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Conserved domains on  [gi|1675110109|ref|WP_138624064|]
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NAD(P)/FAD-dependent oxidoreductase [Colwellia ponticola]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 11458465)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
1-417 0e+00

Predicted flavin-containing amine oxidase [General function prediction only];


:

Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 699.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109   1 MKHFAIIGSGISGLTAAYLLAKKHKVTVFEKNDCIGGHTATVDIEKAGEKHAIDTGFIVFNNKTYPNFLALLDEIGIGKI 80
Cdd:COG2907     3 RMRIAVIGSGISGLTAAWLLSRRHDVTLFEANDRLGGHTHTVDVDLDGRTVPVDTGFIVFNERTYPNLTALFAELGVPTQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109  81 PTEMSFSVHNCQSGMEYNGHNLDTLFAQRRNIFKPKFWLLVKEILRFNKLCKSIYAQQQYiEGLTLGEFLTAHHFSDFFA 160
Cdd:COG2907    83 PSDMSFSVSLDGGGLEYAGSNLNGLFAQRRNLLRPRFWRMLRDILRFNREAPALLEAGSD-DDLTLGEFLDRNGYSEAFR 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 161 EHYILPMGAAIWSSSLAQMEDFEFTFFVRFFHNHGLLNIADRPQWYVIPQGSRSYLAPLCQPFKDNIHLNANISGITRHD 240
Cdd:COG2907   162 DHYLLPMGAAIWSCPPDDMLDFPARFFVRFFHNHGLLSVTDRPQWRTVKGGSREYVRRLTAGLKDRIRLNTPVRSVRRDA 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 241 NKVQLHFTDSPSQTFDEVVIACHSDQALALLEDASDDEKSVLSAMPYSANSVILHTDKKLLPKRKKAWASWNYQLSQ-DR 319
Cdd:COG2907   242 DGVEVRTADGEEERFDHVVFATHSDQALALLADPTPAERELLGAIRYQPNEAVLHTDTSLMPRRRRAWASWNYLLDReDG 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 320 SKPASVTYNMNILQNIDSKHTFCVTLNQKAAIDPKEILREFTYHHPVFSTQSIKAQQQRPLICGHNHTHFAGAYWHSGFH 399
Cdd:COG2907   322 TRPVSVTYWMNRLQGLPAPTPVFVTLNPTRPIDPEKVLARFTYEHPVFDLAAIAAQKRLPELQGRNRTWFCGAYWGYGFH 401

                         410
                  ....*....|....*...
gi 1675110109 400 EDGVRSAVEVAQRFDCHL 417
Cdd:COG2907   402 EDGLRSALRVAEALGARL 419
 
Name Accession Description Interval E-value
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
1-417 0e+00

Predicted flavin-containing amine oxidase [General function prediction only];


Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 699.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109   1 MKHFAIIGSGISGLTAAYLLAKKHKVTVFEKNDCIGGHTATVDIEKAGEKHAIDTGFIVFNNKTYPNFLALLDEIGIGKI 80
Cdd:COG2907     3 RMRIAVIGSGISGLTAAWLLSRRHDVTLFEANDRLGGHTHTVDVDLDGRTVPVDTGFIVFNERTYPNLTALFAELGVPTQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109  81 PTEMSFSVHNCQSGMEYNGHNLDTLFAQRRNIFKPKFWLLVKEILRFNKLCKSIYAQQQYiEGLTLGEFLTAHHFSDFFA 160
Cdd:COG2907    83 PSDMSFSVSLDGGGLEYAGSNLNGLFAQRRNLLRPRFWRMLRDILRFNREAPALLEAGSD-DDLTLGEFLDRNGYSEAFR 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 161 EHYILPMGAAIWSSSLAQMEDFEFTFFVRFFHNHGLLNIADRPQWYVIPQGSRSYLAPLCQPFKDNIHLNANISGITRHD 240
Cdd:COG2907   162 DHYLLPMGAAIWSCPPDDMLDFPARFFVRFFHNHGLLSVTDRPQWRTVKGGSREYVRRLTAGLKDRIRLNTPVRSVRRDA 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 241 NKVQLHFTDSPSQTFDEVVIACHSDQALALLEDASDDEKSVLSAMPYSANSVILHTDKKLLPKRKKAWASWNYQLSQ-DR 319
Cdd:COG2907   242 DGVEVRTADGEEERFDHVVFATHSDQALALLADPTPAERELLGAIRYQPNEAVLHTDTSLMPRRRRAWASWNYLLDReDG 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 320 SKPASVTYNMNILQNIDSKHTFCVTLNQKAAIDPKEILREFTYHHPVFSTQSIKAQQQRPLICGHNHTHFAGAYWHSGFH 399
Cdd:COG2907   322 TRPVSVTYWMNRLQGLPAPTPVFVTLNPTRPIDPEKVLARFTYEHPVFDLAAIAAQKRLPELQGRNRTWFCGAYWGYGFH 401

