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Conserved domains on  [gi|1693805357|dbj|BBC12545|]
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Trp2 protein, partial [Tapinella sp. (in: Fungi)]

Protein Classification

anthranilate synthase component I family protein( domain architecture ID 1903281)

anthranilate synthase component I family protein similar to the component I of anthranilate synthase and aminodeoxychorismate synthase, which are part of complexes that catalyze the two-step biosynthesis of anthranilate and 4-amino-4-deoxychorismate (ADC), respectively

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrpE super family cl43039
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ...
 1-85 5.33e-45

Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


The actual alignment was detected with superfamily member COG0147:

Pssm-ID: 439917 [Multi-domain]  Cd Length: 416  Bit Score: 148.71  E-value: 5.33e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   1 ELQIVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDEL 80
Cdd:COG0147   212 DFAIVGSSPERLVRVEDGRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEHLMLVDLARNDLGRVCEPGSVKVPEL 291


                  ....*
gi 1693805357  81 MKLQK 85
Cdd:COG0147   292 MVVER 296
 
Name Accession Description Interval E-value
TrpE COG0147
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ...
 1-85 5.33e-45

Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439917 [Multi-domain]  Cd Length: 416  Bit Score: 148.71  E-value: 5.33e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   1 ELQIVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDEL 80
Cdd:COG0147   212 DFAIVGSSPERLVRVEDGRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEHLMLVDLARNDLGRVCEPGSVKVPEL 291


                  ....*
gi 1693805357  81 MKLQK 85
Cdd:COG0147   292 MVVER 296
TrpE-arch TIGR01820
anthranilate synthase component I, archaeal clade; This model represents an archaeal clade of ...
 1-85 5.20e-39

anthranilate synthase component I, archaeal clade; This model represents an archaeal clade of anthranilate synthase component I enzymes. This enzyme is responsible for the first step of tryptophan biosynthesis from chorismate. The Sulfolobus enzyme has been reported to be part of a gene cluster for Trp biosynthesis [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273819 [Multi-domain]  Cd Length: 435  Bit Score: 133.64  E-value: 5.20e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   1 ELQIVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDEL 80
Cdd:TIGR01820 232 DRYLVGSSPETLVRVEGRTVETNPIAGTRPRGATPEEDERLAKELLSDEKERAEHVMLVDLARNDVRKVSEPGSVKVPEF 311


                  ....*
gi 1693805357  81 MKLQK 85
Cdd:TIGR01820 312 MYVEK 316
Chorismate_bind pfam00425
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ...
 4-85 1.48e-36

chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.


Pssm-ID: 425674 [Multi-domain]  Cd Length: 255  Bit Score: 123.05  E-value: 1.48e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   4 IVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDELMKL 83
Cdd:pfam00425  64 FLGASPERLLSVDGGRIITEPIAGTRPRGKDPAEDEALAAELLADPKERAEHLMVVDLIRNDLGRVCVPGSVKVPELPEV 143


                  ..
gi 1693805357  84 QK 85
Cdd:pfam00425 144 ER 145
PRK13572 PRK13572
anthranilate synthase component I; Provisional
 4-85 1.03e-32

anthranilate synthase component I; Provisional


Pssm-ID: 237432 [Multi-domain]  Cd Length: 435  Bit Score: 116.76  E-value: 1.03e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   4 IVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDELMKL 83
Cdd:PRK13572  233 VVGASPETMASVENNILKINPIAGTAPRGKTEEEDKKLAEALLSDEKERAEHVMLVDLARNDVRKVSKSGSVRLERFFDV 312


                  ..
gi 1693805357  84 QK 85
Cdd:PRK13572  313 VK 314
 
Name Accession Description Interval E-value
TrpE COG0147
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ...
 1-85 5.33e-45

Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439917 [Multi-domain]  Cd Length: 416  Bit Score: 148.71  E-value: 5.33e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   1 ELQIVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDEL 80
Cdd:COG0147   212 DFAIVGSSPERLVRVEDGRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEHLMLVDLARNDLGRVCEPGSVKVPEL 291


                  ....*
gi 1693805357  81 MKLQK 85
Cdd:COG0147   292 MVVER 296
TrpE-arch TIGR01820
anthranilate synthase component I, archaeal clade; This model represents an archaeal clade of ...
 1-85 5.20e-39

anthranilate synthase component I, archaeal clade; This model represents an archaeal clade of anthranilate synthase component I enzymes. This enzyme is responsible for the first step of tryptophan biosynthesis from chorismate. The Sulfolobus enzyme has been reported to be part of a gene cluster for Trp biosynthesis [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273819 [Multi-domain]  Cd Length: 435  Bit Score: 133.64  E-value: 5.20e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   1 ELQIVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDEL 80
Cdd:TIGR01820 232 DRYLVGSSPETLVRVEGRTVETNPIAGTRPRGATPEEDERLAKELLSDEKERAEHVMLVDLARNDVRKVSEPGSVKVPEF 311


