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Conserved domains on  [gi|1696107625|ref|XP_029551994|]
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zinc finger protein 260-like [Salmo trutta]

Protein Classification

COG5048 and zf-C2H2 domain-containing protein( domain architecture ID 11472955)

COG5048 and zf-C2H2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
432-738 3.32e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 3.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 432 RPHLCSECGKSFRTKSVLEKHKRIHTGEKPFKC--ETCGAAFGHKGNLVRHQVLHTGERPYKCKVCGKSYPQSTD-LKAH 508
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASsSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 509 MHRHGATKPFMCDLCGKTFIYNYQMrQHNLQWHMAEGDKVPGREGTSTKPFSCK-----------ICLNGFSSMLTLKKH 577
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQ-LPDLLSISNLRNNPLPGNNSSSVNTPQSnslhpplpansLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 578 KEIHTGQKQYACSICGKTIAYKNAFDYHMRVH---------------------------SGVKPHECKYCGRKFILKQAL 630
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssslplttnsqlspksllsqspsslsSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 631 QGHERTHTGE-------KPFKCSYCDKTFAVNTNLKRHER--IHTGE--KPFKCDV--CGRGFSQANNVKAHMQVHTGVR 697
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1696107625 698 PYYCK--RCGKGFSDIRHYKNHSCdgmaaTRTHCDGDNYRKSS 738
Cdd:COG5048   351 PAKEKllNSSSKFSPLLNNEPPQS-----LQQYKDLKNDKKSE 388
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
130-412 1.15e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 130 PVDLPLLPGMTAASALPGNVSQANTVTNATSVCAGPAEvcSNPTETTSLEYDSSLGDTHGLNT--EPSPRDTESNVEHMR 207
Cdd:COG5048   162 PQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSS--SENSPLSSSYSIPSSSSDQNLENssSSLPLTTNSQLSPKS 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 208 AALPEGTDNgrdsherhkNSNTTNRTGSTENKRFKCDVCEKTFSKKELLRVHKLIHTKPFKCDMCEKTFSRKGLLEGHK- 286
Cdd:COG5048   240 LLSQSPSSL---------SSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLr 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 287 -LIHT----RPFTCDV--CDKTFSLNRMLLRHKLIHTGERPFAC--GQCGKTFR---MSKQLERHMLH---HKENYFSCK 351
Cdd:COG5048   311 sVNHSgeslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllNNEPPQSLQQYkdlKNDKKSETL 390

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1696107625 352 VCGNTFSTKTDLTQ--HRLVHAVERP--FKCLTCGKGFTKRTILMGHERIHTGEKPYSCAECGKS 412
Cdd:COG5048   391 SNSCIRNFKRDSNLslHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSF 455
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 404-426 7.00e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.00e-03
                          10        20
                  ....*....|....*....|...
gi 1696107625 404 YSCAECGKSYRQSYDLRIHMRRH 426
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
432-738 3.32e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 3.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 432 RPHLCSECGKSFRTKSVLEKHKRIHTGEKPFKC--ETCGAAFGHKGNLVRHQVLHTGERPYKCKVCGKSYPQSTD-LKAH 508
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASsSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 509 MHRHGATKPFMCDLCGKTFIYNYQMrQHNLQWHMAEGDKVPGREGTSTKPFSCK-----------ICLNGFSSMLTLKKH 577
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQ-LPDLLSISNLRNNPLPGNNSSSVNTPQSnslhpplpansLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 578 KEIHTGQKQYACSICGKTIAYKNAFDYHMRVH---------------------------SGVKPHECKYCGRKFILKQAL 630
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssslplttnsqlspksllsqspsslsSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 631 QGHERTHTGE-------KPFKCSYCDKTFAVNTNLKRHER--IHTGE--KPFKCDV--CGRGFSQANNVKAHMQVHTGVR 697
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1696107625 698 PYYCK--RCGKGFSDIRHYKNHSCdgmaaTRTHCDGDNYRKSS 738
Cdd:COG5048   351 PAKEKllNSSSKFSPLLNNEPPQS-----LQQYKDLKNDKKSE 388
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
130-412 1.15e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 130 PVDLPLLPGMTAASALPGNVSQANTVTNATSVCAGPAEvcSNPTETTSLEYDSSLGDTHGLNT--EPSPRDTESNVEHMR 207
Cdd:COG5048   162 PQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSS--SENSPLSSSYSIPSSSSDQNLENssSSLPLTTNSQLSPKS 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 208 AALPEGTDNgrdsherhkNSNTTNRTGSTENKRFKCDVCEKTFSKKELLRVHKLIHTKPFKCDMCEKTFSRKGLLEGHK- 286
Cdd:COG5048   240 LLSQSPSSL---------SSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLr 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 287 -LIHT----RPFTCDV--CDKTFSLNRMLLRHKLIHTGERPFAC--GQCGKTFR---MSKQLERHMLH---HKENYFSCK 351
Cdd:COG5048   311 sVNHSgeslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllNNEPPQSLQQYkdlKNDKKSETL 390

