slit homolog 3 protein isoform 1 precursor [Homo sapiens]
List of domain hits
Name | Accession | Description | Interval | E-value | ||||||
Laminin_G_2 | pfam02210 | Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
1195-1321 | 1.39e-31 | ||||||
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily. : Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 120.22 E-value: 1.39e-31
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
62-217 | 1.06e-27 | ||||||
Leucine-rich repeat (LRR) protein [Transcription]; : Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 117.73 E-value: 1.06e-27
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
588-900 | 1.35e-22 | ||||||
Leucine-rich repeat (LRR) protein [Transcription]; : Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 102.32 E-value: 1.35e-22
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
326-666 | 1.88e-19 | ||||||
Leucine-rich repeat (LRR) protein [Transcription]; : Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 92.69 E-value: 1.88e-19
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1081-1117 | 1.81e-07 | ||||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. : Pssm-ID: 238011 Cd Length: 38 Bit Score: 48.79 E-value: 1.81e-07
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1005-1038 | 5.99e-06 | ||||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. : Pssm-ID: 238011 Cd Length: 38 Bit Score: 44.55 E-value: 5.99e-06
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EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1130-1160 | 3.93e-05 | ||||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. : Pssm-ID: 394967 Cd Length: 31 Bit Score: 41.98 E-value: 3.93e-05
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
963-1001 | 4.10e-05 | ||||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. : Pssm-ID: 238011 Cd Length: 38 Bit Score: 41.85 E-value: 4.10e-05
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1042-1079 | 4.84e-05 | ||||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. : Pssm-ID: 238011 Cd Length: 38 Bit Score: 41.85 E-value: 4.84e-05
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LRRNT | smart00013 | Leucine rich repeat N-terminal domain; |
33-64 | 8.72e-05 | ||||||
Leucine rich repeat N-terminal domain; : Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 41.15 E-value: 8.72e-05
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PCC super family | cl28216 | polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
188-250 | 1.02e-04 | ||||||
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half. The actual alignment was detected with superfamily member TIGR00864: Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 47.38 E-value: 1.02e-04
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GHB_like super family | cl21545 | Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ... |
1473-1528 | 3.56e-04 | ||||||
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer. The actual alignment was detected with superfamily member smart00041: Pssm-ID: 473907 Cd Length: 82 Bit Score: 40.85 E-value: 3.56e-04
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LRRNT | smart00013 | Leucine rich repeat N-terminal domain; |
280-311 | 1.54e-03 | ||||||
Leucine rich repeat N-terminal domain; : Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 37.30 E-value: 1.54e-03
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EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1379-1407 | 3.33e-03 | ||||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. : Pssm-ID: 394967 Cd Length: 31 Bit Score: 36.59 E-value: 3.33e-03
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Name | Accession | Description | Interval | E-value | ||||||
Laminin_G_2 | pfam02210 | Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
1195-1321 | 1.39e-31 | ||||||
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily. Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 120.22 E-value: 1.39e-31
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LamG | smart00282 | Laminin G domain; |
1188-1321 | 3.63e-30 | ||||||
Laminin G domain; Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 116.67 E-value: 3.63e-30
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LamG | cd00110 | Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
1166-1319 | 3.79e-30 | ||||||
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules. Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 117.13 E-value: 3.79e-30
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
62-217 | 1.06e-27 | ||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 117.73 E-value: 1.06e-27
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
588-900 | 1.35e-22 | ||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 102.32 E-value: 1.35e-22
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
326-666 | 1.88e-19 | ||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 92.69 E-value: 1.88e-19
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
61-217 | 1.17e-15 | ||||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 77.52 E-value: 1.17e-15
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LRR_8 | pfam13855 | Leucine rich repeat; |
775-835 | 1.14e-14 | ||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 69.86 E-value: 1.14e-14
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LRR_8 | pfam13855 | Leucine rich repeat; |
557-617 | 6.85e-13 | ||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 64.85 E-value: 6.85e-13
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LRR_8 | pfam13855 | Leucine rich repeat; |
