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Conserved domains on  [gi|1679807465|ref|XP_029335584|]
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tenascin-R isoform X2 [Mus caroli]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 975-1184 1.26e-120

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


:

Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 371.22  E-value: 1.26e-120
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465   975 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1054
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGS-SRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  1055 NIHRITAQGRYELRVDMRD-GQEAVFAYYDKFAVEDSRSLYKLRIGSYNGTAGD-SLSYHQGRPFSTEDRDNDVAVTNCA 1132
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1679807465  1133 MSYKGAWWYKNCHRTNLNGKYG-ESRHSQGINWYHWKGHEFSIPFVEMKMRPY 1184
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
407-597 1.20e-17

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 88.14  E-value: 1.20e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  407 PGSRYEVSISAVRGINESDASS----TQFTTEIDAPKNLRVGSRTATSLDLEWD-NSEAEAQEYKVVYSTLAGEQYHEvl 481
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTK-- 278

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  482 vpkgIGPTTKTTLTD--LVPGTEYGVGISAVMN----SKQSIPATMNARTEL-DSPRDLMVTASSETSISLIWTKASGP- 553
Cdd:COG3401    279 ----VATVTTTSYTDtgLTNGTTYYYRVTAVDAagneSAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSDAd 354

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1679807465  554 IDHYRIT-FTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITA 597
Cdd:COG3401    355 VTGYNVYrSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399
fn3 pfam00041
Fibronectin type III domain;
706-785 1.91e-14

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.75  E-value: 1.91e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  706 DPPKNITIGNVTKDSLTVSWSPPV---APFDYYRVSYRPTQVGRLDSSV-VPNTVTEFTITRLYPATEYEISLNSVRGRE 781
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1679807465  782 ESER 785
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
169-239 7.98e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 7.98e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1679807465  169 PPEDLRVAGISDRSIELEW----DGPMAVTEYVISYQPTALGGLQLQQRVPGDWSGVTITELEPGLTYNISVYAV 239
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
257-336 1.79e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 1.79e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  257 STPQGLQFKTITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGVIAQ-LPSDVTSFNQTGLKPGEEYIVNVVALKEQA 332
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1679807465  333 RSPP 336
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 883-968 6.04e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 6.04e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  883 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSRKELI--VDAEDTWIRLEGLSENTDYTVLLQAAQEAT 957
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1679807465  958 RS-SLTSTVFTT 968
Cdd:cd00063     82 ESpPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
617-696 8.97e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 8.97e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  617 PISHLHFSHVTSSSVNITWSdPSPPADRLILNYS----PRDEEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTV 692
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWT-PPPDGNGPITGYEveyrPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1679807465  693 TSEP 696
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
348-427 2.33e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 2.33e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  348 PTQILVRDVSDTVAFVEWTPPR---AKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGINES 424
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 1679807465  425 DAS 427
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
795-867 3.58e-07

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 3.58e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  795 DSPMDLIATNITPTEALLQWKAPM---GEVENYVIVLTHfaiAGE-----TILVDGVSEEFQLVDLLPSTHYTVTMYATS 866
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRP---KNSgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   .
gi 1679807465  867 G 867
Cdd:pfam00041   78 G 78
 
Name Accession Description Interval E-value
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 975-1184 1.26e-120

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 371.22  E-value: 1.26e-120
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465   975 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1054
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGS-SRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  1055 NIHRITAQGRYELRVDMRD-GQEAVFAYYDKFAVEDSRSLYKLRIGSYNGTAGD-SLSYHQGRPFSTEDRDNDVAVTNCA 1132
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1679807465  1133 MSYKGAWWYKNCHRTNLNGKYG-ESRHSQGINWYHWKGHEFSIPFVEMKMRPY 1184
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 975-1183 8.51e-120

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 368.88  E-value: 8.51e-120
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  975 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1054
Cdd:cd00087      2 LPRDCSEVLQRGGRTSGVYTIQPPGS-NEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465 1055 NIHRITAQGRYELRVDMRDG-QEAVFAYYDKFAVEDSRSLYKLRIGSYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAM 1133
Cdd:cd00087     81 KIHLLTSQGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCAE 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1679807465 1134 SYKGAWWYKNCHRTNLNGKYGESRH----SQGINWYHWKGHEFSIPFVEMKMRP 1183
Cdd:cd00087    161 SYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRP 214
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
976-1184 4.93e-99