                         410
                  ....*....|....*...
gi 1675110109 400 EDGVRSAVEVAQRFDCHL 417
Cdd:COG2907   402 EDGLRSALRVAEALGARL 419
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 11-412 7.26e-23

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 100.26  E-value: 7.26e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109  11 ISGLTAAYLLAKK-HKVTVFEKNDCIGGHTATVdiEKAGEKhaIDTGFIVFNNkTYPNFLALLDEIGIgkiPTEMSFSVH 89
Cdd:pfam01593   1 LAGLAAARELLRAgHDVTVLEARDRVGGRIRTV--RDDGFL--IELGAMWFHG-AQPPLLALLKELGL---EDRLVLPDP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109  90 NCQSGM-EYNGHNLDTLFAQRRNIFkPKFWLLVKEILRFNKLCKSIYAQQQYIEG---------LTLGEFLTAHHFSDFF 159
Cdd:pfam01593  73 APFYTVlFAGGRRYPGDFRRVPAGW-EGLLEFGRLLSIPEKLRLGLAALASDALDefdlddfslAESLLFLGRRGPGDVE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 160 A-EHYILPMGAAIWSSSLAQMEDFEFTFFVRFFHNHGL-LNIADRPQWyVIPQGSRSYLAPLCQPF-KDNIHLNANISGI 236
Cdd:pfam01593 152 VwDRLIDPELFAALPFASGAFAGDPSELSAGLALPLLWaLLGEGGSLL-LPRGGLGALPDALAAQLlGGDVRLNTRVRSI 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 237 TRHDNKVQLHFTDSPSQTFDEVVIACHSD--QALALLEDASDDEKSVLSAMPY-SANSVILHTDKKLLPKRKKAWASwnY 313
Cdd:pfam01593 231 DREGDGVTVTLTDGEVIEADAVIVTVPLGvlKRILFTPPLPPEKARAIRNLGYgPVNKVHLEFDRKFWPDLGLLGLL--S 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 314 QLSQDRSKPA-SVTYNMnilQNIDSKHTFCVTL-------NQKAAIDPKEILREFT----------------YHHPVFST 369
Cdd:pfam01593 309 ELLTGLGTAFsWLTFPN---RAPPGKGLLLLVYvgpgdraRELEGLSDEELLQAVLrdlrklfgeeapeplrVLVSDWHT 385

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1675110109 370 QSI-----KAQQQRPlicGHNHT-----------HFAGAYWHSGFH---EDGVRSAVEVAQR 412
Cdd:pfam01593 386 DPWprgsySLPQYGP---GHDDYrplartpdpglFFAGEHTSTGYPgtvEGAIESGRRAARA 444
PRK07233 PRK07233
hypothetical protein; Provisional
 3-127 8.48e-14

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 72.61  E-value: 8.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109   3 HFAIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGGHTATVDIekAG---EK--HAIdtgfivFNNKTYpnFLALLDEIG 76
Cdd:PRK07233    1 KIAIVGGGIAGLAAAYRLAKRgHEVTVFEADDQLGGLAASFEF--GGlpiERfyHHI------FKSDEA--LLELLDELG 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1675110109  77 IGK----IPTEMsfsvhncqsGMEYNG--HNLDTLFaqrrnifkpkfwllvkEILRF 127
Cdd:PRK07233   71 LEDklrwRETKT---------GYYVDGklYPLGTPL----------------ELLRF 102
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 1-43 8.43e-08

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 54.07  E-value: 8.43e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1675110109   1 MKHFAIIGSGISGLTAAYLLAKKHK-----VTVFEKNDCIGGHTATVD 43
Cdd:TIGR00562   2 KKHVVIIGGGISGLCAAYYLEKEIPelpveLTLVEASDRVGGKIQTVK 49
 
Name Accession Description Interval E-value
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
1-417 0e+00

Predicted flavin-containing amine oxidase [General function prediction only];


Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 699.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109   1 MKHFAIIGSGISGLTAAYLLAKKHKVTVFEKNDCIGGHTATVDIEKAGEKHAIDTGFIVFNNKTYPNFLALLDEIGIGKI 80
Cdd:COG2907     3 RMRIAVIGSGISGLTAAWLLSRRHDVTLFEANDRLGGHTHTVDVDLDGRTVPVDTGFIVFNERTYPNLTALFAELGVPTQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109  81 PTEMSFSVHNCQSGMEYNGHNLDTLFAQRRNIFKPKFWLLVKEILRFNKLCKSIYAQQQYiEGLTLGEFLTAHHFSDFFA 160
Cdd:COG2907    83 PSDMSFSVSLDGGGLEYAGSNLNGLFAQRRNLLRPRFWRMLRDILRFNREAPALLEAGSD-DDLTLGEFLDRNGYSEAFR 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 161 EHYILPMGAAIWSSSLAQMEDFEFTFFVRFFHNHGLLNIADRPQWYVIPQGSRSYLAPLCQPFKDNIHLNANISGITRHD 240
Cdd:COG2907   162 DHYLLPMGAAIWSCPPDDMLDFPARFFVRFFHNHGLLSVTDRPQWRTVKGGSREYVRRLTAGLKDRIRLNTPVRSVRRDA 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 241 NKVQLHFTDSPSQTFDEVVIACHSDQALALLEDASDDEKSVLSAMPYSANSVILHTDKKLLPKRKKAWASWNYQLSQ-DR 319
Cdd:COG2907   242 DGVEVRTADGEEERFDHVVFATHSDQALALLADPTPAERELLGAIRYQPNEAVLHTDTSLMPRRRRAWASWNYLLDReDG 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 320 SKPASVTYNMNILQNIDSKHTFCVTLNQKAAIDPKEILREFTYHHPVFSTQSIKAQQQRPLICGHNHTHFAGAYWHSGFH 399
Cdd:COG2907   322 TRPVSVTYWMNRLQGLPAPTPVFVTLNPTRPIDPEKVLARFTYEHPVFDLAAIAAQKRLPELQGRNRTWFCGAYWGYGFH 401

                         410
                  ....*....|....*...
gi 1675110109 400 EDGVRSAVEVAQRFDCHL 417
Cdd:COG2907   402 EDGLRSALRVAEALGARL 419
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 1-303 3.65e-23

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 101.06  E-value: 3.65e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109   1 MKHFAIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGGHTATVdiEKAGekHAIDTG---FIvfnnKTYPNFLALLDEIG 76
Cdd:COG1232     1 MKRVAVIGGGIAGLTAAYRLAKAgHEVTVLEASDRVGGLIRTV--EVDG--FRIDRGphsFL----TRDPEVLELLRELG 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109  77 IG----KIPTEMSFSVHNcqsGM--EYNGHNLDTLfaqRRNIFKPK-FWLLVKEILRFNKLCKsiyaqqqyiEGLTLGEF 149
Cdd:COG1232    73 LGdelvWPNTRKSYIYYG---GKlhPLPQGPLALL---RSPLLSLAgKLRALLELLAPRRPPG---------EDESLAEF 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 150 LTAhHFSDFFAEHYILPMGAAIWSSS------------LAQMEDfeftffvrffhNHGLLNIADRPQWYVIPQGSRSY-- 215
Cdd:COG1232   138 VRR-RFGREVYERLVEPLLEGVYAGDpdelsadwafprLKRLEL-----------EHGSLIKGALALRKGAKAGEVFGyl 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 216 ----------LAPLCQPfkDNIHLNANISGITRHDNKVQLHFTDSPSQTFDEVVIACHSDQALALLEDASDDEKSVLSAM 285
Cdd:COG1232   206 rgglgtlveaLAEALEA--GEIRLGTRVTAIEREGGGWRVTTSDGETIEADAVVSATPAPALARLLAPLPPEVAAALAGI 283

                         330
                  ....*....|....*....
gi 1675110109 286 PY-SANSVILHTDKKLLPK 303
Cdd:COG1232   284 PYaSVAVVALGFDRPDLPP 302
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 11-412 7.26e-23

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 100.26  E-value: 7.26e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109  11 ISGLTAAYLLAKK-HKVTVFEKNDCIGGHTATVdiEKAGEKhaIDTGFIVFNNkTYPNFLALLDEIGIgkiPTEMSFSVH 89
Cdd:pfam01593   1 LAGLAAARELLRAgHDVTVLEARDRVGGRIRTV--RDDGFL--IELGAMWFHG-AQPPLLALLKELGL---EDRLVLPDP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109  90 NCQSGM-EYNGHNLDTLFAQRRNIFkPKFWLLVKEILRFNKLCKSIYAQQQYIEG---------LTLGEFLTAHHFSDFF 159
Cdd:pfam01593  73 APFYTVlFAGGRRYPGDFRRVPAGW-EGLLEFGRLLSIPEKLRLGLAALASDALDefdlddfslAESLLFLGRRGPGDVE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 160 A-EHYILPMGAAIWSSSLAQMEDFEFTFFVRFFHNHGL-LNIADRPQWyVIPQGSRSYLAPLCQPF-KDNIHLNANISGI 236
Cdd:pfam01593 152 VwDRLIDPELFAALPFASGAFAGDPSELSAGLALPLLWaLLGEGGSLL-LPRGGLGALPDALAAQLlGGDVRLNTRVRSI 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 237 TRHDNKVQLHFTDSPSQTFDEVVIACHSD--QALALLEDASDDEKSVLSAMPY-SANSVILHTDKKLLPKRKKAWASwnY 313
Cdd:pfam01593 231 DREGDGVTVTLTDGEVIEADAVIVTVPLGvlKRILFTPPLPPEKARAIRNLGYgPVNKVHLEFDRKFWPDLGLLGLL--S 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 314 QLSQDRSKPA-SVTYNMnilQNIDSKHTFCVTL-------NQKAAIDPKEILREFT----------------YHHPVFST 369
Cdd:pfam01593 309 ELLTGLGTAFsWLTFPN---RAPPGKGLLLLVYvgpgdraRELEGLSDEELLQAVLrdlrklfgeeapeplrVLVSDWHT 385

