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Conserved domains on  [gi|1672620298|ref|WP_138266880|]
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ROK family protein [Bifidobacterium pseudocatenulatum]

Protein Classification

ROK family protein( domain architecture ID 11449187)

ROK (Repressor, ORF, Kinase) family protein functions as a sugar kinase or may act as a transcriptional regulator involved in carbohydrate-dependent transcriptional control

CATH:  3.30.420.40
Gene Ontology:  GO:0005524
PubMed:  20512568|17979299
SCOP:  3000092|4000330

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_ATPase-like super family cl49607
ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA ...
 100-399 1.50e-59

ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA superfamily, also known as actin-like ATPase domain superfamily, includes acetate and sugar kinases, heat-shock cognate 70 (Hsp70) and actin family proteins. They either function as conformational hydrolases (e.g. Hsp70, actin) that perform simple ATP hydrolysis, or as metabolite kinases (e.g. glycerol kinase) that catalyze the transfer of a phosphoryl group from ATP to their cognate substrates. Both activities depend on the presence of specific metal cations. ASKHA superfamily members share a common core fold that includes an actin-like ATPase domain consisting of two subdomains (denoted I _ II) with highly similar ribonuclease (RNase) H-like folds. The fold of each subdomain is characterized by a central five strand beta-sheet and flanking alpha-helices. The two subdomains form an active site cleft in which ATP binds at the bottom. Another common feature of ASKHA superfamily members is the coupling of phosphoryl-group transfer to conformational rearrangement, leading to domain closure. Substrate binding triggers protein motion.


The actual alignment was detected with superfamily member cd24073:

Pssm-ID: 483947 [Multi-domain]  Cd Length: 304  Bit Score: 195.46  E-value: 1.50e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 100 FVGMKINATHISAVAVNAIGQIItGCHDLKIEDASPQTVVALIKQLTTDCSDEAEMAGwPKPCAVGISLGGHI--VDGTV 177
Cdd:cd24073     3 VVGVKLTEDRITAVLTDLRGNVL-ASHTLPLDSGDPEAVAEAIAEAVAELLAQAGLSP-DRLLGIGVGLPGLVdaETGIC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 178 VtFAPFMHWSQpVELSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVSCPDKSYG 257
Cdd:cd24073    81 R-WSPLLGWRD-VPLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRGAHGGAG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 258 LVGHILVDPDGPRCVSGHRGCAQCL-SDNSIAAEYSQIIG--HPASFDDFARDARANKPQATNLVNRTCFRLGTLVATIA 334
Cdd:cd24073   159 EIGHTTVDPDGPPCRCGKRGCLEAYaSDPAILRQAREAGLrgEPLTIEDLLAAARAGDPAARAILRRAGRALGLALANLV 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1672620298 335 NLAMPDKIMIAGESSFIAKFGIDDLRNGINMYRHSQAA-PVDFEIpdHDWA--LWAKAAASQAIRQYV 399
Cdd:cd24073   239 NLLDPELIIISGEGVRAGDLLFEPMREALRAHVFPGLAsDLELVI--HPWGdeAWARGAAALALQEFF 304
 
Name Accession Description Interval E-value
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 100-399 1.50e-59

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 195.46  E-value: 1.50e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 100 FVGMKINATHISAVAVNAIGQIItGCHDLKIEDASPQTVVALIKQLTTDCSDEAEMAGwPKPCAVGISLGGHI--VDGTV 177
Cdd:cd24073     3 VVGVKLTEDRITAVLTDLRGNVL-ASHTLPLDSGDPEAVAEAIAEAVAELLAQAGLSP-DRLLGIGVGLPGLVdaETGIC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 178 VtFAPFMHWSQpVELSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVSCPDKSYG 257
Cdd:cd24073    81 R-WSPLLGWRD-VPLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRGAHGGAG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 258 LVGHILVDPDGPRCVSGHRGCAQCL-SDNSIAAEYSQIIG--HPASFDDFARDARANKPQATNLVNRTCFRLGTLVATIA 334
Cdd:cd24073   159 EIGHTTVDPDGPPCRCGKRGCLEAYaSDPAILRQAREAGLrgEPLTIEDLLAAARAGDPAARAILRRAGRALGLALANLV 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1672620298 335 NLAMPDKIMIAGESSFIAKFGIDDLRNGINMYRHSQAA-PVDFEIpdHDWA--LWAKAAASQAIRQYV 399
Cdd:cd24073   239 NLLDPELIIISGEGVRAGDLLFEPMREALRAHVFPGLAsDLELVI--HPWGdeAWARGAAALALQEFF 304
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 95-396 4.34e-41

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 147.35  E-value: 4.34e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298  95 ANARSFVGMKINATHISAVAVNAIGQIItgcHDLKIE---DASPQTVVALIKQLTTDCSDEAEMAgWPKPCAVGISLGGH 171
Cdd:COG1940     2 PDAGYVIGIDIGGTKIKAALVDLDGEVL---ARERIPtpaGAGPEAVLEAIAELIEELLAEAGIS-RGRILGIGIGVPGP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 172 I-VDGTVVTFAPFMHWSQPVELSVMVREATGLPTGIYNDIDSlvvdACL----FGPGVGLDSFAVLTFGAGVGYSLTFNG 246
Cdd:COG1940    78 VdPETGVVLNAPNLPGWRGVPLAELLEERLGLPVFVENDANA----AALaeawFGAGRGADNVVYLTLGTGIGGGIVING 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 247 ELVSCPDKSYGLVGHILVDPDGPRCVSGHRGCA-QCLSDNSIAAEYSQIIGHPA-SFDDFARDARANKPQATNLVNRTCF 324
Cdd:COG1940   154 KLLRGANGNAGEIGHMPVDPDGPLCGCGNRGCLeTYASGPALLRRARELGGAEKlTAEELFAAARAGDPLALEVLDEAAR 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1672620298 325 RLGTLVATIANLAMPDKIMIAGESSFIAKFGIDDLRNGINMYRHSQAA-PVDFEIPDHDWALWAKAAASQAIR 396
Cdd:COG1940   234 YLGIGLANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAReDPRIVPASLGDDAGLLGAAALALE 306
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 101-347 3.11e-24

