NCBI Conserved Domain Search

Conserved domains on [gi|168229222|ref|NP_666513|]

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olfactory receptor 1305 [Mus musculus]

Protein Classification

olfactory receptor family 4 protein( domain architecture ID 11607035)

olfactory receptor family 4 protein is an odorant receptor belonging to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

26-291

2.06e-159

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 445.11 E-value: 2.06e-159

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  26 FIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSH 105
Cdd:cd15226    2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 106 AVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLV 185
Cdd:cd15226   82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 186 KLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSPST 265
Cdd:cd15226  162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241

                        250       260
                 ....*....|....*....|....*.
gi 168229222 266 HVDKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15226  242 PVDKFLAVFYTVITPLLNPIIYTLRN 267

Name

Accession

Description

Interval

E-value

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

26-291

2.06e-159

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 445.11 E-value: 2.06e-159

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  26 FIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSH 105
Cdd:cd15226    2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 106 AVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLV 185
Cdd:cd15226   82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 186 KLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSPST 265
Cdd:cd15226  162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241

                        250       260
                 ....*....|....*....|....*.
gi 168229222 266 HVDKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15226  242 PVDKFLAVFYTVITPLLNPIIYTLRN 267

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

32-303

2.02e-33

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 123.77 E-value: 2.02e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222   32 CLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTE 111
Cdd:pfam13853   2 CLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIME 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  112 MVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLVKLACTD 191
Cdd:pfam13853  82 SAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCAD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  192 -----TYKLeLMITANSGFISLiaffLLIISYVFLLTTVQKQSSGCSS-KALSTLLAHITVVVLFFGPLIFFYVCPSPST 265
Cdd:pfam13853 162 ikvnnIYGL-FVVTSTFGIDSL----LIVLSYGLILRTVLGIASREGRlKALNTCGSHVCAVLAFYTPMIGLSMVHRFGH 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 168229222  266 HVDKFLAIFDA----VLTPFLNPIIYTLRNRDMKIAIRKVFC 303
Cdd:pfam13853 237 NVPPLLQIMMAnaylFFPPVLNPIVYSVKTKQIRDCVKRMLL 278

PHA03087

G protein-coupled chemokine receptor-like protein; Provisional

27-253

1.01e-05

G protein-coupled chemokine receptor-like protein; Provisional

Pssm-ID: 222976 [Multi-domain] Cd Length: 335 Bit Score: 46.31 E-value: 1.01e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  27 IFFFTCLFYVSSLTGNfIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAaPKMICDLFRKQkvISFGGCISQI--FFS 104
Cdd:PHA03087  43 LIVVYSTIFFFGLVGN-IIVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTL-PFQIYYYILFQ--WSFGEFACKIvsGLY 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDiprl 184
Cdd:PHA03087 119 YIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNN---- 194

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 168229222 185 vklactDTYKLELMITANSGFIS-LIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGP 253
Cdd:PHA03087 195 ------KTMNWKLFINFEINIIGmLIPLTILLYCYSKILITLKGiNKSKKNKKAIKLVLIIVILFVIFWLP 259

Name

Accession

Description

Interval

E-value

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

26-291

2.06e-159

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 445.11 E-value: 2.06e-159

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  26 FIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSH 105
Cdd:cd15226    2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 106 AVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLV 185
Cdd:cd15226   82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 186 KLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSPST 265
Cdd:cd15226  162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241

                        250       260
                 ....*....|....*....|....*.
gi 168229222 266 HVDKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15226  242 PVDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

25-291

5.97e-112

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 324.94 E-value: 5.97e-112

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFtcLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15939    3 CFVVFL--LIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15939   81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSPS 264
Cdd:cd15939  161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                        250       260
                 ....*....|....*....|....*..
gi 168229222 265 THVDKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15939  241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

26-291

5.23e-107

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 312.35 E-value: 5.23e-107

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  26 FIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSH 105
Cdd:cd15936    2 FLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 106 AVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLV 185
Cdd:cd15936   82 FTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 186 KLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSPST 265
Cdd:cd15936  162 KLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTF 241

                        250       260
                 ....*....|....*....|....*.
gi 168229222 266 HVDKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15936  242 PMDKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

25-291

5.55e-104

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 304.79 E-value: 5.55e-104

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd13954    1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd13954   81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSP 263
Cdd:cd13954  161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKiPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 168229222 264 --STHVDKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd13954  241 sySSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

25-291

1.67e-95

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 283.18 E-value: 1.67e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15940    1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15940   81 HLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSPS 264
Cdd:cd15940  161 IKLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTS 240

                        250       260
                 ....*....|....*....|....*..
gi 168229222 265 THVDKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15940  241 FSEDKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

25-298

1.92e-95

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 283.58 E-value: 1.92e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15225    1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15225   81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSP 263
Cdd:cd15225  161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKiPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 168229222 264 --STHVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15225  241 sySPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

26-291

1.98e-94

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 280.50 E-value: 1.98e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  26 FIFFFTCLFYVSSLTGNFIIVVTVTSDPYL-HSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15935    2 LLFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15935   82 HFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSPS 264
Cdd:cd15935  162 IKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSS 241

                        250       260
                 ....*....|....*....|....*..
gi 168229222 265 THVDKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15935  242 SSVDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

26-291

7.63e-94

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 278.93 E-value: 7.63e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  26 FIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSH 105
Cdd:cd15937    2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 106 AVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLV 185
Cdd:cd15937   82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 186 KLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSPST 265
Cdd:cd15937  162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSF 241

                        250       260
                 ....*....|....*....|....*.
gi 168229222 266 HVDKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15937  242 PMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

26-291

4.35e-91

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 272.07 E-value: 4.35e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  26 FIFFFtcLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSH 105
Cdd:cd15230    4 FVLFL--LIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 106 AVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLV 185
Cdd:cd15230   82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 186 KLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSPS 264
Cdd:cd15230  162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRiRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSS 241

                        250       260
                 ....*....|....*....|....*....
gi 168229222 265 THV--DKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15230  242 YSLdqDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

26-297

9.58e-89

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 266.34 E-value: 9.58e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  26 FIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSH 105
Cdd:cd15421    2 FLFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 106 AVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLV 185
Cdd:cd15421   82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 186 KLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTV-QKQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSP- 263
Cdd:cd15421  162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVlRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSy 241

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 168229222 264 -STHVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIA 297
Cdd:cd15421  242 hSPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGA 276

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

26-291

7.78e-87

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 261.47 E-value: 7.78e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  26 FIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSH 105
Cdd:cd15915    2 FLFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 106 AVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLV 185
Cdd:cd15915   82 FLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 186 KLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSS--KALSTLLAHITVVVLFFGPLIFFYVCPSP 263
Cdd:cd15915  162 KLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKVRSKEGrhKAFSTCASHLTVVLLLYGPALFTYIRPSS 241

                        250       260       270
                 ....*....|....*....|....*....|
gi 168229222 264 STHV--DKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15915  242 GDSLeqDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

26-291

1.20e-86

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 260.67 E-value: 1.20e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  26 FIFFFtcLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSH 105
Cdd:cd15237    4 FILFL--LIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 106 AVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLV 185
Cdd:cd15237   82 ALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 186 KLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCP--S 262
Cdd:cd15237  162 KLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRiQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPhsT 241

                        250       260
                 ....*....|....*....|....*....
gi 168229222 263 PSTHVDKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15237  242 HSPDQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

25-298

3.51e-86

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 259.89 E-value: 3.51e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15231    1 LLLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15231   81 VSFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSP 263
Cdd:cd15231  161 LKLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKiRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 168229222 264 --STHVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15231  241 gySLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

26-291

3.62e-86

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 259.69 E-value: 3.62e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  26 FIFFFtcLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSH 105
Cdd:cd15227    4 FVLFL--LIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 106 AVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLV 185
Cdd:cd15227   82 FFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 186 KLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSP- 263
Cdd:cd15227  162 KLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRiPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSd 241

                        250       260
                 ....*....|....*....|....*....
gi 168229222 264 -STHVDKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15227  242 sPSLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

25-291

4.12e-86

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 259.34 E-value: 4.12e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15912    1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15912   81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK--QSSGCsSKALSTLLAHITVVVLFFGPLIFFYVCPS 262
Cdd:cd15912  161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRipSASGR-QKAFSTCASHLTVVSIFYGSCIFMYVRPS 239

                        250       260       270
                 ....*....|....*....|....*....|.
gi 168229222 263 P--STHVDKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15912  240 QssSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

24-298

7.58e-86

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 259.08 E-value: 7.58e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  24 QVFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFF 103
Cdd:cd15235    1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 104 SHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPR 183
Cdd:cd15235   81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 184 LVKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPS 262
Cdd:cd15235  161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKvPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 168229222 263 PSTHVDK--FLAIFDAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15235  241 SSYSADKdrVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

27-298

8.52e-86

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 258.90 E-value: 8.52e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  27 IFFFTCL-FYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSH 105
Cdd:cd15228    2 ILFVLFLaFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 106 AVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLV 185
Cdd:cd15228   82 FLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 186 KLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSG-CSSKALSTLLAHITVVVLFFGPLIFFYVCPSPS 264
Cdd:cd15228  162 KLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAeGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPS 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 168229222 265 THVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15228  242 PVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

26-291

1.59e-85

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 257.88 E-value: 1.59e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  26 FIFFFtcLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSH 105
Cdd:cd15938    4 FALFL--LAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 106 AVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLV 185
Cdd:cd15938   82 FVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 186 KLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVqkQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSPST 265
Cdd:cd15938  162 KLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTI--RSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTF 239

                        250       260
                 ....*....|....*....|....*.
gi 168229222 266 HVDKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15938  240 PVDKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

27-291

5.04e-85

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 256.78 E-value: 5.04e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  27 IFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHA 106
Cdd:cd15947    3 LFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLW 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 107 VGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLVK 186
Cdd:cd15947   83 LGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 187 LACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCP--SP 263
Cdd:cd15947  163 LACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRiKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPpsSY 242

                        250       260
                 ....*....|....*....|....*...
gi 168229222 264 STHVDKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15947  243 SQDQGKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

11-302

9.77e-85

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 256.91 E-value: 9.77e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  11 EFVLLGLSNSWEIQVFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQK 90
Cdd:cd15943    1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  91 VISFGGCISQIFFSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCG 170
Cdd:cd15943   81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 171 PNILDSFYCDIPRLVKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVL 249
Cdd:cd15943  161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRiHSSEGRRKAFSTCASHLMAVTI 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 168229222 250 FFGPLIFFYVCPSPSTHV--DKFLAIFDAVLTPFLNPIIYTLRNRDMKIAIRKVF 302
Cdd:cd15943  241 FYGTTLFMYLRPSSSYSLdqDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

12-295

4.64e-84

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 254.94 E-value: 4.64e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  12 FVLLGLSNSWEIQVFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKV 91
Cdd:cd15408    1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  92 ISFGGCISQIFFSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGP 171
Cdd:cd15408   81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 172 NILDSFYCDIPRLVKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSS-KALSTLLAHITVVVLF 250
Cdd:cd15408  161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRhKAFSTCASHLTAVTLF 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 168229222 251 FGPLIFFYVCPSP--STHVDKFLAIFDAVLTPFLNPIIYTLRNRDMK 295
Cdd:cd15408  241 YGSLAFMYLRPSSrySLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

23-291

6.50e-83

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 251.25 E-value: 6.50e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  23 IQVFIFFFtcLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIF 102
Cdd:cd15911    1 ILLFLLFL--VIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 103 FSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIP 182
Cdd:cd15911   79 FFGSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 183 RLVKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCS-SKALSTLLAHITVVVLFFGPLIFFYVCP 261
Cdd:cd15911  159 PLLKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGrQKAFSTCSSHLIVVTIFYGTLIIVYVVP 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 168229222 262 SPSTHVD--KFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15911  239 STNTSRDlnKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

25-300

1.26e-82

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 251.02 E-value: 1.26e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15417    1 IILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15417   81 SGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSG-CSSKALSTLLAHITVVVLFFGPLIFFYVCPSP 263
Cdd:cd15417  161 LSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAkGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 168229222 264 --STHVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAIRK 300
Cdd:cd15417  241 shSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

25-298

1.76e-82

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 250.59 E-value: 1.76e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15229    1 IFLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15229   81 FFFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSP 263
Cdd:cd15229  161 LPLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRiRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 168229222 264 STHV--DKFLAIFDAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15229  241 ASSSvlDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

25-291

6.95e-82

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 248.71 E-value: 6.95e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15232    1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15232   81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSP 263
Cdd:cd15232  161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRiRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 168229222 264 STHV--DKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15232  241 SYSPekDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

12-302

4.92e-80

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 244.88 E-value: 4.92e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  12 FVLLGLSNSWEIQVFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKV 91
Cdd:cd15410    1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  92 ISFGGCISQIFFSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGP 171
Cdd:cd15410   81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 172 NILDSFYCDIPRLVKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLF 250
Cdd:cd15410  161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRiRSAEGRQKAFSTCASHLTAITIF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 168229222 251 FGPLIFFYVCPSPST--HVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAIRKVF 302
Cdd:cd15410  241 HGTILFMYCRPSSSYslDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

27-298

2.20e-79

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 242.67 E-value: 2.20e-79

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  27 IFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHA 106
Cdd:cd15434    3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 107 VGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLVK 186
Cdd:cd15434   83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 187 LACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCP--SP 263
Cdd:cd15434  163 LACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKiKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPknSV 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 168229222 264 STHVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15434  243 SQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

