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Conserved domains on  [gi|1675206820|gb|QCT73198|]
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trimethylamine methyltransferase [Eubacterium maltosivorans]

Protein Classification

trimethylamine methyltransferase family protein( domain architecture ID 10009465)

trimethylamine methyltransferase family protein similar to Desulfitobacterium hafniense glycine betaine methyltransferase that likely methylates a corrinoid protein, likely the adjacently encoded DSY3155, with glycine betaine, to then supply methyl groups to tetrahydrofolate for ultimate conversion to carbon dioxide

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MttB2 COG5598
Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];
8-481 7.42e-170

Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];


:

Pssm-ID: 444334  Cd Length: 469  Bit Score: 486.59  E-value: 7.42e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820   8 YENYISTRDVELLHEYTLKVLKEVGVSFNCEEALDIFKNHGATVEGSIVKFDESLLNAALETVPKTFTIHTCSGE--TPI 85
Cdd:COG5598     2 RYEPLSEEQIERIHEAALRILEEIGVEFEHEEALEIFKKAGARVEGGRVRIPRALVEEALATAPSSFTLYARNPErdVEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820  86 GEPfRPKTVGCYGPSKFL-FEDDTYRVAQMADMIKFLKLMDTSDVTDFVNNAAFDTPDLDksQDDFYLPQVAMCLKYSKK 164
Cdd:COG5598    82 GGG-NVVFGPGGGAPFVLdLETGERRPATLEDLANFAKLADALPNIDFSGGNPVEPSDVP--VEVRHLDMLYAMLKYTDK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820 165 PTYGNVANslntrgkslKEAARGIANLYKEFYD----IWDKPVLLTNACALSPLGYSYEVLDNIIGLCEEGQPVTIITCS 240
Cdd:COG5598   159 PIMGSATG---------RERVEDSIEMARIVAGgeeeLREKPVVITLINPNSPLRFDEEMLEALIAYARAGQPVIITPFG 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820 241 MTNMTAPAALLGTVIQNNATILAGIVLTQLINPGVPVIYGSVSSATDMREVALAIGAPEAQLIQMSSLALARYYQIPVRV 320
Cdd:COG5598   230 LAGATAPVTLAGALAQQNAEALAGLVLAQLIRPGAPVIYGTFSSSMDMRTGAPAFGTPEAALLSAAAAQLARYYGLPSRS 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820 321 GVAGTDAMKPDYQAGVETFMNLMTTYLGKADFILHHAGILQSYALGSYEKFVLDEEVNRIMLRLNKGIDISD-TKAekvF 399
Cdd:COG5598   310 GGGLTDSKLPDAQAGYESAMSLLAAALAGANLILHAAGWLESGLTASYEKFVLDNEIIGMVRRLLRGIEVDEeTLA---L 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820 400 EQIKKAGPLGNYL-SGRTPKEYRQEHYLTKLFNR-------AAGEPNAifenigelRERAVKEIDERVAGYTLPDLTQTQ 471
Cdd:COG5598   387 DAIKEVGPGGHFLgHPHTLKHYRTEFYYPKLSDRenyeqweEAGSKDL--------LERANEKVKEILAEYEPPPLDPEI 458

                         490
                  ....*....|
gi 1675206820 472 KQILNKFLPE 481
Cdd:COG5598   459 DEELDAYIAR 468
 
Name Accession Description Interval E-value
MttB2 COG5598
Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];
8-481 7.42e-170

Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];


Pssm-ID: 444334  Cd Length: 469  Bit Score: 486.59  E-value: 7.42e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820   8 YENYISTRDVELLHEYTLKVLKEVGVSFNCEEALDIFKNHGATVEGSIVKFDESLLNAALETVPKTFTIHTCSGE--TPI 85
Cdd:COG5598     2 RYEPLSEEQIERIHEAALRILEEIGVEFEHEEALEIFKKAGARVEGGRVRIPRALVEEALATAPSSFTLYARNPErdVEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820  86 GEPfRPKTVGCYGPSKFL-FEDDTYRVAQMADMIKFLKLMDTSDVTDFVNNAAFDTPDLDksQDDFYLPQVAMCLKYSKK 164
Cdd:COG5598    82 GGG-NVVFGPGGGAPFVLdLETGERRPATLEDLANFAKLADALPNIDFSGGNPVEPSDVP--VEVRHLDMLYAMLKYTDK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820 165 PTYGNVANslntrgkslKEAARGIANLYKEFYD----IWDKPVLLTNACALSPLGYSYEVLDNIIGLCEEGQPVTIITCS 240
Cdd:COG5598   159 PIMGSATG---------RERVEDSIEMARIVAGgeeeLREKPVVITLINPNSPLRFDEEMLEALIAYARAGQPVIITPFG 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820 241 MTNMTAPAALLGTVIQNNATILAGIVLTQLINPGVPVIYGSVSSATDMREVALAIGAPEAQLIQMSSLALARYYQIPVRV 320
Cdd:COG5598   230 LAGATAPVTLAGALAQQNAEALAGLVLAQLIRPGAPVIYGTFSSSMDMRTGAPAFGTPEAALLSAAAAQLARYYGLPSRS 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820 321 GVAGTDAMKPDYQAGVETFMNLMTTYLGKADFILHHAGILQSYALGSYEKFVLDEEVNRIMLRLNKGIDISD-TKAekvF 399
Cdd:COG5598   310 GGGLTDSKLPDAQAGYESAMSLLAAALAGANLILHAAGWLESGLTASYEKFVLDNEIIGMVRRLLRGIEVDEeTLA---L 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820 400 EQIKKAGPLGNYL-SGRTPKEYRQEHYLTKLFNR-------AAGEPNAifenigelRERAVKEIDERVAGYTLPDLTQTQ 471
Cdd:COG5598   387 DAIKEVGPGGHFLgHPHTLKHYRTEFYYPKLSDRenyeqweEAGSKDL--------LERANEKVKEILAEYEPPPLDPEI 458

