL---RLLLGIVIAGMW 167
Cdd:cd17324   29 FGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLL-VLLLLFILGNLLAAL--APSFALLllaRALAGLAHGGFW 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 168 PGMAYYLTLFYPPSRTGKRIGQYYTAAQLsAAAVGLVSAGFqkmdgVRGYVGFQWMFLVWGVITIAVGILLLWWLPDRPT 247
Cdd:cd17324  106 AIAAAYAADLVPPEKRGRAIGLVFSGLTL-GLVLGRPLGGL-----LGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPP 179

                        170       180
                 ....*....|....*....|..
gi 169764565 248 IPGEQPAKKKYLRWFPRSPPAL 269
Cdd:cd17324  180 KKPGSLGLLSSLLLLLRNPRLR 201
PRK11663 PRK11663
glucose-6-phosphate receptor/MFS transporter UhpC;
104-250 4.98e-07

glucose-6-phosphate receptor/MFS transporter UhpC;


Pssm-ID: 183266 [Multi-domain]  Cd Length: 434  Bit Score: 52.02  E-value: 4.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 104 LFYVCYVVFDLPSNLIMSRLSPHVWMSRIVISVGIIGTCMTAMKAAWSFYLLRLLLGIVIAGMWPGMAYYLTLFYPPSRT 183
Cdd:PRK11663  66 LFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTER 145

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 169764565 184 GKRIGQYYTAAQLSAAAVGLVsAGFQKMdgvrgYVGFQWMFLVWGVITIAVGILLLWWLPDRPTIPG 250
Cdd:PRK11663 146 GGWWAIWNTAHNVGGALIPLV-VGAIAL-----HYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMG 206
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 89-242 1.22e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 50.65  E-value: 1.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  89 DVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPHVWMSRIVISVGIIGTCMTAMKAAWSFYLLRLLLGIVIAGMWP 168
Cdd:cd17325  228 ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFP 307

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 169764565 169 GMAYYLTLFYPPSRTGKRIGQYYTAAQLsAAAVGLVSAGFqkmdgVRGYVGFQWMFLVWGVITIAVGILLLWWL 242
Cdd:cd17325  308 ATLALLADIVPPEGRGTAMGLFNTAFSL-GMVLGPLLGGF-----LYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 91-257 1.32e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 50.67  E-value: 1.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  91 LHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPhvwmsRIVISVGIIGTCMTAM-----KAAWSFYLLRLLLGIVIAG 165
Cdd:cd17489   26 LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGR-----KRLLLIGLLIFALATLlyllaTSVALLLVLRLIHGIGWGA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 166 MWPGMAYYLTLFYPPSRTGKRIGqYYTAAQLSAAAVGLVSAGFqkmdgVRGYVGFQWMFLVwGVITIAVGILLLWWLPDR 245
Cdd:cd17489  101 FTTAAATLVADIIPPSRRGEGIG-YYGLATTLAMALGPALGLF-----LYQHLGFAVLFIV-AAVLALLALLLVFLVKDP 173

                        170
                 ....*....|..
gi 169764565 246 PTIPGEQPAKKK 257
Cdd:cd17489  174 PPVAAEEAEAGT 185
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 97-246 1.69e-06

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 50.35  E-value: 1.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  97 QVSTALALFYVCYVVFDLPSNLIMSRLSPHVWMSRIVISVGIIGTCMTAMKAAWSFYLLRLLLGIVIAGMWPGMAYYLTL 176
Cdd:cd17312   39 DLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGN 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 177 FYPPSRTGKRIGQYYTAAQLSAAAVGLVSAGfqkmdgVRGYVGFQWMFLVWGVITIAVGILLLWWLPDRP 246
Cdd:cd17312  119 WFSKKERGTVYGIWSTSHNFGGILAPILAAS------LASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP 182
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 86-271 7.19e-06

