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Conserved domains on  [gi|1696198889|ref|XP_029568284|]
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interferon a3-like isoform X1 [Salmo trutta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IFab super family cl00092
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon ...
 67-202 2.45e-14

Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. Interferons produce antiviral and antiproliferative responses in cells. Receptor specificity determines function of the various members of the family.


The actual alignment was detected with superfamily member pfam00143:

Pssm-ID: 469611  Cd Length: 160  Bit Score: 67.60  E-value: 2.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696198889  67 HKFIQHSETLMNLLNIMGGEFTT----DSVDVPFPEDLYkQAELLPTDDTIWFILQTLDKIAELFDGELDS-VWDEKKVE 141
Cdd:pfam00143   3 QQLRLSNRENLKLLNQMRRSSPQsclkDRKDFKFPQEIL-SGSQLQKEQAALVLHEMLQQIFNLFSTNHSSaAWNETLLE 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1696198889 142 IFLSVLTSQSDGLQSCVTAQKKNSKN----------LQMYFKRLNNqVLKRMAYSAHAWELVRKEVRTHLM 202
Cdd:pfam00143  82 QLLNGLHQQLEDLETCLGEEMEEEESplgnedsrlaLKKYFQRIHL-YLKEKEYSSCAWEVVRVEIRRCFS 151
 
Name Accession Description Interval E-value
Interferon pfam00143
Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical ...
 67-202 2.45e-14

Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily,which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules.


Pssm-ID: 459689  Cd Length: 160  Bit Score: 67.60  E-value: 2.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696198889  67 HKFIQHSETLMNLLNIMGGEFTT----DSVDVPFPEDLYkQAELLPTDDTIWFILQTLDKIAELFDGELDS-VWDEKKVE 141
Cdd:pfam00143   3 QQLRLSNRENLKLLNQMRRSSPQsclkDRKDFKFPQEIL-SGSQLQKEQAALVLHEMLQQIFNLFSTNHSSaAWNETLLE 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1696198889 142 IFLSVLTSQSDGLQSCVTAQKKNSKN----------LQMYFKRLNNqVLKRMAYSAHAWELVRKEVRTHLM 202
Cdd:pfam00143  82 QLLNGLHQQLEDLETCLGEEMEEEESplgnedsrlaLKKYFQRIHL-YLKEKEYSSCAWEVVRVEIRRCFS 151
IFab cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon ...
 89-198 3.99e-08

Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. Interferons produce antiviral and antiproliferative responses in cells. Receptor specificity determines function of the various members of the family.


Pssm-ID: 238047  Cd Length: 152  Bit Score: 50.80  E-value: 3.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696198889  89 TDSVDVPFPEDLyKQAELLPTDDTIWFILQTLDKIAELFDGELDSV-WDEKKVEIFLSVLTSQSDGLQSCVTAQ--KKNS 165
Cdd:cd00095    29 KDRADFGFPQEL-LQGDQFQKAQAASVLHEMLQQIFNIFSTPSSSAaWNETLLESLLNELHQQLNHLETCLEQEmgEEET 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1696198889 166 KNLQM-------YFKRLNnQVLKRMAYSAHAWELVRKEVR 198
Cdd:cd00095   108 PGPRNthlhlrkYFQRIQ-LYLKEKKYSPCAWEVVRAEIM 146
IFabd smart00076
Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative ...
 93-198 7.34e-06

Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon.


Pssm-ID: 197503  Cd Length: 117  Bit Score: 43.45  E-value: 7.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696198889   93 DVPFPEDLyKQAELLPTDDTIWFILQTLDKIAELFDGELDSV-WDEKKVEIFLSVLTSQSDGLQSCVTAQ---------K 162
Cdd:smart00076   1 DFAFPEEI-LDGSQFQKAQAASVIHEMLQQIFNIFSSPSSSAaWNETLLESLLNELHQQLNHLEACLKQQmgeeetpltR 79

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1696198889  163 KNSKNLQMYFKRLNnQVLKRMAYSAHAWELVRKEVR 198
Cdd:smart00076  80 NTHLALKKYFQRIQ-LYLKEKKYSPCAWEVVRVEIR 114
 
Name Accession Description Interval E-value
Interferon pfam00143
Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical ...
 67-202 2.45e-14

Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily,which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules.


Pssm-ID: 459689  Cd Length: 160  Bit Score: 67.60  E-value: 2.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696198889  67 HKFIQHSETLMNLLNIMGGEFTT----DSVDVPFPEDLYkQAELLPTDDTIWFILQTLDKIAELFDGELDS-VWDEKKVE 141
Cdd:pfam00143   3 QQLRLSNRENLKLLNQMRRSSPQsclkDRKDFKFPQEIL-SGSQLQKEQAALVLHEMLQQIFNLFSTNHSSaAWNETLLE 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1696198889 142 IFLSVLTSQSDGLQSCVTAQKKNSKN----------LQMYFKRLNNqVLKRMAYSAHAWELVRKEVRTHLM 202
Cdd:pfam00143  82 QLLNGLHQQLEDLETCLGEEMEEEESplgnedsrlaLKKYFQRIHL-YLKEKEYSSCAWEVVRVEIRRCFS 151
IFab cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon ...
 89-198 3.99e-08

Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. Interferons produce antiviral and antiproliferative responses in cells. Receptor specificity determines function of the various members of the family.


Pssm-ID: 238047  Cd Length: 152  Bit Score: 50.80  E-value: 3.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696198889  89 TDSVDVPFPEDLyKQAELLPTDDTIWFILQTLDKIAELFDGELDSV-WDEKKVEIFLSVLTSQSDGLQSCVTAQ--KKNS 165
Cdd:cd00095    29 KDRADFGFPQEL-LQGDQFQKAQAASVLHEMLQQIFNIFSTPSSSAaWNETLLESLLNELHQQLNHLETCLEQEmgEEET 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1696198889 166 KNLQM-------YFKRLNnQVLKRMAYSAHAWELVRKEVR 198
Cdd:cd00095   108 PGPRNthlhlrkYFQRIQ-LYLKEKKYSPCAWEVVRAEIM 146
IFabd smart00076
Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative ...
 93-198 7.34e-06

Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon.


Pssm-ID: 197503  Cd Length: 117  Bit Score: 43.45  E-value: 7.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696198889   93 DVPFPEDLyKQAELLPTDDTIWFILQTLDKIAELFDGELDSV-WDEKKVEIFLSVLTSQSDGLQSCVTAQ---------K 162
Cdd:smart00076   1 DFAFPEEI-LDGSQFQKAQAASVIHEMLQQIFNIFSSPSSSAaWNETLLESLLNELHQQLNHLEACLKQQmgeeetpltR 79

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1696198889  163 KNSKNLQMYFKRLNnQVLKRMAYSAHAWELVRKEVR 198
Cdd:smart00076  80 NTHLALKKYFQRIQ-LYLKEKKYSPCAWEVVRVEIR 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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