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Conserved domains on  [gi|1675216962|gb|TMS10450|]
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Krueppel-like factor 10 [Larimichthys crocea]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 19-366 1.60e-104

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


:

Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 311.15  E-value: 1.60e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962  19 LGAGDMEAVEALVSMTKHWKTHSFKLRHSRPLTPSSDCSEDDSVPIGTTVLQDSPLCMTPPYSPPHLEATHPPvhQPAAA 98
Cdd:cd21572     1 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDDDLPSPADFHDSPPFCMTPPYSPPHFEATHPP--SAATL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962  99 GSPSRQPTEEACLHTHTAASQQRFLCTSVIRHTSDGQRSSCDVHPvsredrftqvhtkdsktdlssedglngrhserniv 178
Cdd:cd21572    79 HPPAAQPPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCP----------------------------------- 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962 179 ikcdsnaatalqpvsvtlpnvvetsqiqlspglddksNTPQAVSSLPAGGPGVSPISVFCQILPVSSPSTTVVQNPVTAS 258
Cdd:cd21572   124 -------------------------------------SSPSVVPSVPAGVAGVSPVPVYCQILPVSSSSTTVVAAQAPLP 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962 259 ESQGQqrlpissaltavhtqlqqqqqalpqtqtqAASPAQVFLFGGQVAKGPVMFLVPQPAVPTVYIQPALVTPSGTKLP 338
Cdd:cd21572   167 QPQQQ-----------------------------AASPAQVFLMGGQVPKGPVMFLVPQPVVPTLYVQPTLVTPGGTKLA 217

                         330       340
                  ....*....|....*....|....*...
gi 1675216962 339 AIAPAPGPTLLEQRQSPLQPEVSRTRSH 366
Cdd:cd21572   218 AIAPAPGHTPSEQRKSPPQPEVSRVRSH 245
zf-H2C2_2 pfam13465
Zinc-finger double domain;
382-409 5.51e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 5.51e-05
                          10        20
                  ....*....|....*....|....*...
gi 1675216962 382 HLKAHMRTHTGEKPFKCkwDGCERRFAR 409
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
342-448 3.82e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 3.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962 342 PAPGPTLLEQRQSPLQPEVS--RTRSHVCPHEDCNKTYFKSSHLKAHMRT--HTGE--KPFKCKWDGCERRFARSDELSR 415
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSSseKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKR 341

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1675216962 416 HRRTHTGEKKFACPM--CLSRFMRSDHLAKHARRH 448
Cdd:COG5048   342 HILLHTSISPAKEKLlnSSSKFSPLLNNEPPQSLQ 376
 
Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 19-366 1.60e-104

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 311.15  E-value: 1.60e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962  19 LGAGDMEAVEALVSMTKHWKTHSFKLRHSRPLTPSSDCSEDDSVPIGTTVLQDSPLCMTPPYSPPHLEATHPPvhQPAAA 98
Cdd:cd21572     1 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDDDLPSPADFHDSPPFCMTPPYSPPHFEATHPP--SAATL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962  99 GSPSRQPTEEACLHTHTAASQQRFLCTSVIRHTSDGQRSSCDVHPvsredrftqvhtkdsktdlssedglngrhserniv 178
Cdd:cd21572    79 HPPAAQPPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCP----------------------------------- 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962 179 ikcdsnaatalqpvsvtlpnvvetsqiqlspglddksNTPQAVSSLPAGGPGVSPISVFCQILPVSSPSTTVVQNPVTAS 258
Cdd:cd21572   124 -------------------------------------SSPSVVPSVPAGVAGVSPVPVYCQILPVSSSSTTVVAAQAPLP 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962 259 ESQGQqrlpissaltavhtqlqqqqqalpqtqtqAASPAQVFLFGGQVAKGPVMFLVPQPAVPTVYIQPALVTPSGTKLP 338
Cdd:cd21572   167 QPQQQ-----------------------------AASPAQVFLMGGQVPKGPVMFLVPQPVVPTLYVQPTLVTPGGTKLA 217

