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Conserved domains on  [gi|1696103683|ref|XP_029595156|]
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zinc finger protein 501-like [Salmo trutta]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
175-502 1.67e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 1.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683 175 SHSDSGKSTSGQPDPKMAKpaRPHHCSHCGKSFTQLAALKTHERTHTGEKHFHCNL--CGKSFTRIGSLKTHERIHTGEK 252
Cdd:COG5048    13 NSVLSSTPKSTLKSLSNAP--RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNP 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683 253 PF-HCSLCGMSFTQLGNLKRHARIHTGEKPFHCSLCGKSFTQLATLKTHERTHTgekHFHCNLC----GKSFTRIGSLKT 327
Cdd:COG5048    91 SDlNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS---NLRNNPLpgnnSSSVNTPQSNSL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683 328 HERIHTGEKPFHCSLCGKSFTQLG-------ALKTHERTHTGEKNFHCSLCrKSFTQLGSMKTHERTHTREKHF------ 394
Cdd:COG5048   168 HPPLPANSLSKDPSSNLSLLISSNvstsipsSSENSPLSSSYSIPSSSSDQ-NLENSSSSLPLTTNSQLSPKSLlsqsps 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683 395 ---------HCSLCGKTFTQLGSMKTHERTHNGE-------KPYHCSQCQNTFSALRDLKSHERT--HLGERQRPFQC-- 454
Cdd:COG5048   247 slsssdsssSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpy 326

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1696103683 455 SQCGKRFIQSSHLKDHTTTHTGEKPFQC--SQCGKGFTRLSTLKTHKNTH 502
Cdd:COG5048   327 SLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
PTZ00121 super family cl31754
MAEBL; Provisional
 11-148 7.95e-03

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 7.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683   11 KEEAICWTEKESLKLNIVVKEKENISVKGEEE---AFRIKQEEEESisiTLKEEDVTVKEEKEHFGVEEeaiiLKEEDDT 87
Cdd:PTZ00121  1614 KAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEkkkAEELKKAEEEN---KIKAAEEAKKAEEDKKKAEE----AKKAEED 1686

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1696103683   88 VKEEKEPIGVKEEEMIEAVTVEEEEVEALI----MKKEEEDITLKEEEdiIMKEEEEPFRVKEEA 148
Cdd:PTZ00121  1687 EKKAAEALKKEAEEAKKAEELKKKEAEEKKkaeeLKKAEEENKIKAEE--AKKEAEEDKKKAEEA 1749
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
175-502 1.67e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 1.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683 175 SHSDSGKSTSGQPDPKMAKpaRPHHCSHCGKSFTQLAALKTHERTHTGEKHFHCNL--CGKSFTRIGSLKTHERIHTGEK 252
Cdd:COG5048    13 NSVLSSTPKSTLKSLSNAP--RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNP 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683 253 PF-HCSLCGMSFTQLGNLKRHARIHTGEKPFHCSLCGKSFTQLATLKTHERTHTgekHFHCNLC----GKSFTRIGSLKT 327
Cdd:COG5048    91 SDlNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS---NLRNNPLpgnnSSSVNTPQSNSL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683 328 HERIHTGEKPFHCSLCGKSFTQLG-------ALKTHERTHTGEKNFHCSLCrKSFTQLGSMKTHERTHTREKHF------ 394
Cdd:COG5048   168 HPPLPANSLSKDPSSNLSLLISSNvstsipsSSENSPLSSSYSIPSSSSDQ-NLENSSSSLPLTTNSQLSPKSLlsqsps 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683 395 ---------HCSLCGKTFTQLGSMKTHERTHNGE-------KPYHCSQCQNTFSALRDLKSHERT--HLGERQRPFQC-- 454
Cdd:COG5048   247 slsssdsssSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpy 326

