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Conserved domains on  [gi|167599440|gb|ABZ88720|]
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growth hormone 2 isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
growth_hormone_like super family cl07831
Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes ...
 35-170 2.07e-47

Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes growth hormones 1 and 2, prolactin, prolactin 2, and other members that play vital roles in a variety of processes, including growth control. They are long-chain class-I helical cytokines, most of which are secreted by the pituitary gland, and are active as monomers, binding to cellular receptors with EpoR-like ligand binding domains.


The actual alignment was detected with superfamily member cd10285:

Pssm-ID: 324147  Cd Length: 180  Bit Score: 155.30  E-value: 2.07e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167599440  35 LFDNAMLRARRLYQLAYDTYQEFEEAYILKEQKYSFLQNPQtSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLE 114
Cdd:cd10285    1 LFSNAVLRAQHLHQLAADIYKDFERSYIPEEQRQSNKNSPA-AFCYSESIPAPTGKDETQQKSDLELLRISLLLIQSWLK 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 167599440 115 PVQLLRSVFANSLVyGASDSNVYRHLKDLEEGIQTLMWVRVAPGIPNPGAPLASRD 170
Cdd:cd10285   80 PVQFLSSVFTNQLH-FGSSDRIYEKLKDLEEGIQTLIRELEDGSPRGGQLLKQTYS 134
 
Name Accession Description Interval E-value
somatotropin_like cd10285
Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; ...
 35-170 2.07e-47

Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; Growth hormone (GH) or somatotropin is a peptide hormone synthesized by the pituitary gland, which mediates anabolic effects in development. GH is known to activate, via binding to specific cellular receptors, the MAPK/ERK and JAK-STAT signaling pathways. Via the latter, it triggers the secretion of insulin-like growth factor 1 (mostly in the liver). Besides increasing body height, GH has been shown to have a host of other effects.


Pssm-ID: 198435  Cd Length: 180  Bit Score: 155.30  E-value: 2.07e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167599440  35 LFDNAMLRARRLYQLAYDTYQEFEEAYILKEQKYSFLQNPQtSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLE 114
Cdd:cd10285    1 LFSNAVLRAQHLHQLAADIYKDFERSYIPEEQRQSNKNSPA-AFCYSESIPAPTGKDETQQKSDLELLRISLLLIQSWLK 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 167599440 115 PVQLLRSVFANSLVyGASDSNVYRHLKDLEEGIQTLMWVRVAPGIPNPGAPLASRD 170
Cdd:cd10285   80 PVQFLSSVFTNQLH-FGSSDRIYEKLKDLEEGIQTLIRELEDGSPRGGQLLKQTYS 134
Hormone_1 pfam00103
Somatotropin hormone family;
22-152 4.55e-38

Somatotropin hormone family;


Pssm-ID: 306585  Cd Length: 214  Bit Score: 132.50  E-value: 4.55e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167599440   22 QEGSAFPT---------IPLSRLFDNAMLRARRLYQLAYDTYQEFEEAYILKEQkySFLQnpQTSLCFSESIPTPSNRVK 92
Cdd:pfam00103  10 ENVASCPScapdnvgcrMSLEDLFDNATLLSHNMYNLASDMFTEFDENYAQGKG--YFIR--RTTSCHTNSIHTPENREK 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 167599440   93 TQQKSNLELLRISLLLIQSWLEPVQLLR----SVFANSLVYGASDSNVYRHLKDLEEGIQTLMW 152
Cdd:pfam00103  86 AQQTSNEELLKWSLMLLYSWLEPLYHLVtelsSMKEVSDTILSKAKDIEEKNKDLLEGIERIFS 149
 
Name Accession Description Interval E-value
somatotropin_like cd10285
Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; ...
 35-170 2.07e-47

Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; Growth hormone (GH) or somatotropin is a peptide hormone synthesized by the pituitary gland, which mediates anabolic effects in development. GH is known to activate, via binding to specific cellular receptors, the MAPK/ERK and JAK-STAT signaling pathways. Via the latter, it triggers the secretion of insulin-like growth factor 1 (mostly in the liver). Besides increasing body height, GH has been shown to have a host of other effects.


