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Conserved domains on  [gi|169234947|ref|NP_033999|]
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cadherin-9 preproprotein [Mus musculus]

Protein Classification

cadherin( domain architecture ID 10182681)

cadherin is a calcium-dependent cell adhesion protein that preferentially interacts with itself in a homophilic manner in connecting cells; it plays a crucial role in tissue morphogenesis and homeostasis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 722-781 2.13e-34

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 124.96  E-value: 2.13e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947  722 NDSDPSAPPYDSLATYAYEGNDSVANSLSSLESLTADCNQDYDYLSDWGPRFKKLAEMYG 781
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 163-263 1.06e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.10  E-value: 1.06e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947 163 YTASVPEMSGVGTSVIQVTATDADDanyGNSAKVVYSILQGQP--YFSVDPESGIIKTALPdMSRENKEQYQVVIQAKDM 240
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|...
gi 169234947 241 GGQmgGLSGTTTVNITLTDVNNN 263
Cdd:cd11304   78 GGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 386-483 4.39e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 4.39e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947 386 SYLMEVDEDVKEGSIIGQVTAYDPDA-MNNIIKYSVDRHTDmDRVFSIHSENGSIFTLKPLDRESSPWHNITITATEINN 464
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 169234947 465 PKQSSQIPVFIRILDINDH 483
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 271-378 4.45e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 4.45e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947 271 TYQFNSLESAPLGTHLGRIKANDPDMGENAELEYSIAEGEGSDMFDVitdkDTQEGIITVKQNLDFEKKMLYTLRVDASN 350
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|....*...
gi 169234947 351 THPDPRFlhlgpfkDSAMVKISVEDVDE 378
Cdd:cd11304   77 GGGPPLS-------STATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 71-154 2.49e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.74  E-value: 2.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947  71 QYVGKLH-TDQDKGD-GNLKYILTGDGAGNLFVIDENTGDIHAAKRLDREEKSLYILRAKAIDRKTGRQvEPESEFIIKI 148
Cdd:cd11304   14 TVVLTVSaTDPDSGEnGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL-SSTATVTITV 92


                 ....*.
gi 169234947 149 HDINDN 154
Cdd:cd11304   93 LDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 491-588 4.04e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 4.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947 491 YETFVCENAKSGQLIQTISVMDKDDPPRGH-KFFFEPVPEFPLnpnFTIvdnkDNTAGIVTRKDGYSRNKMNTYLLPVLI 569
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEvTYSIVSGNEDGL---FSI----DPSTGEITTAKPLDREEQSSYTLTVTA 74

                         90
                 ....*....|....*....
gi 169234947 570 FDNDYPIQSSTGTLTIRVC 588
Cdd:cd11304   75 TDGGGPPLSSTATVTITVL 93
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 722-781 2.13e-34

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 124.96  E-value: 2.13e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947  722 NDSDPSAPPYDSLATYAYEGNDSVANSLSSLESLTADCNQDYDYLSDWGPRFKKLAEMYG 781
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 163-263 1.06e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.10  E-value: 1.06e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947 163 YTASVPEMSGVGTSVIQVTATDADDanyGNSAKVVYSILQGQP--YFSVDPESGIIKTALPdMSRENKEQYQVVIQAKDM 240
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|...
gi 169234947 241 GGQmgGLSGTTTVNITLTDVNNN 263
Cdd:cd11304   78 GGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 386-483 4.39e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 4.39e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947 386 SYLMEVDEDVKEGSIIGQVTAYDPDA-MNNIIKYSVDRHTDmDRVFSIHSENGSIFTLKPLDRESSPWHNITITATEINN 464
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 169234947 465 PKQSSQIPVFIRILDINDH 483
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 271-378 4.45e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 4.45e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947 271 TYQFNSLESAPLGTHLGRIKANDPDMGENAELEYSIAEGEGSDMFDVitdkDTQEGIITVKQNLDFEKKMLYTLRVDASN 350
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|....*...
gi 169234947 351 THPDPRFlhlgpfkDSAMVKISVEDVDE 378
Cdd:cd11304   77 GGGPPLS-------STATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 181-265 6.54e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 6.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947   181 TATDADDanyGNSAKVVYSILQG--QPYFSVDPESGIIKTALPdMSRENKEQYQVVIQAKDMGGQmgGLSGTTTVNITLT 258
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   ....*..
gi 169234947   259 DVNNNPP 265
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
163-258 1.61e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.59  E-value: 1.61e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947  163 YTASVPEMSGVGTSVIQVTATDADDanyGNSAKVVYSILQGQPY--FSVDPESGIIKTALPdMSRENKEQYQVVIQAKDM 240
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGDISTTKP-LDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*...
gi 169234947  241 GGQmgGLSGTTTVNITLT 258
Cdd:pfam00028  77 GGP--PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 405-485 1.35e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 1.35e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947   405 TAYDPDA-MNNIIKYSVDRHTDmDRVFSIHSENGSIFTLKPLDRESSPWHNITITATEINNPKQSSQIPVFIRILDINDH 483
Cdd:smart00112   1 SATDADSgENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 169234947   484 AP 485
Cdd:smart00112  80 AP 81
Cadherin pfam00028
Cadherin domain;
387-478 8.09e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 8.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947  387 YLMEVDEDVKEGSIIGQVTAYDPD-AMNNIIKYSVDRHtDMDRVFSIHSENGSIFTLKPLDRESSPWHNITITATEINNP 465
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDlGPNGRIFYSILGG-GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 169234947  466 KQSSQIPVFIRIL 478
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 71-154 2.49e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.74  E-value: 2.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947  71 QYVGKLH-TDQDKGD-GNLKYILTGDGAGNLFVIDENTGDIHAAKRLDREEKSLYILRAKAIDRKTGRQvEPESEFIIKI 148
Cdd:cd11304   14 TVVLTVSaTDPDSGEnGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL-SSTATVTITV 92