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1696107625 352 VCGNTFSTKTDLTQ--HRLVHAVERP--FKCLTCGKGFTKRTILMGHERIHTGEKPYSCAECGKS 412
Cdd:COG5048   391 SNSCIRNFKRDSNLslHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSF 455
zf-H2C2_2 pfam13465
Zinc-finger double domain;
657-682 2.54e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.54e-05
                          10        20
                  ....*....|....*....|....*.
gi 1696107625 657 NLKRHERIHTGEKPFKCDVCGRGFSQ 682
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 641-693 1.09e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.39  E-value: 1.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1696107625 641 KPFkCSYCDKTFAVNTNLKRHERIHTgekpFKCDVCGRGFSQANNVKAH-MQVH 693
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
391-415 4.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.22e-03
                          10        20
                  ....*....|....*....|....*
gi 1696107625 391 LMGHERIHTGEKPYSCAECGKSYRQ 415
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 404-426 7.00e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.00e-03
                          10        20
                  ....*....|....*....|...
gi 1696107625 404 YSCAECGKSYRQSYDLRIHMRRH 426
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
432-738 3.32e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 3.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 432 RPHLCSECGKSFRTKSVLEKHKRIHTGEKPFKC--ETCGAAFGHKGNLVRHQVLHTGERPYKCKVCGKSYPQSTD-LKAH 508
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASsSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 509 MHRHGATKPFMCDLCGKTFIYNYQMrQHNLQWHMAEGDKVPGREGTSTKPFSCK-----------ICLNGFSSMLTLKKH 577
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQ-LPDLLSISNLRNNPLPGNNSSSVNTPQSnslhpplpansLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 578 KEIHTGQKQYACSICGKTIAYKNAFDYHMRVH---------------------------SGVKPHECKYCGRKFILKQAL 630
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssslplttnsqlspksllsqspsslsSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 631 QGHERTHTGE-------KPFKCSYCDKTFAVNTNLKRHER--IHTGE--KPFKCDV--CGRGFSQANNVKAHMQVHTGVR 697
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1696107625 698 PYYCK--RCGKGFSDIRHYKNHSCdgmaaTRTHCDGDNYRKSS 738
Cdd:COG5048   351 PAKEKllNSSSKFSPLLNNEPPQS-----LQQYKDLKNDKKSE 388
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
289-718 8.98e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 8.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 289 HTRPFTCDVCDKTFSLNRMLLRHKLIHTGERPFACGQ--CGKTFRMSKQLERH-MLHHKENYFSCKVCGNTFSTKTDLTQ 365
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHlRTHHNNPSDLNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 366 HRLVH-AVERPFKCLTCGKGFTKRTILMGHERIHTGEKPYSCAECGKSYRQSY-DLRIHMrrhtgaDIRPHLCSECGKSF 443
Cdd:COG5048   110 LSSSSsNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHP------PLPANSLSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 444 RTKSVlekHKRIHTGEKPFKCETCGAAFGHKGNLVRHQVLHTGERPYKCKVCGKSYPQSTDLKAHMHRHGATKPFMCDLC 523
Cdd:COG5048   184 LSLLI---SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 524 GKTFIYNYQMRQHNLQwhmaegDKVPGREGTSTKPFSCKICLNGFSSMLTLKKHK--EIHTGQ--KQYAC--SICGKTIA 597
Cdd:COG5048   261 PRSSLPTASSQSSSPN------ESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFS 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 598 YKNAFDYHMRVHSGVKPHECKYCGRKFILKQALQG-------HERTHTGEKPFKCSY--CDKTFAVNTNLKRHERIHTGE 668
Cdd:COG5048   335 RNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSF 414