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 101.26  E-value: 3.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 101 VGMKINATHISAVAVNAIGQIItgcHDLKIEDASPQTVVALIKQLTTDCSDEAEMAGwpKPCAVGISLGGHIVDG-TVVT 179
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEIL---ARERVPTPTTTTEETLVDAIAFFVDSAQRKFG--ELIAVGIGSPGLISPKyGYIT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 180 FAPFMHWSQpVELSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVSCPDKSYGLV 259
Cdd:pfam00480  76 NTPNIGWDN-FDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEI 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 260 GHILVDPDGPRCVSGHRGCAQCLSDNSIAAEYSQIIGHPASFDDFARDARANKPQATNLVNRTCFRLGTLVATIANLAMP 339
Cdd:pfam00480 155 GHIQLDPNGPKCGCGNHGCLETIASGRALEKRYQQKGEDLEGKDIIVLAEQGDEVAEEAVERLARYLAKAIANLINLFDP 234


                  ....*...
gi 1672620298 340 DKIMIAGE 347
Cdd:pfam00480 235 QAIVLGGG 242
ROK_glcA_fam TIGR00744
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ...
 101-374 5.85e-14

ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]


Pssm-ID: 273246 [Multi-domain]  Cd Length: 318  Bit Score: 72.24  E-value: 5.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 101 VGMKINATHISAVAVNAIGQIItgcHDLKIE-DASPQTVVALIKQLTTDCSDEAEMAGwPKPCAVGISLGGHI-VDGTVV 178
Cdd:TIGR00744   1 IGVDIGGTTIKLGVVDEEGNIL---SKWKVPtDTTPETIVDAIASAVDSFIQHIAKVG-HEIVAIGIGAPGPVnRQRGTV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 179 TFAPFMHWSQPVeLSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVSCPDKSYGL 258
Cdd:TIGR00744  77 YFAVNLDWKQEP-LKEKVEARVGLPVVVENDANAAALGEYKKGAGKGARDVICITLGTGLGGGIIINGEIRHGHNGVGAE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 259 VGHILVDPDGP-RCVSGHRGCAQCLSDNSIAAEYSQ---------------IIGHPASFDDFARDARANKPQATNLVNRT 322
Cdd:TIGR00744 156 IGHIRMVPDGRlLCNCGKQGCIETYASATGLVRYAKranakperaevllalGDGDGISAKHVFVAARQGDPVAVDSYREV 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1672620298 323 CFRLGTLVATIANLAMPDKIMIAGESSFIAKFGIDDLRNGINMYRHSQAAPV 374
Cdd:TIGR00744 236 ARWAGAGLADLASLFNPSAIVLGGGLSDAGDLLLDPIRKSYKRWLFGGARQV 287
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 105-336 2.87e-11

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 63.78  E-value: 2.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 105 INATHISAVAVNAIGQIITgchdlKIEDASPQ--TVVALIKQLTTDCSDEAEMAGwpkpcAVGISLGGHIVDGtVVT--- 179
Cdd:PRK05082    8 IGGTKIAAALVGEDGQIRQ-----RRQIPTPAsqTPEALRQALSALVSPLQAQAD-----RVAVASTGIINDG-ILTaln 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 180 ------FAPFmhwsqPVELSVmvREATGLPTGIYNDIDSLVVDACLFGPGVGLDsFAVLTFGAGVGYSLTFNGELVSCPD 253
Cdd:PRK05082   77 phnlggLLHF-----PLVQTL--EQLTDLPTIALNDAQAAAWAEYQALPDDIRN-MVFITVSTGVGGGIVLNGKLLTGPG 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 254 KSYGLVGHILVDPDGPRCVSGHRGCAQCL-SDNSIAAEYSQIIGHPASFDDFARdARANKPQATNLVNRTcfrlgtlVAT 332
Cdd:PRK05082  149 GLAGHIGHTLADPHGPVCGCGRRGCVEAIaSGRAIAAAAQGWLAGCDAKTIFER-AGQGDEQAQALINRS-------AQA 220


                  ....
gi 1672620298 333 IANL 336
Cdd:PRK05082  221 IARL 224
 
Name Accession Description Interval E-value
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 100-399 1.50e-59

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 195.46  E-value: 1.50e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 100 FVGMKINATHISAVAVNAIGQIItGCHDLKIEDASPQTVVALIKQLTTDCSDEAEMAGwPKPCAVGISLGGHI--VDGTV 177
Cdd:cd24073     3 VVGVKLTEDRITAVLTDLRGNVL-ASHTLPLDSGDPEAVAEAIAEAVAELLAQAGLSP-DRLLGIGVGLPGLVdaETGIC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 178 VtFAPFMHWSQpVELSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVSCPDKSYG 257
Cdd:cd24073    81 R-WSPLLGWRD-VPLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRGAHGGAG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 258 LVGHILVDPDGPRCVSGHRGCAQCL-SDNSIAAEYSQIIG--HPASFDDFARDARANKPQATNLVNRTCFRLGTLVATIA 334
Cdd:cd24073   159 EIGHTTVDPDGPPCRCGKRGCLEAYaSDPAILRQAREAGLrgEPLTIEDLLAAARAGDPAARAILRRAGRALGLALANLV 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1672620298 335 NLAMPDKIMIAGESSFIAKFGIDDLRNGINMYRHSQAA-PVDFEIpdHDWA--LWAKAAASQAIRQYV 399
Cdd:cd24073   239 NLLDPELIIISGEGVRAGDLLFEPMREALRAHVFPGLAsDLELVI--HPWGdeAWARGAAALALQEFF 304
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 95-396 4.34e-41