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1675110109 370 QSI-----KAQQQRPlicGHNHT-----------HFAGAYWHSGFH---EDGVRSAVEVAQR 412
Cdd:pfam01593 386 DPWprgsySLPQYGP---GHDDYrplartpdpglFFAGEHTSTGYPgtvEGAIESGRRAARA 444
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
5-262 6.14e-18

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 85.36  E-value: 6.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109   5 AIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGGHTATVDIEKAGekHAIDTG--FIvfnNKTYPNFLALLDEIGIgkiP 81
Cdd:COG1231    11 VIVGAGLAGLAAARELRKAgLDVTVLEARDRVGGRVWTLRFGDDG--LYAELGamRI---PPSHTNLLALARELGL---P 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109  82 TEmSFSVHNCQSGMEYNG--HNLDTLFAQRRNIFKpkfwlLVKEILRfnKLCKSIYAQQQYIEGL---TLGEFLTAHHFS 156
Cdd:COG1231    83 LE-PFPNENGNALLYLGGkrVRAGEIAADLRGVAE-----LLAKLLR--ALAAALDPWAHPAAELdreSLAEWLRRNGAS 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 157 ----DFFAEHYILPMGAAIWSSSLAQMEDfeftffvrffhnhGLLNIADRPQWYVIPQGSRSYLAPLCQPFKDNIHLNAN 232
Cdd:COG1231   155 psarRLLGLLGAGEYGADPDELSLLDLLR-------------YAASAGGGAQQFRIVGGMDQLPRALAAELGDRIRLGAP 221

                         250       260       270
                  ....*....|....*....|....*....|
gi 1675110109 233 ISGITRHDNKVQLHFTDSPSQTFDEVVIAC 262
Cdd:COG1231   222 VTRIRQDGDGVTVTTDDGGTVRADAVIVTV 251
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
6-75 1.05e-15

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 71.41  E-value: 1.05e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1675110109   6 IIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGGHTATVDIekagEKHAIDTGFIVFNNKTYPNFLALLDEI 75
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRgFRVLVLEKRDRLGGNAYSYRV----PGYVFDYGAHIFHGSDEPNVRDLLDEL 67
PRK07233 PRK07233
hypothetical protein; Provisional
 3-127 8.48e-14

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 72.61  E-value: 8.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109   3 HFAIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGGHTATVDIekAG---EK--HAIdtgfivFNNKTYpnFLALLDEIG 76
Cdd:PRK07233    1 KIAIVGGGIAGLAAAYRLAKRgHEVTVFEADDQLGGLAASFEF--GGlpiERfyHHI------FKSDEA--LLELLDELG 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1675110109  77 IGK----IPTEMsfsvhncqsGMEYNG--HNLDTLFaqrrnifkpkfwllvkEILRF 127
Cdd:PRK07233   71 LEDklrwRETKT---------GYYVDGklYPLGTPL----------------ELLRF 102
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
1-322 9.72e-14

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 71.83  E-value: 9.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109   1 MKHFAIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGGHTATVDIEKAgekhAIDTGfivfnnktyPNFlalldeigigk 79
Cdd:COG3380     3 MPDIAIIGAGIAGLAAARALQDAgHEVTVFEKSRGVGGRMATRRLDGG----RFDHG---------AQY----------- 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109  80 iptemsFSVHncqsgmeynghnlDTLFAQrrnifkpkfwlLVKEILRfnklcksiyaqqqyiEGLtlgefltahhfsdff 159
Cdd:COG3380    59 ------FTAR-------------DPRFQA-----------LVEEWLA---------------AGL--------------- 78

