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Conserved domains on  [gi|168812389|gb|ACA30333|]
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NADH dehydrogenase subunit 4, partial (mitochondrion) [Eulemur rufus]

Protein Classification

proton-conducting transporter membrane subunit( domain architecture ID 1562513)

proton-conducting transporter membrane subunit such as NADH dehydrogenase subunit 2, 4, or N, which shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain

EC:  7.1.-.-
Gene Ontology:  GO:0005886

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Proton_antipo_M super family cl39059
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-186 8.54e-119

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


The actual alignment was detected with superfamily member MTH00110:

Pssm-ID: 476862 [Multi-domain]  Cd Length: 459  Bit Score: 343.80  E-value: 8.54e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389   1 ITTILDPLTKHMAYPFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSM 80
Cdd:MTH00110 246 ITIILNPLTEFMAYPFLMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSFMGATALMIAHGLTSSM 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  81 LFCLANSNYERIHSRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITAL 160
Cdd:MTH00110 326 LFCLANSNYERIHSRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMSSFSWSNITIILMGLNMLITAL 405

                        170       180
                 ....*....|....*....|....*.
gi 168812389 161 YSLYMLTITQRGKLTYHTYNLNPSLT 186
Cdd:MTH00110 406 YSLYMLITTQRGKLTHHINNIKPSFT 431
 
Name Accession Description Interval E-value
ND4 MTH00110
NADH dehydrogenase subunit 4; Provisional
 1-186 8.54e-119

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177172 [Multi-domain]  Cd Length: 459  Bit Score: 343.80  E-value: 8.54e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389   1 ITTILDPLTKHMAYPFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSM 80
Cdd:MTH00110 246 ITIILNPLTEFMAYPFLMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSFMGATALMIAHGLTSSM 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  81 LFCLANSNYERIHSRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITAL 160
Cdd:MTH00110 326 LFCLANSNYERIHSRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMSSFSWSNITIILMGLNMLITAL 405

                        170       180
                 ....*....|....*....|....*.
gi 168812389 161 YSLYMLTITQRGKLTYHTYNLNPSLT 186
Cdd:MTH00110 406 YSLYMLITTQRGKLTHHINNIKPSFT 431
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 9-166 2.33e-34

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 125.96  E-value: 2.33e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389   9 TKHMAYPFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSN 88
Cdd:COG1008  271 SAYFAPLLAALGVIGIIYGALVALAQTDLKRLIAYSSVSHMGFVLLGIFALNPLGLQGAVLQMVSHGLITAALFLLVGVL 350

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 168812389  89 YERIHSRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITALYSLYML 166
Cdd:COG1008  351 YDRTHTRDIADLGGLAKRMPVLAALFLLAALASLGLPGTSGFVGEFLVLLGAFQVNPWLAILAALGLILTAAYLLWMY 428
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 9-175 3.96e-30

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 114.65  E-value: 3.96e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389    9 TKHMAYPFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSN 88
Cdd:TIGR01972 265 SLYFAPVLAALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVLLGIFSFNELGISGAVFQMISHGLITAALFLLVGVL 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389   89 YERIHSRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITALYSLYMLTI 168
Cdd:TIGR01972 345 YERAHTRDIAKYGGLANKMPVLAAFFMLFAMASLGLPGTSGFVGEFLILLGSFKVNPVVAFLAALGIVLAAAYMLTLYKR 424


                  ....*..
gi 168812389  169 TQRGKLT 175
Cdd:TIGR01972 425 VFFGELS 431
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 12-153 4.47e-29

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 108.94  E-value: 4.47e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389   12 MAYPFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANS-NYE 90
Cdd:pfam00361 146 IQQILLILAIISMLLGSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLTHGLFSAGLFLCAGSvIYR 225

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 168812389   91 RIHSRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGL 153
Cdd:pfam00361 226 RVHTRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGV 288
 
Name Accession Description Interval E-value
ND4 MTH00110
NADH dehydrogenase subunit 4; Provisional
 1-186 8.54e-119

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177172 [Multi-domain]  Cd Length: 459  Bit Score: 343.80  E-value: 8.54e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389   1 ITTILDPLTKHMAYPFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSM 80
Cdd:MTH00110 246 ITIILNPLTEFMAYPFLMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSFMGATALMIAHGLTSSM 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  81 LFCLANSNYERIHSRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITAL 160
Cdd:MTH00110 326 LFCLANSNYERIHSRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMSSFSWSNITIILMGLNMLITAL 405

