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Conserved domains on  [gi|167041914|gb|ABZ06653|]
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putative NAD-dependent glycerol-3-phosphate dehydrogenase [uncultured marine microorganism HF4000_133I24]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GpsA super family cl33811
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 2-310 4.16e-59

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


The actual alignment was detected with superfamily member COG0240:

Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 193.33  E-value: 4.16e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914   2 KKILVIGAGAMGSAFTVPCVDNKNNVVLVGTHLEnkAIEQI-ASNDNLHPVLKCKLPKNLKIIkfDNFAEEFREKpDLIV 80
Cdd:COG0240    1 MKIAVLGAGSWGTALAKVLARNGHEVTLWGRDPE--VAEEInETRENPRYLPGVKLPENLRAT--SDLEEALAGA-DLVL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914  81 IGVSSKGIDWVGKEISKYYSKGTPILLLTKGlaILNNQFETLSEKLNQIFKKNgfkeINISVAKGPCLAAGLANKMRTSI 160
Cdd:COG0240   76 LAVPSQALREVLEQLAPLLPPGAPVVSATKG--IEPGTGLLMSEVIAEELPGA----LRIAVLSGPSFAEEVARGLPTAV 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914 161 VVANKNISVAKSIGKIISTDYYSTEFSDDVLGIEVCAALKNIYAMIIGASEGLsstsanaevkskhYF--NTAASLMHQS 238
Cdd:COG0240  150 VVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGL-------------GLgdNARAALITRG 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914 239 ISEMAHFTELLKGKKETVYGLAGLGDLYVSVIG--GRNSKMGKYLGNGVEYKKVKSEfMpNDTVEGA-------ELALEI 309
Cdd:COG0240  217 LAEMTRLGVALGARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGKGKSLEEALAE-M-GMVAEGVytakavyELAEKL 294


                 .
gi 167041914 310 G 310
Cdd:COG0240  295 G 295
 
Name Accession Description Interval E-value
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 2-310 4.16e-59

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 193.33  E-value: 4.16e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914   2 KKILVIGAGAMGSAFTVPCVDNKNNVVLVGTHLEnkAIEQI-ASNDNLHPVLKCKLPKNLKIIkfDNFAEEFREKpDLIV 80
Cdd:COG0240    1 MKIAVLGAGSWGTALAKVLARNGHEVTLWGRDPE--VAEEInETRENPRYLPGVKLPENLRAT--SDLEEALAGA-DLVL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914  81 IGVSSKGIDWVGKEISKYYSKGTPILLLTKGlaILNNQFETLSEKLNQIFKKNgfkeINISVAKGPCLAAGLANKMRTSI 160
Cdd:COG0240   76 LAVPSQALREVLEQLAPLLPPGAPVVSATKG--IEPGTGLLMSEVIAEELPGA----LRIAVLSGPSFAEEVARGLPTAV 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914 161 VVANKNISVAKSIGKIISTDYYSTEFSDDVLGIEVCAALKNIYAMIIGASEGLsstsanaevkskhYF--NTAASLMHQS 238
Cdd:COG0240  150 VVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGL-------------GLgdNARAALITRG 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914 239 ISEMAHFTELLKGKKETVYGLAGLGDLYVSVIG--GRNSKMGKYLGNGVEYKKVKSEfMpNDTVEGA-------ELALEI 309
Cdd:COG0240  217 LAEMTRLGVALGARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGKGKSLEEALAE-M-GMVAEGVytakavyELAEKL 294


                 .
gi 167041914 310 G 310
Cdd:COG0240  295 G 295
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
1-309 1.76e-41

