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Conserved domains on  [gi|1678570863|gb|QCY09293|]
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AraC family transcriptional regulator (plasmid) [Burkholderia cepacia ATCC 25416]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 14398393)

AraC family transcriptional regulator containing a cupin domain as its effector domain and an AraC family helix-turn-helix (HTH) DNA binding domain, controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  2.60.120.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0043565
PubMed:  11264412|11282467|33837749|9409145|12270809|19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 40-121 3.54e-24

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


:

Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 93.02  E-value: 3.54e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863  40 ELPMHVHRKGQLVVALSGSVMCRSPSGWWIVPPNGAVWIPGGIPHSNHASDFAKLYVIFIPPDE-AGLPTDCRSFTITPL 118
Cdd:cd06124    13 RTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAaAGLPAEPCVLAVSPL 92


                  ...
gi 1678570863 119 IRE 121
Cdd:cd06124    93 LRE 95
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
77-264 4.77e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 92.15  E-value: 4.77e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863  77 WIPGGIPHSNHASDFAKLYVIFIPPDEAGLPTDCRSFTITPLIRELIRSLARFPPDYPKDGPVGRLARVLLDQLALLAPD 156
Cdd:COG2207    63 LLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863 157 DVFLPISDNPRLQQIASALLDNPADRSTIAEWGRRYAMSERTLARLVRSETGMTFGRWRERLHIIIALQRLSAGA-SVHA 235
Cdd:COG2207   143 LLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDlSISE 222

                         170       180
                  ....*....|....*....|....*....
gi 1678570863 236 VALELGYEGPNSFITMFKKTMGQSPGKFR 264
Cdd:COG2207   223 IAYELGFSSQSHFSRAFKKRFGVTPSEYR 251
 
Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 40-121 3.54e-24

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 93.02  E-value: 3.54e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863  40 ELPMHVHRKGQLVVALSGSVMCRSPSGWWIVPPNGAVWIPGGIPHSNHASDFAKLYVIFIPPDE-AGLPTDCRSFTITPL 118
Cdd:cd06124    13 RTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAaAGLPAEPCVLAVSPL 92


                  ...
gi 1678570863 119 IRE 121
Cdd:cd06124    93 LRE 95
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
77-264 4.77e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 92.15  E-value: 4.77e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863  77 WIPGGIPHSNHASDFAKLYVIFIPPDEAGLPTDCRSFTITPLIRELIRSLARFPPDYPKDGPVGRLARVLLDQLALLAPD 156
Cdd:COG2207    63 LLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863 157 DVFLPISDNPRLQQIASALLDNPADRSTIAEWGRRYAMSERTLARLVRSETGMTFGRWRERLHIIIALQRLSAGA-SVHA 235
Cdd:COG2207   143 LLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDlSISE 222

                         170       180
                  ....*....|....*....|....*....
gi 1678570863 236 VALELGYEGPNSFITMFKKTMGQSPGKFR 264
Cdd:COG2207   223 IAYELGFSSQSHFSRAFKKRFGVTPSEYR 251
HTH_18 pfam12833
Helix-turn-helix domain;
188-264 2.20e-21

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 85.33  E-value: 2.20e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1678570863 188 WGRRYAMSERTLARLVRSETGMTFGRWRERLHIIIALQRL--SAGASVHAVALELGYEGPNSFITMFKKTMGQSPGKFR 264
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLleDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
184-264 3.45e-20

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 82.22  E-value: 3.45e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863  184 TIAEWGRRYAMSERTLARLVRSETGMTFGRWRERLHIIIALQRLSAGA-SVHAVALELGYEGPNSFITMFKKTMGQSPGK 262
Cdd:smart00342   3 TLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDlSVTEIALRVGFSSQSYFSRAFKKLFGVTPSE 82


                   ..
gi 1678570863  263 FR 264
Cdd:smart00342  83 YR 84
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
142-264 3.32e-13

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 68.08  E-value: 3.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863 142 LARVLLDQLAL----LAPDDVFLPIsdNPRLQQIASALLDNPADRSTIAEWGRRYAMSERTLARLVRSETGMTFGRWRER 217
Cdd:PRK10572  157 LAMNLLERLLLrcmeAIPESLHPPM--DPRVREACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWRED 234

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1678570863 218 LHIIIALQRLS-AGASVHAVALELGYEGPNSFITMFKKTMGQSPGKFR 264
Cdd:PRK10572  235 QRISRAKLLLQtTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPSEFR 282
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
28-101 8.04e-09

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 52.16  E-value: 8.04e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1678570863  28 ISVLLETSGKEDELPMHVHRKGQLVVALSGSVMCRSPSGWWIVPPNGAVWIPGGIPHS--NHASDFAKLYVIFIPP 101
Cdd:COG1917    23 LEVVRVTFEPGARTPWHSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAfrNLGDEPAVLLVVFSPG 98
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 42-157 7.31e-06