35-297

2.07e-78

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 240.00 E-value: 2.07e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  35 YVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTEMVL 114
Cdd:cd15429   11 YLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEFIL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 115 LIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLVKLACTDTYK 194
Cdd:cd15429   91 LAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDTSL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 195 LELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPS--PSTHVDKFL 271
Cdd:cd15429  171 NEVAILVSSVVVLLTPCFLVLLSYIHIISAILRiRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRsgSSALQEKMI 250

                        250       260
                 ....*....|....*....|....*.
gi 168229222 272 AIFDAVLTPFLNPIIYTLRNRDMKIA 297
Cdd:cd15429  251 SLFYAVVTPMLNPLIYSLRNKEVKGA 276

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

25-300

5.41e-78

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 239.23 E-value: 5.41e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15409    1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15409   81 GFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTV-QKQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSP 263
Cdd:cd15409  161 LKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTIlKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 168229222 264 STHV--DKFLAIFDAVLTPFLNPIIYTLRNRDMKIAIRK 300
Cdd:cd15409  241 LYALdqDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

12-300

6.85e-78

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 239.26 E-value: 6.85e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  12 FVLLGLSNSWEIQVFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKV 91
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  92 ISFGGCISQIFFSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGP 171
Cdd:cd15945   81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 172 NILDSFYCDIPRLVKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLF 250
Cdd:cd15945  161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKiRSAEGRFKAFSTCASHLTAVGLF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 168229222 251 FGPLIFFYVCPSP--STHVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAIRK 300
Cdd:cd15945  241 YGTLLFMYLRPSSsySLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

25-291

7.38e-78

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 238.28 E-value: 7.38e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15431    1 IILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYIS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIhSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15431   81 LFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFL-LTVIPVLTMPLHFCGPNVINHFFCEVQAL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCS-SKALSTLLAHITVVVLFFGPLIFFYVCP-S 262
Cdd:cd15431  160 LKLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGrRKAFSTCGSHLTVVTIFYGTAIFMYLRPqS 239

                        250       260       270
                 ....*....|....*....|....*....|
gi 168229222 263 PSTH-VDKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15431  240 KSSSdQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

25-300

1.22e-77

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 238.08 E-value: 1.22e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15415    1 VPLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15415   81 AVFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSP 263
Cdd:cd15415  161 LKLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRiRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 168229222 264 STHVD--KFLAIFDAVLTPFLNPIIYTLRNRDMKIAIRK 300
Cdd:cd15415  241 QYSLEqeKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

24-291

1.46e-77

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 237.51 E-value: 1.46e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  24 QVFIFFFTCLfYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFF 103
Cdd:cd15918    1 QLLFGLFLGM-YLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 104 SHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPR 183
Cdd:cd15918   80 FLLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 184 LVKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPS 262
Cdd:cd15918  160 LLKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRiPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPP 239

                        250       260       270
                 ....*....|....*....|....*....|.
gi 168229222 263 PSTHVDKFL--AIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15918  240 SSHSASKDSvaAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

25-297

1.57e-77

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 238.00 E-value: 1.57e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15420    1 LLLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15420   81 LALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCP-- 261
Cdd:cd15420  161 LKLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKiQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPgs 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 168229222 262 SPSTHVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIA 297
Cdd:cd15420  241 SNSAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGA 276

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

27-298

4.78e-77

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 236.58 E-value: 4.78e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  27 IFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQ-KVISFGGCISQIFFSH 105
Cdd:cd15916    3 LFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFFH 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 106 AVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLV 185
Cdd:cd15916   83 FLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 186 KLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSPS 264
Cdd:cd15916  163 KLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRiRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSK 242

                        250       260       270
                 ....*....|....*....|....*....|....
gi 168229222 265 THVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15916  243 EALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

25-300

1.32e-76

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 235.67 E-value: 1.32e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15419    1 VLLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15419   81 SLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSP 263
Cdd:cd15419  161 LKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRiPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGA 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 168229222 264 --STHVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAIRK 300
Cdd:cd15419  241 vsSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

25-291

1.21e-74

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 230.34 E-value: 1.21e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15430    1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15430   81 LAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSS--GCsSKALSTLLAHITVVVLFFGPLIFFYVCPS 262
Cdd:cd15430  161 LKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSaeGR-KKAFSTCSAHLTVVIIFYGTILFMYMKPK 239

                        250       260       270
                 ....*....|....*....|....*....|.
gi 168229222 263 P--STHVDKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15430  240 SknAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

25-300

6.29e-74

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 228.74 E-value: 6.29e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15411    1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15411   81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSP 263
Cdd:cd15411  161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKiRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 168229222 264 STHV--DKFLAIFDAVLTPFLNPIIYTLRNRDMKIAIRK 300
Cdd:cd15411  241 SYSLgqDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

27-298

8.08e-74

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 228.47 E-value: 8.08e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  27 IFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHA 106
Cdd:cd15942    3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 107 VGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLVK 186
Cdd:cd15942   83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 187 LACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSG-CSSKALSTLLAHITVVVLFFGPLIFFYVCPSPST 265
Cdd:cd15942  163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAeGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD 242

                        250       260       270
                 ....*....|....*....|....*....|...
gi 168229222 266 HVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15942  243 PLDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

25-300

8.98e-74

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 228.41 E-value: 8.98e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15416    1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15416   81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSP 263
Cdd:cd15416  161 LKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRiRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 168229222 264 STHVD--KFLAIFDAVLTPFLNPIIYTLRNRDMKIAIRK 300
Cdd:cd15416  241 SYSMDqnKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

16-301

9.12e-74

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 228.79 E-value: 9.12e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  16 GLSNSWEIQVFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFG 95
Cdd:cd15406    1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  96 GCISQIFFSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILD 175
Cdd:cd15406   81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 176 SFYCDIPRLVKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTV-QKQSSGCSSKALSTLLAHITVVVLFFGPL 254
Cdd:cd15406  161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSIlRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 168229222 255 IFFYVCPSPSTHVD--KFLAIFDAVLTPFLNPIIYTLRNRDMKIAIRKV 301
Cdd:cd15406  241 IFMYLKPSSSSSMTqeKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

26-291

3.11e-73

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 226.40 E-value: 3.11e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  26 FIFFFtcLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSH 105
Cdd:cd15224    4 FLLFL--IAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 106 AVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLV 185
Cdd:cd15224   82 SLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 186 KLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCS-SKALSTLLAHITVVVLFFGPLIFFYVCPS-- 262
Cdd:cd15224  162 NLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGrQKAFSTCASHLTVVIIFYSATLFMYARPKai 241

                        250       260
                 ....*....|....*....|....*....
gi 168229222 263 PSTHVDKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15224  242 SSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

27-298

2.63e-71

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 221.97 E-value: 2.63e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  27 IFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHA 106
Cdd:cd15432    3 LFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 107 VGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLVK 186
Cdd:cd15432   83 LGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 187 LACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSPST 265
Cdd:cd15432  163 LSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRiRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNS 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 168229222 266 HVD--KFLAIFDAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15432  243 SHDrgKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

26-300

9.04e-71

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 220.73 E-value: 9.04e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  26 FIFFFtcLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSH 105
Cdd:cd15412    4 FVLFL--VIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 106 AVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLV 185
Cdd:cd15412   82 ALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 186 KLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSPS 264
Cdd:cd15412  162 KLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRiRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSE 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 168229222 265 THV--DKFLAIFDAVLTPFLNPIIYTLRNRDMKIAIRK 300
Cdd:cd15412  242 ESVeqSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

25-302

5.77e-70

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 218.83 E-value: 5.77e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15414    1 IPLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15414   81 GLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSP 263
Cdd:cd15414  161 LSLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRiRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 168229222 264 ST--HVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAIRKVF 302
Cdd:cd15414  241 SSslDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTI 281

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

25-298

1.37e-68

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 214.98 E-value: 1.37e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15424    1 ILLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15424   81 LSLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTV-QKQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCP-- 261
Cdd:cd15424  161 LKLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVlQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPrs 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 168229222 262 -SPSTHvDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15424  241 gSTPDR-DKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

25-291

1.68e-68

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 214.54 E-value: 1.68e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15914    1 LLLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15914   81 HSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSP 263
Cdd:cd15914  161 LSLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKiPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSK 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 168229222 264 STHV--DKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15914  241 SYSLdyDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

23-291

2.16e-68

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 214.10 E-value: 2.16e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  23 IQVFIFFFTClfYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIF 102
Cdd:cd15913    1 ILLFSFFSVI--YILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 103 FSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIP 182
Cdd:cd15913   79 FFFSLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 183 RLVKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSS-KALSTLLAHITVVVLFFGPLIFFYVCP 261
Cdd:cd15913  159 PLLALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRhKAFSTCGSHLAVVSLFYGSVMVMYVSP 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 168229222 262 SPSTHVD--KFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15913  239 GSGNSTGmqKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

25-298

6.00e-68

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 213.17 E-value: 6.00e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTcLFYVSSLTGNFIIVVTVTSDPYLHS-PMYFLLANLSVIDLIFCSIAAPKMICDLFRKQ-KVISFGGCISQIF 102
Cdd:cd15941    2 LFFLLFL-LIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 103 FSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIP 182
Cdd:cd15941   81 AFHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 183 RLVKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCP 261
Cdd:cd15941  161 PVLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRiRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQP 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 168229222 262 SPSTHVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15941  241 SSSQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

12-302

6.80e-67

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 211.18 E-value: 6.80e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  12 FVLLGLSNSWEIQVFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKV 91
Cdd:cd15944    1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  92 ISFGGCISQIFFSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGP 171
Cdd:cd15944   81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 172 NILDSFYCDIPRLVKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSS-KALSTLLAHITVVVLF 250
Cdd:cd15944  161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRrKAFSTCASHFTGVTLF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 168229222 251 FGPLIFFYVCPSP--STHVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAIRKVF 302
Cdd:cd15944  241 YGTVIFMYLRPTSvySLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

24-301

1.23e-66

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 210.02 E-value: 1.23e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  24 QVFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFF 103
Cdd:cd15418    1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 104 SHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPR 183
Cdd:cd15418   81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 184 LVKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPS 262
Cdd:cd15418  161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRiHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 168229222 263 PSTHV--DKFLAIFDAVLTPFLNPIIYTLRNRDMKIAIRKV 301
Cdd:cd15418  241 SSHTPdrDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

27-298

4.48e-66

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 208.49 E-value: 4.48e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  27 IFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHA 106
Cdd:cd15433    3 LFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 107 VGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLVK 186
Cdd:cd15433   83 LGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 187 LACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCP--SP 263
Cdd:cd15433  163 LACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRiKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPihRY 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 168229222 264 STHVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15433  243 SQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

23-300

1.50e-65

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 207.17 E-value: 1.50e-65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  23 IQVFIFFFtcLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIF 102
Cdd:cd15413    1 IPLFGLFL--VIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 103 FSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIP 182
Cdd:cd15413   79 FFLTFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 183 RLVKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTV-QKQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCP 261
Cdd:cd15413  159 PLLALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAIlRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQP 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 168229222 262 SpSTH---VDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAIRK 300
Cdd:cd15413  239 K-SSHsldTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

26-298

3.16e-65

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 206.27 E-value: 3.16e-65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  26 FIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSH 105
Cdd:cd15234    2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 106 AVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLV 185
Cdd:cd15234   82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 186 KLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSS-KALSTLLAHITVVVLFFGPLIFFYVCP--S 262
Cdd:cd15234  162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKyKAFSTCGSHLSVVSLFYGTGLGVYISSavT 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 168229222 263 PSTHVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15234  242 HSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

23-300

3.64e-65

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 206.12 E-value: 3.64e-65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  23 IQVFIFFftCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIF 102
Cdd:cd15407    1 IPLFIIF--TLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 103 FSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIP 182
Cdd:cd15407   79 FFVVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 183 RLVKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCP 261
Cdd:cd15407  159 PVLALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRmRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQP 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 168229222 262 SP--STHVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAIRK 300
Cdd:cd15407  239 SSshSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

27-298

1.46e-64

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 204.57 E-value: 1.46e-64

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  27 IFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHA 106
Cdd:cd15405    3 LFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 107 VGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLVK 186
Cdd:cd15405   83 FVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQ 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 187 LACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSG-CSSKALSTLLAHITVVVLFFGPLIFFYVCPSPST 265
Cdd:cd15405  163 LSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTeGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVG 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 168229222 266 HVD--KFLAIFDAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15405  243 SVNqgKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

25-291

8.54e-63

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 200.01 E-value: 8.54e-63

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFtcLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15946    3 LFAVFL--LIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15946   81 LALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCP-- 261
Cdd:cd15946  161 LKLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKiRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPgs 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 168229222 262 SPSTHVDKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd15946  241 NYSPERDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

23-298

9.65e-63

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 200.01 E-value: 9.65e-63

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  23 IQVFIFFFtcLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIF 102
Cdd:cd15428    1 ILLFILFL--IIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 103 FSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIP 182
Cdd:cd15428   79 FFLSFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 183 RLVKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTV-QKQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCP 261
Cdd:cd15428  159 ALLKLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVfGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRP 238

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 168229222 262 --SPSTHVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15428  239 ksSTSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

35-298

1.08e-60

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 194.60 E-value: 1.08e-60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  35 YVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTEMVL 114
Cdd:cd15236   11 YLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSFL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 115 LIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLVKLACTDTYK 194
Cdd:cd15236   91 LAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTSL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 195 LELMITANSGFISLIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPS--PSTHVDKFL 271
Cdd:cd15236  171 NELVIFTEGGLLFVLPLLLILGSYIRIAATILKvPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSsnNSSDKDIVA 250