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 147.14  E-value: 1.76e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914   1 MKKILVIGAGAMGSAFTVPCVDNKNNVVLVGTHLEnkAIEQIASNDNLHPVLK-CKLPKNLKIIkfDNFAEEFREKpDLI 79
Cdd:PRK00094   1 MMKIAVLGAGSWGTALAIVLARNGHDVTLWARDPE--QAAEINADRENPRYLPgIKLPDNLRAT--TDLAEALADA-DLI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914  80 VIGVSSKGIDWVGKEISKYYSKGTPILLLTKGLAilNNQFETLSEKLNQIFKKNgfkeINISVAKGPCLAAGLANKMRTS 159
Cdd:PRK00094  76 LVAVPSQALREVLKQLKPLLPPDAPIVWATKGIE--PGTGKLLSEVLEEELPDL----APIAVLSGPSFAKEVARGLPTA 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914 160 IVVANKNISVAKSIGKIISTDYYSTEFSDDVLGIEVCAALKNIYAMIIGASEGLSstsanaevkskhyF--NTAASLMHQ 237
Cdd:PRK00094 150 VVIASTDEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLG-------------LgdNARAALITR 216

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 167041914 238 SISEMAHFTELLKGKKETVYGLAGLGDLYV--SVIGGRNSKMGKYLGNGVEYKKVKSEFmpNDTVEG---AELALEI 309
Cdd:PRK00094 217 GLAEITRLGVALGANPETFLGLAGLGDLVLtcTSPLSRNRRFGLALGQGKSLEEALAEI--GMVAEGvrtAKAVYEL 291
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 189-337 2.06e-27

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 104.78  E-value: 2.06e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914  189 DVLGIEVCAALKNIYAMIIGASEGLsstsanaevksKHYFNTAASLMHQSISEMAHFTELLKGKKETVYGLAGLGDLYVS 268
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGL-----------GLGDNAKAALITRGLAEMIRLGKALGAKPETFFGLAGLGDLIVT 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 167041914  269 VIGG--RNSKMGKYLGNGVEYKKVKSEFmpNDTVEGAELALEIgPKILKEFKKEnFPLLMGLLEsICNNKK 337
Cdd:pfam07479  70 CTSGlsRNRRFGEALGKGKSLEEAEKEL--GQVAEGVYTAKAV-YELAKKLGVE-MPIFEAVYR-ILYEGK 135
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 3-324 2.39e-21

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 93.18  E-value: 2.39e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914    3 KILVIGAGAMGSAFTVPCVDN----------KNNVVLVGTHLENKAIEQI--ASNDNLHPVLKCKLPKNLKiikFDNFAE 70
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENaralpelfeeSVRMWVFEEEIEGRNLTEIinTTHENVKYLPGIKLPANLV---AVPDLV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914   71 EFREKPDLIVIGVSSKGIDWVGKEISKYYSKGTPILLLTKGLAILNNQFETLS----EKLNqifkkngfkeINISVAKGP 146
Cdd:TIGR03376  78 EAAKGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSdiieEELG----------IPCGVLSGA 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914  147 CLAAGLANKMRTSIVVA----NKNISVAKSIGKIISTDYYSTEFSDDVLGIEVCAALKNIYAMIIGASEGLSSTSanaev 222
Cdd:TIGR03376 148 NLANEVAKEKFSETTVGyrdpADFDVDARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGD----- 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914  223 kskhyfNTAASLMHQSISEMAHFTELL--KGKKETVYGLAGLGDLYVSVIGGRNSKMGKYLG-NGVEYKKVKSEFMPNDT 299
Cdd:TIGR03376 223 ------NAKAAVMRRGLLEMIKFARMFfpTGEVTFTFESCGVADLITTCLGGRNFKVGRAFAkTGKSLEELEKELLNGQS 296

                         330       340
                  ....*....|....*....|....*
gi 167041914  300 VEGAELALEIGPKILKEFKKENFPL 324
Cdd:TIGR03376 297 LQGVATAKEVHELLKNKNKDDEFPL 321
 
Name Accession Description Interval E-value
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 2-310 4.16e-59

