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Conserved domains on  [gi|1675085986|ref|WP_138602636|]
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MULTISPECIES: penicillin-binding protein 2 [unclassified Pseudoalteromonas]

Protein Classification

penicillin-binding protein 2( domain architecture ID 11496821)

penicillin-binding protein (PBP) 2 is a membrane-associated enzyme that is involved in the synthesis of cross-linked peptidoglycan

EC:  3.4.16.4
Gene Ontology:  GO:0009252|GO:0008658|GO:0016020
PubMed:  18266856|18248419

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 20-613 0e+00

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


:

Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 954.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986  20 RRAFVGFVFVTLLIGVLLSNLYNIQVIEHQDYQTRSNDNRIKVIPIAPNRGLIYDRNGVLLAENKPVYNLEVIPEEVDNL 99
Cdd:TIGR03423   1 RRALVLGGLVLALFGVLAARLFYLQVIRGEEYATLSEDNRIRLVPIPPPRGLILDRNGVLLADNRPSFSLEIVPEKVDDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 100 EEALSEVEKVIKITEQQKADFLDDIKHNRRFKSQVLKARLDETEVAKFSVNQHKFPGFSIEARLARYYPYGDTLTHALGY 179
Cdd:TIGR03423  81 DATLDRLAKLLDLDPEDIARFLKELKRSRRFEPIPLKSDLTEEEVARFAVNQYRLPGVEIEARLKRYYPYGELAAHVLGY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 180 VAKLNKKELTKLEAEdqatNYRATHDIGKLGIEKYYEELLHGVVGSQRVEVNNRGRVIRTLSLTPPEPGHDLVLTLDIGL 259
Cdd:TIGR03423 161 VGEINEEDLERLEPA----NYAGGDYIGKSGIEKYYEDELRGKPGYREVEVNARGRVIRTLSRVPPVPGKDLVLTIDARL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 260 QQIAQHALKDMRGAIVVLDAKDGGVLALYSNPSYDPNLFVHGISSTDYKKLLN-PDRPLINRTTQGRYAPASTVKPHMSI 338
Cdd:TIGR03423 237 QQAAEKALGGRRGAVVVMDPRTGEILAMVSTPSFDPNLFVDGISSKDYKALLNdPDRPLLNRAIQGVYPPGSTFKPVVAL 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 339 LALEEGLVTEQTQIWDPGFFQIPNveHKWRDWKRWGHGHVDVYRAIEESCDTYFYDVAYRLGITKISDFMTQFGFGELSG 418
Cdd:TIGR03423 317 AALEEGVITPETRIYCPGYFQLGG--RRFRCWKRGGHGRVDLRKAIEESCDVYFYQLALRLGIDKIAEYAKRFGFGQKTG 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 419 IDIHEETSAIMPSREWKEARFRESWWRGDTISVGIGQGYWTATPMQIANATNILVNRGLDHPPHLV-QVAKKENEVTQIN 497
Cdd:TIGR03423 395 IDLPGEKSGLVPSREWKRKRFGQPWYPGDTLNVSIGQGYVLVTPLQLAVATAALANGGKLYKPHLVkSIEDPDGGVVRRT 474

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 498 NDEKPPVVLKNPHHWQIALDAMHNTVHKVTGTAHKAFKGANYDPAGKTGTAQVVSIAQGERYDAKSLKERQRDNAIYVGF 577
Cdd:TIGR03423 475 EPEVLRPLPISPENLDVVREGMRDVVNGPGGTARRARLGLPYKMAGKTGTAQVVSLKQGEKYDAEQIPERLRDHALFVAF 554

                         570       580       590
                  ....*....|....*....|....*....|....*.
gi 1675085986 578 APYNDPQIVVSVVVENTGGGSTVGAPIARQLMDYYF 613
Cdd:TIGR03423 555 APYDNPKIAVAVIVEHGGGGSSAAAPIARKIMDAYL 590
 
Name Accession Description Interval E-value
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 20-613 0e+00

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 954.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986  20 RRAFVGFVFVTLLIGVLLSNLYNIQVIEHQDYQTRSNDNRIKVIPIAPNRGLIYDRNGVLLAENKPVYNLEVIPEEVDNL 99
Cdd:TIGR03423   1 RRALVLGGLVLALFGVLAARLFYLQVIRGEEYATLSEDNRIRLVPIPPPRGLILDRNGVLLADNRPSFSLEIVPEKVDDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 100 EEALSEVEKVIKITEQQKADFLDDIKHNRRFKSQVLKARLDETEVAKFSVNQHKFPGFSIEARLARYYPYGDTLTHALGY 179
Cdd:TIGR03423  81 DATLDRLAKLLDLDPEDIARFLKELKRSRRFEPIPLKSDLTEEEVARFAVNQYRLPGVEIEARLKRYYPYGELAAHVLGY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 180 VAKLNKKELTKLEAEdqatNYRATHDIGKLGIEKYYEELLHGVVGSQRVEVNNRGRVIRTLSLTPPEPGHDLVLTLDIGL 259
Cdd:TIGR03423 161 VGEINEEDLERLEPA----NYAGGDYIGKSGIEKYYEDELRGKPGYREVEVNARGRVIRTLSRVPPVPGKDLVLTIDARL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 260 QQIAQHALKDMRGAIVVLDAKDGGVLALYSNPSYDPNLFVHGISSTDYKKLLN-PDRPLINRTTQGRYAPASTVKPHMSI 338
Cdd:TIGR03423 237 QQAAEKALGGRRGAVVVMDPRTGEILAMVSTPSFDPNLFVDGISSKDYKALLNdPDRPLLNRAIQGVYPPGSTFKPVVAL 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 339 LALEEGLVTEQTQIWDPGFFQIPNveHKWRDWKRWGHGHVDVYRAIEESCDTYFYDVAYRLGITKISDFMTQFGFGELSG 418
Cdd:TIGR03423 317 AALEEGVITPETRIYCPGYFQLGG--RRFRCWKRGGHGRVDLRKAIEESCDVYFYQLALRLGIDKIAEYAKRFGFGQKTG 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 419 IDIHEETSAIMPSREWKEARFRESWWRGDTISVGIGQGYWTATPMQIANATNILVNRGLDHPPHLV-QVAKKENEVTQIN 497
Cdd:TIGR03423 395 IDLPGEKSGLVPSREWKRKRFGQPWYPGDTLNVSIGQGYVLVTPLQLAVATAALANGGKLYKPHLVkSIEDPDGGVVRRT 474