                        170       180
                 ....*....|....*....|....*.
gi 168812389 161 YSLYMLTITQRGKLTYHTYNLNPSLT 186
Cdd:MTH00110 406 YSLYMLITTQRGKLTHHINNIKPSFT 431
ND4 MTH00124
NADH dehydrogenase subunit 4; Provisional
 1-186 9.56e-92

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214427 [Multi-domain]  Cd Length: 457  Bit Score: 274.77  E-value: 9.56e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389   1 ITTILDPLTKHMAYPFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSM 80
Cdd:MTH00124 246 ITLLLPPLSNTLHYPFLTLALWGALMTSLICLRQTDLKSLIAYSSVSHMGLVIAATMIQTPWSLSGAMILMIAHGLTSSM 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  81 LFCLANSNYERIHSRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITAL 160
Cdd:MTH00124 326 LFCLANTNYERTHSRTLLLTRGLQLLLPLMTTWWLLANLTNMALPPTINLMGELTIMTSLFNWSPTTIILTGLATLITAS 405

                        170       180
                 ....*....|....*....|....*.
gi 168812389 161 YSLYMLTITQRGKLTYHTYNLNPSLT 186
Cdd:MTH00124 406 YTLYMFLSTQRGTLPTHITTIQPTHT 431
ND4 MTH00068
NADH dehydrogenase subunit 4; Provisional
 1-186 1.24e-84

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214417 [Multi-domain]  Cd Length: 458  Bit Score: 256.77  E-value: 1.24e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389   1 ITTILDPLTKHMAYPFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSM 80
Cdd:MTH00068 246 ISILLTPLSKELSYPFIILALWGVLMTSLICLRQTDLKSLIAYSSVSHMGLVIAAALIQTPWSFSGAIILMISHGLTSSA 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  81 LFCLANSNYERIHSRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITAL 160
Cdd:MTH00068 326 LFCLANTNYERTHSRTLLLLRGAQTILPLMATWWLLSNLSNMALPPSPNLWGELTIMVSLFNWSNWTILITGLGTLITAA 405

                        170       180
                 ....*....|....*....|....*.
gi 168812389 161 YSLYMLTITQRGKLTYHTYNLNPSLT 186
Cdd:MTH00068 406 YTLYMFLMTQRGPLPNHLKTLFPTYT 431
ND4 MTH00127
NADH dehydrogenase subunit 4; Provisional
 1-186 2.07e-74

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177186 [Multi-domain]  Cd Length: 459  Bit Score: 230.61  E-value: 2.07e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389   1 ITTILDPLTKHMAYPFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSM 80
Cdd:MTH00127 247 MMVMLDPLTKELSYPFIILALWGIIMTGSICLRQTDLKSLIAYSSVSHMGLVAGGILIQTPWGFTGALILMIAHGLTSSA 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  81 LFCLANSNYERIHSRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITAL 160
Cdd:MTH00127 327 LFCLANTNYERTHSRTMLLARGLQMILPLMATWWFIASLANLALPPLPNLMGELMIITSLFNWSPWTLALTGLGTLITAG 406

                        170       180
                 ....*....|....*....|....*.
gi 168812389 161 YSLYMLTITQRGKLTYHTYNLNPSLT 186
Cdd:MTH00127 407 YSLYMFLMTQRGPLPDHIIALNPSHT 432
ND4 MTH00206
NADH dehydrogenase subunit 4; Provisional
 1-186 1.18e-71

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214458 [Multi-domain]  Cd Length: 450  Bit Score: 223.28  E-value: 1.18e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389   1 ITTILDPLTKHMAYPFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSM 80
Cdd:MTH00206 242 IILILGPSTKLSSYFFIILGLWGSIMTSSICLRQTDLKSLIAYSSVSHMSLVTAGILSGSPWGFKGALLLMIAHGLVSSA 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  81 LFCLANSNYERIHSRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITAL 160
Cdd:MTH00206 322 LFCLANLLYERSHTRTILGNRGLQMILPLLSFWWLLFFLANLGLPPFPNLFGELLIITSLFSWSNFTLPLLGLGFLFTAI 401