                        250       260
                 ....*....|....*....|....*..
gi 168229222 272 AIFDAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15236  251 SVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

26-298

1.23e-58

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 189.62 E-value: 1.23e-58

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  26 FIFFFTCLF-YVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15233    1 PVLFVTFLLaYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15233   81 HLLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTV-QKQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCPSP 263
Cdd:cd15233  161 FQLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVlRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 168229222 264 --STHVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15233  241 vySSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

32-298

1.89e-50

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 168.24 E-value: 1.89e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  32 CLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTE 111
Cdd:cd15223    8 LLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAME 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 112 MVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLVKLACTD 191
Cdd:cd15223   88 SSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACGD 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 192 TYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCS-SKALSTLLAHITVVVLFFGPLIFFYVC----PSPSTH 266
Cdd:cd15223  168 TTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEArSKALNTCGSHLIVILFFYTAVLVSSLTyrfgKTIPPD 247

                        250       260       270
                 ....*....|....*....|....*....|..
gi 168229222 267 VDKFLAIFDAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15223  248 VHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

25-292

1.49e-49

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 165.93 E-value: 1.49e-49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15221    1 VWISIPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15221   81 HFVFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDtyklelmITANSGFISLIAF-------FLLIISYVFLLTTV-QKQSSGCSSKALSTLLAHITVVVLFFGPLIF 256
Cdd:cd15221  161 ARLACAD-------ITVNIWYGLTVALltvgldvVLIAVSYALILRAVfRLPSKDARLKALSTCGSHVCVILMFYTPAFF 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 168229222 257 FYVC----PSPSTHVDKFLAIFDAVLTPFLNPIIYTLRNR 292
Cdd:cd15221  234 SFLThrfgRHIPRHVHILLANLYVLVPPMLNPIVYGVKTK 273

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

25-292

1.61e-48

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 163.35 E-value: 1.61e-48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15950    1 FWIAIPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15950   81 HSFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSS-KALSTLLAHITVVVLFFGPLIFFYVCPSP 263
Cdd:cd15950  161 VKLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARlKAFSTCGSHVCVILLFYIPGLLSIYTQRF 240

                        250       260       270
                 ....*....|....*....|....*....|...
gi 168229222 264 ST----HVDKFLAIFDAVLTPFLNPIIYTLRNR 292
Cdd:cd15950  241 GQgvppHTQVLLADLYLLVPPMLNPIIYGMRTK 273

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

25-292

7.55e-48

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 161.39 E-value: 7.55e-48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15952    1 FWIGFPFCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15952   81 HTFTGMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDtykLELMITANSGFISLIAF--FLLIISYVFLLTTVQKQSSGCSS-KALSTLLAHITVVVLFFGPLIFFYVCP 261
Cdd:cd15952  161 AKLACAS---IRINIIYGLFAISVLVLdvILIALSYVLILRAVFRLPSHDARlKALSTCGSHVCVILAFYTPALFSFLTH 237

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 168229222 262 SPSTHVDKFLAIFDA----VLTPFLNPIIYTLRNR 292
Cdd:cd15952  238 RFGHNIPRYIHILLAnlyvVLPPMLNPVIYGVRTK 272

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

27-294

1.09e-47

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 160.92 E-value: 1.09e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  27 IFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHA 106
Cdd:cd15917    3 LSIPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 107 VGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLVK 186
Cdd:cd15917   83 FTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 187 LACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSG-CSSKALSTLLAHITVVVLFFGPLIFFYV------ 259
Cdd:cd15917  163 LACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKeARLKALSTCGSHICVILIFYTPALFSFLthrfgh 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 168229222 260 CPSPSTHVdkFLAIFDAVLTPFLNPIIYTLRNRDM 294
Cdd:cd15917  243 HVPPHVHI--LLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

32-292

2.80e-46

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 157.43 E-value: 2.80e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  32 CLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTE 111
Cdd:cd15953    8 CLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIME 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 112 MVLLIAMAFDRYVAICKPLRYLTIMS-PRMCLLILVAAwIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLVKLACT 190
Cdd:cd15953   88 SAVLVAMAFDRYVAICNPLRYATILTnSRIAKLGLVGL-IRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 191 DT-----YKLELMITANSGFISLIAfflliISYVFLLTTVQKQSS-GCSSKALSTLLAHITVVVLFFGPLIFFYVCP--- 261
Cdd:cd15953  167 DTtinriYGLVVALLVVGLDLLLIA-----LSYALIIRAVLRLSSkKARQKALNTCTAHICVILMSYTPALFSFLTHrfg 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 168229222 262 ---SPSTHVdkFLAIFDAVLTPFLNPIIYTLRNR 292
Cdd:cd15953  242 qgiAPHIHI--ILANLYLLVPPMLNPIIYGVKTK 273

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

27-292

4.91e-46

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 156.89 E-value: 4.91e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  27 IFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHA 106
Cdd:cd15222    3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 107 VGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLVK 186
Cdd:cd15222   83 FSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 187 LACTDT-----YKLELMItansgFISLIAFFLLIISYVFLLTTVQKQSSGCSS-KALSTLLAHITVVVLFFGPLIF---- 256
Cdd:cd15222  163 LACSDTrvnsiYGLFVVL-----STMGLDSLLILLSYVLILKTVLGIASREERlKALNTCVSHICAVLIFYVPMIGlsmv 237

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 168229222 257 --FYVCPSPSTHVdkFLAIFDAVLTPFLNPIIYTLRNR 292
Cdd:cd15222  238 hrFGKHASPLVHV--LMANVYLLVPPVLNPIIYSVKTK 273

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

25-292

6.36e-45

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 154.04 E-value: 6.36e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15951    1 VWISIPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15951   81 HSFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTyklelmiTANSGFISLIAF-------FLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGPLIF 256
Cdd:cd15951  161 VKLACADT-------RVSRAYGLSVAFlvggldvIFIAVSYIQILRAVFKlPSKEARLKTFGTCGSHICVILVFYIPALF 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 168229222 257 FYVCPSPSTHVDKFLAIFDA----VLTPFLNPIIYTLRNR 292
Cdd:cd15951  234 SFLTHRFGHNVPPHVHILIAnvylLVPPMLNPIIYGVRTK 273

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

32-295

6.76e-41

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 143.51 E-value: 6.76e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  32 CLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTE 111
Cdd:cd15948    9 CSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIME 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 112 MVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLVKLACTD 191
Cdd:cd15948   89 SAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACGD 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 192 TYKLELMITANSGFISLIAFFLLIISYVFLLTTV-QKQSSGCSSKALSTLLAHITVVVLFFGPLIF----FYVCPSPSTH 266
Cdd:cd15948  169 TRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVlSLASKEEQLKAFGTCGSHICAILVFYTPVVLsstmHRFARHVAPH 248

                        250       260
                 ....*....|....*....|....*....
gi 168229222 267 VDKFLAIFDAVLTPFLNPIIYTLRNRDMK 295
Cdd:cd15948  249 VHILLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

10-295

1.80e-37

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 134.90 E-value: 1.80e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  10 SEFVLLGLSNSWEIQVFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQ 89
Cdd:cd15949    2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  90 KVISFGGCISQIFFSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFC 169
Cdd:cd15949   82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 170 GPNILDSFYCDIPRLVKLACTDTyKLELMITANSGFISLIAFFLLI-ISYVFLLTTVQK-QSSGCSSKALSTLLAHITVV 247
Cdd:cd15949  162 RTNIIAHSYCEHMAVVGLACGDV-SINNHYGLTIGFLVLIMDSLFIvLSYIMILRVVQRlATSEARLKTFGTCVSHVCAI 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 168229222 248 VLFFGPLIF------FYVCPSPSTHVdkFLAIFDAVLTPFLNPIIYTLRNRDMK 295
Cdd:cd15949  241 LAFYVPIAVsslihrFGQNVPPPTHI--LLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

32-303

2.02e-33

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 123.77 E-value: 2.02e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222   32 CLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTE 111
Cdd:pfam13853   2 CLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIME 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  112 MVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLVKLACTD 191
Cdd:pfam13853  82 SAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCAD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  192 -----TYKLeLMITANSGFISLiaffLLIISYVFLLTTVQKQSSGCSS-KALSTLLAHITVVVLFFGPLIFFYVCPSPST 265
Cdd:pfam13853 162 ikvnnIYGL-FVVTSTFGIDSL----LIVLSYGLILRTVLGIASREGRlKALNTCGSHVCAVLAFYTPMIGLSMVHRFGH 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 168229222  266 HVDKFLAIFDA----VLTPFLNPIIYTLRNRDMKIAIRKVFC 303
Cdd:pfam13853 237 NVPPLLQIMMAnaylFFPPVLNPIVYSVKTKQIRDCVKRMLL 278

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

25-294

2.70e-33

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 123.39 E-value: 2.70e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15954    1 IWISIPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRL 184
Cdd:cd15954   81 HTFTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSG-CSSKALSTLLAHITVVVLFFGPLIF-FYVCPS 262
Cdd:cd15954  161 VKLACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKeARSKAFSTCTAHICAIVITYTPAFFtFFAHRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 168229222 263 PSTHVDKFLAIFDA----VLTPFLNPIIYTLRNRDM 294
Cdd:cd15954  241 GGHHITPHIHIIMAnlylLLPPMMNPIVYGVKTKQI 276

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

32-294

5.23e-33

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 122.67 E-value: 5.23e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  32 CLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTE 111
Cdd:cd15956    8 CFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAME 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 112 MVLLIAMAFDRYVAICKPLRYLTIMSPRMC-----LLILVAAWIIGLIHSsaqlaFVINLPFCGPNILDSFYCDIPRLVK 186
Cdd:cd15956   88 SGVLVAMALDRFVAICNPLHYATILTLEVVakaglLLALRGVAIVIPFPL-----LVCRLSFCASHTIAHTYCEHMAVVK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 187 LACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTV-QKQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVC----P 261
Cdd:cd15956  163 LACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVlRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMhrfgH 242

                        250       260       270
                 ....*....|....*....|....*....|...
gi 168229222 262 SPSTHVDKFLAIFDAVLTPFLNPIIYTLRNRDM 294
Cdd:cd15956  243 SVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

41-287

2.64e-30

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 115.09 E-value: 2.64e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222   41 GNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICD-LFRKQKVISFGGCISQIFFSHAVGGTEMVLLIAMA 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYyLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  120 FDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNildSFYCDIPRLvklacTDTYKLELMI 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFP-----EDLSKPVSYT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  200 TANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSS--------KALSTLLAHITVVVLFFGPLIFFYVCPS------PST 265
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSsertqrrrKALKTLAVVVVVFILCWLPYHIVNLLDSlaldceLSR 232

                         250       260
                  ....*....|....*....|....
gi 168229222  266 HVDKFLAIFD--AVLTPFLNPIIY 287
Cdd:pfam00001 233 LLDKALSVTLwlAYVNSCLNPIIY 256

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

32-294

4.34e-27

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 107.16 E-value: 4.34e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  32 CLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTE 111
Cdd:cd15955    8 CIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 112 MVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFV-INLPFCGPNILDSFYCDIPRLVKLACT 190
Cdd:cd15955   88 SGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIkLRLHHFRSTVISHSYCEHMAVVKLAAD 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 191 DTYKLELMITANSGFISLIAFFLLIISYVFLLTTV-QKQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVCP------SP 263
Cdd:cd15955  168 DVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVfRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHrfghhvAP 247

                        250       260       270
                 ....*....|....*....|....*....|.
gi 168229222 264 STHVdkFLAIFDAVLTPFLNPIIYTLRNRDM 294
Cdd:cd15955  248 YVHI--LLSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

27-291

8.29e-21

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 90.04 E-value: 8.29e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  27 IFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHA 106
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 107 VGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLVk 186
Cdd:cd00637   81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSK- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 187 lactdtykleLMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSS---------------KALSTLLAHITVVVLFF 251
Cdd:cd00637  160 ----------AYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSsssnssrrrrrrrerKVTKTLLIVVVVFLLCW 229

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 168229222 252 GPLIFFYVCPSPSTHVDKFLAIFD------AVLTPFLNPIIYTLRN 291
Cdd:cd00637  230 LPYFILLLLDVFGPDPSPLPRILYflalllAYLNSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

30-298

5.08e-15

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 73.37 E-value: 5.08e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  30 FTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGG 109
Cdd:cd14967    5 FLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 110 TEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSaqLAFVINLPFCGPNILDSFYCDIPrlvklac 189
Cdd:cd14967   85 ASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISL--PPLVGWRDETQPSVVDCECEFTP------- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 190 TDTYKLelmitansgFISLIAFFL----LIISYVFLLTTVQKQssgcsSKALSTLLAHITVVVL----FFGPLIFFYVCP 261
Cdd:cd14967  156 NKIYVL---------VSSVISFFIplliMIVLYARIFRVARRE-----LKAAKTLAIIVGAFLLcwlpFFIIYLVSAFCP 221

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 168229222 262 SPSTHVDKFLAIF-DAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd14967  222 PDCVPPILYAVFFwLGYLNSALNPIIYALFNRDFRRAF 259

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

25-298

4.48e-13

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 68.00 E-value: 4.48e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFyVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd14969    2 VLAVYLSLIG-VLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYlTIMSPRMCLLILVAAWIIGLIHSSAqlafvinlPFCGPN--ILDSFY--CD 180
Cdd:cd14969   81 TFLGLVSISTLAALAFERYLVIVRPLKA-FRLSKRRALILIAFIWLYGLFWALP--------PLFGWSsyVPEGGGtsCS 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 181 IPRLVKLACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVC 260
Cdd:cd14969  152 VDWYSKDPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTKKAEKKVAKMVLVMIVAFLIA 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 168229222 261 PSPSTHVDKFLAIFDAVLTP---------------FLNPIIYTLRNRDMKIAI 298
Cdd:cd14969  232 WTPYAVVSLYVSFGGESTIPpllatipalfaksstIYNPIIYVFMNKQFRRAL 284

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

25-164

1.79e-09

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 57.69 E-value: 1.79e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKqKVISFGG--CISQIF 102
Cdd:cd14997    1 VLVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAR-EPWLLGEfmCKLVPF 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 168229222 103 FSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVI 164
Cdd:cd14997   80 VELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITE 141

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

25-226

6.28e-09

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 56.07 E-value: 6.28e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFyVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAP-KMICDLFRkqkVISFGG--CISQI 101
Cdd:cd14993    2 VLIVLYVVVF-LLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPlTLLENVYR---PWVFGEvlCKAVP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 102 FFSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIglihssaqlAFVINLPFCGPNILDSFYCDI 181
Cdd:cd14993   78 YLQGVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVI---------AIIIMLPLLVVYELEEIISSE 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 168229222 182 P-RLVKLACTDTYKLELMITANSGFISLIAFF--LLIISYVFLLTTVQ 226
Cdd:cd14993  149 PgTITIYICTEDWPSPELRKAYNVALFVVLYVlpLLIISVAYSLIGRR 196

7tmA_NPYR-like

cd15203

neuropeptide Y receptors and related proteins, member of the class A family of ...