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 498 NDEKPPVVLKNPHHWQIALDAMHNTVHKVTGTAHKAFKGANYDPAGKTGTAQVVSIAQGERYDAKSLKERQRDNAIYVGF 577
Cdd:TIGR03423 475 EPEVLRPLPISPENLDVVREGMRDVVNGPGGTARRARLGLPYKMAGKTGTAQVVSLKQGEKYDAEQIPERLRDHALFVAF 554

                         570       580       590
                  ....*....|....*....|....*....|....*.
gi 1675085986 578 APYNDPQIVVSVVVENTGGGSTVGAPIARQLMDYYF 613
Cdd:TIGR03423 555 APYDNPKIAVAVIVEHGGGGSSAAAPIARKIMDAYL 590
PRK10795 PRK10795
penicillin-binding protein 2; Provisional
 1-611 0e+00

penicillin-binding protein 2; Provisional


Pssm-ID: 236761 [Multi-domain]  Cd Length: 634  Bit Score: 775.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986   1 MRKHRPTIRDHSAEANLFARRAFVGFVFVTLLIGVLLSNLYNIQVIEHQDYQTRSNDNRIKVIPIAPNRGLIYDRNGVLL 80
Cdd:PRK10795    1 MKKLQNSFRDYTAESALFVRRALVAFLGILLLTGVLIANLYNLQIVRFTDYQTRSNENRIKLVPIAPSRGIIYDRNGTPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986  81 AENKPVYNLEVIPEEVDNLEEALSEVEKVIKITEQQKADFLDDIKHNRRFKSQVLKARLDETEVAKFSVNQHKFPGFSIE 160
Cdd:PRK10795   81 ALNRTIYQLEMMPEKVDNLQQTLDALRSVVDLTDDDIAAFRKERARSRRFTSIPVKTNLTEVQVARFAVNQYRFPGVEVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 161 ARLARYYPYGDTLTHALGYVAKLNKKELTKLEAEDQATNYRATHDIGKLGIEKYYEELLHGVVGSQRVEVNNRGRVIRTL 240
Cdd:PRK10795  161 GYQRRYYPYGSALTHVIGYVSKINDKDVERLDKEGKLANYAATHDIGKLGIERYYEDVLHGKTGYEEVEVNNRGRVIRQL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 241 SLTPPEPGHDLVLTLDIGLQQIAQHALKDMRGAIVVLDAKDGGVLALYSNPSYDPNLFVHGISSTDYKKLLN-PDRPLIN 319
Cdd:PRK10795  241 HEQPPQAGHDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGGILALVSTPSYDPNLFVDGISSKDYSGLLNdPNRPLIN 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 320 RTTQGRYAPASTVKPHMSILALEEGLVTEQTQIWDPGFFQIPNVEHKWRDWKRWGHGHVDVYRAIEESCDTYFYDVAYRL 399
Cdd:PRK10795  321 RATQGVYPPASTVKPYVAVSALSAGVITRNTSLFDPGWWQLPGSEKRYRDWKKWGHGRLNVTKSLEESADTFFYQVAYDM 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 400 GITKISDFMTQFGFGELSGIDIHEETSAIMPSREWKEARFRESWWRGDTISVGIGQGYWTATPMQIANATNILVNRGLDH 479
Cdd:PRK10795  401 GIDRLSEWMGKFGYGHYTGIDLAEERSGNMPTREWKQKRFKKPWYQGDTIPVGIGQGYWTATPIQMSKALMTLINDGIVK 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 480 PPHLVQVAKKENEVTQINNDEKPPVVLKNPHHWQIALDAMHNTVHKVTGTAHKAFKGANYDPAGKTGTAQVVSIAQGERY 559
Cdd:PRK10795  481 VPHLLMSTAEDGKQVPWVQPHEPPVGDIHSGYWEIAKDGMYGVANRPNGTAHKYFASAPYKIAAKSGTAQVFGLKANETY 560

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1675085986 560 DAKSLKERQRDNAIYVGFAPYNDPQIVVSVVVENTGGGSTVGApIARQLMDY 611
Cdd:PRK10795  561 NAHKIAERLRDHKLMTAFAPYNNPQVAVAIILENGGAGPAVGT-IMRQILDH 611
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 11-613 0e+00

