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Conserved domains on  [gi|169648710|gb|ACA62368|]
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NADH dehydrogenase subunit 3 (mitochondrion) [Drosophila signata]

Protein Classification

NADH dehydrogenase subunit 3( domain architecture ID 10009596)

NADH dehydrogenase subunit 3 is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that couples the transfer of electrons from NADH to quinone with the translocation of protons across the membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND3 MTH00161
NADH dehydrogenase subunit 3; Provisional
 12-115 2.44e-28

NADH dehydrogenase subunit 3; Provisional


:

Pssm-ID: 177217 [Multi-domain]  Cd Length: 113  Bit Score: 99.47  E-value: 2.44e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169648710  12 LMISIIVMILASILSKKTLVDREKSSPFECGFDPKSSSRLPF************IFDVE*ALILPMI*ILKFSNIMIWTI 91
Cdd:MTH00161  10 LLISIILMILASLLSKKSIMDREKSSPFECGFDPKSSARLPFSLRFFLIAIIFLIFDVEIALLLPMIFIFKTSNMMSWLI 89

                         90       100
                 ....*....|....*....|....
gi 169648710  92 TSIIFILILLLGLYHEWNQGMLNW 115
Cdd:MTH00161  90 TSSFFILILLLGLYYEWNQGALEW 113
 
Name Accession Description Interval E-value
ND3 MTH00161
NADH dehydrogenase subunit 3; Provisional
 12-115 2.44e-28

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177217 [Multi-domain]  Cd Length: 113  Bit Score: 99.47  E-value: 2.44e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169648710  12 LMISIIVMILASILSKKTLVDREKSSPFECGFDPKSSSRLPF************IFDVE*ALILPMI*ILKFSNIMIWTI 91
Cdd:MTH00161  10 LLISIILMILASLLSKKSIMDREKSSPFECGFDPKSSARLPFSLRFFLIAIIFLIFDVEIALLLPMIFIFKTSNMMSWLI 89

                         90       100
                 ....*....|....*....|....
gi 169648710  92 TSIIFILILLLGLYHEWNQGMLNW 115
Cdd:MTH00161  90 TSSFFILILLLGLYYEWNQGALEW 113
Oxidored_q4 pfam00507
NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;
19-76 5.95e-07

NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;


Pssm-ID: 459838 [Multi-domain]  Cd Length: 94  Bit Score: 43.95  E-value: 5.95e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 169648710   19 MILASILSKKTlVDREKSSPFECGFDPKSSSRLPF************IFDVE*ALILP 76
Cdd:pfam00507   1 LLLSRLLGPKR-PNPEKLSPYECGFDPVGDARLRFSVRFYLVAILFLIFDVEVVFLFP 57
NuoA COG0838
NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH: ...
 12-76 1.83e-05

NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 3 (chain A) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440600 [Multi-domain]  Cd Length: 117  Bit Score: 40.49  E-value: 1.83e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 169648710  12 LMISIIVMILASILSKKTlVDREKSSPFECGFDPKSSSRLPF************IFDVE*ALILP 76
Cdd:COG0838   16 LGLALAMLLLSRLLGPKR-PNPEKLSPYECGIEPVGDARIRFSVRYYLVALLFVIFDVEVVFLFP 79
 
Name Accession Description Interval E-value
ND3 MTH00161
NADH dehydrogenase subunit 3; Provisional
 12-115 2.44e-28

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177217 [Multi-domain]  Cd Length: 113  Bit Score: 99.47  E-value: 2.44e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169648710  12 LMISIIVMILASILSKKTLVDREKSSPFECGFDPKSSSRLPF************IFDVE*ALILPMI*ILKFSNIMIWTI 91
Cdd:MTH00161  10 LLISIILMILASLLSKKSIMDREKSSPFECGFDPKSSARLPFSLRFFLIAIIFLIFDVEIALLLPMIFIFKTSNMMSWLI 89

                         90       100
                 ....*....|....*....|....
gi 169648710  92 TSIIFILILLLGLYHEWNQGMLNW 115
Cdd:MTH00161  90 TSSFFILILLLGLYYEWNQGALEW 113
ND3 MTH00202
NADH dehydrogenase subunit 3; Provisional
 1-115 3.62e-21

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 214455 [Multi-domain]  Cd Length: 117  Bit Score: 81.19  E-value: 3.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169648710   1 MFSIIFIASIILMISIIVMILASILSKKTLVDREKSSPFECGFDPKSSSRLPF************IFDVE*ALILPMI*I 80
Cdd:MTH00202   1 MLLILFMSILSILISSLLFLVSWMLSFRSLMDREKSSPFECGFDPKESARLPFSMRFFLLAVIFLVFDIEIALLLPLPLV 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 169648710  81 LKFSNIMIWTITSIIFILILLLGLYHEWNQGMLNW 115
Cdd:MTH00202  81 LKSSWSKGGLLGGTIFLLILIGGLIHEWKEGSLDW 115
ND3 MTH00148
NADH dehydrogenase subunit 3; Provisional
 1-117 4.20e-21