159-217 | 3.90e-12 | ||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 62.54 E-value: 3.90e-12
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PCC | TIGR00864 | polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
636-714 | 2.19e-11 | ||||||
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half. Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 69.34 E-value: 2.19e-11
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
734-860 | 1.59e-09 | ||||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 59.80 E-value: 1.59e-09
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PRK15370 | PRK15370 | type III secretion system effector E3 ubiquitin transferase SlrP; |
522-790 | 3.42e-09 | ||||||
type III secretion system effector E3 ubiquitin transferase SlrP; Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 61.64 E-value: 3.42e-09
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1081-1117 | 1.81e-07 | ||||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 48.79 E-value: 1.81e-07
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LRRCT | smart00082 | Leucine rich repeat C-terminal domain; |
857-906 | 4.57e-07 | ||||||
Leucine rich repeat C-terminal domain; Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 47.81 E-value: 4.57e-07
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PRK15370 | PRK15370 | type III secretion system effector E3 ubiquitin transferase SlrP; |
255-536 | 1.83e-06 | ||||||
type III secretion system effector E3 ubiquitin transferase SlrP; Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 52.78 E-value: 1.83e-06
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PRK15370 | PRK15370 | type III secretion system effector E3 ubiquitin transferase SlrP; |
52-217 | 2.77e-06 | ||||||
type III secretion system effector E3 ubiquitin transferase SlrP; Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 52.01 E-value: 2.77e-06
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1081-1117 | 2.97e-06 | ||||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 45.32 E-value: 2.97e-06
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1005-1038 | 5.99e-06 | ||||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 44.55 E-value: 5.99e-06
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PCC | TIGR00864 | polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
410-473 | 2.19e-05 | ||||||
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half. Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 49.70 E-value: 2.19e-05
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EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1007-1036 | 3.49e-05 | ||||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 41.98 E-value: 3.49e-05
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EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1130-1160 | 3.93e-05 | ||||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 41.98 E-value: 3.93e-05
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
963-1001 | 4.10e-05 | ||||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 41.85 E-value: 4.10e-05
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EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1085-1115 | 4.29e-05 | ||||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 41.98 E-value: 4.29e-05
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1042-1079 | 4.84e-05 | ||||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 41.85 E-value: 4.84e-05
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LRRNT | smart00013 | Leucine rich repeat N-terminal domain; |
33-64 | 8.72e-05 | ||||||
Leucine rich repeat N-terminal domain; Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 41.15 E-value: 8.72e-05
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LRRNT | pfam01462 | Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ... |
33-60 | 8.94e-05 | ||||||
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats. Pssm-ID: 396168 [Multi-domain] Cd Length: 28 Bit Score: 40.69 E-value: 8.94e-05
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PCC | TIGR00864 | polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
188-250 | 1.02e-04 | ||||||
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half. Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 47.38 E-value: 1.02e-04
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1005-1034 | 1.97e-04 | ||||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 40.31 E-value: 1.97e-04
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
55-415 | 2.93e-04 | ||||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 45.61 E-value: 2.93e-04
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CT | smart00041 | C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ... |
1473-1528 | 3.56e-04 | ||||||
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers. Pssm-ID: 214482 Cd Length: 82 Bit Score: 40.85 E-value: 3.56e-04
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LRRCT | smart00082 | Leucine rich repeat C-terminal domain; |
437-467 | 7.17e-04 | ||||||
Leucine rich repeat C-terminal domain; Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 38.95 E-value: 7.17e-04
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1042-1079 | 7.87e-04 | ||||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 38.38 E-value: 7.87e-04
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LRRNT | smart00013 | Leucine rich repeat N-terminal domain; |
280-311 | 1.54e-03 | ||||||
Leucine rich repeat N-terminal domain; Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 37.30 E-value: 1.54e-03