                        170       180
                 ....*....|....*....|....*.
gi 168812389 161 YSLYMLTITQRGKLTYHTYNLNPSLT 186
Cdd:MTH00206 402 YSLYMFVMTQHGKTPNHLLSLSPSST 427
ND4 MTH00044
NADH dehydrogenase subunit 4; Validated
 7-184 1.02e-51

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214411 [Multi-domain]  Cd Length: 458  Bit Score: 171.70  E-value: 1.02e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389   7 PLTKHMAYPFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLAN 86
Cdd:MTH00044 254 PSANNISFILIVFCCWGALITSIICLRQTDLKALIAYSSVGHMSLVAAGIFSGTNWGINGALILMIAHGLVSSALFCLAN 333

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  87 SNYERIHSRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITALYSLYML 166
Cdd:MTH00044 334 ILYERSGTRTLSITRGFKLITPLLPLWWLIFCAANLGLPPLPNLIGELLIISSIISWSILSFPIIGLATVFGAIYSLLIY 413

                        170
                 ....*....|....*...
gi 168812389 167 TITQRGKLTYHTYNLNPS 184
Cdd:MTH00044 414 QLTNSGSFPSWISNVSPI 431
ND4 MTH00163
NADH dehydrogenase subunit 4; Provisional
 14-184 4.93e-50

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214443 [Multi-domain]  Cd Length: 445  Bit Score: 166.87  E-value: 4.93e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  14 YPFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIH 93
Cdd:MTH00163 247 YIWISISLVGGVIVSLICLRQVDLKSLIAYSSVAHMGLVLGGLMTFSYWGLMGSLLMMIGHGLCSSGLFCLANIIYERLG 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  94 SRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITALYSLYMLTITQRGK 173
Cdd:MTH00163 327 SRSLLINKGLLNFMPSMSLWWFLLSSSNMAAPPSLNLLGEISLINSLISWSKLSMIFLMLLSFFSAAYSLYLYSYSQHGK 406

                        170
                 ....*....|.
gi 168812389 174 LTYHTYNLNPS 184
Cdd:MTH00163 407 YYSGLYSCSSG 417
ND4 MTH00150
NADH dehydrogenase subunit 4; Provisional
 16-173 2.57e-47

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214435 [Multi-domain]  Cd Length: 417  Bit Score: 159.23  E-value: 2.57e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  16 FLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIHSR 95
Cdd:MTH00150 220 LISLSLWGGVLTSLICLRQSDVKSLIAYSSVGHMSLVLAGVLSNTSWGWVGALIMMVSHGFCSSGLFCLANYTYEKVHSR 299

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 168812389  96 TMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITALYSLYMLTITQRGK 173
Cdd:MTH00150 300 SLFLSKGMLMLYPSLSLWWFLFCIINMAAPPSLNLLSEIMIFPSLISYSPWFFVPLGLMVFLSGLYSLYLYTSIQHGG 377
ND4 MTH00205
NADH dehydrogenase subunit 4; Provisional
 16-175 4.32e-44

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214457 [Multi-domain]  Cd Length: 448  Bit Score: 151.67  E-value: 4.32e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  16 FLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIHSR 95
Cdd:MTH00205 253 FFSISLWGGVMTGMICLRQVDLKSLIAYSSVGHMGLMVVGVFSNTSWGMNGAIIMMVAHGLCSSGMFALANVNYERTNSR 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  96 TMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITALYSLYMLTITQRGKLT 175
Cdd:MTH00205 333 SMLMNKGVLNTFPFLVLMWFLLISCNMAAPPSLNLASEILLIMSLLSSSKISGIPLSLISFLSGAYSLYLYSQSQHGKVS 412
ND4 MTH00014
NADH dehydrogenase subunit 4; Validated
 8-182 1.89e-40

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214399 [Multi-domain]  Cd Length: 452  Bit Score: 142.19  E-value: 1.89e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389   8 LTKHMAYPFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANS 87
Cdd:MTH00014 247 INKSLSAPFSSISLVGAVITSLICIRQPDLKSLIAYSSVGHMGLMTAGIMSNTSWGWQGALAMMIAHGLCSSALFALANM 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  88 NYERIHSRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITALYSLYMLT 167
Cdd:MTH00014 327 TYETTHTRSLFLTKGLLSLFPTMTMWWFLLSAANMAAPPSINLLSEIMLLTSILSSSLSTAILLAITSFLAAAYSLFLYT 406