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 44.73  E-value: 7.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863  42 PMHVHRKGQLVVALSGSVMCRSPSGWWIVPPNGAVWIPGGIPHSNHASDFA--KLYVIFIPPDEAGlptdcrsftitpLI 119
Cdd:pfam02311  17 PPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDgwRYRWLYFEPELLE------------RI 84

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1678570863 120 RELIRSLARFPPDYPKDGPVGRLARVLLDQLALLAPDD 157
Cdd:pfam02311  85 LADISILAGGPLPLLRDPELAALLRALFRLLEEAGRSD 122
ASKHA_NBD_LGK cd24051
nucleotide-binding domain (NBD) of levoglucosan kinase (LGK) and similar proteins; LGK (EC 2.7. ...
 96-150 2.06e-03

nucleotide-binding domain (NBD) of levoglucosan kinase (LGK) and similar proteins; LGK (EC 2.7.1.232) catalyzes the transfer of a phosphate group from ATP to levoglucosan (1,6-anhydro-beta-D-glucopyranose, LG) to yield glucose 6-phosphate in the presence of magnesium ion and ATP. In addition to the canonical kinase phosphotransfer reaction, the conversion requires cleavage of the 1,6-anhydro ring to allow ATP-dependent phosphorylation of the sugar O-6 atom.


Pssm-ID: 466901  Cd Length: 409  Bit Score: 39.07  E-value: 2.06e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1678570863  96 VIFIPPDEAGLPTDCRSFTITP---LIRELIRSLARFPPDYPKDGPVGRLARV---LLDQL 150
Cdd:cd24051   180 VCFIPPDNDGRTDEYYDFDTGPgnvFIDAVVRHFTNGEQEYDKDGAMGKRGKVdqeLVDDF 240
 
Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 40-121 3.54e-24

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 93.02  E-value: 3.54e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863  40 ELPMHVHRKGQLVVALSGSVMCRSPSGWWIVPPNGAVWIPGGIPHSNHASDFAKLYVIFIPPDE-AGLPTDCRSFTITPL 118
Cdd:cd06124    13 RTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAaAGLPAEPCVLAVSPL 92


                  ...
gi 1678570863 119 IRE 121
Cdd:cd06124    93 LRE 95
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
77-264 4.77e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 92.15  E-value: 4.77e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863  77 WIPGGIPHSNHASDFAKLYVIFIPPDEAGLPTDCRSFTITPLIRELIRSLARFPPDYPKDGPVGRLARVLLDQLALLAPD 156
Cdd:COG2207    63 LLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863 157 DVFLPISDNPRLQQIASALLDNPADRSTIAEWGRRYAMSERTLARLVRSETGMTFGRWRERLHIIIALQRLSAGA-SVHA 235
Cdd:COG2207   143 LLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDlSISE 222

                         170       180
                  ....*....|....*....|....*....
gi 1678570863 236 VALELGYEGPNSFITMFKKTMGQSPGKFR 264
Cdd:COG2207   223 IAYELGFSSQSHFSRAFKKRFGVTPSEYR 251
HTH_18 pfam12833
Helix-turn-helix domain;
188-264 2.20e-21

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 85.33  E-value: 2.20e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1678570863 188 WGRRYAMSERTLARLVRSETGMTFGRWRERLHIIIALQRL--SAGASVHAVALELGYEGPNSFITMFKKTMGQSPGKFR 264
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLleDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
184-264 3.45e-20

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 82.22  E-value: 3.45e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863  184 TIAEWGRRYAMSERTLARLVRSETGMTFGRWRERLHIIIALQRLSAGA-SVHAVALELGYEGPNSFITMFKKTMGQSPGK 262
Cdd:smart00342   3 TLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDlSVTEIALRVGFSSQSYFSRAFKKLFGVTPSE 82


                   ..
gi 1678570863  263 FR 264
Cdd:smart00342  83 YR 84
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 164-264 9.54e-17

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 78.28  E-value: 9.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863 164 DNPRLQQIASALLDNPADRSTIAEWGRRYAMSERTLARLVRSETGMTFGRWRERLHIIIALQRLSAGA-SVHAVALELGY 242
Cdd:COG4977   208 RDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDlSIEEIAAACGF 287

                          90       100
                  ....*....|....*....|..
gi 1678570863 243 EGPNSFITMFKKTMGQSPGKFR 264
Cdd:COG4977   288 GSASHFRRAFRRRFGVSPSAYR 309
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
142-264 3.32e-13