                         330       340
                  ....*....|....*....|....*...
gi 1675216962 339 AIAPAPGPTLLEQRQSPLQPEVSRTRSH 366
Cdd:cd21572   218 AIAPAPGHTPSEQRKSPPQPEVSRVRSH 245
zf-H2C2_2 pfam13465
Zinc-finger double domain;
382-409 5.51e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 5.51e-05
                          10        20
                  ....*....|....*....|....*...
gi 1675216962 382 HLKAHMRTHTGEKPFKCkwDGCERRFAR 409
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
348-421 9.39e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 9.39e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1675216962 348 LLEQRQSPLQPEVSRTRSHVCPheDCNKTYFKSSHLKAHMRTHTGEKPFKCKWDGCERRFARSDELSRHRRTHT 421
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
342-448 3.82e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 3.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962 342 PAPGPTLLEQRQSPLQPEVS--RTRSHVCPHEDCNKTYFKSSHLKAHMRT--HTGE--KPFKCKWDGCERRFARSDELSR 415
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSSseKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKR 341

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1675216962 416 HRRTHTGEKKFACPM--CLSRFMRSDHLAKHARRH 448
Cdd:COG5048   342 HILLHTSISPAKEKLlnSSSKFSPLLNNEPPQSLQ 376
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 366-390 2.28e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.28e-03
                          10        20
                  ....*....|....*....|....*
gi 1675216962 366 HVCPHedCNKTYFKSSHLKAHMRTH 390
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 19-366 1.60e-104

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 311.15  E-value: 1.60e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962  19 LGAGDMEAVEALVSMTKHWKTHSFKLRHSRPLTPSSDCSEDDSVPIGTTVLQDSPLCMTPPYSPPHLEATHPPvhQPAAA 98
Cdd:cd21572     1 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDDDLPSPADFHDSPPFCMTPPYSPPHFEATHPP--SAATL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962  99 GSPSRQPTEEACLHTHTAASQQRFLCTSVIRHTSDGQRSSCDVHPvsredrftqvhtkdsktdlssedglngrhserniv 178
Cdd:cd21572    79 HPPAAQPPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCP----------------------------------- 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962 179 ikcdsnaatalqpvsvtlpnvvetsqiqlspglddksNTPQAVSSLPAGGPGVSPISVFCQILPVSSPSTTVVQNPVTAS 258
Cdd:cd21572   124 -------------------------------------SSPSVVPSVPAGVAGVSPVPVYCQILPVSSSSTTVVAAQAPLP 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962 259 ESQGQqrlpissaltavhtqlqqqqqalpqtqtqAASPAQVFLFGGQVAKGPVMFLVPQPAVPTVYIQPALVTPSGTKLP 338
Cdd:cd21572   167 QPQQQ-----------------------------AASPAQVFLMGGQVPKGPVMFLVPQPVVPTLYVQPTLVTPGGTKLA 217

                         330       340
                  ....*....|....*....|....*...
gi 1675216962 339 AIAPAPGPTLLEQRQSPLQPEVSRTRSH 366
Cdd:cd21572   218 AIAPAPGHTPSEQRKSPPQPEVSRVRSH 245
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 20-366 1.16e-81

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 251.78  E-value: 1.16e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962  20 GAGDMEAVEALVSMTKHWKTHSFKLRHSRPLTPSSDCSEDDSVPIGTTVLQD-SPLCMTPPYSPPHLEATHPPVHQPAAA 98
Cdd:cd21974     1 EQGDLEAVEALVSMSSWWKRRQKRLRKPRPLTPSSDSSDEDDAPESPKDFHSlSSLCMTPPYSPPFFEASHSPSVASLHP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962  99 GS-PSRQPTEEACLHTHTAASQQRFLCTSVIRHTSDgqrsscdvhpvsredrftqvhtkdsktdlssedglngrhserni 177
Cdd:cd21974    81 PSaASSQPPPEPESSEPPAASPQRAQATSVIRHTAD-------------------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962 178 vikcdsnaatalqpvsvtlpnvvetsqiqlspglddksntpqavsslpagGPGVSPISVFCQILPVSSPSTTVVQNPVTA 257
Cdd:cd21974   117 --------------------------------------------------PVPVSPPPVLCQMLPVSSSSGVIVAFLKAP 146