                        170
                 ....*....|....*
gi 168812389 168 ITQRGKLTYHTYNLN 182
Cdd:MTH00014 407 STQHGSPPSFMNPLN 421
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 9-166 2.33e-34

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 125.96  E-value: 2.33e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389   9 TKHMAYPFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSN 88
Cdd:COG1008  271 SAYFAPLLAALGVIGIIYGALVALAQTDLKRLIAYSSVSHMGFVLLGIFALNPLGLQGAVLQMVSHGLITAALFLLVGVL 350

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 168812389  89 YERIHSRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITALYSLYML 166
Cdd:COG1008  351 YDRTHTRDIADLGGLAKRMPVLAALFLLAALASLGLPGTSGFVGEFLVLLGAFQVNPWLAILAALGLILTAAYLLWMY 428
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 9-175 3.96e-30

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 114.65  E-value: 3.96e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389    9 TKHMAYPFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSN 88
Cdd:TIGR01972 265 SLYFAPVLAALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVLLGIFSFNELGISGAVFQMISHGLITAALFLLVGVL 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389   89 YERIHSRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITALYSLYMLTI 168
Cdd:TIGR01972 345 YERAHTRDIAKYGGLANKMPVLAAFFMLFAMASLGLPGTSGFVGEFLILLGSFKVNPVVAFLAALGIVLAAAYMLTLYKR 424


                  ....*..
gi 168812389  169 TQRGKLT 175
Cdd:TIGR01972 425 VFFGELS 431
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
 15-165 2.89e-29

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 112.07  E-value: 2.89e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  15 PFLM-LCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIH 93
Cdd:MTH00217 273 PLIQtLSLLAIIYGSLTTCRQVDLKRIIAYSSVAHMGLVTLGIFSHTIQGLVAAIFLMLAHGLVSSALFIAVTFLYERHH 352

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 168812389  94 SRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITALYSLYM 165
Cdd:MTH00217 353 TRLIKYYRGMVITMPLFGILMLLLVLANASIPLSCNFVGEFLSLLAAFEYSYIVGVLASLGMVLSAGYSIYL 424
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 12-153 4.47e-29

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 108.94  E-value: 4.47e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389   12 MAYPFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANS-NYE 90
Cdd:pfam00361 146 IQQILLILAIISMLLGSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLTHGLFSAGLFLCAGSvIYR 225

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 168812389   91 RIHSRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGL 153
Cdd:pfam00361 226 RVHTRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGV 288
ND4 MTH00204
NADH dehydrogenase subunit 4; Provisional
 17-165 2.47e-28

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 164750 [Multi-domain]  Cd Length: 485  Bit Score: 109.77  E-value: 2.47e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  17 LMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIHSRT 96
Cdd:MTH00204 279 VMLSVIAVIYGSLTTCRQVDFKRLIAYSSVAHMGLVPLGLFTHTIEGLVAAVFLMLAHGFVSSALFIAVTFLYERHHTRL 358

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 168812389  97 MLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITALYSLYM 165
Cdd:MTH00204 359 IKYYRGLTLTMPLFVIIMLVLSLANMGFPLSCNFVGEFFSLLAAFEYSLGLGVLVTSGMVWSAAYSLYL 427
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 7-165 3.73e-28

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 109.14  E-value: 3.73e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389   7 PLTKHMAYPFLM-LCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLA 85
Cdd:PRK05846 270 PDASHEFAPIIItLGVIAIIYGALVALAQTDIKKLIAYSSISHMGFVTLGIFAGNQLGIQGAIFQMISHGLSSAALFLLV 349

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  86 NSNYERIHSRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITALYSLYM 165
Cdd:PRK05846 350 GVLYDRLHTRDIADYGGLAKVMPVLAAFFLFFAMASLGLPGTSGFVGEFLILLGSFQVNPVIAFIATTGLILAAVYSLWL 429
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
 10-164 2.86e-23

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 95.76  E-value: 2.86e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  10 KHMAYPFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNY 89
Cdd:MTH00226 293 QNLAPAVIAMGIVGIVYGSFATCRQIDVKRLVAYSSVAHMGLVSITLVTHDIIGLTGSIFIMLAHGIVSSLLFILVTILY 372