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 313.69  E-value: 4.93e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  976 PQDCAQHLMNGDTLSGVYTIFLNGELShKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLE-DEFWLGLD 1054
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGATK-PFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGND 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465 1055 NIHRITAQGRYELRVDMRDGQ-EAVFAYYDKFAVEDSRSLYKLRIGSYNGTAGD-------SLSYHQGRPFSTEDRDNDV 1126
Cdd:pfam00147   81 KIHLLTKQGPYVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDNDS 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1679807465 1127 AVTNCAMSYKGAWWYKNCHRTNLNGKY--GESRHSQ-GINWYHWKGHEFSIPFVEMKMRPY 1184
Cdd:pfam00147  161 PDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
407-597 1.20e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 88.14  E-value: 1.20e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  407 PGSRYEVSISAVRGINESDASS----TQFTTEIDAPKNLRVGSRTATSLDLEWD-NSEAEAQEYKVVYSTLAGEQYHEvl 481
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTK-- 278

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  482 vpkgIGPTTKTTLTD--LVPGTEYGVGISAVMN----SKQSIPATMNARTEL-DSPRDLMVTASSETSISLIWTKASGP- 553
Cdd:COG3401    279 ----VATVTTTSYTDtgLTNGTTYYYRVTAVDAagneSAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSDAd 354

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1679807465  554 IDHYRIT-FTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITA 597
Cdd:COG3401    355 VTGYNVYrSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399
fn3 pfam00041
Fibronectin type III domain;
528-607 1.45e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.14  E-value: 1.45e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  528 DSPRDLMVTASSETSISLIWTKA---SGPIDHYRITFTPSSGISS--EVTVPRDRTSYTLTDLEPGAEYIISITAERGRQ 602
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1679807465  603 QSLES 607
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
706-785 1.91e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.75  E-value: 1.91e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  706 DPPKNITIGNVTKDSLTVSWSPPV---APFDYYRVSYRPTQVGRLDSSV-VPNTVTEFTITRLYPATEYEISLNSVRGRE 781
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1679807465  782 ESER 785
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 706-784 1.32e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 1.32e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  706 DPPKNITIGNVTKDSLTVSWSPPV---APFDYYRVSYRPTQVGR-LDSSVVPNTVTEFTITRLYPATEYEISLNSVRGRE 781
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ...
gi 1679807465  782 ESE 784
Cdd:cd00063     82 ESP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 528-613 6.02e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.60  E-value: 6.02e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  528 DSPRDLMVTASSETSISLIWTKAS---GPIDHYRITFTP-SSGISSEVTVPR-DRTSYTLTDLEPGAEYIISITAERGRQ 602
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREkGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1679807465  603 QSLESTVDAFT 613
Cdd:cd00063     82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 528-604 1.19e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.56  E-value: 1.19e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465   528 DSPRDLMVTASSETSISLIWTKAS-----GPIDHYRITFTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITAERGRQ 602
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1679807465   603 QS 604
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
169-239 7.98e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 7.98e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1679807465  169 PPEDLRVAGISDRSIELEW----DGPMAVTEYVISYQPTALGGLQLQQRVPGDWSGVTITELEPGLTYNISVYAV 239
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 169-254 1.57e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  169 PPEDLRVAGISDRSIELEWDGP----MAVTEYVISYQPTALGGLQLQQRVPGDWSGVTITELEPGLTYNISVYAVISNIL 244
Cdd:cd00063      3 PPTNLRVTDVTSTSVTLSWTPPeddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82