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 147.35  E-value: 4.34e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298  95 ANARSFVGMKINATHISAVAVNAIGQIItgcHDLKIE---DASPQTVVALIKQLTTDCSDEAEMAgWPKPCAVGISLGGH 171
Cdd:COG1940     2 PDAGYVIGIDIGGTKIKAALVDLDGEVL---ARERIPtpaGAGPEAVLEAIAELIEELLAEAGIS-RGRILGIGIGVPGP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 172 I-VDGTVVTFAPFMHWSQPVELSVMVREATGLPTGIYNDIDSlvvdACL----FGPGVGLDSFAVLTFGAGVGYSLTFNG 246
Cdd:COG1940    78 VdPETGVVLNAPNLPGWRGVPLAELLEERLGLPVFVENDANA----AALaeawFGAGRGADNVVYLTLGTGIGGGIVING 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 247 ELVSCPDKSYGLVGHILVDPDGPRCVSGHRGCA-QCLSDNSIAAEYSQIIGHPA-SFDDFARDARANKPQATNLVNRTCF 324
Cdd:COG1940   154 KLLRGANGNAGEIGHMPVDPDGPLCGCGNRGCLeTYASGPALLRRARELGGAEKlTAEELFAAARAGDPLALEVLDEAAR 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1672620298 325 RLGTLVATIANLAMPDKIMIAGESSFIAKFGIDDLRNGINMYRHSQAA-PVDFEIPDHDWALWAKAAASQAIR 396
Cdd:COG1940   234 YLGIGLANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAReDPRIVPASLGDDAGLLGAAALALE 306
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 100-373 2.71e-29

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 115.36  E-value: 2.71e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 100 FVGMKINATHISAVAVNAIGQIITGCHDLKIEDASPQTVVALIKQLTTDCSDEAEMAGWPkPCAVGISLGGhIVD---GT 176
Cdd:cd24076     3 VIGVELGVDYITVVVTDLAGEVLWRREVPLPASDDPDEVLAQLAALIREALAAAPDSPLG-ILGIGVGVPG-LVDsedGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 177 VVtFAPFMHWSQpVELSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVSCPDKSY 256
Cdd:cd24076    81 VL-LAPNLGWRD-VPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGASGFA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 257 GLVGHILVDPDGPRCVSGHRGCAQCL-SDNSIAAEYSQ--IIGHPASFDDFARDARANKPQATNLVNRTCFRLGTLVATI 333
Cdd:cd24076   159 GEIGHMTVDPDGPPCSCGNRGCWETYaSERALLRAAGRlgAGGEPLSLAELVEAARAGDPAALAALEEVGEYLGIGLANL 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1672620298 334 ANLAMPDKIMIAGESSFIAKFGIDDLRNGINmyRHSQAAP 373
Cdd:cd24076   239 VNTFNPELVVLGGALAPLGPWLLPPLRAEVA--RRALPAP 276
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 100-347 7.71e-25

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 103.52  E-value: 7.71e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 100 FVGMKINATHISAVAVNAIGQIItgcHDLKIE---DASPQTVVALIKQLTTDCSDEAEMAGwpKPCAVGISLGGhIVDGT 176
Cdd:cd24071     3 IIGVKIEEGYLVLALTDLKGKIL---EKTRIPfdhETDPEKVIELIAENIKKLIKNKHVEK--KLLGIGIAVSG-LVDSK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 177 --VVTFAPFMHWSQpVELSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVSCPDK 254
Cdd:cd24071    77 kgIVIRSTILGWEN-VELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICVTVGAGIGSSLVIDGKLYTGNFG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 255 SYGLVGHILVDPDGPRCVSGHRGCAQCL-SDNSIAAEYSQII----------GHPASFDDFARDARANKPQATNLVNRTC 323
Cdd:cd24071   156 GAGEIGHMTIQPDGRKCYCGQKGCLEAYaSFEALVNEIKELTesyplsllkeLEDFEIEKVREAAEEGDSVATELFKKAG 235

                         250       260
                  ....*....|....*....|....
gi 1672620298 324 FRLGTLVATIANLAMPDKIMIAGE 347
Cdd:cd24071   236 EYLGIGIKNLINIFNPEAIIIGGE 259
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 101-347 3.11e-24

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 101.26  E-value: 3.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 101 VGMKINATHISAVAVNAIGQIItgcHDLKIEDASPQTVVALIKQLTTDCSDEAEMAGwpKPCAVGISLGGHIVDG-TVVT 179
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEIL---ARERVPTPTTTTEETLVDAIAFFVDSAQRKFG--ELIAVGIGSPGLISPKyGYIT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 180 FAPFMHWSQpVELSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVSCPDKSYGLV 259
Cdd:pfam00480  76 NTPNIGWDN-FDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEI 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 260 GHILVDPDGPRCVSGHRGCAQCLSDNSIAAEYSQIIGHPASFDDFARDARANKPQATNLVNRTCFRLGTLVATIANLAMP 339
Cdd:pfam00480 155 GHIQLDPNGPKCGCGNHGCLETIASGRALEKRYQQKGEDLEGKDIIVLAEQGDEVAEEAVERLARYLAKAIANLINLFDP 234


                  ....*...
gi 1672620298 340 DKIMIAGE 347
Cdd:pfam00480 235 QAIVLGGG 242
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 100-346 9.32e-23

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 97.24  E-value: 9.32e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 100 FVGMKINATHISAVAVNAIGQII------TGCHDLKieDASPQTVVALIKQLTTDcsdeaemagwPKPCAVGISLGGHI- 172
Cdd:cd24068     2 ILGIDIGGTKIKYGLVDADGEILekdsvpTPASKGG--DAILERLLEIIAELKEK----------YDIEGIGISSAGQVd 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 173 -VDGTVVTFAP-FMHWSQpVELSVMVREATGLPTGIYNDIDSlvvdACL----FGPGVGLDSFAVLTFGAGVGYSLTFNG 246
Cdd:cd24068    70 pKTGEVIYATDnLPGWTG-TNLKEELEERFGLPVAVENDVNC----AALaekwLGAAKGLDDFLCLTLGTGIGGAIILDG 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 247 ELVSCPDKSYGLVGHILVDPDGPRCVSGHRGCAQCL-SDNSIAAEYSQIIGHPA-SFDDFARDARANKPQATNLVNRTCF 324
Cdd:cd24068   145 RLYRGANGSAGELGHMVVDPGGRPCCCGGKGCLEQYaSGTALVRRVAEALGEPGiDGREIFDLADAGDPLAKEVVEEFAE 224