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LRRNT | pfam01462 | Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ... |
280-306 | 1.88e-03 | ||||||
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats. Pssm-ID: 396168 [Multi-domain] Cd Length: 28 Bit Score: 37.22 E-value: 1.88e-03
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EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1379-1407 | 3.33e-03 | ||||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 36.59 E-value: 3.33e-03
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EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
966-999 | 3.93e-03 | ||||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 36.21 E-value: 3.93e-03
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
969-1001 | 5.37e-03 | ||||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 36.07 E-value: 5.37e-03
|
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LRR_TYP | smart00369 | Leucine-rich repeats, typical (most populated) subfamily; |
133-155 | 6.15e-03 | ||||||
Leucine-rich repeats, typical (most populated) subfamily; Pssm-ID: 197687 [Multi-domain] Cd Length: 24 Bit Score: 35.41 E-value: 6.15e-03
|
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Name | Accession | Description | Interval | E-value | ||||||||
Laminin_G_2 | pfam02210 | Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
1195-1321 | 1.39e-31 | ||||||||
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily. Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 120.22 E-value: 1.39e-31
|
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LamG | smart00282 | Laminin G domain; |
1188-1321 | 3.63e-30 | ||||||||
Laminin G domain; Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 116.67 E-value: 3.63e-30
|
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LamG | cd00110 | Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
1166-1319 | 3.79e-30 | ||||||||
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules. Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 117.13 E-value: 3.79e-30
|
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
62-217 | 1.06e-27 | ||||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 117.73 E-value: 1.06e-27
|
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
61-455 | 2.17e-24 | ||||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 107.71 E-value: 2.17e-24
|
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
62-450 | 1.02e-23 | ||||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 105.79 E-value: 1.02e-23
|
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
588-900 | 1.35e-22 | ||||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 102.32 E-value: 1.35e-22
|
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
535-837 | 1.50e-22 | ||||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 102.32 E-value: 1.50e-22
|
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
633-859 | 1.28e-20 | ||||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 96.54 E-value: 1.28e-20
|
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
326-666 | 1.88e-19 | ||||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 92.69 E-value: 1.88e-19
|
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
107-482 | 6.49e-18 | ||||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 88.07 E-value: 6.49e-18
|
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Laminin_G_1 | pfam00054 | Laminin G domain; |
1193-1324 | 8.01e-18 | ||||||||
Laminin G domain; Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 81.21 E-value: 8.01e-18
|
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
61-217 | 1.17e-15 | ||||||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 77.52 E-value: 1.17e-15
|
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LRR_8 | pfam13855 | Leucine rich repeat; |
775-835 | 1.14e-14 | ||||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 69.86 E-value: 1.14e-14
|
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LRR_8 | pfam13855 | Leucine rich repeat; |
557-617 | 6.85e-13 | ||||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 64.85 E-value: 6.85e-13
|
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LRR_8 | pfam13855 | Leucine rich repeat; |
582-641 | 1.18e-12 | ||||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 64.08 E-value: 1.18e-12
|
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LRR_8 | pfam13855 | Leucine rich repeat; |
159-217 | 3.90e-12 | ||||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 62.54 E-value: 3.90e-12
|
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LRR_8 | pfam13855 | Leucine rich repeat; |
61-121 | 4.25e-12 | ||||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 62.54 E-value: 4.25e-12
|
||||||||||||
LRR_8 | pfam13855 | Leucine rich repeat; |
133-193 | 4.51e-12 | ||||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 62.54 E-value: 4.51e-12
|
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LRR_8 | pfam13855 | Leucine rich repeat; |
311-367 | 6.60e-12 | ||||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 61.77 E-value: 6.60e-12
|
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LRR_8 | pfam13855 | Leucine rich repeat; |
799-859 | 1.70e-11 | ||||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 60.62 E-value: 1.70e-11
|
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LRR_8 | pfam13855 | Leucine rich repeat; |
86-145 | 1.74e-11 | ||||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 60.62 E-value: 1.74e-11
|
||||||||||||
LRR_8 | pfam13855 | Leucine rich repeat; |
605-665 | 1.79e-11 | ||||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 60.62 E-value: 1.79e-11
|