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 651.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986  11 HSAEANLFARRAFVGFVFVTLLIGVLLSNLYNIQVIEHQDYQTRSNDNRIKVIPIAPNRGLIYDRNGVLLAENKPVYNLE 90
Cdd:COG0768     3 RKKEKRLFRRRLLLLFLLVLLLFLLLVGRLFYLQVVEGDEYAELAEENRIRTVPIPAPRGLIYDRNGNVLATNVPVYSLY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986  91 VIPEEVDNLEEALSEVEKVIKITEqqkADFLDDIKHNRRFkSQVLKARLDETEVAKfsVNQHKFPGFSIEARLARYYPYG 170
Cdd:COG0768    83 ADPEEVKDPEETAEKLAKLLGLDP---EELRKKLKKKSRF-PVYLKRNLSPEEAAR--IRALKLPGVYVEAEYKRYYPYG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 171 DTLTHALGYVAKLNkkeltkleaedqatnyrATHDIGKLGIEKYYEELLHGVVGSQRVEVNNRGRVIRTL-SLTPPEPGH 249
Cdd:COG0768   157 ELAAHVLGYVGEIN-----------------GGDGIGKSGLEKAYEDLLRGTPGKRRVEVDARGRVIRDLgEEKPPVPGK 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 250 DLVLTLDIGLQQIAQHALKDM-------RGAIVVLDAKDGGVLALYSNPSYDPNLFVHGisstdykkllnPDRPLINRTT 322
Cdd:COG0768   220 DLVLTIDSDLQKIAEEALKKAveeykakSGAVVVMDPKTGEILAMASYPSFDPNLFVGG-----------PDEPLRNRAV 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 323 QGRYAPASTVKPHMSILALEEGLVTEQTQIWDPGFFQIPNveHKWRDWKRWGHGHVDVYRAIEESCDTYFYDVAYRLGIT 402
Cdd:COG0768   289 QGTYEPGSTFKPFTAAAALEEGVITPDTTFDCPGYYRVGG--RTIRDWDRGGHGTLTLTEALAKSSNVGFYKLALRLGID 366

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 403 KISDFMTQFGFGELSGIDIHEETSAIMPSrewkearfRESWWRGDTISVGIGQGyWTATPMQIANATNILVNRGLDHPPH 482
Cdd:COG0768   367 KLYDYLKKFGLGQKTGIDLPGEASGLLPS--------PKRWYPGETATMSIGQG-LSVTPLQLAQAYAAIANGGVLVKPH 437

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 483 LVQ-VAKKENEVTQINNDEKPPVVlkNPHHWQIALDAMHNTVHKVTGTAHKAfKGANYDPAGKTGTAQVVSIAQGERYda 561
Cdd:COG0768   438 LVKeIVDPDGEVVKEEPEVLRRVI--SPETAETVREGMEGVVNEPGGTARRA-AIPGYRVAGKTGTAQVVDIGNGGYY-- 512

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1675085986 562 kslkeRQRDNAIYVGFAPYNDPQIVVSVVVENTGG---GSTVGAPIARQLMDYYF 613
Cdd:COG0768   513 -----KGRHIASFVGFAPADNPRYAVAVVVENPGGgayGGTVAAPVFREIMEAYL 562
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 272-610 2.08e-70

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 229.61  E-value: 2.08e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 272 GAIVVLDAKDGGVLALYSNPSYDPNLFVhgisstdykkllnpdRPLINRTTQGRYAPASTVKPHMSILALEEGLVTEQTQ 351
Cdd:pfam00905   1 GSAVVLDPKTGEVLAMVGKPSYDPNGFI---------------GPLRNRAVTSRYEPGSTFKPFTALAALDNGVLKPDET 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 352 IWDPGFFQIPNVEhkWRDWKRWGHGHVDVYRAIEESCDTYFYDVAYRLGITKISDFMTQFGFGELSGIDIHEETSAIMPS 431
Cdd:pfam00905  66 IFDWPGKQQGGKS--IGDWNQDQVGIGTLRQALEYSSNWYMQKLAQKLGADKLRSYLKKFGYGNKTGIGLPGENAGYLTP 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 432 RewkearfresWWRGDTISVGIGqgyWTATPMQIANATNILVNRGLDHPPHLVQVAKKENEVTQINndeKPPVvlkNPHH 511
Cdd:pfam00905 144 Y----------WLEGATASFGIG---LTITPLQQAQAYAAIANGGKLVPPHLVKSIEDKVDPKVLN---KLPI---SKST 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 512 WQIALDAMHNTVHKVTGTAHKAFKGanYDPAGKTGTAQVVSiAQGERYDAKslkerqRDNAIYVGFAPYNDPQIVVSVVV 591
Cdd:pfam00905 205 AEKVKDMLRLVVNDGTGTGTAAVPG--YKVAGKTGTAQVAG-PKGGGYYDG------AQIGWFVGYAPADNPKYAFAVLI 275

                         330       340
                  ....*....|....*....|.
gi 1675085986 592 ENTGG--GSTVGAPIARQLMD 610
Cdd:pfam00905 276 DDPKRyyGGKVAAPIFKDILE 296
 
Name Accession Description Interval E-value
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 20-613 0e+00