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 193.33  E-value: 4.16e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914   2 KKILVIGAGAMGSAFTVPCVDNKNNVVLVGTHLEnkAIEQI-ASNDNLHPVLKCKLPKNLKIIkfDNFAEEFREKpDLIV 80
Cdd:COG0240    1 MKIAVLGAGSWGTALAKVLARNGHEVTLWGRDPE--VAEEInETRENPRYLPGVKLPENLRAT--SDLEEALAGA-DLVL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914  81 IGVSSKGIDWVGKEISKYYSKGTPILLLTKGlaILNNQFETLSEKLNQIFKKNgfkeINISVAKGPCLAAGLANKMRTSI 160
Cdd:COG0240   76 LAVPSQALREVLEQLAPLLPPGAPVVSATKG--IEPGTGLLMSEVIAEELPGA----LRIAVLSGPSFAEEVARGLPTAV 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914 161 VVANKNISVAKSIGKIISTDYYSTEFSDDVLGIEVCAALKNIYAMIIGASEGLsstsanaevkskhYF--NTAASLMHQS 238
Cdd:COG0240  150 VVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGL-------------GLgdNARAALITRG 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914 239 ISEMAHFTELLKGKKETVYGLAGLGDLYVSVIG--GRNSKMGKYLGNGVEYKKVKSEfMpNDTVEGA-------ELALEI 309
Cdd:COG0240  217 LAEMTRLGVALGARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGKGKSLEEALAE-M-GMVAEGVytakavyELAEKL 294


                 .
gi 167041914 310 G 310
Cdd:COG0240  295 G 295
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
1-309 1.76e-41

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 147.14  E-value: 1.76e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914   1 MKKILVIGAGAMGSAFTVPCVDNKNNVVLVGTHLEnkAIEQIASNDNLHPVLK-CKLPKNLKIIkfDNFAEEFREKpDLI 79
Cdd:PRK00094   1 MMKIAVLGAGSWGTALAIVLARNGHDVTLWARDPE--QAAEINADRENPRYLPgIKLPDNLRAT--TDLAEALADA-DLI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914  80 VIGVSSKGIDWVGKEISKYYSKGTPILLLTKGLAilNNQFETLSEKLNQIFKKNgfkeINISVAKGPCLAAGLANKMRTS 159
Cdd:PRK00094  76 LVAVPSQALREVLKQLKPLLPPDAPIVWATKGIE--PGTGKLLSEVLEEELPDL----APIAVLSGPSFAKEVARGLPTA 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914 160 IVVANKNISVAKSIGKIISTDYYSTEFSDDVLGIEVCAALKNIYAMIIGASEGLSstsanaevkskhyF--NTAASLMHQ 237
Cdd:PRK00094 150 VVIASTDEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLG-------------LgdNARAALITR 216

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 167041914 238 SISEMAHFTELLKGKKETVYGLAGLGDLYV--SVIGGRNSKMGKYLGNGVEYKKVKSEFmpNDTVEG---AELALEI 309
Cdd:PRK00094 217 GLAEITRLGVALGANPETFLGLAGLGDLVLtcTSPLSRNRRFGLALGQGKSLEEALAEI--GMVAEGvrtAKAVYEL 291
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 189-337 2.06e-27

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 104.78  E-value: 2.06e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914  189 DVLGIEVCAALKNIYAMIIGASEGLsstsanaevksKHYFNTAASLMHQSISEMAHFTELLKGKKETVYGLAGLGDLYVS 268
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGL-----------GLGDNAKAALITRGLAEMIRLGKALGAKPETFFGLAGLGDLIVT 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 167041914  269 VIGG--RNSKMGKYLGNGVEYKKVKSEFmpNDTVEGAELALEIgPKILKEFKKEnFPLLMGLLEsICNNKK 337
Cdd:pfam07479  70 CTSGlsRNRRFGEALGKGKSLEEAEKEL--GQVAEGVYTAKAV-YELAKKLGVE-MPIFEAVYR-ILYEGK 135
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 3-285 1.15e-23