                         250       260
                  ....*....|....*....|..
gi 1672620298 325 RLGTLVATIANLAMPDKIMIAG 346
Cdd:cd24068   225 DLATGLANLVHIFDPEVIVIGG 246
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 101-399 1.64e-22

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 96.50  E-value: 1.64e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 101 VGMKINATHISAVAVNAIGQIITGCHDLKIEDASPQTVVALIKQLTTDCSDEAEMAgwPKPCAVGISLGGHI--VDGTVV 178
Cdd:cd24059     4 IGVEIGRDLLSAVLCDLSGNILAREKYPLDEKENPEEVLEKLYELIDRLLEKENIK--SKILGIGIGAPGPLdvEKGIIL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 179 TFAPFMHWSQpVELSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVSCPDKSYGL 258
Cdd:cd24059    82 NPPNFPGWEN-IPLVELLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGVDGYAGE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 259 VGHILVDPDGPRCVSGHRGCAQ--CLSDNSIAAEYSQIIGHPASFDDFARDARANKPQATNLVNRTCFRLGTLVATIANL 336
Cdd:cd24059   161 IGHTSIDINGPRCSCGNRGCLElyASIPAIEKKARSALGSGRSFQLDIVEALQKGDPIADEVIEEAAKYLGIGLVNLINL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1672620298 337 AMPDKIMIAGESSFIAKFGIDDLRNGINMYRHSQAA-PVDFEIPDHDWALWAKAAASQAIRQYV 399
Cdd:cd24059   241 LNPEAIIIGGELIYLGERYLEPIEKEVNSRLFGRNArEVRILKSSLGEDAPLLGAAALVLNKYF 304
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 101-360 1.13e-19

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 88.71  E-value: 1.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 101 VGMKINATHISAVAVNAIGQIITG-CHDLKIEDASPQtVVALIKQLTTDCSDEAEMAGwpkpcaVGISLGGHI-VDGTVV 178
Cdd:cd24064     2 IGIDLGGTDTKIGIVDENGDILKKkTIDTKVENGKED-VINRIAETVNELIEEMELLG------IGIGSPGSIdRENGIV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 179 TFAP-FMHWSQpVELSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVSCPDKSYG 257
Cdd:cd24064    75 RFSPnFPDWRN-FPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNHIIGLTLGTGVGSGVICHGQLLTGYDGIAA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 258 LVGHILVDPDGPRCVSGHRGCAQCLSDNSIAAEY---------SQIIGHPASFD--DFARDARANKPQATNLVNRTCFRL 326
Cdd:cd24064   154 ELGHVIVEPNGPICGCGNRGCVEAFASATAIIRYaresrkrypDSLAGESEKINakHVFDAARKNDPLATMVFRRVVDAL 233

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1672620298 327 GTLVATIANLAMPDKIMIAGESSFIAKFGIDDLR 360
Cdd:cd24064   234 AIAIGGFVHIFNPEIIIIGGGISRAGSFLLDPIR 267
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 101-347 1.25e-18

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 85.88  E-value: 1.25e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 101 VGMKINATHISAVAVNAIGQIITGcHDLKIEDASPQTV----VALIKQLTTDCSDEAEmagwpKPCAVGISLGGHIVDGT 176
Cdd:cd24075     4 LAVRLGRHDLTLGLYDLSGELLAE-HTVPLTALNQEALlsqlIEEIAQFLKSHRRKTQ-----RLIAISITLPGLINPKT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 177 -VVTFAPFMHWsQPVELSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVSCPDKS 255
Cdd:cd24075    78 gVVHYMPHIQV-KSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGN 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 256 YGLVGHILVDPDGPRCVSGHRGCAQCL-SDNSIAAEYSQII--GHPASF-------DDFARDARANKPQATNLVNRTCFR 325
Cdd:cd24075   157 AGEIGHIQIEPLGERCHCGNFGCLETVaSNAAIEQRVKKLLkqGYASQLtlqdctiKDICQAALNGDQLAQDVIKRAGRY 236

                         250       260
                  ....*....|....*....|..
gi 1672620298 326 LGTLVATIANLAMPDKIMIAGE 347
Cdd:cd24075   237 LGKVIAILINLLNPQKIIIAGE 258
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 101-372 5.79e-18

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 82.51  E-value: 5.79e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 101 VGMKINATHISAVAVNAIGQIItGCHDLKIE-DASPQTVVALIKQLTTDCSDEAEMagWPKPCAVGISLGGhIVDGT--V 177
Cdd:cd23763     1 IGIDIGGTKIRAALVDLDGEIL-ARERVPTPaEEGPEAVLDRIAELIEELLAEAGV--RERILGIGIGVPG-PVDPEtgI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 178 VTFAPFMHWSQPVELSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELvscpdksyg 257
Cdd:cd23763    77 VLFAPNLPWWKNVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRGVRNFVYITLGTGIGGGIIIDGKL--------- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 258 lvghilvdpdgprcVSGHRGCaqclsdnsiAAEysqiIGHpasfddfardarankpqaTNLVNRTCFRLGTLVATIANLA 337
Cdd:cd23763   148 --------------YRGANGA---------AGE----IGH------------------ITVLEEAARYLGIGLANLINLL 182

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1672620298 338 MPDKIMIAGESSFIAKFGIDDLRNGINMYRHSQAA 372
Cdd:cd23763   183 NPELIVLGGGVAEAGDLLLEPIREAVRRRALPPLR 217
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 101-346 6.34e-18