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962 258 SESQGQQRLPIssaltavhtqlqqqqqalpqtqtqaASPAQVFLFGGQVAKGPVMFLVPQPAVPTVYIQPALVTPSGTKL 337
Cdd:cd21974   147 QQPSPQPQKPA-------------------------LPQPQVVLVGGQVPQGPVMLVVPQPAVPQPYVQPTVVTPGGTKL 201

                         330       340
                  ....*....|....*....|....*....
gi 1675216962 338 PAIAPAPGPTLLEQRqSPLQPEVSRTRSH 366
Cdd:cd21974   202 LPIAPAPGFIPSGQS-SAPQPDFSRRRNH 229
KLF11_N cd21584
N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as ...
 23-344 1.10e-13

N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as Krueppel-like factor 11; Fetal Kruppel-like factor-1/FKLF-1; maturity-onset diabetes of the young 7/MODY7; TGFbeta Inducible Early Growth Response 2/TIEG2) is a protein that in humans is encoded by the KLF11 gene. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF11 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF11.


Pssm-ID: 409242 [Multi-domain]  Cd Length: 217  Bit Score: 70.02  E-value: 1.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962  23 DMEAVEALVSMTKhWKTHSFK--LRHSRPLTPSSDCseDDSV---PIGTTVLQD----SPLCMTPPYSPPHLEAThppvh 93
Cdd:cd21584     5 DLEAVEALVCMSS-WGQRSQKgdLLKIRPLTPASDS--CDSLtlhPAAPELPKDfhslSSLCMTPPHSPSFAEPS----- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962  94 qPAAAGSPSRQpteeaclhthtaasqqrfLCTSVIRHTSDgqrsscdvhpvsredrftqvhtkdsktdlssedglngrhs 173
Cdd:cd21584    77 -TTAPPPPCRA------------------MATSVIRHTAD---------------------------------------- 97

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962 174 ernivikcdsnaatalqpvsvtlpnvvetsqiqlspglddkSNTPQAVSSLPaggpgvspisVFCQILPVSSPSTTV--- 250
Cdd:cd21584    98 -----------------------------------------SSPPVPVPSPP----------VLCQMIPVSGQSGMIsaf 126

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962 251 VQNPVTASESQGqqrlPIssaltavhtqlqqqqqalpqtQTQAASPAQVFLFGGQVAKGPVMFLVPQPAVP-TVYIQPAL 329
Cdd:cd21584   127 LQPPALSAGTVK----PI---------------------LPQTAPASQPLLVGSPVPQGTVMLVLPQASVPqPPQCPQTV 181

                         330
                  ....*....|....*
gi 1675216962 330 VTPSGTKLPAIAPAP 344
Cdd:cd21584   182 MTLGNTKLLPLAPAP 196
zf-H2C2_2 pfam13465
Zinc-finger double domain;
382-409 5.51e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 5.51e-05
                          10        20
                  ....*....|....*....|....*...
gi 1675216962 382 HLKAHMRTHTGEKPFKCkwDGCERRFAR 409
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
348-421 9.39e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 9.39e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1675216962 348 LLEQRQSPLQPEVSRTRSHVCPheDCNKTYFKSSHLKAHMRTHTGEKPFKCKWDGCERRFARSDELSRHRRTHT 421
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
342-448 3.82e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 3.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962 342 PAPGPTLLEQRQSPLQPEVS--RTRSHVCPHEDCNKTYFKSSHLKAHMRT--HTGE--KPFKCKWDGCERRFARSDELSR 415
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSSseKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKR 341

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1675216962 416 HRRTHTGEKKFACPM--CLSRFMRSDHLAKHARRH 448
Cdd:COG5048   342 HILLHTSISPAKEKLlnSSSKFSPLLNNEPPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
364-449 6.38e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 6.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675216962 364 RSHVCPHEDCNKTYFKSSHLKAHMRTHTGEKPFKCKWDGCERRF-----ARSDELSRHRRTHTGEKKFACPM--CLSRFM 436
Cdd:COG5048   320 KPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETLSnsCIRNFK 399

                          90
                  ....*....|...
gi 1675216962 437 RSDHLAKHARRHL 449
Cdd:COG5048   400 RDSNLSLHIITHL 412
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 366-390 2.28e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.28e-03
                          10        20
                  ....*....|....*....|....*
gi 1675216962 366 HVCPHedCNKTYFKSSHLKAHMRTH 390
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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