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 99.47  E-value: 1.15e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914   3 KILVIGAGAMGSafTVPCVDNKNNVVLVGTHLENKAiEQIASNDNLHPVL--KCKLPKNLKIIKfdNFAEEFREKpDLIV 80
Cdd:PRK12439   9 KVVVLGGGSWGT--TVASICARRGPTLQWVRSAETA-DDINDNHRNSRYLgnDVVLSDTLRATT--DFAEAANCA-DVVV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914  81 IGVSSKGIDWVGKEISKYYSKGTPILLLTKGLAILNNQfeTLSEKLNQIFKKNgfkeiNISVAKGPCLAAGLANKMRTSI 160
Cdd:PRK12439  83 MGVPSHGFRGVLTELAKELRPWVPVVSLVKGLEQGTNM--RMSQIIEEVLPGH-----PAGILAGPNIAREVAEGYAAAA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914 161 VVANKNISVAKSIGKIISTDYYSTEFSDDVLGIEVCAALKNIYAMIIGASEGLSSTSanaevkskhyfNTAASLMHQSIS 240
Cdd:PRK12439 156 VLAMPDQHLATRLSPLFRTRRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGE-----------NTRAMVIARALR 224

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 167041914 241 EMAHFTELLKGKKETVYGLAGLGDLYVSVIG--GRNSKMGKYLGNGV 285
Cdd:PRK12439 225 EMTKLGVAMGGNPETFAGLAGMGDLIVTCTSqrSRNRHVGEQLGAGK 271
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 3-324 2.39e-21

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 93.18  E-value: 2.39e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914    3 KILVIGAGAMGSAFTVPCVDN----------KNNVVLVGTHLENKAIEQI--ASNDNLHPVLKCKLPKNLKiikFDNFAE 70
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENaralpelfeeSVRMWVFEEEIEGRNLTEIinTTHENVKYLPGIKLPANLV---AVPDLV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914   71 EFREKPDLIVIGVSSKGIDWVGKEISKYYSKGTPILLLTKGLAILNNQFETLS----EKLNqifkkngfkeINISVAKGP 146
Cdd:TIGR03376  78 EAAKGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSdiieEELG----------IPCGVLSGA 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914  147 CLAAGLANKMRTSIVVA----NKNISVAKSIGKIISTDYYSTEFSDDVLGIEVCAALKNIYAMIIGASEGLSSTSanaev 222
Cdd:TIGR03376 148 NLANEVAKEKFSETTVGyrdpADFDVDARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGD----- 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914  223 kskhyfNTAASLMHQSISEMAHFTELL--KGKKETVYGLAGLGDLYVSVIGGRNSKMGKYLG-NGVEYKKVKSEFMPNDT 299
Cdd:TIGR03376 223 ------NAKAAVMRRGLLEMIKFARMFfpTGEVTFTFESCGVADLITTCLGGRNFKVGRAFAkTGKSLEELEKELLNGQS 296

                         330       340
                  ....*....|....*....|....*
gi 167041914  300 VEGAELALEIGPKILKEFKKENFPL 324
Cdd:TIGR03376 297 LQGVATAKEVHELLKNKNKDDEFPL 321
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 3-293 2.92e-20

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 89.89  E-value: 2.92e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914   3 KILVIGAGAMGSAFTVPCVDNKNNVVLVGthlENKAI-EQIASN-DNLHPVLKCKLPKNlkIIKFDNFAEEFREKPDLIV 80
Cdd:PRK14620   2 KISILGAGSFGTAIAIALSSKKISVNLWG---RNHTTfESINTKrKNLKYLPTCHLPDN--ISVKSAIDEVLSDNATCII 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914  81 IGVSSKGIDWVGKEISK-YYSKGTPILLLTKGLAILNNQFEtlSEKLNQIFKKNgfkeiNISVAKGPCLAAGLANKMRTS 159
Cdd:PRK14620  77 LAVPTQQLRTICQQLQDcHLKKNTPILICSKGIEKSSLKFP--SEIVNEILPNN-----PIAILSGPSFAKEIAEKLPCS 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914 160 IVVANKNISVAKSIGKIISTDYYSTEFSDDVLGIEVCAALKNIYAMIIGASEGlsstsanaevkSKHYFNTAASLMHQSI 239
Cdd:PRK14620 150 IVLAGQNETLGSSLISKLSNENLKIIYSQDIIGVQIGAALKNIIAIACGIVLG-----------KNLGNNAHAAVITKGM 218