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 83.62  E-value: 6.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 101 VGMKINATHISAVAVNAIGQIITGCHDLKIEDASPQtvvALIKQLTtDCSDEAEMAgWPKPCA-VGISLGGhIVD---GT 176
Cdd:cd24072     4 LGIVVSPNSLRAQVGNACGELLGEFEYRVITLETPE---ALIDEII-DCIDRLLKL-WKDRVKgIALAIQG-LVDshkGV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 177 VVtFAPFMHWsQPVELSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVSCPDKSY 256
Cdd:cd24072    78 SL-WSPGAPW-RNIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVINLDYGIGSAIVIDNKLYIGASSGS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 257 GLVGHILVDPDGPRCVSGHRGCAQCL-SDNSIAAEYSQIIGHPA--------SFDDFARDARANKPQATNLVNRTCFRLG 327
Cdd:cd24072   156 GEIGHTKVNPDGARCDCGRRGCLETVaSNSALKRNARVTLKLGPvsadpeklTMEQLIEALEEGEPIATQIFDRAANAIG 235

                         250
                  ....*....|....*....
gi 1672620298 328 TLVATIANLAMPDKIMIAG 346
Cdd:cd24072   236 RSLANILNLLNPEQVLLYG 254
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 164-346 8.01e-17

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 80.02  E-value: 8.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 164 VGISLGGHIVDGTVVTFAPFMHWSQPV-ELSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSL 242
Cdd:cd24069    55 VAVASTGIIRDGVLTALNPKNLGGLSGfPLADALQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGNLVFITVSTGVGGGL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 243 TFNGELVSCPDKSYGLVGHILVDPDGPRCVSGHRGCAQCL-SDNSIAAEYSQIIGHPASFDDFARDARANKPQATNLVNR 321
Cdd:cd24069   135 VLNGQLLTGPNGLAGHIGHTLADPPGPVCGCGRRGCVEAIaSGTAIAAAASEILGEPVDAKDVFERARSGDEEAARLIDR 214

                         170       180
                  ....*....|....*....|....*
gi 1672620298 322 TCFRLGTLVATIANLAMPDKIMIAG 346
Cdd:cd24069   215 AARALADLIADLKATLDLDCVVIGG 239
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 101-360 9.80e-16

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 77.39  E-value: 9.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 101 VGMKINATHISAVAVNAIGQIITgchdlKIEDASPQTVVALIKQLttdCSDEAEMAGWPKPCAVGISLGGHI-VDGTVVT 179
Cdd:cd24061     2 IGVDIGGTKIAAGVVDEEGEILA-----TERVPTPPTADGIVDAI---VEAVEELREGHDVSAVGVAAAGFVdADRATVL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 180 FAPFMHWSQpVELSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVSCPDKSYGLV 259
Cdd:cd24061    74 FAPNIAWRN-EPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDMVMITVGTGLGGGIVIGGKLLRGAFGIAGEF 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 260 GHILVDPDGPRCVSGHRGC--------------AQCLSDNSIAAE--YSQIIGHPASFDDFARDARANKPQATNLVNRTC 323
Cdd:cd24061   153 GHIRVVPDGLLCGCGSRGCweqyasgralvryaKEAANATPEGAAvlLADGSVDGITGKHISEAARAGDPVALDALRELA 232

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1672620298 324 FRLGTLVATIANLAMPDKIMIAGESSFIAKFGIDDLR 360
Cdd:cd24061   233 RWLGAGLASLAALLDPELFVIGGGVSDAGDLLLDPIR 269
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 99-360 6.24e-15

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 74.67  E-value: 6.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298  99 SFVGMKINATHIsAVAVNAIGQIITgchdlKIEDASPQT----VVALIKQLTtdcsdEAEMAGWPKPCAVGISLGG--HI 172
Cdd:cd24065     1 STIGLDLGGTKI-AAGVVDGGRILS-----RLVVPTPREggeaVLDALARAV-----EALQAEAPGVEAVGLGVPGplDF 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 173 VDGTVvTFAPFMHWSQPVELSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVSCP 252
Cdd:cd24065    70 RRGRV-RFAPNIPGLTDFPIRRGLAERLGLPVVLENDANAAALAEHHYGAARGTESSVYVTISTGIGGGLVLGGRVLRGR 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 253 DKSYGLVGHILVDPDGPRCVSGHRGCAQCL-SDNSIAAEYSQIIGHPASFDDFARDARANKPQATNLVNRTCFRLGTLVA 331
Cdd:cd24065   149 HGQAGEIGHTTVLPGGPMCGCGLVGCLEALaSGRALARDASFAYGRPMSTAELFELAQQGEPKALRIVEQAAAHLGIGLA 228

                         250       260
                  ....*....|....*....|....*....
gi 1672620298 332 TIANLAMPDKIMIAGESSFIAKFGIDDLR 360
Cdd:cd24065   229 NLQKALDPEVFVLGGGVAQVGDYYLLPVQ 257
ASKHA_ATPase_ROK_SaXylR-like cd24077
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ...
 100-366 5.26e-14

ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466927 [Multi-domain]  Cd Length: 295  Bit Score: 71.80  E-value: 5.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 100 FVGMKINATHISAVAVNAIGQIITGcHDLKIEDASPQTVVALIKQLTTDCSDEAEMAGWPkpcAVGISLGGH-IVDGTVV 178
Cdd:cd24077     3 SIGIDLGYNYISLMLTYLDGEIISS-KQIKLLDISFENILEILKSIIQELISQAPKTPYG---LVGIGIGIHgIVDENEI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 179 TFAPFMHWSQpVELSVMVREATGLPTGIYN--------------DIDSLVVdaclfgpgvgldsfavLTFGAGVGYSLTF 244
Cdd:cd24077    79 IFTPYYDLED-IDLKEKLEEKFNVPVYLENeanlsalaertfseDYDNLIS----------------ISIHSGIGAGIII 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 245 NGELVSCPDKSYGLVGHILVDPDGPRCVSGHRGC-AQCLSDNSIAAEYSQIIG-HPASFDDFARDARANKPQATNLVNRT 322
Cdd:cd24077   142 NNQLYRGYNGFAGEIGHMIIVPNGKPCPCGNKGClEQYASEKALLKELSEKKGlETLTFDDLIQLYNEGDPEALELIDQF 221

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1672620298 323 CFRLGTLVATIANLAMPDKIMIagESSFIAKFG--IDDLRNGINMY 366
Cdd:cd24077   222 IKYLAIGINNIINTFNPEIIII--NSSLINEIPelLEKIKEQLSSS 265
ROK_glcA_fam TIGR00744
ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily ...
 101-374 5.85e-14

