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Conserved domains on  [gi|1695800599|ref|WP_141099809|]
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type II toxin-antitoxin system RelB/DinJ family antitoxin, partial [Fibrobacter sp. UWH3]

Protein Classification

type II toxin-antitoxin system RelB/DinJ family antitoxin( domain architecture ID 10006901)

type II toxin-antitoxin (TA) system RelB/DinJ family antitoxin similar to Escherichia coli RelB and DinJ, the antitoxin components of the RelE-RelB and YafQ-DinJ TA modules, respectively; inhibit the effect of their cognate toxins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RelB COG3077
Antitoxin component of the RelBE or YafQ-DinJ toxin-antitoxin module [Defense mechanisms];
1-53 1.31e-17

Antitoxin component of the RelBE or YafQ-DinJ toxin-antitoxin module [Defense mechanisms];


:

Pssm-ID: 442311  Cd Length: 82  Bit Score: 68.36  E-value: 1.31e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1695800599  1 MATTVLQIRMDEDLKNEAADLFDKMGMDLPTAIRVFLKRAVAEKAIPFEVREP 53
Cdd:COG3077    2 MATANVNVRIDEELKEEAEAVLEELGLTPSDAIRMFLKQVVREGGLPFELKLP 54
 
Name Accession Description Interval E-value
RelB COG3077
Antitoxin component of the RelBE or YafQ-DinJ toxin-antitoxin module [Defense mechanisms];
1-53 1.31e-17

Antitoxin component of the RelBE or YafQ-DinJ toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442311  Cd Length: 82  Bit Score: 68.36  E-value: 1.31e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1695800599  1 MATTVLQIRMDEDLKNEAADLFDKMGMDLPTAIRVFLKRAVAEKAIPFEVREP 53
Cdd:COG3077    2 MATANVNVRIDEELKEEAEAVLEELGLTPSDAIRMFLKQVVREGGLPFELKLP 54
RelB_DinJ TIGR02384
addiction module antitoxin, RelB/DinJ family; Plasmids may be maintained stably in bacterial ...
 1-53 3.04e-16

addiction module antitoxin, RelB/DinJ family; Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all were found adjacent to toxin genes. The resulting model appears to describe a narrower set of proteins than pfam04221, although many in the scope of this model are not obviously paired with toxin proteins. Several toxin/antitoxin pairs may occur in a single species. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other]


Pssm-ID: 274102  Cd Length: 84  Bit Score: 65.03  E-value: 3.04e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1695800599  1 MATTVLQIRMDEDLKNEAADLFDKMGMDLPTAIRVFLKRAVAEKAIPFEVREP 53
Cdd:TIGR02384  1 MATATISIRIDEELKKEAYAVFEELGLTPSTAIRMFLKQVIREQGLPFDLRLP 53
RelB pfam04221
RelB antitoxin; RelE and RelB form a toxin-antitoxin system. RelE represses translation, ...
 6-53 2.47e-09

RelB antitoxin; RelE and RelB form a toxin-antitoxin system. RelE represses translation, probably through binding ribosomes. RelB stably binds RelE, presumably deactivating it.


Pssm-ID: 427796  Cd Length: 83  Bit Score: 47.53  E-value: 2.47e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 1695800599  6 LQIRMDEDLKNEAADLFDKMGMDLPTAIRVFLKRAVAEKAIPFEVREP 53
Cdd:pfam04221  4 ISARIDEDTKAEAYAVLEKMGLTPSQAVRLFLTKVADNKALPFDLRLP 51
PRK11235 PRK11235
type II toxin-antitoxin system RelB/DinJ family antitoxin;
1-48 1.17e-03

type II toxin-antitoxin system RelB/DinJ family antitoxin;


Pssm-ID: 183047  Cd Length: 80  Bit Score: 33.06  E-value: 1.17e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 1695800599  1 MATtvLQIRMDEDLKNEAADLFDKMGMDLPTAIRVFLKRAVAEKAIPF 48
Cdd:PRK11235   1 MAT--INVRVDDELKARAYAVLEKLGVTPSEALRLLLQYVAENGRLPF 46
 
Name Accession Description Interval E-value
RelB COG3077
Antitoxin component of the RelBE or YafQ-DinJ toxin-antitoxin module [Defense mechanisms];
1-53 1.31e-17

Antitoxin component of the RelBE or YafQ-DinJ toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442311  Cd Length: 82  Bit Score: 68.36  E-value: 1.31e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1695800599  1 MATTVLQIRMDEDLKNEAADLFDKMGMDLPTAIRVFLKRAVAEKAIPFEVREP 53
Cdd:COG3077    2 MATANVNVRIDEELKEEAEAVLEELGLTPSDAIRMFLKQVVREGGLPFELKLP 54
RelB_DinJ TIGR02384
addiction module antitoxin, RelB/DinJ family; Plasmids may be maintained stably in bacterial ...
 1-53 3.04e-16

addiction module antitoxin, RelB/DinJ family; Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all were found adjacent to toxin genes. The resulting model appears to describe a narrower set of proteins than pfam04221, although many in the scope of this model are not obviously paired with toxin proteins. Several toxin/antitoxin pairs may occur in a single species. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other]


Pssm-ID: 274102  Cd Length: 84  Bit Score: 65.03  E-value: 3.04e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1695800599  1 MATTVLQIRMDEDLKNEAADLFDKMGMDLPTAIRVFLKRAVAEKAIPFEVREP 53
Cdd:TIGR02384  1 MATATISIRIDEELKKEAYAVFEELGLTPSTAIRMFLKQVIREQGLPFDLRLP 53
RelB pfam04221
RelB antitoxin; RelE and RelB form a toxin-antitoxin system. RelE represses translation, ...
 6-53 2.47e-09

RelB antitoxin; RelE and RelB form a toxin-antitoxin system. RelE represses translation, probably through binding ribosomes. RelB stably binds RelE, presumably deactivating it.


Pssm-ID: 427796  Cd Length: 83  Bit Score: 47.53  E-value: 2.47e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 1695800599  6 LQIRMDEDLKNEAADLFDKMGMDLPTAIRVFLKRAVAEKAIPFEVREP 53
Cdd:pfam04221  4 ISARIDEDTKAEAYAVLEKMGLTPSQAVRLFLTKVADNKALPFDLRLP 51
PRK11235 PRK11235
type II toxin-antitoxin system RelB/DinJ family antitoxin;
1-48 1.17e-03

type II toxin-antitoxin system RelB/DinJ family antitoxin;


Pssm-ID: 183047  Cd Length: 80  Bit Score: 33.06  E-value: 1.17e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 1695800599  1 MATtvLQIRMDEDLKNEAADLFDKMGMDLPTAIRVFLKRAVAEKAIPF 48
Cdd:PRK11235   1 MAT--INVRVDDELKARAYAVLEKLGVTPSEALRLLLQYVAENGRLPF 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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