interferon regulatory factor 4 isoform 1 [Homo sapiens]
interferon regulatory factor( domain architecture ID 10457095)
interferon regulatory factor (IRF) is a transcriptional regulator that is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
IRF-3 | pfam10401 | Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ... |
249-418 | 5.42e-88 | ||||
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection. : Pssm-ID: 463076 Cd Length: 180 Bit Score: 266.05 E-value: 5.42e-88
|
||||||||
IRF | pfam00605 | Interferon regulatory factor transcription factor; This family of transcription factors are ... |
23-128 | 8.48e-68 | ||||
Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA. : Pssm-ID: 459863 Cd Length: 106 Bit Score: 211.27 E-value: 8.48e-68
|
||||||||
Name | Accession | Description | Interval | E-value | ||||
IRF-3 | pfam10401 | Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ... |
249-418 | 5.42e-88 | ||||
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection. Pssm-ID: 463076 Cd Length: 180 Bit Score: 266.05 E-value: 5.42e-88
|
||||||||
IRF | pfam00605 | Interferon regulatory factor transcription factor; This family of transcription factors are ... |
23-128 | 8.48e-68 | ||||
Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA. Pssm-ID: 459863 Cd Length: 106 Bit Score: 211.27 E-value: 8.48e-68
|
||||||||
IRF | smart00348 | interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ... |
23-130 | 1.17e-53 | ||||
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat Pssm-ID: 128642 Cd Length: 107 Bit Score: 174.83 E-value: 1.17e-53
|
||||||||
IRF | cd00103 | Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ... |
24-129 | 3.09e-46 | ||||
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation. Pssm-ID: 238051 Cd Length: 107 Bit Score: 155.53 E-value: 3.09e-46
|
||||||||
Name | Accession | Description | Interval | E-value | ||||
IRF-3 | pfam10401 | Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ... |
249-418 | 5.42e-88 | ||||
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection. Pssm-ID: 463076 Cd Length: 180 Bit Score: 266.05 E-value: 5.42e-88
|
||||||||
IRF | pfam00605 | Interferon regulatory factor transcription factor; This family of transcription factors are ... |
23-128 | 8.48e-68 | ||||
Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA. Pssm-ID: 459863 Cd Length: 106 Bit Score: 211.27 E-value: 8.48e-68
|
||||||||
IRF | smart00348 | interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ... |
23-130 | 1.17e-53 | ||||
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat Pssm-ID: 128642 Cd Length: 107 Bit Score: 174.83 E-value: 1.17e-53
|
||||||||
IRF | cd00103 | Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ... |
24-129 | 3.09e-46 | ||||
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation. Pssm-ID: 238051 Cd Length: 107 Bit Score: 155.53 E-value: 3.09e-46
|
||||||||
Blast search parameters | ||||
|