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LRR_8 | pfam13855 | Leucine rich repeat; |
110-169 | 1.86e-11 | ||||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 60.62 E-value: 1.86e-11
|
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PCC | TIGR00864 | polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
636-714 | 2.19e-11 | ||||||||
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half. Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 69.34 E-value: 2.19e-11
|
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LRR_8 | pfam13855 | Leucine rich repeat; |
534-593 | 2.34e-10 | ||||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 57.53 E-value: 2.34e-10
|
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LRR_8 | pfam13855 | Leucine rich repeat; |
754-811 | 5.53e-10 | ||||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 56.38 E-value: 5.53e-10
|
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
734-860 | 1.59e-09 | ||||||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 59.80 E-value: 1.59e-09
|
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PCC | TIGR00864 | polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
830-912 | 3.39e-09 | ||||||||
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half. Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 62.02 E-value: 3.39e-09
|
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PRK15370 | PRK15370 | type III secretion system effector E3 ubiquitin transferase SlrP; |
522-790 | 3.42e-09 | ||||||||
type III secretion system effector E3 ubiquitin transferase SlrP; Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 61.64 E-value: 3.42e-09
|
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PLN03150 | PLN03150 | hypothetical protein; Provisional |
767-860 | 8.80e-09 | ||||||||
hypothetical protein; Provisional Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 60.21 E-value: 8.80e-09
|
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PRK15370 | PRK15370 | type III secretion system effector E3 ubiquitin transferase SlrP; |
697-859 | 1.13e-08 | ||||||||
type III secretion system effector E3 ubiquitin transferase SlrP; Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 60.10 E-value: 1.13e-08
|
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LRR_8 | pfam13855 | Leucine rich repeat; |
332-377 | 2.37e-08 | ||||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 51.76 E-value: 2.37e-08
|
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
52-203 | 4.39e-08 | ||||||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 57.25 E-value: 4.39e-08
|
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LRR_8 | pfam13855 | Leucine rich repeat; |
387-439 | 6.31e-08 | ||||||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 50.60 E-value: 6.31e-08
|
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
540-859 | 6.33e-08 | ||||||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 57.55 E-value: 6.33e-08
|
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1081-1117 | 1.81e-07 | ||||||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 48.79 E-value: 1.81e-07
|
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LRRCT | smart00082 | Leucine rich repeat C-terminal domain; |
857-906 | 4.57e-07 | ||||||||
Leucine rich repeat C-terminal domain; Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 47.81 E-value: 4.57e-07
|
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LRR_RI | cd00116 | Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
49-220 | 1.41e-06 | ||||||||
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1). Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.97 E-value: 1.41e-06
|
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PRK15370 | PRK15370 | type III secretion system effector E3 ubiquitin transferase SlrP; |
255-536 | 1.83e-06 | ||||||||
type III secretion system effector E3 ubiquitin transferase SlrP; Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 52.78 E-value: 1.83e-06
|
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PRK15370 | PRK15370 | type III secretion system effector E3 ubiquitin transferase SlrP; |
52-217 | 2.77e-06 | ||||||||
type III secretion system effector E3 ubiquitin transferase SlrP; Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 52.01 E-value: 2.77e-06
|
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1081-1117 | 2.97e-06 | ||||||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 45.32 E-value: 2.97e-06
|
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1005-1038 | 5.99e-06 | ||||||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 44.55 E-value: 5.99e-06
|
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
755-839 | 1.12e-05 | ||||||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 48.24 E-value: 1.12e-05
|
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PCC | TIGR00864 | polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
410-473 | 2.19e-05 | ||||||||
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half. Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 49.70 E-value: 2.19e-05
|
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
62-180 | 2.67e-05 | ||||||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 49.08 E-value: 2.67e-05
|
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
134-666 | 2.76e-05 | ||||||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 49.08 E-value: 2.76e-05
|
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EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1007-1036 | 3.49e-05 | ||||||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 41.98 E-value: 3.49e-05