                 ....*.
gi 169234947 149 HDINDN 154
Cdd:cd11304   93 LDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 78-156 6.42e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 6.42e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947    78 TDQDKGD-GNLKYILTGDGAGNLFVIDENTGDIHAAKRLDREEKSLYILRAKAIDRkTGRQVEPESEFIIKIHDINDNEP 156
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDG-GGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
272-374 2.47e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 2.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947  272 YQFNSLESAPLGTHLGRIKANDPDMGENAELEYSIAEGEGSDMFDVitdkDTQEGIITVKQNLDFEKKMLYTLRVDASNT 351
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 169234947  352 HPDPRFlhlgpfkDSAMVKISVE 374
Cdd:pfam00028  77 GGPPLS-------STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 290-380 1.83e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 1.83e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947   290 KANDPDMGENAELEYSIAEGEGSDMFDVitdkDTQEGIITVKQNLDFEKKMLYTLRVDASNTHPDPRflhlgpfKDSAMV 369
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL-------SSTATV 69

                           90
                   ....*....|..
gi 169234947   370 KISVEDV-DEPP 380
Cdd:smart00112  70 TITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
78-132 1.83e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.78  E-value: 1.83e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 169234947   78 TDQDKGD-GNLKYILTGDGAGNLFVIDENTGDIHAAKRLDREEKSLYILRAKAIDR 132
Cdd:pfam00028  21 TDPDLGPnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 491-588 4.04e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 4.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947 491 YETFVCENAKSGQLIQTISVMDKDDPPRGH-KFFFEPVPEFPLnpnFTIvdnkDNTAGIVTRKDGYSRNKMNTYLLPVLI 569
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEvTYSIVSGNEDGL---FSI----DPSTGEITTAKPLDREEQSSYTLTVTA 74

                         90
                 ....*....|....*....
gi 169234947 570 FDNDYPIQSSTGTLTIRVC 588
Cdd:cd11304   75 TDGGGPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
491-588 7.01e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.24  E-value: 7.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947  491 YETFVCENAKSGQLIQTISVMDKDDPPRGHKFFFEpVPEFPLNpNFTIvdNKDnTAGIVTRK--DgysRNKMNTYLLPVL 568
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI-LGGGPGG-NFRI--DPD-TGDISTTKplD---RESIGEYELTVE 72

                          90       100
                  ....*....|....*....|
gi 169234947  569 IFDNDYPIQSSTGTLTIRVC 588
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 509-588 9.06e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.57  E-value: 9.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947   509 SVMDKDDPPRGhKFFFEPVPEFPLNPnFTIvdnkDNTAGIVTRKDGYSRNKMNTYLLPVLIFDNDYPIQSSTGTLTIRVC 588
Cdd:smart00112   1 SATDADSGENG-KVTYSILSGNDDGL-FSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 722-781 2.13e-34