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 160 aehyilpmgAAIWSSSLAQMEDFEFTFFVrffhnhgllniADRPQWYVIPQGSRSYLAPLCQPFkdNIHLNANISGITRH 239
Cdd:COG3380    79 ---------VAPWTFDFVVLDADGLVSPR-----------DDGEPRYVGVPGMNALAKHLAAGL--DVRLGTRVTALERD 136

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 240 DNKVQLHFTD-SPSQTFDEVVIACHSDQALALLEDASDDE-KSVLSAMPYSAN-SVILHTDKKLLPKRKKAWA-----SW 311
Cdd:COG3380   137 GDGWRLTDEDgEEYGPFDAVVLAIPAPQAAALLEPSLAPElAAALASVRYRPCwAVMLGFDQPLDPDWDAAFVddgplAW 216

                         330
                  ....*....|.
gi 1675110109 312 nyqLSQDRSKP 322
Cdd:COG3380   217 ---IARDSSKP 224
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 1-271 6.19e-12

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 66.80  E-value: 6.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109   1 MKHFAIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGGHTATVDIEKAGekHAIDTGFIVFnNKTYPNFLALLDEIGIGK 79
Cdd:COG3349     3 PPRVVVVGGGLAGLAAAVELAEAgFRVTLLEARPRLGGRARSFPDPDTG--LPIDNGQHVL-LGCYRNTLDLLRRIGAAD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109  80 I---PTEMSFSVHncqsgmeynGHNLDTLfaqRRNIFKPKFWLLVkEILRFNKL--------------CKSIYAQQQyiE 142
Cdd:COG3349    80 NlvgPEPLQFPLP---------GGRRWTL---RAPRLPAPLHLLR-ALLRAPGLsladrlallrlltaCRERRWREL--D 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 143 GLTLGEFLTAHHFSDFFAEHYILPMG-------AAIWSSSLAqmedfeftffvrffhnhglLNI------ADRPQW-YVI 208
Cdd:COG3349   145 DISVADWLRRHGQSPRLIRRLWEPLLlaalntpPEQASARLA-------------------LTVlretllAGPAASdLLV 205

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1675110109 209 PQG--SRSYLAPLCQPFKDN---IHLNANISGITRHDNKVQ-LHFTDSPSQTFDEVVIACHSDQALALL 271
Cdd:COG3349   206 PRGplSELFVDPALAYLEARggeVRLGTRVRALEFDGGRVTgLVLADGETVPADAVVLAVPPEVAARLL 274
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 1-77 1.38e-11

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 66.03  E-value: 1.38e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1675110109   1 MKHFAIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGGHTATvdIEKAGekHAIDTGFIVFnnkTYPNFLA-LLDEIGI 77
Cdd:COG1233     3 MYDVVVIGAGIGGLAAAALLARAgYRVTVLEKNDTPGGRART--FERPG--FRFDVGPSVL---TMPGVLErLFRELGL 74
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 2-293 4.95e-10

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 61.02  E-value: 4.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109   2 KHFAIIGSGISGLTAAYLLAKKH---KVTVFEKNDCIGGHTATVDieKAGekHAIDTG---FIVFNnktyPNFLALLDEI 75
Cdd:PRK11883    1 KKVAIIGGGITGLSAAYRLHKKGpdaDITLLEASDRLGGKIQTVR--KDG--FPIELGpesFLARK----PSAPALVKEL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109  76 GIGkiptemSFSVHNC--QSGMEYNG--HNL--DTLFAQRRNIFKPKFWLLVKEILRFNKLCKSIYAQQQYIEGLTLGEF 149
Cdd:PRK11883   73 GLE------DELVANTtgQSYIYVNGklHPIppGTVMGIPTSIAPFLFAGLVSPIGKLRAAADLRPPRWKPGQDQSVGAF 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 150 LtAHHFSDFFAEHYILPMGAAIWSSS------------LAQMEDfeftffvrffhNHGLLNIA---DRPQwyvipqgSRS 214
Cdd:PRK11883  147 F-RRRFGDEVVENLIEPLLSGIYAGDidtlslratfpqLAQAED-----------KYGSLLRGmrkALPK-------EKK 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109 215 YLAPLCQPFKD----------------NIHLNANISGITRHDNKVQLHFTDSPSQTFDEVVIACHSDQALALLEDasDDE 278
Cdd:PRK11883  208 KTKGVFGTLKGglqsliealeeklpagTIHKGTPVTKIDKSGDGYEIVLSNGGEIEADAVIVAVPHPVLPSLFVA--PPA 285

                         330
                  ....*....|....*
gi 1675110109 279 KSVLSAMPYSANSVI 293
Cdd:PRK11883  286 FALFKTIPSTSVATV 300
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 2-37 2.15e-09

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 58.99  E-value: 2.15e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1675110109   2 KHFAIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGG 37
Cdd:COG0493   122 KKVAVVGSGPAGLAAAYQLARAgHEVTVFEALDKPGG 158
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 2-37 6.97e-09