|
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EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1130-1160 | 3.93e-05 | ||||||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 41.98 E-value: 3.93e-05
|
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
963-1001 | 4.10e-05 | ||||||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 41.85 E-value: 4.10e-05
|
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EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1085-1115 | 4.29e-05 | ||||||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 41.98 E-value: 4.29e-05
|
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RNA1 | COG5238 | Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
60-222 | 4.54e-05 | ||||||||
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis]; Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 47.86 E-value: 4.54e-05
|
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EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
1042-1079 | 4.84e-05 | ||||||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 41.85 E-value: 4.84e-05
|
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LRRCT | smart00082 | Leucine rich repeat C-terminal domain; |
663-712 | 7.68e-05 | ||||||||
Leucine rich repeat C-terminal domain; Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 41.65 E-value: 7.68e-05
|
||||||||||||
LRRNT | smart00013 | Leucine rich repeat N-terminal domain; |
33-64 | 8.72e-05 | ||||||||
Leucine rich repeat N-terminal domain; Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 41.15 E-value: 8.72e-05
|
||||||||||||
LRRNT | pfam01462 | Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ... |
33-60 | 8.94e-05 | ||||||||
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats. Pssm-ID: 396168 [Multi-domain] Cd Length: 28 Bit Score: 40.69 E-value: 8.94e-05
|
||||||||||||
PCC | TIGR00864 | polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
188-250 | 1.02e-04 | ||||||||
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half. Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 47.38 E-value: 1.02e-04
|
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LRRNT | smart00013 | Leucine rich repeat N-terminal domain; |
725-756 | 1.56e-04 | ||||||||
Leucine rich repeat N-terminal domain; Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 40.38 E-value: 1.56e-04
|
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LRR_RI | cd00116 | Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
65-215 | 1.60e-04 | ||||||||
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1). Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 45.42 E-value: 1.60e-04
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EGF | cd00053 | Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ... |
1088-1117 | 1.84e-04 | ||||||||
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium. Pssm-ID: 238010 Cd Length: 36 Bit Score: 40.15 E-value: 1.84e-04
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1005-1034 | 1.97e-04 | ||||||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 40.31 E-value: 1.97e-04
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Laminin_G_3 | pfam13385 | Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ... |
1171-1318 | 2.15e-04 | ||||||||
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily. Pssm-ID: 463865 [Multi-domain] Cd Length: 151 Bit Score: 43.14 E-value: 2.15e-04
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hEGF | pfam12661 | Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ... |
1090-1111 | 2.89e-04 | ||||||||
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue. Pssm-ID: 463660 Cd Length: 22 Bit Score: 39.24 E-value: 2.89e-04
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
55-415 | 2.93e-04 | ||||||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 45.61 E-value: 2.93e-04
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CT | smart00041 | C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ... |
1473-1528 | 3.56e-04 | ||||||||
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers. Pssm-ID: 214482 Cd Length: 82 Bit Score: 40.85 E-value: 3.56e-04
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LRR_4 | pfam12799 | Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
331-370 | 4.67e-04 | ||||||||
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 39.15 E-value: 4.67e-04
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
61-374 | 5.17e-04 | ||||||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 44.84 E-value: 5.17e-04
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LRRCT | smart00082 | Leucine rich repeat C-terminal domain; |
437-467 | 7.17e-04 | ||||||||
Leucine rich repeat C-terminal domain; Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 38.95 E-value: 7.17e-04
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
66-218 | 7.31e-04 | ||||||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 44.45 E-value: 7.31e-04
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
1042-1079 | 7.87e-04 | ||||||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 38.38 E-value: 7.87e-04
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
535-665 | 7.89e-04 | ||||||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 42.47 E-value: 7.89e-04
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LRRNT | smart00013 | Leucine rich repeat N-terminal domain; |
280-311 | 1.54e-03 | ||||||||
Leucine rich repeat N-terminal domain; Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 37.30 E-value: 1.54e-03