                           90
                   ....*....|
gi 1679807465  245 SLPITAKVAT 254
Cdd:cd00063     83 SPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
257-336 1.79e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 1.79e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  257 STPQGLQFKTITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGVIAQ-LPSDVTSFNQTGLKPGEEYIVNVVALKEQA 332
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1679807465  333 RSPP 336
Cdd:pfam00041   81 EGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 706-783 3.92e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.32  E-value: 3.92e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465   706 DPPKNITIGNVTKDSLTVSWSPP-----VAPFDYYRVSYRPTQVGRLDSSVVPNTvTEFTITRLYPATEYEISLNSVRGR 780
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSS-TSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 1679807465   781 EES 783
Cdd:smart00060   81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 883-968 6.04e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 6.04e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  883 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSRKELI--VDAEDTWIRLEGLSENTDYTVLLQAAQEAT 957
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1679807465  958 RS-SLTSTVFTT 968
Cdd:cd00063     82 ESpPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
617-696 8.97e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 8.97e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  617 PISHLHFSHVTSSSVNITWSdPSPPADRLILNYS----PRDEEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTV 692
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWT-PPPDGNGPITGYEveyrPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1679807465  693 TSEP 696
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
348-427 2.33e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 2.33e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  348 PTQILVRDVSDTVAFVEWTPPR---AKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGINES 424
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 1679807465  425 DAS 427
Cdd:pfam00041   83 PPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 883-959 2.46e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.01  E-value: 2.46e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465   883 DPPDNLTASEVTRQSALISWQPPRAA-----IENYVLTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQAAQEAT 957
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1679807465   958 RS 959
Cdd:smart00060   82 EG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
168-367 1.78e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 61.94  E-value: 1.78e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  168 APPEDLRVAGISDRSIELEWDGP--MAVTEYVISYQPTALGGLQLQQRVPGdwSGVTITELEPGLTYNISVYAVISN--- 242
Cdd:COG3401    234 SAPTGLTATADTPGSVTLSWDPVteSDATGYRVYRSNSGDGPFTKVATVTT--TSYTDTGLTNGTTYYYRVTAVDAAgne 311

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  243 -ILSLPITAKVATHL-STPQGLQFKTITETTVEVQWEPfsfSFDGWEISFI--PKNNEGGVIAQL--PSDVTSFNQTGLK 316
Cdd:COG3401    312 sAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTA---SSDADVTGYNvyRSTSGGGTYTKIaeTVTTTSYTDTGLT 388

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1679807465  317 PGEEYIVNVVAL----KEQARSPPISASVSTVIDGPTQILVRDVSDTVAFVEWTP 367
Cdd:COG3401    389 PGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATA 443
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 979-1018 2.73e-09

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 53.72  E-value: 2.73e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1679807465  979 CAQ-HLMNGDTLSGVYTIFLNGELSHK-LQVYCDMTTDGGGW 1018
Cdd:NF040941     2 CWEiLQAGPSAPSGVYWIDPDGMGGLApFQVYCDMTTDGGGW 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 257-344 5.85e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 5.85e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  257 STPQGLQFKTITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGV-IAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQA 332
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1679807465  333 RSPPISASVSTV 344
Cdd:cd00063     82 ESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
883-952 1.06e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.06e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1679807465  883 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSR--KELIVDAEDTWIRLEGLSENTDYTVLLQA 952
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 169-239 2.70e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 2.70e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1679807465   169 PPEDLRVAGISDRSIELEWDGP--MAVTEYVISYQPTALGGLQLQQRVPGDWSG--VTITELEPGLTYNISVYAV 239
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGSEWKEVNVTPSStsYTLTGLKPGTEYEFRVRAV 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 617-703 3.04e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 3.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  617 PISHLHFSHVTSSSVNITWSDPSPPADRL---ILNYSPRDEEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTVT 693
Cdd:cd00063      3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPItgyVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82

                           90
                   ....*....|.
gi 1679807465  694 SEPI-VGSITT 703
Cdd:cd00063     83 SPPSeSVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 346-433 3.56e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 3.56e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  346 DGPTQILVRDVSDTVAFVEWTPPRAKVDFIL---LKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGIN 422
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgyvVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1679807465  423 ESDAS-STQFTT 433
Cdd:cd00063     82 ESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 617-688 5.19e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 5.19e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1679807465   617 PISHLHFSHVTSSSVNITWSDPSPPADRL-ILNYSPRDEEEDM--LEVLLDATKRHAVLMGLQPATEYIVNLVAV 688
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
fn3 pfam00041
Fibronectin type III domain;
795-867 3.58e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 3.58e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  795 DSPMDLIATNITPTEALLQWKAPM---GEVENYVIVLTHfaiAGE-----TILVDGVSEEFQLVDLLPSTHYTVTMYATS 866
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRP---KNSgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   .
gi 1679807465  867 G 867
Cdd:pfam00041   78 G 78
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 257-327 2.01e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 2.01e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1679807465   257 STPQGLQFKTITETTVEVQWEPFSFSFDGW-EISFIPKNNEGG---VIAQLPSDVTSFNQTGLKPGEEYIVNVVA 327
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 346-424 6.96e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 6.96e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465   346 DGPTQILVRDVSDTVAFVEWTPP-RAKVDFILLKYGLVGGEGGKTTFRL--QPPLSQYSVQALRPGSRYEVSISAVRGIN 422
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1679807465   423 ES 424
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 795-867 1.24e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 1.24e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1679807465   795 DSPMDLIATNITPTEALLQWKAP-----MGEVENYVIVLTHFAIAGETILVDGVSEEFQLVDLLPSTHYTVTMYATSG 867
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 795-876 5.42e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 5.42e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  795 DSPMDLIATNITPTEALLQWKAP---MGEVENYVIVLT-HFAIAGETILVDGVSE-EFQLVDLLPSTHYTVTMYA----- 864
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYReKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAvnggg 81