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 47.88  E-value: 7.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  86 TIFDVLHVNDHQVSTALALFYVCYVVFdlpsNLIMSRLSphvwmSRI------VISVGIIGTCMTAMKAAWSFYLL---R 156
Cdd:COG0477   39 SIAADLGASSAQLGWIVSAYLLGRAIG----LLLFGRLG-----DRYgrkrvlLIGLLLFGLASLLCGLAPSPELLiaaR 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 157 LLLGIVIAGMWPGMAYYLTLFYPPSRTGKRIGqYYTAAQLSAAAVGLVSAGFqkmdgVRGYVGFQWMFLVWGVITIAVGI 236
Cdd:COG0477  110 ALQGIGAGGLMPGALALIAELFPARERGRALG-LWGAAIGLGLALGPLLGGL-----LVAALGWRWIFLINAPLGLLALV 183

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 169764565 237 LLLWWLPDRPTIPGEQPAKKKYLRWFPRSPPALTG 271
Cdd:COG0477  184 LRLRLPESRGLLLALLALALAALLLAALALALLAL 218
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
89-246 1.09e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 47.56  E-value: 1.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  89 DVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPHVWMSrIVISVGIIGTCMTAMKAA---WSFYLLRLLLGIVIAG 165
Cdd:COG2271  209 EVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLV-LAIGLLLAALALLLLALLpspALAIALLFLAGFGLGG 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 166 MWPGMAYYLTLFYPPSRTGKRIGQYYTAAQLSAAAVGLVsAGFqkmdgVRGYVGFQWMFLVWGVITIAVGILLLWWLPDR 245
Cdd:COG2271  288 AFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLL-VGY-----LLDATGYQAAFLLLAALALLAALLALLLLRET 361


                 .
gi 169764565 246 P 246
Cdd:COG2271  362 R 362
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
91-431 3.46e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 46.40  E-value: 3.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  91 LHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPH--VWMSRIVISVGIIGtcMTAMKAAWSFYLLRLLLGIVIAGMWP 168
Cdd:COG2807   48 LGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLErtLLLALLLLAAGLLL--RSLAPSVALLLAGTALIGAGIAVGNV 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 169 GMAYYLTLFYPpSRTGKRIGQYYTAAQLSAAAVGLVSAGfqkmdgVRGYVGFQWMFLVWGVITIAVGILLLWWLPDRPTI 248
Cdd:COG2807  126 LLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVP------LAAALGWRGALAVWALLALLALLLWLPLLRRRPAA 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 249 PGEQPAkkkylrwfprsppaltgrdaeihyhdlkrvyhrsAWTLQDLLRvflDWRLWPLLIMYFGVVGVGIGVQSYATVI 328
Cdd:COG2807  199 AAAAPA----------------------------------AASLRSLWR---SPLAWLLTLFFGLQSLLYYAVVAWLPPI 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 329 IKA--INPNLSGIDLSLLSapiwLMDLAAILLVTPFSDRFHHHRAVFFSVPVllqilgLLLTTYAG--TDTNSWPrYGGL 404
Cdd:COG2807  242 LRDagLSAATAGLLLSLFQ----LAGIPGSLLVPLLADRLGDRRPLLLLLGL------LGLAGLLGllLAPGSLP-WLWA 310

                        330       340
                 ....*....|....*....|....*..
gi 169764565 405 LIVGFGLGPTVPITMTWTTEIFQPRHG 431
Cdd:COG2807  311 VLLGLGQGGLFPLALTLIGLRARTPAE 337
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 69-247 9.25e-05

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 44.93  E-value: 9.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  69 VRSNVSLAQtmnidtnHTIFDVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPHVWMSRIVISVGIIGTCMTAMKA 148
Cdd:cd17345   18 VRNNFSLAQ-------PYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPS 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 149 A----WSFYLLRLLLGIViAGM-WPGMAYYLTLFYPPSRTGKRIGQYYTAAQLSAAAVGLVsAGFqkMDGVRGYVGFQWM 223
Cdd:cd17345   91 AtssvGLMFILLFLNGWF-QGMgWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPL-AGL--GLAIFGDGWWRGA 166

                        170       180
                 ....*....|....*....|....
gi 169764565 224 FLVWGVITIAVGILLLWWLPDRPT 247
Cdd:cd17345  167 FIFPAIIAIIVAVIVLFLGKDTPE 190
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 128-247 9.30e-05

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 44.93  E-value: 9.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 128 WMSRIVISVGIIGT--CMTAMKAAWSFYLLRLLLGIVIAGMWPGMaYYLTLFYPPSRTGKRIGQYYTAAQLSAAAVGLVS 205
Cdd:cd17341   65 RVFIASLLLLLIPLlaLALAVSSYWGLLVLGFLLGFAGANFASGQ-PWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLA 143