                         490
                  ....*....|
gi 1675206820 472 KQILNKFLPE 481
Cdd:COG5598   459 DEELDAYIAR 468
MTTB pfam06253
Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine ...
 17-467 1.71e-75

Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.


Pssm-ID: 428852  Cd Length: 502  Bit Score: 245.65  E-value: 1.71e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820  17 VELLHEYTLKVLKEVGVSFNCEEALDIFKNHGATVEGSIVKFDESLLNAALETVPKTFTIHTcsgetpiGEPFRPKTVG- 95
Cdd:pfam06253  39 IAAIEEAAMRILEEIGIEFRDPEALELWRAAGADVDGERVRFDRGLVRELLATAPRQFTLHA-------RNPERDVVIGg 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820  96 -------CYGPSkFLFE-DDTYRVAQMADMIKFLKLMDTSDVTDFVNNAAFDTPDLDKSQDDFYLpqVAMCLKYSKKPTY 167
Cdd:pfam06253 112 nnlvfapVYGPP-FVRDlDRGRRYGTLADFRNFVKLTQMFPWLHHSGGTVVEPVDVPVNKRHLDM--LYAHLTLSDKPFM 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820 168 G------NVANSLNtrgksLKEAARGIanlykEFYDIWDKPVLLTNACALSPLGYSYEVLDNIIGLCEEGQPVTIITCSM 241
Cdd:pfam06253 189 GsvtgpeRAEDSIE-----MCRILFGL-----SFAEFRANPVMTTNINVNSPLTFDETMLGGLRVYARAGQAVIVTPFIL 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820 242 TNMTAPAALLGTVIQNNATILAGIVLTQLINPGVPVIYGSVSSATDMREVALAIGAPEAQLIQMSSLALARYYQIPVRVG 321
Cdd:pfam06253 259 AGAMAPVTVAGALAQSLAEALAGIALTQLVRPGAPVIYGTFTSNVDMKSGAPTFGTPEPALATYVAGQLARRYGLPWRSS 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820 322 VAGTDAMKPDYQAGVETFMNLMTTYLGKADFILHHAGILQSYALGSYEKFVLDEEVNRIMLRLNKGIDISDtkAEKVFEQ 401
Cdd:pfam06253 339 GGLTASKIPDAQAAYESAMSLWAALLAGANFVLHAAGWLEGGLTASYEKFVMDADMLGMIHRLLAGIDVSD--DALAMDA 416

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1675206820 402 IKKAGPLGNYL-SGRTPKEYRQEHYLTKLFNRAAGEpnaIFENIGELR--ERAVKEIDERVAGYTLPDL 467
Cdd:pfam06253 417 IREVGPGGHFLgCAHTQARYETAFYRPELSDWRNFE---TWEEEGAKDtaERANRRWKKILAEYEAPPL 482
 
Name Accession Description Interval E-value
MttB2 COG5598
Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];
8-481 7.42e-170

Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];