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 954.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986  20 RRAFVGFVFVTLLIGVLLSNLYNIQVIEHQDYQTRSNDNRIKVIPIAPNRGLIYDRNGVLLAENKPVYNLEVIPEEVDNL 99
Cdd:TIGR03423   1 RRALVLGGLVLALFGVLAARLFYLQVIRGEEYATLSEDNRIRLVPIPPPRGLILDRNGVLLADNRPSFSLEIVPEKVDDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 100 EEALSEVEKVIKITEQQKADFLDDIKHNRRFKSQVLKARLDETEVAKFSVNQHKFPGFSIEARLARYYPYGDTLTHALGY 179
Cdd:TIGR03423  81 DATLDRLAKLLDLDPEDIARFLKELKRSRRFEPIPLKSDLTEEEVARFAVNQYRLPGVEIEARLKRYYPYGELAAHVLGY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 180 VAKLNKKELTKLEAEdqatNYRATHDIGKLGIEKYYEELLHGVVGSQRVEVNNRGRVIRTLSLTPPEPGHDLVLTLDIGL 259
Cdd:TIGR03423 161 VGEINEEDLERLEPA----NYAGGDYIGKSGIEKYYEDELRGKPGYREVEVNARGRVIRTLSRVPPVPGKDLVLTIDARL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 260 QQIAQHALKDMRGAIVVLDAKDGGVLALYSNPSYDPNLFVHGISSTDYKKLLN-PDRPLINRTTQGRYAPASTVKPHMSI 338
Cdd:TIGR03423 237 QQAAEKALGGRRGAVVVMDPRTGEILAMVSTPSFDPNLFVDGISSKDYKALLNdPDRPLLNRAIQGVYPPGSTFKPVVAL 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 339 LALEEGLVTEQTQIWDPGFFQIPNveHKWRDWKRWGHGHVDVYRAIEESCDTYFYDVAYRLGITKISDFMTQFGFGELSG 418
Cdd:TIGR03423 317 AALEEGVITPETRIYCPGYFQLGG--RRFRCWKRGGHGRVDLRKAIEESCDVYFYQLALRLGIDKIAEYAKRFGFGQKTG 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 419 IDIHEETSAIMPSREWKEARFRESWWRGDTISVGIGQGYWTATPMQIANATNILVNRGLDHPPHLV-QVAKKENEVTQIN 497
Cdd:TIGR03423 395 IDLPGEKSGLVPSREWKRKRFGQPWYPGDTLNVSIGQGYVLVTPLQLAVATAALANGGKLYKPHLVkSIEDPDGGVVRRT 474

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 498 NDEKPPVVLKNPHHWQIALDAMHNTVHKVTGTAHKAFKGANYDPAGKTGTAQVVSIAQGERYDAKSLKERQRDNAIYVGF 577
Cdd:TIGR03423 475 EPEVLRPLPISPENLDVVREGMRDVVNGPGGTARRARLGLPYKMAGKTGTAQVVSLKQGEKYDAEQIPERLRDHALFVAF 554

                         570       580       590
                  ....*....|....*....|....*....|....*.
gi 1675085986 578 APYNDPQIVVSVVVENTGGGSTVGAPIARQLMDYYF 613
Cdd:TIGR03423 555 APYDNPKIAVAVIVEHGGGGSSAAAPIARKIMDAYL 590
PRK10795 PRK10795
penicillin-binding protein 2; Provisional
 1-611 0e+00

penicillin-binding protein 2; Provisional


Pssm-ID: 236761 [Multi-domain]  Cd Length: 634  Bit Score: 775.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986   1 MRKHRPTIRDHSAEANLFARRAFVGFVFVTLLIGVLLSNLYNIQVIEHQDYQTRSNDNRIKVIPIAPNRGLIYDRNGVLL 80
Cdd:PRK10795    1 MKKLQNSFRDYTAESALFVRRALVAFLGILLLTGVLIANLYNLQIVRFTDYQTRSNENRIKLVPIAPSRGIIYDRNGTPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986  81 AENKPVYNLEVIPEEVDNLEEALSEVEKVIKITEQQKADFLDDIKHNRRFKSQVLKARLDETEVAKFSVNQHKFPGFSIE 160
Cdd:PRK10795   81 ALNRTIYQLEMMPEKVDNLQQTLDALRSVVDLTDDDIAAFRKERARSRRFTSIPVKTNLTEVQVARFAVNQYRFPGVEVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 161 ARLARYYPYGDTLTHALGYVAKLNKKELTKLEAEDQATNYRATHDIGKLGIEKYYEELLHGVVGSQRVEVNNRGRVIRTL 240
Cdd:PRK10795  161 GYQRRYYPYGSALTHVIGYVSKINDKDVERLDKEGKLANYAATHDIGKLGIERYYEDVLHGKTGYEEVEVNNRGRVIRQL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 241 SLTPPEPGHDLVLTLDIGLQQIAQHALKDMRGAIVVLDAKDGGVLALYSNPSYDPNLFVHGISSTDYKKLLN-PDRPLIN 319
Cdd:PRK10795  241 HEQPPQAGHDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGGILALVSTPSYDPNLFVDGISSKDYSGLLNdPNRPLIN 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 320 RTTQGRYAPASTVKPHMSILALEEGLVTEQTQIWDPGFFQIPNVEHKWRDWKRWGHGHVDVYRAIEESCDTYFYDVAYRL 399
Cdd:PRK10795  321 RATQGVYPPASTVKPYVAVSALSAGVITRNTSLFDPGWWQLPGSEKRYRDWKKWGHGRLNVTKSLEESADTFFYQVAYDM 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 400 GITKISDFMTQFGFGELSGIDIHEETSAIMPSREWKEARFRESWWRGDTISVGIGQGYWTATPMQIANATNILVNRGLDH 479
Cdd:PRK10795  401 GIDRLSEWMGKFGYGHYTGIDLAEERSGNMPTREWKQKRFKKPWYQGDTIPVGIGQGYWTATPIQMSKALMTLINDGIVK 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 480 PPHLVQVAKKENEVTQINNDEKPPVVLKNPHHWQIALDAMHNTVHKVTGTAHKAFKGANYDPAGKTGTAQVVSIAQGERY 559
Cdd:PRK10795  481 VPHLLMSTAEDGKQVPWVQPHEPPVGDIHSGYWEIAKDGMYGVANRPNGTAHKYFASAPYKIAAKSGTAQVFGLKANETY 560