                           90
                   ....*....|..
gi 1679807465  865 TSGPLMSGTIAT 876
Cdd:cd00063     82 ESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 975-1184 1.26e-120

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 371.22  E-value: 1.26e-120
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465   975 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1054
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGS-SRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  1055 NIHRITAQGRYELRVDMRD-GQEAVFAYYDKFAVEDSRSLYKLRIGSYNGTAGD-SLSYHQGRPFSTEDRDNDVAVTNCA 1132
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1679807465  1133 MSYKGAWWYKNCHRTNLNGKYG-ESRHSQGINWYHWKGHEFSIPFVEMKMRPY 1184
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 975-1183 8.51e-120

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 368.88  E-value: 8.51e-120
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  975 HPQDCAQHLMNGDTLSGVYTIFLNGElSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLD 1054
Cdd:cd00087      2 LPRDCSEVLQRGGRTSGVYTIQPPGS-NEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465 1055 NIHRITAQGRYELRVDMRDG-QEAVFAYYDKFAVEDSRSLYKLRIGSYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAM 1133
Cdd:cd00087     81 KIHLLTSQGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCAE 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1679807465 1134 SYKGAWWYKNCHRTNLNGKYGESRH----SQGINWYHWKGHEFSIPFVEMKMRP 1183
Cdd:cd00087    161 SYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRP 214
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
976-1184 4.93e-99

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 313.69  E-value: 4.93e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  976 PQDCAQHLMNGDTLSGVYTIFLNGELShKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLE-DEFWLGLD 1054
Cdd:pfam00147    2 GRDCSDVYNKGAKTSGLYTIRPDGATK-PFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSpGEFWLGND 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465 1055 NIHRITAQGRYELRVDMRDGQ-EAVFAYYDKFAVEDSRSLYKLRIGSYNGTAGD-------SLSYHQGRPFSTEDRDNDV 1126
Cdd:pfam00147   81 KIHLLTKQGPYVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDNDS 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1679807465 1127 AVTNCAMSYKGAWWYKNCHRTNLNGKY--GESRHSQ-GINWYHWKGHEFSIPFVEMKMRPY 1184
Cdd:pfam00147  161 PDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
407-597 1.20e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 88.14  E-value: 1.20e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  407 PGSRYEVSISAVRGINESDASS----TQFTTEIDAPKNLRVGSRTATSLDLEWD-NSEAEAQEYKVVYSTLAGEQYHEvl 481
Cdd:COG3401    201 PGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDATGYRVYRSNSGDGPFTK-- 278

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  482 vpkgIGPTTKTTLTD--LVPGTEYGVGISAVMN----SKQSIPATMNARTEL-DSPRDLMVTASSETSISLIWTKASGP- 553
Cdd:COG3401    279 ----VATVTTTSYTDtgLTNGTTYYYRVTAVDAagneSAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTASSDAd 354