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 169764565 206 AG-FQKMDGVRGYVGFQWMFLVWGVITIAVGILLLWWLPDRPT 247
Cdd:cd17341  144 PLiAGAIVFDGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLPT 186
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
89-431 1.97e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 43.69  E-value: 1.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  89 DVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSphvwmSRIVISVGIIGTC-----MTAMKAAWSFYLLRLLLGIVI 163
Cdd:COG0738   36 DAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFG-----YKRGLLLGLLLMAlglllFALAPSYPLLLLALFLLGLGL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 164 AGMWPGMAYYLTLFYPPSRTgKRIGQYYTAAQLSAAAVGLVSAGFQKMDGVrgyVGFQWMFLVWGVITIAVGILLLWW-L 242
Cdd:COG0738  111 GLLDVAANPYVAALGPETAA-SRLNLLHAFFSLGALLGPLLGGLLILLGLS---LSWHLPYLILAVLLLLLALLFLRSkL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 243 PDRPTIPGEQPAKKKylrwfprsppaltgrdaeihyhdlkrvyhrsawtlqDLLRVFLDWRLWPLLIMYFGVVGVGIGVQ 322
Cdd:COG0738  187 PEIEEEEEEAAGSAA------------------------------------SLKSLLKNPRLLLGGLAIFLYVGAEGAIG 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 323 SYATVIIKAInPNLSGIDLSLLSAPIWLMDLAAILLVTPFSDRFHHHRAVFFSVpvllqILGLLLTTYAGTDTNSWPRYG 402
Cdd:COG0738  231 DWLPLYLKDV-LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSA-----LLAAVGLLLALLAPGPWLALI 304

                        330       340
                 ....*....|....*....|....*....
gi 169764565 403 GLLIVGFGLGPTVPITMTWTTEIFQPRHG 431
Cdd:COG0738  305 GLALVGLGLSLMFPTIFSLALDGLGKRTA 333
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 97-268 5.79e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 42.21  E-value: 5.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  97 QVSTALALFYVCYVVFDLPSNLIMSRLSPhvwmsRIVISVGIIGTCMTAMKAAWSFYLLRLLLGI-VIAGMWPGMAYYLT 175
Cdd:cd17353   39 SVALAFTLTIVFLAISAPFAGRLVDRGGP-----RKAILIGGILFGLGFILSAFAISLPLLFLGYgVLGGIGAGIGYITP 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 176 L------FypPSRTGKRIGqyytaaqLSAAAVGLVSAGF-QKMDGVRGYVGFQWMFLVWGVITIAVGILLLWWLPDRPti 248
Cdd:cd17353  114 VstavkwF--PDKRGLATG-------IVIAGFGLGSLIFsPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPP-- 182

                        170       180
                 ....*....|....*....|
gi 169764565 249 PGEQPAKKKYLRWFPRSPPA 268
Cdd:cd17353  183 KGWVPPGVDPLANNAENSPR 202
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 89-260 7.37e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 41.84  E-value: 7.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  89 DVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPhvwmsRIVISVGIIGTCMTAMKAAWSFYLLRLLLGIVIAGMW- 167
Cdd:cd17475   24 EDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGE-----RRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGy 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 168 ----PGMAYYLTLFYPPSRTGKRIGQYYTAAQLSAAavgLVSAGFQKMDGVRgyvGFQWMFLVWGVITIAVGILLLWWLP 243
Cdd:cd17475   99 gsvqPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGA---LAAALLPPLALHY---GWRAAFVVAGLVSILAAVLFWLFYR 172

                        170
                 ....*....|....*..
gi 169764565 244 DRPTIPGEQPAKKKYLR 260
Cdd:cd17475  173 EPPAASAATESASTLLR 189
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
89-243 8.16e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 41.76  E-value: 8.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  89 DVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPHVWMsRIVISVGIIGTCMTAM--KAAWSFYLLrLLLGIVIAGM 166
Cdd:COG0738  239 DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLL-RLSALLAAVGLLLALLapGPWLALIGL-ALVGLGLSLM 316