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 168812389  90 ERIHSRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITALYSLY 164
Cdd:MTH00226 373 DRHHTRLIKYYRGLSITMPIWGTIMIVTSLANVAVPPSGNFIGEYLSILSSFNWNPIIGVFVCSGVILSAVYSFY 447
ND4 MTH00094
NADH dehydrogenase subunit 4; Provisional
 16-182 3.02e-18

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177157 [Multi-domain]  Cd Length: 403  Bit Score: 81.11  E-value: 3.02e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  16 FLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIHSR 95
Cdd:MTH00094 216 WIIFSLLGMILSSFCCVFQSDSKSLAAYSSVTHMSFLLLSLVYMSMSGKLSGLMMMLAHGYTSTLMFYLIGEFYHISKSR 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  96 TMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITALYSLYMLTITQRGKLT 175
Cdd:MTH00094 296 LIYFMNSFFSSSMFFGLIFSLVFLSNSGVPPSLSFFSEFLIISNSFMKNKFSFFFIFFYFLVSFYYSLFLIVSSFMGKKF 375


                 ....*..
gi 168812389 176 YHTYNLN 182
Cdd:MTH00094 376 SNFNNFN 382
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 34-166 4.67e-17

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 77.76  E-value: 4.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  34 QTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIHSRTMLLARGIQALLPLMATW 113
Cdd:PRK12561 272 QDNVKRRLAYSSVSHMGFVLLGIAAFTDLGISGAMLQMISHGLIAAALFFLTGVTYERTHTLSIPNMGGLAKVMPKTFAL 351

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389 114 WLLASLTNLALPPSINLIGEL--FVTMA-----SFSWSNITIILVGLNMLITALYSLYML 166
Cdd:PRK12561 352 FTASSMASLALPGMSGFVSELtvFLGITssdvySSTFRTITILLAAVGLILTPIYLLSML 411
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 24-170 2.74e-16

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 75.57  E-value: 2.74e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  24 MIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIHSRTMLLARGI 103
Cdd:COG0651  283 MLVGALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAGALFHLLNHALAKALLFLAAGAIERATGTRDLDKLGGL 362

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 168812389 104 QALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSN-ITIILVGLNMLITALYSLYMLTITQ 170
Cdd:COG0651  363 GKRMPLTAAAFLIGALALAGLPPLSGFVSKWLLLQAALEAGAwLLAAVLLLSSLLTLAYFVRIFGRAQ 430
ndhD CHL00011
NADH dehydrogenase subunit 4
 24-166 4.72e-15

NADH dehydrogenase subunit 4


Pssm-ID: 176954 [Multi-domain]  Cd Length: 498  Bit Score: 72.29  E-value: 4.72e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  24 MIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIhsRTMLLAR-- 101
Cdd:CHL00011 288 IIYAASTSLGQRNLKKRIAYSSVSHMGFIIIGIGSITDTGLNGAILQIISHGFIGAALFFLAGTSYDRI--RLVYLDEmg 365

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 168812389 102 GIQALLPLMATWWLLASLTNLALPPSINLIGEL-----FVTMASFSWSNITIILV--GLNMLITALYSLYML 166
Cdd:CHL00011 366 GIAIPMPKIFTMFSSFSMASLALPGMSGFVAELivffgIITSQKYLLMPKILITFvmAIGMILTPIYLLSML 437
PRK06473 PRK06473
NADH-quinone oxidoreductase subunit M;
28-185 1.10e-14

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 235810 [Multi-domain]  Cd Length: 500  Bit Score: 70.88  E-value: 1.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  28 SSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIHSRTMLLARGI---Q 104
Cdd:PRK06473 286 ASCAIAQKDMKKMVAYSSIGHMGYILLAAAAATPLSILAAVFQMISHGLISALLFLLVGVVYKKTGSRDVDVLRGLlnpE 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389 105 ALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITALYSLYMLTITQRGKLTYHTYNLNPS 184
Cdd:PRK06473 366 RGLPITGSLMILGVMASAGIPGMVGFIAEFLVFRGSFPIFPVQTLLCMIGTGLTAVYFLLLVNRVFFGRLTAELSNLPRV 445


                 .
gi 168812389 185 L 185
Cdd:PRK06473 446 L 446
PRK02546 PRK02546
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 34-166 1.97e-14