ROK family protein (putative glucokinase); This model models one branch of the ROK superfamily of proteins. The three members of the seed alignment for this model all have experimental evidence for activity as glucokinase, but the set of related proteins is crowded with paralogs of different or unknown function. Proteins scoring above the trusted_cutoff will show strong similarity to at least one known glucokinase and may be designated as putative glucokinases. However, definitive identification of glucokinases should be done only with extreme caution. [Unknown function, General]


Pssm-ID: 273246 [Multi-domain]  Cd Length: 318  Bit Score: 72.24  E-value: 5.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 101 VGMKINATHISAVAVNAIGQIItgcHDLKIE-DASPQTVVALIKQLTTDCSDEAEMAGwPKPCAVGISLGGHI-VDGTVV 178
Cdd:TIGR00744   1 IGVDIGGTTIKLGVVDEEGNIL---SKWKVPtDTTPETIVDAIASAVDSFIQHIAKVG-HEIVAIGIGAPGPVnRQRGTV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 179 TFAPFMHWSQPVeLSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVSCPDKSYGL 258
Cdd:TIGR00744  77 YFAVNLDWKQEP-LKEKVEARVGLPVVVENDANAAALGEYKKGAGKGARDVICITLGTGLGGGIIINGEIRHGHNGVGAE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 259 VGHILVDPDGP-RCVSGHRGCAQCLSDNSIAAEYSQ---------------IIGHPASFDDFARDARANKPQATNLVNRT 322
Cdd:TIGR00744 156 IGHIRMVPDGRlLCNCGKQGCIETYASATGLVRYAKranakperaevllalGDGDGISAKHVFVAARQGDPVAVDSYREV 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1672620298 323 CFRLGTLVATIANLAMPDKIMIAGESSFIAKFGIDDLRNGINMYRHSQAAPV 374
Cdd:TIGR00744 236 ARWAGAGLADLASLFNPSAIVLGGGLSDAGDLLLDPIRKSYKRWLFGGARQV 287
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 108-346 6.34e-13

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 68.98  E-value: 6.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 108 THISAVAVNAIGQIItgchdLKIEDASPQTV---VALIKQLTTDCSDEAEMAGwpkpC---AVGISLGGHI--VDGTVV- 178
Cdd:cd24060    10 TNLRVAIVSMKGEIV-----KKYTQPNPKTYeerIDLILQMCVEAASEAVKLN----CrilGVGISTGGRVnpREGIVLh 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 179 TFAPFMHWSQpVELSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVSCPDKSYGL 258
Cdd:cd24060    81 STKLIQEWSS-VDLRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITGTGIGGGIILNHELIHGSSFCAAE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 259 VGHILVDPDGPRCVSGHRGC-------------AQCLSDNSIAAEYSQII--GHPASFDDFARDARANKPQATNLVNRTC 323
Cdd:cd24060   160 LGHIVVSLDGPDCMCGSHGCveayasgmalqreAKKLHDEDLLLVEGMSVtnDEEVTAKHLIQAAKLGNAKAQKILRTAG 239

                         250       260
                  ....*....|....*....|...
gi 1672620298 324 FRLGTLVATIANLAMPDKIMIAG 346
Cdd:cd24060   240 TALGLGIVNILHTLNPSLVILSG 262
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 163-347 1.85e-11

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 64.64  E-value: 1.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 163 AVGISLGGHI--VDGTVVTFaPFMHWSQpVELSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGY 240
Cdd:cd24074    65 AIAITLPGIIdpESGIVHRL-PFYDIKN-LPLGEALEQHTGLPVYVQHDISAWTLAERFFGAAKGAKNIIQIVIDDDIGA 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 241 SLTFNGELVSCPDKSYGLVGHILVDPDGPRCVSGHRGCAQCL--------SDNSIAAEYSQIIGH--PASFDDFARDARA 310
Cdd:cd24074   143 GVITDGQLLHAGSSRLGELGHTQIDPYGKRCYCGNHGCLETVasipaileQANQLLEQSPDSMLHgqPISIESLCQAALA 222

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1672620298 311 NKPQATNLVNRTCFRLGTLVATIANLAMPDKIMIAGE 347
Cdd:cd24074   223 GDPLAQDIIIQVGRHLGRILAILVNLFNPEKILIGSP 259
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 105-336 2.87e-11

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 63.78  E-value: 2.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 105 INATHISAVAVNAIGQIITgchdlKIEDASPQ--TVVALIKQLTTDCSDEAEMAGwpkpcAVGISLGGHIVDGtVVT--- 179
Cdd:PRK05082    8 IGGTKIAAALVGEDGQIRQ-----RRQIPTPAsqTPEALRQALSALVSPLQAQAD-----RVAVASTGIINDG-ILTaln 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 180 ------FAPFmhwsqPVELSVmvREATGLPTGIYNDIDSLVVDACLFGPGVGLDsFAVLTFGAGVGYSLTFNGELVSCPD 253
Cdd:PRK05082   77 phnlggLLHF-----PLVQTL--EQLTDLPTIALNDAQAAAWAEYQALPDDIRN-MVFITVSTGVGGGIVLNGKLLTGPG 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 254 KSYGLVGHILVDPDGPRCVSGHRGCAQCL-SDNSIAAEYSQIIGHPASFDDFARdARANKPQATNLVNRTcfrlgtlVAT 332
Cdd:PRK05082  149 GLAGHIGHTLADPHGPVCGCGRRGCVEAIaSGRAIAAAAQGWLAGCDAKTIFER-AGQGDEQAQALINRS-------AQA 220


                  ....
gi 1672620298 333 IANL 336
Cdd:PRK05082  221 IARL 224
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 101-346 3.18e-11