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 214433 [Multi-domain]  Cd Length: 117  Bit Score: 81.06  E-value: 4.20e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169648710   1 MFSIIFIASIILMISIIVMILASILSKKTLVDREKSSPFECGFDPKSSSRLPF************IFDVE*ALILPMI*I 80
Cdd:MTH00148   1 MLSILLSLLFALILSPVLLLLGLVLSKRSYSDREKSSPFECGFDPISSARSPFSLRFFLLAILFLVFDVEIVLLFPVLQS 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 169648710  81 LKFSNIMIWTITSIIFILILLLGLYHEWNQGMLNWSS 117
Cdd:MTH00148  81 LGSSFSVWSLTSLFIFLLILILGLFHEWNEGSLDWVS 117
ND3 MTH00012
NADH dehydrogenase subunit 3; Validated
 1-117 4.92e-18

NADH dehydrogenase subunit 3; Validated


Pssm-ID: 164588 [Multi-domain]  Cd Length: 117  Bit Score: 73.35  E-value: 4.92e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169648710   1 MFSIIFIASIILMISIIVMILASILSKKTLVDREKSSPFECGFDPKSSSRLPF************IFDVE*ALILPMI*I 80
Cdd:MTH00012   1 MSLMMIPMMISLILPPLVLGAAWVLAARSTADREKTSPFECGFDPHKTARIPFSLRFFLLAIIFIVFDIEIVLLMPVPTI 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 169648710  81 LKFSNIMIWTITSIIFILILLLGLYHEWNQGMLNWSS 117
Cdd:MTH00012  81 LMTSTSKTVVYTSILFLLILVIGLIHEWREGSLDWSS 117
ND3 MTH00042
NADH dehydrogenase subunit 3; Validated
 1-115 4.33e-13

NADH dehydrogenase subunit 3; Validated


Pssm-ID: 177117 [Multi-domain]  Cd Length: 116  Bit Score: 60.38  E-value: 4.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169648710   1 MFSIIFIASIILMISIIVMILASILSKKTLvDREKSSPFECGFDPKSSSRLPF************IFDVE*ALILPMI*I 80
Cdd:MTH00042   1 MTNLIFFLLIILILTSLLLLAGHFLPSRSP-DLEKSSPYECGFDPLNSARLPFSFRFFLVAILFLLFDLEIALLFPLPPA 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 169648710  81 LKFSNIMIWTITSIIFILILLLGLYHEWNQGMLNW 115
Cdd:MTH00042  80 TLITNPSTLLPISLIFLIILTIGLVYEWVNGGLEW 114
ND3 MTH00203
NADH dehydrogenase subunit 3; Provisional
 12-115 7.08e-12

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 214456 [Multi-domain]  Cd Length: 112  Bit Score: 57.21  E-value: 7.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169648710  12 LMISIIVMILASILSK--KTLVDREKSSPFECGFDPKSSSRLPF************IFDVE*ALILPMI*ILKFSNIMIW 89
Cdd:MTH00203   9 LIALLLSLILLFIAFWlpKVNPDGEKLSPYECGFDPLGSARLPFSLQFFLVALSFLLFDLEIALLLPLPWSNQLSSLSLL 88

                         90       100
                 ....*....|....*....|....*.
gi 169648710  90 tiTSIIFILILLLGLYHEWNQGMLNW 115
Cdd:MTH00203  89 --LAFLFLILLTLGLIYEWLQGGLEW 112
ND3 MTH00113
NADH dehydrogenase subunit 3; Provisional
 12-115 3.90e-11

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177175 [Multi-domain]  Cd Length: 114  Bit Score: 55.27  E-value: 3.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169648710  12 LMISIIVMILASILSKkTLVDREKSSPFECGFDPKSSSRLPF************IFDVE*ALILPMI*ILKFSNIMIWTI 91
Cdd:MTH00113  11 LALSTILTTLNFWLTQ-TKPDNEKLSPYECGFDPLGSARLPFSIRFFLVAILFLLFDLEIALLLPLPWAINLTTPTTTLT 89

                         90       100
                 ....*....|....*....|....
gi 169648710  92 TSIIFILILLLGLYHEWNQGMLNW 115
Cdd:MTH00113  90 WATIILTLLTLGLIYEWLQGGLEW 113
ND3 MTH00106
NADH dehydrogenase subunit 3; Provisional
 34-116 4.90e-11

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177168 [Multi-domain]  Cd Length: 115  Bit Score: 55.33  E-value: 4.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169648710  34 EKSSPFECGFDPKSSSRLPF************IFDVE*ALILPMI*ILKFSNIMIWTITSIIFILILLLGLYHEWNQGML 113
Cdd:MTH00106  32 EKASPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWASQTNNLNTMLTMALLLISLLALSLAYEWTQKGL 111


                 ...
gi 169648710 114 NWS 116
Cdd:MTH00106 112 EWT 114
ND3 MTH00136
NADH dehydrogenase subunit 3; Provisional
 12-77 2.90e-09