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 68.08  E-value: 3.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863 142 LARVLLDQLAL----LAPDDVFLPIsdNPRLQQIASALLDNPADRSTIAEWGRRYAMSERTLARLVRSETGMTFGRWRER 217
Cdd:PRK10572  157 LAMNLLERLLLrcmeAIPESLHPPM--DPRVREACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWRED 234

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1678570863 218 LHIIIALQRLS-AGASVHAVALELGYEGPNSFITMFKKTMGQSPGKFR 264
Cdd:PRK10572  235 QRISRAKLLLQtTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPSEFR 282
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 155-264 5.20e-13

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 68.16  E-value: 5.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863 155 PDDVFLPISDNPRLQQIASALLDNPADRSTIAEWGRRYAMSERTLARLVRSETGMTFGRWRERLHIIIALQRLSAGASVH 234
Cdd:COG2169    73 PDLAPGSPPRADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGLSVT 152

                          90       100       110
                  ....*....|....*....|....*....|
gi 1678570863 235 AVALELGYEGPNSFITMFKKTMGQSPGKFR 264
Cdd:COG2169   153 DAAYAAGFGSLSRFYEAFKKLLGMTPSAYR 182
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
28-101 8.04e-09

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 52.16  E-value: 8.04e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1678570863  28 ISVLLETSGKEDELPMHVHRKGQLVVALSGSVMCRSPSGWWIVPPNGAVWIPGGIPHS--NHASDFAKLYVIFIPP 101
Cdd:COG1917    23 LEVVRVTFEPGARTPWHSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAfrNLGDEPAVLLVVFSPG 98
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
119-264 1.86e-08

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 53.91  E-value: 1.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863 119 IRELIRSLARFPPDYpkDGPVGRLARVLLDQLALLAPDDVFLPISDNP--RLQQIASALLDNPADRSTIAEWGRRYAMSE 196
Cdd:PRK13503  124 VRQLVAQMEQQEESN--DLEAIASREILFMQLLVLLRKSSLQENGENSdaRLNQLLAWLEDHFAEEVNWEALADQFSLSL 201

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1678570863 197 RTLARLVRSETGMTFGRWRERLHIIIALQRLS-AGASVHAVALELGYEGPNSFITMFKKTMGQSPGKFR 264
Cdd:PRK13503  202 RTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRhSDASVTDIAYRCGFGDSNHFSTLFRREFSWSPRDIR 270
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
118-264 8.04e-08

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 52.21  E-value: 8.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863 118 LIRELIRSLARfppDYPKDGPVGR-LARVLLDQLALL------APDDVFLpISDNPRLQQIASALLDNPADRSTIAEWGR 190
Cdd:PRK13501  125 QARPIIQQLAQ---ESRKTDSWSIqLTEVLLLQLAIVlkrhryRAEQAHL-LPDGEQLDLIMSALQQSLGAYFDMADFCH 200

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1678570863 191 RYAMSERTLARLVRSETGMTFGRWRERLHIIIALQRLSAGAS-VHAVALELGYEGPNSFITMFKKTMGQSPGKFR 264
Cdd:PRK13501  201 KNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHrISDIAARCGFEDSNYFSAVFTREAGMTPRDYR 275
ftrA PRK09393
transcriptional activator FtrA; Provisional
 167-264 1.24e-07

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 51.89  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863 167 RLQQIASALLDNPADRSTIAEWGRRYAMSERTLARLVRSETGMTFGRW--RERLHiiIALQRL-SAGASVHAVALELGYE 243
Cdd:PRK09393  219 RLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWllRERLA--RARDLLeSSALSIDQIAERAGFG 296

                          90       100
                  ....*....|....*....|.
gi 1678570863 244 GPNSFITMFKKTMGQSPGKFR 264
Cdd:PRK09393  297 SEESLRHHFRRRAATSPAAYR 317
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 42-157 7.31e-06

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 44.73  E-value: 7.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863  42 PMHVHRKGQLVVALSGSVMCRSPSGWWIVPPNGAVWIPGGIPHSNHASDFA--KLYVIFIPPDEAGlptdcrsftitpLI 119
Cdd:pfam02311  17 PPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDgwRYRWLYFEPELLE------------RI 84

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1678570863 120 RELIRSLARFPPDYPKDGPVGRLARVLLDQLALLAPDD 157
Cdd:pfam02311  85 LADISILAGGPLPLLRDPELAALLRALFRLLEEAGRSD 122
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
135-264 1.18e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 45.82  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863 135 KDGPVGRLARVLLDQLAL------LAPDDvfLPISDNPRLQQIASALLDNPADRSTIAE-WGRRYAMSERTLARLVRSET 207
Cdd:PRK13502  140 RDPLANEMAELLFGQLVMtlkrhrYATDD--LPATSRETLLDKLITALANSLECPFALDaFCQQEQCSERVLRQQFRAQT 217