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 169764565 167 WPgmayylTLFyppSRTGKRIGQYytaaqlSAAAVGLVSAGfqkmdgvrGYVGFQWMFLVWGVITIAVGILLLWWLP 243
Cdd:COG0738  317 FP------TIF---SLALDGLGKR------TAAAVSAVLIM--------GIVGGAIGPPLIGFLADAFGLRAAFLVP 370
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 127-271 1.28e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.00  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 127 VWMSRIVISVGIIGT-------------CMTAMKAAWSFYLLRLLLGIVIAGMWPGMAYYLTLFYPPSRTGKRIGQYYTA 193
Cdd:cd17477   49 PLVPRLIRRVGHIRAfaagaaitavsvlLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTV 128

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 169764565 194 AQLSAAAVGLVSAGFqkmdGVRGyvgfqWMFLVWGVITIAVGILLLWWLPdRPTIPGEQPAKKKYLRWFPRSPPALTG 271
Cdd:cd17477  129 LGLGFALGPLLLALV----GTAG-----ALPFLIAAVLLLLALVPLLLTR-RAAPEIEEAESISLRRLLRIAPLALLG 196
MFS_1 pfam07690
Major Facilitator Superfamily;
26-202 1.90e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.48  E-value: 1.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565   26 FRDGRDDVESGSEPDIADIERIYRKlDFRIIPAFWVLYFLCAAVRSNVSLAQTMNidtnhTIFDVLHVNDHQVSTALALF 105
Cdd:pfam07690 171 PRPPPESKRPKPAEEARLSLIVAWK-ALLRDPVLWLLLALLLFGFAFFGLLTYLP-----LYQEVLGLSALLAGLLLGLG 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  106 YVCYVVFDLPSNLIMSRLSPHVWMSRIVISVGIIGTCMTAM---KAAWSFYLLRLLLGIVIAGMWPGMAYYLTLFYPPSR 182
Cdd:pfam07690 245 GLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLsltLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEE 324

                         170       180
                  ....*....|....*....|
gi 169764565  183 TGKRIGQYYTAAQLsAAAVG 202
Cdd:pfam07690 325 RGTASGLYNTAGSL-GGALG 343
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
89-200 2.99e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.96  E-value: 2.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  89 DVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPHVWMSRIVISVGIIGTCMTAMKAAWSFYLLRLLLGIVIAGMWP 168
Cdd:COG2814  236 EVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFP 315

                         90       100       110
                 ....*....|....*....|....*....|..
gi 169764565 169 GMAYYLTLFYPPSRTGKRIGQYYTAAQLSAAA 200
Cdd:COG2814  316 LLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 132-238 3.27e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 39.89  E-value: 3.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 132 IVISVGIIGTCMTAMKAAWSFYLL---RLLLGIVIAGMWPGMAYYLTLFYPPSRTGKRIGQYYTAAQLSAAAVGLVSAGF 208
Cdd:cd17316   69 LILTLLLFGLATLLIGLLPTPILLlvlRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLL 148

                         90       100       110
                 ....*....|....*....|....*....|
gi 169764565 209 qkMDGVRGYVGFQWMFLVwGVITIAVGILL 238
Cdd:cd17316  149 --IPLLSGDWGWRILFLI-GALPALLALLL 175
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 87-240 3.36e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.91  E-value: 3.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  87 IFDVLHVNDHQVSTALALFYVCYVVfdlpSNLIMSRLSPHVWMSRIV-ISVGIIGTCMTAMkaAWSFYLLRLLLGIVIAG 165
Cdd:cd06173  235 AKEVLGGGAAGYGLLLAAFGVGALL----GALLLGRLSKRRRRGRLLlIGALLLGLALLVL--GLSPSLWLLLAALFLLG 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 166 MWPG--MAYYLTLFY---PPSRTGKRIGQYYT----AAQLSAAAVGLVSAGFqkmdgvrgyvGFQWMFLVWGVITIAVGI 236
Cdd:cd06173  309 LAGGlfNVPLNTLLQlrvPDELRGRVFSVYNAlnsgAMPLGALLAGLLADAL----------GLSAVFLLAGALLLLAAL 378