                  ....*
gi 1693805357  81 MKLQK 85
Cdd:TIGR01820 312 MYVEK 316
trpE_most TIGR00564
anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some ...
 3-85 3.74e-38

anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. Archaeal enzymes have been excluded from this model (and are now found in TIGR01820) as have a clade of enzymes which constitute a TrpE paralog which may have PabB activity (TIGR01824). This allows the B. subtilus paralog which has been shown to have PabB activity to score below trusted to this model. This model contains sequences from gram-positive bacteria, certain proteobacteria, cyanobacteria, plants, fungi and assorted other bacteria.A second family of TrpE enzymes is modelled by TIGR00565. The breaking of the TrpE family into these diverse models allows for the separation of the models for the related enzyme, PabB. [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273142 [Multi-domain]  Cd Length: 454  Bit Score: 131.69  E-value: 3.74e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   3 QIVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDELMK 82
Cdd:TIGR00564 253 QIVGSSPELLVKVTGGRITTRPIAGTRKRGATPEEDEALAEELLADEKERAEHLMLVDLGRNDIGRVCEPGSVEVPEFMK 332


                  ...
gi 1693805357  83 LQK 85
Cdd:TIGR00564 333 IER 335
Chorismate_bind pfam00425
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ...
 4-85 1.48e-36

chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.


Pssm-ID: 425674 [Multi-domain]  Cd Length: 255  Bit Score: 123.05  E-value: 1.48e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   4 IVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDELMKL 83
Cdd:pfam00425  64 FLGASPERLLSVDGGRIITEPIAGTRPRGKDPAEDEALAAELLADPKERAEHLMVVDLIRNDLGRVCVPGSVKVPELPEV 143


                  ..
gi 1693805357  84 QK 85
Cdd:pfam00425 144 ER 145
PRK13572 PRK13572
anthranilate synthase component I; Provisional
 4-85 1.03e-32

anthranilate synthase component I; Provisional


Pssm-ID: 237432 [Multi-domain]  Cd Length: 435  Bit Score: 116.76  E-value: 1.03e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   4 IVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDELMKL 83
Cdd:PRK13572  233 VVGASPETMASVENNILKINPIAGTAPRGKTEEEDKKLAEALLSDEKERAEHVMLVDLARNDVRKVSKSGSVRLERFFDV 312


                  ..
gi 1693805357  84 QK 85
Cdd:PRK13572  313 VK 314
PRK13571 PRK13571
anthranilate synthase component I; Provisional
 4-85 2.83e-32

anthranilate synthase component I; Provisional


Pssm-ID: 184152 [Multi-domain]  Cd Length: 506  Bit Score: 116.28  E-value: 2.83e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   4 IVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDELMKL 83
Cdd:PRK13571  297 IVGSSPEALVTVTDGRATTHPIAGTRWRGATPEEDALLEKELLADPKERAEHLMLVDLGRNDLGRVCRPGTVRVVDFSHI 376


                  ..
gi 1693805357  84 QK 85
Cdd:PRK13571  377 ER 378
PRK05940 PRK05940
anthranilate synthase component I;
4-85 4.33e-31

anthranilate synthase component I;


Pssm-ID: 235651 [Multi-domain]  Cd Length: 463  Bit Score: 112.51  E-value: 4.33e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   4 IVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDELMKL 83
Cdd:PRK05940  251 VVSCSPERLVQLQGNQAQTRPIAGTRPRGKTPAEDQQLAEELLSNIKERAEHIMLVDLERNDLGRVCQWGSVEVDELLTI 330


                  ..
gi 1693805357  84 QK 85
Cdd:PRK05940  331 ER 332
PRK13574 PRK13574
anthranilate synthase component I; Provisional
 1-85 1.96e-30

anthranilate synthase component I; Provisional


Pssm-ID: 184155 [Multi-domain]  Cd Length: 420  Bit Score: 110.29  E-value: 1.96e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   1 ELQIVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDEL 80
Cdd:PRK13574  216 ERYLIGSSPELLFRVQDNIVETYPIAGTRPRGSDQEEDLKLELELMNSEKDKAEHLMLVDLARNDLGKVCVPGTVRVPEL 295