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 167041914 240 SEMahfTELLKGKKE-----TVYGLAGLGDLYV--SVIGGRNSKMGKYLGNGVEYKKVKSE 293
Cdd:PRK14620 219 NEI---KTLYSAKNGsidlnTLIGPSCLGDLILtcTTLHSRNMSFGFKIGNGFNINQILSE 276
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 2-265 1.14e-16

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 79.26  E-value: 1.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914   2 KKILVIGAGAMGSAFTVPCVDNKNNVVLVGTHLENKAIEQIASNDnlhpvlkcklpknlkiikfdnfaeefrekpdLIVI 81
Cdd:PRK14619   5 KTIAILGAGAWGSTLAGLASANGHRVRVWSRRSGLSLAAVLADAD-------------------------------VIVS 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914  82 GVSSKGIDWVGKEISKY-YSKGTPILLLTKGLAILnnQFETLSeklnQIFKKNgFKEINISVAKGPCLAAGLANKMRTSI 160
Cdd:PRK14619  54 AVSMKGVRPVAEQVQALnLPPETIIVTATKGLDPE--TTRTPS----QIWQAA-FPNHPVVVLSGPNLSKEIQQGLPAAT 126

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914 161 VVANKNISVAKSIGKIISTDYYSTEFSDDVLGIEVCAALKNIYAMIIGASEGLsSTSANAEvkskhyfntaASLMHQSIS 240
Cdd:PRK14619 127 VVASRDLAAAETVQQIFSSERFRVYTNSDPLGTELGGTLKNVIAIAAGVCDGL-QLGTNAK----------AALVTRALP 195

                        250       260
                 ....*....|....*....|....*
gi 167041914 241 EMAHFTELLKGKKETVYGLAGLGDL 265
Cdd:PRK14619 196 EMIRVGTHLGAQTETFYGLSGLGDL 220
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 4-286 6.96e-16

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 77.22  E-value: 6.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914   4 ILVIGAGAMGSAFTVPCVDNKNNVVLVGTHLEN-KAIEQIASNDNLHP-VLkckLPKNLKIIKfDnfAEEFREKPDLIVI 81
Cdd:PRK14618   7 VAVLGAGAWGTALAVLAASKGVPVRLWARRPEFaAALAAERENREYLPgVA---LPAELYPTA-D--PEEALAGADFAVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914  82 GVSSKGIdwvgKEISKYYSKGTPILLLTKGLAILNNQFETLSEKLnqifkknGFKEIN-ISVAKGPCLAAGLANKMRTSI 160
Cdd:PRK14618  81 AVPSKAL----RETLAGLPRALGYVSCAKGLAPDGGRLSELARVL-------EFLTQArVAVLSGPNHAEEIARFLPAAT 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914 161 VVANKNISVAKSIGKIISTDYYSTEFSDDVLGIEVCAALKNIYAMIIGASEGLSSTSanaevkskhyfNTAASLMHQSIS 240
Cdd:PRK14618 150 VVASPEPGLARRVQAAFSGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLKLGD-----------NAKAALITRGLR 218

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 167041914 241 EMAHFTELLKGKKETVYGLAGLGDLYVSVIG--GRNSKMGKYLGNGVE 286
Cdd:PRK14618 219 EMVRFGVALGAEEATFYGLSGLGDLIATATSphSRNRAAGEAIVRGVD 266
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 2-324 8.92e-13

