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Conserved domains on  [gi|166795236|ref|NP_002344|]
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tumor-associated calcium signal transducer 2 precursor [Homo sapiens]

Protein Classification

Kazal-type serine protease inhibitor family protein( domain architecture ID 11082431)

Kazal-type serine protease inhibitor family protein may function as a serine protease inhibitor; similar to SPARC-related modular calcium-binding protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 101-145 5.67e-11

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


:

Pssm-ID: 459665  Cd Length: 66  Bit Score: 57.31  E-value: 5.67e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 166795236  101 DGLYDPDCDPEGRFKARQC-NQTSVCWCVNSVGVRR--TDKGDLSLRC 145
Cdd:pfam00086  19 SGLYIPNCDEDGFYKPVQChGSTGYCWCVDPEGQEIpgTRTRGGDPDC 66
 
Name Accession Description Interval E-value
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 101-145 5.67e-11

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 57.31  E-value: 5.67e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 166795236  101 DGLYDPDCDPEGRFKARQC-NQTSVCWCVNSVGVRR--TDKGDLSLRC 145
Cdd:pfam00086  19 SGLYIPNCDEDGFYKPVQChGSTGYCWCVDPEGQEIpgTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 72-145 1.02e-10

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 56.70  E-value: 1.02e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 166795236  72 KCLLLKARMSapknartlvrpSEHALVDNDGLYDPDCDPEGRFKARQCN-QTSVCWCVNSVGVR--RTDKGDLSLRC 145
Cdd:cd00191    1 PCERERASAL-----------ESLAGPKLSGLYVPQCDEDGNYEPVQCHgSTGYCWCVDPDGEEipGTRTRGGPPNC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 106-147 2.86e-07

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 46.60  E-value: 2.86e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 166795236   106 PDCDPEGRFKARQCNQTS-VCWCVNSVGVR--RTDKGDLSLRCDE 147
Cdd:smart00211   2 PQCDEDGNYEPVQCDGSSgQCWCVDATGREipGTRTEGGDPDCPS 46
 
Name Accession Description Interval E-value
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 101-145 5.67e-11

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 57.31  E-value: 5.67e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 166795236  101 DGLYDPDCDPEGRFKARQC-NQTSVCWCVNSVGVRR--TDKGDLSLRC 145
Cdd:pfam00086  19 SGLYIPNCDEDGFYKPVQChGSTGYCWCVDPEGQEIpgTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 72-145 1.02e-10

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 56.70  E-value: 1.02e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 166795236  72 KCLLLKARMSapknartlvrpSEHALVDNDGLYDPDCDPEGRFKARQCN-QTSVCWCVNSVGVR--RTDKGDLSLRC 145
Cdd:cd00191    1 PCERERASAL-----------ESLAGPKLSGLYVPQCDEDGNYEPVQCHgSTGYCWCVDPDGEEipGTRTRGGPPNC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 106-147 2.86e-07

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 46.60  E-value: 2.86e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 166795236   106 PDCDPEGRFKARQCNQTS-VCWCVNSVGVR--RTDKGDLSLRCDE 147
Cdd:smart00211   2 PQCDEDGNYEPVQCDGSSgQCWCVDATGREipGTRTEGGDPDCPS 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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