25-157

1.41e-08

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.

Pssm-ID: 320331 [Multi-domain] Cd Length: 293 Bit Score: 54.92 E-value: 1.41e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQ--------KVISFGG 96
Cdd:cd15203    1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNwpfgsilcKLVPSLQ 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 168229222  97 CISqIFFShavggteMVLLIAMAFDRYVAICKPLRylTIMSPRMCLLILVAAWIIGLIHSS 157
Cdd:cd15203   81 GVS-IFVS-------TLTLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLSL 131

7tmA_capaR

cd15134

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...

32-289

1.72e-08

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.

Pssm-ID: 320262 [Multi-domain] Cd Length: 298 Bit Score: 54.64 E-value: 1.72e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  32 CLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQK-VISFGGCISQIFFSHAVGGT 110
Cdd:cd15134    8 GIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQYPwVFGEVFCKLRAFLSEMSSYA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 111 EMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHS-----SAQLAFVINLPFCGPNILDSFYCDIPRlv 185
Cdd:cd15134   88 SVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCAlpfaiQTRIVYLEYPPTSGEALEESAFCAMLN-- 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 186 klactdTYKLELMITANSGFIsliaFFLL---IISYVFLL-------TTVQKQSSGCSSKALSTLLAHITVVVLFFGPLI 255
Cdd:cd15134  166 ------EIPPITPVFQLSTFL----FFIIpmiAIIVLYVLiglqlrrSTLLRRGQRSVSGGRRSSQSRRTVLRMLVAVVV 235

                        250       260       270
                 ....*....|....*....|....*....|....
gi 168229222 256 FFYVCPSPsTHVDKFLAIFDAVLTPFLNPIIYTL 289
Cdd:cd15134  236 AFFICWAP-FHAQRLLTVYAKNMTPPYLFINRIL 268

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

23-227

2.46e-08

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 54.18 E-value: 2.46e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  23 IQVFIFFFTCLFyvsSLTGNFIIVVTVTSdPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGG-----C 97
Cdd:cd14978    2 LYGYVLPVICIF---GIIGNILNLVVLTR-KSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYfyayfL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  98 ISQIFFSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSF 177
Cdd:cd14978   78 PYIYPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYY 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 168229222 178 YCDIPRLVKlacTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQK 227
Cdd:cd14978  158 YVIPTLLRQ---NETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRK 204

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

27-160

3.77e-08

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 53.57 E-value: 3.77e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  27 IFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHA 106
Cdd:cd15336    3 VGSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGAL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 168229222 107 VGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQL 160
Cdd:cd15336   83 FGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPL 136

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

33-160

4.46e-08

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 53.49 E-value: 4.46e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  33 LFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTEM 112
Cdd:cd15083    9 IIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSI 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 168229222 113 VLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQL 160
Cdd:cd15083   89 NTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPL 136

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

21-175

1.34e-07

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 51.85 E-value: 1.34e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  21 WEI--QVFIFFFTclfyvssLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLI--FCSIAaPKMICDL-FRKQ------ 89
Cdd:cd15196    2 VEIavLATILVLA-------LFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLvaLFNVL-PQLIWDItYRFYggdllc 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  90 KVISFGgcisQIFFSHAvggtEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVaAWIIGLIHSSAQLaFVINLPFC 169
Cdd:cd15196   74 RLVKYL----QVVGMYA----SSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAI-AWVLSLLLSIPQL-FIFSYQEV 143


                 ....*.
gi 168229222 170 GPNILD 175
Cdd:cd15196  144 GSGVYD 149

7tmA_GPRnna14-like

cd15001

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...

39-287

1.46e-07

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320132 [Multi-domain] Cd Length: 266 Bit Score: 51.51 E-value: 1.46e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  39 LTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTEMVLLIAM 118
Cdd:cd15001   14 LIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFICSVLTLTAI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 119 AFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCdiprlvKLACTDTYKLELM 198
Cdd:cd15001   94 SIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTVYHC------QKAWPSTLYSRLY 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 199 ITANSGFISLIAFFLLIISYVfllttvqkqsSGCSSKALSTLLAHITVVVLFFGPLI-------FFYVCPSPSTHVdKFL 271
Cdd:cd15001  168 VVYLAIVIFFIPLIVMTFAYA----------RDTRKQVIKMLISVVVLFAVCWGPLLidnllvsFDVISTLHTQAL-KYM 236

                        250
                 ....*....|....*....
gi 168229222 272 AIFDAVLTPF---LNPIIY 287
Cdd:cd15001  237 RIAFHLLSYAnscINPIIY 255

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

29-165

3.48e-07

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 50.65 E-value: 3.48e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  29 FFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCsIAAPKMICDLFRKQKVISFGGCISQIFFSHAVG 108
Cdd:cd15079    5 FIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMM-IKMPIFIYNSFYEGWALGPLGCQIYAFLGSLSG 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 168229222 109 GTEMVLLIAMAFDRYVAICKPLRyLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVIN 165
Cdd:cd15079   84 IGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYALPWALLPLLFGWG 139

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

34-160

4.71e-07

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 50.28 E-value: 4.71e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  34 FYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPkmICDLFRKQKVISFGGCISQIFFSHAV--GGTE 111
Cdd:cd15325   10 FILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLP--FSAIFEILGYWAFGRVFCNIWAAVDVlcCTAS 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 168229222 112 MVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQL 160
Cdd:cd15325   88 IMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPL 136

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

29-294

6.61e-07

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 49.60 E-value: 6.61e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  29 FFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIfcsiaapkmicdlfrkQKVISFGGCISQIFFSHAVG 108
Cdd:cd14972    3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLL----------------AGIAFVFTFLSVLLVSLTPS 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 109 GTEMVL---------------LIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIhssaqlafVINLPFCGPNI 173
Cdd:cd14972   67 PATWLLrkgslvlsllasaysLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVL--------LALLPVLGWNC 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 174 LDsfyCDIPRLVKLACTDTYKLELMITAnsgfISLIAFFLLIISYVFLLTTVQKQSSGCSSKALSTLLAH--------IT 245
Cdd:cd14972  139 VL---CDQESCSPLGPGLPKSYLVLILV----FFFIALVIIVFLYVRIFWCLWRHANAIAARQEAAVPAQpstsrklaKT 211

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 168229222 246 VVVLffgpLIFFYVCPSPS---------------THVDKFLAIFDAVLTPFLNPIIYTLRNRDM 294
Cdd:cd14972  212 VVIV----LGVFLVCWLPLlillvldvlcpsvcdIQAVFYYFLVLALLNSAINPIIYAFRLKEM 271

7tmA_Opsin_Gq_invertebrates

cd15337

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...

36-298

8.37e-07

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320459 [Multi-domain] Cd Length: 292 Bit Score: 49.63 E-value: 8.37e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  36 VSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFC-SIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTEMVL 114
Cdd:cd15337   12 ILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSaVNGFPLKTISSFNKKWIWGKVACELYGFAGGIFGFMSITT 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 115 LIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSaqlafvinLPFC--GPNILDSFY--CDIPRLVKLACT 190
Cdd:cd15337   92 LAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSI--------PPFFgwGRYVPEGFQtsCTFDYLSRDLNN 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 191 DTYKLELMITansGFisLIAFFLLIISYVFLLTTVQKQ----------------SSGCSSKALSTLLAHITVVVLFfgpl 254
Cdd:cd15337  164 RLFILGLFIF---GF--LCPLLIIIFCYVNIIRAVRNHekemtqtaksgmgkdtEKNDARKKAEIRIAKVAIILIS---- 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 255 iFFYVCPSPSTHVdKFLAIF--DAVLTPFL--------------NPIIYTLRNRDMKIAI 298
Cdd:cd15337  235 -LFLLSWTPYAVV-ALLGQFgpAYWITPYVselpvmfakasaiyNPIIYALSHPKFRAAL 292

7tmA_D2-like_dopamine_R

cd15053

D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...

30-302

1.52e-06

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320181 [Multi-domain] Cd Length: 263 Bit Score: 48.50 E-value: 1.52e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  30 FTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAP---------------KMICDLFRKQKVISf 94
Cdd:cd15053    6 FLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPfavyvevnggkwylgPILCDIYIAMDVMC- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  95 ggCISQIFfshavggtemvLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIiglihssaqLAFVINLP-FCGPNI 173
Cdd:cd15053   85 --STASIF-----------NLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWV---------VSAAIACPlLFGLNN 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 174 ldsfycdiprlvklacTDTYKLELMITANSGFI---SLIAFFL--LIISYVFLLTTVQKQSSGCSSKALSTLLAHITVVV 248
Cdd:cd15053  143 ----------------VPYRDPEECRFYNPDFIiysSISSFYIpcIVMLLLYYRIFRALRREKKATKTLAIVLGVFLFCW 206

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 168229222 249 L-FFGPLIFFYVCP---SPSTHVDK---FLAIFDAVLTPFLNPIIYTLRNrdmkIAIRKVF 302
Cdd:cd15053  207 LpFFTLNILNAICPklqNQSCHVGPalfSLTTWLGYVNSFLNPIIYTIFN----IEFRKAF 263

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

30-156

2.01e-06

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 48.51 E-value: 2.01e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  30 FTCLFyVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPkmiCDLFRKQKVISF----GGCISQIFFSH 105
Cdd:cd14979    7 YVAIF-VVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLP---VELYNFWWQYPWafgdGGCKLYYFLFE 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 168229222 106 AVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHS 156
Cdd:cd14979   83 ACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCA 133

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

26-156

4.94e-06

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 47.35 E-value: 4.94e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  26 FIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAP-KMICDLFRKQkviSFGGCISQIFFS 104
Cdd:cd15065    1 LIGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTfAVVNDLLGYW---LFGETFCNIWIS 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 168229222 105 HAVG-GTEMVL-LIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHS 156
Cdd:cd15065   78 FDVMcSTASILnLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALIS 131

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

38-176

6.34e-06

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 46.85 E-value: 6.34e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  38 SLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQkvISFGGCISQIFFSHAVGGTEMVLLIA 117
Cdd:cd15069   14 SVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFC--TDFHSCLFLACFVLVLTQSSIFSLLA 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 118 MAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIiglihssaqLAFVINL-PFCGPNILDS 176
Cdd:cd15069   92 VAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWV---------LAFGIGLtPFLGWNKAMS 142

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

32-220

6.64e-06

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 46.67 E-value: 6.64e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  32 CLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDL---IFCSIaaPKMICDLFRKQKVISFgGCISQIFFSHAVG 108
Cdd:cd15012    7 TLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLcvgIFCVL--QNLSIYLIPSWPFGEV-LCRMYQFVHSLSY 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 109 GTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSfycdiprlVKLA 188
Cdd:cd15012   84 TASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQE--------EEIC 155

                        170       180       190
                 ....*....|....*....|....*....|..
gi 168229222 189 CTDTYKLELMITANSGFISLIAFFLLIISYVF 220
Cdd:cd15012  156 VLDREMFNSKLYDTINFIVWYLIPLLIMTVLY 187

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

32-175

7.02e-06

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 46.73 E-value: 7.02e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  32 CLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAA-PKMICDL-FRKQKVISFGGCISQIFFSHAVGG 109
Cdd:cd15387    8 ALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFQVlPQLIWDItFRFYGPDFLCRLVKYLQVVGMFAS 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 168229222 110 TEMVLLiaMAFDRYVAICKPLRYLTIMSPRMCLLilvAAWIIGLIHSSAQLaFVINLPFCGPNILD 175
Cdd:cd15387   88 TYMLLL--MSIDRCLAICQPLRSLHRRSDRVYVL---FSWLLSLVFSIPQV-HIFSLREVGNGVYD 147

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

36-150

7.14e-06

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 46.71 E-value: 7.14e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  36 VSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFC--------SIAAPKMICDLFRKQKVISFGGCISQIFFSHAV 107
Cdd:cd15103   12 IVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSvsnaletiVIILLNNGYLVPRDSFEQHIDNVIDSMICSSLL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 168229222 108 GgtEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWI 150
Cdd:cd15103   92 A--SICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWV 132

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

32-161

8.99e-06

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 46.60 E-value: 8.99e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  32 CLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQ--------KVISFGgcisQIFF 103
Cdd:cd14986    8 GVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEwvagdvlcRIVKYL----QVVG 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 168229222 104 SHAvggtEMVLLIAMAFDRYVAICKPLRYLTimSPRMCLLILVAAWIIGLIHSSAQLA 161
Cdd:cd14986   84 LFA----STYILVSMSLDRYQAIVKPMSSLK--PRKRARLMIVVAWVLSFLFSIPQLV 135

7tmA_GPR84-like

cd15210

G protein-coupled receptor 84 and similar proteins, member of the class A family of ...