                  ....*
gi 1693805357  81 MKLQK 85
Cdd:PRK13574  296 MYVEK 300
PLN02445 PLN02445
anthranilate synthase component I
 4-85 8.30e-30

anthranilate synthase component I


Pssm-ID: 215244 [Multi-domain]  Cd Length: 523  Bit Score: 109.77  E-value: 8.30e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   4 IVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDELMKL 83
Cdd:PLN02445  297 LVASSPEILTRVKKNKIVNRPLAGTRRRGKTPEEDKALEKDLLADEKQCAEHIMLVDLGRNDVGKVSKAGSVKVEKLMNI 376


                  ..
gi 1693805357  84 QK 85
Cdd:PLN02445  377 ER 378
PabB-clade2 TIGR01824
aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely ...
 4-85 6.19e-28

aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely related to TrpE (anthranilate synthase, TIGR00564/TIGR01820/TIGR00565) than to the better characterized group of PabB enzymes (TIGR00553/TIGR01823). This clade includes one characterized enzyme from Lactococcus and the conserved function across the clade is supported by these pieces of evidence: 1) all genomes with a member in this clade also have a separate TrpE gene, 2) none of these genomes contain an aparrent PabB from any of the other PabB clades, 3) none of these sequences are found in a region of the genome in association with other Trp biosynthesis genes, 4) all of these genomes aparrently contain most if not all of the steps of the folate biosynthetic pathway (for which PABA is a precursor). Many of the sequences hit by this model are annotated as TrpE enzymes, however, we believe that all members of this clade are, in fact, PabB. The sequences from Bacillus halodurans and subtilus which score below the trusted cutoff for this model are also likely to be PabB enzymes, but are too closely related to TrpE to be separated at this time.


Pssm-ID: 130883  Cd Length: 355  Bit Score: 102.93  E-value: 6.19e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   4 IVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDELMKL 83
Cdd:TIGR01824 160 VASASPELFLAREGRVVQTRPIAGTRPRGATLAEDGALAAELLQHDKDRAEHVMIVDLERNDLGRVCATGTVRVPELCAV 239


                  ..
gi 1693805357  84 QK 85
Cdd:TIGR01824 240 ES 241
PRK09070 PRK09070
aminodeoxychorismate synthase component I;
3-84 1.26e-26

aminodeoxychorismate synthase component I;


Pssm-ID: 236371 [Multi-domain]  Cd Length: 447  Bit Score: 100.55  E-value: 1.26e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   3 QIVGASPETLCKVENNKVYNHAIAGTTKRGKSSEeDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDELMK 82
Cdd:PRK09070  245 AIVSSSPERLVSVQGGVVQTRPIAGTRPRFAGDD-DAALIRELVGHPKERAEHVMLIDLERNDLGRICAPGSVEVDELMT 323


                  ..
gi 1693805357  83 LQ 84
Cdd:PRK09070  324 VE 325
PRK13567 PRK13567
anthranilate synthase component I; Provisional
 4-85 2.34e-23

anthranilate synthase component I; Provisional


Pssm-ID: 184148 [Multi-domain]  Cd Length: 468  Bit Score: 91.36  E-value: 2.34e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   4 IVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDELMKL 83
Cdd:PRK13567  268 IVGSSPESFVSVKDQIVTTNPIAGTIQRGETTQIDNENMKQLLNDPKECSEHRMLVDLGRNDIHRVSKIGTSKITKLMVI 347


                  ..
gi 1693805357  84 QK 85
Cdd:PRK13567  348 EK 349
PRK13564 PRK13564
anthranilate synthase component 1;
6-82 2.85e-21

anthranilate synthase component 1;


Pssm-ID: 237428 [Multi-domain]  Cd Length: 520  Bit Score: 85.66  E-value: 2.85e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   6 GASPETLCKVE--NNKVYNHAIAGTTKRGKSS--EEDRQLGEK----LLSSNKDRAEHIMLVDLARNDVNRVCRPETVKV 77
Cdd:PRK13564  305 GASPESALKYDasSRQVEIYPIAGTRPRGRRAdgSIDRDLDSRieleLRTDHKELAEHLMLVDLARNDLARICQPGSRYV 384


                  ....*
gi 1693805357  78 DELMK 82
Cdd:PRK13564  385 ADLLK 389
MenF COG1169
Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites ...
 5-83 4.74e-19

Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; Isochorismate synthase EntC is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440783 [Multi-domain]  Cd Length: 353  Bit Score: 79.04  E-value: 4.74e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   5 VGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHimlvDLARNDVNRVCRP--ETVKVDE--- 79
Cdd:COG1169   154 VGASPERLVRRRGGQLTTEALAGTAPRGADPEEDAALAAALLASEKDRREH----ALVVDSIREALAPlcSSLDVPEepe 229