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1679807465  554 IDHYRIT-FTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITA 597
Cdd:COG3401    355 VTGYNVYrSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTA 399
fn3 pfam00041
Fibronectin type III domain;
528-607 1.45e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.14  E-value: 1.45e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  528 DSPRDLMVTASSETSISLIWTKA---SGPIDHYRITFTPSSGISS--EVTVPRDRTSYTLTDLEPGAEYIISITAERGRQ 602
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1679807465  603 QSLES 607
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
706-785 1.91e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.75  E-value: 1.91e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  706 DPPKNITIGNVTKDSLTVSWSPPV---APFDYYRVSYRPTQVGRLDSSV-VPNTVTEFTITRLYPATEYEISLNSVRGRE 781
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1679807465  782 ESER 785
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 706-784 1.32e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 1.32e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  706 DPPKNITIGNVTKDSLTVSWSPPV---APFDYYRVSYRPTQVGR-LDSSVVPNTVTEFTITRLYPATEYEISLNSVRGRE 781
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ...
gi 1679807465  782 ESE 784
Cdd:cd00063     82 ESP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 528-613 6.02e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.60  E-value: 6.02e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  528 DSPRDLMVTASSETSISLIWTKAS---GPIDHYRITFTP-SSGISSEVTVPR-DRTSYTLTDLEPGAEYIISITAERGRQ 602
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREkGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1679807465  603 QSLESTVDAFT 613
Cdd:cd00063     82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 528-604 1.19e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.56  E-value: 1.19e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465   528 DSPRDLMVTASSETSISLIWTKAS-----GPIDHYRITFTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITAERGRQ 602
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1679807465   603 QS 604
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
169-239 7.98e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 7.98e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1679807465  169 PPEDLRVAGISDRSIELEW----DGPMAVTEYVISYQPTALGGLQLQQRVPGDWSGVTITELEPGLTYNISVYAV 239
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 169-254 1.57e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  169 PPEDLRVAGISDRSIELEWDGP----MAVTEYVISYQPTALGGLQLQQRVPGDWSGVTITELEPGLTYNISVYAVISNIL 244
Cdd:cd00063      3 PPTNLRVTDVTSTSVTLSWTPPeddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82

                           90
                   ....*....|
gi 1679807465  245 SLPITAKVAT 254
Cdd:cd00063     83 SPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
257-336 1.79e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.28  E-value: 1.79e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  257 STPQGLQFKTITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGVIAQ-LPSDVTSFNQTGLKPGEEYIVNVVALKEQA 332
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEItVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1679807465  333 RSPP 336
Cdd:pfam00041   81 EGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 706-783 3.92e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.32  E-value: 3.92e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465   706 DPPKNITIGNVTKDSLTVSWSPP-----VAPFDYYRVSYRPTQVGRLDSSVVPNTvTEFTITRLYPATEYEISLNSVRGR 780
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSS-TSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 1679807465   781 EES 783
Cdd:smart00060   81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 883-968 6.04e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 6.04e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  883 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSRKELI--VDAEDTWIRLEGLSENTDYTVLLQAAQEAT 957
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1679807465  958 RS-SLTSTVFTT 968
Cdd:cd00063     82 ESpPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
617-696 8.97e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.35  E-value: 8.97e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  617 PISHLHFSHVTSSSVNITWSdPSPPADRLILNYS----PRDEEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTV 692
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWT-PPPDGNGPITGYEveyrPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1679807465  693 TSEP 696
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
348-427 2.33e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 2.33e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  348 PTQILVRDVSDTVAFVEWTPPR---AKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGINES 424
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 1679807465  425 DAS 427
Cdd:pfam00041   83 PPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 883-959 2.46e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.01  E-value: 2.46e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465   883 DPPDNLTASEVTRQSALISWQPPRAA-----IENYVLTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQAAQEAT 957
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1679807465   958 RS 959
Cdd:smart00060   82 EG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
168-367 1.78e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 61.94  E-value: 1.78e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  168 APPEDLRVAGISDRSIELEWDGP--MAVTEYVISYQPTALGGLQLQQRVPGdwSGVTITELEPGLTYNISVYAVISN--- 242
Cdd:COG3401    234 SAPTGLTATADTPGSVTLSWDPVteSDATGYRVYRSNSGDGPFTKVATVTT--TSYTDTGLTNGTTYYYRVTAVDAAgne 311

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  243 -ILSLPITAKVATHL-STPQGLQFKTITETTVEVQWEPfsfSFDGWEISFI--PKNNEGGVIAQL--PSDVTSFNQTGLK 316
Cdd:COG3401    312 sAPSNVVSVTTDLTPpAAPSGLTATAVGSSSITLSWTA---SSDADVTGYNvyRSTSGGGTYTKIaeTVTTTSYTDTGLT 388