31-153

1.01e-05

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.

Pssm-ID: 320338 [Multi-domain] Cd Length: 254 Bit Score: 46.10 E-value: 1.01e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  31 TCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGT 110
Cdd:cd15210    7 GIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAV 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 168229222 111 EMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGL 153
Cdd:cd15210   87 SLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSF 129

PHA03087

G protein-coupled chemokine receptor-like protein; Provisional

27-253

1.01e-05

G protein-coupled chemokine receptor-like protein; Provisional

Pssm-ID: 222976 [Multi-domain] Cd Length: 335 Bit Score: 46.31 E-value: 1.01e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  27 IFFFTCLFYVSSLTGNfIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAaPKMICDLFRKQkvISFGGCISQI--FFS 104
Cdd:PHA03087  43 LIVVYSTIFFFGLVGN-IIVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTL-PFQIYYYILFQ--WSFGEFACKIvsGLY 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDiprl 184
Cdd:PHA03087 119 YIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNN---- 194

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 168229222 185 vklactDTYKLELMITANSGFIS-LIAFFLLIISYVFLLTTVQK-QSSGCSSKALSTLLAHITVVVLFFGP 253
Cdd:PHA03087 195 ------KTMNWKLFINFEINIIGmLIPLTILLYCYSKILITLKGiNKSKKNKKAIKLVLIIVILFVIFWLP 259

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

33-150

1.10e-05

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 45.81 E-value: 1.10e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  33 LFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAP---------------KMICDLFRKQKVISFGGC 97
Cdd:cd15067    8 LFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPfsilhemtggywlfgRDWCDVWHSFDVLASTAS 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 168229222  98 ISQiffshavggtemvlLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWI 150
Cdd:cd15067   88 ILN--------------LCVISLDRYWAITDPISYPSRMTKRRALIMIALVWI 126

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

31-297

1.32e-05

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 45.83 E-value: 1.32e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  31 TCLFYVSSLTGNFIIVVTVTSDPYL-HSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGG 109
Cdd:cd15104    6 LAVLSPLIITGNLLVIVALLKLIRKkDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITSCA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 110 TEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYCDIPRLvklac 189
Cdd:cd15104   86 ASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLISPQFQQTSYKGKCSFFAAFHPRV----- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 190 tdtykleLMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSS----------------KALSTLLAHITVVVLFFGP 253
Cdd:cd15104  161 -------LLVLSCMVFFPALLLFVFCYCDILKIARVHSRAIYKVEhalarqihprrtlsdfKAARTVAVLIGCFLLSWLP 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 168229222 254 lifFYVC-----PSPSTHVDKFLAIFDAVLTPF---LNPIIYTLRNRDMKIA 297
Cdd:cd15104  234 ---FQITglvqaLCDECKLYDVLEDYLWLLGLCnslLNPWIYAFWQKEVRRA 282

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

38-149

1.58e-05

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 45.91 E-value: 1.58e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  38 SLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLfRKQKVISFG--GCISQIFFSHAVGGTEMVLL 115
Cdd:cd15005   14 SLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASV-RHGSGWIYGalSCKVIAFLAVLFCFHSAFTL 92

                         90       100       110
                 ....*....|....*....|....*....|....
gi 168229222 116 IAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAW 149
Cdd:cd15005   93 FCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAW 126

7tmA_alpha1B_AR

cd15326

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

34-297

1.73e-05

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320449 [Multi-domain] Cd Length: 261 Bit Score: 45.27 E-value: 1.73e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  34 FYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAP--------------KMICDLFRKQKVISfggCIS 99
Cdd:cd15326   10 FILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPfsatleilgywvfgRIFCDIWAAVDVLC---CTA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 100 QIFFshavggtemvlLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLafvinLPFCGPNILDSFYC 179
Cdd:cd15326   87 SILS-----------LCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPL-----LGWKEPAPPDDKVC 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 180 DIprlvklacTDTYKLELMITANSGFISLIaffLLIISYVFLLTTVQKQSSgcSSKALSTLLAHITVVVLFFGPliFFYV 259
Cdd:cd15326  151 EI--------TEEPFYALFSSLGSFYIPLI---VILVMYCRVYIVALKFSR--EKKAAKTLGIVVGMFILCWLP--FFIA 215

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 168229222 260 CP--SPSTHVDKFLAIFDAV-----LTPFLNPIIYTLRNRDMKIA 297
Cdd:cd15326  216 LPlgSLFSHLKPPETLFKIIfwlgyFNSCLNPIIYPCSSKEFKRA 260

7tmA_Prostanoid_R

cd14981

G protein-coupled receptors for prostanoids, member of the class A family of ...

94-263

2.07e-05

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.

Pssm-ID: 320112 [Multi-domain] Cd Length: 288 Bit Score: 45.31 E-value: 2.07e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  94 FGGCISQIFFShavggtEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSaqlafvinLPFCGPNI 173
Cdd:cd14981   79 FGFMMSFFGLS------SLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIAS--------LPLLGLGS 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 174 LDSFY----CDIprlvklactDTYKLELMITANSGFISLIAFFLLIISYVFLLTTV---------QKQSSGCSSKALSTL 240
Cdd:cd14981  145 YVLQYpgtwCFL---------DFYSKNTGDAAYAYLYSILGLLILLVTLLCNLLVIitllrmrrrKKRHRRSRRSARRQK 215

                        170       180
                 ....*....|....*....|...
gi 168229222 241 LAHITVVVLFFGPLIFFYVCPSP 263
Cdd:cd14981  216 RNEIQMVVLLLAITVVFSVCWLP 238

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

25-289

2.12e-05

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 45.24 E-value: 2.12e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVID-LIFCSIAAPKMI-------------CDLFrkqK 90
Cdd:cd15055    1 VLLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADfLVGLLVMPFSMIrsietcwyfgdtfCKLH---S 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  91 VISFGGCISQIFfshavggtEMVLLiamAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLafVINLPFCG 170
Cdd:cd15055   78 SLDYILTSASIF--------NLVLI---AIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLL--YDNLNQPG 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 171 PNILDSFYCDiprlvklaCTdtykleLMITANSGFISLIAFFLL-----IISY--VFL--------LTTVQKQSSGCSS- 234
Cdd:cd15055  145 LIRYNSCYGE--------CV------VVVNFIWGVVDLVLTFILpctvmIVLYmrIFVvarsqaraIRSHTAQVSLEGSs 210

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 168229222 235 ---------KALSTLLAHITVVVLFFGPlifFYVCpspsTHVDKFLAIFDAVLTPF---------LNPIIYTL 289
Cdd:cd15055  211 kkvskkserKAAKTLGIVVGVFLLCWLP---YYIV----SLVDPYISTPSSVFDVLiwlgyfnscLNPLIYAL 276

7tmA_MCHR-like

cd15088

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...

36-289

2.35e-05

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320216 [Multi-domain] Cd Length: 278 Bit Score: 45.14 E-value: 2.35e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  36 VSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCsIAAPKMICDLFRkQKVISFGGCISQIFFSHAVGG--TEMV 113
Cdd:cd15088   12 VVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFM-LGMPFLIHQFAI-DGQWYFGEVMCKIITALDANNqfTSTY 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 114 LLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFcgPNILDSFYCDIPRLVKLactDTY 193
Cdd:cd15088   90 ILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYF--PDGTTFCYVSLPSPDDL---YWF 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 194 KLELMITANSGFISLI-AFFLLIISYVFLLTTVQKQSSGcSSKALSTLLAHITVVVLFFGPLIFFYVC---------PSP 263
Cdd:cd15088  165 TIYHFILGFAVPLVVItVCYILILHRLARGVAPGNQSHG-SSRTKRVTKMVILIVVVFIVCWLPFHVVqlvnlamnrPTL 243

                        250       260
                 ....*....|....*....|....*.
gi 168229222 264 STHVDKFLAIFDAVLTPFLNPIIYTL 289
Cdd:cd15088  244 AFEVAYFLSICLGYANSCLNPFVYIL 269

7tmA_S1PR

cd15102

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...

42-298

2.43e-05

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320230 [Multi-domain] Cd Length: 270 Bit Score: 45.15 E-value: 2.43e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  42 NFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTEMVLLiAMAFD 121
Cdd:cd15102   18 NLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANILLSGARTLRLSPAQWFLREGSMFVALSASVFSLL-AIAIE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 122 RYVAICKPLRYLTIMSPRMCLLIlVAAWIIGLIHSSaqlafvinLPFCGPNILDSFYcdiprlvklACTDT---YKLELM 198
Cdd:cd15102   97 RHLTMAKMKPYGASKTSRVLLLI-GACWLISLLLGG--------LPILGWNCLGALD---------ACSTVlplYSKHYV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 199 ITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSSKALST--LLAHITVVVL--------FFGPLIFFYVCPSPSTHV- 267
Cdd:cd15102  159 LFCVTIFAGILAAIVALYARIYCLVRASGRKATRASASPRSlaLLKTVLIVLLvfiacwgpLFILLLLDVACPVKTCPIl 238

                        250       260       270
                 ....*....|....*....|....*....|....
gi 168229222 268 ---DKFLAIfdAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15102  239 ykaDWFLAL--AVLNSALNPIIYTLRSRELRRAV 270

7tmA_GPR161

cd15214

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...

25-255

4.52e-05

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320342 [Multi-domain] Cd Length: 261 Bit Score: 44.16 E-value: 4.52e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLfyvssltGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15214    7 IIIAILICL-------GNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLY 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFcgpnilDSFycdiprl 184
Cdd:cd15214   80 LLISSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFGWSSLEF------DRF------- 146

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 168229222 185 vKLACTDTYKLELMITAN-SGFISLIAFFLLIISYVFLLttvqKQSSGCSSKALSTLLAHITVVVLFFGPLI 255
Cdd:cd15214  147 -KWMCVAAWHKEAGYTAFwQVWCALLPFVVMLVCYGFIF----RVARANQCKAFITILVVLGAFVTTWGPYM 213

7tmA_MC2R_ACTH_R

cd15350

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...

36-151

5.75e-05

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320472 [Multi-domain] Cd Length: 270 Bit Score: 44.00 E-value: 5.75e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  36 VSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGG--------CISQIFFSHAV 107
Cdd:cd15350   12 AVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADMGYLNRRGpfetklddIMDSLFCLSLL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 168229222 108 GgtEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWII 151
Cdd:cd15350   92 G--SIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTF 133

7tmA_tyramine_octopamine_R-like

cd15060

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...

41-297

5.77e-05

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320188 [Multi-domain] Cd Length: 260 Bit Score: 43.96 E-value: 5.77e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  41 GNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVisFGGCISQIFFSHAV-GGTEMVL-LIAM 118
Cdd:cd15060   17 GNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWL--FGIHLCQMWLTCDIlCCTASILnLCAI 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 119 AFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPfcgpnilDSFYCDIPrlvklaCTDTYKLELM 198
Cdd:cd15060   95 ALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIGWNDWP-------ENFTETTP------CTLTEEKGYV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 199 ITANSGFIsLIAFFLLIISYVFLLTTVQKQssgcsSKALSTLLAHITVVVLFFGPLIFFYV----CPS--PSTHVDKFLa 272
Cdd:cd15060  162 IYSSSGSF-FIPLLIMTIVYVKIFIATSKE-----RRAARTLGIIMGVFVVCWLPFFLMYVilpfCETcsPSAKVVNFI- 234

                        250       260
                 ....*....|....*....|....*
gi 168229222 273 IFDAVLTPFLNPIIYTLRNRDMKIA 297
Cdd:cd15060  235 TWLGYVNSALNPVIYTIFNLDFRRA 259

7tmA_mAChR_M1

cd17790

muscarinic acetylcholine receptor subtype M1, member of the class A family of ...

25-154

5.85e-05

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341356 [Multi-domain] Cd Length: 262 Bit Score: 43.80 E-value: 5.85e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd17790    1 VLIVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLI 154
Cdd:cd17790   81 YVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFV 130

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

25-157

7.50e-05

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 43.70 E-value: 7.50e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15318    1 LVIYLACAIGMLIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSS 157
Cdd:cd15318   81 TLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTS 133

7tmA_LPAR

cd15101

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...