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 124.96  E-value: 2.13e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947  722 NDSDPSAPPYDSLATYAYEGNDSVANSLSSLESLTADCNQDYDYLSDWGPRFKKLAEMYG 781
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 163-263 1.06e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.10  E-value: 1.06e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947 163 YTASVPEMSGVGTSVIQVTATDADDanyGNSAKVVYSILQGQP--YFSVDPESGIIKTALPdMSRENKEQYQVVIQAKDM 240
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|...
gi 169234947 241 GGQmgGLSGTTTVNITLTDVNNN 263
Cdd:cd11304   78 GGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 386-483 4.39e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 4.39e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947 386 SYLMEVDEDVKEGSIIGQVTAYDPDA-MNNIIKYSVDRHTDmDRVFSIHSENGSIFTLKPLDRESSPWHNITITATEINN 464
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSgENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 169234947 465 PKQSSQIPVFIRILDINDH 483
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 271-378 4.45e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 4.45e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947 271 TYQFNSLESAPLGTHLGRIKANDPDMGENAELEYSIAEGEGSDMFDVitdkDTQEGIITVKQNLDFEKKMLYTLRVDASN 350
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|....*...
gi 169234947 351 THPDPRFlhlgpfkDSAMVKISVEDVDE 378
Cdd:cd11304   77 GGGPPLS-------STATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 181-265 6.54e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 6.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947   181 TATDADDanyGNSAKVVYSILQG--QPYFSVDPESGIIKTALPdMSRENKEQYQVVIQAKDMGGQmgGLSGTTTVNITLT 258
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   ....*..
gi 169234947   259 DVNNNPP 265
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
163-258 1.61e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.59  E-value: 1.61e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947  163 YTASVPEMSGVGTSVIQVTATDADDanyGNSAKVVYSILQGQPY--FSVDPESGIIKTALPdMSRENKEQYQVVIQAKDM 240
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDL---GPNGRIFYSILGGGPGgnFRIDPDTGDISTTKP-LDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*...
gi 169234947  241 GGQmgGLSGTTTVNITLT 258
Cdd:pfam00028  77 GGP--PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 405-485 1.35e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 1.35e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947   405 TAYDPDA-MNNIIKYSVDRHTDmDRVFSIHSENGSIFTLKPLDRESSPWHNITITATEINNPKQSSQIPVFIRILDINDH 483
Cdd:smart00112   1 SATDADSgENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 169234947   484 AP 485
Cdd:smart00112  80 AP 81
Cadherin pfam00028
Cadherin domain;
387-478 8.09e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 8.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947  387 YLMEVDEDVKEGSIIGQVTAYDPD-AMNNIIKYSVDRHtDMDRVFSIHSENGSIFTLKPLDRESSPWHNITITATEINNP 465
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDlGPNGRIFYSILGG-GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 169234947  466 KQSSQIPVFIRIL 478
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 71-154 2.49e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.74  E-value: 2.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947  71 QYVGKLH-TDQDKGD-GNLKYILTGDGAGNLFVIDENTGDIHAAKRLDREEKSLYILRAKAIDRKTGRQvEPESEFIIKI 148
Cdd:cd11304   14 TVVLTVSaTDPDSGEnGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL-SSTATVTITV 92


                 ....*.
gi 169234947 149 HDINDN 154
Cdd:cd11304   93 LDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 78-156 6.42e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 6.42e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947    78 TDQDKGD-GNLKYILTGDGAGNLFVIDENTGDIHAAKRLDREEKSLYILRAKAIDRkTGRQVEPESEFIIKIHDINDNEP 156
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDG-GGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
272-374 2.47e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 2.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947  272 YQFNSLESAPLGTHLGRIKANDPDMGENAELEYSIAEGEGSDMFDVitdkDTQEGIITVKQNLDFEKKMLYTLRVDASNT 351
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90       100
                  ....*....|....*....|...
gi 169234947  352 HPDPRFlhlgpfkDSAMVKISVE 374
Cdd:pfam00028  77 GGPPLS-------STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 290-380 1.83e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 1.83e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947   290 KANDPDMGENAELEYSIAEGEGSDMFDVitdkDTQEGIITVKQNLDFEKKMLYTLRVDASNTHPDPRflhlgpfKDSAMV 369
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL-------SSTATV 69

                           90
                   ....*....|..
gi 169234947   370 KISVEDV-DEPP 380
Cdd:smart00112  70 TITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
78-132 1.83e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.78  E-value: 1.83e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 169234947   78 TDQDKGD-GNLKYILTGDGAGNLFVIDENTGDIHAAKRLDREEKSLYILRAKAIDR 132
Cdd:pfam00028  21 TDPDLGPnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 491-588 4.04e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.02  E-value: 4.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947 491 YETFVCENAKSGQLIQTISVMDKDDPPRGH-KFFFEPVPEFPLnpnFTIvdnkDNTAGIVTRKDGYSRNKMNTYLLPVLI 569
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEvTYSIVSGNEDGL---FSI----DPSTGEITTAKPLDREEQSSYTLTVTA 74

                         90
                 ....*....|....*....
gi 169234947 570 FDNDYPIQSSTGTLTIRVC 588
Cdd:cd11304   75 TDGGGPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
491-588 7.01e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.24  E-value: 7.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947  491 YETFVCENAKSGQLIQTISVMDKDDPPRGHKFFFEpVPEFPLNpNFTIvdNKDnTAGIVTRK--DgysRNKMNTYLLPVL 568
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI-LGGGPGG-NFRI--DPD-TGDISTTKplD---RESIGEYELTVE 72

                          90       100
                  ....*....|....*....|
gi 169234947  569 IFDNDYPIQSSTGTLTIRVC 588
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 71-154 3.45e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 43.49  E-value: 3.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947  71 QYVGKLHTDQDKGDGNLKYILtgdGAGN-----LFVIDENTGDIHAAKRLDREEKSLYILRAKAIdRKTGRQVEPESEFI 145
Cdd:cd00031   14 SFRVSIPTDLIASSGEIIKIS---AAGKealpsWLHWEPHSGILEGLEKLDREDKGVHYISVSAA-SLGANVPQTSSVFS 89


                 ....*....
gi 169234947 146 IKIHDINDN 154
Cdd:cd00031   90 IEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 509-588 9.06e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.57  E-value: 9.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234947   509 SVMDKDDPPRGhKFFFEPVPEFPLNPnFTIvdnkDNTAGIVTRKDGYSRNKMNTYLLPVLIFDNDYPIQSSTGTLTIRVC 588
Cdd:smart00112   1 SATDADSGENG-KVTYSILSGNDDGL-FSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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