                 ....
gi 169764565 237 LLLW 240
Cdd:cd06173  379 LLLL 382
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 99-266 4.04e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 39.45  E-value: 4.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  99 STALALFYVCYVVFDLPSNLIMSRLSPHVWMSRIVISVGIIGTCMTAMKAAW--SFYLLrLLLGIVIAGMwpGMAYYLTL 176
Cdd:cd17471   31 PLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLFAFlrNYWVL-LLVGVVLLSL--GAAAFPQL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 177 F-----YPPSRTGKRIGQYYTA--AQLSAAAVGLVSAGFqkmdGVRGYVGFQWMFLVWGVITIAVGILLLWWLPDRPTIP 249
Cdd:cd17471  108 FalareYADRSSGRDATLFNSVlrAAFSLAWVIGPPLAF----LLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPA 183

                        170
                 ....*....|....*..
gi 169764565 250 GEQPAKKKYLRWFPRSP 266
Cdd:cd17471  184 QKATPASSLVKAPVNRR 200
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
89-243 5.33e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.50  E-value: 5.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  89 DVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPH-VWM-SRIVISVGIIGTCMTAMKAAWSFYLLRLLLGIVIAGM 166
Cdd:COG2211  257 YVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKkAFIiGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAI 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 167 WPGMAYYLTLFYPPS--RTGKRI-GQYY---TAAQLSAAAVGLVSAGFqkMDGVRGYV-----------GFQWMFLVWGV 229
Cdd:COG2211  337 LVLPWAMLADVVDYDewKTGRRReGLYFgifTFAIKLGQALAGALAGL--LLALFGYVagaaqspsaltGIRLLFFLLPA 414

                        170
                 ....*....|....
gi 169764565 230 ITIAVGILLLWWLP 243
Cdd:COG2211  415 VLLLLAALLLLFYP 428
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 89-255 7.49e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 38.75  E-value: 7.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  89 DVLHVNDHQVSTALALFYVCYVVFDLPSNLIMSRLSPhvwmsRIVISVGIIGTC-----MTAMKAAWSFYLLRLLLGIVI 163
Cdd:cd17329   28 QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGR-----KPVMLAGLLLRAlgfalLGFAHSPWLFAIALVLTGFGG 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 164 AGMWPGMAYYLTLFYPPSRTGKRIGQYYTAAQLSAAAVGLVSAGFqkmdgvrGYVGFQWMFLVWGVITIAVGILLLWWLP 243
Cdd:cd17329  103 GLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL-------LLYSFRLLFLAAAVLFLLAALVLLFLLP 175

                        170
                 ....*....|..
gi 169764565 244 DRPTIPGEQPAK 255
Cdd:cd17329  176 ETRPKRRAAEKT 187
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
89-425 9.94e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 38.34  E-value: 9.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565  89 DVLHVNDHQVSTALALfyvcYVVFDLPSNLIMSRLSPHVWmSR-------IVISVGIIGTCMTAM---------KAAWSF 152
Cdd:COG2211   39 DVLGLSAALVGLILLV----ARLWDAITDPLIGALSDRTR-TRwgrrrpwILIGAIPLALSFVLLftapdlsptGKLIYA 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 153 YLLRLLLGIVIAGMWPGmayYLTLFY-----PPSRTgkRIGQY-YTAAQLSAAAVGLVSAGFQKMDGVRGYVGFQWMFLV 226
Cdd:COG2211  114 LVTYLLLGLAYTLVNIP---YSALGAeltpdYEERT--RLSSWrFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 227 WGVITIAVGILLLWWLPDRPTIPGEQPAkkkylrwfprsppaltgrdaeihyhdlkrvyhrsawTLQDLLRVFLDWRLWP 306
Cdd:COG2211  189 FAVLGLLAFLLTFFGTKERPVPEEEKVS------------------------------------LKESLKALLKNRPFLL 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169764565 307 LLIMYFGVVGVGIGVQSYATVIIKAINpNLSGIDLSLLSAPIWLMDLAAILLVTPFSDRFHHHRAVFFSVPVLLQILGLL 386
Cdd:COG2211  233 LLLAYLLFFLALALVAALLLYYFKYVL-GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 169764565 387 LTTYAGtdtNSWPRYGGLLIVGFGLGPTVPITMTWTTEI 425
Cdd:COG2211  312 FFLGPG---NLWLLLVLAALAGIGLGAILVLPWAMLADV 347
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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