30-296

8.41e-05

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 341325 [Multi-domain] Cd Length: 274 Bit Score: 43.27 E-value: 8.41e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  30 FTCLFYvssLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLiFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGG 109
Cdd:cd15101    9 TVCIFI---MLANLLVIAAIYKNRRFHFPIYYLLANLAAADF-FAGLAYFFLMFNTGPNTRRLTVSTWFLRQGLLDTSLT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 110 TEMVLLIAMAFDRYVAICKpLRYLTIMSPRMCLLILVAAWIIGLIHSSaqlafvinLPFCGPNILdsfyCDIPRLVKLA- 188
Cdd:cd15101   85 ASVANLLAIAVERHISVMR-MQLHSRLSNRRVVVLIVLVWTMAIVMGA--------IPSVGWNCL----CAIDACSNMAp 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 189 -CTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSSKALSTLLAHITVVVLFFGPlifFYVCPSPS--- 264
Cdd:cd15101  152 lYSRSYLVFWAISNLVTFLVMVVVYARIFVYVRRRTNRMSPHTSGSIRNRDTMMSLLKTVVIVLGA---FVVCWTPGlvv 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 168229222 265 -------------THVDKFLAIFdAVLTPFLNPIIYTLRNRDMKI 296
Cdd:cd15101  229 llldglccrqcnvLAVEKFFLLL-AEFNSAVNPIIYSYRDKEMSG 272

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

36-298

8.48e-05

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 43.57 E-value: 8.48e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  36 VSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTEMVLL 115
Cdd:cd15073   12 IISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 116 IAMAFDRYVAICKPLRYLTiMSPRMCLLILVAAWIIGLIHSSaqlafvinLPFCGpnildsFYCDIPRLVKLACTDT--- 192
Cdd:cd15073   92 TVVAVDRYLTICRPDLGRK-MTTNTYTVMILLAWTNAFFWAA--------MPLVG------WASYALDPTGATCTINwrk 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 193 ----YKLELMITANSGFIslIAFFLLIISYVFLLTTVQKQSSGCSSKALSTLLAH-ITVVVLFFGPLIFFYVCPSPSTHV 267
Cdd:cd15073  157 ndssFVSYTMSVIVVNFI--VPLAVMFYCYYNVSRFVKKVLASDCLESVNIDWTDqNDVTKMSVIMIVMFLVAWSPYSIV 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 168229222 268 DKFLAIFD--------AVLTP-------FLNPIIYTLRNRDMKIAI 298
Cdd:cd15073  235 CLWASFGEpkkippwmAIIPPlfaksstFYNPCIYVIANKKFRRAI 280

7tmA_alpha1D_AR

cd15327

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

30-297

9.45e-05

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320450 [Multi-domain] Cd Length: 261 Bit Score: 43.36 E-value: 9.45e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  30 FTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAP--------------KMICDLFRKQKVIsfg 95
Cdd:cd15327    6 FLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPfsatlevlgfwafgRVFCDIWAAVDVL--- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  96 gCISQIFFShavggtemvlLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLafvinLPFCGPNILD 175
Cdd:cd15327   83 -CCTASILS----------LCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPL-----LGWKEPPPPD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 176 SFYCDIPRLVKLACtdtyklelmitansgFISLIAFFL--LIISYVFLLTTVQKQSSGCSSKALSTLLAHITVVVLFFGP 253
Cdd:cd15327  147 ESICSITEEPGYAL---------------FSSLFSFYLplMVILVMYFRVYVVALKFSREKKAAKTLAIVVGVFILCWFP 211

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 168229222 254 liFFYVCP--------SPSTHVDK---FLAIFDAVltpfLNPIIYTLRNRDMKIA 297
Cdd:cd15327  212 --FFFVLPlgsffpalKPSEMVFKvifWLGYFNSC----VNPIIYPCSSKEFKRA 260

7tmA_mAChR_M3

cd15299

muscarinic acetylcholine receptor subtype M3, member of the class A family of ...

21-154

1.24e-04

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320426 [Multi-domain] Cd Length: 274 Bit Score: 43.01 E-value: 1.24e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  21 WEIqVFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQ 100
Cdd:cd15299    1 WQV-VLIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLW 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 168229222 101 IFFSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLI 154
Cdd:cd15299   80 LSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFV 133

7tm_GPCRs

cd14964

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...

28-291

1.28e-04

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410628 [Multi-domain] Cd Length: 267 Bit Score: 42.80 E-value: 1.28e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  28 FFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDliFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAV 107
Cdd:cd14964    2 TIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACD--LLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWY 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 108 GGTEMVLLIA--MAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFV-INLPFCGPNILDSFYCDIPRL 184
Cdd:cd14964   80 GANLASIWTTlvLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKgAIPRYNTLTGSCYLICTTIYL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITansgFISLIAFFLLIISYVFLLTTVQKQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVC---- 260
Cdd:cd14964  160 TWGFLLVSFLLPLVAF----LVIFSRIVLRLRRRVRAIRSAASLNTDKNLKATKSLLILVITFLLCWLPFSIVFILhalv 235

                        250       260       270
                 ....*....|....*....|....*....|..
gi 168229222 261 -PSPSTHVDKFLAIFDAVLTPFLNPIIYTLRN 291
Cdd:cd14964  236 aAGQGLNLLSILANLLAVLASTLNPFIYCLGN 267

7tmA_AstA_R_insect

cd15096

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...

28-154

1.38e-04

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320224 [Multi-domain] Cd Length: 284 Bit Score: 42.67 E-value: 1.38e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  28 FFFTCLFyVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAV 107
Cdd:cd15096    5 VIFGLIF-IVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVT 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 168229222 108 GGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLI 154
Cdd:cd15096   84 AYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILV 130

7tmA_GPR101

cd15215

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...

34-160

1.52e-04

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320343 [Multi-domain] Cd Length: 261 Bit Score: 42.52 E-value: 1.52e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  34 FYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTEMV 113
Cdd:cd15215    9 FLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGVN 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 168229222 114 LLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQL 160
Cdd:cd15215   89 TIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPL 135

7tmA_S1PR5_Edg8

cd15348

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...

27-298

1.67e-04

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320470 [Multi-domain] Cd Length: 277 Bit Score: 42.50 E-value: 1.67e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  27 IFFFTCLFYVSSltgNFIIVVTVTSDPYLHSPMYFLLANLSVIDLI--FCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15348    6 AFLAVCAFIVLE---NLIVLLALWRNKKFHSPMFYLLGSLTLSDLLagAAYAANILMSGANTLKLTPALWFLREGGVFIT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAvggTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLIlVAAWIIGLIHSSaqlafvinLPFCGPNILDSFycDIPRL 184
Cdd:cd15348   83 LT---ASVFSLLAIAIERHITMVRMKPYPGDKRGRMFLLI-GAAWLVSILLGV--------LPILGWNCLGNL--DACST 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 185 VKLACTDTYKLELMITANSGFISLIAFFLLIISYV-----FLLTTVQKQSSGCSSKALSTLLAHITVVVLFF----GPLI 255
Cdd:cd15348  149 VLPLYAKSYILFCITVFLAILAAIVVLYARIYRIVkansqRLGALPTRKGRARRSQKYLALLKTVTIVLGTFvacwLPLF 228

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 168229222 256 FFYV----CPSPSTHV----DKFLAIfdAVLTPFLNPIIYTLRNRDMKIAI 298
Cdd:cd15348  229 LLLLldvsCPAQACPVllkaDYFLGL--AMINSLLNPIIYTLTSRDMRRAI 277

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

25-165

1.75e-04

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 42.43 E-value: 1.75e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAP-KMI-----C----DLFRK-QKVIS 93
Cdd:cd15317    1 VIIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPfSMIrtvetCwyfgDLFCKfHTGLD 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 168229222  94 FGGCISQIFfshavggtemvLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVIN 165
Cdd:cd15317   81 LLLCTTSIF-----------HLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYTGAN 141

7tmA_5-HT1A_vertebrates

cd15330

serotonin receptor subtype 1A from vertebrates, member of the class A family of ...

38-156

2.02e-04

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320453 [Multi-domain] Cd Length: 260 Bit Score: 42.27 E-value: 2.02e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  38 SLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPkmICDLFRKQKVISFGGCISQIFFSHAV--GGTEMVLL 115
Cdd:cd15330   14 AIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLP--MAALYQVLNKWTLGQVTCDLFIALDVlcCTSSILHL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 168229222 116 IAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHS 156
Cdd:cd15330   92 CAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSIS 132

7tmA_Histamine_H2R

cd15051

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...

33-156

2.38e-04

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320179 [Multi-domain] Cd Length: 287 Bit Score: 41.93 E-value: 2.38e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  33 LFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAP-KMICDLFRKQkviSFGGCISQIFFSHAVG-GT 110
Cdd:cd15051    9 VIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPfSAIYELRGEW---PLGPVFCNIYISLDVMlCT 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 168229222 111 EMVL-LIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHS 156
Cdd:cd15051   86 ASILnLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVS 132

7tmA_GHSR-like

cd15928

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...

32-163

2.39e-04

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.

Pssm-ID: 320594 [Multi-domain] Cd Length: 288 Bit Score: 42.09 E-value: 2.39e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  32 CLFYVSsLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIaapkMICDLFR--KQKVISFGG--CISQIFFSHAV 107
Cdd:cd15928    9 VLMLVG-ASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLV----LPLDLYRlwRYRPWRFGDllCRLMYFFSETC 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 168229222 108 GGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFV 163
Cdd:cd15928   84 TYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLV 139

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

36-297

2.56e-04

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 41.86 E-value: 2.56e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  36 VSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMIcdLFRKQKVISFGGCIsqiFFSHAVggteMVL- 114
Cdd:cd14968   12 VLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAI--LISLGLPTNFHGCL---FMACLV----LVLt 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 115 ------LIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIiglihssaqLAFVINL-PFCGPNILDSFYCDIPR-LVK 186
Cdd:cd14968   83 qssifsLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWV---------LSFLVGLtPMFGWNNGAPLESGCGEgGIQ 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 187 LACTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQ-----SSGCSSKALSTLLAHI------TVVVLFFG--- 252
Cdd:cd14968  154 CLFEEVIPMDYMVYFNFFACVLVPLLIMLVIYLRIFRVIRKQlrqieSLLRSRRSRSTLQKEVkaakslAIILFLFAlcw 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 168229222 253 -PL----IFFYVCPSPSTHVDKFL-AIFDAVLTPFLNPIIYTLRNRDMKIA 297
Cdd:cd14968  234 lPLhiinCITLFCPECKVPKILTYiAILLSHANSAVNPIVYAYRIRKFRQT 284

7tmA_MC5R

cd15354

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...

36-295

2.76e-04

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320476 [Multi-domain] Cd Length: 270 Bit Score: 41.85 E-value: 2.76e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  36 VSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVID-LIFCSIAAPKMICDLFRKQKVI---SFGGCISQIFFSHAVGGT- 110
Cdd:cd15354   12 IISLLENILVILAIVKNKNLHSPMYFFVCSLAVADmLVSVSNAWETITIYLLNNRHLViedAFVRHIDNVFDSLICISVv 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 111 -EMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGlihSSAQLAFVInlpfcgpnildsFYCDIPRLVKLAC 189
Cdd:cd15354   92 aSMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFC---TGCGIIFIL------------YSESTYVIICLIT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 190 TDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSSKALSTLLAHITVV-VLFFGPLIFFYVCPSpSTHVD 268
Cdd:cd15354  157 MFFAMLFLMVSLYIHMFLLARTHVKRIAALPGYNSVRQRTSMKGAVTLTILLGIFIVCwAPFFLHLILMISCPQ-NLYCV 235

                        250       260       270
                 ....*....|....*....|....*....|..
gi 168229222 269 KFLAIFDAVL-----TPFLNPIIYTLRNRDMK 295
Cdd:cd15354  236 CFMSHFNMYLilimcNSVIDPLIYAFRSQEMR 267

7tmA_PR4-like

cd15392

neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...

25-154

2.80e-04

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.

Pssm-ID: 320514 [Multi-domain] Cd Length: 287 Bit Score: 41.96 E-value: 2.80e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKvISFGGCISQIF-F 103
Cdd:cd15392    1 VIIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLILQY-WPFGEFMCPVVnY 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 168229222 104 SHAVGgtemVL-----LIAMAFDRYVAICKPLRylTIMSPRMCLLILVAAWIIGLI 154
Cdd:cd15392   80 LQAVS----VFvsaftLVAISIDRYVAIMWPLR--PRMTKRQALLLIAVIWIFALA 129

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

25-287

2.91e-04

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 41.84 E-value: 2.91e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMIcdlfrkqkVISFGGCI-SQIFF 103
Cdd:cd15314    1 VLLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSM--------VRSVETCWyFGDLF 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 104 SHAVGGTEMVLLIA-------MAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIglihsSAQLAFVInlPFCGPNILDS 176
Cdd:cd15314   73 CKIHSSFDITLCTAsilnlcfISIDRYYAVCQPLLYRSKITVRVVLVMILISWSV-----SALVGFGI--IFLELNIKGI 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 177 FYCDIprlvklACTDtYKLELMITANSGFISLIAFFL--LIISYVFL--LTTVQKQ----------SSGCSS----KALS 238
Cdd:cd15314  146 YYNHV------ACEG-GCLVFFSKVSSVVGSVFSFYIpaVIMLCIYLkiFLVAQRQarsiqsartkSGASSSkmerKATK 218

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 168229222 239 TLLAHITVVVLFFGPLiFFYVCPSPSTHVDKFLAIFDAV-----LTPFLNPIIY 287
Cdd:cd15314  219 TLAIVMGVFLLCWTPF-FLCNIIDPFINYSIPPVLIEVLnwlgySNSTLNPFIY 271

7tmA_ET_R-like

cd14977

endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...

32-154

3.73e-04

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.

Pssm-ID: 320108 [Multi-domain] Cd Length: 292 Bit Score: 41.64 E-value: 3.73e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  32 CLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTE 111
Cdd:cd14977    8 LVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQVTSLGVT 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 168229222 112 MVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLI 154
Cdd:cd14977   88 VFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVL 130

7tmA_BNGR-A34-like

cd15000

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...