                  ....
gi 1693805357  80 LMKL 83
Cdd:COG1169   230 LLRL 233
pabB PRK15465
aminodeoxychorismate synthase component 1;
4-80 1.00e-18

aminodeoxychorismate synthase component 1;


Pssm-ID: 185362 [Multi-domain]  Cd Length: 453  Bit Score: 78.42  E-value: 1.00e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1693805357   4 IVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDEL 80
Cdd:PRK15465  252 ILSLSPERFILCDNSEIQTRPIKGTLPRLPDPQEDSKQAEKLANSAKDRAENLMIVDLMRNDIGRVAVAGSVKVPEL 328
PRK06404 PRK06404
anthranilate synthase component I; Reviewed
 3-85 1.43e-18

anthranilate synthase component I; Reviewed


Pssm-ID: 102361 [Multi-domain]  Cd Length: 351  Bit Score: 77.60  E-value: 1.43e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   3 QIVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEdrqlgekLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDELMK 82
Cdd:PRK06404  163 RVVGSSPENVFTVNGNIINVDPIAGTYDDKILSNE-------LLNSEKDKLEHRMLLDLARNDLSKFADIGTLNVDKVMK 235


                  ...
gi 1693805357  83 LQK 85
Cdd:PRK06404  236 IEE 238
PLN02889 PLN02889
oxo-acid-lyase/anthranilate synthase
 2-84 5.73e-18

oxo-acid-lyase/anthranilate synthase


Pssm-ID: 215481 [Multi-domain]  Cd Length: 918  Bit Score: 76.43  E-value: 5.73e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   2 LQIVGASPETLCKVENNKVYN-HAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDEL 80
Cdd:PLN02889  706 LCICSSSPERFLKLDRNGMLEaKPIKGTIARGSTPEEDEQLKLQLQYSEKDQAENLMIVDLLRNDLGRVCEPGSVHVPNL 785


                  ....
gi 1693805357  81 MKLQ 84
Cdd:PLN02889  786 MDVE 789
PRK07508 PRK07508
aminodeoxychorismate synthase component I;
4-84 8.65e-18

aminodeoxychorismate synthase component I;


Pssm-ID: 236035 [Multi-domain]  Cd Length: 378  Bit Score: 75.43  E-value: 8.65e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   4 IVGASPETLCKV-ENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDELMK 82
Cdd:PRK07508  173 ILSRSPELFFRVdGEGWIETHPMKGTAPRGATPAEDARLRAALLNDEKNQAENRMIVDLLRNDISRISEVGSLDVPELFD 252


                  ..
gi 1693805357  83 LQ 84
Cdd:PRK07508  253 IE 254
PRK07054 PRK07054
isochorismate synthase;
5-84 9.32e-18

isochorismate synthase;


Pssm-ID: 235920 [Multi-domain]  Cd Length: 475  Bit Score: 75.96  E-value: 9.32e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   5 VGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCR----PETVKVDEL 80
Cdd:PRK07054  259 LGATPERLVRVAAGDLHTHALAGTIARGADPAEDARLGAALMASAKDRLEHALVVDAIRAALAPLSRaldiPDQPSLHRL 338


                  ....
gi 1693805357  81 MKLQ 84
Cdd:PRK07054  339 PRLQ 342
isochor_syn TIGR00543
isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, ...
 5-84 1.54e-17

isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, different loci encode isochorismate synthases for the pathways of menaquinone biosynthesis and enterobactin biosynthesis (via salicilate) and fail to complement each other. Among isochorismate synthases, the N-terminal domain is poorly conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273127  Cd Length: 351  Bit Score: 74.71  E-value: 1.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   5 VGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCR----PETVKVDEL 80
Cdd:TIGR00543 155 LGATPERLLSREKGELLTEALAGTAPRSADPEEDRKLGELLLKDDKNLREHRLVVEYIRRRLQPICTsldvSETPELLKL 234


                  ....
gi 1693805357  81 MKLQ 84
Cdd:TIGR00543 235 ANVQ 238
PRK13566 PRK13566
anthranilate synthase component I;
4-77 3.59e-17

anthranilate synthase component I;