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 63.90  E-value: 3.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 101 VGMKINATHISAVAVNAIGQIITGCHDLKIEDASPQTVVALIKQLTTDCSDEAEMAgwpKPCAVGISLGGHIVD--GTVV 178
Cdd:cd24063     3 VAVDIGGTWIRAGLVDEDGRILLKIRQPTPKTGDPGTVSEQVLGLIETLLSKAGKD---SIEGIGVSSAGPLDLrkGTIV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 179 tFAPFM--HWsqpVELSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVSCPDKSY 256
Cdd:cd24063    80 -NSPNIkgKE---IPLVEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYITISTGIGGGVIVDGRLLLGKNGNA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 257 GLVGHILVDPD-GPRCVSGHRGC-----------------AQCLSDNSIAAEYSQIIGHPASFDDFARdARANKPQATNL 318
Cdd:cd24063   156 AEVGHLVVDTEsGLKCGCGGYGHweafasgrgiprfarewAEGFSSRTSLKLRNPGGEGITAKEVFSA-ARKGDPLALKI 234

                         250       260
                  ....*....|....*....|....*...
gi 1672620298 319 VNRTCFRLGTLVATIANLAMPDKIMIAG 346
Cdd:cd24063   235 IEKLARYNGRGIANVINAYDPELIVIGG 262
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 163-346 1.03e-09

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 59.12  E-value: 1.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 163 AVGISLGGHI--VDGTVVTFAPFMHWSQpVELSVMVREATGLPTGIYNDIDSLVVdACL-FGPGVGLDSFAVLTFGAGVG 239
Cdd:cd24152    56 GIAISAPGVIdpETGIIYGGGALPYLKG-FNLKEELEERCNLPVSIENDAKCAAL-AELwLGSLKGIKNGAVIVLGTGIG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 240 YSLTFNGELVSCPDKSYGLVGHILVDPDGPRCVSGHRGCaqclSDNSIAAEYSQIIGHPASFD-DFARDARANKPQATNL 318
Cdd:cd24152   134 GAIIIDGKLYRGSHFFAGEFSYLLTDDDDKDLLFFSGLA----SMFGLVKRYNKAKGLEPLDGeEIFEKYAKGDEAAKKI 209

                         170       180
                  ....*....|....*....|....*...
gi 1672620298 319 VNRTCFRLGTLVATIANLAMPDKIMIAG 346
Cdd:cd24152   210 LDEYIRNLAKLIYNIQYILDPEVIVIGG 237
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 197-346 1.12e-09

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 59.14  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 197 REATGLPTGIYNDIDSLVVDACLFGPGVGLDS-FAVLtFGAGVGYSLTFNGELVSCPDKSYGLVGHILVDP------DGP 269
Cdd:cd24066    92 EARLGRPVRIENDANCFALSEATDGAGAGAGVvFGVI-LGTGVGGGIVVNGRVLTGANGIAGEWGHNPLPWpdedelPGP 170

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1672620298 270 RCVSGHRGCA-QCLSDNSIAAEYSQIIGHPASFDDFARDARANKPQATNLVNRTCFRLGTLVATIANLAMPDKIMIAG 346
Cdd:cd24066   171 PCYCGKRGCVeTFLSGPALERDYARLTGKTLSAEEIVALARAGDAAAVATLDRFLDRLGRALANVINILDPDVIVLGG 248
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 100-372 3.25e-09

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 57.68  E-value: 3.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 100 FVGMKINATHISAVAVNAIGQII----TGCHDLKIEDASPQTVVALIKQLTtdcsdeaEMAGWPKPCAVGISLGG----H 171
Cdd:cd24062     2 IVGIDVGGTTIKMAFLTQEGEIVqkweIPTNKLEGGENIITDIAESIQQLL-------EELGYSKEDLIGIGVGVpgpvD 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 172 IVDGTVVTfAPFMHWSQpVELSVMVREATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVSC 251
Cdd:cd24062    75 VETGTVEV-AVNLGWKN-FPLKDKLEALTGIPVVIDNDANAAALGEMWKGAGQGAKDLVFITLGTGVGGGVIANGKIVHG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 252 PDKSYGLVGHILVDPDGPR-CVSGHRGC---------------AQCLSDNSIAAEYSQIIGHPASFDDFARDARANKPQA 315
Cdd:cd24062   153 ANGAAGEIGHITVNPEGGApCNCGKTGCletvasatgivriarEELEEGKGSSALRILALGGELTAKDVFEAAKAGDELA 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1672620298 316 TNLVNRTCFRLGTLVATIANLAMPDKIMIAGESSFIAKFGIDDLRNGINMYRHSQAA 372
Cdd:cd24062   233 LAVVDTVARYLGLALANLANTLNPEKIVIGGGVSAAGEFLLSPVKEYFDRFTFPRVR 289
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 102-346 3.20e-07

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 51.46  E-value: 3.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 102 GMKINATHISAVAVNAIGQII------TGCHDLkieDASPQTVVALIKQLTTDCSDEAemagwpkpcAVGISLGG--HIV 173
Cdd:cd24057     4 GFDIGGTKIEFAVFDEALQLVwtkrvpTPTDDY---AAFLAAIAELVAEADARFGVKG---------PVGIGIPGviDPE 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 174 DGTVVTF-APFMHwSQPV--ELSvmvrEATGLPTGIYNDIDSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVS 250
Cdd:cd24057    72 DGTLITAnIPAAK-GRPLraDLS----ARLGRPVRIDNDANCFALSEAWDGAGRGYPSVFGLILGTGVGGGLVVNGRLVG 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 251 CPDKSYGLVGH-------ILVDPDGP--RCVSGHRGCAQC-LSDNSIAAEYSQIIGHPASFDDFARDARANKPQATNLVN 320
Cdd:cd24057   147 GRSGIAGEWGHgplpadaLLLGYDLPvlRCGCGQTGCLETyLSGRGLERLYAHLYGEELDAPEIIAAWAAGDPQAVAHVD 226

                         250       260
                  ....*....|....*....|....*.
gi 1672620298 321 RTCFRLGTLVATIANLAMPDKIMIAG 346
Cdd:cd24057   227 RWLDLLAGCLANILTALDPDVVVLGG 252
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 98-346 1.09e-05