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1679807465  317 PGEEYIVNVVAL----KEQARSPPISASVSTVIDGPTQILVRDVSDTVAFVEWTP 367
Cdd:COG3401    389 PGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATA 443
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 436-520 2.16e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.58  E-value: 2.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  436 DAPKNLRVGSRTATSLDLEWD---NSEAEAQEYKVVYSTLAGEQYHEVlvPKGIGPTTKTTLTDLVPGTEYGVGISAVMN 512
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTppeDDGGPITGYVVEYREKGSGDWKEV--EVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79


                   ....*...
gi 1679807465  513 SKQSIPAT 520
Cdd:cd00063     80 GGESPPSE 87
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 979-1018 2.73e-09

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 53.72  E-value: 2.73e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1679807465  979 CAQ-HLMNGDTLSGVYTIFLNGELSHK-LQVYCDMTTDGGGW 1018
Cdd:NF040941     2 CWEiLQAGPSAPSGVYWIDPDGMGGLApFQVYCDMTTDGGGW 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 257-344 5.85e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.42  E-value: 5.85e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  257 STPQGLQFKTITETTVEVQWEPFSFS---FDGWEISFIPKNNEGGV-IAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQA 332
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKeVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1679807465  333 RSPPISASVSTV 344
Cdd:cd00063     82 ESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
883-952 1.06e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.06e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1679807465  883 DPPDNLTASEVTRQSALISWQPPR---AAIENYVLTYKSTDGSR--KELIVDAEDTWIRLEGLSENTDYTVLLQA 952
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 169-239 2.70e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 2.70e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1679807465   169 PPEDLRVAGISDRSIELEWDGP--MAVTEYVISYQPTALGGLQLQQRVPGDWSG--VTITELEPGLTYNISVYAV 239
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPpdDGITGYIVGYRVEYREEGSEWKEVNVTPSStsYTLTGLKPGTEYEFRVRAV 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 617-703 3.04e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 3.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  617 PISHLHFSHVTSSSVNITWSDPSPPADRL---ILNYSPRDEEEDMLEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTVT 693
Cdd:cd00063      3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPItgyVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82

                           90
                   ....*....|.
gi 1679807465  694 SEPI-VGSITT 703
Cdd:cd00063     83 SPPSeSVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 346-433 3.56e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.11  E-value: 3.56e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  346 DGPTQILVRDVSDTVAFVEWTPPRAKVDFIL---LKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGIN 422
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITgyvVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1679807465  423 ESDAS-STQFTT 433
Cdd:cd00063     82 ESPPSeSVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 617-688 5.19e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 5.19e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1679807465   617 PISHLHFSHVTSSSVNITWSDPSPPADRL-ILNYSPRDEEEDM--LEVLLDATKRHAVLMGLQPATEYIVNLVAV 688
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 436-510 6.82e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 6.82e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1679807465   436 DAPKNLRVGSRTATSLDLEWDNSEAEAQE-YKVVYSTLAGEQYHEVLVPKGIGPTTKTTLTDLVPGTEYGVGISAV 510
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITgYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
fn3 pfam00041
Fibronectin type III domain;
436-510 1.60e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.11  E-value: 1.60e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1679807465  436 DAPKNLRVGSRTATSLDLEW---DNSEAEAQEYKVVYSTLAGEQY-HEVLVPkgiGPTTKTTLTDLVPGTEYGVGISAV 510
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPwNEITVP---GTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
795-867 3.58e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 3.58e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  795 DSPMDLIATNITPTEALLQWKAPM---GEVENYVIVLTHfaiAGE-----TILVDGVSEEFQLVDLLPSTHYTVTMYATS 866
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRP---KNSgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   .
gi 1679807465  867 G 867
Cdd:pfam00041   78 G 78
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 257-327 2.01e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.84  E-value: 2.01e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1679807465   257 STPQGLQFKTITETTVEVQWEPFSFSFDGW-EISFIPKNNEGG---VIAQLPSDVTSFNQTGLKPGEEYIVNVVA 327
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 346-424 6.96e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 6.96e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465   346 DGPTQILVRDVSDTVAFVEWTPP-RAKVDFILLKYGLVGGEGGKTTFRL--QPPLSQYSVQALRPGSRYEVSISAVRGIN 422
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1679807465   423 ES 424
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 795-867 1.24e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 1.24e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1679807465   795 DSPMDLIATNITPTEALLQWKAP-----MGEVENYVIVLTHFAIAGETILVDGVSEEFQLVDLLPSTHYTVTMYATSG 867
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 795-876 5.42e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 5.42e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  795 DSPMDLIATNITPTEALLQWKAP---MGEVENYVIVLT-HFAIAGETILVDGVSE-EFQLVDLLPSTHYTVTMYA----- 864
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYReKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAvnggg 81

