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Conserved domains on  [gi|1673538796|ref|NP_001357695|]
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DNA repair and recombination protein RAD54-like isoform 2 [Homo sapiens]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 13208550)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA; similar to Hamiltonella virus protein p41

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEAD-like_helicase_N super family cl28899
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ...
 1-215 7.79e-154

N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.


The actual alignment was detected with superfamily member cd18067:

Pssm-ID: 475120 [Multi-domain]  Cd Length: 243  Bit Score: 440.37  E-value: 7.79e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKPEIDKAVVVSPSSLVKNWYNEVGKWLGGRIQPLAIDGGSKDEIDQKLEGFMN 80
Cdd:cd18067    29 MADEMGLGKTLQCITLMWTLLRQSPQCKPEIDKAIVVSPSSLVKNWANELGKWLGGRLQPLAIDGGSKKEIDRKLVQWAS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  81 QRGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVH 160
Cdd:cd18067   109 QQGRRVSTPVLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVN 188

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1673538796 161 FVNSGILGTAHEFKKHFELPILKGRDAAASEADRQLGEERLRELTSIVNRCLIRR 215
Cdd:cd18067   189 FVNPGILGTAAEFKKNFELPILKGRDADASEKERQLGEEKLQELISIVNRCIIRR 243
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 2-467 2.91e-113

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


:

Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 352.22  E-value: 2.91e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   2 ADEMGLGKTLQCITLMWTLLRQSpeckpEIDKAVVVSPSSLVKNWYNEVGKWLGGrIQPLAIDGGSKDEidQKLEGFMNq 81
Cdd:COG0553   266 ADDMGLGKTIQALALLLELKERG-----LARPVLIVAPTSLVGNWQRELAKFAPG-LRVLVLDGTRERA--KGANPFED- 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  82 rgarvsSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVHF 161
Cdd:COG0553   337 ------ADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDF 410

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 162 VNSGILGTAHEFKKHFELPILKGRDAAAseadrqlgeERLRELtsiVNRCLIRRT-SDILsKYLPVKIEQVVCCRLTPLQ 240
Cdd:COG0553   411 LNPGLLGSLKAFRERFARPIEKGDEEAL---------ERLRRL---LRPFLLRRTkEDVL-KDLPEKTEETLYVELTPEQ 477

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 241 TELYKRFLRQAKpaEELLEGKMSVSSLS---SITSLKKLCNHPALIYdkcvEEEDGFVGAldlfppgysskalepqlSGK 317
Cdd:COG0553   478 RALYEAVLEYLR--RELEGAEGIRRRGLilaALTRLRQICSHPALLL----EEGAELSGR-----------------SAK 534

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 318 MLVLDYILAVTRSRsSDKVVLVSNYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPSSPDfVFMLSSKAGG 397
Cdd:COG0553   535 LEALLELLEELLAE-GEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAP-VFLISLKAGG 612

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 398 CGLNLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKTCYIYRLLSAGTIEEKIFQRQSHKKALSSCVVD 467
Cdd:COG0553   613 EGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
 
Name Accession Description Interval E-value
DEXHc_RAD54A cd18067
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ...
 1-215 7.79e-154

DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350825 [Multi-domain]  Cd Length: 243  Bit Score: 440.37  E-value: 7.79e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKPEIDKAVVVSPSSLVKNWYNEVGKWLGGRIQPLAIDGGSKDEIDQKLEGFMN 80
Cdd:cd18067    29 MADEMGLGKTLQCITLMWTLLRQSPQCKPEIDKAIVVSPSSLVKNWANELGKWLGGRLQPLAIDGGSKKEIDRKLVQWAS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  81 QRGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVH 160
Cdd:cd18067   109 QQGRRVSTPVLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVN 188

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1673538796 161 FVNSGILGTAHEFKKHFELPILKGRDAAASEADRQLGEERLRELTSIVNRCLIRR 215
Cdd:cd18067   189 FVNPGILGTAAEFKKNFELPILKGRDADASEKERQLGEEKLQELISIVNRCIIRR 243
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 2-467 2.91e-113

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 352.22  E-value: 2.91e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   2 ADEMGLGKTLQCITLMWTLLRQSpeckpEIDKAVVVSPSSLVKNWYNEVGKWLGGrIQPLAIDGGSKDEidQKLEGFMNq 81
Cdd:COG0553   266 ADDMGLGKTIQALALLLELKERG-----LARPVLIVAPTSLVGNWQRELAKFAPG-LRVLVLDGTRERA--KGANPFED- 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  82 rgarvsSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVHF 161
Cdd:COG0553   337 ------ADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDF 410

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 162 VNSGILGTAHEFKKHFELPILKGRDAAAseadrqlgeERLRELtsiVNRCLIRRT-SDILsKYLPVKIEQVVCCRLTPLQ 240
Cdd:COG0553   411 LNPGLLGSLKAFRERFARPIEKGDEEAL---------ERLRRL---LRPFLLRRTkEDVL-KDLPEKTEETLYVELTPEQ 477

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 241 TELYKRFLRQAKpaEELLEGKMSVSSLS---SITSLKKLCNHPALIYdkcvEEEDGFVGAldlfppgysskalepqlSGK 317
Cdd:COG0553   478 RALYEAVLEYLR--RELEGAEGIRRRGLilaALTRLRQICSHPALLL----EEGAELSGR-----------------SAK 534

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 318 MLVLDYILAVTRSRsSDKVVLVSNYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPSSPDfVFMLSSKAGG 397
Cdd:COG0553   535 LEALLELLEELLAE-GEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAP-VFLISLKAGG 612

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 398 CGLNLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKTCYIYRLLSAGTIEEKIFQRQSHKKALSSCVVD 467
Cdd:COG0553   613 EGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 1-283 3.77e-73

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 235.27  E-value: 3.77e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPecKPEiDKAVVVSPSSLVKNWYNEVGKWLG-GRIQPLAIDGGSKDeidqkLEGFM 79
Cdd:pfam00176  22 LADEMGLGKTLQTISLLLYLKHVDK--NWG-GPTLIVVPLSLLHNWMNEFERWVSpPALRVVVLHGNKRP-----QERWK 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  80 NQRGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLV 159
Cdd:pfam00176  94 NDPNFLADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELWALL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 160 HFVNSGILGTAHEFKKHFELPILKGrdaaaseadrqLGEERLRELTSIVNRCLIRRTSDILSKYLPVKIEQVVCCRLTPL 239
Cdd:pfam00176 174 NFLRPGPFGSLSTFRNWFDRPIERG-----------GGKKGVSRLHKLLKPFLLRRTKKDVEKSLPPKVEYILFCRLSKL 242

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1673538796 240 QTELYKRFLRQAKPAEELLEGKMSVSSLS---SITSLKKLCNHPALI 283
Cdd:pfam00176 243 QRKLYQTFLLKKDLNAIKTGEGGREIKASllnILMRLRKICNHPGLI 289
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 1-468 5.88e-67

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 235.08  E-value: 5.88e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796    1 MADEMGLGKTLQCITLMWTLLRQSPECKPEIdkavVVSPSSLVKNWYNEVGKWLgGRIQPLAIDGGSKDEIDQKlEGFMN 80
Cdd:PLN03142   193 LADEMGLGKTLQTISLLGYLHEYRGITGPHM----VVAPKSTLGNWMNEIRRFC-PVLRAVKFHGNPEERAHQR-EELLV 266

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   81 QRGARVsspiLIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVH 160
Cdd:PLN03142   267 AGKFDV----CVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLN 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  161 FVNSGILGTAHEFKKHFELpilkgrdaaASEADRQlgeERLRELTSIVNRCLIRRTSDILSKYLPVKIEQVVCCRLTPLQ 240
Cdd:PLN03142   343 FLLPEIFSSAETFDEWFQI---------SGENDQQ---EVVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQ 410

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  241 TELYKRFLRqaKPAEELLEGKMSVSSLSSITSLKKLCNHPALiydkcveeedgFVGAlDLFPPGYSSKALEPQlSGKMLV 320
Cdd:PLN03142   411 KQYYKALLQ--KDLDVVNAGGERKRLLNIAMQLRKCCNHPYL-----------FQGA-EPGPPYTTGEHLVEN-SGKMVL 475

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  321 LDYILAVTRSRSSdKVVLVSNYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPSSPDFVFMLSSKAGGCGL 400
Cdd:PLN03142   476 LDKLLPKLKERDS-RVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKFVFLLSTRAGGLGI 554

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1673538796  401 NLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKTCYIYRLLSAGTIEEKIFQRQSHKKALSSCVVDE 468
Cdd:PLN03142   555 NLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQ 622
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 314-442 4.39e-57