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1696103683 455 SQCGKRFIQSSHLKDHTTTHTGEKPFQC--SQCGKGFTRLSTLKTHKNTH 502
Cdd:COG5048   327 SLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 280-328 2.88e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.54  E-value: 2.88e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1696103683 280 KPFhCSLCGKSFTQLATLKTHERthtgEKHFHCNLCGKSFTRIGSLKTH 328
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
268-293 6.70e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 6.70e-05
                          10        20
                  ....*....|....*....|....*.
gi 1696103683 268 NLKRHARIHTGEKPFHCSLCGKSFTQ 293
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PTZ00121 PTZ00121
MAEBL; Provisional
 11-148 7.95e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 7.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683   11 KEEAICWTEKESLKLNIVVKEKENISVKGEEE---AFRIKQEEEESisiTLKEEDVTVKEEKEHFGVEEeaiiLKEEDDT 87
Cdd:PTZ00121  1614 KAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEkkkAEELKKAEEEN---KIKAAEEAKKAEEDKKKAEE----AKKAEED 1686

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1696103683   88 VKEEKEPIGVKEEEMIEAVTVEEEEVEALI----MKKEEEDITLKEEEdiIMKEEEEPFRVKEEA 148
Cdd:PTZ00121  1687 EKKAAEALKKEAEEAKKAEELKKKEAEEKKkaeeLKKAEEENKIKAEE--AKKEAEEDKKKAEEA 1749
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
175-502 1.67e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 1.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683 175 SHSDSGKSTSGQPDPKMAKpaRPHHCSHCGKSFTQLAALKTHERTHTGEKHFHCNL--CGKSFTRIGSLKTHERIHTGEK 252
Cdd:COG5048    13 NSVLSSTPKSTLKSLSNAP--RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNP 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683 253 PF-HCSLCGMSFTQLGNLKRHARIHTGEKPFHCSLCGKSFTQLATLKTHERTHTgekHFHCNLC----GKSFTRIGSLKT 327
Cdd:COG5048    91 SDlNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS---NLRNNPLpgnnSSSVNTPQSNSL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683 328 HERIHTGEKPFHCSLCGKSFTQLG-------ALKTHERTHTGEKNFHCSLCrKSFTQLGSMKTHERTHTREKHF------ 394
Cdd:COG5048   168 HPPLPANSLSKDPSSNLSLLISSNvstsipsSSENSPLSSSYSIPSSSSDQ-NLENSSSSLPLTTNSQLSPKSLlsqsps 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683 395 ---------HCSLCGKTFTQLGSMKTHERTHNGE-------KPYHCSQCQNTFSALRDLKSHERT--HLGERQRPFQC-- 454
Cdd:COG5048   247 slsssdsssSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpy 326

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1696103683 455 SQCGKRFIQSSHLKDHTTTHTGEKPFQC--SQCGKGFTRLSTLKTHKNTH 502
Cdd:COG5048   327 SLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-347 1.74e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 1.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683 197 PHHCSHCGKSFTQLAALKTHERT--HTGE--KHFHC--NLCGKSFTRIGSLKTHERIHTGEKPFHCSL--CGMSFTQLGN 268
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLN 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683 269 LKRHARIH-----TGEKPFHCSL--CGKSFTQLATLKTHERTHT--GEKHFHCNLCGKSFTRIGSLKTHERIHTGEKPFH 339
Cdd:COG5048   369 NEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448


                  ....*...
gi 1696103683 340 CSLCGKSF 347
Cdd:COG5048   449 CSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
165-498 6.97e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 6.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683 165 DRISTRARPDSHSDSGKSTSGQPDPKMAKPARPHHCShcGKSFTQLAALKTHERTHTGEKHFHCNLCGKSFTRIGSLKTH 244
Cdd:COG5048   140 LLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSL--SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSD 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683 245 ERIHTGEKPFHCSLCGMSFTQLGNLKRHARIHTGEKPFHCSLCGKSFTQLATLKTH------ERTHTGEKHFH-CNLCGK 317
Cdd:COG5048   218 QNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSspnesdSSSEKGFSLPIkSKQCNI 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683 318 SFTRIGSLKTHER--IHTGE--KPFHC--SLCGKSFTQLGALKTHERTHTGEKNFHCSL--CRKSFTQLGSMKTHERTHT 389
Cdd:COG5048   298 SFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNNEPPQSLQQ 377