                           90
                   ....*....|..
gi 1679807465  865 TSGPLMSGTIAT 876
Cdd:cd00063     82 ESPPSESVTVTT 93
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
175-620 2.04e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 45.71  E-value: 2.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  175 VAGISDRSIELEWDGPMAVTEY-VISYQPTALGGLQLqqRV----PGDWSGVTITelepGLTYNISVYAVISN-----IL 244
Cdd:COG4733    455 VQSVAGRTLTVSTAYSETPEAGaVWAFGPDELETQLF--RVvsieENEDGTYTIT----AVQHAPEKYAAIDAgafddVP 528

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  245 SLPITAKVATHLSTPQGLQfkTITETTVEVQWEPfSFSFDGWEISFipKNNEGGVIAQLPSDVTSFNQTGLKPGEeYIVN 324
Cdd:COG4733    529 PQWPPVNVTTSESLSVVAQ--GTAVTTLTVSWDA-PAGAVAYEVEW--RRDDGNWVSVPRTSGTSFEVPGIYAGD-YEVR 602

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  325 VVALKEQARSPPISASVSTVIDG-------PTQILVrDVSDTVAFVEWTPPrakVDFILLKYGL---VGGEGGKTTFRLQ 394
Cdd:COG4733    603 VRAINALGVSSAWAASSETTVTGktapppaPTGLTA-TGGLGGITLSWSFP---VDADTLRTEIrysTTGDWASATVAQA 678

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  395 P-PLSQYSVQALRPGSRYEVSISAV-RGINESD-ASSTQFTTEIDAPKNLRVGSRTATSLDLEWDNSEAEAQeykvvyst 471
Cdd:COG4733    679 LyPGNTYTLAGLKAGQTYYYRARAVdRSGNVSAwWVSGQASADAAGILDAITGQILETELGQELDAIIQNAT-------- 750

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  472 lageqyhevlvpkgIGPTTKTTLTDLVPGTEYGVGISAVMNSKQSIPATMNARTELDSPRDLMVTASSETSISLIWTK-- 549
Cdd:COG4733    751 --------------VAEVVAATVTDVTAQIDTAVLFAGVATAAAIGAEARVAATVAESATAAAATGTAADAAGDASGGvt 816

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1679807465  550 ------ASGPIDHYRITFTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITAERGRQQSLESTVDAFTGFRPISH 620
Cdd:COG4733    817 agtsgtTGAGDTAASTTRVAAAVVLAGVVVYGDAIIESGNTGDIVATGDIASAAAGAVATTVSGTTAADVSAVADST 893
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
686-968 2.47e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 41.91  E-value: 2.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  686 VAVHGTVTSEPIVGSITTGIDPPKNITIGNVTK---DSLTVSWSPPVAPFDYYRVSYRPTQVG---RLDSSVVPNTVTEF 759
Cdd:COG3401    115 DEVPSPAVGTATTATAVAGGAATAGTYALGAGLygvDGANASGTTASSVAGAGVVVSPDTSATaavATTSLTVTSTTLVD 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  760 TITRLYPATEYEISL---NSVRGREESERIC-TLVHTAMDSPMDLIATNITPTEALLQWKAPMGEVENYVIVLTHFAIAG 835
Cdd:COG3401    195 GGGDIEPGTTYYYRVaatDTGGESAPSNEVSvTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDG 274

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1679807465  836 ETILVDGVSE-EFQLVDLLPSTHYTVTMYA------TSGPlmSGTI-ATNFSTLLDPPDNLTASEVTRQSALISWQPPRA 907
Cdd:COG3401    275 PFTKVATVTTtSYTDTGLTNGTTYYYRVTAvdaagnESAP--SNVVsVTTDLTPPAAPSGLTATAVGSSSITLSWTASSD 352

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1679807465  908 A-IENYVLTYKSTDGSRKELIVD-AEDTWIRLEGLSENTDYTVLLQAAQEATRSSLTSTVFTT 968
Cdd:COG3401    353 AdVTGYNVYRSTSGGGTYTKIAEtVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSA 415
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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