23-157

3.77e-04

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320131 [Multi-domain] Cd Length: 285 Bit Score: 41.26 E-value: 3.77e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  23 IQVFIFFFTCLFyvsSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIF 102
Cdd:cd15000    1 IKSSMFLPVVLF---GIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGF 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 168229222 103 FSHAVGGTEMVLLIAMAFDRYVAICKPLRylTIMSPRMCLLILVAAWIIGLIHSS 157
Cdd:cd15000   78 LEGSLLLASVLALCAVSYDRLTAIVLPSE--ARLTKRGAKIVIVITWIVGLLLAL 130

7tmA_SWS1_opsin

cd15076

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...

42-153

3.87e-04

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320204 [Multi-domain] Cd Length: 280 Bit Score: 41.34 E-value: 3.87e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  42 NFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTEMVLLIAMAFD 121
Cdd:cd15076   18 NAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVGSLAGLVTGWSLAFLAFE 97

                         90       100       110
                 ....*....|....*....|....*....|..
gi 168229222 122 RYVAICKPLRYLTiMSPRMCLLILVAAWIIGL 153
Cdd:cd15076   98 RYIVICKPFGNFR-FGSKHALGAVVATWIIGI 128

7tmA_5-HT2

cd15052

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...

29-297

4.92e-04

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320180 [Multi-domain] Cd Length: 262 Bit Score: 41.14 E-value: 4.92e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  29 FFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAP-KMICDLFRKQKVISFGGCISQIFFSHAV 107
Cdd:cd15052    5 LLLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLDVLF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 108 GGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIglihssaqlAFVINLPFCGPNILDsfycDIPRLVKL 187
Cdd:cd15052   85 CTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLI---------SIGISSPIPVLGIID----TTNVLNNG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 188 AC---TDTYKLELMITANsgFISLIAFFLLIISYVFLLTTVQKqssgcSSKALSTLLAhitVVVLFFGPLIFFYVCPSPS 264
Cdd:cd15052  152 TCvlfNPNFVIYGSIVAF--FIPLLIMVVTYALTIRLLSNEQK-----ASKVLGIVFA---VFVICWCPFFITNILTGLC 221

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 168229222 265 THVDKflAIFDAVLTPF---------LNPIIYTLRNRDMKIA 297
Cdd:cd15052  222 EECNC--RISPWLLSVFvwlgyvsstINPIIYTIFNKTFRRA 261

7tmA_GPR26_GPR78-like

cd15219

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...

29-162

6.22e-04

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320347 [Multi-domain] Cd Length: 264 Bit Score: 40.52 E-value: 6.22e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  29 FFTCLFYVSSLTGNFIIVVTVTSDPYL--HSPMYFLLaNLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHA 106
Cdd:cd15219    4 VLLVVVLVVSLLSNLLVLLCFLYSAELrkQVPGIFLL-NLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETF 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 168229222 107 VGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAF 162
Cdd:cd15219   83 LTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFL 138

7tmA_D1A_dopamine_R

cd15320

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...

30-156

6.79e-04

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320443 [Multi-domain] Cd Length: 319 Bit Score: 40.76 E-value: 6.79e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  30 FTCLFYVSSLTGNFIIVVTVTSDPYLHSPMY-FLLANLSVIDLIFCSIAAP-KMICDLFRKQKVISFggCISQIFFSHAV 107
Cdd:cd15320    7 FLSVLILSTLLGNTLVCAAVIRFRHLRSKVTnFFVISLAVSDLLVAVLVMPwKAVAEIAGFWPFGSF--CNIWVAFDIMC 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 168229222 108 GGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHS 156
Cdd:cd15320   85 STASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLIS 133

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

25-154

7.09e-04

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 40.74 E-value: 7.09e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAaPKMICDLFRKQkvISFGG--CISQIF 102
Cdd:cd14970    1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGL-PFLATSYLLGY--WPFGEvmCKIVLS 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 168229222 103 FSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLI 154
Cdd:cd14970   78 VDAYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLV 129

7tmA_CCK_R

cd15206

cholecystokinin receptors, member of the class A family of seven-transmembrane G ...

32-171

1.08e-03

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320334 [Multi-domain] Cd Length: 269 Bit Score: 40.07 E-value: 1.08e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  32 CLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTE 111
Cdd:cd15206    8 SVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSVSVS 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 112 MVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGP 171
Cdd:cd15206   88 TFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRP 147

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

25-297

1.20e-03

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 39.79 E-value: 1.20e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMIcdLFRKQKVISFGGCISQIFFS 104
Cdd:cd15063    1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSA--VNEVLDVWIFGHTWCQIWLA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVG--GTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIiglihssaqLAFVINLP-FCGPNILDSFYCDI 181
Cdd:cd15063   79 VDVWmcTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWV---------LSFVICFPpLVGWNDGKDGIMDY 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 182 PRLVKLACTDTyklelmITANSGFI---SLIAFFLLIISYVFLLTTVQKQSSgCSSKALSTLLAHITVVVLFFGPLIFFY 258
Cdd:cd15063  150 SGSSSLPCTCE------LTNGRGYViysALGSFYIPMLVMLFFYFRIYRAAR-METKAAKTVAIIVGCFIFCWLPFFTVY 222

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 168229222 259 V----CPSPSTHVDKFLAIFDAVLTPFLNPIIYTLRNRDMKIA 297
Cdd:cd15063  223 LvrafCEDCIPPLLFSVFFWLGYCNSALNPCIYALFSRDFRFA 265

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

114-166

1.24e-03

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 39.78 E-value: 1.24e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 168229222 114 LLIAMAFDRYVAICKPLRYLTIMSPRMCLLIlVAAWIIGLIHSSAQLaFVINL 166
Cdd:cd15386   90 MLIMMTVDRYIAVCHPLRTLQQPSRQAYLMI-GATWLLSCILSLPQV-FIFSL 140

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

25-156

1.26e-03

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 39.56 E-value: 1.26e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15329    1 VLIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHS 156
Cdd:cd15329   81 VLLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALIS 132

7tmA_NMU-R1

cd15358

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...

33-226

1.28e-03

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.

Pssm-ID: 320480 [Multi-domain] Cd Length: 305 Bit Score: 39.75 E-value: 1.28e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  33 LFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQK-VISFGGCISQIFFSHAVGGTE 111
Cdd:cd15358    9 LIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELYEMWSNYPfLLGAGGCYFKTLLFETVCFAS 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 112 MVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHS--SAQLAFVINLP-FCGPNILDSFYCdipRLVKLA 188
Cdd:cd15358   89 ILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSipNTSLHGIFQLTvPCRGPVPDSATC---MLVKPR 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 168229222 189 ctDTYKLELMITAnsgfisLIAFFL--LIISYVFLLTTVQ 226
Cdd:cd15358  166 --WMYNLIIQITT------LLFFFLpmGTISVLYLLIGLQ 197

7tmA_MC4R

cd15353

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...

36-295

1.33e-03

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320475 [Multi-domain] Cd Length: 269 Bit Score: 39.89 E-value: 1.33e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  36 VSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMIC-------DLFRKQKVISFGGCISQIFFSHAVG 108
Cdd:cd15353   12 IVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVitllngnDTDAQSFTVNIDNVIDSVICSSLLA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 109 gtEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSsaqlafvinlpfcgpnILDSFYCDipRLVKLA 188
Cdd:cd15353   92 --SICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSG----------------VLFIIYSD--SSVVII 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 189 CTDTYKLELMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSSKALSTLLAHITVVVL----FFGPLIFFYVCPSPS 264
Cdd:cd15353  152 CLISMFFTMLALMASLYVHMFLLARLHIKRIAVLPGTGPIRQGANMKGAITLTILLGVFVVcwapFFLHLIFYISCPRNP 231

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 168229222 265 THVdKFLAIFDAVL-----TPFLNPIIYTLRNRDMK 295
Cdd:cd15353  232 YCV-CFMSHFNMYLilimcNSVIDPLIYAFRSQELR 266

7tmA_MC3R

cd15352

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...

38-154

1.35e-03

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320474 [Multi-domain] Cd Length: 272 Bit Score: 39.87 E-value: 1.35e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  38 SLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFfsHAVGGTEMVL--- 114
Cdd:cd15352   14 SLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHM--DNVFDSMICIslv 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 168229222 115 -----LIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLI 154
Cdd:cd15352   92 asicnLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIV 136

7tmA_5-HT6

cd15054

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...

29-156

1.38e-03

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320182 [Multi-domain] Cd Length: 267 Bit Score: 39.79 E-value: 1.38e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  29 FFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVG 108
Cdd:cd15054    5 AFLCLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCC 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 168229222 109 GTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHS 156
Cdd:cd15054   85 SASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALAS 132

7tmA_Galanin_R-like

cd14971

galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...

29-161

1.59e-03

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320102 [Multi-domain] Cd Length: 281 Bit Score: 39.37 E-value: 1.59e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  29 FFTCLFYVSsLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVG 108
Cdd:cd14971    6 FFALIFLLG-LVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSM 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 168229222 109 GTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLA 161
Cdd:cd14971   85 HASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLA 137

7tmA_Chemokine_R

cd14984

classical and atypical chemokine receptors, member of the class A family of ...

25-253

1.67e-03

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.

Pssm-ID: 341319 [Multi-domain] Cd Length: 278 Bit Score: 39.51 E-value: 1.67e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIF-CSI---AAPKMICDLFRKQKVISFGGCISQ 100
Cdd:cd14984    1 VFLPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFvLTLpfwAVYAADGWVFGSFLCKLVSALYTI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 101 IFFShavggtEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYcd 180
Cdd:cd14984   81 NFYS------GILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSICSYDY-- 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 168229222 181 iPRLVKLACTDTYKLELMITansGFisLIAFFLLIISYVFLLTTVQKQSSGCSSKALSTLLAHITVVVLFFGP 253
Cdd:cd14984  153 -PEDTATTWKTLLRLLQNIL---GF--LLPLLVMLFCYSRIIRTLLRARNHKKHRALRVIFAVVVVFFLCWLP 219

7tmA_CCK-AR

cd15978

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...

29-168

1.70e-03

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320644 [Multi-domain] Cd Length: 278 Bit Score: 39.47 E-value: 1.70e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  29 FFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVG 108
Cdd:cd15978    5 LLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISV 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 109 GTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIiglihssaqLAFVINLPF 168
Cdd:cd15978   85 SVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWC---------LSFTIMLPY 135

7tmA_LPAR3_Edg7

cd15343

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...

23-294

1.89e-03

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320465 [Multi-domain] Cd Length: 274 Bit Score: 39.09 E-value: 1.89e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  23 IQVFIFFFTCLFYVSsltgNFIIVVTVTSDPYLHSPMYFLLANLSVIDLiFCSIAAPKMICDLFRKQKVISFGGCISQIF 102
Cdd:cd15343    3 VLCVGTFCCLFIFVS----NSLVIAAVVKNKRFHYPFYYLLANLAAADF-FAGIAYVFLMFNTGPVSKTLTVNRWFLRQG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 103 FSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVaAWIIGLihssaqlaFVINLPFCGPNILdsfyCDIP 182
Cdd:cd15343   78 LLDTSLSASLTNLLVIAVERHISIMRMKVHSNLTKRRVTLLIAL-VWAIAI--------FMGAVPTLGWNCI----CNIS 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 183 RLVKLACTDTYKLELMITANsgfiSLIAFFLLIISYVFLLTTVQKQS---SGCSSKALSTLLAHITVVVLFFGPLIFFYV 259
Cdd:cd15343  145 ACSSLAPIYSRSYLVFWSVS----NLVVFLIMVVVYLRIYVYVQRKTnvlSPHTSGSINRRRTPIKLMKTVMTVLGAFVI 220

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 168229222 260 CPSPS----------------THVDKFLAIFdAVLTPFLNPIIYTLRNRDM 294
Cdd:cd15343  221 CWTPGlvvllldglnctrcgvQHVKRWFLLL-ALLNSVMNPIIYSYKDEEM 270

7tmA_TACR

cd15390

neurokinin receptors (or tachykinin receptors), member of the class A family of ...

26-169

2.19e-03

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320512 [Multi-domain] Cd Length: 289 Bit Score: 39.20 E-value: 2.19e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  26 FIFFFTCLFYVSsLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSH 105
Cdd:cd15390    3 WSIVFVVMVLVA-IGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAI 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 168229222 106 AVGGTEMVLLIAMAFDRYVAICKPLRYLtiMSPRMCLLILVAAWIiglihssaqLAFVINLPFC 169
Cdd:cd15390   82 TTVAASVFTLMAISIDRYIAIVHPLRPR--LSRRTTKIAIAVIWL---------ASFLLALPQL 134

7tmA_mAChR

cd15049

muscarinic acetylcholine receptor subfamily, member of the class A family of ...

25-154

2.54e-03

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341322 [Multi-domain] Cd Length: 262 Bit Score: 38.84 E-value: 2.54e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPkmICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15049    1 VLICIATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMN--LYTVYLVMGYWPLGPLLCDLWLA 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 168229222 105 --HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLI 154
Cdd:cd15049   79 ldYVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFV 130

7tmA_mAChR_M2

cd15297

muscarinic acetylcholine receptor subtype M2, member of the class A family of ...

25-154

2.61e-03

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320424 [Multi-domain] Cd Length: 262 Bit Score: 38.79 E-value: 2.61e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIF--CSIaapkmicDLFRKQKVISF---GGCIS 99
Cdd:cd15297    1 VFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIgvFSM-------NLYTLYTVIGYwplGPVVC 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 168229222 100 QIFFS--HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLI 154
Cdd:cd15297   74 DLWLAldYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFI 130

7tmA_TRH-R

cd14995

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...