Pssm-ID: 237429 [Multi-domain]  Cd Length: 720  Bit Score: 74.18  E-value: 3.59e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1693805357   4 IVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKV 77
Cdd:PRK13566  306 LVGASPEMFVRVEGRRVETCPISGTIKRGADAIGDAEQIRKLLNSKKDESELTMCTDVDRNDKSRVCEPGSVKV 379
PRK05877 PRK05877
aminodeoxychorismate synthase component I; Provisional
 4-84 2.16e-12

aminodeoxychorismate synthase component I; Provisional


Pssm-ID: 235634 [Multi-domain]  Cd Length: 405  Bit Score: 60.49  E-value: 2.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   4 IVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEdrqlgekLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDELMKL 83
Cdd:PRK05877  203 VASLSPELFLRRRGSVVTSSPIKGTLPLDADPSA-------LRASAKDVAENIMIVDLVRNDLGRVARTGTVTVPELLVV 275


                  .
gi 1693805357  84 Q 84
Cdd:PRK05877  276 R 276
PRK07093 PRK07093
para-aminobenzoate synthase component I; Validated
 8-78 8.08e-12

para-aminobenzoate synthase component I; Validated


Pssm-ID: 235932 [Multi-domain]  Cd Length: 323  Bit Score: 58.73  E-value: 8.08e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1693805357   8 SPETLCKVENNKVYNHAIAGTTKrgkSSEEDRQlgEKLLSSNKDRAEHIMLVDLARNDVNRVCrpETVKVD 78
Cdd:PRK07093  132 SPEPFVRIEDNKISTYPMKGTID---ASLPNAE--EKLLNDEKEFAEHATIVDLLRNDLSMVA--KNVRVT 195
PRK06772 PRK06772
salicylate synthase;
3-85 1.24e-09

salicylate synthase;


Pssm-ID: 102546 [Multi-domain]  Cd Length: 434  Bit Score: 52.82  E-value: 1.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   3 QIVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDELMK 82
Cdd:PRK06772  233 EALGFSPELVMSVTGNKVVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIAELEAVCQPGSVVVEDLMS 312


                  ...
gi 1693805357  83 LQK 85
Cdd:PRK06772  313 VRQ 315
PRK15016 PRK15016
isochorismate synthase EntC; Provisional
 4-68 2.27e-08

isochorismate synthase EntC; Provisional


Pssm-ID: 184977 [Multi-domain]  Cd Length: 391  Bit Score: 49.10  E-value: 2.27e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1693805357   4 IVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHiMLVDLARNDVNR 68
Cdd:PRK15016  191 LLGASPELLLRKDGERFSSLPLAGSARRQPDEVLDREAGNRLLASEKDRHEH-ELVTQAMKEVLR 254
PRK06923 PRK06923
isochorismate synthase DhbC; Validated
 4-71 4.69e-08

isochorismate synthase DhbC; Validated


Pssm-ID: 235886 [Multi-domain]  Cd Length: 399  Bit Score: 48.19  E-value: 4.69e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1693805357   4 IVGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCR 71
Cdd:PRK06923  191 LIGASPELLVSRHGMQVISNPLAGSRPRSDDPVEDKRRAEELLSSPKDLHEHAVVVEAVAAALRPYCH 258
PLN02786 PLN02786
isochorismate synthase
 5-77 9.84e-08

isochorismate synthase


Pssm-ID: 178383 [Multi-domain]  Cd Length: 533  Bit Score: 47.47  E-value: 9.84e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1693805357   5 VGASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCrpETVKV 77
Cdd:PLN02786  327 IGNTPEQLFHRKGLGVCSEALAATRPRGGSSARDLQIELDLLTSPKDDLEFSIVRENIREKLEAIC--DRVVV 397
PRK07912 PRK07912
salicylate synthase;
2-81 1.59e-04

salicylate synthase;


Pssm-ID: 169151 [Multi-domain]  Cd Length: 449  Bit Score: 38.23  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1693805357   2 LQIVGASPETLCKVENNK-VYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVDLARNDVNRVCRPETVKVDEL 80
Cdd:PRK07912  243 IRALGYSPELVTAVRADGvVITEPLAGTRAFGRGAAIDRLARDDLESNSKEIVEHAISVRSSLAEITEIAEPGSAAVIDF 322


                  .
gi 1693805357  81 M 81
Cdd:PRK07912  323 M 323
PRK15012 PRK15012
menaquinone-specific isochorismate synthase; Provisional
 6-60 1.00e-03

menaquinone-specific isochorismate synthase; Provisional


Pssm-ID: 184974 [Multi-domain]  Cd Length: 431  Bit Score: 35.97  E-value: 1.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1693805357   6 GASPETLCKVENNKVYNHAIAGTTKRGKSSEEDRQLGEKLLSSNKDRAEHIMLVD 60
Cdd:PRK15012  236 GSSPERLWRRRDKALRTEALAGTVANHPDDKQAQQLGEWLMADDKNQRENMLVVE 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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