Pssm-ID: 198435  Cd Length: 180  Bit Score: 155.30  E-value: 2.07e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167599440  35 LFDNAMLRARRLYQLAYDTYQEFEEAYILKEQKYSFLQNPQtSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLE 114
Cdd:cd10285    1 LFSNAVLRAQHLHQLAADIYKDFERSYIPEEQRQSNKNSPA-AFCYSESIPAPTGKDETQQKSDLELLRISLLLIQSWLK 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 167599440 115 PVQLLRSVFANSLVyGASDSNVYRHLKDLEEGIQTLMWVRVAPGIPNPGAPLASRD 170
Cdd:cd10285   80 PVQFLSSVFTNQLH-FGSSDRIYEKLKDLEEGIQTLIRELEDGSPRGGQLLKQTYS 134
Hormone_1 pfam00103
Somatotropin hormone family;
22-152 4.55e-38

Somatotropin hormone family;


Pssm-ID: 306585  Cd Length: 214  Bit Score: 132.50  E-value: 4.55e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167599440   22 QEGSAFPT---------IPLSRLFDNAMLRARRLYQLAYDTYQEFEEAYILKEQkySFLQnpQTSLCFSESIPTPSNRVK 92
Cdd:pfam00103  10 ENVASCPScapdnvgcrMSLEDLFDNATLLSHNMYNLASDMFTEFDENYAQGKG--YFIR--RTTSCHTNSIHTPENREK 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 167599440   93 TQQKSNLELLRISLLLIQSWLEPVQLLR----SVFANSLVYGASDSNVYRHLKDLEEGIQTLMW 152
Cdd:pfam00103  86 AQQTSNEELLKWSLMLLYSWLEPLYHLVtelsSMKEVSDTILSKAKDIEEKNKDLLEGIERIFS 149
growth_hormone_like cd10284
Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes ...
 35-151 4.45e-36

Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes growth hormones 1 and 2, prolactin, prolactin 2, and other members that play vital roles in a variety of processes, including growth control. They are long-chain class-I helical cytokines, most of which are secreted by the pituitary gland, and are active as monomers, binding to cellular receptors with EpoR-like ligand binding domains.


Pssm-ID: 198434  Cd Length: 178  Bit Score: 126.46  E-value: 4.45e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167599440  35 LFDNAMLRARRLYQLAYDTYQEFEEAYILKEQKysflQNPQTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLIQSWLE 114
Cdd:cd10284    1 LFDRAIPHAERVYHLSSEAYAEFEEKYIPGENP----PNNVVMSCHTASIPTPSSKEEAQQKSDKELLRISLELLQSWSE 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 167599440 115 PVQLLRSVFAN----SLVYGASDSNVYRHLKDLEEGIQTLM 151
Cdd:cd10284   77 PLLHLHTVLANskgtSLALLPKAKQVSEMLKLLEDGVETLS 117
prolactin_like cd10288
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; ...
 30-151 1.05e-08

Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; Prolactin is primarily responsible for stimulating milk production and breast development in mammals. Aside from roles in reproduction, various functions have been attributed to prolactin, more than for other pituitary gland hormones combined. These are roles in growth and development, metamorphosis, metabolism of lipids, carbohydrates, and steroids, brain biochemistry and even immunoregulation, among others. Most of these roles are poorly understood, but it has become clear that many prolactin-like hormones are actually produced in the placenta and not the pituitary.


Pssm-ID: 198438  Cd Length: 199  Bit Score: 53.81  E-value: 1.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167599440  30 IPLSRLFDNAMLRARRLYQLAYDTYQEFEEAYIlkeQKYSFLQNPqTSLCFSESIPTPSNRVKTQQKSNLELLRISLLLI 109
Cdd:cd10288   13 LSLEDLFDRAVSLSHNIHNLSSEMFNEFDENYA---QGRGFVDRA-LTSCHTSSLTTPENKEQAQQIKNEDLLKLIISLL 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 167599440 110 QSWLEPVQLLRSVFANSLvyGASDSNVYRhLKDLEEGIQTLM 151
Cdd:cd10288   89 RSWNEPLKHLVTELSSMK--GAPDTILSK-AKEIEEKNKELL 127
somatolactin cd10286
Somatolactin (SL) and somatolactin-like proteins; This family of hormones specific to ...
 22-120 5.49e-07

Somatolactin (SL) and somatolactin-like proteins; This family of hormones specific to Actinopterygii is expressed in the pars intermedia bordering the neurohypophysis (posterior pituitary). Somatolactin appears to be involved in acid-base regulation, but much of its physiological role remains to be understood.


Pssm-ID: 198436  Cd Length: 207  Bit Score: 48.70  E-value: 5.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167599440  22 QEGSAFPTIPLSRLFDNAMLRARRLYQLAYDTYQEFEEAYIlkeqkYSFLQNPQTSL---CFSESIPTPSNRVKTQQKSN 98
Cdd:cd10286   10 DTGGRCCSISLEKLLDRAIQHAELIYRVSEESCTLFEEMFI-----PFSVRALLIQEgnaCSTKTVSIPTSKTEIQQISD 84

                         90       100
                 ....*....|....*....|..
gi 167599440  99 LELLRISLLLIQSWLEPVQLLR 120
Cdd:cd10286   85 KWLLHSVLILVQFWIDPLVDLQ 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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