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 235050 [Multi-domain]  Cd Length: 525  Bit Score: 70.51  E-value: 1.97e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  34 QTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIHSRTMLLARGIQALLPLMATW 113
Cdd:PRK02546 300 QRNLKRKIAYSSISHMGFVLIGIGSFTDLGTSGAMLQMISHGLIGASLFFLVGATYDRTHTLMLDEMGGVGQKMRKMFAM 379

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389 114 WLLASLTNLALPPSINLIGEL--FVTMA-----SFSWSNITIILVGLNMLITALYSLYML 166
Cdd:PRK02546 380 WTACSLASLALPGMSGFVAELmvFVGFAtsdayTLPFRVVVVFLAAVGVILTPIYLLSML 439
PRK06458 PRK06458
hydrogenase 4 subunit F; Validated
 32-160 4.74e-13

hydrogenase 4 subunit F; Validated


Pssm-ID: 235805 [Multi-domain]  Cd Length: 490  Bit Score: 66.49  E-value: 4.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  32 LRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIHSRTMLLARGIQALLPLMA 111
Cdd:PRK06458 300 LRQRDIKRLFAYSSIEHMGLIAFALGIGGPLGIFAALLHMLNHSLTKSAIFFASGNVLQKYGTRDINVIRGLLKVSPLTG 379

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 168812389 112 TWWLLASLTNLALPPSINLIGELFV---TMASFSWSNITIILVGLNMLITAL 160
Cdd:PRK06458 380 WGLMLGALAIAGMPPFGVFISEFLIltaGLARGPLLIAILLLLLLTLAFAAL 431
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 15-161 6.16e-13

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 66.06  E-value: 6.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  15 PFLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIHS 94
Cdd:PRK08375 273 LLAVLALLSMLVGSLAALGQDDVKRVLAYSTVSQMGYILLGLALLTPLALAAGLLHLLHHALMKGALFLAAGAIEVTYGT 352

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 168812389  95 RTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFS-WSNITIILVGLNMLITALY 161
Cdd:PRK08375 353 RRLSELSGLGRRMPLTAAAFAVASLSLIGVPPTSGFVSKWYLVVGAVEaGQWLVLAVLLASSLLALLY 420
PRK07363 PRK07363
NADH-quinone oxidoreductase subunit M;
19-178 3.62e-10

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 180945 [Multi-domain]  Cd Length: 501  Bit Score: 57.80  E-value: 3.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  19 LCLWGMIMT---SSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIHSR 95
Cdd:PRK07363 274 LAIIGTISViygALSAIAQKDIKRMVAYSSIGHMGYILVAAAAGTQLSLLGAVAQMISHGLILALLFHLVGIVERKVGTR 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  96 TMLLARGIQAL---LPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITALYSLYMLTITQRG 172
Cdd:PRK07363 354 DLDVLNGLMNPirgLPLTSALLVLAGMASAGIPGLVGFVAEFIVFQGSFSTFPIPTLLCIVASGLTAVYFVILLNRTCFG 433


                 ....*.
gi 168812389 173 KLTYHT 178
Cdd:PRK07363 434 RLDNKL 439
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 34-166 1.91e-09

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 55.75  E-value: 1.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  34 QTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIHSRTMLLARGIQALLPLMATW 113
Cdd:PRK12667 316 QKDVKRLLAYSTISHMGYIFMGIGIGTQLGLAAALFHIINHAIAKSLLFLASGVFIHAAGTRDIDELAGLGRKMPIASFA 395

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 168812389 114 WLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLnmLITALYSLYML 166
Cdd:PRK12667 396 FLIGALSLVGIPPLNGFFSKLLLFNALLESGFYLPALVLL--IASAISLVGYF 446
PRK12647 PRK12647
putative monovalent cation/H+ antiporter subunit A; Reviewed
 24-160 8.42e-09

putative monovalent cation/H+ antiporter subunit A; Reviewed


Pssm-ID: 237156 [Multi-domain]  Cd Length: 761  Bit Score: 54.15  E-value: 8.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  24 MIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIHSRTMLLARGI 103
Cdd:PRK12647 270 MLTGALLAVRQTDLKLILAYSTVSALGTLVMLLGLGSELAIKAAVLFLVAHSLYKGALFMVAGIIDHETGTRDITKLGGL 349

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 168812389 104 QALLPLMATWWLLASLTNLALPPSINLIGELFVTMASF---SWSNI-TIILVGLNMLITAL 160
Cdd:PRK12647 350 RRAMPITAAAALLAALSMAGLPPLFGFLAKELIYEALLeapLWSLIlTVAAVLGNALMVAV 410
PRK06589 PRK06589
putative monovalent cation/H+ antiporter subunit D; Reviewed
 24-168 1.33e-07