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1675085986 560 DAKSLKERQRDNAIYVGFAPYNDPQIVVSVVVENTGGGSTVGApIARQLMDY 611
Cdd:PRK10795  561 NAHKIAERLRDHKLMTAFAPYNNPQVAVAIILENGGAGPAVGT-IMRQILDH 611
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 11-613 0e+00

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 651.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986  11 HSAEANLFARRAFVGFVFVTLLIGVLLSNLYNIQVIEHQDYQTRSNDNRIKVIPIAPNRGLIYDRNGVLLAENKPVYNLE 90
Cdd:COG0768     3 RKKEKRLFRRRLLLLFLLVLLLFLLLVGRLFYLQVVEGDEYAELAEENRIRTVPIPAPRGLIYDRNGNVLATNVPVYSLY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986  91 VIPEEVDNLEEALSEVEKVIKITEqqkADFLDDIKHNRRFkSQVLKARLDETEVAKfsVNQHKFPGFSIEARLARYYPYG 170
Cdd:COG0768    83 ADPEEVKDPEETAEKLAKLLGLDP---EELRKKLKKKSRF-PVYLKRNLSPEEAAR--IRALKLPGVYVEAEYKRYYPYG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 171 DTLTHALGYVAKLNkkeltkleaedqatnyrATHDIGKLGIEKYYEELLHGVVGSQRVEVNNRGRVIRTL-SLTPPEPGH 249
Cdd:COG0768   157 ELAAHVLGYVGEIN-----------------GGDGIGKSGLEKAYEDLLRGTPGKRRVEVDARGRVIRDLgEEKPPVPGK 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 250 DLVLTLDIGLQQIAQHALKDM-------RGAIVVLDAKDGGVLALYSNPSYDPNLFVHGisstdykkllnPDRPLINRTT 322
Cdd:COG0768   220 DLVLTIDSDLQKIAEEALKKAveeykakSGAVVVMDPKTGEILAMASYPSFDPNLFVGG-----------PDEPLRNRAV 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 323 QGRYAPASTVKPHMSILALEEGLVTEQTQIWDPGFFQIPNveHKWRDWKRWGHGHVDVYRAIEESCDTYFYDVAYRLGIT 402
Cdd:COG0768   289 QGTYEPGSTFKPFTAAAALEEGVITPDTTFDCPGYYRVGG--RTIRDWDRGGHGTLTLTEALAKSSNVGFYKLALRLGID 366

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 403 KISDFMTQFGFGELSGIDIHEETSAIMPSrewkearfRESWWRGDTISVGIGQGyWTATPMQIANATNILVNRGLDHPPH 482
Cdd:COG0768   367 KLYDYLKKFGLGQKTGIDLPGEASGLLPS--------PKRWYPGETATMSIGQG-LSVTPLQLAQAYAAIANGGVLVKPH 437

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 483 LVQ-VAKKENEVTQINNDEKPPVVlkNPHHWQIALDAMHNTVHKVTGTAHKAfKGANYDPAGKTGTAQVVSIAQGERYda 561
Cdd:COG0768   438 LVKeIVDPDGEVVKEEPEVLRRVI--SPETAETVREGMEGVVNEPGGTARRA-AIPGYRVAGKTGTAQVVDIGNGGYY-- 512

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1675085986 562 kslkeRQRDNAIYVGFAPYNDPQIVVSVVVENTGG---GSTVGAPIARQLMDYYF 613
Cdd:COG0768   513 -----KGRHIASFVGFAPADNPRYAVAVVVENPGGgayGGTVAAPVFREIMEAYL 562
spoVD_pbp TIGR02214
stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the ...
 21-626 5.10e-74

stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the cell division protein FtsI, a penicillin binding protein. This subfamily is restricted to Bacillus subtilis and related Gram-positive species with known or suspected endospore formation capability. In these species, the functional equivalent of FtsI is desginated PBP-2B, a paralog of spoVD. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Sporulation and germination]