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 187.30  E-value: 4.39e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 314 LSGKMLVLDYILAVTRSrSSDKVVLVSNYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPSSpDFVFMLSS 393
Cdd:cd18793     9 VSGKLEALLELLEELRE-PGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPD-IRVFLLST 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1673538796 394 KAGGCGLNLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKTCYIYRLL 442
Cdd:cd18793    87 KAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 316-431 3.47e-24

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 97.28  E-value: 3.47e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 316 GKMLVLDYILavtRSRSSDKVVLVSNYTQTLDLfEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPSSPdfvFMLSSKA 395
Cdd:pfam00271   1 EKLEALLELL---KKERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKID---VLVATDV 73

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1673538796 396 GGCGLNLIGANRLVMFDPDWNPANDEQAMARVWRDG 431
Cdd:pfam00271  74 AERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEXDc smart00487
DEAD-like helicases superfamily;
1-177 1.26e-20

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 90.24  E-value: 1.26e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796    1 MADEMGLGKTLQCITLMWTLLRQSPECKpeidkAVVVSPS-SLVKNWYNEVGKWLGG-RIQPLAIDGGskDEIDQKLEGF 78
Cdd:smart00487  29 LAAPTGSGKTLAALLPALEALKRGKGGR-----VLVLVPTrELAEQWAEELKKLGPSlGLKVVGLYGG--DSKREQLRKL 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   79 MNQRgarvsSPILIISYETFRLHV--GVLQKGSVGLVICDEGHRLKNSEN--QTYQALDSLNTSRRVLI-SGTP---IQN 150
Cdd:smart00487 102 ESGK-----TDILVTTPGRLLDLLenDKLSLSNVDLVILDEAHRLLDGGFgdQLEKLLKLLPKNVQLLLlSATPpeeIEN 176

                          170       180
                   ....*....|....*....|....*..
gi 1673538796  151 DLLEYFSLVHFVNSGIlgTAHEFKKHF 177
Cdd:smart00487 177 LLELFLNDPVFIDVGF--TPLEPIEQF 201
HELICc smart00490
helicase superfamily c-terminal domain;
347-431 4.38e-19

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 81.87  E-value: 4.38e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  347 DLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPsspDFVFMLSSKAGGCGLNLIGANRLVMFDPDWNPANDEQAMAR 426
Cdd:smart00490   1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNG---KIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGR 77


                   ....*
gi 1673538796  427 VWRDG 431
Cdd:smart00490  78 AGRAG 82
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
6-210 4.51e-07

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 52.72  E-value: 4.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   6 GLGKTlqcITLMWTLLRQSpeckpEIDKAVVVSPS-SLVKNWYNEVGKWLGgriqpLAIDGGSKDEIDqklegfmnqrga 84
Cdd:COG1061   110 GTGKT---VLALALAAELL-----RGKRVLVLVPRrELLEQWAEELRRFLG-----DPLAGGGKKDSD------------ 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  85 rvsSPILIISYETF--RLHVGVLQKgSVGLVICDEGHRLknSENQTYQALDSLNTSRRVLISGTPIQND----LLEYF-- 156
Cdd:COG1061   165 ---APITVATYQSLarRAHLDELGD-RFGLVIIDEAHHA--GAPSYRRILEAFPAAYRLGLTATPFRSDgreiLLFLFdg 238

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1673538796 157 -----SLVHFVNSGILGTAHEFKKHFELPILKGRDAAASEADRQL---GEER-LRELTSIVNR 210
Cdd:COG1061   239 ivyeySLKEAIEDGYLAPPEYYGIRVDLTDERAEYDALSERLREAlaaDAERkDKILRELLRE 301
DpdE NF041062
protein DpdE;
2-163 1.59e-05

protein DpdE;


Pssm-ID: 468989 [Multi-domain]  Cd Length: 1048  Bit Score: 48.04  E-value: 1.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796    2 ADEMGLGKTLQ-CITLMWTLLRqspecKPEiDKAVVVSPSSLVKNWynevgkwlggriqplaidggsKDEIDQK--LEGF 78
Cdd:NF041062   176 ADEVGLGKTIEaGLVIRQHLLD-----NPD-ARVLVLVPDALVRQW---------------------RRELRDKffLDDF 228

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   79 MNQRgarvsspILIISYETFRlhvGVLQKGSV-GLVICDEGHRL-------KNSENQTYQALDSL--NTSRRVLISGTPI 148
Cdd:NF041062   229 PGAR-------VRVLSHEEPE---RWEPLLDApDLLVVDEAHQLarlawsgDPPERARYRELAALahAAPRLLLLSATPV 298

                          170
                   ....*....|....*
gi 1673538796  149 QNDLLEYFSLVHFVN 163
Cdd:NF041062   299 LGNEETFLALLHLLD 313
 
Name Accession Description Interval E-value
DEXHc_RAD54A cd18067
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ...
 1-215 7.79e-154

DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350825 [Multi-domain]  Cd Length: 243  Bit Score: 440.37  E-value: 7.79e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKPEIDKAVVVSPSSLVKNWYNEVGKWLGGRIQPLAIDGGSKDEIDQKLEGFMN 80
Cdd:cd18067    29 MADEMGLGKTLQCITLMWTLLRQSPQCKPEIDKAIVVSPSSLVKNWANELGKWLGGRLQPLAIDGGSKKEIDRKLVQWAS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  81 QRGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVH 160
Cdd:cd18067   109 QQGRRVSTPVLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVN 188

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1673538796 161 FVNSGILGTAHEFKKHFELPILKGRDAAASEADRQLGEERLRELTSIVNRCLIRR 215
Cdd:cd18067   189 FVNPGILGTAAEFKKNFELPILKGRDADASEKERQLGEEKLQELISIVNRCIIRR 243
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 2-467 2.91e-113

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 352.22  E-value: 2.91e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   2 ADEMGLGKTLQCITLMWTLLRQSpeckpEIDKAVVVSPSSLVKNWYNEVGKWLGGrIQPLAIDGGSKDEidQKLEGFMNq 81
Cdd:COG0553   266 ADDMGLGKTIQALALLLELKERG-----LARPVLIVAPTSLVGNWQRELAKFAPG-LRVLVLDGTRERA--KGANPFED- 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  82 rgarvsSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVHF 161
Cdd:COG0553   337 ------ADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDF 410

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 162 VNSGILGTAHEFKKHFELPILKGRDAAAseadrqlgeERLRELtsiVNRCLIRRT-SDILsKYLPVKIEQVVCCRLTPLQ 240
Cdd:COG0553   411 LNPGLLGSLKAFRERFARPIEKGDEEAL---------ERLRRL---LRPFLLRRTkEDVL-KDLPEKTEETLYVELTPEQ 477

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 241 TELYKRFLRQAKpaEELLEGKMSVSSLS---SITSLKKLCNHPALIYdkcvEEEDGFVGAldlfppgysskalepqlSGK 317
Cdd:COG0553   478 RALYEAVLEYLR--RELEGAEGIRRRGLilaALTRLRQICSHPALLL----EEGAELSGR-----------------SAK 534

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 318 MLVLDYILAVTRSRsSDKVVLVSNYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPSSPDfVFMLSSKAGG 397
Cdd:COG0553   535 LEALLELLEELLAE-GEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAP-VFLISLKAGG 612

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 398 CGLNLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKTCYIYRLLSAGTIEEKIFQRQSHKKALSSCVVD 467
Cdd:COG0553   613 EGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
DEXHc_RAD54 cd18004
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ...
 1-215 2.98e-108

DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350762 [Multi-domain]  Cd Length: 240  Bit Score: 323.85  E-value: 2.98e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKPEIDKAVVVSPSSLVKNWYNEVGKWLG-GRIQPLAIDGGSKDEIDQKLegfm 79
Cdd:cd18004    29 LADEMGLGKTLQAIALVWTLLKQGPYGKPTAKKALIVCPSSLVGNWKAEFDKWLGlRRIKVVTADGNAKDVKASLD---- 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  80 nQRGARVSSPILIISYETFRLHVGVLQKG-SVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSL 158
Cdd:cd18004   105 -FFSSASTYPVLIISYETLRRHAEKLSKKiSIDLLICDEGHRLKNSESKTTKALNSLPCRRRLLLTGTPIQNDLDEFFAL 183

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1673538796 159 VHFVNSGILGTAHEFKKHFELPILKGRDAAASEADRQLGEERLRELTSIVNRCLIRR 215
Cdd:cd18004   184 VDFVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSQELSELTSRFILRR 240
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 1-283 3.77e-73