Pssm-ID: 444334  Cd Length: 469  Bit Score: 486.59  E-value: 7.42e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820   8 YENYISTRDVELLHEYTLKVLKEVGVSFNCEEALDIFKNHGATVEGSIVKFDESLLNAALETVPKTFTIHTCSGE--TPI 85
Cdd:COG5598     2 RYEPLSEEQIERIHEAALRILEEIGVEFEHEEALEIFKKAGARVEGGRVRIPRALVEEALATAPSSFTLYARNPErdVEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820  86 GEPfRPKTVGCYGPSKFL-FEDDTYRVAQMADMIKFLKLMDTSDVTDFVNNAAFDTPDLDksQDDFYLPQVAMCLKYSKK 164
Cdd:COG5598    82 GGG-NVVFGPGGGAPFVLdLETGERRPATLEDLANFAKLADALPNIDFSGGNPVEPSDVP--VEVRHLDMLYAMLKYTDK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820 165 PTYGNVANslntrgkslKEAARGIANLYKEFYD----IWDKPVLLTNACALSPLGYSYEVLDNIIGLCEEGQPVTIITCS 240
Cdd:COG5598   159 PIMGSATG---------RERVEDSIEMARIVAGgeeeLREKPVVITLINPNSPLRFDEEMLEALIAYARAGQPVIITPFG 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820 241 MTNMTAPAALLGTVIQNNATILAGIVLTQLINPGVPVIYGSVSSATDMREVALAIGAPEAQLIQMSSLALARYYQIPVRV 320
Cdd:COG5598   230 LAGATAPVTLAGALAQQNAEALAGLVLAQLIRPGAPVIYGTFSSSMDMRTGAPAFGTPEAALLSAAAAQLARYYGLPSRS 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820 321 GVAGTDAMKPDYQAGVETFMNLMTTYLGKADFILHHAGILQSYALGSYEKFVLDEEVNRIMLRLNKGIDISD-TKAekvF 399
Cdd:COG5598   310 GGGLTDSKLPDAQAGYESAMSLLAAALAGANLILHAAGWLESGLTASYEKFVLDNEIIGMVRRLLRGIEVDEeTLA---L 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820 400 EQIKKAGPLGNYL-SGRTPKEYRQEHYLTKLFNR-------AAGEPNAifenigelRERAVKEIDERVAGYTLPDLTQTQ 471
Cdd:COG5598   387 DAIKEVGPGGHFLgHPHTLKHYRTEFYYPKLSDRenyeqweEAGSKDL--------LERANEKVKEILAEYEPPPLDPEI 458

                         490
                  ....*....|
gi 1675206820 472 KQILNKFLPE 481
Cdd:COG5598   459 DEELDAYIAR 468
MTTB pfam06253
Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine ...
 17-467 1.71e-75

Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.


Pssm-ID: 428852  Cd Length: 502  Bit Score: 245.65  E-value: 1.71e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820  17 VELLHEYTLKVLKEVGVSFNCEEALDIFKNHGATVEGSIVKFDESLLNAALETVPKTFTIHTcsgetpiGEPFRPKTVG- 95
Cdd:pfam06253  39 IAAIEEAAMRILEEIGIEFRDPEALELWRAAGADVDGERVRFDRGLVRELLATAPRQFTLHA-------RNPERDVVIGg 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820  96 -------CYGPSkFLFE-DDTYRVAQMADMIKFLKLMDTSDVTDFVNNAAFDTPDLDKSQDDFYLpqVAMCLKYSKKPTY 167
Cdd:pfam06253 112 nnlvfapVYGPP-FVRDlDRGRRYGTLADFRNFVKLTQMFPWLHHSGGTVVEPVDVPVNKRHLDM--LYAHLTLSDKPFM 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820 168 G------NVANSLNtrgksLKEAARGIanlykEFYDIWDKPVLLTNACALSPLGYSYEVLDNIIGLCEEGQPVTIITCSM 241
Cdd:pfam06253 189 GsvtgpeRAEDSIE-----MCRILFGL-----SFAEFRANPVMTTNINVNSPLTFDETMLGGLRVYARAGQAVIVTPFIL 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820 242 TNMTAPAALLGTVIQNNATILAGIVLTQLINPGVPVIYGSVSSATDMREVALAIGAPEAQLIQMSSLALARYYQIPVRVG 321
Cdd:pfam06253 259 AGAMAPVTVAGALAQSLAEALAGIALTQLVRPGAPVIYGTFTSNVDMKSGAPTFGTPEPALATYVAGQLARRYGLPWRSS 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675206820 322 VAGTDAMKPDYQAGVETFMNLMTTYLGKADFILHHAGILQSYALGSYEKFVLDEEVNRIMLRLNKGIDISDtkAEKVFEQ 401
Cdd:pfam06253 339 GGLTASKIPDAQAAYESAMSLWAALLAGANFVLHAAGWLEGGLTASYEKFVMDADMLGMIHRLLAGIDVSD--DALAMDA 416

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1675206820 402 IKKAGPLGNYL-SGRTPKEYRQEHYLTKLFNRAAGEpnaIFENIGELR--ERAVKEIDERVAGYTLPDL 467
Cdd:pfam06253 417 IREVGPGGHFLgCAHTQARYETAFYRPELSDWRNFE---TWEEEGAKDtaERANRRWKKILAEYEAPPL 482
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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