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 46.77  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298  98 RSFVGMKINATHISAVAVNAIGQIitgCHDLKIEDASPQTVVALIKQLTTDCSDEAEMAGWpKPCAVGISLGGHI-VDGT 176
Cdd:cd24070     1 KYVLGIDIGGTNIRIGLVDEDGKL---LDFEKVPSKDLLRAGDPVEVLADLIREYIEEAGL-KPAAIVIGVPGTVdKDRR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 177 VVTFAPFMHWSQPVELSVMVREATGLPTGIYNDIDSL----VVDACLFGPGVGLDSFavltFGAGVGYSLTFNGELVSCP 252
Cdd:cd24070    77 TVISTPNIPGLDGVNLADILENKLGIPVILERDVNLLllydMRAGNLDDEGVVLGFY----IGTGIGNAILINGKPLRGK 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 253 DKSYGLVGHILVDPDGPRCVSGHRGCAQCLSDN----SIAAEYsqiigHPASFDDFARDARANKPQATNLVNrtcfRLGT 328
Cdd:cd24070   153 NGVAGELGHIPVYGNGKPCGCGNTGCLETYASGraleEIAEEH-----YPDTPILDIFVDHGDEPELDEFVE----DLAL 223

                         250
                  ....*....|....*...
gi 1672620298 329 LVATIANLAMPDKIMIAG 346
Cdd:cd24070   224 AIATEINILDPDAVILGG 241
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 185-346 3.26e-05

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 45.23  E-value: 3.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 185 HWSQpVELSVMVREATGLPTGIynDIDslvVDAC-----LFGPGVGLDSFAVLTFGAGVGYSLTFNGELVScpdksyGLV 259
Cdd:cd24067    81 GWRN-FDILGALKRAFPVPVGF--DTD---VNAAalaeyRWGAAKGLDSLAYITVGTGIGVGLVVNGKPVH------GLL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 260 ----GHILV-----DPDGPRCVSGHRGCAQCL-SDNSIAAEYsQIIGHPASFDDFARDARAnkpqatnlvnrtcFRLGTL 329
Cdd:cd24067   149 hpemGHIRVprhpdDDGFPGVCPFHGDCLEGLaSGPAIAARW-GIPAEELPDDHPAWDLEA-------------YYLAQA 214

                         170
                  ....*....|....*..
gi 1672620298 330 VATIANLAMPDKIMIAG 346
Cdd:cd24067   215 CANLTLTLSPERIVLGG 231
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 133-249 7.66e-05

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 43.71  E-value: 7.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 133 ASPQTVVALIKQLttdcsdeAEMAGWPKPcaVGISLGGHIVDGTVVTfAPFMH--WSQpVELSVMVREATGLPTGIYNDI 210
Cdd:cd24058    36 ATPEAVADVVAEL-------VAHFPWFGP--VGVGFPGVVRRGVVRT-AANLDksWIG-FDAAKLLSKRLGRPVRVLNDA 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1672620298 211 DSLVVDACLFGPGVGLDSFA-VLTFGAGVGYSLTFNGELV 249
Cdd:cd24058   105 DAAGLAEMKGGAGKGEKGVVlVLTLGTGIGSALFVDGHLV 144
PRK09698 PRK09698
D-allose kinase; Provisional
 100-377 7.67e-04

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 41.12  E-value: 7.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 100 FVGMKINATHISAVAVNAIGQIItGCHDLKIEDASPQTVVAlikQLTTDCSDEAEMAGWPkPCAVGISLGGhIV--DGTV 177
Cdd:PRK09698    6 VLGIDMGGTHIRFCLVDAEGEIL-HCEKKRTAEVIAPDLVS---GLGEMIDEYLRRFNAR-CHGIVMGFPA-LVskDRRT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 178 VTFAPFMHwSQPVE---LSVMVREATGLPTGIYNDIDSLVV-DACLFGpgvgLDSFAVLTF--GAGVGYSLTFNGELVSC 251
Cdd:PRK09698   80 VISTPNLP-LTALDlydLADKLENTLNCPVFFSRDVNLQLLwDVKENN----LTQQLVLGAylGTGMGFAVWMNGAPWTG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 252 PDKSYGLVGHILVDPDGPRCVSGHRGCAQCL-SDNSIAAEYSQiigHP--ASFDDFARDArANKPQATNLVNrtcfRLGT 328
Cdd:PRK09698  155 AHGVAGELGHIPLGDMTQHCGCGNPGCLETNcSGMALRRWYEQ---QPrdYPLSDLFVHA-GDHPFIQSLLE----NLAR 226

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1672620298 329 LVATIANLAMPDKIMIAGESSFIAKFGIDDLRNGInmYRHSQaAPVDFE 377
Cdd:PRK09698  227 AIATSINLFDPDAIILGGGVMDMPAFPRETLIAMI--QKYLR-KPLPYE 272
PRK13311 PRK13311
N-acetyl-D-glucosamine kinase; Provisional
 134-321 1.47e-03

N-acetyl-D-glucosamine kinase; Provisional


Pssm-ID: 106271 [Multi-domain]  Cd Length: 256  Bit Score: 40.01  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 134 SPQTVVALIKQLTTDCSDEAEM-AGWPKPCAVGISLGGHIVDGTVVTFAPFMHWSQPVE--LSVMVREATGlptgIYNDI 210
Cdd:PRK13311   31 TPREDYPQLLQILRDLTEEADTyCGVQGSVGIGIPGLPNADDGTVFTANVPSAMGQPLQadLSRLIQREVR----IDNDA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672620298 211 DSLVVDACLFGPGVGLDSFAVLTFGAGVGYSLTFNGELVSCPDKSYGLVGHI--------LVDPDGPR--CVSGHRGCAQ 280
Cdd:PRK13311  107 NCFALSEAWDPEFRTYPTVLGLILGTGVGGGLIVNGSIVSGRNHITGEFGHFrlpvdaldILGADIPRvpCGCGHRGCIE 186

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1672620298 281 -CLSDNSIAAEYSQIIGHPASFDDFARDARANKPQATNLVNR 321
Cdd:PRK13311  187 nYISGRGFEWMYSHFYQHTLPATDIIAHYAAGEPKAVAHVER 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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