Pssm-ID: 131269 [Multi-domain]  Cd Length: 636  Bit Score: 249.34  E-value: 5.10e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986  21 RAFVGFVFVTLLIGVLLSNLYNIQVIEHQDYQTRSNDNRIKVIPIAPNRGLIYDRNGVLLAENKPVYNLEVIPEEV-DNL 99
Cdd:TIGR02214   1 RSIHILISFTALFLILILRLFYVQVFRGSFYKEMAEDQWTREIPIEAKRGRILDRNGNELAVSVSVDRVDLDPATIrKNK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 100 EEALSEV-EKVIKITEQQKADFLDDI-KHNRRFKSQVLKARLDETEVAKfsVNQHKFPGFSIEARLARYYPYGDTLTHAL 177
Cdd:TIGR02214  81 EPKQREIaNELARVLEMDKEKVFKRItKKNSPFVSAKLGRKIEKDKAEK--VRNLKLNGVSVSPDSKRYYPNGDFLSHVL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 178 GYvaklnkkelTKLEAEdqatnyrathdiGKLGIEKYYEELLHGVVGSQRVEVNNRGRVIRTL--SLTPPEPGHDLVLTL 255
Cdd:TIGR02214 159 GF---------TNSDGR------------GLEGLELYYDKELRGLPGVRVAEYDANSLELPYAqhAYVKPVDGHDLVLTI 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 256 DIGLQQIAQHALKDM------RGA-IVVLDAKDGGVLALYSNPSYDPNLFVHGISSTDYKkllnpdrpliNRTTQGRYAP 328
Cdd:TIGR02214 218 DENIQYIIEREADKAlrerkpKGVsIIVMNPKNGEILGMSNRPTYDPNDPRDKSPDTARR----------NRAVSDAYEP 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 329 ASTVKPHMSILALEEGLVTEQTQIWDPGFFQIPNveHKWRDWKRWGHGHVDVYRAIEESCDTYFYDVAYRLGITKISDFM 408
Cdd:TIGR02214 288 GSTFKIITSSAAMEEGIVKESDKFYDDGSATVGG--KKIKCWKPGGHGSQTFPEVVQNSCNPGFIELGMRLGAEKLNNYI 365

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 409 TQFGFGELSGIDIHEETSAIM-PSREWKEArfreswwrgDTISVGIGQGYwTATPMQIANATNILVNRGLDHPPHLVQ-- 485
Cdd:TIGR02214 366 LAFGFGSKTGIDLPGEAAGILvPKKKVGPV---------DLATISFGQAN-TVTPIQLMTAVNAVANGGKLIQPHIMKei 435

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 486 VAKKENEVTQinndEKPPVVLKNPHHWQIAL---DAMHNTVHKvtGTAHKAF-KGanYDPAGKTGTAQVVSIAQGerYDA 561
Cdd:TIGR02214 436 SDSQNNAVDQ----TFEPEVKRQVVSKETTQklrLALETVVSK--GSGKNAFiEG--YRVGGKTGTAQKVKPNGG--YME 505

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1675085986 562 KSLKerqrdnAIYVGFAPYNDPQIVVSVVVENTGG----GSTVGAPIARQLMD---YYFSANPiQIAQSDAP 626
Cdd:TIGR02214 506 GEYI------VSFVGFAPADDPAVAVLVVVDNPKGvqqfGGLVAAPVFGSVFNdilNYLGIKP-QMNQGEAP 570
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 272-610 2.08e-70

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 229.61  E-value: 2.08e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 272 GAIVVLDAKDGGVLALYSNPSYDPNLFVhgisstdykkllnpdRPLINRTTQGRYAPASTVKPHMSILALEEGLVTEQTQ 351
Cdd:pfam00905   1 GSAVVLDPKTGEVLAMVGKPSYDPNGFI---------------GPLRNRAVTSRYEPGSTFKPFTALAALDNGVLKPDET 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 352 IWDPGFFQIPNVEhkWRDWKRWGHGHVDVYRAIEESCDTYFYDVAYRLGITKISDFMTQFGFGELSGIDIHEETSAIMPS 431
Cdd:pfam00905  66 IFDWPGKQQGGKS--IGDWNQDQVGIGTLRQALEYSSNWYMQKLAQKLGADKLRSYLKKFGYGNKTGIGLPGENAGYLTP 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 432 RewkearfresWWRGDTISVGIGqgyWTATPMQIANATNILVNRGLDHPPHLVQVAKKENEVTQINndeKPPVvlkNPHH 511
Cdd:pfam00905 144 Y----------WLEGATASFGIG---LTITPLQQAQAYAAIANGGKLVPPHLVKSIEDKVDPKVLN---KLPI---SKST 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 512 WQIALDAMHNTVHKVTGTAHKAFKGanYDPAGKTGTAQVVSiAQGERYDAKslkerqRDNAIYVGFAPYNDPQIVVSVVV 591
Cdd:pfam00905 205 AEKVKDMLRLVVNDGTGTGTAAVPG--YKVAGKTGTAQVAG-PKGGGYYDG------AQIGWFVGYAPADNPKYAFAVLI 275

                         330       340
                  ....*....|....*....|.
gi 1675085986 592 ENTGG--GSTVGAPIARQLMD 610
Cdd:pfam00905 276 DDPKRyyGGKVAAPIFKDILE 296
PBP_dimer pfam03717
Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of ...
 64-239 2.35e-51

Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerization. The domain forms a largely disordered 'sugar tongs' structure.


Pssm-ID: 427460 [Multi-domain]  Cd Length: 178  Bit Score: 175.20  E-value: 2.35e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986  64 PIAPNRGLIYDRNGVLLAENKPVYNLEVIPEEVDNlEEALSEVEKVIKITEQQKADFLDDIK-------HNRRFKSQVLK 136
Cdd:pfam03717   1 PIPAPRGEIYDRNGVVLATNKPVYSLTITPSKLKK-ADALKTALKLAKLLSNYEDLDDEDLTerflkmnSYKSYYPVVIK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 137 ARLDETEVAKFSVNQHKFPGFSIEARLARYYPYGDTLTHALGYVAKLNKKELTKLEAEDqatnYRATHDIGKLGIEKYYE 216
Cdd:pfam03717  80 KNLSEEEVARIEENLLELPGVSIETDPVRYYPYGELAAHLLGYVGEITEEELEKYLDKG----YSRGDLVGKSGLEKQYE 155