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177194 [Multi-domain]  Cd Length: 116  Bit Score: 50.69  E-value: 2.90e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 169648710  12 LMISIIVMILASILSKKTlVDREKSSPFECGFDPKSSSRLPF************IFDVE*ALILPM 77
Cdd:MTH00136  12 IALSLILAIVSFWLPQMT-PDHEKLSPYECGFDPLGSARLPFSLRFFLVAILFLLFDLEIALLLPL 76
ND3 MTH00069
NADH dehydrogenase subunit 3; Provisional
 12-115 7.20e-09

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177141 [Multi-domain]  Cd Length: 114  Bit Score: 49.61  E-value: 7.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169648710  12 LMISIIVMILASILS---KKTLVDREKSSPFECGFDPKSSSRLPF************IFDVE*ALILPM---I*ILKFSN 85
Cdd:MTH00069   6 LLISTILSLILITISfwlPLNNPDSEKLSPYECGFDPLGSARLPFSIRFFLVAILFLLFDLEIALLLPTpwaSQLNTPTN 85

                         90       100       110
                 ....*....|....*....|....*....|
gi 169648710  86 IMIWTITSIIFILILLLglyHEWNQGMLNW 115
Cdd:MTH00069  86 TLFWSTLILILLTLGLI---YEWIQGGLEW 112
Oxidored_q4 pfam00507
NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;
19-76 5.95e-07

NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;


Pssm-ID: 459838 [Multi-domain]  Cd Length: 94  Bit Score: 43.95  E-value: 5.95e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 169648710   19 MILASILSKKTlVDREKSSPFECGFDPKSSSRLPF************IFDVE*ALILP 76
Cdd:pfam00507   1 LLLSRLLGPKR-PNPEKLSPYECGFDPVGDARLRFSVRFYLVAILFLIFDVEVVFLFP 57
PRK06602 PRK06602
NADH:ubiquinone oxidoreductase subunit A; Validated
 14-76 5.03e-06

NADH:ubiquinone oxidoreductase subunit A; Validated


Pssm-ID: 180638 [Multi-domain]  Cd Length: 121  Bit Score: 42.16  E-value: 5.03e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 169648710  14 ISIIVMILASILSKKTlVDREKSSPFECGFDPKSSSRLPF************IFDVE*ALILP 76
Cdd:PRK06602  21 LGILLLVAGKLLGPRA-PDREKNSPYESGFEAFGDARMKFDVRFYLVAILFVIFDLEAAFLFP 82
ND3 MTH00055
NADH dehydrogenase subunit 3; Provisional
 12-76 1.62e-05

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177128 [Multi-domain]  Cd Length: 118  Bit Score: 40.85  E-value: 1.62e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 169648710  12 LMISIIVMILASILSKKTLV---DREKSSPFECGFDPKSSSRLPF************IFDVE*ALILP 76
Cdd:MTH00055  12 LLFSIGLSTVISGASYIVGVkqpDSEKVSVYECGFDPFESSRIPFSVRFFLVGILFLIFDLEISFLFP 79
NuoA COG0838
NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH: ...
 12-76 1.83e-05

NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 3 (chain A) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440600 [Multi-domain]  Cd Length: 117  Bit Score: 40.49  E-value: 1.83e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 169648710  12 LMISIIVMILASILSKKTlVDREKSSPFECGFDPKSSSRLPF************IFDVE*ALILP 76
Cdd:COG0838   16 LGLALAMLLLSRLLGPKR-PNPEKLSPYECGIEPVGDARIRFSVRYYLVALLFVIFDVEVVFLFP 79
ND3 MTH00030
NADH dehydrogenase subunit 3; Provisional
 32-115 3.17e-05

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 164603 [Multi-domain]  Cd Length: 123  Bit Score: 40.30  E-value: 3.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169648710  32 DREKSSPFECGFDPKSSSRLPF************IFDVE*ALILPMI*ILKFSNIMIWTITSIIFILILLLGLYhEWNQG 111
Cdd:MTH00030  40 DSEKSSIYECGFDPFGKIRTPFTIKFVLVGILFMIFDIEISFLFPWSIVFNQLNLFSFWIVYTFLIVLAIGLAY-EWIKG 118


                 ....
gi 169648710 112 MLNW 115
Cdd:MTH00030 119 GLEW 122
ND3 MTH00018
NADH dehydrogenase subunit 3; Validated
 13-76 1.12e-03

NADH dehydrogenase subunit 3; Validated


Pssm-ID: 164592 [Multi-domain]  Cd Length: 113  Bit Score: 35.81  E-value: 1.12e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 169648710  13 MISIIVMILASILSKKTlVDREKSSPFECGFDPKSSSRLPF************IFDVE*ALILP 76
Cdd:MTH00018  12 VLSALFSGASYFLGVKQ-PDREKVSAYECGFDPFGFPGRPFSIRFFLIGILFLIFDLEISFLFP 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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