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LRRNT | pfam01462 | Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ... |
280-306 | 1.88e-03 | ||||||||
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats. Pssm-ID: 396168 [Multi-domain] Cd Length: 28 Bit Score: 37.22 E-value: 1.88e-03
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LRRNT | smart00013 | Leucine rich repeat N-terminal domain; |
505-535 | 2.19e-03 | ||||||||
Leucine rich repeat N-terminal domain; Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 36.91 E-value: 2.19e-03
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LRR | smart00370 | Leucine-rich repeats, outliers; |
556-579 | 2.37e-03 | ||||||||
Leucine-rich repeats, outliers; Pssm-ID: 197688 [Multi-domain] Cd Length: 24 Bit Score: 36.56 E-value: 2.37e-03
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LRR_TYP | smart00369 | Leucine-rich repeats, typical (most populated) subfamily; |
556-579 | 2.37e-03 | ||||||||
Leucine-rich repeats, typical (most populated) subfamily; Pssm-ID: 197687 [Multi-domain] Cd Length: 24 Bit Score: 36.56 E-value: 2.37e-03
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EGF | cd00053 | Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ... |
1008-1036 | 2.64e-03 | ||||||||
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium. Pssm-ID: 238010 Cd Length: 36 Bit Score: 37.07 E-value: 2.64e-03
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LRRNT | pfam01462 | Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ... |
725-751 | 2.86e-03 | ||||||||
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats. Pssm-ID: 396168 [Multi-domain] Cd Length: 28 Bit Score: 36.45 E-value: 2.86e-03
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EGF_3 | pfam12947 | EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ... |
1078-1113 | 3.14e-03 | ||||||||
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein. Pssm-ID: 463759 [Multi-domain] Cd Length: 36 Bit Score: 36.81 E-value: 3.14e-03
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hEGF | pfam12661 | Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ... |
1012-1031 | 3.25e-03 | ||||||||
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue. Pssm-ID: 463660 Cd Length: 22 Bit Score: 36.54 E-value: 3.25e-03
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EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
1379-1407 | 3.33e-03 | ||||||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 36.59 E-value: 3.33e-03
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LRR_5 | pfam13306 | BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ... |
71-177 | 3.55e-03 | ||||||||
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis. Pssm-ID: 463839 [Multi-domain] Cd Length: 127 Bit Score: 39.07 E-value: 3.55e-03
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EGF | pfam00008 | EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
966-999 | 3.93e-03 | ||||||||
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. Pssm-ID: 394967 Cd Length: 31 Bit Score: 36.21 E-value: 3.93e-03
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RNA1 | COG5238 | Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
324-456 | 5.26e-03 | ||||||||
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis]; Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 40.93 E-value: 5.26e-03
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EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
969-1001 | 5.37e-03 | ||||||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 36.07 E-value: 5.37e-03
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
55-567 | 5.52e-03 | ||||||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 41.37 E-value: 5.52e-03
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LRR_9 | pfam14580 | Leucine-rich repeat; |
539-622 | 5.77e-03 | ||||||||
Leucine-rich repeat; Pssm-ID: 405295 [Multi-domain] Cd Length: 175 Bit Score: 39.36 E-value: 5.77e-03
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LRR_TYP | smart00369 | Leucine-rich repeats, typical (most populated) subfamily; |
133-155 | 6.15e-03 | ||||||||
Leucine-rich repeats, typical (most populated) subfamily; Pssm-ID: 197687 [Multi-domain] Cd Length: 24 Bit Score: 35.41 E-value: 6.15e-03
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LRR | smart00370 | Leucine-rich repeats, outliers; |
133-155 | 6.15e-03 | ||||||||
Leucine-rich repeats, outliers; Pssm-ID: 197688 [Multi-domain] Cd Length: 24 Bit Score: 35.41 E-value: 6.15e-03
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LRR | smart00370 | Leucine-rich repeats, outliers; |
822-845 | 6.78e-03 | ||||||||
Leucine-rich repeats, outliers; Pssm-ID: 197688 [Multi-domain] Cd Length: 24 Bit Score: 35.41 E-value: 6.78e-03
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LRR_TYP | smart00369 | Leucine-rich repeats, typical (most populated) subfamily; |
822-845 | 6.78e-03 | ||||||||
Leucine-rich repeats, typical (most populated) subfamily; Pssm-ID: 197687 [Multi-domain] Cd Length: 24 Bit Score: 35.41 E-value: 6.78e-03
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LRR_4 | pfam12799 | Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
85-121 | 7.43e-03 | ||||||||
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 35.68 E-value: 7.43e-03
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LRR_4 | pfam12799 | Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
133-174 | 8.62e-03 | ||||||||
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 35.68 E-value: 8.62e-03
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Blast search parameters | ||||
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