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683 390 RekhfhcslcgktftqlgsmKTHERTHNGEKPYHCsqCQNTFSALRDLKSHERTHLGERQRPFQCSQCGKRFIQSSHLKD 469
Cdd:COG5048   378 Y-------------------KDLKNDKKSETLSNS--CIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIP 436

                         330       340
                  ....*....|....*....|....*....
gi 1696103683 470 HTTTHTGEKPFQCSQCGKgFTRLSTLKTH 498
Cdd:COG5048   437 HKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 280-328 2.88e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.54  E-value: 2.88e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1696103683 280 KPFhCSLCGKSFTQLATLKTHERthtgEKHFHCNLCGKSFTRIGSLKTH 328
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVH 44
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 278-361 4.08e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 4.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683 278 GEKPFHCSL--CGKSFTQLATLKTHErthtgeKHFHCNlcgKSFTRIGSLKTHERIHTGEKPFHCSLCGKSFTQLGALKT 355
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHM------LHGHQN---QKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1696103683 356 HeRTHT 361
Cdd:COG5189   417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
268-293 6.70e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 6.70e-05
                          10        20
                  ....*....|....*....|....*.
gi 1696103683 268 NLKRHARIHTGEKPFHCSLCGKSFTQ 293
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
429-502 1.00e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.00e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1696103683 429 NTFSALRDLKSHERTHLGERQRPFQCSQCGKRFIQSSHLKDHTTTHTGEKPFQCSQ--CGKGFTRLSTLKTHKNTH 502
Cdd:COG5048    11 SNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTH 86
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 200-244 1.31e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 40.62  E-value: 1.31e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1696103683 200 CSHCGKSFTQLAALKTHERthtgEKHFHCNLCGKSFTRIGSLKTH 244
Cdd:cd20908     4 CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
324-349 2.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.52e-04
                          10        20
                  ....*....|....*....|....*.
gi 1696103683 324 SLKTHERIHTGEKPFHCSLCGKSFTQ 349
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
240-265 6.78e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.78e-04
                          10        20
                  ....*....|....*....|....*.
gi 1696103683 240 SLKTHERIHTGEKPFHCSLCGMSFTQ 265
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
212-237 8.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.58e-04
                          10        20
                  ....*....|....*....|....*.
gi 1696103683 212 ALKTHERTHTGEKHFHCNLCGKSFTR 237
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
297-321 1.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.20e-03
                          10        20
                  ....*....|....*....|....*
gi 1696103683 297 LKTHERTHTGEKHFHCNLCGKSFTR 321
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-377 1.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.79e-03
                          10        20
                  ....*....|....*....|....*.
gi 1696103683 352 ALKTHERTHTGEKNFHCSLCRKSFTQ 377
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
466-491 2.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 1696103683 466 HLKDHTTTHTGEKPFQCSQCGKGFTR 491
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PTZ00121 PTZ00121
MAEBL; Provisional
 11-148 7.95e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 7.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1696103683   11 KEEAICWTEKESLKLNIVVKEKENISVKGEEE---AFRIKQEEEESisiTLKEEDVTVKEEKEHFGVEEeaiiLKEEDDT 87
Cdd:PTZ00121  1614 KAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEkkkAEELKKAEEEN---KIKAAEEAKKAEEDKKKAEE----AKKAEED 1686

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1696103683   88 VKEEKEPIGVKEEEMIEAVTVEEEEVEALI----MKKEEEDITLKEEEdiIMKEEEEPFRVKEEA 148
Cdd:PTZ00121  1687 EKKAAEALKKEAEEAKKAEELKKKEAEEKKkaeeLKKAEEENKIKAEE--AKKEAEEDKKKAEEA 1749
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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