                         170       180
                  ....*....|....*....|...
gi 1675085986 217 ELLHGVVGSQRVEVNNRGRVIRT 239
Cdd:pfam03717 156 SVLRGKDGVRQVEVDALGRVIRE 178
PRK15105 PRK15105
peptidoglycan synthase FtsI; Provisional
 22-609 2.73e-32

peptidoglycan synthase FtsI; Provisional


Pssm-ID: 185060 [Multi-domain]  Cd Length: 578  Bit Score: 131.87  E-value: 2.73e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986  22 AFVGFVFVTL-------LIGVLLSNLYnIQVIeHQDYQTRSNDNR-IKVIPIAPNRGLIYDRNGVLLAENKPVYNLEVIP 93
Cdd:PRK15105   17 NFISWRFALLcgcillaLVFLLGRVAW-LQVI-NPDMLVREGDMRsLRVQEVSTSRGMITDRSGRPLAVSVPVKAIWADP 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986  94 EEV--------DNLEEALSEVekvIKITEQQKADFLDDiKHNRRFksqVLKARLDETEVAKFsVNQHKFPGFSIEARLAR 165
Cdd:PRK15105   95 KEVhdaggisvDDRWKALADA---LNIPLDQLSARINA-NPKGRF---IYLARQVNPDMADY-IKKLKLPGIHLREESRR 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 166 YYPYGDTLTHALGYvaklnkkelTKLEAEdqatnyrathdiGKLGIEKYYEELLHGVVGSQRVEVNNRGRVIRTLSLTPP 245
Cdd:PRK15105  167 YYPSGEVTAHLIGF---------TNVDSQ------------GIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDISSTDS 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 246 EPGHDLVLTLDIGLQQIAQHAL-------KDMRGAIVVLDAKDGGVLALYSNPSYDPNlfvhGISSTdykkllnPDRPLI 318
Cdd:PRK15105  226 QAAHNLALSIDERLQALVYRELnnavafnKAESGSAVLVDVNTGEVLAMANSPSYNPN----NLSGT-------PKDAMR 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 319 NRTTQGRYAPASTVKPHMSILALEEGLVTEQTQIwDPGFFQIPNveHKWRDWKRWghGHVDVYRAIEESCDTYFYDVAYR 398
Cdd:PRK15105  295 NRAITDVFEPGSTVKPMVVMTALQRGVVKENSVL-NTVPYRING--HEIKDVARY--SELTLTGVLQKSSNVGVSKLALA 369

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 399 LGITKISDFMTQFGFGELSGIDIHEETSAIMPSREwkearfRESWWRGDTISVGIGqgyWTATPMQIANATNILVNRGLD 478
Cdd:PRK15105  370 MPSSALVDTYSRFGLGKATNLGLVGERSGLYPQKQ------RWSDIERATFSFGYG---LMVTPLQLARVYATIGSYGIY 440

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 479 HPPHLVQVakkenevtqinndeKPPVvlknPHHWQIALDAMHNTVHKVTGTA-------HKAFKGanYDPAGKTGTAQVV 551
Cdd:PRK15105  441 RPLSITKV--------------DPPV----PGERVFPESIVRTVVHMMESVAlpggggvKAAIKG--YRIAIKTGTAKKV 500

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1675085986 552 siAQGERYDAKSLkerqrdnAIYVGFAPYNDPQIVVSVVVENTGGGS----TVGAPIARQLM 609
Cdd:PRK15105  501 --GPDGRYINKYI-------AYTAGVAPASQPRFALVVVINDPQAGKyyggAVSAPVFGAIM 553
MrcB COG0744
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
 229-619 1.53e-30

Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440507 [Multi-domain]  Cd Length: 630  Bit Score: 126.96  E-value: 1.53e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 229 EVNNRGRVIRTlsltppepghdlvlTLDIGLQQIAQHALKD---------MRGAIVVLDAKDGGVLALYSNPSYDPNLFv 299
Cdd:COG0744   289 DLYRGGLKIYT--------------TLDPKLQKAAEKAVKNvlpegkpggLQAALVVVDPKTGEVLAMVGGRDYGKSQF- 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 300 hgisstdykkllnpdrpliNRTTQGRYAPASTVKPHMSILALEEGLVTEQT-----QIWDPGFFQIPNVEHKWrdwkrwg 374
Cdd:COG0744   354 -------------------NRATQAKRQPGSTFKPFVYAAALEQGYTPATTvddepVTFPGGGWSPKNYDGRY------- 407

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 375 HGHVDVYRAIEESCDTYFYDVAYRLGITKISDFMTQFGfgelsgidIHEETSAimpsrewkearfreswwrgdTISVGIG 454
Cdd:COG0744   408 RGPVTLREALANSLNTPAVRLAQEVGLDKVVDTARRLG--------ITSPLDP--------------------NPSLALG 459

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 455 QGywTATPMQIANATNILVNRGLDHPPHLV-QVAKKENEVTQINNDEKPPVVlkNPHHWQIALDAMHNTVHKvtGTAHKA 533
Cdd:COG0744   460 TS--EVSPLEMASAYATFANGGVYVEPHAItKVTDADGKVLYEAKPKCEQVI--SPEVAYLMTDMLQDVVTS--GTGRAA 533