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 57.50  E-value: 6.97e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1675110109   2 KHFAIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGG 37
Cdd:PRK11749  141 KKVAVIGAGPAGLTAAHRLARKgYDVTIFEARDKAGG 177
PRK12814 PRK12814
putative NADPH-dependent glutamate synthase small subunit; Provisional
 2-37 4.86e-08

putative NADPH-dependent glutamate synthase small subunit; Provisional


Pssm-ID: 139246 [Multi-domain]  Cd Length: 652  Bit Score: 55.12  E-value: 4.86e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1675110109   2 KHFAIIGSGISGLTAA-YLLAKKHKVTVFEKNDCIGG 37
Cdd:PRK12814  194 KKVAIIGAGPAGLTAAyYLLRKGHDVTIFDANEQAGG 230
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 1-43 8.43e-08

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 54.07  E-value: 8.43e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1675110109   1 MKHFAIIGSGISGLTAAYLLAKKHK-----VTVFEKNDCIGGHTATVD 43
Cdd:TIGR00562   2 KKHVVIIGGGISGLCAAYYLEKEIPelpveLTLVEASDRVGGKIQTVK 49
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 2-37 1.26e-07

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 53.73  E-value: 1.26e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1675110109   2 KHFAIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGG 37
Cdd:PRK12771  138 KRVAVIGGGPAGLSAAYHLRRMgHAVTIFEAGPKLGG 174
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 2-37 1.28e-07

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 53.63  E-value: 1.28e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1675110109   2 KHFAIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGG 37
Cdd:PRK12810  144 KKVAVVGSGPAGLAAADQLARAgHKVTVFERADRIGG 180
PRK07208 PRK07208
hypothetical protein; Provisional
 1-43 1.56e-07

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 53.35  E-value: 1.56e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1675110109   1 MKHFAIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGGHTATVD 43
Cdd:PRK07208    4 KKSVVIIGAGPAGLTAAYELLKRgYPVTVLEADPVVGGISRTVT 47
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
1-37 3.55e-07

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 51.83  E-value: 3.55e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1675110109   1 MKHFAIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGG 37
Cdd:COG0665     2 TADVVVIGGGIAGLSTAYHLARRgLDVTVLERGRPGSG 39
PLN02576 PLN02576
protoporphyrinogen oxidase
 5-42 8.20e-07

protoporphyrinogen oxidase


Pssm-ID: 215314 [Multi-domain]  Cd Length: 496  Bit Score: 51.17  E-value: 8.20e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1675110109   5 AIIGSGISGLTAAYLLAKKH--KVTVFEKNDCIGGHTATV 42
Cdd:PLN02576   16 AVVGAGVSGLAAAYALASKHgvNVLVTEARDRVGGNITSV 55
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 5-39 1.10e-06

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 50.09  E-value: 1.10e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1675110109   5 AIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGGHT 39
Cdd:pfam01266   3 VVIGGGIVGLSTAYELARRgLSVTLLERGDDPGSGA 38
PRK12409 PRK12409
D-amino acid dehydrogenase small subunit; Provisional
 1-32 1.34e-06

D-amino acid dehydrogenase small subunit; Provisional


Pssm-ID: 237093 [Multi-domain]  Cd Length: 410  Bit Score: 50.02  E-value: 1.34e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1675110109   1 MKHFAIIGSGISGLTAAYLLAKK-HKVTVFEKN 32
Cdd:PRK12409    1 MSHIAVIGAGITGVTTAYALAQRgYQVTVFDRH 33
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
1-39 2.06e-06

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 49.76  E-value: 2.06e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1675110109   1 MKHFAIIGSGISGLTAAYLLAK--KHKVTVFEKNDCIGGHT 39
Cdd:COG0579     4 MYDVVIIGAGIVGLALARELSRyeDLKVLVLEKEDDVAQES 44
NadB COG0029
Aspartate oxidase [Coenzyme transport and metabolism]; Aspartate oxidase is part of the ...
 4-55 7.40e-06

Aspartate oxidase [Coenzyme transport and metabolism]; Aspartate oxidase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 439800 [Multi-domain]  Cd Length: 521  Bit Score: 48.18  E-value: 7.40e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109   4 FAIIGSGISGLTAAYLLAKKHKVTVFEKNDCIGGHT--------ATVDIEKAGEKHAIDT 55
Cdd:COG0029     7 VLVIGSGIAGLSAALKLAERGRVTLLTKGELGESNTrwaqggiaAVLDPGDSPELHIADT 66
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
6-43 8.09e-06