29-157

2.68e-03

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.

Pssm-ID: 320126 [Multi-domain] Cd Length: 269 Bit Score: 38.91 E-value: 2.68e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  29 FFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFG--GCISQIFFSHA 106
Cdd:cd14995    5 FLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGLPNEIESLLGPDSWIYGyaGCLLITYLQYL 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 168229222 107 VGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSS 157
Cdd:cd14995   85 GINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCS 135

7tmA_LPAR1_Edg2

cd15344

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...

39-296

2.87e-03

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 341348 [Multi-domain] Cd Length: 273 Bit Score: 38.85 E-value: 2.87e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  39 LTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLiFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTEMVLLIAM 118
Cdd:cd15344   15 MLANLLVMVAIYVNRRFHFPIYYLMANLAAADF-FAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 119 AFDRYVAICKpLRYLTIMSPRMCLLILVAAWIIGLIHSSaqlafvinLPFCGPNILdsfyCDIPRLVKLA--CTDTYKLE 196
Cdd:cd15344   94 AIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGA--------IPSVGWNCI----CDIENCSNMAplYSDSYLVF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 197 LMITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSSKALSTLLAHITVVVLFFGPLIFFY-----------VCPSPST 265
Cdd:cd15344  161 WAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWtpglvlllldvCCPQCDV 240

                        250       260       270
                 ....*....|....*....|....*....|.
gi 168229222 266 HVDKFLAIFDAVLTPFLNPIIYTLRNRDMKI 296
Cdd:cd15344  241 LAYEKFFLLLAEFNSAMNPIIYSYRDKEMSA 271

7tmA_mAChR_DM1-like

cd15301

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...

25-154

2.96e-03

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320428 [Multi-domain] Cd Length: 270 Bit Score: 38.65 E-value: 2.96e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15301    1 VLIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAID 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLI 154
Cdd:cd15301   81 YLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLL 130

7tmA_mAChR_M4

cd15298

muscarinic acetylcholine receptor subtype M4, member of the class A family of ...

25-154

3.04e-03

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341344 [Multi-domain] Cd Length: 262 Bit Score: 38.46 E-value: 3.04e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15298    1 VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLI 154
Cdd:cd15298   81 YVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFV 130

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

114-159

3.21e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 38.65 E-value: 3.21e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 168229222 114 LLIAMAFDRYVAICKPLRYLTIMSPRMCLLILvAAWIIGLIHSSAQ 159
Cdd:cd15385   90 MLVMMTADRYIAICHPLKTLQQPTKRSYLMIG-SAWALSFILSTPQ 134

7tmA_GHSR

cd15131

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...

31-179

3.95e-03

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.

Pssm-ID: 320259 [Multi-domain] Cd Length: 291 Bit Score: 38.33 E-value: 3.95e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  31 TCLF-YVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDL-IFCSiaapkMICDLFR--KQKVISFGGCISQIF--FS 104
Cdd:cd15131    6 TCVLlFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLlIFLC-----MPLDLYRlwQYRPWNFGDLLCKLFqfVS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCGPNILDSFYC 179
Cdd:cd15131   81 ESCTYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVLVGVEHENGTNPIDTNEC 155

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

115-163

4.04e-03

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 38.20 E-value: 4.04e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 168229222 115 LIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIglihsSAQLAFV 163
Cdd:cd15058   91 LCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIV-----SALVSFV 134

7tmA_PrRP_R

cd15394

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...

26-170

4.16e-03

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.

Pssm-ID: 320516 [Multi-domain] Cd Length: 286 Bit Score: 38.18 E-value: 4.16e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  26 FIFFFTCLFYVSsLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSH 105
Cdd:cd15394    3 IIPLYSLVVLVG-VVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRGWVFGRFMCYFVFLMQ 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 168229222 106 AVGGTEMVL-LIAMAFDRYVAICKPLRYLtiMSPRMCLLILVAAWIIGLIHSSAQLAFVINLPFCG 170
Cdd:cd15394   82 PVTVYVSVFtLTAIAVDRYYVTVYPLRRR--ISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEFKG 145

7tmA_Parietopsin

cd15085

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...

23-160

4.25e-03

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.

Pssm-ID: 320213 [Multi-domain] Cd Length: 280 Bit Score: 38.30 E-value: 4.25e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  23 IQVFIFFFTCLFyvsSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIF 102
Cdd:cd15085    2 ILSFLMFLNATF---SIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGF 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 168229222 103 FSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLiLVAAWIIGLIHSSAQL 160
Cdd:cd15085   79 AVNYFGIVSLWSLTLLAYERYNVVCKPMGGLKLSTKRGYQG-LLFIWLFCLFWAVAPL 135

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

41-153

4.37e-03

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 38.18 E-value: 4.37e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  41 GNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGTEMVLLIAMAF 120
Cdd:cd15050   17 LNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIFSLFILCI 96

                         90       100       110
                 ....*....|....*....|....*....|...
gi 168229222 121 DRYVAICKPLRYLTIMSPRMCLLILVAAWIIGL 153
Cdd:cd15050   97 DRYRSVQQPLKYLKYRTKTRASLMISGAWLLSF 129

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

27-162

4.89e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 37.85 E-value: 4.89e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  27 IFFFTCLFyvsSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVID-LIFCSIAAPKMICDLF-------RKQKVISFGGCI 98
Cdd:cd15351    6 LFLFLGLV---SLVENILVVVAIAKNRNLHSPMYYFICCLAVSDmLVSVSNLIETLFMLLLehgvlvcRAPMLQHMDNVI 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 168229222  99 SQIFFSHAVggTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHSSAQLAF 162
Cdd:cd15351   83 DTMICSSVV--SSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIVY 144

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

36-154

5.06e-03

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 37.99 E-value: 5.06e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  36 VSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMIcdLFRKQKVISFGGCISQIFFSHAVGGTEMVLL 115
Cdd:cd15068   12 VLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI--TISTGFCAACHGCLFIACFVLVLTQSSIFSL 89

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 168229222 116 IAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLI 154
Cdd:cd15068   90 LAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFA 128

7tmA_PAR

cd15162

protease-activated receptors, member of the class A family of seven-transmembrane G ...

33-265

5.50e-03

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.

Pssm-ID: 341328 [Multi-domain] Cd Length: 280 Bit Score: 37.81 E-value: 5.50e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  33 LFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGC--ISQIFFSHAVGgt 110
Cdd:cd15162    9 LVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCrlVTVAFYGNMYC-- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 111 EMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIiglihssaqLAFVINLPFcgpNILDSFYcDIPRLVKLACT 190
Cdd:cd15162   87 SILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWL---------LALLVTLPL---YLVKQTI-FLPALDITTCH 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 191 DTYKLELM-------ITANSGFISLIAFFLLIISYVFLLTTVQKQSSGCSSK----ALSTLLAHITVVVLFFGP----LI 255
Cdd:cd15162  154 DVLPEQLLvgdwfyyFLSLAIVGFLIPFILTASCYVATIRTLAALEDENSEKkkkrAIKLAATVLAIFIICFAPsnllLL 233

                        250
                 ....*....|
gi 168229222 256 FFYVCPSPST 265
Cdd:cd15162  234 AHYSLISSSG 243

7tmA_TACR-like

cd15202

tachykinin receptors and related receptors, member of the class A family of ...

25-131

5.64e-03

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320330 [Multi-domain] Cd Length: 288 Bit Score: 37.87 E-value: 5.64e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFS 104
Cdd:cd15202    1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQ 80

                         90       100
                 ....*....|....*....|....*..
gi 168229222 105 HAVGGTEMVLLIAMAFDRYVAICKPLR 131
Cdd:cd15202   81 YCSVHVSAYTLTAIAVDRYQAIMHPLK 107

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

25-156

6.01e-03

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 37.72 E-value: 6.01e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  25 VFIFFFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAP-KMI-----C----DLFRK-QKVIS 93
Cdd:cd15312    1 VAMYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPySMVrsvesCwyfgDLFCKiHSSLD 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 168229222  94 FGGCISQIFFshavggtemvlLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHS 156
Cdd:cd15312   81 MMLSTTSIFH-----------LCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFA 132

7tmA_D1-like_dopamine_R

cd15057

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...

30-156

6.06e-03

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320185 [Multi-domain] Cd Length: 299 Bit Score: 37.79 E-value: 6.06e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  30 FTCLFYVSSLTGNFIIVVTVTSDPYLHSPMY-FLLANLSVIDLIFCSIAAPKMICDLFrkQKVISFGG-CISQIFFSHAV 107
Cdd:cd15057    6 ILYLLVLLTLLGNALVIAAVLRFRHLRSKVTnYFIVSLAVSDLLVAILVMPWAAVNEV--AGYWPFGSfCDVWVSFDIMC 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 168229222 108 GGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIHS 156
Cdd:cd15057   84 STASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALIS 132

7tmA_GPR151

cd15002

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...

62-162

6.39e-03

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320133 [Multi-domain] Cd Length: 280 Bit Score: 37.77 E-value: 6.39e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  62 LLANLSVIDLIFCSIAAPkmicdlFR----KQKVISFGG--CISQIFFSHAVGGTEMVLLIAMAFDRYVAICKPLRYLTI 135
Cdd:cd15002   39 LILNLSAADLLLLLFSVP------FRaaaySKGSWPLGWfvCKTADWFGHACMAAKSFTIAVLAKACYMYVVNPTKQVTI 112

                         90       100
                 ....*....|....*....|....*..
gi 168229222 136 mSPRMCLLILVAAWIIGLIHSSAQLAF 162
Cdd:cd15002  113 -KQRRITAVVASIWVPACLLPLPQWLF 138

7tmA_5-HT2B

cd15306

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...

29-300

6.88e-03

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341347 [Multi-domain] Cd Length: 277 Bit Score: 37.50 E-value: 6.88e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  29 FFTCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAP-KMICDLFRKQKVISFGGCISQIFFSHAV 107
Cdd:cd15306    5 LLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPiALLTILFEAMWPLPLVLCPIWLFLDVLF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 108 GGTEMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIglihsSAQLAFVInlPFCGPNILDSFYCDIPRLVKl 187
Cdd:cd15306   85 STASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLI-----SIGIAIPV--PIKGIETDVDNPNNITCVLT- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 188 acTDTYKlELMItansgFISLIAFF----LLIISYVFLLTTVQKQSSGCSSKALSTLLAHITVVVLFFGPLIFFYVC--- 260
Cdd:cd15306  157 --KERFG-DFIL-----FGSLAAFFtplaIMIVTYFLTIHALRKQTITNEQRASKVLGIVFFLFLLMWCPFFITNITsvl 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 168229222 261 --PSPSTHVDKFLAIFDAV--LTPFLNPIIYTLRNRDMKIAIRK 300
Cdd:cd15306  229 cdSCNQTTLQMLMEIFVWIgyVSSGVNPLVYTLFNKTFRDAFGR 272

7tmA_5-HT1B_1D

cd15333

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...

33-153

7.52e-03

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320455 [Multi-domain] Cd Length: 265 Bit Score: 37.47 E-value: 7.52e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  33 LFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPkmICDLFRKQKVISFGGCISQIFFSHAVG--GT 110
Cdd:cd15333   13 LITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMP--ISIVYTVTGTWTLGQVVCDIWLSSDITccTA 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 168229222 111 EMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGL 153
Cdd:cd15333   91 SILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISI 133

7tmA_tyramine_R-like

cd15061

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

115-293

8.49e-03

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320189 [Multi-domain] Cd Length: 256 Bit Score: 37.34 E-value: 8.49e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 115 LIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLIhssaqlafVINLPFCGPnildsfYCDIPRLVKlACTDTYK 194
Cdd:cd15061   90 LCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLL--------ITSPPLVGP------SWHGRRGLG-SCYYTYD 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222 195 LELMItansgFISLIAFF--LLIISYVFLLTTVQKQSsgcSSKALSTLLAHITVVVLFFGPLIFFYV----CPSPSTHVD 268
Cdd:cd15061  155 KGYRI-----YSSMGSFFlpLLLMLFVYLRIFRVIAK---ERKTAKTLAIVVGCFIVCWLPFFIMYLiepfCDCQFSEAL 226

                        170       180
                 ....*....|....*....|....*
gi 168229222 269 KFLAIFDAVLTPFLNPIIYTLRNRD 293
Cdd:cd15061  227 STAFTWLGYFNSVINPFIYAFYNKD 251

7tmA_alpha2_AR

cd15059

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...

41-167

9.06e-03

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320187 [Multi-domain] Cd Length: 261 Bit Score: 36.94 E-value: 9.06e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  41 GNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAP--------------KMICDLFRKQKVISfggCISQIFFsha 106
Cdd:cd15059   17 GNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPfslvnelmgywyfgSVWCEIWLALDVLF---CTASIVN--- 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 168229222 107 vggtemvlLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIglihssaqlAFVINLP 167
Cdd:cd15059   91 --------LCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWII---------SAVISLP 134

7tmA_ET-BR

cd15976

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...

31-154

9.32e-03

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.

Pssm-ID: 320642 [Multi-domain] Cd Length: 296 Bit Score: 37.14 E-value: 9.32e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 168229222  31 TCLFYVSSLTGNFIIVVTVTSDPYLHSPMYFLLANLSVIDLIFCSIAAPKMICDLFRKQKVISFGGCISQIFFSHAVGGT 110
Cdd:cd15976    7 SCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGI 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 168229222 111 EMVLLIAMAFDRYVAICKPLRYLTIMSPRMCLLILVAAWIIGLI 154
Cdd:cd15976   87 TVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSII 130

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01