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 68.51  E-value: 8.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914   2 KKILVIGAGAMGSAFTVPCVDNKNNVVLVGTHLENKAIEQIASNDNLHPVLK-----------CKLPKNlkIIKFDNFAE 70
Cdd:PTZ00345  12 LKVSVIGSGNWGSAISKVVGENTQRNYIFHNEVRMWVLEEIVEGEKLSDIINtkhenvkylpgIKLPDN--IVAVSDLKE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914  71 EFREKpDLIVIGVSSKGIDWVGKEISKY--YSKGTPILLLTKGLAILNNQFETLSEKLNqifkkngfKEINI--SVAKGP 146
Cdd:PTZ00345  90 AVEDA-DLLIFVIPHQFLESVLSQIKENnnLKKHARAISLTKGIIVENGKPVLCSDVIE--------EELGIpcCALSGA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914 147 CLAAGLANKMRTSIVVANKNISVAKSIGKIISTDYYSTEFSDDVLGIEVCAALKNIYAMIIGASEGLSSTSanaevkskh 226
Cdd:PTZ00345 161 NVANDVAREEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGT--------- 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914 227 yfNTAASLMHQSISEMAHFTELL--KGKKETVYGLAGLGDLYVSVIGGRNSKMGK--YLGNGVE-YKKVKSEFMPNDTVE 301
Cdd:PTZ00345 232 --NTKSAIIRIGLEEMKLFGKIFfpNVMDETFFESCGLADLITTCLGGRNVRCAAefAKRNGKKsWEEIEAELLNGQKLQ 309

                        330       340
                 ....*....|....*....|...
gi 167041914 302 GAELALEIGPKILKEFKKENFPL 324
Cdd:PTZ00345 310 GTVTLKEVYEVLESHDLKKEFPL 332
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 3-170 2.38e-12

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 64.14  E-value: 2.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914    3 KILVIGAGAMGSAFTVPCVDNKNNVVLVGThlENKAIEQIasNDNLHPV--LK-CKLPKNLKIIkfDNFAEEFREKpDLI 79
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADNGHEVRLWGR--DEELIEEI--NTTHENVryLPgIKLPENLKAT--TDLAEALKGA-DII 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914   80 VIGVSSKGIDWVGKEISKYYSKGTPILLLTKGLAILNNQFetLSEKLNQIFKKNgfkeINISVAKGPCLAAGLANKMRTS 159
Cdd:pfam01210  74 VIVVPSQALREVLKQLKGLLKPDAILVSLSKGIEPGTLKL--LSEVIEEELGIQ----PPIAVLSGPSHAEEVAQGLPTA 147

                         170
                  ....*....|.
gi 167041914  160 IVVANKNISVA 170
Cdd:pfam01210 148 TVIASKDEEAA 158
ApbA pfam02558
Ketopantoate reductase PanE/ApbA; This is a family of 2-dehydropantoate 2-reductases also ...
 4-128 1.16e-04

Ketopantoate reductase PanE/ApbA; This is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases, EC:1.1.1.169. The reaction catalyzed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH. AbpA catalyzes the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway. ApbA and PanE are allelic. ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway.


Pssm-ID: 426831 [Multi-domain]  Cd Length: 147  Bit Score: 41.83  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914    4 ILVIGAGAMGSAFTVPCVDNKNNVVLVgthLENKAIEQIASNDnlhpvLKCKLPKNLKIIKFDNF--AEEFREKPDLIVI 81
Cdd:pfam02558   1 IAILGAGAIGSLLGARLAKAGHDVTLI---LRGAELAAIKKNG-----LRLTSPGGERIVPPPAVtsASESLGPIDLVIV 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 167041914   82 GVSSKGIDWVGKEISKYYSKGTPILLLTKGLAILnnqfETLSEKLNQ 128
Cdd:pfam02558  73 TVKAYQTEEALEDIAPLLGPNTVVLLLQNGLGHE----EVLREAVPR 115
PanE COG1893
Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of ...
 3-108 3.43e-04

Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 441497 [Multi-domain]  Cd Length: 305  Bit Score: 41.77  E-value: 3.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167041914   3 KILVIGAGAMGSAFTVPCVDNKNNVVLV--GTHLEnkAIEQ----IASNDNLHPVLKcklpknlkiIKFDNFAEEFrEKP 76
Cdd:COG1893    2 KIAILGAGAIGGLLGARLARAGHDVTLVarGAHAE--ALREnglrLESPDGDRTTVP---------VPAVTDPEEL-GPA 69

                         90       100       110
                 ....*....|....*....|....*....|..
gi 167041914  77 DLIVIGVSSKGIDWVGKEISKYYSKGTPILLL 108
Cdd:COG1893   70 DLVLVAVKAYDLEAAAEALAPLLGPDTVVLSL 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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