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 47.93  E-value: 8.09e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1675110109   6 IIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGGHTATVD 43
Cdd:COG1148   145 VIGGGIAGMTAALELAEQgYEVYLVEKEPELGGRAAQLH 183
PRK06753 PRK06753
hypothetical protein; Provisional
 5-76 2.83e-05

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 45.84  E-value: 2.83e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1675110109   5 AIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGGHTATVDIE----KAGEKHAIDTGFIVFNNKTypNFLALLDEIG 76
Cdd:PRK06753    4 AIIGAGIGGLTAAALLQEQgHEVKVFEKNESVKEVGAGIGIGdnviKKLGNHDLAKGIKNAGQIL--STMNLLDDKG 78
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 1-78 3.10e-05

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 45.70  E-value: 3.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109   1 MKHF--AIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGGHTATVDIEkagekhaidtgfivfnnktyPNFLALLDEIGI 77
Cdd:COG0654     1 MMRTdvLIVGGGPAGLALALALARAgIRVTVVERAPPPRPDGRGIALS--------------------PRSLELLRRLGL 60


                  .
gi 1675110109  78 G 78
Cdd:COG0654    61 W 61
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 5-37 5.89e-05

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 44.85  E-value: 5.89e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1675110109   5 AIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGG 37
Cdd:COG2072    10 VVIGAGQAGLAAAYHLRRAgIDFVVLEKADDVGG 43
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 6-40 1.43e-04

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 44.05  E-value: 1.43e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1675110109   6 IIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGGHTA 40
Cdd:COG1053     8 VVGSGGAGLRAALEAAEAgLKVLVLEKVPPRGGHTA 43
FAD_binding_2 pfam00890
FAD binding domain; This family includes members that bind FAD. This family includes the ...
 5-40 4.56e-04

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


Pssm-ID: 395718 [Multi-domain]  Cd Length: 398  Bit Score: 42.27  E-value: 4.56e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1675110109   5 AIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGGHTA 40
Cdd:pfam00890   3 LVIGGGLAGLAAALAAAEAgLKVAVVEKGQPFGGATA 39
PRK12831 PRK12831
putative oxidoreductase; Provisional
 2-30 5.17e-04

putative oxidoreductase; Provisional


Pssm-ID: 183780 [Multi-domain]  Cd Length: 464  Bit Score: 42.31  E-value: 5.17e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1675110109   2 KHFAIIGSGISGLTAAYLLAKK-HKVTVFE 30
Cdd:PRK12831  141 KKVAVIGSGPAGLTCAGDLAKMgYDVTIFE 170
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
1-38 1.19e-03

L-2-hydroxyglutarate oxidase;


Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 40.96  E-value: 1.19e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1675110109   1 MKHFAIIGSGISGLTAAYLLAKKH---KVTVFEKNDCIGGH 38
Cdd:PRK11728    2 MYDFVIIGGGIVGLSTAMQLQERYpgaRIAVLEKESGPARH 42
Thi4 pfam01946
Thi4 family; This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme.
 5-37 1.32e-03

Thi4 family; This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme.


Pssm-ID: 460393  Cd Length: 232  Bit Score: 40.15  E-value: 1.32e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1675110109   5 AIIGSGISGLTAAYLLAKKH--KVTVFEKNDCIGG 37
Cdd:pfam01946  21 VIVGAGSSGLTAAYYLAKNRglKVAIIERSVSPGG 55
PRK13984 PRK13984
putative oxidoreductase; Provisional
 2-37 1.43e-03

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 40.91  E-value: 1.43e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1675110109   2 KHFAIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGG 37
Cdd:PRK13984  284 KKVAIVGSGPAGLSAAYFLATMgYEVTVYESLSKPGG 320
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
10-38 1.75e-03

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 39.95  E-value: 1.75e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1675110109  10 GISGLTAAYLLAKK-HKVTVFEKNDCIGGH 38
Cdd:COG0644     2 GPAGSAAARRLARAgLSVLLLEKGSFPGDK 31
PRK12770 PRK12770
putative glutamate synthase subunit beta; Provisional
 2-31 2.19e-03

putative glutamate synthase subunit beta; Provisional


Pssm-ID: 237197 [Multi-domain]  Cd Length: 352  Bit Score: 39.97  E-value: 2.19e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1675110109   2 KHFAIIGSGISGLTAA-YLLAKKHKVTVFEK 31
Cdd:PRK12770   19 KKVAIIGAGPAGLAAAgYLACLGYEVHVYDK 49
PRK12842 PRK12842
putative succinate dehydrogenase; Reviewed
 6-41 2.56e-03

putative succinate dehydrogenase; Reviewed


Pssm-ID: 237224 [Multi-domain]  Cd Length: 574  Bit Score: 40.06  E-value: 2.56e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1675110109   6 IIGSGISGLTAAyLLAKKH--KVTVFEKNDCIGGHTAT 41
Cdd:PRK12842   14 VIGSGAGGLSAA-ITARKLglDVVVLEKEPVFGGTTAF 50
PRK12779 PRK12779
putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; ...
 5-37 2.58e-03

putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Provisional


Pssm-ID: 183740 [Multi-domain]  Cd Length: 944  Bit Score: 40.20  E-value: 2.58e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1675110109   5 AIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGG 37
Cdd:PRK12779  310 AVVGSGPSGLINAYLLAVEgFPVTVFEAFHDLGG 343
PRK08163 PRK08163
3-hydroxybenzoate 6-monooxygenase;
6-89 3.37e-03