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1696107625 669 KP--FKCDVCGRGFSQANNVKAHMQVHTGVRPYYCKRCGKgFSDIRHYKNHS 718
Cdd:COG5048   415 RPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
130-412 1.15e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 130 PVDLPLLPGMTAASALPGNVSQANTVTNATSVCAGPAEvcSNPTETTSLEYDSSLGDTHGLNT--EPSPRDTESNVEHMR 207
Cdd:COG5048   162 PQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSS--SENSPLSSSYSIPSSSSDQNLENssSSLPLTTNSQLSPKS 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 208 AALPEGTDNgrdsherhkNSNTTNRTGSTENKRFKCDVCEKTFSKKELLRVHKLIHTKPFKCDMCEKTFSRKGLLEGHK- 286
Cdd:COG5048   240 LLSQSPSSL---------SSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLr 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 287 -LIHT----RPFTCDV--CDKTFSLNRMLLRHKLIHTGERPFAC--GQCGKTFR---MSKQLERHMLH---HKENYFSCK 351
Cdd:COG5048   311 sVNHSgeslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllNNEPPQSLQQYkdlKNDKKSETL 390

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1696107625 352 VCGNTFSTKTDLTQ--HRLVHAVERP--FKCLTCGKGFTKRTILMGHERIHTGEKPYSCAECGKS 412
Cdd:COG5048   391 SNSCIRNFKRDSNLslHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSF 455
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
402-579 3.94e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 3.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 402 KPYSCAECGKSYRQSYDLRIHMR--RHTGADIRPHLCSE--CGKSFRTKSVLEKHKRIHTGEKPFKC--ETCGAAFGHKG 475
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 476 NLVRHQ--VLHTGERPYKCKVC---GKSYPQSTDLKAHMHRH----GATKPFMCDLCGKTFIYNYQMRQHNlqwhmaegd 546
Cdd:COG5048   368 NNEPPQslQQYKDLKNDKKSETlsnSCIRNFKRDSNLSLHIIthlsFRPYNCKNPPCSKSFNRHYNLIPHK--------- 438

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1696107625 547 kvpgrEGTSTKPFSCKICLNGFSSMLTLKKHKE 579
Cdd:COG5048   439 -----KIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
657-682 2.54e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.54e-05
                          10        20
                  ....*....|....*....|....*.
gi 1696107625 657 NLKRHERIHTGEKPFKCDVCGRGFSQ 682
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 641-693 1.09e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.39  E-value: 1.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1696107625 641 KPFkCSYCDKTFAVNTNLKRHERIHTgekpFKCDVCGRGFSQANNVKAH-MQVH 693
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
629-653 2.65e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.65e-04
                          10        20
                  ....*....|....*....|....*
gi 1696107625 629 ALQGHERTHTGEKPFKCSYCDKTFA 653
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 459-541 6.50e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 6.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696107625 459 EKPFKCETCGAAFGHKGNLV-----RHQVLhTGERPYKCKV--CGKSYPQSTDLKAHM-HRHGA---------------- 514
Cdd:COG5189   315 KLPCTNSSSNGKLAHGGERNidtpsRMLKV-KDGKPYKCPVegCNKKYKNQNGLKYHMlHGHQNqklhenpspekmnifs 393

                          90       100
                  ....*....|....*....|....*....
gi 1696107625 515 --TKPFMCDLCGKTFIYNYQMRQHNLQWH 541
Cdd:COG5189   394 akDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
449-471 8.03e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.03e-04
                          10        20
                  ....*....|....*....|...
gi 1696107625 449 LEKHKRIHTGEKPFKCETCGAAF 471
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
391-415 4.22e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.22e-03
                          10        20
                  ....*....|....*....|....*
gi 1696107625 391 LMGHERIHTGEKPYSCAECGKSYRQ 415
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
476-499 4.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.99e-03
                          10        20
                  ....*....|....*....|....
gi 1696107625 476 NLVRHQVLHTGERPYKCKVCGKSY 499
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 404-426 7.00e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.00e-03
                          10        20
                  ....*....|....*....|...
gi 1696107625 404 YSCAECGKSYRQSYDLRIHMRRH 426
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
307-330 7.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.54e-03
                          10        20
                  ....*....|....*....|....
gi 1696107625 307 MLLRHKLIHTGERPFACGQCGKTF 330
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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