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 235835 [Multi-domain]  Cd Length: 489  Bit Score: 50.59  E-value: 1.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  24 MIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIHSRTMLLARGI 103
Cdd:PRK06589 291 IFYSSLKALKTDNIKKILAYSTISQLSLALLSAFILTPKALGAAILHLVSHSFAKICLFYSMGSIYSLKKEDQVDKLHGT 370

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 168812389 104 QALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITI-ILVGLNMLITA-LYSLYMLTI 168
Cdd:PRK06589 371 SKSFPLISFIISISSLSLIGIPIFSGFISKFLILLAASEQNQPWLsIIVMLVVIASSiLSALYLLKI 437
PRK12650 PRK12650
DUF4040 family protein;
25-85 8.53e-07

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 48.12  E-value: 8.53e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 168812389  25 IMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLA 85
Cdd:PRK12650 284 LMGAVFAVQKTDLKKLTAYSTVSQLGWIVATIGVGTPFALTAAVVHTLAHALFKSSLFMLI 344
NuoL COG1009
Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ ...
 24-173 3.92e-06

Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion]; Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440633 [Multi-domain]  Cd Length: 608  Bit Score: 46.30  E-value: 3.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  24 MIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQtpwSFMGATILMVAHGLTSSMLFCLANSNYERIHSRTMLLARGI 103
Cdd:COG1009  286 ALFAALIALAQTDIKRVLAYSTVSQLGYMFLALGVG---AYVAALFHLLTHAFFKALLFLGAGSVIHATGTRDIRKMGGL 362

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 168812389 104 QALLPLMATWWLLASLTNLALPP-----SINLIGELFVTMASFSWSNITIILVGlnMLITALYSLYMLTITQRGK 173
Cdd:COG1009  363 RKKMPITAITFLIGALSLAGIPPfagffSKEAILEAALEAGGLGPLLLAVALLG--AFLTAFYSFRLFFLVFFGK 435
PRK08377 PRK08377
NADH dehydrogenase subunit N; Validated
 30-149 1.45e-05

NADH dehydrogenase subunit N; Validated


Pssm-ID: 181406 [Multi-domain]  Cd Length: 494  Bit Score: 44.37  E-value: 1.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  30 ICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIHSRTMLLARGIQALLPL 109
Cdd:PRK08377 290 SALRQKNVKRMIAYSSIGQVGMIALALALGTQAGVDAGVFHMINHAIVKALLFLAVGYVGITLGGTEIEKFEGLGKRMPL 369

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 168812389 110 MATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITII 149
Cdd:PRK08377 370 TALALTIGALSTVGIPLFNVFWSKFRIILAGLSAGYTWPV 409
PRK08676 PRK08676
hydrogenase membrane subunit; Validated
 32-159 1.59e-05

hydrogenase membrane subunit; Validated


Pssm-ID: 181537 [Multi-domain]  Cd Length: 485  Bit Score: 44.36  E-value: 1.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  32 LRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIHSRTMLLARGIQALLPLMA 111
Cdd:PRK08676 292 LSQRNLKKLIAFSSIEHMGLMLLGIGIGTPLALFWMLFHMLAHSLVKSGLFFSAGILHRQYRSDRFDRIFDVFRLQPVAA 371

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 168812389 112 TWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNMLITA 159
Cdd:PRK08676 372 WGVILGSAAIIGMPPFPLFLSKFFILLQLGGISVWLVLAVLLLLLLAA 419
PRK06525 PRK06525
hydrogenase 4 subunit D; Validated
 12-156 3.46e-05

hydrogenase 4 subunit D; Validated


Pssm-ID: 180606 [Multi-domain]  Cd Length: 479  Bit Score: 43.42  E-value: 3.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  12 MAYPFLMLclwgmimtssicLRQTDLKSLIAYSSVSHMALVVVGILIQ---TPWSFMGATILMVAHGLTSSMLFCLANSN 88
Cdd:PRK06525 283 LLYGFLMY------------LPQQDMKRLLAYSTITQLGYMFFGLSLAilgSRLALEGSIAYIFNHAFAKSLFFLVAGAL 350