3-hydroxybenzoate 6-monooxygenase;


Pssm-ID: 181262 [Multi-domain]  Cd Length: 396  Bit Score: 39.64  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675110109   6 IIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGGHTATVDIeKAGEKHAIDT---GFIVFNNKTYPNFLALLDEIG---IG 78
Cdd:PRK08163    9 IVGGGIGGLAAALALARQgIKVKLLEQAAEIGEIGAGIQL-GPNAFSALDAlgvGEAARQRAVFTDHLTMMDAVDaeeVV 87

                          90
                  ....*....|.
gi 1675110109  79 KIPTEMSFSVH 89
Cdd:PRK08163   88 RIPTGQAFRAR 98
PRK12778 PRK12778
bifunctional dihydroorotate dehydrogenase B NAD binding subunit/NADPH-dependent glutamate ...
 2-37 3.83e-03

bifunctional dihydroorotate dehydrogenase B NAD binding subunit/NADPH-dependent glutamate synthase;


Pssm-ID: 237200 [Multi-domain]  Cd Length: 752  Bit Score: 39.73  E-value: 3.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1675110109   2 KHFAIIGSGISGLTAAYLLAKK-HKVTVFEKNDCIGG 37
Cdd:PRK12778  432 KKVAVIGSGPAGLSFAGDLAKRgYDVTVFEALHEIGG 468
PRK09077 PRK09077
L-aspartate oxidase; Provisional
 5-55 4.29e-03

L-aspartate oxidase; Provisional


Pssm-ID: 236374 [Multi-domain]  Cd Length: 536  Bit Score: 39.13  E-value: 4.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1675110109   5 AIIGSGISGLTAAYLLAKKHKVTVFEKNDCI--------GGHTATVDIEKAGEKHAIDT 55
Cdd:PRK09077   12 LIIGSGAAGLSLALRLAEHRRVAVLSKGPLSegstfyaqGGIAAVLDETDSIESHVEDT 70
PLN02268 PLN02268
probable polyamine oxidase
 6-39 5.52e-03

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 38.90  E-value: 5.52e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1675110109   6 IIGSGISGLTAAYLLAKKH-KVTVFEKNDCIGG--HT 39
Cdd:PLN02268    5 VIGGGIAGIAAARALHDASfKVTLLESRDRIGGrvHT 41
PRK06847 PRK06847
hypothetical protein; Provisional
 1-33 5.78e-03

hypothetical protein; Provisional


Pssm-ID: 235874 [Multi-domain]  Cd Length: 375  Bit Score: 38.70  E-value: 5.78e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1675110109   1 MKHFAIIGSGISGLTAAYLLAKKH-KVTVFEKND 33
Cdd:PRK06847    4 VKKVLIVGGGIGGLSAAIALRRAGiAVDLVEIDP 37
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
2-33 6.39e-03

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 38.78  E-value: 6.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1675110109   2 KHFAIIGSGISGLTAAYLLAKKH----KVTVFEKND 33
Cdd:COG4529     6 KRIAIIGGGASGTALAIHLLRRApeplRITLFEPRP 41
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
1-33 7.37e-03

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 38.19  E-value: 7.37e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1675110109   1 MKHFAIIGSGISGLTAAYLLAKK----HKVTVFEKND 33
Cdd:COG1252     1 MKRIVIVGGGFAGLEAARRLRKKlggdAEVTLIDPNP 37
GG-red-SF TIGR02032
geranylgeranyl reductase family; This model represents a subfamily which includes ...
 6-62 8.90e-03

geranylgeranyl reductase family; This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273936 [Multi-domain]  Cd Length: 295  Bit Score: 37.68  E-value: 8.90e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1675110109   6 IIGSGISGLTAAYLLAKK-HKVTVFEKND------CIGG----HTATVDIEKAGEKHAIDTGFIVFNN 62
Cdd:TIGR02032   5 VVGAGPAGASAAYRLADKgLRVLLLEKKSfprykpCGGAlsprALEELDLPGELIVNLVRGARFFSPN 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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