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Conserved domains on  [gi|169293996|gb|EDS76129|]
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hypothetical protein CLOSPI_00094 [[Clostridium] spiroforme DSM 1552]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 193-264 5.38e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 48.45  E-value: 5.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169293996 193 EKATEKLADKNVKVT-HLTDDGKLPFKDERLDVVVS-----ELANYDRY--DLYRVVKPGGYILVDQMGSDNYREIMNIF 264
Cdd:COG2226   58 ELARERAAEAGLNVEfVVGDAEDLPFPDGSFDLVISsfvlhHLPDPERAlaEIARVLKPGGRLVVVDFSPPDLAELEELL 137
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 193-264 5.38e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 48.45  E-value: 5.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169293996 193 EKATEKLADKNVKVT-HLTDDGKLPFKDERLDVVVS-----ELANYDRY--DLYRVVKPGGYILVDQMGSDNYREIMNIF 264
Cdd:COG2226   58 ELARERAAEAGLNVEfVVGDAEDLPFPDGSFDLVISsfvlhHLPDPERAlaEIARVLKPGGRLVVVDFSPPDLAELEELL 137
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 171-249 8.78e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 43.81  E-value: 8.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169293996  171 GGEFISSFDKLPPITYVV---ESQYEKATEKLADKNVKVtHLTDDGKLPFKDERLDVVVSELANY---DRYD----LYRV 240
Cdd:pfam08241   7 TGLLTELLARLGARVTGVdisPEMLELAREKAPREGLTF-VVGDAEDLPFPDNSFDLVLSSEVLHhveDPERalreIARV 85


                  ....*....
gi 169293996  241 VKPGGYILV 249
Cdd:pfam08241  86 LKPGGILII 94
PRK08317 PRK08317
hypothetical protein; Provisional
 195-249 2.19e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 45.31  E-value: 2.19e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 169293996 195 ATEKLADKNVKV-THLTDDGKLPFKDERLDVVVSE-----LANYDRY--DLYRVVKPGGYILV 249
Cdd:PRK08317  60 AKERAAGLGPNVeFVRGDADGLPFPDGSFDAVRSDrvlqhLEDPARAlaEIARVLRPGGRVVV 122
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 193-264 5.38e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 48.45  E-value: 5.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169293996 193 EKATEKLADKNVKVT-HLTDDGKLPFKDERLDVVVS-----ELANYDRY--DLYRVVKPGGYILVDQMGSDNYREIMNIF 264
Cdd:COG2226   58 ELARERAAEAGLNVEfVVGDAEDLPFPDGSFDLVISsfvlhHLPDPERAlaEIARVLKPGGRLVVVDFSPPDLAELEELL 137
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 171-249 8.78e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 43.81  E-value: 8.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169293996  171 GGEFISSFDKLPPITYVV---ESQYEKATEKLADKNVKVtHLTDDGKLPFKDERLDVVVSELANY---DRYD----LYRV 240
Cdd:pfam08241   7 TGLLTELLARLGARVTGVdisPEMLELAREKAPREGLTF-VVGDAEDLPFPDNSFDLVLSSEVLHhveDPERalreIARV 85


                  ....*....
gi 169293996  241 VKPGGYILV 249
Cdd:pfam08241  86 LKPGGILII 94
PRK08317 PRK08317
hypothetical protein; Provisional
 195-249 2.19e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 45.31  E-value: 2.19e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 169293996 195 ATEKLADKNVKV-THLTDDGKLPFKDERLDVVVSE-----LANYDRY--DLYRVVKPGGYILV 249
Cdd:PRK08317  60 AKERAAGLGPNVeFVRGDADGLPFPDGSFDAVRSDrvlqhLEDPARAlaEIARVLRPGGRVVV 122
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 193-245 4.30e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 41.78  E-value: 4.30e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 169293996  193 EKATEKLADKNVKVTHLTDDG-KLPFKDERLDVVVS-----ELANYDRYD----LYRVVKPGG 245
Cdd:pfam13649  34 ERARERAAEAGLNVEFVQGDAeDLPFPDGSFDLVVSsgvlhHLPDPDLEAalreIARVLKPGG 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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