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1678570863 208 GMTFGRWRERLHIIIALQRLS-AGASVHAVALELGYEGPNSFITMFKKTMGQSPGKFR 264
Cdd:PRK13502  218 GMTINQYLRQVRICHAQYLLQhSPLMISEISMQCGFEDSNYFSVVFTRETGMTPSQWR 275
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
40-101 3.67e-05

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 42.05  E-value: 3.67e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1678570863  40 ELPMHVHRKG-QLVVALSGSVMCRSPSGWWIVPPNGAVWIPGGIPHS--NHASDFAKLYVIFIPP 101
Cdd:COG0662    39 ELSLHVHPHRdEFFYVLEGTGEVTIGDEEVELKAGDSVYIPAGVPHRlrNPGDEPLELLEVQAPA 103
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
142-264 3.55e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 41.24  E-value: 3.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863 142 LARVLLDQLALLA-----PDDVFLPISDNPRLQQIASALLDNPADRSTIAEWGRRYAMSERTLARLVRSETGMTFGRWRE 216
Cdd:PRK13500  177 MAELLFGQLVMLLnrhryTSDSLPPTSSETLLDKLITRLAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLR 256

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1678570863 217 RLHIIIALQRLS-AGASVHAVALELGYEGPNSFITMFKKTMGQSPGKFR 264
Cdd:PRK13500  257 QVRVCHAQYLLQhSRLLISDISTECGFEDSNYFSVVFTRETGMTPSQWR 305
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 175-215 5.15e-04

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 36.75  E-value: 5.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1678570863 175 LLDNPADRSTIAEWGRRYAMSERTLARLVRSETGMTFGRWR 215
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYR 41
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
169-264 8.21e-04

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 37.98  E-value: 8.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863 169 QQIASAL---LDNPADRS-TIAEWGRRYAMSERTLARLVRSETGMTFGRW-RERLHIIIALQRLSAGASVHAVALELGYE 243
Cdd:PRK10219    4 QKIIQTLiawIDEHIDQPlNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYiRQRRLLLAAVELRTTERPIFDIAMDLGYV 83

                          90       100
                  ....*....|....*....|.
gi 1678570863 244 GPNSFITMFKKTMGQSPGKFR 264
Cdd:PRK10219   84 SQQTFSRVFRRQFDRTPSDYR 104
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
163-273 1.27e-03

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 38.16  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863 163 SDNPRLQQIASALLDNPADRSTIAEWGRRYAMSERTLARLVRSETGMTFGRW-RERLHIIIALQRLSAGASVHAVALELG 241
Cdd:PRK11511    6 TDAITIHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYiRSRKMTEIAQKLKESNEPILYLAERYG 85

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1678570863 242 YEGPNSFITMFKKTMGQSPGKFRVDQKEASSR 273
Cdd:PRK11511   86 FESQQTLTRTFKNYFDVPPHKYRMTNMQGESR 117
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
161-264 1.93e-03

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 39.01  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678570863 161 PISDNP---RLQQIASA--LL--DNPAdrsTIAEWGRRYAMSERTLARLVRSETGMTFGRWRERLHIIIALQRLSAGASV 233
Cdd:PRK15435   74 PDKANPqqhRLDKITHAcrLLeqETPV---TLEALADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRLREALAKGESV 150

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1678570863 234 HAVALELGYEGPNSFITMFKKTMGQSPGKFR 264
Cdd:PRK15435  151 TTSILNAGFPDSSSYYRKADETLGMTAKQFR 181
ASKHA_NBD_LGK cd24051
nucleotide-binding domain (NBD) of levoglucosan kinase (LGK) and similar proteins; LGK (EC 2.7. ...
 96-150 2.06e-03

nucleotide-binding domain (NBD) of levoglucosan kinase (LGK) and similar proteins; LGK (EC 2.7.1.232) catalyzes the transfer of a phosphate group from ATP to levoglucosan (1,6-anhydro-beta-D-glucopyranose, LG) to yield glucose 6-phosphate in the presence of magnesium ion and ATP. In addition to the canonical kinase phosphotransfer reaction, the conversion requires cleavage of the 1,6-anhydro ring to allow ATP-dependent phosphorylation of the sugar O-6 atom.


Pssm-ID: 466901  Cd Length: 409  Bit Score: 39.07  E-value: 2.06e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1678570863  96 VIFIPPDEAGLPTDCRSFTITP---LIRELIRSLARFPPDYPKDGPVGRLARV---LLDQL 150
Cdd:cd24051   180 VCFIPPDNDGRTDEYYDFDTGPgnvFIDAVVRHFTNGEQEYDKDGAMGKRGKVdqeLVDDF 240
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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