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 534 fKGANYDPAGKTGTAQvvsiaqgeryDAKSlkerqrdnAIYVGFapynDPQIVVSVVVENTGG-------GSTVGAPIAR 606
Cdd:COG0744   534 -RLPGRPVAGKTGTTN----------DNRD--------AWFVGY----TPQLVTAVWVGNDDNspmgyvtGGSLPAPIWR 590

                         410
                  ....*....|...
gi 1675085986 607 QLMDYYFSANPIQ 619
Cdd:COG0744   591 DFMEAALEGLPVE 603
PBP_1a_fam TIGR02074
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ...
 247-612 9.41e-20

penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273955 [Multi-domain]  Cd Length: 531  Bit Score: 93.09  E-value: 9.41e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 247 PGHDLVLTLDIGLQQIAQHALK------------DMRGAIVVLDAKDGGVLALYSNPSYDPNLFvhgisstdykkllnpd 314
Cdd:TIGR02074 220 GGLKIYTTLDLDAQKAAEKVLNtglrvagrrdgdDLQAALVAIDPDTGAVRALVGGRDYGKSQF---------------- 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 315 rpliNRTTQGRYAPASTVKPHMSILALEEGLVTEQT-----QIWDPGFFQIP-NVEHKWRdwkrwghGHVDVYRAIEESC 388
Cdd:TIGR02074 284 ----NRATQAKRQPGSTFKPFVYAAALEKGLTPATIvndepITYNGNGPWSPkNYGGGYR-------GNVTLRQALAQSR 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 389 DTYFYDVAYRLGITKISDFMTQFGFgelsgidiheeTSAIMPSrewkearfreswwrgdtISVGIGQGywTATPMQIANA 468
Cdd:TIGR02074 353 NIPAVRLLQEVGLDKVVALAKRFGI-----------TSPLDPV-----------------LSLALGTV--EVSPLEMASA 402

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 469 TNILVNRGLDHPPHLV-QVAKKENEVTqINNDEKPPVVLKNPHHWQIAlDAMHNTVHKVTGTAHKAFkgaNYDPAGKTGT 547
Cdd:TIGR02074 403 YAVFANGGKYVEPHGIrKIVDRDGKVI-YENKPKTTQVISPATAYIMT-DMLKGVVESGTGRSARLP---GRPVAGKTGT 477

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1675085986 548 AQvvsiaqgeryDAKslkerqrdNAIYVGFAPYndpqIVVSVVVEN--------TGGGSTVGAPIARQLMDYY 612
Cdd:TIGR02074 478 TQ----------NWR--------DAWFVGYTPY----YVTAVWVGYddkktlgkSGTGGGLAAPIWRDFMAEA 528
MrcA COG5009
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
272-609 6.12e-09

Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444033 [Multi-domain]  Cd Length: 785  Bit Score: 59.02  E-value: 6.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 272 GAIVVLDAKDGGVLALysnpsydpnlfVHGISSTDYKkllnpdrplINRTTQGRYAPASTVKPhmsIL---ALEEGLvTE 348
Cdd:COG5009   423 GALVALDPHTGAVLAL-----------VGGFDFEQSK---------FNRATQAKRQPGSSFKP---FVyaaALDNGY-TP 478

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 349 QTQIWD-PGFFQIPNVEHKWR--DWKRWGHGHVDVYRAIEESCDTyfydVAYRL----GITKISDFMTQFGFGELsgidi 421
Cdd:COG5009   479 ATIINDaPIVFDDGGGGGVWRpkNYSGKFYGPTTLREALEKSRNL----VTVRLlqdvGIDYVIDYAERFGIYSK----- 549

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 422 heetsaiMPsrewkearfreswwRGDTISVGIGqgywTATPMQIANATNILVNRGLDHPPHLVQ--------------VA 487
Cdd:COG5009   550 -------LP--------------PNLSLALGSG----EVTPLEMARAYAVFANGGYRVEPYLIDriedrngkviyradPA 604

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 488 KKENEVTQINNDEKPPVVLKNPHH-------WQIAlDAMHNTVHKvtGTAHKAfKGANYDPAGKTGTAQvvsiaqgeryD 560
Cdd:COG5009   605 RACEDCDAAEWDGAEPRLPDPAEQvidprtaYQMT-SMLRGVVQR--GTGRRA-RALGRDIAGKTGTTN----------D 670

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1675085986 561 AKslkerqrdNAIYVGFAPYndpqIVVSVVV-----ENTGG---GSTVGAPIARQLM 609
Cdd:COG5009   671 SK--------DAWFVGFTPD----LVAGVWVgfddpRSLGRgetGGRAALPIWIDFM 715
YbxI COG2602
Beta-lactamase class D [Defense mechanisms];
325-420 1.86e-06

Beta-lactamase class D [Defense mechanisms];


Pssm-ID: 442014 [Multi-domain]  Cd Length: 267  Bit Score: 49.88  E-value: 1.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675085986 325 RYAPASTVKPHMSILALEEGLVTEQTQI--WDpGffqipnvehKWRDWKRWGHGHvDVYRAIEESCDTYFYDVAYRLGIT 402
Cdd:COG2602    67 RFSPASTFKIPNSLIALETGVIKDENEVfkWD-G---------VKRPFPAWNRDM-TLRSAFKVSAVWYYQELARRIGKE 135

                          90       100
                  ....*....|....*....|.
gi 1675085986 403 KISDFMTQFGFGEL---SGID 420
Cdd:COG2602   136 RMQKYLDKLNYGNAdisGGID 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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