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 235.27  E-value: 3.77e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPecKPEiDKAVVVSPSSLVKNWYNEVGKWLG-GRIQPLAIDGGSKDeidqkLEGFM 79
Cdd:pfam00176  22 LADEMGLGKTLQTISLLLYLKHVDK--NWG-GPTLIVVPLSLLHNWMNEFERWVSpPALRVVVLHGNKRP-----QERWK 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  80 NQRGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLV 159
Cdd:pfam00176  94 NDPNFLADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELWALL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 160 HFVNSGILGTAHEFKKHFELPILKGrdaaaseadrqLGEERLRELTSIVNRCLIRRTSDILSKYLPVKIEQVVCCRLTPL 239
Cdd:pfam00176 174 NFLRPGPFGSLSTFRNWFDRPIERG-----------GGKKGVSRLHKLLKPFLLRRTKKDVEKSLPPKVEYILFCRLSKL 242

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1673538796 240 QTELYKRFLRQAKPAEELLEGKMSVSSLS---SITSLKKLCNHPALI 283
Cdd:pfam00176 243 QRKLYQTFLLKKDLNAIKTGEGGREIKASllnILMRLRKICNHPGLI 289
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 1-468 5.88e-67

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 235.08  E-value: 5.88e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796    1 MADEMGLGKTLQCITLMWTLLRQSPECKPEIdkavVVSPSSLVKNWYNEVGKWLgGRIQPLAIDGGSKDEIDQKlEGFMN 80
Cdd:PLN03142   193 LADEMGLGKTLQTISLLGYLHEYRGITGPHM----VVAPKSTLGNWMNEIRRFC-PVLRAVKFHGNPEERAHQR-EELLV 266

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   81 QRGARVsspiLIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVH 160
Cdd:PLN03142   267 AGKFDV----CVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLN 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  161 FVNSGILGTAHEFKKHFELpilkgrdaaASEADRQlgeERLRELTSIVNRCLIRRTSDILSKYLPVKIEQVVCCRLTPLQ 240
Cdd:PLN03142   343 FLLPEIFSSAETFDEWFQI---------SGENDQQ---EVVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQ 410

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  241 TELYKRFLRqaKPAEELLEGKMSVSSLSSITSLKKLCNHPALiydkcveeedgFVGAlDLFPPGYSSKALEPQlSGKMLV 320
Cdd:PLN03142   411 KQYYKALLQ--KDLDVVNAGGERKRLLNIAMQLRKCCNHPYL-----------FQGA-EPGPPYTTGEHLVEN-SGKMVL 475

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  321 LDYILAVTRSRSSdKVVLVSNYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPSSPDFVFMLSSKAGGCGL 400
Cdd:PLN03142   476 LDKLLPKLKERDS-RVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKFVFLLSTRAGGLGI 554

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1673538796  401 NLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKTCYIYRLLSAGTIEEKIFQRQSHKKALSSCVVDE 468
Cdd:PLN03142   555 NLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQ 622
DEXHc_RAD54B cd18066
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ...
 1-215 1.16e-66

DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350824 [Multi-domain]  Cd Length: 235  Bit Score: 216.25  E-value: 1.16e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPE-CKPEIDKAVVVSPSSLVKNWYNEVGKWLGG-RIQPLAIDGgskdeiDQKLEGF 78
Cdd:cd18066    29 LADEMGLGKTLQCISLIWTLLRQGPYgGKPVIKRALIVTPGSLVKNWKKEFQKWLGSeRIKVFTVDQ------DHKVEEF 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  79 MNqrgARVSSpILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSL 158
Cdd:cd18066   103 IA---SPLYS-VLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTTTALTSLSCERRIILTGTPIQNDLQEFFAL 178

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1673538796 159 VHFVNSGILGTAHEFKKHFELPILKGRDAAASEADRQLGEERLRELTSIVNRCLIRR 215
Cdd:cd18066   179 IDFVNPGILGSLSTYRKVYEEPIVRSREPTATPEEKKLGEARAAELTRLTGLFILRR 235
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 314-442 4.39e-57

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 187.30  E-value: 4.39e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 314 LSGKMLVLDYILAVTRSrSSDKVVLVSNYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPSSpDFVFMLSS 393
Cdd:cd18793     9 VSGKLEALLELLEELRE-PGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPD-IRVFLLST 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1673538796 394 KAGGCGLNLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKTCYIYRLL 442
Cdd:cd18793    87 KAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
DEXHc_Snf cd17919
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ...
 2-163 7.04e-53

DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350677 [Multi-domain]  Cd Length: 182  Bit Score: 178.14  E-value: 7.04e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   2 ADEMGLGKTLQCITLMWTLLRQSPECKPeidkAVVVSPSSLVKNWYNEVGKWLGGrIQPLAIDGGSKDEIDQKlegfmnQ 81
Cdd:cd17919    25 ADEMGLGKTLQAIAFLAYLLKEGKERGP----VLVVCPLSVLENWEREFEKWTPD-LRVVVYHGSQRERAQIR------A 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  82 RGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVHF 161
Cdd:cd17919    94 KEKLDKFDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPLQNNLEELWALLDF 173


                  ..
gi 1673538796 162 VN 163
Cdd:cd17919   174 LD 175
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
 1-200 7.17e-48

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 166.70  E-value: 7.17e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKpeidKAVVVSPSSLVKNWYNEVGKWLGGRIQPLAI---DGGSKDEiDQKLEG 77
Cdd:cd18007    31 LAHTMGLGKTLQVITFLHTYLAAAPRRS----RPLVLCPASTLYNWEDEFKKWLPPDLRPLLVlvsLSASKRA-DARLRK 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  78 FMN--QRGArvsspILIISYETFR--------------LHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRV 141
Cdd:cd18007   106 INKwhKEGG-----VLLIGYELFRnlasnattdprlkqEFIAALLDPGPDLLVLDEGHRLKNEKSQLSKALSKVKTKRRI 180

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1673538796 142 LISGTPIQNDLLEYFSLVHFVNSGILGTAHEFKKHFELPILKGRDAAASEADRQLGEER 200
Cdd:cd18007   181 LLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKPIEAGQCVDSTEEDVRLMLKR 239
DEXHc_ERCC6L2 cd18005
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ...
 1-215 1.25e-44

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350763 [Multi-domain]  Cd Length: 245  Bit Score: 158.31  E-value: 1.25e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLL------RQSPECKPEIDK----------AVVVSPSSLVKNWYNEVGKWlgGRIQPLAID 64
Cdd:cd18005    24 LGDDMGLGKTVQVIAFLAAVLgktgtrRDRENNRPRFKKkppassakkpVLIVAPLSVLYNWKDELDTW--GHFEVGVYH 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  65 GGSKDEIdqkLEGFMNQRGARVsspiLIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLIS 144
Cdd:cd18005   102 GSRKDDE---LEGRLKAGRLEV----VVTTYDTLRRCIDSLNSINWSAVIADEAHRIKNPKSKLTQAMKELKCKVRIGLT 174

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1673538796 145 GTPIQNDLLEYFSLVHFVNSGILGTAHEFKKHFELPILKGRDAAASEADRQLGEERLRELTSIVNRCLIRR 215
Cdd:cd18005   175 GTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATARELRLGRKRKQELAVKLSKFFLRR 245
DEXHc_ERCC6L cd18001
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ...
 1-215 1.90e-39

DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350759 [Multi-domain]  Cd Length: 232  Bit Score: 143.67  E-value: 1.90e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSpeckpEIDKAVVVSPSSLVKNWYNEVGKWlGGRIQPLAIDGGSKDEIDQKLEGFMN 80
Cdd:cd18001    24 LADDMGLGKTVQICAFLSGMFDSG-----LIKSVLVVMPTSLIPHWVKEFAKW-TPGLRVKVFHGTSKKERERNLERIQR 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  81 QRGarvsspILIISYETFRLHVGVLQKGSVG-----LVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEY 155
Cdd:cd18001    98 GGG------VLLTTYGMVLSNTEQLSADDHDefkwdYVILDEGHKIKNSKTKSAKSLREIPAKNRIILTGTPIQNNLKEL 171

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1673538796 156 FSLVHFV-NSGILGTAHEFKKHFELPILKGRDAAASEADRQLGEERLRELTSIVNRCLIRR 215
Cdd:cd18001   172 WALFDFAcNGSLLGTRKTFKMEFENPITRGRDKDATQGEKALGSEVAENLRQIIKPYFLRR 232
DEXHc_ARIP4 cd18069
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ...
 1-200 7.26e-38

DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350827 [Multi-domain]  Cd Length: 227  Bit Score: 139.57  E-value: 7.26e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPeckpeIDKAVVVSPSSLVKNWYNEVGKWL-----GGRIQPLAID----GGSKDEI 71
Cdd:cd18069    33 LAHSMGLGKTLQVISFLDVLLRHTG-----AKTVLAIVPVNTLQNWLSEFNKWLpppeaLPNVRPRPFKvfilNDEHKTT 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  72 DQKLEGFMNQRGarvSSPILIISYETFRLHVGVlqkgsvGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQND 151
Cdd:cd18069   108 AARAKVIEDWVK---DGGVLLMGYEMFRLRPGP------DVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNN 178

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1673538796 152 LLEYFSLVHFVNSGILGTAHEFKKHFELPILKGRDAAASEADRQLGEER 200
Cdd:cd18069   179 LIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCVDSTPQDVKLMRYR 227
DEXHc_Mot1 cd17999
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ...
 1-215 1.75e-37

DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350757 [Multi-domain]  Cd Length: 232  Bit Score: 138.64  E-value: 1.75e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQ--CITLMWTLLRQSpECKPEIDKAVVVSPSSLVKNWYNEVGKWLG-GRIQPLAIDGGSKDeiDQKLEG 77
Cdd:cd17999    24 LCDDMGLGKTLQtlCILASDHHKRAN-SFNSENLPSLVVCPPTLVGHWVAEIKKYFPnAFLKPLAYVGPPQE--RRRLRE 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  78 FMNQrgarvsSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFS 157
Cdd:cd17999   101 QGEK------HNVIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKANHRLILSGTPIQNNVLELWS 174

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1673538796 158 LVHFVNSGILGTAHEFKKHFELPILKGRDAAASEADRQLGEERLRELTSIVNRCLIRR 215
Cdd:cd17999   175 LFDFLMPGYLGTEKQFQRRFLKPILASRDSKASAKEQEAGALALEALHKQVLPFLLRR 232
DEXQc_arch_SWI2_SNF2 cd18012
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ...
 2-216 5.60e-37

DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350770 [Multi-domain]  Cd Length: 218  Bit Score: 136.54  E-value: 5.60e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   2 ADEMGLGKTLQCITLMwTLLRQSPECKPeidkAVVVSPSSLVKNWYNEVGKWlggriQP----LAIDG-GSKDEIDQKLE 76
Cdd:cd18012    29 ADDMGLGKTLQTLALL-LSRKEEGRKGP----SLVVAPTSLIYNWEEEAAKF-----APelkvLVIHGtKRKREKLRALE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  77 GFmnqrgarvssPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYF 156
Cdd:cd18012    99 DY----------DLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTPIENHLGELW 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 157 SLVHFVNSGILGTAHEFKKHFELPILKGRDaaaseadrqlgEERLRELTSIVNRCLIRRT 216
Cdd:cd18012   169 SIFDFLNPGLLGSYKRFKKRFAKPIEKDGD-----------EEALEELKKLISPFILRRL 217
DEXHc_ATRX cd18068
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ...
 1-200 9.58e-36

DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350826 [Multi-domain]  Cd Length: 246  Bit Score: 134.25  E-value: 9.58e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQspECKPEIDKAVVVSPSSLVKNWYNEVGKWLGGRIQPLAIDGGSKDEIDQKLE-GFM 79
Cdd:cd18068    33 LAHCMGLGKTLQVVTFLHTVLLC--EKLENFSRVLVVCPLNTVLNWLNEFEKWQEGLKDEEKIEVNELATYKRPQErSYK 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  80 NQRGARVSSpILIISYETFR-LHVG---------------VLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLI 143
Cdd:cd18068   111 LQRWQEEGG-VMIIGYDMYRiLAQErnvksreklkeifnkALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRTKRRIVL 189

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1673538796 144 SGTPIQNDLLEYFSLVHFVNSGILGTAHEFKKHFELPILKGRDAAASEADRQLGEER 200
Cdd:cd18068   190 TGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQNGQCADSTLVDVRVMKKR 246
DEXHc_HELLS_SMARCA6 cd18009
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ...
 1-215 5.64e-33

DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350767 [Multi-domain]  Cd Length: 236  Bit Score: 125.96  E-value: 5.64e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMwTLLRQSPECKPeidkAVVVSPSSLVKNWYNEVGKWLGGriQPLAIDGGSKDEIDQKLEGFMN 80
Cdd:cd18009    27 LADEMGLGKTIQTIALL-AHLRERGVWGP----FLVIAPLSTLPNWVNEFARFTPS--VPVLLYHGTKEERERLRKKIMK 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  81 QRGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVH 160
Cdd:cd18009   100 REGTLQDFPVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRLLLTGTPLQNNLSELWSLLN 179

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1673538796 161 FVNSGILGTAHEFKKHFELPILKGRDAAASEADRQLGEERLRELTSIVNRCLIRR 215
Cdd:cd18009   180 FLLPDVFDDLSSFESWFDFSSLSDNAADISNLSEEREQNIVHMLHAILKPFLLRR 234
DEXDc_SHPRH-like cd18008
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ...
 1-215 1.53e-29

DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350766 [Multi-domain]  Cd Length: 241  Bit Score: 116.62  E-value: 1.53e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKPEIDKAV-------------VVSPSSLVKNWYNEVGK-WLGGRIQPLAIDGG 66
Cdd:cd18008    19 LADEMGLGKTIQALALILATRPQDPKIPEELEENSsdpkklylskttlIVVPLSLLSQWKDEIEKhTKPGSLKVYVYHGS 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  67 SKDEIDQKLEGFMnqrgarvsspILIISYETFRLHVGVLQKGSVGL----------------VICDEGHRLKNSENQTYQ 130
Cdd:cd18008    99 KRIKSIEELSDYD----------IVITTYGTLASEFPKNKKGGGRDskekeasplhrirwyrVILDEAHNIKNRSTKTSR 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 131 ALDSLNTSRRVLISGTPIQNDLLEYFSLVHFVNSGILGTAHEFKKHFELPILKGRDAAaseadrqlgeerLRELTSIVNR 210
Cdd:cd18008   169 AVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPFSKNDRKA------------LERLQALLKP 236


                  ....*
gi 1673538796 211 CLIRR 215
Cdd:cd18008   237 ILLRR 241
DEXQc_SRCAP cd18003
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ...
 1-215 1.66e-29

DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350761 [Multi-domain]  Cd Length: 223  Bit Score: 115.91  E-value: 1.66e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKPEIdkavVVSPSSLVKNWYNEVGKWLGGriqpLAIDG--GSKDEIDQKLEGF 78
Cdd:cd18003    24 LADEMGLGKTIQTIALLAHLACEKGNWGPHL----IVVPTSVMLNWEMEFKRWCPG----FKILTyyGSAKERKLKRQGW 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  79 MNQRgarvSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSL 158
Cdd:cd18003    96 MKPN----SFHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTPLQNSLMELWSL 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1673538796 159 VHFVNSGILGTAHEFKKHFELPIlkgrdAAASEADRQLGEERLRELTSIVNRCLIRR 215
Cdd:cd18003   172 MHFLMPHIFQSHQEFKEWFSNPL-----TAMSEGSQEENEELVRRLHKVLRPFLLRR 223
DEXHc_CHD6_7_8_9 cd17995
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ...
 1-177 1.17e-28

DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350753 [Multi-domain]  Cd Length: 223  Bit Score: 113.50  E-value: 1.17e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMwTLLRQSPECKPEIdkaVVVSPSSLVKNWYNEVGKWLGGRiqplAI---DGGSKDEIDQKLEG 77
Cdd:cd17995    24 LADEMGLGKTIQSIAFL-EHLYQVEGIRGPF---LVIAPLSTIPNWQREFETWTDMN----VVvyhGSGESRQIIQQYEM 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  78 FMNQRGARVSSP-----ILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDL 152
Cdd:cd17995    96 YFKDAQGRKKKGvykfdVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLKKLTLEHKLLLTGTPLQNNT 175

                         170       180
                  ....*....|....*....|....*
gi 1673538796 153 LEYFSLVHFVNSGILGTAHEFKKHF 177
Cdd:cd17995   176 EELWSLLNFLEPEKFPSSEEFLEEF 200
DEXHc_HARP_SMARCAL1 cd18010
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ...
 2-215 2.23e-25

DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350768 [Multi-domain]  Cd Length: 213  Bit Score: 104.21  E-value: 2.23e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   2 ADEMGLGKTLQCITLM------WTLLrqspeckpeidkavVVSPSSLVKNWYNEVGKWLggriqplaiDGGSKDEIdQKL 75
Cdd:cd18010    22 ADEMGLGKTVQAIAIAayyreeWPLL--------------IVCPSSLRLTWADEIERWL---------PSLPPDDI-QVI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  76 EGfmNQRGARVSSP-ILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSL--NTSRRVLISGTPIQNDL 152
Cdd:cd18010    78 VK--SKDGLRDGDAkVVIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPLlkRAKRVILLSGTPALSRP 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1673538796 153 LEYFSLVHFVNSGILGTAHEFKKHFELPILKGRDAAASeadrqlGEERLRELTSIV-NRCLIRR 215
Cdd:cd18010   156 IELFTQLDALDPKLFGRFHDFGRRYCAAKQGGFGWDYS------GSSNLEELHLLLlATIMIRR 213
DEXHc_CHD1_2 cd17993
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ...
 1-162 1.22e-24

DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350751 [Multi-domain]  Cd Length: 218  Bit Score: 102.05  E-value: 1.22e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKPEIdkavVVSPSSLVKNWYNEVGKW---------LGgriqplaiDGGSKDEI 71
Cdd:cd17993    25 LADEMGLGKTVQTISFLSYLFHSQQQYGPFL----VVVPLSTMPAWQREFAKWapdmnvivyLG--------DIKSRDTI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  72 dQKLEgFMNQRGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQND 151
Cdd:cd17993    93 -REYE-FYFSQTKKLKFNVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNNRLLITGTPLQNS 170

                         170
                  ....*....|.
gi 1673538796 152 LLEYFSLVHFV 162
Cdd:cd17993   171 LKELWALLHFL 181
DEXHc_ERCC6 cd18000
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ...
 1-162 2.41e-24

DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350758 [Multi-domain]  Cd Length: 193  Bit Score: 100.48  E-value: 2.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLmwtlLRQSPECKPEIDKAVVVSPSSLVKNWYNEVGKWLGG-RIQPL---AIDGGSKDEIDQKLE 76
Cdd:cd18000    24 LGDEMGLGKTIQIIAF----LAALHHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPfRVVVLhssGSGTGSEEKLGSIER 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  77 GFMNQRGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYF 156
Cdd:cd18000   100 KSQLIRKVVGDGGILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDAEITLACKQLRTPHRLILSGTPIQNNLKELW 179


                  ....*.
gi 1673538796 157 SLVHFV 162
Cdd:cd18000   180 SLFDFV 185
DEXHc_SMARCA1_SMARCA5 cd17997
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ...
 1-216 3.31e-24

DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350755 [Multi-domain]  Cd Length: 222  Bit Score: 100.86  E-value: 3.31e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKPEIdkavVVSPSSLVKNWYNEVGKWLGG-RIQPLAidgGSKDEIDQklegFM 79
Cdd:cd17997    27 LADEMGLGKTLQTISLLGYLKHYKNINGPHL----IIVPKSTLDNWMREFKRWCPSlRVVVLI---GDKEERAD----II 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  80 NQRGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLV 159
Cdd:cd17997    96 RDVLLPGKFDVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTGTPLQNNLHELWALL 175

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1673538796 160 HFVNSGILGTAHEFKKHFELpilkgrdaaasEADRQLGEERLRELTSIVNRCLIRRT 216
Cdd:cd17997   176 NFLLPDVFTSSEDFDEWFNV-----------NNCDDDNQEVVQRLHKVLRPFLLRRI 221
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 316-431 3.47e-24

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 97.28  E-value: 3.47e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 316 GKMLVLDYILavtRSRSSDKVVLVSNYTQTLDLfEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPSSPdfvFMLSSKA 395
Cdd:pfam00271   1 EKLEALLELL---KKERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKID---VLVATDV 73

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1673538796 396 GGCGLNLIGANRLVMFDPDWNPANDEQAMARVWRDG 431
Cdd:pfam00271  74 AERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEXQc_INO80 cd18002
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ...
 1-215 1.15e-23

DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350760 [Multi-domain]  Cd Length: 229  Bit Score: 99.50  E-value: 1.15e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKPeidkAVVVSPSSLVKNWYNEVGKWLGgRIQPLAIDGGSKD-EIDQKLEGFM 79
Cdd:cd18002    24 LADEMGLGKTVQSIAVLAHLAEEHNIWGP----FLVIAPASTLHNWQQEISRFVP-QFKVLPYWGNPKDrKVLRKFWDRK 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  80 NQRGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLV 159
Cdd:cd18002    99 NLYTRDAPFHVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRLLLTGTPIQNSMAELWALL 178

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1673538796 160 HFVNSGILGTAHEFKKHFELPIlkgrdAAASEADRQLGEERLRELTSIVNRCLIRR 215
Cdd:cd18002   179 HFIMPTLFDSHDEFNEWFSKDI-----ESHAENKTGLNEHQLKRLHMILKPFMLRR 229
DEXHc_SMARCAD1 cd17998
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ...
 1-162 1.12e-22

DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350756 [Multi-domain]  Cd Length: 187  Bit Score: 95.53  E-value: 1.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMwTLLRQSPECKPEIdkavVVSPSSLVKNWYNEVGKWLGG-RIQPLAidgGSKDE-------ID 72
Cdd:cd17998    24 LADEMGLGKTIQVIAFL-AYLKEIGIPGPHL----VVVPSSTLDNWLREFKRWCPSlKVEPYY---GSQEErkhlrydIL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  73 QKLEGFmnqrgarvssPILIISYE---TFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQ 149
Cdd:cd17998    96 KGLEDF----------DVIVTTYNlatSNPDDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLLTGTPLQ 165

                         170
                  ....*....|...
gi 1673538796 150 NDLLEYFSLVHFV 162
Cdd:cd17998   166 NNLLELMSLLNFI 178
DEXHc_CHD2 cd18054
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ...
 1-186 9.15e-22

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350812 [Multi-domain]  Cd Length: 237  Bit Score: 94.30  E-value: 9.15e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKPeidkAVVVSPSSLVKNWYNEVGKWLGGRIQPLAI-DGGSKDEIDQKleGFM 79
Cdd:cd18054    44 LADEMGLGKTIQTISFLSYLFHQHQLYGP----FLLVVPLSTLTSWQREFEIWAPEINVVVYIgDLMSRNTIREY--EWI 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  80 NQRGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLV 159
Cdd:cd18054   118 HSQTKRLKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLL 197

                         170       180
                  ....*....|....*....|....*..
gi 1673538796 160 HFvnsgILGTAHEFKKHFELPILKGRD 186
Cdd:cd18054   198 HF----IMPEKFEFWEDFEEDHGKGRE 220
DEXHc_SMARCA2_SMARCA4 cd17996
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ...
 1-215 3.37e-21

DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350754 [Multi-domain]  Cd Length: 233  Bit Score: 92.82  E-value: 3.37e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLrqspECKPEIDKAVVVSPSSLVKNWYNEVGKWLggriqPLAIDGGSKDEIDQKLEGFMN 80
Cdd:cd17996    27 LADEMGLGKTIQTISLITYLM----EKKKNNGPYLVIVPLSTLSNWVSEFEKWA-----PSVSKIVYKGTPDVRKKLQSQ 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  81 QRGARVSspILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDS-LNTSRRVLISGTPIQNDLLEYFSLV 159
Cdd:cd17996    98 IRAGKFN--VLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTyYHARYRLLLTGTPLQNNLPELWALL 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1673538796 160 HFVNSGILGTAHEFKKHFELPIlkgrdAAASEADR-QLGEER----LRELTSIVNRCLIRR 215
Cdd:cd17996   176 NFLLPKIFKSCKTFEQWFNTPF-----ANTGEQVKiELNEEEtlliIRRLHKVLRPFLLRR 231
DEXDc smart00487
DEAD-like helicases superfamily;
1-177 1.26e-20

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 90.24  E-value: 1.26e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796    1 MADEMGLGKTLQCITLMWTLLRQSPECKpeidkAVVVSPS-SLVKNWYNEVGKWLGG-RIQPLAIDGGskDEIDQKLEGF 78
Cdd:smart00487  29 LAAPTGSGKTLAALLPALEALKRGKGGR-----VLVLVPTrELAEQWAEELKKLGPSlGLKVVGLYGG--DSKREQLRKL 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   79 MNQRgarvsSPILIISYETFRLHV--GVLQKGSVGLVICDEGHRLKNSEN--QTYQALDSLNTSRRVLI-SGTP---IQN 150
Cdd:smart00487 102 ESGK-----TDILVTTPGRLLDLLenDKLSLSNVDLVILDEAHRLLDGGFgdQLEKLLKLLPKNVQLLLlSATPpeeIEN 176

                          170       180
                   ....*....|....*....|....*..
gi 1673538796  151 DLLEYFSLVHFVNSGIlgTAHEFKKHF 177
Cdd:smart00487 177 LLELFLNDPVFIDVGF--TPLEPIEQF 201
DEXHc_CHD1L cd18006
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ...
 1-215 8.29e-20

DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350764 [Multi-domain]  Cd Length: 216  Bit Score: 88.26  E-value: 8.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKPEIdkavVVSPSSLVKNWYNEVGKWlGGRIQPLAIDGGSKDEIDQklegfmn 80
Cdd:cd18006    24 LGDEMGLGKTCQTISLLWYLAGRLKLLGPFL----VLCPLSVLDNWKEELNRF-APDLSVITYMGDKEKRLDL------- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  81 QRGARVSSP--ILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSL 158
Cdd:cd18006    92 QQDIKSTNRfhVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTPIQNSLQELYAL 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1673538796 159 VHFVNSGILG--TAHEFKKHFelpilkgrdaaaseADRQLGEERLRELTSIVNRCLIRR 215
Cdd:cd18006   172 LSFIEPNVFPkdKLDDFIKAY--------------SETDDESETVEELHLLLQPFLLRR 216
DEXHc_CHD8 cd18060
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ...
 1-215 3.29e-19

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350818 [Multi-domain]  Cd Length: 222  Bit Score: 86.65  E-value: 3.29e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITL---MWTLLRQSPeckpeidkAVVVSPSSLVKNWYNEVGKWLggRIQPLAIDGG-SKDEIDQKLE 76
Cdd:cd18060    24 LADEMGLGKTIQSIAFlqeVYNVGIHGP--------FLVIAPLSTITNWEREFNTWT--EMNTIVYHGSlASRQMIQQYE 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  77 GFMNQRGARV-----SSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQND 151
Cdd:cd18060    94 MYCKDSRGRLipgayKFDALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNT 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1673538796 152 LLEYFSLVHFVNSGILGTAHEFKKHFelpilkgrdaaaseADRQLgEERLRELTSIVNRCLIRR 215
Cdd:cd18060   174 VEELFSLLHFLEPSQFPSESEFLKDF--------------GDLKT-EEQVQKLQAILKPMMLRR 222
HELICc smart00490
helicase superfamily c-terminal domain;
347-431 4.38e-19

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 81.87  E-value: 4.38e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  347 DLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPsspDFVFMLSSKAGGCGLNLIGANRLVMFDPDWNPANDEQAMAR 426
Cdd:smart00490   1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNG---KIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGR 77


                   ....*
gi 1673538796  427 VWRDG 431
Cdd:smart00490  78 AGRAG 82
DEXHc_SMARCA5 cd18064
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ...
 1-227 6.54e-19

DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350822 [Multi-domain]  Cd Length: 244  Bit Score: 86.26  E-value: 6.54e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKPEIdkavVVSPSSLVKNWYNEVGKWLGgRIQPLAIDGGSKdeidqklegfmn 80
Cdd:cd18064    39 LADEMGLGKTLQTISLLGYMKHYRNIPGPHM----VLVPKSTLHNWMAEFKRWVP-TLRAVCLIGDKD------------ 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  81 QRGARVSSPIL-------IISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLL 153
Cdd:cd18064   102 QRAAFVRDVLLpgewdvcVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLH 181

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1673538796 154 EYFSLVHFVNSGILGTAHEFKKHFelpilkgrdaaasEADRQLGEERLRELTSIVNR-CLIRRTSDILSKYLPVK 227
Cdd:cd18064   182 ELWALLNFLLPDVFNSAEDFDSWF-------------DTNNCLGDQKLVERLHMVLRpFLLRRIKADVEKSLPPK 243
DEXHc_CHD3 cd18055
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ...
 1-177 9.90e-18

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350813 [Multi-domain]  Cd Length: 232  Bit Score: 82.75  E-value: 9.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKPeidkAVVVSPSSLVKNWYNEVGKW---------LGGR------------IQ 59
Cdd:cd18055    24 LADEMGLGKTIQTIVFLYSLYKEGHTKGP----FLVSAPLSTIINWEREFQMWapdfyvvtyTGDKdsraiirenefsFD 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  60 PLAIDGGSKdeidqkleGFMNQRGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSR 139
Cdd:cd18055   100 DNAVKGGKK--------AFKMKREAQVKFHVLLTSYELVTIDQAALGSIRWACLVVDEAHRLKNNQSKFFRVLNGYKIDH 171

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1673538796 140 RVLISGTPIQNDLLEYFSLVHFVNSGILGTAHEFKKHF 177
Cdd:cd18055   172 KLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEF 209
DEXHc_CHD5 cd18057
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ...
 1-177 1.56e-17

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350815 [Multi-domain]  Cd Length: 232  Bit Score: 82.03  E-value: 1.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKPEIdkavVVSPSSLVKNWYNEVGKWLGG-RIQPLAIDGGSKDEIDQKLEGFM 79
Cdd:cd18057    24 LADEMGLGKTVQTIVFLYSLYKEGHSKGPYL----VSAPLSTIINWEREFEMWAPDfYVVTYTGDKESRSVIRENEFSFE 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  80 N------------QRGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTP 147
Cdd:cd18057   100 DnairsgkkvfrmKKEAQIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTP 179

                         170       180       190
                  ....*....|....*....|....*....|
gi 1673538796 148 IQNDLLEYFSLVHFVNSGILGTAHEFKKHF 177
Cdd:cd18057   180 LQNNLEELFHLLNFLTPERFNNLEGFLEEF 209
DEXHc_CHD1 cd18053
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ...
 1-202 2.08e-17

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350811 [Multi-domain]  Cd Length: 237  Bit Score: 81.63  E-value: 2.08e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKPeidkAVVVSPSSLVKNWYNEVGKWlGGRIQPLAIDGGSKDEIDQKLEGFMN 80
Cdd:cd18053    44 LADEMGLGKTIQTISFLNYLFHEHQLYGP----FLLVVPLSTLTSWQREIQTW-APQMNAVVYLGDINSRNMIRTHEWMH 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  81 QRGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVH 160
Cdd:cd18053   119 PQTKRLKFNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLH 198

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1673538796 161 FVNSGILGTAHEFKKHFElpilKGRDAAASEADRQLGEERLR 202
Cdd:cd18053   199 FIMPEKFSSWEDFEEEHG----KGREYGYASLHKELEPFLLR 236
DEXHc_SMARCA2 cd18063
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ...
 1-215 2.89e-17

DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350821 [Multi-domain]  Cd Length: 251  Bit Score: 81.65  E-value: 2.89e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKPEIdkavVVSPSSLVKNWYNEVGKWLGG--RIQPLAIDGGSKDEIDQKLEGF 78
Cdd:cd18063    47 LADEMGLGKTIQTIALITYLMEHKRLNGPYL----IIVPLSTLSNWTYEFDKWAPSvvKISYKGTPAMRRSLVPQLRSGK 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  79 MNqrgarvsspILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTS-RRVLISGTPIQNDLLEYFS 157
Cdd:cd18063   123 FN---------VLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVApRRILLTGTPLQNKLPELWA 193

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1673538796 158 LVHFVNSGILGTAHEFKKHFELPI-LKGRDAAASEADRQLgeeRLRELTSIVNRCLIRR 215
Cdd:cd18063   194 LLNFLLPTIFKSCSTFEQWFNAPFaMTGERVDLNEEETIL---IIRRLHKVLRPFLLRR 249
DEXHc_CHD6 cd18058
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ...
 1-215 3.95e-17

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350816 [Multi-domain]  Cd Length: 222  Bit Score: 80.47  E-value: 3.95e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPEckpeiDKAVVVSPSSLVKNWYNEVGKWLggRIQPLAIDGG--SKDEIDQKLEGF 78
Cdd:cd18058    24 LADEMGLGKTIQSITFLSEIFLMGIR-----GPFLIIAPLSTITNWEREFRTWT--EMNAIVYHGSqiSRQMIQQYEMYY 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  79 MNQRGARVSS----PILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLE 154
Cdd:cd18058    97 RDEQGNPLSGifkfQVVITTFEMILADCPELKKINWSCVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEE 176

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1673538796 155 YFSLVHFVNSGILGTAHEFKKHFelpilkgrdaaaseADRQLgEERLRELTSIVNRCLIRR 215
Cdd:cd18058   177 LFSLLNFLEPSQFPSETTFLEEF--------------GDLKT-EEQVKKLQSILKPMMLRR 222
DEXDc_RapA cd18011
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ...
 2-165 9.55e-17

DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350769 [Multi-domain]  Cd Length: 207  Bit Score: 78.87  E-value: 9.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   2 ADEMGLGKTLQCITLMWTLLRQSpeckpEIDKAVVVSPSSLVKNWYNEVGKWLGgrIQPLAIDGGSKDEIdQKLEGFMNQ 81
Cdd:cd18011    23 ADEVGLGKTIEAGLIIKELLLRG-----DAKRVLILCPASLVEQWQDELQDKFG--LPFLILDRETAAQL-RRLIGNPFE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  82 RGarvssPILIISYETFR---LHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSL------NTSRRVLISGTPIQNDL 152
Cdd:cd18011    95 EF-----PIVIVSLDLLKrseERRGLLLSEEWDLVVVDEAHKLRNSGGGKETKRYKLgrllakRARHVLLLTATPHNGKE 169

                         170
                  ....*....|...
gi 1673538796 153 LEYFSLVHFVNSG 165
Cdd:cd18011   170 EDFRALLSLLDPG 182
DEXHc_SMARCA4 cd18062
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ...
 1-215 1.28e-16

DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350820 [Multi-domain]  Cd Length: 251  Bit Score: 79.70  E-value: 1.28e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKPeidkAVVVSPSSLVKNWYNEVGKWlggriQPLAIDGGSKDEIDQKLEGFMN 80
Cdd:cd18062    47 LADEMGLGKTIQTIALITYLMEHKRINGP----FLIIVPLSTLSNWVYEFDKW-----APSVVKVSYKGSPAARRAFVPQ 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  81 QRGARVSspILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTS-RRVLISGTPIQNDLLEYFSLV 159
Cdd:cd18062   118 LRSGKFN--VLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVApRRLLLTGTPLQNKLPELWALL 195

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1673538796 160 HFVNSGILGTAHEFKKHFELPI-LKGRDAAASEADRQLgeeRLRELTSIVNRCLIRR 215
Cdd:cd18062   196 NFLLPTIFKSCSTFEQWFNAPFaMTGEKVDLNEEETIL---IIRRLHKVLRPFLLRR 249
DEXHc_CHD4 cd18056
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ...
 1-162 1.50e-16

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350814 [Multi-domain]  Cd Length: 232  Bit Score: 78.95  E-value: 1.50e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKPeidkAVVVSPSSLVKNWYNEVGKW---------LGGRIQPLAIDGGSKDEI 71
Cdd:cd18056    24 LADEMGLGKTVQTAVFLYSLYKEGHSKGP----FLVSAPLSTIINWEREFEMWapdmyvvtyVGDKDSRAIIRENEFSFE 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  72 DQKLEGFMN----QRGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTP 147
Cdd:cd18056   100 DNAIRGGKKasrmKKEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTP 179

                         170
                  ....*....|....*
gi 1673538796 148 IQNDLLEYFSLVHFV 162
Cdd:cd18056   180 LQNNLEELFHLLNFL 194
DEXHc_SMARCA1 cd18065
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ...
 1-215 1.62e-16

DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350823 [Multi-domain]  Cd Length: 233  Bit Score: 78.91  E-value: 1.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPECKPEIdkavVVSPSSLVKNWYNEVGKWLGGRIQPLAIdgGSKDeidqKLEGFMN 80
Cdd:cd18065    39 LADEMGLGKTLQTIALLGYLKHYRNIPGPHM----VLVPKSTLHNWMNEFKRWVPSLRAVCLI--GDKD----ARAAFIR 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  81 QRGARVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVH 160
Cdd:cd18065   109 DVMMPGEWDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLN 188

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1673538796 161 FVNSGILGTAHEFKKHFelpilkgrdaaasEADRQLGEERLRE-LTSIVNRCLIRR 215
Cdd:cd18065   189 FLLPDVFNSADDFDSWF-------------DTKNCLGDQKLVErLHAVLKPFLLRR 231
DEXHc_CHD3_4_5 cd17994
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ...
 1-178 1.92e-16

DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350752 [Multi-domain]  Cd Length: 196  Bit Score: 77.86  E-value: 1.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSpECKPEIdkaVVVSPSSLVKNWYNEVGKWlggriQPlaidggskdeiDQKLEGFmn 80
Cdd:cd17994    24 LADEMGLGKTIQTIVFLYSLYKEG-HSKGPF---LVSAPLSTIINWEREFEMW-----AP-----------DFYVVTY-- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  81 qrgarVSSPILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVH 160
Cdd:cd17994    82 -----VGDHVLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQNNLEELFHLLN 156

                         170
                  ....*....|....*...
gi 1673538796 161 FVNSGILGTAHEFKKHFE 178
Cdd:cd17994   157 FLTPERFNNLQGFLEEFA 174
DEXHc_CHD9 cd18061
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ...
 1-215 1.38e-15

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350819 [Multi-domain]  Cd Length: 222  Bit Score: 76.20  E-value: 1.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPEckpeiDKAVVVSPSSLVKNWYNEVGKWLggRIQPLAIDGG--SKDEIDQKLEGF 78
Cdd:cd18061    24 LADEMGLGKTIQSITFLYEILLTGIR-----GPFLIIAPLSTIANWEREFRTWT--DLNVVVYHGSliSRQMIQQYEMYF 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  79 MNQRGARVSSPI----LIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLE 154
Cdd:cd18061    97 RDSQGRIIRGAYrfqaIITTFEMILGGCPELNAIDWRCVIIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEE 176

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1673538796 155 YFSLVHFVNSGILGTAHEFKKHFelpilkgrdaaaseADRQLgEERLRELTSIVNRCLIRR 215
Cdd:cd18061   177 LFSLLHFLEPLRFPSESTFMQEF--------------GDLKT-EEQVQKLQAILKPMMLRR 222
DEXHc_HLTF1_SMARC3 cd18071
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ...
 1-215 1.38e-15

DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350829 [Multi-domain]  Cd Length: 239  Bit Score: 76.35  E-value: 1.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTllrqspeckpeiDKAVVVSPSSLVKNWYNEVGKwlggRIQPLAID-----GGSKDEIDQKL 75
Cdd:cd18071    53 LADDMGLGKTLTTISLILA------------NFTLIVCPLSVLSNWETQFEE----HVKPGQLKvytyhGGERNRDPKLL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  76 EGFmnqrgarvssPILIISYETFRLHVGvlQKGSVGL-------VICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPI 148
Cdd:cd18071   117 SKY----------DIVLTTYNTLASDFG--AKGDSPLhtinwlrVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPI 184

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1673538796 149 QNDLLEYFSLVHFVNSGILGTAHEFKKHFELPILKGRDAAaseadrqlgeerLRELTSIVNRCLIRR 215
Cdd:cd18071   185 QNSPKDLGSLLSFLHLKPFSNPEYWRRLIQRPLTMGDPTG------------LKRLQVLMKQITLRR 239
DEXHc_CHD7 cd18059
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ...
 1-215 1.41e-15

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350817 [Multi-domain]  Cd Length: 222  Bit Score: 76.22  E-value: 1.41e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMWTLLRQSPEckpeiDKAVVVSPSSLVKNWYNEVGKWLGGRIQPLAIDGGSKDEIDQKLEGFMN 80
Cdd:cd18059    24 LADEMGLGKTIQSITFLYEIYLKGIH-----GPFLVIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKD 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  81 QRGARVSSP----ILIISYETFRLHVGVLQKGSVGLVICDEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYF 156
Cdd:cd18059    99 PQGRVIKGSykfhAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELF 178

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1673538796 157 SLVHFVNSGILGTAHEFKKHFelpilkgrdaaaseADRQLgEERLRELTSIVNRCLIRR 215
Cdd:cd18059   179 SLLHFLEPSRFPSETTFMQEF--------------GDLKT-EEQVQKLQAILKPMMLRR 222
DEXHc_TTF2 cd18072
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ...
 1-163 2.20e-14

DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350830 [Multi-domain]  Cd Length: 241  Bit Score: 72.90  E-value: 2.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLQCITLMW--------------TLLRQSPECKPEID----KAVVVSPSSLVKNWYNEVGKWL-GGRIQPL 61
Cdd:cd18072    25 LADDMGLGKTLTMIALILaqkntqnrkeeekeKALTEWESKKDSTLvpsaGTLVVCPASLVHQWKNEVESRVaSNKLRVC 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  62 AIDGGSKDEIDQKLEGFmnqrgarvssPILIISYETFRLHVGVLQKGSVGL---------VICDEGHRLKNSENQTYQAL 132
Cdd:cd18072   105 LYHGPNRERIGEVLRDY----------DIVITTYSLVAKEIPTYKEESRSSplfriawarIILDEAHNIKNPKVQASIAV 174

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1673538796 133 DSLNTSRRVLISGTPIQNDLLEYFSLVHFVN 163
Cdd:cd18072   175 CKLRAHARWALTGTPIQNNLLDMYSLLKFLR 205
DEXQc_bact_SNF2 cd18013
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ...
 4-165 1.92e-08

DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350771 [Multi-domain]  Cd Length: 218  Bit Score: 55.05  E-value: 1.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   4 EMGLGKTLQCITLMWTLLRQSPeckpeIDKAVVVSPSSLVKN-WYNEVGKWLGGRIQPLAIDGGSKdeidqklegfmNQR 82
Cdd:cd18013    23 DMGLGKTVTTLTALSDLQLDDF-----TRRVLVIAPLRVARStWPDEVEKWNHLRNLTVSVAVGTE-----------RQR 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  83 GARVSSP--ILIISYEtfRLHVGVLQKG---SVGLVICDEGHRLKNSENQTYQALDSLN--TSRRVLISGTPIQNDLLEY 155
Cdd:cd18013    87 SKAANTPadLYVINRE--NLKWLVNKSGdpwPFDMVVIDELSSFKSPRSKRFKALRKVRpvIKRLIGLTGTPSPNGLMDL 164

                         170
                  ....*....|
gi 1673538796 156 FSLVHFVNSG 165
Cdd:cd18013   165 WAQIALLDQG 174
DEXQc_SHPRH cd18070
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ...
 2-161 3.08e-07

DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350828 [Multi-domain]  Cd Length: 257  Bit Score: 51.96  E-value: 3.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   2 ADEMGLGKTLQCITLM----------------WTLLRQSPECKPEIDKAV-----VVSPSSLVKNWYNEVGKWLGGRIQP 60
Cdd:cd18070    20 ADEMGLGKTVEVLALIllhprpdndldaadddSDEMVCCPDCLVAETPVSskatlIVCPSAILAQWLDEINRHVPSSLKV 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  61 LAIDGGSKDEIDQKlegfmnQRGARVSSP-ILIISYETFR--LHV---------GVLQKGSVGL-----------VICDE 117
Cdd:cd18070   100 LTYQGVKKDGALAS------PAPEILAEYdIVVTTYDVLRteLHYaeanrsnrrRRRQKRYEAPpsplvlvewwrVCLDE 173

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1673538796 118 GHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVHF 161
Cdd:cd18070   174 AQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSF 217
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
6-210 4.51e-07

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 52.72  E-value: 4.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   6 GLGKTlqcITLMWTLLRQSpeckpEIDKAVVVSPS-SLVKNWYNEVGKWLGgriqpLAIDGGSKDEIDqklegfmnqrga 84
Cdd:COG1061   110 GTGKT---VLALALAAELL-----RGKRVLVLVPRrELLEQWAEELRRFLG-----DPLAGGGKKDSD------------ 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796  85 rvsSPILIISYETF--RLHVGVLQKgSVGLVICDEGHRLknSENQTYQALDSLNTSRRVLISGTPIQND----LLEYF-- 156
Cdd:COG1061   165 ---APITVATYQSLarRAHLDELGD-RFGLVIIDEAHHA--GAPSYRRILEAFPAAYRLGLTATPFRSDgreiLLFLFdg 238

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1673538796 157 -----SLVHFVNSGILGTAHEFKKHFELPILKGRDAAASEADRQL---GEER-LRELTSIVNR 210
Cdd:COG1061   239 ivyeySLKEAIEDGYLAPPEYYGIRVDLTDERAEYDALSERLREAlaaDAERkDKILRELLRE 301
ResIII pfam04851
Type III restriction enzyme, res subunit;
6-148 5.36e-06

Type III restriction enzyme, res subunit;


Pssm-ID: 398492 [Multi-domain]  Cd Length: 162  Bit Score: 46.90  E-value: 5.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   6 GLGKTLQCITLMWTLLRQSPeckpeIDKAVVVSPS-SLVKNWYNEVGKWLGG-RIQPLAIDGGSKDEIdqklegfmnqrg 83
Cdd:pfam04851  33 GSGKTLTAAKLIARLFKKGP-----IKKVLFLVPRkDLLEQALEEFKKFLPNyVEIGEIISGDKKDES------------ 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1673538796  84 aRVSSPILIISYETF--RLHVGVLQ--KGSVGLVICDEGHRLkNSENQTyQALDSLNTSRRVLISGTPI 148
Cdd:pfam04851  96 -VDDNKIVVTTIQSLykALELASLEllPDFFDVIIIDEAHRS-GASSYR-NILEYFKPAFLLGLTATPE 161
DpdE NF041062
protein DpdE;
2-163 1.59e-05

protein DpdE;


Pssm-ID: 468989 [Multi-domain]  Cd Length: 1048  Bit Score: 48.04  E-value: 1.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796    2 ADEMGLGKTLQ-CITLMWTLLRqspecKPEiDKAVVVSPSSLVKNWynevgkwlggriqplaidggsKDEIDQK--LEGF 78
Cdd:NF041062   176 ADEVGLGKTIEaGLVIRQHLLD-----NPD-ARVLVLVPDALVRQW---------------------RRELRDKffLDDF 228

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   79 MNQRgarvsspILIISYETFRlhvGVLQKGSV-GLVICDEGHRL-------KNSENQTYQALDSL--NTSRRVLISGTPI 148
Cdd:NF041062   229 PGAR-------VRVLSHEEPE---RWEPLLDApDLLVVDEAHQLarlawsgDPPERARYRELAALahAAPRLLLLSATPV 298

                          170
                   ....*....|....*
gi 1673538796  149 QNDLLEYFSLVHFVN 163
Cdd:NF041062   299 LGNEETFLALLHLLD 313
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 6-150 2.32e-05

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 44.93  E-value: 2.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   6 GLGKTLqciTLMWTLLRQSPECKPEIdKAVVVSPS-SLVKNWYNEV---GKWLGGRIQpLAIDGGSKDEIDQKLEGfmnq 81
Cdd:pfam00270  24 GSGKTL---AFLLPALEALDKLDNGP-QALVLAPTrELAEQIYEELkklGKGLGLKVA-SLLGGDSRKEQLEKLKG---- 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1673538796  82 rgarvsSPILIISYETFRLHVGVLQK-GSVGLVICDEGHRL--KNSENQTYQALDSLNTSRR-VLISGTPIQN 150
Cdd:pfam00270  95 ------PDILVGTPGRLLDLLQERKLlKNLKLLVLDEAHRLldMGFGPDLEEILRRLPKKRQiLLLSATLPRN 161
HDA2-3 pfam11496
Class II histone deacetylase complex subunits 2 and 3; This family of class II histone ...
 315-448 7.99e-05

Class II histone deacetylase complex subunits 2 and 3; This family of class II histone deacetylase complex subunits HDA2 and HDA3 is found in fungi, The member from S. pombe is referred to as Ccq1 in Swiss:Q10432. These proteins associate with HDA1 to generate the activity of the HDA1 histone deacetylase complex. HDA1 interacts with itself and with the HDA2-HDA3 subcomplex to form a probable tetramer and these interactions are necessary for catalytic activity. The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDA2 and HDA3 have a conserved coiled-coil domain towards their C-terminus.


Pssm-ID: 402894  Cd Length: 281  Bit Score: 44.63  E-value: 7.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796 315 SGKMLVLDYILAVTRSRSSDK---VVLVSNYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKV-VERFNSPSSPDFVFM 390
Cdd:pfam11496  89 SGKFLVLNDLVNLLIERDRKEpinVAIVARSGKTLDLVEALLLGKGLSYKRYSGEMLYGENKKVsDSGNKKIHSTTCHLL 168

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1673538796 391 -----LSSKAGGcgLNLIGANRLVMFDPDWNPANDEQAMARVWRDGQKKTCYIYRLLSAGTIE 448
Cdd:pfam11496 169 sstgqLTNDDSL--LENYKFDLIIAFDSSVDTSSPSVEHLRTQNRRKGNLAPIIRLVVINSIE 229
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 1-146 4.62e-03

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 37.77  E-value: 4.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1673538796   1 MADEMGLGKTLqcITLMWTLLRqspeCKPEIDKAVVVSP-SSLVKNWYNEVGKWLGGRIQPLAIDGGSKDEIDQKLegfm 79
Cdd:cd00046     6 ITAPTGSGKTL--AALLAALLL----LLKKGKKVLVLVPtKALALQTAERLRELFGPGIRVAVLVGGSSAEEREKN---- 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1673538796  80 nqrgARVSSPILIISYETFR---LHVGVLQKGSVGLVICDEGHRL------KNSENQTYQALDSLNtSRRVLISGT 146
Cdd:cd00046    76 ----KLGDADIIIATPDMLLnllLREDRLFLKDLKLIIVDEAHALlidsrgALILDLAVRKAGLKN-AQVILLSAT 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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