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 168812389  89 YERIHSRTMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASFSWSNITIILVGLNML 156
Cdd:PRK06525 351 SYSCGTRLLPRLRGVLKKLPLVGVGFCVAALAITGVPPFNGFFSKFPIFAAGFELSVEYWILLPAMVL 418
PRK12662 PRK12662
putative monovalent cation/H+ antiporter subunit D; Reviewed
 16-152 4.89e-05

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 183662 [Multi-domain]  Cd Length: 492  Bit Score: 42.80  E-value: 4.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  16 FLMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIHSR 95
Cdd:PRK12662 282 FMILAALAIVFGSVLAILSKDIKRIFAYSSISHIGYIILAVSLNTYYGLAAAVAYIVNHSIVKSALFMVSGSISYHFGTT 361

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  96 TMLLARGIQALLPLMATWWLLASLTNLALPPSINLIGELFV---TMASFSWSNITIILVG 152
Cdd:PRK12662 362 KLEDCLNLWKSMPKITLAFVLLSLSLIGMPPTSGFVAKWYIldaFIKSNAWIGLVVLLVG 421
PRK08667 PRK08667
hydrogenase membrane subunit; Validated
 32-141 5.87e-05

hydrogenase membrane subunit; Validated


Pssm-ID: 236331 [Multi-domain]  Cd Length: 644  Bit Score: 42.80  E-value: 5.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  32 LRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMG----ATILMVA-------HGLTSSMLFCLANSNYERIHSRTMLLA 100
Cdd:PRK08667 289 LKEHDLKGLLAYSSIENIGIILMGIGLYVIFGVYGldtlALLALGGalfhslnHALFKSLLFLTAGSVVHATGTRNIEKM 368

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 168812389 101 RGIQALLPLMATWWLLASLTNLALPPSINLIGELFVTMASF 141
Cdd:PRK08667 369 GGLVKLMPYTSALFLVGAVSIAALPPFNGFASELLLYESFF 409
PRK06277 PRK06277
energy conserving hydrogenase EhbF;
17-126 9.37e-05

energy conserving hydrogenase EhbF;


Pssm-ID: 235767 [Multi-domain]  Cd Length: 478  Bit Score: 41.94  E-value: 9.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168812389  17 LMLCLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLFCLANSNYERIHSRT 96
Cdd:PRK06277 270 IALSVLAMVFGVVMALLQTDYKRLLAYHAISQGGYVAAGLALGTPLGIVAGIFHAINHVIYKSALFLGAGIVSYRTKTSN 349

                         90       100       110
                 ....*....|....*....|....*....|
gi 168812389  97 MLLARGIQALLPLMATWWLLASLTNLALPP 126
Cdd:PRK06277 350 LRKLGGLLPVMPVVAFMVLCAKLAISGVPP 379
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 32-78 2.43e-04

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 40.87  E-value: 2.43e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 168812389  32 LRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTS 78
Cdd:COG1007  288 LAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGVSAALFYLLAYLFMN 334
PRK08668 PRK08668
NADH dehydrogenase subunit M; Validated
 33-82 2.78e-04

NADH dehydrogenase subunit M; Validated


Pssm-ID: 236332 [Multi-domain]  Cd Length: 610  Bit Score: 40.75  E-value: 2.78e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 168812389  33 RQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLF 82
Cdd:PRK08668 292 LQEDIKKLIAYSSVANGGYILVGLGLGTSLGFAGGLFHVFNHALFKGLFF 341
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
32-78 9.39e-04

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 39.03  E-value: 9.39e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 168812389  32 LRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTS 78
Cdd:PRK05777 289 LSQTNIKRLLAYSSIAHAGYLLVGLAAGTAEGYSAVLFYLLAYLFMT 335
PRK12644 PRK12644
putative monovalent cation/H+ antiporter subunit A; Reviewed
 24-82 4.58e-03

putative monovalent cation/H+ antiporter subunit A; Reviewed


Pssm-ID: 237154 [Multi-domain]  Cd Length: 965  Bit Score: 37.21  E-value: 4.58e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 168812389  24 MIMTSSICLRQTDLKSLIAYSSVSHMALVVVGILIQTPWSFMGATILMVAHGLTSSMLF 82
Cdd:PRK12644 278 MLLGGWRALRQHDLKLILAYGTVSQLGFLTVLVGIGTRDAALAGLAMLLAHALFKAALF 336
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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